                         SEQUENCE LISTING

<110>  SAHA, Saurabh
 
<120>  CANCER TREATMENTS USING COMBINATIONS OF CDK AND ERK INHIBITORS

<130>  C065272/0375605

<140>  US 61/919,597
<141>  2013-12-20

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  1
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggcct gccgcatgac tcgtggttcg       60

gaggcccacg tggccggggc ggggactcag gcgcctgggg cgccgactga ttacgtagcg      120

ggcggggccg gaagtgccgc tccttggtgg gggctgttca tggcggttcc ggggtctcca      180

acatttttcc cggctgtggt cctaaatctg tccaaagcag aggcagtgga gcttgaggtt      240

cttgctggtg tgaaatgact gagtacaaac tggtggtggt tggagcaggt ggtgttggga      300

aaagcgcact gacaatccag ctaatccaga accactttgt agatgaatat gatcccacca      360

tagaggattc ttacagaaaa caagtggtta tagatggtga aacctgtttg ttggacatac      420

tggatacagc tggacaagaa gagtacagtg ccatgagaga ccaatacatg aggacaggcg      480

aaggcttcct ctgtgtattt gccatcaata atagcaagtc atttgcggat attaacctct      540

acagggagca gattaagcga gtaaaagact cggatgatgt acctatggtg ctagtgggaa      600

acaagtgtga tttgccaaca aggacagttg atacaaaaca agcccacgaa ctggccaaga      660

gttacgggat tccattcatt gaaacctcag ccaagaccag acagggtgtt gaagatgctt      720

tttacacact ggtaagagaa atacgccagt accgaatgaa aaaactcaac agcagtgatg      780

atgggactca gggttgtatg ggattgccat gtgtggtgat gtaacaagat acttttaaag      840

ttttgtcaga aaagagccac tttcaagctg cactgacacc ctggtcctga cttccctgga      900

ggagaagtat tcctgttgct gtcttcagtc tcacagagaa gctcctgcta cttccccagc      960

tctcagtagt ttagtacaat aatctctatt tgagaagttc tcagaataac tacctcctca     1020

cttggctgtc tgaccagaga atgcacctct tgttactccc tgttattttt ctgccctggg     1080

ttcttccaca gcacaaacac acctctgcca ccccaggttt ttcatctgaa aagcagttca     1140

tgtctgaaac agagaaccaa accgcaaacg tgaaattcta ttgaaaacag tgtcttgagc     1200

tctaaagtag caactgctgg tgattttttt tttcttttta ctgttgaact tagaactatg     1260

ctaatttttg gagaaatgtc ataaattact gttttgccaa gaatatagtt attattgctg     1320

tttggtttgt ttataatgtt atcggctcta ttctctaaac tggcatctgc tctagattca     1380

taaatacaaa aatgaatact gaattttgag tctatcctag tcttcacaac tttgacgtaa     1440

ttaaatccaa ctttcacagt gaagtgcctt tttcctagaa gtggtttgta gacttccttt     1500

ataatatttc agtggaatag atgtctcaaa aatccttatg catgaaatga atgtctgaga     1560

tacgtctgtg acttatctac cattgaagga aagctatatc tatttgagag cagatgccat     1620

tttgtacatg tatgaaattg gttttccaga ggcctgtttt ggggctttcc caggagaaag     1680

atgaaactga aagcacatga ataatttcac ttaataattt ttacctaatc tccacttttt     1740

tcataggtta ctacctatac aatgtatgta atttgtttcc cctagcttac tgataaacct     1800

aatattcaat gaacttccat ttgtattcaa atttgtgtca taccagaaag ctctacattt     1860

gcagatgttc aaatattgta aaactttggt gcattgttat ttaatagctg tgatcagtga     1920

ttttcaaacc tcaaatatag tatattaaca aattacattt tcactgtata tcatggtatc     1980

ttaatgatgt atataattgc cttcaatccc cttctcaccc caccctctac agcttccccc     2040

acagcaatag gggcttgatt atttcagttg agtaaagcat ggtgctaatg gaccagggtc     2100

acagtttcaa aacttgaaca atccagttag catcacagag aaagaaattc ttctgcattt     2160

gctcattgca ccagtaactc cagctagtaa ttttgctagg tagctgcagt tagccctgca     2220

aggaaagaag aggtcagtta gcacaaaccc tttaccatga ctggaaaact cagtatcacg     2280

tatttaaaca tttttttttc ttttagccat gtagaaactc taaattaagc caatattctc     2340

atttgagaat gaggatgtct cagctgagaa acgttttaaa ttctctttat tcataatgtt     2400

ctttgaaggg tttaaaacaa gatgttgata aatctaagct gatgagtttg ctcaaaacag     2460

gaagttgaaa ttgttgagac aggaatggaa aatataatta attgatacct atgaggattt     2520

ggaggcttgg cattttaatt tgcagataat accctggtaa ttctcatgaa aaatagactt     2580

ggataacttt tgataaaaga ctaattccaa aatggccact ttgttcctgt ctttaatatc     2640

taaatactta ctgaggtcct ccatcttcta tattatgaat tttcatttat taagcaaatg     2700

tcatattacc ttgaaattca gaagagaaga aacatatact gtgtccagag tataatgaac     2760

ctgcagagtt gtgcttctta ctgctaattc tgggagcttt cacagtactg tcatcatttg     2820

taaatggaaa ttctgctttt ctgtttctgc tccttctgga gcagtgctac tctgtaattt     2880

tcctgaggct tatcacctca gtcatttctt ttttaaatgt ctgtgactgg cagtgattct     2940

ttttcttaaa aatctattaa atttgatgtc aaattaggga gaaagatagt tactcatctt     3000

gggctcttgt gccaatagcc cttgtatgta tgtacttaga gttttccaag tatgttctaa     3060

gcacagaagt ttctaaatgg ggccaaaatt cagacttgag tatgttcttt gaatacctta     3120

agaagttaca attagccggg catggtggcc cgtgcctgta gtcccagcta cttgagaggc     3180

tgaggcagga gaatcacttc aacccaggag gtggaggtta cagtgagcag agatcgtgcc     3240

actgcactcc agcctgggtg acaagagaga cttgtctcca aaaaaaaagt tacacctagg     3300

tgtgaatttt ggcacaaagg agtgacaaac ttatagttaa aagctgaata acttcagtgt     3360

ggtataaaac gtggttttta ggctatgttt gtgattgctg aaaagaattc tagtttacct     3420

caaaatcctt ctctttcccc aaattaagtg cctggccagc tgtcataaat tacatattcc     3480

ttttggtttt tttaaaggtt acatgttcaa gagtgaaaat aagatgttct gtctgaaggc     3540

taccatgccg gatctgtaaa tgaacctgtt aaatgctgta tttgctccaa cggcttacta     3600

tagaatgtta cttaatacaa tatcatactt attacaattt ttactatagg agtgtaatag     3660

gtaaaattaa tctctatttt agtgggccca tgtttagtct ttcaccatcc tttaaactgc     3720

tgtgaatttt tttgtcatga cttgaaagca aggatagaga aacactttag agatatgtgg     3780

ggttttttta ccattccaga gcttgtgagc ataatcatat ttgctttata tttatagtca     3840

tgaactccta agttggcagc tacaaccaag aaccaaaaaa tggtgcgttc tgcttcttgt     3900

aattcatctc tgctaataaa ttataagaag caaggaaaat tagggaaaat attttatttg     3960

gatggtttct ataaacaagg gactataatt cttgtacatt atttttcatc tttgctgttt     4020

ctttgagcag tctaatgtgc cacacaatta tctaaggtat ttgttttcta taagaattgt     4080

tttaaaagta ttcttgttac cagagtagtt gtattatatt tcaaaacgta agatgatttt     4140

taaaagcctg agtactgacc taagatggaa ttgtatgaac tctgctctgg agggagggga     4200

ggatgtccgt ggaagttgta agacttttat ttttttgtgc catcaaatat aggtaaaaat     4260

aattgtgcaa ttctgctgtt taaacaggaa ctattggcct ccttggccct aaatggaagg     4320

gccgatattt taagttgatt attttattgt aaattaatcc aacctagttc tttttaattt     4380

ggttgaatgt tttttcttgt taaatgatgt ttaaaaaata aaaactggaa gttcttggct     4440

tagtcataat tctt                                                       4454


<210>  2
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  3
<211>  1326
<212>  DNA
<213>  Rattus norvegicus

<400>  3
gccgttcatg gcggtttcgg ggtctccaac agcttctcag gttgaaatcc aaaagcctcc       60

cgaggcgggg tctgcggagt ttgagatttt tgcaggtgtg aaatgactga gtacaaactg      120

gtggtggttg gagcaggtgg cgttgggaaa agtgctttga caatccagct aatccagaac      180

cactttgtgg atgaatatga tcccaccata gaggattctt accgaaaaca agtggtgatt      240

gacggtgaga cctgtctact ggacatactg gacacagctg gacaagagga gtacagtgcc      300

atgagagacc aatacatgag gacaggcgaa gggttcctct gtgtgtttgc catcaataat      360

agcaaatcct ttgcagatat taacctctac agggagcaaa ttaagcgcgt gaaagactct      420

gatgatgtac ccatggtgct ggtagggaac aagtgtgact tgccaacaag gacagttgac      480

acaaagcaag cccacgagct ggccaagagt tatggaattc cattcattga aacctcagcc      540

aagacccgac agggtgtgga ggatgccttt tacacgcttg taagggagat acgccagtac      600

cggatgaaga agctcaacag cagtgaggat ggcactcaag gctgtatggg gctgccctgt      660

gtggtgatgt agtaagaccc tttaaaagtt ctgtcatcag aaacgagcca ctttcaagcc      720

tcactgatgc cctggttctg acatccctgg aggagacgtg tttctgctgc tctctgcatc      780

tcagagaagc tcctgcttcc tgcttcccca acttagttac tgagcacagc catctaacct      840

gagacctctt cagaataact acctcctcac tcggctgtcc gaccagagaa atgaacctgt      900

ttctccccag tagttctctg ccctgggttt cccctagaaa caaacacacc tgccagctgg      960

ctttgtcctc cgaaaagcag tttacattga tgcagagaac caaactatag acaagcaatt     1020

ctgttgtcaa cagtttctta agctctaagg taacaattgc tggtgatttc cccctttgcc     1080

cccaactgtt gaacttggcc ttgttagttt tgggggaaat gtcaaaaatt aatctcttcc     1140

cgagaataga attagtgttg ctgattgcct gatttgcaat gtgatcagct atattctata     1200

agctggcgtc tgctctgtat tcataaatgc aaacatgagt actgacgtaa gtgcatccct     1260

agtcttctca gctgcatgca attaaatcca acgttcacaa caaaaaaaaa aaaaaaaaaa     1320

aaaaaa                                                                1326


<210>  4
<211>  189
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  5
<211>  4470
<212>  DNA
<213>  Mus musculus

<400>  5
gggactgggg cgccttgggc gcctagtgat tacgtagcgg gtggggccgg aagtgccgct       60

ccctggcggg ggctgttcat ggcggtttcg gggtctccaa cagcttctca ggttgaagtc      120

caaaagcctc ccgaggcggg gtctgcggag tttgaggttt ttgctggtgt gaaatgactg      180

agtacaaact ggtggtggtt ggagcaggtg gtgttgggaa aagcgccttg acgatccagc      240

taatccagaa ccactttgtg gatgaatatg atcccaccat agaggattct taccgaaagc      300

aagtggtgat tgatggtgag acctgcctgc tggacatact ggacacagct ggacaagagg      360

agtacagtgc catgagagac cagtacatga ggacaggcga agggttcctc tgtgtatttg      420

ccatcaataa tagcaaatca tttgcagata ttaacctcta cagggagcaa attaagcgtg      480

tgaaagattc tgatgatgtc cccatggtgc tggtaggcaa caagtgtgac ttgccaacaa      540

ggacagttga cacaaagcaa gcccacgaac tggccaagag ttacggaatt ccattcattg      600

agacctcagc caagacccga cagggtgtgg aggatgcctt ttacacactg gtaagggaga      660

tacgccagta ccgaatgaaa aagctcaaca gcagtgacga tggcactcaa ggttgtatgg      720

ggctgccctg tgtgctgatg tagtaagaca ctttgaaagt tctgtcatca gaaaagagcc      780

actttgaagc tgcactgatg ccctggttct gacatccctg gaggagacct gttcctgctg      840

ctctctgcat ctcagagaag ctcctgcttc ctgcttcccc gactcagtta ctgagcacag      900

ccatctaacc tgagacctct tcagaataac tacctcctca ctcggctgtc tgaccagaga      960

aatagacctg tctctcccgg tcgttctctg ccctgggttc ccctagaaac agacacagcc     1020

tccagctggc tttgtcctct gaaaagcagt ttacattgat gcagagaacc aaactagaca     1080

tgccattctg ttgacaacag tttcttatac tctaaggtaa caactgctgg tgattttccc     1140

ctgcccccaa ctgttgaact tggccttgtt ggtttggggg gaaaatgtca taaattactt     1200

tcttcccaaa atataattag tgttgctgat tgatttgtaa tgtgatcagc tatattccat     1260

aaactggcat ctgctctgta ttcataaatg caaacacgaa tactctcaac tgcatgcaat     1320

taaatccaac attcacaaca aagtgccttt ttcctaaaag tgctctgtag gctccattac     1380

agtttgtaat tggaatagat gtgtcaagaa ccattgtata ggaaagtgac tctgagccat     1440

ctacctttga gggaaaggtg tatgtacctg atggcagatg ctttgtgtat gcacatgaag     1500

atagtttccc tgtctgggat tctcccagga gaaagatgga actgaaacaa ttacaagtaa     1560

tttcatttaa ttctagctaa tctttttttt tttttttttt ttttttggta gactatcacc     1620

tataaatatt tggaatatct tctagcttac tgataatcta ataattaatg agcttccatt     1680

ataatgaatt ggttcatacc aggaagccct ccatttatag tatagatact gtaaaaattg     1740

gcatgttgtt actttatagc tgtgattaat gattcctcag accttgctga gatatagtta     1800

ttagcagaca ggttatatct ttgctgcata gtttcttcat ggaatatata tctatctgta     1860

tgtggagaga acgtggccct cagttccctt ctcagcatcc ctcatctctc agcctagaga     1920

agttcgagca tcctagaggg gcttgaacag ttatctcggt taaaccatgg tgctaatgga     1980

ccgggtcatg gtttcaaaac ttgaacaagc cagttagcat cacagagaaa cagtccatcc     2040

atatttgctc cctgcctatt attcctgctt acagactttt gcctgatgcc tgctgttagt     2100

gctacaagga taaagcttgt gtggttctca ccaggactgg aagtacctgg tgagctctgg     2160

ggtaagccta gatatcttta cattttcaga cccttattct tagccacgtg gaaactgaag     2220

ccagagtcca tacctccatc tccttccccc cccaaaaaaa ttagattaat gttctttata     2280

tagctttttt aaagtattta aaacatgtct ataagttagg ctgccaacta acaaaagctg     2340

atgtgtttgt tcaaataaag aggtatcctt cgctactcga gagaagaatg taaaatgcca     2400

ttgattgttg tcacttggag gcttgatgtt tgccctgata attcattagt gggttttgtt     2460

tgtcacatga tacctaagat gtaactcagc tcagtaattc taatgaaaac ataaattgga     2520

taccttaatt gaaaaaagca aacctaattc caaaatggcc attttctctt ctgatcttgt     2580

aatacctaaa attctgaggt ccttgggatt cttttgttta taacaggatc ttgctgtgta     2640

gtcctagctg gcctcaaact cacaatactc ttcctggatc aatctcccaa gtgctgggat     2700

tacaggcaca ttccaccaca cacacctgac tgagctcgtt cctaatgagt tttcattaag     2760

caaattcccc atcaccttga aactaatcag aagggggaag aaacatttgc tatgctcctg     2820

agtgctaaca ctgggatcat tcacatgggg tttgcattcc taggcaaact aaactgctgc     2880

cttttacaac aaggctcagt catcttcctg aagctgctga gaccagcact tggtcttgtt     2940

ttgttttaat atgtctatat gactggtggt ggatccctaa atagtttatt aattaaactc     3000

cagttaagga gaaagttact caccttgacc cgtttgacca tatcccgtgt gtgtgtgtgt     3060

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcacgcgt atgtacgtac gtatgtatgt     3120

aggtatgtag gtggtttcca gtataaacac agaaacaaat ggagccaatt caggtttcag     3180

atgcccttac taacatatat tcccacgggg tgtgggtttt ggcacaacag tgacaaactt     3240

aaaagccaag taagagccgg gcgtggtggc gcacgccttt aatcccagca cttgggaggc     3300

agaggcaggc ggatttctga gttctaggcc atcctggtct acagtgagtt ccaggacagc     3360

cagtgctaca cagagaaacc ctgtctcgaa aagccaaaaa aaaaaaaaaa aaaaaaaaaa     3420

aaaagccaag taggtccagt tggtatagta tcaaagtgtt tttagagtaa ttagtgaagg     3480

tctgctttac ctcaaagttg cagagcctct cttcctgagt ttaagtgcct ggccggcagt     3540

cacaaattaa catgttgctg taaggcagtt agttgaagct ttgttcacac attggagagt     3600

atgaaaataa agtgttctaa gagcgctgat actggatctg tgtaaacctg gtaaatgccg     3660

tttgtccagg acttagcgtg tgtgagttgg tagctcagta cgagtttact agttccgcag     3720

tgtgtacaat ggaggcgggt ttgttttagc tggccacctg tagaatcagc ctttaaactg     3780

ctgtgaactt tgtcatgact tgaatatgaa gatagacaaa aactctgtaa agacaaatgt     3840

ttgttttccc ccttacagaa cgtgtgagct tggttttatc ttcctttgta tttagtcata     3900

acctctcaag ctggcagctc cgaccaagga tcagaagctg tgtgcgttcc acctggtgga     3960

attagctcag ctctatatga gaagtggagt taatggaaaa cgtgttgact gggtggtttc     4020

tatttaaaag agtgatgata attcttgaac agtagttttt attttgctat ttctttaagc     4080

tgactgatgt gccacaaaat tattttaagg tatttgtgtt ttaagagtgt tctcatgaga     4140

ttagttgtag atatttttta aaatacaact ggtttttaaa atctgagtat tgctctaagc     4200

aagtgtttag actcttacgg gaaggtgggt ggaagttgtt tggcttccgt atttccatgc     4260

gtgccgtcag acataggtca gaacgccaac tgtgcatcct gctgtttaaa gacctcttgg     4320

cctctgtgac cctcatgaag gggctgatat tttaagttga ctgtttgatt gtaaattaat     4380

cctttctaat ttttaaagac ttgcttgact gttttccttg ttaaataatt ttaaaaaaat     4440

aaaaaactgg aagttctttg cttaactgta                                      4470


<210>  6
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Leu Met 
            180                 185                 


<210>  7
<211>  570
<212>  DNA
<213>  Cavia porcellus

<400>  7
atgactgagt ataaactggt ggtggttgga gcaggtggtg tcgggaaaag tgcactgacc       60

atccagctaa ttcagaacca ctttgtcgat gaatatgatc ccaccataga ggattcttac      120

cgaaaacagg tggttataga tggtgaaact tgtctgttgg atattctgga tacagctgga      180

caagaggagt acagtgccat gagagaccaa tacatgagga caggcgaagg cttcctctgt      240

gtgtttgcca tcaataatag caaatcattt gcagatatta acctctacag ggagcagatt      300

aaacgagtaa aagactcaga tgatgtacct atggtgctgg tagggaacaa gtgtgatttg      360

ccaacaagga ctgttgacac aaaacaagcc catgaactgg ccaagagtta cgggattcca      420

ttcattgaaa cctcagccaa gaccagacag ggtgttgaag atgcatttta cacactcgta      480

agagaaatac gccagtacag aatgaaaaaa ctcaacagca atgatgatgg gactcaaggt      540

tgtatggggt tgccatgtgt ggtgatgtaa                                       570


<210>  8
<211>  189
<212>  PRT
<213>  Cavia porcellus

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Asn Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  9
<211>  1220
<212>  DNA
<213>  Cavia porcellus

<400>  9
gttccggggt cctcaacgtt tctcagggtt gagattctat atccttttga agctggggcg       60

gcagagcttg aggttcttgc tggtgtgaaa tgactgagta taaactggtg gtggttggag      120

caggtggtgt cgggaaaagt gcactgacca tccagctaat tcagaaccac tttgtcgatg      180

aatatgatcc caccatagag gattcttacc gaaaacaggt ggttatagat ggtgaaactt      240

gtctgttgga tattctggat acagctggac aagaggagta cagtgccatg agagaccaat      300

acatgaggac aggcgaaggc ttcctctgtg tgtttgccat caataatagc aaatcatttg      360

cagatattaa cctctacagg gagcagatta aacgagtaaa agactcagat gatgtaccta      420

tggtgctggt agggaacaag tgtgatttgc caacaaggac tgttgacaca aaacaagccc      480

atgaactggc caagagttac gggattccat tcattgaaac ctcagccaag accagacagg      540

gtgttgaaga tgcattttac acactcgtaa gagaaatacg ccagtacaga atgaaaaaac      600

tcaacagcaa tgatgatggg actcaaggtt gtatggggtt gccatgtgtg gtgatgtaac      660

aagatattta acaaagttct atcagaaaag agccactttc aagctgcact gataccctgg      720

tcctgacttc cctggaggag aagtatccct gttgctctct tcatctcaga gaagctcctg      780

ctgtttgtcc acctctcagt gtatgagcac agtctctgct tgagaacttc tcagaataac      840

tacctcctca cttggttgtc tgaccagaga aatgcacctc ttgttaattc cccaataatt      900

ttctgccctg ggctctcccc aacaaaaaac aaacacttct gccatccaaa aagcaacttg      960

gtctgaaaca gaaccaaact gtagattgaa attctcttaa aaagtcttga gctctaaagt     1020

tagcaaccgc tggtgatttt tattttcctt tttatttttg aacttggaac tgacctatgt     1080

tagattttgg agaaatgtca taaagtactg ttgtgccaag aagataatta tgttgctgaa     1140

tggttgattt atagtgttat cagctatatt ttacaaactg gcatctgctc tgtattcata     1200

aatacaaaaa tgaagccagg                                                 1220


<210>  10
<211>  189
<212>  PRT
<213>  Cavia porcellus

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Asn Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  11
<211>  1307
<212>  DNA
<213>  Canis lupus

<400>  11
tgattacgta gcgggcgggg ccggaagtgc cgctccctag tgggggctgt tcatggcggt       60

tccggggtct ccaacctttc tcctagttgt ggtcctaaat acgtcggaag cggaggcggc      120

gaagcttgag gttcttgctg gtgtgaaatg actgagtaca aactggtggt ggttggagca      180

ggtggtgttg ggaaaagcgc actgacaatc cagctaatcc agaaccactt tgtagatgaa      240

tatgatccca ccatagagga ttcttaccga aaacaggtgg ttatagacgg tgaaacctgt      300

ctgttggata tactggatac agctggtcaa gaagagtaca gtgccatgag agaccaatac      360

atgaggacag gcgaaggctt cctctgtgta tttgccatca ataatagcaa atcatttgca      420

gacattaacc tctacaggga acagattaag cgagtaaaag attcagatga tgtacctatg      480

gtgctagtag gaaacaagtg tgatttgcca acaaggacag ttgacacaaa acaagcccat      540

gaactggcca agagttatgg gattccattc attgaaacct cagccaagac cagacagggt      600

gtcgaggatg ccttttacac actggtaaga gaaatacgtc agtaccgaat gaagaaactc      660

aacagcagtg atgatgggac tcaaggttgt atggggttac catgtgtggt gatgtaacaa      720

gacactttta aagttctagc atcagaaaag agccactgtc aagctgcact gacaccctgg      780

tcctgacttc cctggaggag aagtattcct gttgctatct tcagtctcac aaagaagctc      840

ctgctacttc cccaactctc agtagatcag tacaatgttc tctatttgag aagttctccg      900

aacaactacc tcctcacttg gttgtctgac cagagaaatg aacctcttgt tccttcccgc      960

tgtttttcca ccctgaattc tcccccaaca cacataaaca aacctctgcc atcccaggtt     1020

tttcatctga aaaataattc atgctctgaa acagagaaca aaactgtaga catgaaattc     1080

tgtaggaaac aaggtcttga gctcaaaagt agcaactgct ggtgaccttt ttttcccccc     1140

tttttactgt tgaacttgga actatgttgg tttttggaga aatgtcataa gttactgttt     1200

tgctgagaat atagttaagt tgacatttgg tttgtttgta atatcattag ctattttcta     1260

taaattggca tctgctctgc attcataaat acacgagtga attctga                   1307


<210>  12
<211>  189
<212>  PRT
<213>  Canis lupus

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  13
<211>  3104
<212>  DNA
<213>  Felis catus

<400>  13
aaaaaataaa taaatttaag aaaccatttt aaaattatgc acagttgcag cctggaaaac       60

ttaaggtggc gccttatagt atcaatctta ggagctttat ttggtgcatt taacgcaact      120

ggtaattgca aaatccactt cgcctgtgta agtgaaaaat atagactgtt atcttgttgg      180

ccctatgaaa ttctgcactt ggtatttagc atatactcta ccttcattac tatctggcaa      240

gatgttctgc cttagcactc agttgcattc ttttcctttt ctttcctgtt cattatgctt      300

taattctgag gaccatatga gggtagaata tattaaaaat tacaaaaatt ataaaaattt      360

gtataggcaa accatttcct taagttgatg gccaaatgtt aaaatgttat ttttcatatc      420

atttataatc ttgtcacagt ccacttaacg aagtttggtt agatttcagt gaaaattatc      480

ttccagagta gttttttttt ttttttcctg ggattaggga ggggggtaac tttactgcaa      540

ttagtatgta tggtgcagaa tttcatgcaa atgaggtgtg ccagcagtgt ggtaatttaa      600

tcgtatttaa acaaaaacaa acaaaaaaaa aacgaatgca caaacttgct gctgcttaga      660

tcactgcagc ttctaggacc cagtttcttt tactgatttc aaaacaaaac aaaacaaaaa      720

aataaaaaaa gttgtgcctg aaatgaatct tgtttttttt ataagtagcc gcctggttcc      780

tgtgtcctgt gaaatacagg cacttgaccc ttggtgtagc ttctgttcga ctttatatca      840

cgggaatgga ttggtctgat ttcttggccc tcatcttgaa ttggccacat ccagggtccc      900

tggccagtgg actgaaggct ttgtctaaga ggacaagggc agctcagggg atgtggggga      960

gggcgctttt atcttccccg ttgtcgtttg aggttttgat cttctctggg taaagaggcc     1020

gtttatcttt gtaaacacaa aacatttttg ctttctccag ttttctgtta atggcgaaag     1080

aatggaagcg aataaagttt tactgatttt tgagactcta gcacctagcg ctttcatttt     1140

tgaaacgtcc tgtgtgggag gggcgggtct gggtgcggcc cgccgcgtga ctcctgagtc     1200

gggggcccac gtggctgggg cggggactcg gacgccccgg gcgccgactg attacgtagc     1260

gggcggggcc ggaagtgccg ctccctagtg ggggctgttc atggcggttc cggggtctcc     1320

atcctttttc ccagttgttc taaatcagtc ggaagcggag gcagcgaagt ttgaggttct     1380

cgctggtgtg aaatgactga gtacaaactg gtggtggttg gagcaggtgg tgttgggaaa     1440

agcgcactga caatccagct aatccagaac cactttgtag atgaatatga tcccaccata     1500

gaggattctt accgaaaaca ggtggttata gacggtgaaa cctgtctgtt ggacatactg     1560

gatacagctg gtcaagaaga gtacagtgcc atgagagacc aatacatgag gacaggcgaa     1620

ggcttcctct gtgtatttgc catcaacaat agcaaatcat ttgcagatat taacctttac     1680

agggaacaga ttaagcgagt aaaagactcc gatgatgtac ctatggtgct agtaggaaac     1740

aagtgtgatt tgccaacaag gaccgtcgac acaaaacaag cccacgaact ggccaagagt     1800

tatgggattc cattcattga aacctcagcc aagaccagac agggtgttga agatgccttt     1860

tacacactgg taagagaaat acgtcagtac cgaatgaaga aactcaacag cagtgatgac     1920

gggactcaag gttgtatggg gttaccgtgt gtggtgatgt aacaagatac ttttaaagtt     1980

ctagcatcag aaaagagcca ctgtcaagct gcactgacac cctggtcctg acttccctgg     2040

aggagaagcg ttcctgttgc tattttcagt ttcacaaaga agctcctgct atttccccaa     2100

ctctccgtag atcagtacat tattctctgt ttgagaagtt ctccgaataa ctacctcctc     2160

acttggttgt ctgaccagag aaatgaacct cttgttactc cccactgttt ttccaccctg     2220

gttctccccc agcacatata aacaaacctc ccaggttttt catctgaaaa gtaattcatg     2280

ctctgaaaca gagaaccaaa ctgtagacat gaaattctgt aggaaacaat gtcttgagct     2340

ctaaagtagc aactgctggt gacttttttt tttttttttt cctttttact gttgaacttg     2400

gaactatgtt ggtttttgga gaaatgtcgt aagttactgt tttgctgagt atatagttaa     2460

gtttaccatt cggtttgttt gtaatgtcat tggctatact ctgtacctgg catctgctct     2520

gcattcataa atacaaaagt gaattctgac ttttgagtct atcctagtgt tctcaacttc     2580

cacataatta aatctaactt ttgcagcaaa gtgccttttt cctagaagtg gtttgtagat     2640

ttgctttata atactttggt ggaatagatg tctcaaaaac cattatacat gaaaatgaat     2700

gtctgagata cgtctatgat ctgtctacct ttgagggaaa aatataccga cataatagca     2760

gatgccatgt cttacgtgta tgaagttgga tttccagaga cctgatttgg gtctcttcca     2820

agagaaagat gaaactggaa acaattatga ataacttcac ttaattttta cctaatctct     2880

acttcggggt gggagggcag ggagtaggtt accacttaca aaatatatgc aatttgtttc     2940

ttctagctta ctgataatga acttccattc ttatttaaat ttaggtcata tcctaaagct     3000

ttacatttgc aggtgttcga aattgtaagt ttaatgcagt tttatttaat agctatgatc     3060

aatgattttc aagcctcaga tgtattaacg gacacatttt cact                      3104


<210>  14
<211>  189
<212>  PRT
<213>  Felis catus

<400>  14

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  15
<211>  4283
<212>  DNA
<213>  Bos taurus

<400>  15
ggccgctccc tagtgggggc tgttcatggc ggttccgggg tctcccaaca attttcccgg       60

ttgtggtcgt aatctatccg aagtggaggc agtggagcta gaggttcttg ctggtgtgaa      120

atgactgagt acaaactggt ggtggttgga gcaggtggtg ttgggaaaag tgcactgaca      180

atccagctaa tccagaacca ctttgtagat gaatatgatc ccaccataga ggattcctac      240

cgaaaacagg tggttataga tggtgaaacc tgtctgttgg acatactgga tacagctgga      300

caagaggagt acagtgccat gagagaccaa tacatgagga caggcgaagg cttcctttgt      360

gtgtttgcca tcaataatag caaatcattt gcagatatta acctctacag ggaacagata      420

aagcgtgtaa aggactcgga tgatgtacct atggtgctag taggaaacaa gtgtgatttg      480

ccaacaagga cagttgacac aaaacaagcc catgaactgg ccaaaagtta tgggattcca      540

ttcattgaaa cctcagccaa gaccagacag ggtgttgaag atgcctttta cacactggta      600

agagaaatac gtcagtaccg aatgaaaaag ctcaacagca gtgatgatgg cactcaaggc      660

tgtatggggt tgccgtgtgt ggtgatgtaa caagatactt ttaaagttct cacatcagaa      720

aagagccact gtcaagctgc actgacaccc tggtcctgac ttccctggag gagaagtatt      780

cctgttgcta tcttcagttt caaaaagaag ctcctgctat ttccccaact ctcagtagat      840

caatataata ttctctattt gagaagttct caagaataac tacctcctca cttggttgtc      900

tgaccagaga attgaacctc ttgttactcc cagtattttt ccaccctggg ttctccccca      960

gcacacacaa acgcacctct gccacccagg tttttcatct gaaaagcaat taatactctg     1020

aaacagagaa ccaaactgta gaaacatgaa attctgtaga aaacaatgtc ttgagctcta     1080

aagtagcaac tgctggtgat tttttttttt tttttttcct ttttattgtt gaacttggaa     1140

ctatgttggt ttgtggagaa atgtcataaa ttactgtttt gctgagaata tagttaatgt     1200

tgctctctgg tttgtttgta atgttatcag ctatattcta taaactggca tctactctgt     1260

atttagaaat acaaaaatga atactgacct tttgagtcta ccctcatctt ctcgactttc     1320

ttgtaattaa atgtaacttt cacgatgaag tgccttttgc ctgggagtga ctcgtagact     1380

tcctttaaaa tacttcagtg gaatagatgt ctcagaaact gttatacata agaataaatg     1440

tctgagatat gtctatgacc catctagctt tgagggaaag atataccaat atgatagcag     1500

atgccatttc ttacatctat aacgttgatt ttctggagac ctattttggg gctctccgag     1560

agaaagatga gactataaat gattaggaat aatttcactt aatttttaca taacctccac     1620

tttttgtttt gtagtttact acctgcaaaa catataattt gattcctttt agcttacaga     1680

taatctaatg ttaaatgaac ttccattcat attttaattt ggatcatatc aggaagtcta     1740

catttgcagg tgttcaaaaa ttgtaaaagt gtgatgcagt tttatttaat agctgtgatc     1800

aatgattttc aagcctcaaa tatgttaata gacacatttt cactgtatat catggtatta     1860

ataattattg atgtatataa ttgtccttgg tccccttctc tgttcatcac ctcatggcaa     1920

tggcttgatt aattatttca gctgagtaaa gcatggtgct aatagaccag ggtcacagtg     1980

tcaaaacttc agtgagccag taagcatcac agagaaagaa attctttcac atttgctcac     2040

cattaactcc agctaatagt tttgccagat gtgtgtggtt agtcctgcaa ggaaaggaga     2100

agtcagttaa tacaaattct taaccaggac tggaaaaact tgttttcctg agaagggtca     2160

gcttagaagt ctttatctgg actctatttt tagccacatg gaaatcaaat taagctgatc     2220

ttttttctca agtttttgag agtgaggatg cctcagatca acatttttaa aatattcttt     2280

attcttacgt tcttttaagg gtttaaaaca acgttgagta attagtctgg gcataccagg     2340

taacaagctg ataagtttgt gctgaacaag aagtagcctt tggattgaaa ttgctgtttt     2400

gagaagggat agaaaatata attaataatt atgagacttg acttttctat ttgcagataa     2460

tatcctgata attctgatga aaatagactt ggataatttt tgataaaaga atcgttccaa     2520

aatggccact tgctgttctt gtcttctaat gtgtaaatac ttactgaggt cctcttctaa     2580

tatgagttgt catttattaa gcaaattcca cattgccttg aaatgaattc ggaagagaag     2640

aaaaagtcat agtataccca gagaatgaaa aatccagaga attgtgctcc ttagtgttaa     2700

ttctgaagcc ttcgtagtcc acacccatag acagaaactc tctgccactt tgcttctgct     2760

cctcttggag cattgcgctg tcatttcctt gaggatagat tgaggcttgt caactcagtt     2820

gtattgtctt cctcctcttc ctcttgtctg tgtgactgac agtgtgactc ttactaatgt     2880

cagatgcggg gatgcgggga ggtggggggg agtagctcat tttaggctct tgcacccttt     2940

accgttgtat gtgtgtgtct tttagttttc tcaagaatgt tctaagcaca gaagtatcta     3000

aatggggcca aaattcagac ttgaaaatgt tcttttaata gcttcttaaa aagttacact     3060

ttggtgtgaa ttttggcagg atagagtgac aaactcttaa acgctgaata acttcagtta     3120

gtgtgttata gtttttagaa tatgtttgtg attgctgaaa acaattatag tttacctcaa     3180

aatctgaaag tctctttccc caagttaagt gcctggccag ctgtcaaaga ttacatatta     3240

ctttatgttt gtttgttttt taaaggttgc acattcaaga ttgtgaaaat aaggtgttct     3300

gtctgaaagc taccatgcct gtctgtaaat gaatccactg agtgctgtac ttgttccaac     3360

agcttactac agaatgctac ttggtaatat catactcgtt acagttttca cttcaggagt     3420

gtactaggta gaatgatcct gtgtgtattg tagtgggctc catgtttagt cttttcagca     3480

tcctttaaac tgctgtgaat ttttgtcttg acttgaaagc aaggatagag aaacacttta     3540

aagagatact ttgggttttt ttccattcca gaattggtga gcatagttag attttgcttt     3600

acatttacag tcatgaactc ttaagctggc agctacaacc aagaaccaaa agagggtgca     3660

ttctgcttct tgtaattcat ctttgctaat aaattatgag aagcaaagat aattaattag     3720

agaaactatt ttatttgggt ggtttctata aacaagggac tataattctt aaacattatt     3780

tttcattttt gctgtttctt taagaaacct aatgtgccac aacattattt taaggtgttt     3840

cttaaaagaa ttgtttttaa aagtgttctc attttcagag taattgtaga tatatttcaa     3900

aatataactg ataattttta aaggcctgag tactgaccta agaagcagtt gtatgaattc     3960

tctgggggga agggaggagc tcagtgaaag ttgtatgact tttatatttc tgtgccatca     4020

aataaaggta aaaatgtctt ttgtgcagtt ttgctgttca aacagaaact attggcctcc     4080

ttggccctaa atgaaagggc tggtatttta agttgactat tttattgtaa attaatccat     4140

cttaattttt ttaaatttgg ttgaatgttc tcttgttaaa tgtttaaaaa ataaaaactg     4200

gaagttcttt gcttagtcat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4260

aaaaaaataa aaaaaaaaaa aaa                                             4283


<210>  16
<211>  189
<212>  PRT
<213>  Bos taurus

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  17
<211>  4825
<212>  DNA
<213>  Gallus gallus

<400>  17
gcgccgggac cggaagccgg aagctttgca gaagggtgtt ccgcgttcgc ggtgcgggag       60

cggtcagccg gggtggcggg gctggggccg gccggggcag gcggctccgc gctccgcact      120

gggccgctgg gagggcgatg actgaataca agctggtggt ggtgggagct ggcggcgtcg      180

ggaagagcgc gttgaccatc cagctcatcc agaaccactt cgtggacgag tacgacccca      240

ccatcgagga ttcgtacaga aagcaggttg tcatcgatgg agagacgtgc ttgttggaca      300

ttctggacac tgcaggacag gaagaataca gtgctatgcg tgatcagtac atgagaactg      360

gggaaggatt cctttgtgtg tttgccatta acaacagtaa atcattcgct gatattaacc      420

tttacagaga gcaaatcaag agagtgaaag attcagacga tgtgccaatg gtgctggtgg      480

ggaataagtg cgatttgcca acaaggacag tagacaccaa acaggctcaa gagttagcaa      540

aaagctacgg cattcccttc atagagacat cagccaaaac gagacagggt gtggaagatg      600

cgttttacac actggtgagg gagattcggc agtaccggat gaaaaagctc aacagcaacg      660

aagatgggaa tcagggctgt atggggttgt cctgcattgt gatgtgataa gatgccaggt      720

tcagatgtag ctgctggaca agtctcgatg ctactgtatt gtgtctcatg ctgatgccct      780

gcagtatttt ggtgccagcg accagactct tggtaccagt taattagctc aggatccttt      840

cctgtgctcc atctgaagaa aacatctctg gtatctacct ccttgctcag ctcacagagc      900

agtcatatct cttggtgtac tgggattctt ttctagctgt gttgtctggg tttgttcaag      960

aagaaaacca gtcacaagaa aagtgaatta cagagactaa atgctgtgaa aaagatcaca     1020

ctttacctcc agagtaaaag ctagaagtgg cgtttgaccc ctttgcattg gattcagatt     1080

tgcggtgttg tcagaggagt ggcagaagta attttgccat tacaaaggtt tctgtcacca     1140

gtcggattgg tatctgctgt ctgtgcaccc acacagtgta tctgcaacat ctgcattgtg     1200

ccagaagtat cacttaactg atgaactgat cctttatttt tctgtaataa aaaggagata     1260

tctttgctaa cttaagtgcc tgtttgctca gaaggttgga ggttgtatgc tgttcccttg     1320

ggctgaggag aaccccaagg atgaatttct tgggtgctca ttgtcttgag caggcaagtt     1380

ttgtgtgggt gatctctttt catggcagga tattaaaatg ggaatttgta gtctggaaga     1440

tggagcagct gtttgtgaga ctcttgagtt agggagagaa atgtatacca cgtctgttct     1500

cgatccatca gaatggatcc atccacctct ttgtgtgtgg aactgtgtat agtctgtatt     1560

ggttttctac agcacttgga tctctttgga ccaaattagc gagctgttca ttttaacata     1620

actgccagta tttatagaca atttcttacg gacagataat gaatttagaa actggaggtt     1680

actttgggca gctgttcctc agctctgtct gtaacttgca aattattctg agttattttc     1740

tgcagaacct ccttccttat cacgggagga gcctgggagt tgaggttgac tgtaattggg     1800

tcaatggttg tcacagactt aaggtgtcca ggctgattgg aggaggcact gagccctaac     1860

agagcactga gctgacttct aattgcagca tccttgcaaa atgaggaagg gagttcagtg     1920

atgtctgcac tgaagatgta tgatacactg atagcagttc tgggtatgtt gtaacagctt     1980

caaagtagaa ccgcagtact gcgtgagctg tgtgacttct tcctagaaca cagcactgtc     2040

accccatatg gttgggacgt gcaggtgaga ccaacaccta ccaggttccc tggcgtaccg     2100

tggccttctc agttcttgtg ccagtgatac tgggttctgt tctgtggtgt cagacagcgt     2160

cctgtagcaa agctgaattc ccacttagtc tggtgagaga ataaagagcc atcagccaac     2220

agagggagcg ttcattctgc tggagcagtg cgagctgtaa gcattacgag aggcgtagtt     2280

tcagtttgtt gcagtcaggt tcctatattt tcaaagctga aatcagaaat aagtaaatac     2340

ggagaaaata agctgttgct tttaatgctc tttcctccac taattgtact cttaattttc     2400

ttcttgggag gccgaggatc catctgcata actttagctg tgatgctcca gataagtgtt     2460

tagaattcat tttatctttg actgatggga ctgataagaa gttaacgcac aatattttta     2520

catacaacat cgttttccag tgacctcctg agcggtggga agcattatgg gatagcaccg     2580

gctgtgactc gagttcattt gaaggcgatc tcttgcctgc aggttaaatg ggacggagtc     2640

agaatcactg tgagccgtct gtaatcagca aacagtctgt gggcttttct tactgtgttc     2700

tctctgtttg ccttagtttg gtgcaggaag agttccttgt gacagcgtcc tttgaggtgt     2760

gttgcaggag ctgaccattt gctccttgag ctgtgtgatg aactgttgtc cacttaatgg     2820

agttacagaa gcagcttctg ggagtcgcat ctggtcgcat acattcagtg ttttgggaag     2880

ctgtcagtgt ggtgtttgca ctgtgtttga atggtgttca tggtgggtct gttatgctcc     2940

tggatgattt ggggagatgt ggggctgctt ccgtggcaga caggatcagc tcagggcgct     3000

gctgcctatg gctgtgggaa acctcacagt tggtgtttga atagtggcca agtatgtcaa     3060

ttaaaaatac attttgaagg gaggtttgtc atagctctgt actttggcat gctctgctta     3120

ctgaaaacat actagctgta gctcaaaaaa agttgtgaat cctcagaata atacaggagc     3180

tggcaattgt ggctgctttc tctttgtgtt ccttttctct tgggttggat gaagctttaa     3240

aaaggaagga gccctggtga gggttggtca gtgtgcattt cattcttgga accagagagg     3300

aagttgcatc aactttcagg acgctgcaga gctcacttgc acaggtggtg ctccagtcta     3360

tgtgattttt ggggtcaaat cttgagatga tcttacaaaa tcagattttg tacccatcat     3420

gagcatgagg tgagtggttg tgctcggttt ctagctgcat gtatgtatac agacacgtgt     3480

atgcagacat gtctatgtgt gagtagttcg agtcagtcaa ggttactggc agcacctaaa     3540

gcgtatgcac cacataatgc atgcaggcaa aagtcctatc ttaggagcca tctcttcatg     3600

ggtttgggtt tatataggca gtatttttaa acagaatatc cgaagcactt tctggagttc     3660

tgtggtaatg cagtgacacc tatttggatg aaggaagatg tgtctgagga gcacgtaagc     3720

agatttgctg ccctaacaga gaggttttgg taaccgtgga aaaggttttc tcctggatct     3780

gtgtgtgctc ttggtgagct gcaatccatg acagggcaca accagatgag aaggaaaccc     3840

ggccatccca tgcttgagca cagctctgac tcagtagttc caccagatgt gccctttcag     3900

tcaaagtgtt ctgatctctt agagctttct gtagttcaag ttaccactca ctctccagct     3960

tgctcggtta atgtctgttg gcggcgttga gttggacttg ggaaaggtgt gtgtggtagg     4020

aacaagcaga gtgtgatgtg cttctgttat caggacttaa gctagagtgg ttggcagata     4080

ggaaatgcag ctattccttg aaagcaagca gatcatggat ggtcagccaa actgccctgg     4140

ctttggtggg agctgcactg cagaaggacc aaaccccaac aagatttggc acatttgttt     4200

agaagataag cacagatggt tttgcacaag gcagctcctc ataatggtgg ctttgtagat     4260

ttagtccaaa tgttcttatt tagatctagc agcacatcac tgtgtccgtg cccatctaac     4320

ctcgctatcc taagtagagc agaccccaaa caaccttgtt caaaaactac cagtgcaaat     4380

aactgaacta aatatttgtt actgctgact gagaacagct gttcgagtgt agcattgtgg     4440

cttgttaatg tgagtgcccc aactctatgg tcttattaaa gaaacccaaa cattgctcag     4500

attttgttct tattgtcatc ataagacttg aatagtgatg gtaatgctta cgtagacgtg     4560

tcttgtgagt gcacttcagt gatttagaaa gaactggatt tcaagcaact ttggacctgt     4620

ggggggaggg agattaatga aggtttgaat cacattctaa ttctatgtac agtccttcat     4680

tactccacaa gcctaaatcc tatacagcct ccaggatagc tggaaactgt tgagatctgg     4740

actttttttt tttaatccaa gggctaactt gttgtaactt ggtataatta tctgctttcg     4800

gaaatgcatc tctgttggtt tgaaa                                           4825


<210>  18
<211>  189
<212>  PRT
<213>  Gallus gallus

<400>  18

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Asn Glu Asp 
                165                 170                 175     


Gly Asn Gln Gly Cys Met Gly Leu Ser Cys Ile Val Met 
            180                 185                 


