                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  THERAPEUTIC METHODS AND COMPOSITIONS

<130>  B1834

<160>  31    

<170>  PatentIn version 3.3

<210>  1
<211>  447
<212>  DNA
<213>  Artificial

<220>
<223>  cDNA encoding hGIBsPLA2

<400>  1
atgaaactcc ttgtgctagc tgtgctgctc acagtggccg ccgccgacag cggcatcagc     60

cctcgggccg tgtggcagtt ccgcaaaatg atcaagtgcg tgatcccggg gagtgacccc    120

ttcttggaat acaacaacta cggctgctac tgtggcttgg ggggctcagg cacccccgtg    180

gatgaactgg acaagtgctg ccagacacat gacaactgct acgaccaggc caagaagctg    240

gacagctgta aatttctgct ggacaacccg tacacccaca cctattcata ctcgtgctct    300

ggctcggcaa tcacctgtag cagcaaaaac aaagagtgtg aggccttcat ttgcaactgc    360

gaccgcaacg ctgccatctg cttttcaaaa gctccatata acaaggcaca caagaacctg    420

gacaccaaga agtattgtca gagttga                                        447


<210>  2
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  hGIBsPLA2

<400>  2

Met Lys Leu Leu Val Leu Ala Val Leu Leu Thr Val Ala Ala Ala Asp 
1               5                   10                  15      


Ser Gly Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Lys Met Ile Lys 
            20                  25                  30          


Cys Val Ile Pro Gly Ser Asp Pro Phe Leu Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Lys Cys Cys Gln Thr His Asp Asn Cys Tyr Asp Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Leu Asp Asn Pro Tyr Thr His Thr Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Ser Ala Ile Thr Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Ala His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys Gln Ser 
145             


<210>  3
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  3
atgaaactcc ttgtgctag                                                  19


<210>  4
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  4
acagcggcat cagc                                                       14


<210>  5
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  5
ttccgcaaaa tgatcaa                                                    17


<210>  6
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  6
cccggggagt gacccc                                                     16


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  7
tacggctgct actgtggctt                                                 20


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  8
gacacatgac aactgctacg acc                                             23


<210>  9
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  9
acccacacct attcatactc gt                                              22


<210>  10
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  10
atcacctgta gcagca                                                     16


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  11
agctccatat aacaaggca                                                  19


<210>  12
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Inhibitory nucleic acid molecule

<400>  12
caagaagtat tgtcagag                                                   18


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  13

Asn Asn Tyr Gly Cys Tyr 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  14

Cys Tyr Cys Gly Leu Gly 
1               5       


<210>  15
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  15

Tyr Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly Gly Ser Gly 
1               5                   10                  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  16

Phe Leu Glu Tyr Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly Gly Ser 
1               5                   10                  15      


Gly Thr Pro Val 
            20  


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  17

Gln Thr His Asp Asn 
1               5   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  18

Cys Gln Thr His Asp Asn Cys 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  19

Glu Cys Glu Ala Phe Ile Cys Asn Cys 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  20

Asp Arg Asn Ala Ala Ile 
1               5       


<210>  21
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Immunogenic peptide

<400>  21

Asp Arg Asn Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn Lys Ala 
1               5                   10                  15      


His Lys Asn Leu 
            20  


<210>  22
<211>  1487
<212>  PRT
<213>  Artificial

<220>
<223>  soluble receptor

<400>  22

Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu Thr His Ile 
            20                  25                  30          


Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln 
        35                  40                  45              


Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr 
    50                  55                  60                  


Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp Lys Trp Val 
65                  70                  75                  80  


Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys Leu Gly Leu 
                85                  90                  95      


Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu Cys Asp Ser 
            100                 105                 110         


Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met Ile Glu Gly 
        115                 120                 125             


Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr Val Val Ala 
    130                 135                 140                 


Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys Gly Asn Ala 
                165                 170                 175     


His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly His Trp His 
            180                 185                 190         


His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln Arg Asn Gly 
225                 230                 235                 240 


Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His Leu Ser Lys 
        275                 280                 285             


Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp Glu Lys Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys Gly Thr Leu 
                325                 330                 335     


Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln Gly Ile Leu 
        355                 360                 365             


Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp Pro Asp Trp 
    370                 375                 380                 


Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp Arg Lys Ser 
385                 390                 395                 400 


Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser Val Leu Met 
                405                 410                 415     


Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser Leu Leu Arg 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys Asp Cys Lys 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val Pro Ala Asp 
            500                 505                 510         


Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly Arg Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys Asp Ser Tyr 
                565                 570                 575     


Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp 
            580                 585                 590         


Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg Gly Gly Ser 
    610                 615                 620                 


Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr Glu Leu Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Ala Thr 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp Ala Trp Ser 
            740                 745                 750         


Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu 
        755                 760                 765             


Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu 
            820                 825                 830         


Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu 
        835                 840                 845             


Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu Glu Glu Gly 
865                 870                 875                 880 


Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro Val Ile Phe 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser Gln Arg Lys 
            900                 905                 910         


Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Thr Glu Asn 
        915                 920                 925             


Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val 
    930                 935                 940                 


Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys Pro Lys Gly 
945                 950                 955                 960 


Trp Leu Tyr Phe Asn Tyr Lys Cys Phe Leu Val Thr Ile Pro Lys Asp 
                965                 970                 975     


Pro Arg Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Val Ala 
            980                 985                 990         


Lys Gly Gly Thr Leu Val Ser Ile  Lys Ser Glu Leu Glu  Gln Ala Phe 
        995                 1000                 1005             


Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr Asn Val  Trp Ile Gly 
    1010                 1015                 1020             


Leu Gln  Ser Thr Asn His Glu  Lys Trp Val Asn Gly  Lys Pro Leu 
    1025                 1030                 1035             


Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile Ile Asn  Ile Pro Ser 
    1040                 1045                 1050             


Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile Pro Leu  Cys Ala Leu 
    1055                 1060                 1065             


Met Ser  Ser Asn Pro Asn Phe  His Phe Thr Gly Lys  Trp Tyr Phe 
    1070                 1075                 1080             


Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe Val Cys  Glu Lys Met 
    1085                 1090                 1095             


Gln Asp  Thr Leu Glu His His  Val Asn Val Ser Asp  Thr Ser Ala 
    1100                 1105                 1110             


Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg Thr Tyr  Lys Ile Ile 
    1115                 1120                 1125             


Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly Lys Ser  Cys Arg Met 
    1130                 1135                 1140             


His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp Ala Phe  His Gln Ala 
    1145                 1150                 1155             


Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly His Thr  His Trp Ile 
    1160                 1165                 1170             


Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr Phe Asp  Trp Ser Asp 
    1175                 1180                 1185             


Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys Asp Glu  Glu Ser Ala 
    1190                 1195                 1200             


Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr Asn Gly  Arg Trp His 
    1205                 1210                 1215             


Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly Ala Ile  Cys His Val 
    1220                 1225                 1230             


Val Thr  Glu Thr Lys Ala Phe  Glu His Pro Gly Leu  Cys Ser Glu 
    1235                 1240                 1245             


Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly Asn Cys  Tyr Ser Phe 
    1250                 1255                 1260             


Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu Asp Ala  His Glu Phe 
    1265                 1270                 1275             


Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala Ile Arg  Asp Ala Ala 
    1280                 1285                 1290             


Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu Ala Phe  Gly Ser Ser 
    1295                 1300                 1305             


Val Gln  Met Val Trp Leu Asn  Ala Gln Phe Asp Asn  Asn Asn Lys 
    1310                 1315                 1320             


Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr Glu Gln  Ser Asn Trp 
    1325                 1330                 1335             


Gly Leu  Arg Lys Pro Asp Met  Asp His Leu Lys Pro  His Pro Cys 
    1340                 1345                 1350             


Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp His Phe  Thr Pro Cys 
    1355                 1360                 1365             


Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met Glu Ala  Gly Ile Pro 
    1370                 1375                 1380             


Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu Ser His  Ser Ile Val 
    1385                 1390                 1395             


Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile Ala Leu  Gly Ile Phe 
    1400                 1405                 1410             


Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys Ser Asp  Ile Phe Gln 
    1415                 1420                 1425             


Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr Pro Thr  Leu Asn Phe 
    1430                 1435                 1440             


Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu Ile Ser  Asp Leu Glu 
    1445                 1450                 1455             


Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp Ala Pro  Ala Thr Glu 
    1460                 1465                 1470             


Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile Cys Ile  Ser Pro 
    1475                 1480                 1485         


<210>  23
<211>  1326
<212>  PRT
<213>  Artificial

<220>
<223>  soluble receptor

<400>  23

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Gly Ala 
1               5                   10                  15      


Ala Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Gly Arg Thr 
    50                  55                  60                  


Gly Ser Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp 
    370                 375                 380                 


Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr 
385                 390                 395                 400 


Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile 
                405                 410                 415     


Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp 
            500                 505                 510         


Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Glu Thr Cys Gly Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser 
                565                 570                 575     


Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr 
            580                 585                 590         


Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp 
        595                 600                 605             


Asn Thr His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly 
    610                 615                 620                 


Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys 
625                 630                 635                 640 


Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu 
                645                 650                 655     


Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser 
            660                 665                 670         


Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val 
        675                 680                 685             


Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe 
    690                 695                 700                 


Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val 
705                 710                 715                 720 


Asn Glu Leu Leu His Pro Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe 
                725                 730                 735     


Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu 
            740                 745                 750         


Trp Ser Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr 
        755                 760                 765             


Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Pro Asn Lys Thr 
    770                 775                 780                 


Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile 
785                 790                 795                 800 


Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val 
                805                 810                 815     


Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala 
            820                 825                 830         


Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp 
        835                 840                 845             


Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys 
    850                 855                 860                 


Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln 
865                 870                 875                 880 


Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val 
                885                 890                 895     


Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln 
            900                 905                 910         


Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser 
        915                 920                 925             


Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val 
    930                 935                 940                 


Trp Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys 
945                 950                 955                 960 


Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile 
                965                 970                 975     


Pro Lys Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe 
            980                 985                 990         


Cys Ala Glu Glu Gly Gly Thr Leu  Val Ala Ile Glu Ser  Glu Val Glu 
        995                 1000                 1005             


Gln Ala  Phe Ile Thr Met Asn  Leu Phe Gly Gln Thr  Thr Ser Val 
    1010                 1015                 1020             


Trp Ile  Gly Leu Gln Asn Asp  Asp Tyr Glu Thr Trp  Leu Asn Gly 
    1025                 1030                 1035             


Lys Pro  Val Val Tyr Ser Asn  Trp Ser Pro Phe Asp  Ile Ile Asn 
    1040                 1045                 1050             


Ile Pro  Ser His Asn Thr Thr  Glu Val Gln Lys His  Ile Pro Leu 
    1055                 1060                 1065             


Cys Ala  Leu Leu Ser Ser Asn  Pro Asn Phe His Phe  Thr Gly Lys 
    1070                 1075                 1080             


Trp Tyr  Phe Glu Asp Cys Gly  Lys Glu Gly Tyr Gly  Phe Val Cys 
    1085                 1090                 1095             


Glu Lys  Met Gln Asp Thr Ser  Gly His Gly Val Asn  Thr Ser Asp 
    1100                 1105                 1110             


Met Tyr  Pro Met Pro Asn Thr  Leu Glu Tyr Gly Asn  Arg Thr Tyr 
    1115                 1120                 1125             


Lys Ile  Ile Asn Ala Asn Met  Thr Trp Tyr Ala Ala  Ile Lys Thr 
    1130                 1135                 1140             


Cys Leu  Met His Lys Ala Gln  Leu Val Ser Ile Thr  Asp Gln Tyr 
    1145                 1150                 1155             


His Gln  Ser Phe Leu Thr Val  Val Leu Asn Arg Leu  Gly Tyr Ala 
    1160                 1165                 1170             


His Trp  Ile Gly Leu Phe Thr  Thr Asp Asn Gly Leu  Asn Phe Asp 
    1175                 1180                 1185             


Trp Ser  Asp Gly Thr Lys Ser  Ser Phe Thr Phe Trp  Lys Asp Glu 
    1190                 1195                 1200             


Glu Ser  Ser Leu Leu Gly Asp  Cys Val Phe Ala Asp  Ser Asn Gly 
    1205                 1210                 1215             


Arg Trp  His Ser Thr Ala Cys  Asp Ser Phe Leu Gln  Gly Ala Ile 
    1220                 1225                 1230             


Cys His  Val Pro Pro Glu Thr  Arg Gln Ser Glu His  Pro Glu Leu 
    1235                 1240                 1245             


Cys Ser  Glu Thr Ser Ile Pro  Trp Ile Lys Phe Lys  Ser Asn Cys 
    1250                 1255                 1260             


Tyr Lys  Phe Ser Thr Val Leu  Asp Ser Met Ser Phe  Glu Ala Ala 
    1265                 1270                 1275             


His Glu  Phe Cys Lys Lys Glu  Gly Ser Asn Leu Leu  Thr Ile Lys 
    1280                 1285                 1290             


Asp Glu  Ala Glu Asn Ala Phe  Leu Leu Glu Glu Leu  Phe Ala Phe 
    1295                 1300                 1305             


Gly Ser  Ser Val Gln Met Val  Trp Leu Asn Ala Gln  Phe Asp Gly 
    1310                 1315                 1320             


Asn Ser  Lys 
    1325     


<210>  24
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  24

Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser Leu Arg Trp Arg 
1               5                   10                  15      


Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr Ser Val Gln Val 
            20                  25                  30          


Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr Ile His Lys Trp 
        35                  40                  45              


<210>  25
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  25

Trp Glu Lys Asp Leu Asn Ser His Ile Cys Tyr Gln Phe Asn Leu Leu 
1               5                   10                  15      


Ser 
    


<210>  26
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  26

Asp Cys Glu Ser Thr Leu Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His 
1               5                   10                  15      


Ile Asp His Glu Ile Val Glu Lys 
            20                  


<210>  27
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  27

Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr Val Val Ala Arg Lys 
1               5                   10                  15      


Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser Gly Gly Asp Ile Cys 
            20                  25                  30          


Glu 
    


<210>  28
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  28

Leu Ser Tyr Leu Asn Trp Ser Gln Glu Ile Thr Pro Gly Pro Phe Val 
1               5                   10                  15      


Glu His His Cys Gly Thr Leu Glu Val Val Ser Ala 
            20                  25              


<210>  29
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  29

Ser Arg Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala 
1               5                   10                  15      


Glu Lys Asp Ser Tyr Phe Trp 
            20              


<210>  30
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  30

Trp Ile Cys Arg Ile Pro Arg Asp Val Arg Pro Lys Phe Pro Asp Trp 
1               5                   10                  15      


Tyr Gln Tyr Asp Ala Pro Trp Leu Phe Tyr Gln Asn Ala 
            20                  25                  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  inhibitor peptide

<400>  31

Ala Phe His Gln Ala Phe Leu Thr Val Leu Leu Ser Arg Leu Gly His 
1               5                   10                  15      


Thr His Trp Ile Gly Leu Ser Thr Thr Asp Asn Gly Gln Thr 
            20                  25                  30  


