                         SEQUENCE LISTING

<110>  Sphingotec Theraupeutics GmbH
 
<120>  Neurokinin-1 Receptor Antagonists For Use In A Method Of 
       Prevention Of Cancer

<130>  S75030WO

<150>  EP13199852.8
<151>  2013-12-30

<160>  21    

<170>  PatentIn version 3.3

<210>  1
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Asp Ser Glu Glu Glu Met Lys Ala Leu Glu Ala Asp Phe Leu Thr 
1               5                   10                  15      


Asn Met His Thr Ser Lys Ile Ser Lys Ala His Val Pro Ser Trp Lys 
            20                  25                  30          


Met Thr Leu Leu Asn Val Cys Ser Leu Val Asn Asn Leu Asn Ser Pro 
        35                  40                  45              


Ala Glu Glu Thr Gly Glu Val His Glu Glu Glu Leu Val Ala Arg Arg 
    50                  55                  60                  


Lys Leu Pro Thr Ala Leu Asp Gly Phe Ser Leu Glu Ala Met Leu Thr 
65                  70                  75                  80  


Ile Tyr Gln Leu His Lys Ile Cys His Ser Arg Ala Phe Gln His Trp 
                85                  90                  95      


Glu Leu Ile Gln Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly 
            100                 105                 110         


Lys Glu Glu Val Ile Lys Arg Lys Ile Pro Tyr Ile Leu Lys Arg Gln 
        115                 120                 125             


Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu Lys Arg Asp Ser 
    130                 135                 140                 


Tyr Tyr Tyr 
145         


<210>  2
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Asp Ser Glu Glu Glu Met Lys Ala Leu Glu Ala Asp Phe Leu Thr 
1               5                   10                  15      


Asn Met His Thr Ser Lys Ile Ser Lys Ala His Val Pro Ser Trp Lys 
            20                  25                  30          


Met Thr Leu Leu Asn Val Cys Ser Leu Val Asn Asn Leu Asn Ser Pro 
        35                  40                  45              


Ala Glu Glu Thr Gly Glu Val His Glu Glu Glu Leu Val Ala Arg Arg 
    50                  55                  60                  


Lys Leu Pro Thr Ala Leu Asp Gly Phe Ser Leu Glu Ala Met Leu Thr 
65                  70                  75                  80  


Ile Tyr Gln Leu His Lys Ile Cys His Ser Arg Ala Phe Gln His Trp 
                85                  90                  95      


Glu Leu Ile Gln Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly 
            100                 105                 110         


Lys Glu Glu Val Ile Lys Arg Lys Ile Pro Tyr Ile Leu 
        115                 120                 125 


<210>  3
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Ile Pro Tyr Ile Leu 
1               5       


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210>  5
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Asp Ser Glu Glu Glu Met Lys Ala Leu Glu Ala Asp Phe Leu Thr 
1               5                   10                  15      


Asn Met His Thr Ser Lys Ile Ser Lys Ala His Val Pro Ser Trp Lys 
            20                  25                  30          


Met Thr Leu Leu Asn Val Cys Ser Leu Val Asn Asn Leu Asn Ser Pro 
        35                  40                  45              


Ala Glu Glu Thr Gly Glu Val His Glu Glu Glu Leu Val Ala Arg Arg 
    50                  55                  60                  


Lys Leu Pro Thr Ala Leu Asp Gly Phe Ser Leu Glu Ala Met Leu Thr 
65                  70                  75                  80  


Ile Tyr Gln Leu His Lys Ile Cys His Ser Arg Ala Phe Gln His Trp 
                85                  90                  95      


Glu Leu Ile Gln Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly 
            100                 105                 110         


Lys Glu Glu Val Ile 
        115         


<210>  6
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Asp Ser Glu Glu Glu Met Lys Ala Leu Glu Ala Asp Phe Leu Thr 
1               5                   10                  15      


Asn Met His Thr Ser Lys Ile Ser Lys Ala His Val Pro Ser Trp Lys 
            20                  25                  30          


Met Thr Leu Leu Asn Val Cys Ser Leu Val Asn Asn Leu Asn Ser Pro 
        35                  40                  45              


Ala Glu Glu Thr Gly Glu Val His Glu Glu Glu Leu Val Ala Arg Arg 
    50                  55                  60                  


Lys Leu Pro Thr Ala Leu Asp Gly Phe Ser Leu Glu Ala Met Leu Thr 
65                  70                  75                  80  


Ile Tyr Gln Leu His Lys Ile Cys His Ser Arg Ala Phe Gln His Trp 
                85                  90                  95      


Glu Leu Ile Gln Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly 
            100                 105                 110         


Lys Glu Glu Val Ile Lys Arg Lys Ile Pro Tyr Ile Leu Lys Arg Gln 
        115                 120                 125             


Leu Tyr Glu Asn 
    130         


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Ile Pro Tyr Ile Leu Lys Arg Gln Leu Tyr Glu Asn Lys Pro Arg 
1               5                   10                  15      


Arg Pro Tyr Ile Leu 
            20      


<210>  8
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Ile Pro Tyr Ile Leu Lys Arg Gln Leu Tyr Glu Asn Lys Pro Arg 
1               5                   10                  15      


Arg Pro Tyr Ile Leu Lys Arg Asp Ser Tyr Tyr Tyr 
            20                  25              


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu Lys Arg Asp 
1               5                   10                  15      


Ser Tyr Tyr Tyr 
            20  


<210>  10
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Cys Ser Gln Asp Cys Ala Thr Cys Ser Tyr Arg Leu Val Arg Pro 
1               5                   10                  15      


Ala Asp Ile Asn Phe Leu Ala Cys Val Met Glu Cys Glu Gly Lys Leu 
            20                  25                  30          


Pro Ser Leu Lys Ile Trp Glu Thr Cys Lys Glu Leu Leu Gln Leu Ser 
        35                  40                  45              


Lys Pro Glu Leu Pro Gln Asp Gly Thr Ser Thr Leu Arg Glu Asn Ser 
    50                  55                  60                  


Lys Pro Glu Glu Ser His Leu Leu Ala Lys Arg Tyr Gly Gly Phe Met 
65                  70                  75                  80  


Lys Arg Tyr Gly Gly Phe Met Lys Lys Met Asp Glu Leu Tyr Pro Met 
                85                  90                  95      


Glu Pro Glu Glu Glu Ala Asn Gly Ser Glu Ile Leu Ala Lys Arg Tyr 
            100                 105                 110         


Gly Gly Phe Met Lys Lys Asp Ala Glu Glu Asp Asp Ser Leu Ala Asn 
        115                 120                 125             


Ser Ser Asp Leu Leu Lys Glu Leu Leu Glu Thr Gly Asp Asn Arg Glu 
    130                 135                 140                 


Arg Ser His His Gln Asp Gly Ser Asp Asn Glu Glu Glu Val Ser Lys 
145                 150                 155                 160 


Arg Tyr Gly Gly Phe Met Arg Gly Leu Lys Arg Ser Pro Gln Leu Glu 
                165                 170                 175     


Asp Glu Ala Lys Glu Leu Gln Lys Arg Tyr Gly Gly Phe Met Arg Arg 
            180                 185                 190         


Val Gly Arg Pro Glu Trp Trp Met Asp Tyr Gln Lys Arg Tyr Gly Gly 
        195                 200                 205             


Phe Leu Lys Arg Phe Ala Glu Ala Leu Pro Ser Asp Glu Glu Gly Glu 
    210                 215                 220                 


Ser Tyr Ser Lys Glu Val Pro Glu Met Glu Lys Arg Tyr Gly Gly Phe 
225                 230                 235                 240 


Met Arg Phe 
            


<210>  11
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Cys Ser Gln Asp Cys Ala Thr Cys Ser Tyr Arg Leu Val Arg Pro 
1               5                   10                  15      


Ala Asp Ile Asn Phe Leu Ala Cys Val Met Glu Cys Glu Gly Lys Leu 
            20                  25                  30          


Pro Ser Leu Lys Ile Trp Glu Thr Cys Lys Glu Leu Leu Gln Leu Ser 
        35                  40                  45              


Lys Pro Glu Leu Pro Gln Asp Gly Thr Ser Thr Leu 
    50                  55                  60  


<210>  12
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Gly Gly Phe Met 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Gly Gly Phe Leu 
1               5   


<210>  14
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly Ser 
1               5                   10                  15      


Glu Ile Leu Ala 
            20  


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ala Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys 
1               5                   10                  15      


Glu Leu Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp 
            20                  25                  30          


Gly Ser Asp Asn Glu Glu Glu Val Ser 
        35                  40      


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Gly Gly Phe Met Arg Gly Leu 
1               5               


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln 
1               5                   10          


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Gly Arg Pro Glu Trp Trp Met Asp Tyr Gln 
1               5                   10      


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Ala Glu Ala Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys 
1               5                   10                  15      


Glu Val Pro Glu Met Glu 
            20          


<210>  20
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Ala Glu Ala Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys 
1               5                   10                  15      


Glu Val Pro Glu Met Glu Lys Arg Tyr Gly Gly Phe Met 
            20                  25                  


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Tyr Gly Gly Phe Met Arg Phe 
1               5           


