                               SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
 
<120> SYSTEMIC DISCOVERY, MATURATION AND EXTENSION OF PEPTIDE BINDERS 
      TO PROTEINS

<130> P31913-WO

<140>
<141>

<150> 61/921,263
<151> 2013-12-27

<150> 61/921,259
<151> 2013-12-27

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Phe Glu Val Tyr Leu 
1               5   


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Trp Thr Val Tyr Ala 
1               5   


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Trp Glu Val His Leu 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Arg Ser Ile Leu Tyr 
1               5   


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Asn Gly Phe Glu Val Tyr Leu Pro Gly 
1               5                   


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ser Glu Trp Thr Val Tyr Ala Gly Asn 
1               5                   


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Thr Gly Trp Glu Val His Leu Gly Lys 
1               5                   


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Ser Cys Arg Ser Ile Leu Tyr Gly Gln 
1               5                   


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Thr Gly Phe Glu Val Tyr Ile Pro Gly Ala 
1               5                   10      


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Ala Ser Glu Trp Thr Val Tyr Ala Gly Asn Lys 
1               5                   10      


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Thr Gly Trp Glu Val His Leu Gly Lys Gly 
1               5                   10      


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gln Ser Cys Arg Ser Ile Leu Tyr Gly Asp Gly 
1               5                   10      


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
His Pro Gln 
1           


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Leu Ala Glu Tyr His 
1               5   


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Arg Pro Gly Trp Lys 
1               5   


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Pro Ala Trp Ala His 
1               5   


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Phe Asp Glu Trp Leu 
1               5   


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Trp Thr His Pro Gln Phe Glu 
1               5           


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Asp Tyr Leu Ala Glu Tyr His Gly Gly 
1               5                   


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Tyr Glu Arg Pro Gly Trp Lys Leu Ser 
1               5                   


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Pro Ala Pro Ala Trp Ala His Gly Gly 
1               5                   


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Asn Ser Phe Asp Glu Trp Leu Gln Lys 
1               5                   


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Trp Thr His Pro Gln Phe Glu Gln Lys 
1               5                   


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Ala Asp Tyr Leu Ala Glu Tyr His Gly Gly 
1               5                   10  


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Tyr Glu Arg Pro Gly Trp Lys Leu Gly Thr 
1               5                   10  


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Asp Pro Ala Pro Ala Trp Ala His Gly Gly 
1               5                   10  


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Asn Ser Phe Asp Asp Trp Leu Ala Lys Gly Gly 
1               5                   10      


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Gly Ala Val Asp Pro Ser Glu Leu Thr 
1               5                   


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Leu Ala Asp Lys Thr Gln Pro Phe Val Tyr 
1               5                   10  


<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
His Pro Gln Ala 
1               


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Tyr His Pro Gln 
1               


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gly Gly Trp Thr His Pro Gln Phe Glu Gly Gly 
1               5                   10      


<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Gly Asp Tyr Leu Ala Glu Tyr His Gly Gly 
1               5                   10      


<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Tyr Glu Arg Pro Gly Trp Lys Leu Ser Gly 
1               5                   10      


<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Pro Ala Pro Ala Trp Ala His Gly Gly 
1               5                   10      


<210> 36
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gly Asn Ser Phe Asp Glu Trp Leu Gln Lys Gly 
1               5                   10      


<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 37
Xaa Xaa Leu Ala Glu Tyr His Xaa Xaa 
1               5                   


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 38
Xaa Xaa Arg Pro Gly Trp Lys Xaa Xaa 
1               5                   


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 39
Xaa Xaa Pro Ala Trp Ala His Xaa Xaa 
1               5                   


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 40
Xaa Xaa Phe Asp Glu Trp Leu Xaa Xaa 
1               5                   


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Ile"

<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="Variant residue given in the sequence has no 
       preference with respect to that in the annotations for 
       variant position"

<400> 41
Arg Ser Lys Leu Tyr 
1               5   


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gly Asn Gly Phe Glu Val Tyr Leu Pro Gly Gly 
1               5                   10      


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gly Ser Glu Trp Thr Val Tyr Ala Gly Asn Gly 
1               5                   10      


<210> 44
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gly Ser Cys Arg Ser Ile Leu Tyr Gly Gln Gly 
1               5                   10      


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 45
Xaa Xaa Phe Glu Val Tyr Leu Xaa Xaa 
1               5                   


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 46
Xaa Xaa Trp Thr Val Tyr Ala Xaa Xaa 
1               5                   


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 47
Xaa Xaa Trp Glu Val His Leu Xaa Xaa 
1               5                   


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<400> 48
Xaa Xaa Arg Ser Ile Leu Tyr Xaa Xaa 
1               5                   


