                         SEQUENCE LISTING

<110>  SAHA, Saurabh
 
<120>  CANCER TREATMENTS USING COMBINATIONS OF EGFR AND ERK INHIBITORS

<130>  C065272/0375609

<140>  US 61/918,908
<141>  2013-12-20

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  5436
<212>  DNA
<213>  Homo sapiens

<400>  1
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc     60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg    120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa    180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac    240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta    300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg    360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg    420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat    480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt    540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc    600

ttttattgaa acatcagcaa agacaagaca gagagtggag gatgcttttt atacattggt    660

gagggagatc cgacaataca gattgaaaaa aatcagcaaa gaagaaaaga ctcctggctg    720

tgtgaaaatt aaaaaatgca ttataatgta atctgggtgt tgatgatgcc ttctatacat    780

tagttcgaga aattcgaaaa cataaagaaa agatgagcaa agatggtaaa aagaagaaaa    840

agaagtcaaa gacaaagtgt gtaattatgt aaatacaatt tgtacttttt tcttaaggca    900

tactagtaca agtggtaatt tttgtacatt acactaaatt attagcattt gttttagcat    960

tacctaattt ttttcctgct ccatgcagac tgttagcttt taccttaaat gcttatttta   1020

aaatgacagt ggaagttttt ttttcctcta agtgccagta ttcccagagt tttggttttt   1080

gaactagcaa tgcctgtgaa aaagaaactg aatacctaag atttctgtct tggggttttt   1140

ggtgcatgca gttgattact tcttattttt cttaccaatt gtgaatgttg gtgtgaaaca   1200

aattaatgaa gcttttgaat catccctatt ctgtgtttta tctagtcaca taaatggatt   1260

aattactaat ttcagttgag accttctaat tggtttttac tgaaacattg agggaacaca   1320

aatttatggg cttcctgatg atgattcttc taggcatcat gtcctatagt ttgtcatccc   1380

tgatgaatgt aaagttacac tgttcacaaa ggttttgtct cctttccact gctattagtc   1440

atggtcactc tccccaaaat attatatttt ttctataaaa agaaaaaaat ggaaaaaaat   1500

tacaaggcaa tggaaactat tataaggcca tttccttttc acattagata aattactata   1560

aagactccta atagcttttc ctgttaaggc agacccagta tgaaatgggg attattatag   1620

caaccatttt ggggctatat ttacatgcta ctaaattttt ataataattg aaaagatttt   1680

aacaagtata aaaaattctc ataggaatta aatgtagtct ccctgtgtca gactgctctt   1740

tcatagtata actttaaatc ttttcttcaa cttgagtctt tgaagatagt tttaattctg   1800

cttgtgacat taaaagatta tttgggccag ttatagctta ttaggtgttg aagagaccaa   1860

ggttgcaagg ccaggccctg tgtgaacctt tgagctttca tagagagttt cacagcatgg   1920

actgtgtccc cacggtcatc cagtgttgtc atgcattggt tagtcaaaat ggggagggac   1980

tagggcagtt tggatagctc aacaagatac aatctcactc tgtggtggtc ctgctgacaa   2040

atcaagagca ttgcttttgt ttcttaagaa aacaaactct tttttaaaaa ttacttttaa   2100

atattaactc aaaagttgag attttggggt ggtggtgtgc caagacatta attttttttt   2160

taaacaatga agtgaaaaag ttttacaatc tctaggtttg gctagttctc ttaacactgg   2220

ttaaattaac attgcataaa cacttttcaa gtctgatcca tatttaataa tgctttaaaa   2280

taaaaataaa aacaatcctt ttgataaatt taaaatgtta cttattttaa aataaatgaa   2340

gtgagatggc atggtgaggt gaaagtatca ctggactagg aagaaggtga cttaggttct   2400

agataggtgt cttttaggac tctgattttg aggacatcac ttactatcca tttcttcatg   2460

ttaaaagaag tcatctcaaa ctcttagttt ttttttttta caactatgta atttatattc   2520

catttacata aggatacact tatttgtcaa gctcagcaca atctgtaaat ttttaaccta   2580

tgttacacca tcttcagtgc cagtcttggg caaaattgtg caagaggtga agtttatatt   2640

tgaatatcca ttctcgtttt aggactcttc ttccatatta gtgtcatctt gcctccctac   2700

cttccacatg ccccatgact tgatgcagtt ttaatacttg taattcccct aaccataaga   2760

tttactgctg ctgtggatat ctccatgaag ttttcccact gagtcacatc agaaatgccc   2820

tacatcttat ttcctcaggg ctcaagagaa tctgacagat accataaagg gatttgacct   2880

aatcactaat tttcaggtgg tggctgatgc tttgaacatc tctttgctgc ccaatccatt   2940

agcgacagta ggatttttca aacctggtat gaatagacag aaccctatcc agtggaagga   3000

gaatttaata aagatagtgc tgaaagaatt ccttaggtaa tctataacta ggactactcc   3060

tggtaacagt aatacattcc attgttttag taaccagaaa tcttcatgca atgaaaaata   3120

ctttaattca tgaagcttac tttttttttt tggtgtcaga gtctcgctct tgtcacccag   3180

gctggaatgc agtggcgcca tctcagctca ctgcaacctc catctcccag gttcaagcga   3240

ttctcgtgcc tcggcctcct gagtagctgg gattacaggc gtgtgccact acactcaact   3300

aatttttgta tttttaggag agacggggtt tcaccctgtt ggccaggctg gtctcgaact   3360

cctgacctca agtgattcac ccaccttggc ctcataaacc tgttttgcag aactcattta   3420

ttcagcaaat atttattgag tgcctaccag atgccagtca ccgcacaagg cactgggtat   3480

atggtatccc caaacaagag acataatccc ggtccttagg tagtgctagt gtggtctgta   3540

atatcttact aaggcctttg gtatacgacc cagagataac acgatgcgta ttttagtttt   3600

gcaaagaagg ggtttggtct ctgtgccagc tctataattg ttttgctacg attccactga   3660

aactcttcga tcaagctact ttatgtaaat cacttcattg ttttaaagga ataaacttga   3720

ttatattgtt tttttatttg gcataactgt gattctttta ggacaattac tgtacacatt   3780

aaggtgtatg tcagatattc atattgaccc aaatgtgtaa tattccagtt ttctctgcat   3840

aagtaattaa aatatactta aaaattaata gttttatctg ggtacaaata aacaggtgcc   3900

tgaactagtt cacagacaag gaaacttcta tgtaaaaatc actatgattt ctgaattgct   3960

atgtgaaact acagatcttt ggaacactgt ttaggtaggg tgttaagact tacacagtac   4020

ctcgtttcta cacagagaaa gaaatggcca tacttcagga actgcagtgc ttatgagggg   4080

atatttaggc ctcttgaatt tttgatgtag atgggcattt ttttaaggta gtggttaatt   4140

acctttatgt gaactttgaa tggtttaaca aaagatttgt ttttgtagag attttaaagg   4200

gggagaattc tagaaataaa tgttacctaa ttattacagc cttaaagaca aaaatccttg   4260

ttgaagtttt tttaaaaaaa gctaaattac atagacttag gcattaacat gtttgtggaa   4320

gaatatagca gacgtatatt gtatcatttg agtgaatgtt cccaagtagg cattctaggc   4380

tctatttaac tgagtcacac tgcataggaa tttagaacct aacttttata ggttatcaaa   4440

actgttgtca ccattgcaca attttgtcct aatatataca tagaaacttt gtggggcatg   4500

ttaagttaca gtttgcacaa gttcatctca tttgtattcc attgattttt tttttcttct   4560

aaacattttt tcttcaaaca gtatataact ttttttaggg gatttttttt tagacagcaa   4620

aaactatctg aagatttcca tttgtcaaaa agtaatgatt tcttgataat tgtgtagtaa   4680

tgttttttag aacccagcag ttaccttaaa gctgaattta tatttagtaa cttctgtgtt   4740

aatactggat agcatgaatt ctgcattgag aaactgaata gctgtcataa aatgaaactt   4800

tctttctaaa gaaagatact cacatgagtt cttgaagaat agtcataact agattaagat   4860

ctgtgtttta gtttaatagt ttgaagtgcc tgtttgggat aatgataggt aatttagatg   4920

aatttagggg aaaaaaaagt tatctgcaga tatgttgagg gcccatctct ccccccacac   4980

ccccacagag ctaactgggt tacagtgttt tatccgaaag tttccaattc cactgtcttg   5040

tgttttcatg ttgaaaatac ttttgcattt ttcctttgag tgccaatttc ttactagtac   5100

tatttcttaa tgtaacatgt ttacctggaa tgtattttaa ctatttttgt atagtgtaaa   5160

ctgaaacatg cacattttgt acattgtgct ttcttttgtg ggacatatgc agtgtgatcc   5220

agttgttttc catcatttgg ttgcgctgac ctaggaatgt tggtcatatc aaacattaaa   5280

aatgaccact cttttaattg aaattaactt ttaaatgttt ataggagtat gtgctgtgaa   5340

gtgatctaaa atttgtaata tttttgtcat gaactgtact actcctaatt attgtaatgt   5400

aataaaaata gttacagtga caaaaaaaaa aaaaaa                             5436


<210>  2
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  3
<211>  5312
<212>  DNA
<213>  Homo sapiens

<400>  3
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc     60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg    120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa    180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac    240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta    300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg    360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg    420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat    480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt    540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc    600

ttttattgaa acatcagcaa agacaagaca gggtgttgat gatgccttct atacattagt    660

tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa    720

gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact    780

agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc    840

taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat    900

gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac    960

tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gtttttggtg   1020

catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt   1080

aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt   1140

actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt   1200

tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat   1260

gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg   1320

tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca   1380

aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga   1440

ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac   1500

cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca   1560

agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat   1620

agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg   1680

tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt   1740

gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg   1800

tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg   1860

gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca   1920

agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat   1980

taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa   2040

caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa   2100

attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa   2160

aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga   2220

gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat   2280

aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa   2340

aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt   2400

tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt   2460

acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa   2520

tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc   2580

cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta   2640

ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca   2700

tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc   2760

actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg   2820

acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat   2880

ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt   2940

aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt   3000

aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg   3060

gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct   3120

cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt   3180

tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg   3240

acctcaagtg attcacccac cttggcctca taaacctgtt ttgcagaact catttattca   3300

gcaaatattt attgagtgcc taccagatgc cagtcaccgc acaaggcact gggtatatgg   3360

tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat   3420

cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa   3480

agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact   3540

cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat   3600

attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg   3660

tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt   3720

aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa   3780

ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt   3840

gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg   3900

tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat   3960

ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct   4020

ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga   4080

gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga   4140

agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat   4200

atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta   4260

tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg   4320

ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa   4380

gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac   4440

attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac   4500

tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt   4560

ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata   4620

ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt   4680

tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt   4740

gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt   4800

taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc   4860

acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt   4920

ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt   4980

tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga   5040

aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt   5100

gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg   5160

accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga   5220

tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata   5280

aaaatagtta cagtgacaaa aaaaaaaaaa aa                                 5312


<210>  4
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  5
<211>  661
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atgactgagt ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg     60

atacagctaa ttcagaatca ctttgtggat gaatatgatc ctacgataga ggactcctac    120

aggaaacaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt    180

caagaggagt acagtgcaat gagggaccag tacatgagaa ctggggaggg ctttctttgt    240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt    300

aaaagagtaa aggactctga agatgtgcct atggtcctag tagggaataa gtgtgacttg    360

ccttctagaa cagtagacac gaaacaggct caggagttag caaggagtta tgggattcca    420

ttcattgaga cctcagcgaa gacaagacag ggtgttgacg atgccttcta tacattagtc    480

cgagaaattc gaaaacataa agaaaagatg agcaaagatg ggaaaaagaa gaagaagaag    540

tcaaggacaa ggtgtatagt catgtgaata gtttgtactc tttcttaagg cacacttaag    600

taaagtgtga tttttgtaca ttacactaaa ttattagcat ttgttttagc attacctaat    660

c                                                                    661


<210>  6
<211>  188
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Arg Thr Arg Cys Ile Val Met 
            180                 185             


<210>  7
<211>  4670
<212>  DNA
<213>  Mus musculus

<400>  7
aggcggcggc cgcggcggct gaggcggcag cgctgtggcg gcggctgaga cggcagggga     60

aggcggcggc ggctcggccc ggagtcccgc tcccgcgcca tttcggaccc ggagcgagcg    120

cggcgcgggc ctgaaggcgg cggcgggagc ctgaggcgcg gcggctccgc ggcgcggaga    180

gaggcctgct gaaaatgact gagtataaac ttgtggtggt tggagctggt ggcgtaggca    240

agagcgcctt gacgatacag ctaattcaga atcactttgt ggatgagtat gaccctacga    300

tagaggactc ctacaggaaa caagtagtaa ttgatggaga aacctgtctc ttggatattc    360

tcgacacagc aggtcaagag gagtacagtg caatgaggga ccagtacatg agaactgggg    420

agggctttct ttgtgtattt gccataaata atactaaatc atttgaagat attcaccatt    480

atagagaaca aattaaaaga gtaaaggact ctgaagatgt gcctatggtc ctggtaggga    540

ataagtgtga tttgccttct agaacagtag acacgaaaca ggctcaggag ttagcaagga    600

gttacgggat tccgttcatt gagacctcag caaagacaag acagggtgtt gacgatgcct    660

tctatacatt agtccgagaa attcgaaaac ataaagaaaa gatgagcaaa gatgggaaga    720

agaagaagaa gaagtcaagg acaaggtgta cagttatgtg aatactttgt actctttctt    780

aaggcacact taagtaaaag tgtgattttt gtacattaca ctaaattatt agcatttgtt    840

ttagcattac ctaatctttt tttttcttct gttcgtgcaa actgtcagct tttatctcaa    900

atgcttattt taaaagaaca gtggaaacct tcttttttct aagtgccagt attccctggg    960

ttttggactt aaactagcaa tgcctgtgga agagactaaa gacctgagac tctgtcttgg   1020

gatttggtgc atgcagttga ttccttgcta gttctcttac caactgtgaa cactgatggg   1080

aagcaggata atgaagcttc cggaccatcc ctgctctgtg tccatctact catccaatgg   1140

agtcattagc agtcaatcgc cgcttcactg gacactgagg ggtcacagac ttaggctccc   1200

tttgagtcgc gtccagcgtg tcctagactt tatcatcttt cagaggcgta ggcagactgt   1260

tcacaaaggc tttctgtagc tttccactgc aattaatctt ggtcactccc tcaaatagta   1320

tattttttct agaaaagggg aaaaatggaa aaaaaaaggc aatggaaaat gttgaaatcc   1380

attcagtttc catgttagct aaattactgt aagattccta taatagcttt tcctggtaag   1440

gcagacccag tatgaaatag taataaccat ttgggctata tttacatgct actaaatttt   1500

tgtaataatt caaacaactt tagcatatat aaaaagttct cataagaatt aagtacaatt   1560

cccctttgtc agattgttct tatcctaact ttcaagtctt ttttgaattt ctgttgttga   1620

aagtagtttt aatggttgtg aagctgaaga tgatctgaga cagttatagc ttggcaggtg   1680

ttgaggagac cagagttgca gggttgggcc ttacgtgaac ctgtgacgaa cgctactggg   1740

ttttgcagca ctgctgcatt caatgttggc gacgcattgt ttggtcaaca taggggataa   1800

ggagactttg atggcttagt ataatgcatt ctcaccatgt aacagtccta ctgacaaatc   1860

aagaaatttg tttataataa taaaaaattt ttaaaaattt cgatgttcgc ttcaaggttg   1920

agattttggg gtaggaggct acaacaagag taaatcttaa agcaaggttt taagaaggtt   1980

tgaaaatgca ggtttgacta gtctctcaac tctagctaaa caaacattcc caagtacttc   2040

ccaaatctga taggtattta aaattatcta atgctttaag aatagttaac aggaaaaaaa   2100

tctcctcagt gcacttaaag caacccttca catcatttga aatgagatgg aaatatcact   2160

ggactatgag gactggatgt ctgtctgatt ttaagcaaat cactgtctgc ttggttttga   2220

atcatctcaa agacattaac ctcccagccg tgtaacatag tttacatgtt gacacaccta   2280

gttatcaagc tcagcacaat ctgtaactgt tttacatgga ttaacatctt cactgccagt   2340

cttgggcaaa ttgtgcaaga ggtaaaattt atatttcagt atccattctc ccatttcagg   2400

actcccctcc aacattatgc tggctttcag cctgtctctc acctgcccat cacttagtgt   2460

agttttaata atttccccca cttcaaactt tgtttccact atggacaact tcatgaactt   2520

tgcccactaa ggtaggtaca tcaaagctgc cctatggctt tcttccccgg gactgaaaat   2580

aacagacacc atagtgggat ttaaactaat agatggtttt cagggccact acaacaattc   2640

aatctcaatc ctttggactt cattcctgct gcccaggcca ctggtgcctc agtaggaatt   2700

ttcaaaatta gtgtgaacag acagagcaca gtccagtgga aggtgagctt aatcttcatc   2760

tagccatcat catggtaagt gatagattct attgttttaa taaatacagt ctaacaatga   2820

aaaacacttc gaagtttcaa tcataaagct gtctttttaa aaattttatt tactcaacat   2880

ttattcagtg cttgtcatat tctgggaatt acactaggca ctcagggtgc ggtgtcctca   2940

atccttggcc agtggtatgt agcatgatct gtaataccac taaataaggc atatagcata   3000

tgacttagac ataatgaaat acatgatttg agttttgcag agaggagttt gggtttgtac   3060

attcccttcc cccccagttt agcaagaatt gtttgctgtg aatccaatgc aacttttaaa   3120

tcaaactact ttatataatt atttcatttt tctaaaggaa cagaagtacc ctaaactatt   3180

tttttgaaat gttctaaact gtacatattc atagaacatt ctttgggtga attttaagtc   3240

ttaaaatgca attagtaata cttctcattt ctattcagag gaacaggtgt acttcaaaag   3300

ctgcagtgta taatcagata tttttaatgg acaatgtgtt aaagaagtgg taattaccac   3360

tatgtaaatt tgaattgtgt tacactttgg ttaacaaaag gggaaagaat cctagaaaca   3420

aatatgttat ctagttactg cagccttaaa gtccttgttg aagttaaaaa gcaatgctaa   3480

gttacagtca taggcattaa catgtttatg ggaaggatat agtaggcaaa tacaatttga   3540

gtaaatattt tcagtaggga attttaggct ctactgactg agtcacactg cataggaatt   3600

tagatcttaa cttttatagg ttatcgacct ttgccaccat tgcacaattt tgtcctaaca   3660

taaatacaag ttctgtgagg catgtcaaaa gttacagttt gcataaattc atctcatttt   3720

gtattccact gattttacat tttcctcaaa catacataca tacatacata caacacacac   3780

acactcacac atgaagggtt ttttttttgt aggcaataaa aatttaacta atttccattt   3840

gttaaaaagt agtgatttat tgagaattat gcagtcattt tttaaaccca aaagttattt   3900

aaaggtgaat ttatactcaa taacttctgt gtaatactgg gtagcatgaa ttctgcattg   3960

aaaaattgaa cagataatac caatagctgt aaattctgtc aaaacatgaa aattatttct   4020

aaagaagtac attagttttc aaagaacagt tattagaatc agatctgtgg tttagttcaa   4080

taatttgaag tgcctgtttg ggatggtggt aggcatttta gatgaatttg ggaaaaataa   4140

agttctgcag aaatgccagt ttcagacccc gctaacccgc tgagtgggct gtgtgctgtg   4200

ttagctccag tgccccaatc ccgtttcatg tcttcatgtt gaaacacttc tgcattttta   4260

tttgagtgcc aatttcttac tagtgctatt tcttagtgta acatgtttac ctgggatgta   4320

ttttaactat ttttgtatag tgtaaactga aacatgcaca ttttgtacat tgtgctttcc   4380

ttctttccat tccttttctt tctgttttgt ttgtttgttt gtttgtttgt ttgttatggg   4440

acatatgcag tgtgatccag ttgttttcca tcctttggtt gcgctgacct agggaatgtt   4500

ggtcatatca aacattaaat ttaaaagtga ccactcttaa ttaaaattaa cttttaaatg   4560

tttataggag tacgtgctgt gaagtgatct gaaatttgta atatttttgt catgaaccgt   4620

actgctccta atcattgtaa tgtaataaaa atagttatgg tgactatgaa              4670


<210>  8
<211>  188
<212>  PRT
<213>  Mus musculus

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Arg Thr Arg Cys Thr Val Met 
            180                 185             


<210>  9
<211>  2068
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  9
acacacgcgc ccacccagcc acccggccac cagccgccat gggcaaggac aggcagcccc     60

gcgggcagca gaggcagggg gacgccgccg ggcccgacga cccggggccg aagaaaggcg    120

ccgggacccg cgagcagcgc ggggaggagg aggcccagac gtgctgcggc tgccgcttcc    180

cgctgctgct cgcgctgctg cagctggccc tgggcgtcgc cgtgaccgtg gtgggcttcc    240

tcatggcgag cgtcagctcc tccctgctag tcagagccac tccatattgg gctgggatca    300

ttgtctgcgt ggtggcctat cttggcttgt ttatgctttg tgtctcgtac caagttgatg    360

aacggacgtg tatccagttt tctatgaaac tgctgtactt cgtgctgagc gccctggggc    420

tggtggtgtg cgtgctggcc gtggccttcg ccgcccacca ctactcgctg ctcacgcacc    480

tgacctgtga gaacgccccc gactcctgcc agtgcaagct gccgtcctcg gagccgctga    540

gccggacctt cgtgtaccgg gatgtgactg actgtaccag catcacgggc accttccagg    600

tgttcctgct cgtccagatg gttctgaact tggtctgtgg ccttgtgtgc ttggtggcct    660

gctttgtgat gtggaaacac aggtatcagg tcttttatgt gggggtcagg atgtgccccc    720

tgtcggcttc cgaaggccag cagcagaagg tgtaggaatc ttgctcagaa ttgggagaga    780

aaatggcaca ctggctagct gaggttaaaa agaaaaatta tttttaagga gaaagagaga    840

aaacttttgc caatatttac tgctctaaat gaatattttt tatatttttc aagaaacaaa    900

agagcatttc ttcaggtttc tattgtattt ttaaacattc gtataggttc aacaagatac    960

acattgattt gcgggatatt caaagtcaaa agcacaccaa actgggaagc aatggcacag   1020

aactgtcctc acagtctggg gtttactctt catgctcact ttcgccacca ctgacgtacg   1080

gctttctggt taatacggtc taaggtttgt agtggctgcc ccaggtcctt cccgcctcct   1140

accacaatcc cccactgcgt cttagagaaa ggcaaggtgt ggagaagtca ctgggcaacc   1200

aggtggaatc tcttcatttc ccctactgcg gatgttgtca aggcccaaaa catgagcgaa   1260

cttcaaaaac ctcatgggaa gtggagttcg aagtttattt tgctgccaaa aaattaagat   1320

ccacacatat atagggatct tcagaaagtt cacagaaaat gcataatatg ggaaaaaaaa   1380

agattcacgg atttcagaat tttgtttgga ccaaactaaa gttatctttt aatgccattt   1440

ctgaagtgcc ctcatagctt ggaaagccaa gcagaaaaga ggctttgcaa aaatacaagt   1500

aattataaac acctgggcca gggcggctgt ctcagctgcc ttcgcttggc tctgtacgta   1560

gatcactcgc gcggggcttg gcagggctct ctgcttctca ataattgaaa tatggtggta   1620

gttgtattct taatgatgta gaaggtttaa aaataattac attacgcttc cattctatca   1680

tctacaacaa atcattcaac ctaatttcta gctaattgtt aattataatt atgctcagaa   1740

gtctatttaa tgagctctgg ctgtacttag gcagctctgc cagtgtaaag agaaattatt   1800

ctcgtaagag aagaggccta aagattcttt cttctgaaag tcaagcgtta taagggaaaa   1860

ctttttttta attaatagct caggataaaa acaccaattt aaacaaaaac aagagcattt   1920

ataataggaa gtacttgtac aaatagcacg tttgtggcac attgcagagt gtctctcttt   1980

gcagctaaat agctttgaag aaggctggcg agtgcagatg tattctgtgc acaaaactgt   2040

atttggctca taaccctatt attgattc                                      2068


<210>  10
<211>  238
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Met Gly Lys Asp Arg Gln Pro Arg Gly Gln Gln Arg Gln Gly Asp Ala 
1               5                   10                  15      


Ala Gly Pro Asp Asp Pro Gly Pro Lys Lys Gly Ala Gly Thr Arg Glu 
            20                  25                  30          


Gln Arg Gly Glu Glu Glu Ala Gln Thr Cys Cys Gly Cys Arg Phe Pro 
        35                  40                  45              


Leu Leu Leu Ala Leu Leu Gln Leu Ala Leu Gly Val Ala Val Thr Val 
    50                  55                  60                  


Val Gly Phe Leu Met Ala Ser Val Ser Ser Ser Leu Leu Val Arg Ala 
65                  70                  75                  80  


Thr Pro Tyr Trp Ala Gly Ile Ile Val Cys Val Val Ala Tyr Leu Gly 
                85                  90                  95      


Leu Phe Met Leu Cys Val Ser Tyr Gln Val Asp Glu Arg Thr Cys Ile 
            100                 105                 110         


Gln Phe Ser Met Lys Leu Leu Tyr Phe Val Leu Ser Ala Leu Gly Leu 
        115                 120                 125             


Val Val Cys Val Leu Ala Val Ala Phe Ala Ala His His Tyr Ser Leu 
    130                 135                 140                 


Leu Thr His Leu Thr Cys Glu Asn Ala Pro Asp Ser Cys Gln Cys Lys 
145                 150                 155                 160 


Leu Pro Ser Ser Glu Pro Leu Ser Arg Thr Phe Val Tyr Arg Asp Val 
                165                 170                 175     


Thr Asp Cys Thr Ser Ile Thr Gly Thr Phe Gln Val Phe Leu Leu Val 
            180                 185                 190         


Gln Met Val Leu Asn Leu Val Cys Gly Leu Val Cys Leu Val Ala Cys 
        195                 200                 205             


Phe Val Met Trp Lys His Arg Tyr Gln Val Phe Tyr Val Gly Val Arg 
    210                 215                 220                 


Met Cys Pro Leu Ser Ala Ser Glu Gly Gln Gln Gln Lys Val 
225                 230                 235             


<210>  11
<211>  1039
<212>  DNA
<213>  Cavia porcellus

<400>  11
ggtggcttct cggccagacc tcccggcccc cgccatttcg gaccgggagc cagcgcgacg     60

cgggcactga gggcggcggc gggggccaca ggctcggcgg ctcccaggtg cgggagagag    120

gcctgctgaa aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga    180

gtgccttgac gatacagcta attcagaatc actttgtgga tgaatatgat cctacaatag    240

aggattccta caggaaacaa gtagtaattg atggagaaac ctgtctcttg gatattctcg    300

acacagcagg tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg    360

gctttctttg tgtatttgcc ataaataata ctaaatcttt tgaagatatt caccattata    420

gagaacaaat taaaagagtt aaagactctg aagatgtacc tatggtccta gtaggaaata    480

aatgtgattt gccttctaga acagtagaca caaaacaagc tcaggactta gcaagaagtt    540

atggaattcc ttttattgaa acatcagcaa agacaagaca gagagtggag gatgcttttt    600

atacattggt gagagagatt cgacaataca gattgaaaaa aatcagcaaa gaagaaaaga    660

ctcctggctg tgtgaaaatt aaaaaatgca ttataatggg tgttgatgat gccttctata    720

cgttagttcg agaaattcga aaacataaag aaaagatgag caaagatggt aaaaagaaga    780

aaaagaagtc gaagacaaag tgtataatta tgtaaataca atttgtactt ttttcttaag    840

gcatacttaa gtaaaagtgg taatttttgt acattacact aaattattag cttttgtttt    900

agcattactt aattcttttc ctatttcatg caaactgtta gcttttatct taaatgctca    960

ttttaaaatg acagtggaaa ccttttattt cctcttaagt gccagtattc cctgcatttt   1020

ggtttttgaa ctagcaatg                                                1039


<210>  12
<211>  227
<212>  PRT
<213>  Cavia porcellus

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met Gly Val Asp 
            180                 185                 190         


Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
        195                 200                 205             


Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
    210                 215                 220                 


Ile Ile Met 
225         


<210>  13
<211>  835
<212>  DNA
<213>  Cavia porcellus

<400>  13
acaggctcgg cggctcccag gtgcgggaga gaggcctgct gaaaatgact gaatataaac     60

ttgtggtagt tggagctggt ggcgtaggca agagtgcctt gacgatacag ctaattcaga    120

atcactttgt ggatgaatat gatcctacaa tagaggattc ctacaggaaa caagtagtaa    180

ttgatggaga aacctgtctc ttggatattc tcgacacagc aggtcaagag gagtacagtg    240

caatgaggga ccagtacatg aggactgggg agggctttct ttgtgtattt gccataaata    300

atactaaatc ttttgaagat attcaccatt atagagaaca aattaaaaga gttaaagact    360

ctgaagatgt acctatggtc ctagtaggaa ataaatgtga tttgccttct agaacagtag    420

acacaaaaca agctcaggac ttagcaagaa gttatggaat tccttttatt gaaacatcag    480

caaagacaag acagggtgtt gatgatgcct tctatacgtt agttcgagaa attcgaaaac    540

ataaagaaaa gatgagcaaa gatggtaaaa agaagaaaaa gaagtcgaag acaaagtgta    600

taattatgta aatacaattt gtactttttt cttaaggcat acttaagtaa aagtggtaat    660

ttttgtacat tacactaaat tattagcttt tgttttagca ttacttaatt cttttcctat    720

ttcatgcaaa ctgttagctt ttatcttaaa tgctcatttt aaaatgacag tggaaacctt    780

ttatttcctc ttaagtgcca gtattccctg cattttggtt tttgaactag caatg         835


<210>  14
<211>  188
<212>  PRT
<213>  Cavia porcellus

<400>  14

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  15
<211>  4993
<212>  DNA
<213>  Canis lupus familiaris

<400>  15
gctgaaaatg actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc     60

cttgacgata cagctaattc agaatcactt tgtggatgaa tatgatccta caatagagga    120

ttcctacagg aaacaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac    180

agcaggtcaa gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt    240

tctttgtgta tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga    300

acaaattaaa agagttaaag actctgaaga tgtacctatg gtcctagtag gaaataaatg    360

tgatttgcct tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg    420

aattcctttt attgaaacat cagcaaagac aagacagaga gtggaggatg ctttttatac    480

attggtgaga gagatccgac aatacagatt gaaaaaaatc aacaaagaag aaaagactcc    540

tggctgtgtg aaaattaaaa aatgcattgt aatgggtgtt gacgatgcct tctatacatt    600

agttcgagaa attcgaaaac ataaagaaaa gatgagcaaa gatggtaaaa agaagaaaaa    660

gaagtcaaag acaaagtgta taattatgta aatacaattt gtactttttt cttaaggcat    720

acttaagtaa aagtggtaat ttttgtacat tacactaaat tattagcatt tgttttagca    780

ttacctaatt ttctgctcca tccaaactgt tagcttttat cttgaatgct tattttaaaa    840

tgacagtgga aactttttcc tctaagtgcc agtattccct gagttttggt tttgaactag    900

caatgcctgt gaaaaagaaa ctgaatacct gagatttctg tcttggggtt tttggtgcat    960

gcagttgatt acttcctatt tttcttacca attgtgaact ttggtgtgaa acaaattaat   1020

gaagctttcg aatcatccct attctgtgtt ttacctagtc acatacatgg attaattact   1080

aattataact tcagttgata tttcatgatt ggttttactg aaacattgag ggaacatgaa   1140

tttatgggct gcttcttata ggtataatgt cctatagttt cagtcaccct taatgaatgt   1200

aaagctacac tgttcacaaa ggttttctcc atcttttcac tgctatttgt catagccacg   1260

ctcccaaaaa tattatattt tttctataaa aaagggaaaa aatagaaaaa aatacaaggc   1320

aatggaaaat attaaaaggc atttactttc catattagat aaattcctat aatactctga   1380

atagcttttc ctgttaaggc agacccagta tgtaatgagg attatagcaa ccattttggg   1440

gctatattta catgctacta aatttttgta ttaattgaaa aagttttaac atgtataaaa   1500

aattcccata ggaattaaat atagtctccc tgtgtcagat tgctctttct tagcataact   1560

ttaaatcttt tcttgatctt caatcttaga aaatagtttt aattcttgta gtgatgttaa   1620

agattatttg ggccagttag tttttaatag atgttaaaga gaccacagtt ccaaggccag   1680

gccttgtgtg aacctttaag cttcattaag agtttcatag tacagactgc atccctgtgg   1740

tctcccaggg tcatcatgca ttgattgggt ggtcaaaagt ggggacaaag agtgtttaga   1800

taagatgcat cctcactgta tggtggtcct gctgacagat caggaccatc acttttgttt   1860

tttaaaaaac caacagagct ttttaaaaac attatttaaa atgagatttt tgggggcagg   1920

gggtggcaag acttgaattt tttttaaaca atgaagtaaa aaggtttcaa aatctctagt   1980

gttggctagt tctcaacatt ggctaaagta acatttcata aacactttac aagtattggt   2040

ccatatttaa gaatatctaa tgcttaaata atagattaat aacaattctt tcagtgcatt   2100

taaaatgtat ttttaaatat ctgaagtgag atggtgtgtt gaggtgaaaa tatcactgga   2160

ctaggaggaa ggtgacttag attctagtta cgtgtctttt acaacttcag ttttgggcaa   2220

atcactcact atccatttct tcatgttaag tcatctcaaa ggctatatct agcatcaact   2280

atgtgattta cattcagttt acataaggat atacctattt gtcaatctca gcacaatctg   2340

taacttttta cctatgttct cttcagcgcc agtcttaggc aaagttgtgc aagaggtgag   2400

gtttattttt gagaatctga tctccggtag caggtactcc tctcccatgt tagtgtcatc   2460

ttgcctgcct accttctaca tgccccatga cttgatgctt tctaattccc cgaacctcaa   2520

gatgtagtgc tgctttggat atctccatga ggtaataagt cacattagtc aggctcaaca   2580

taatctgaca gatactgtag tgggatttga tctaatagct aattttcagg tggtaactgt   2640

atcaatttaa ttttgatctt ttgaacatca tctctgctac ctggtccatt agtgactaag   2700

taggaaaagt aggaattttc atatctgtga tgtgtagaca gaccctatcc agtagaagaa   2760

tttaataaat ttaattaata aatactgaaa gatttcctta gataatccaa aactaggact   2820

agccctggta acggtgatac attccattat tttaataagt aaaatcttct tacaatgaaa   2880

aatactttaa aatttaattc ataaagctta ctttttagca gaattcattt attcaacaaa   2940

tacttgagtg cctgctagat gccaggttct acacaaggca ccggggatat tatggtattc   3000

ccaacaaggg acataatccc tatccttaag tagtactgtt attttagagt ggtctgtagt   3060

atattagtga ggcatttggc acatgaccca gagataatat aatgcatatt ttagttttgc   3120

acagaaggga tatggtctct aaggtttttt ccagctctaa aataattgtt cgctctgatt   3180

ccaataaact gtttaatcaa gctactttat ataaatcact ttacttcatt attttaaaga   3240

agtaaacttg actatattgt tttttatttg ggataattat gtgattctgt tgggatactt   3300

atatagtaca cattaaattg tatgtcagat gataacatta aaattcccaa gtgtaatatt   3360

ctacttggtc tctgtgtatc ataattaaaa tagatttaaa tattgagttc aaaaatagtt   3420

ttatttatct gggtgtgaat aaacagatgc ctgaactaat tcacagaaaa ggaaacttct   3480

gtgtaaaaag tcagtccaat ttctgaaatg ctatgctaaa ctacaggttt atggaacatt   3540

agatagggtg ttaagacttt atatagtact tcctcttgtt tctatacaag agaaagaaat   3600

ggccatactt caggaattgc agtgcataac tgagggattt ttaggactct tgaatttttg   3660

atgtagccgg gcaacttttt ttaggcagtg gtaattatcc tttattatgt gaattttgaa   3720

tggtttgaca aaacgtttgt ttttgtagag attttaaaag gggagcgcta atcctagaaa   3780

taaatattat gtaattatta cggccttaaa gataaaaatc cttgttgaaa gttgaaaaaa   3840

attgctaaat tacatagtct tagacattaa catgtttgtg gaagaatgta gcagaggtat   3900

gtagtataat ttgagtgaat attcccaatt aggaattcta ggctctagtt taactgagtc   3960

acactgcata ggaatttaga acctaacttc taggttatca aaatctttgc caccattgca   4020

caattttgtc ctaatatata gagaaacttt gtgaggcatg ttcagttgcg gtttgcacaa   4080

gttcatctca tttgtattcc agtgattttt tttcttctaa ccattttttt aaacaacatg   4140

tacacattgt tttttttggt aggcaatgaa aactgtcatt tccattgtca aacagtaatt   4200

cctcgataac tgtattaatg gtttttaaaa aaccatcagt tactttaaaa ctgaatttat   4260

atttaataac ttctgtatta gtattgggta gcatgaaatc tctattgaga aattgaacag   4320

catacaacta gtagctgtaa attccttcag aaagtgaaaa ttatttcttc ctaaagatat   4380

cttgacatca gtgcttgaag aatagtcata actagattaa taattgtttt agttaaacag   4440

ttttaagtgc ctgtttcaga tgatgatagg caatttagat gaatttagga aaaatcaaag   4500

tttttacttg cagaaatgtc cattataggg ggcccccctc ctcatagagc tgaatgggtt   4560

atgtaatgtt ttatccaaaa gtttccaatt ccactgtctt gtgttttcat gttgaaaata   4620

cttttgcatt tttcctttga gtgccaattt cttactagta ctatttctta atgtaacatg   4680

tttacctgga atgtatttta actatttttg tatagtgtaa actgaaacat gcacattttg   4740

tacattgtgc ttttttttgt gggacatatg cagtgtgatc cagttgtttt ccatcatttg   4800

gttgcgctga cctaggaatg ttggtcatat caaacattaa atttaaaaat gaccactctt   4860

ttaattaaaa ttaactttta aatgtttata ggagtatgtg ctgtgaagtg atctgaaatt   4920

tgtaatattt ttgtcatgaa ctgtactgct cctaattatt gtaatgtaat aaaaatagtt   4980

atggtgacta tga                                                      4993


<210>  16
<211>  227
<212>  PRT
<213>  Canis lupus familiaris

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Asn Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Val Met Gly Val Asp 
            180                 185                 190         


Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
        195                 200                 205             


Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
    210                 215                 220                 


Ile Ile Met 
225         


<210>  17
<211>  4876
<212>  DNA
<213>  Canis lupus familiaris

<400>  17
gctgaaaatg actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc     60

cttgacgata cagctaattc agaatcactt tgtggatgaa tatgatccta caatagagga    120

ttcctacagg aaacaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac    180

agcaggtcaa gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt    240

tctttgtgta tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga    300

acaaattaaa agagttaaag actctgaaga tgtacctatg gtcctagtag gaaataaatg    360

tgatttgcct tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg    420

aattcctttt attgaaacat cagcaaagac aagacagggt gttgacgatg ccttctatac    480

attagttcga gaaattcgaa aacataaaga aaagatgagc aaagatggta aaaagaagaa    540

aaagaagtca aagacaaagt gtataattat gtaaatacaa tttgtacttt tttcttaagg    600

catacttaag taaaagtggt aatttttgta cattacacta aattattagc atttgtttta    660

gcattaccta attttctgct ccatccaaac tgttagcttt tatcttgaat gcttatttta    720

aaatgacagt ggaaactttt tcctctaagt gccagtattc cctgagtttt ggttttgaac    780

tagcaatgcc tgtgaaaaag aaactgaata cctgagattt ctgtcttggg gtttttggtg    840

catgcagttg attacttcct atttttctta ccaattgtga actttggtgt gaaacaaatt    900

aatgaagctt tcgaatcatc cctattctgt gttttaccta gtcacataca tggattaatt    960

actaattata acttcagttg atatttcatg attggtttta ctgaaacatt gagggaacat   1020

gaatttatgg gctgcttctt ataggtataa tgtcctatag tttcagtcac ccttaatgaa   1080

tgtaaagcta cactgttcac aaaggttttc tccatctttt cactgctatt tgtcatagcc   1140

acgctcccaa aaatattata ttttttctat aaaaaaggga aaaaatagaa aaaaatacaa   1200

ggcaatggaa aatattaaaa ggcatttact ttccatatta gataaattcc tataatactc   1260

tgaatagctt ttcctgttaa ggcagaccca gtatgtaatg aggattatag caaccatttt   1320

ggggctatat ttacatgcta ctaaattttt gtattaattg aaaaagtttt aacatgtata   1380

aaaaattccc ataggaatta aatatagtct ccctgtgtca gattgctctt tcttagcata   1440

actttaaatc ttttcttgat cttcaatctt agaaaatagt tttaattctt gtagtgatgt   1500

taaagattat ttgggccagt tagtttttaa tagatgttaa agagaccaca gttccaaggc   1560

caggccttgt gtgaaccttt aagcttcatt aagagtttca tagtacagac tgcatccctg   1620

tggtctccca gggtcatcat gcattgattg ggtggtcaaa agtggggaca aagagtgttt   1680

agataagatg catcctcact gtatggtggt cctgctgaca gatcaggacc atcacttttg   1740

ttttttaaaa aaccaacaga gctttttaaa aacattattt aaaatgagat ttttgggggc   1800

agggggtggc aagacttgaa ttttttttaa acaatgaagt aaaaaggttt caaaatctct   1860

agtgttggct agttctcaac attggctaaa gtaacatttc ataaacactt tacaagtatt   1920

ggtccatatt taagaatatc taatgcttaa ataatagatt aataacaatt ctttcagtgc   1980

atttaaaatg tatttttaaa tatctgaagt gagatggtgt gttgaggtga aaatatcact   2040

ggactaggag gaaggtgact tagattctag ttacgtgtct tttacaactt cagttttggg   2100

caaatcactc actatccatt tcttcatgtt aagtcatctc aaaggctata tctagcatca   2160

actatgtgat ttacattcag tttacataag gatataccta tttgtcaatc tcagcacaat   2220

ctgtaacttt ttacctatgt tctcttcagc gccagtctta ggcaaagttg tgcaagaggt   2280

gaggtttatt tttgagaatc tgatctccgg tagcaggtac tcctctccca tgttagtgtc   2340

atcttgcctg cctaccttct acatgcccca tgacttgatg ctttctaatt ccccgaacct   2400

caagatgtag tgctgctttg gatatctcca tgaggtaata agtcacatta gtcaggctca   2460

acataatctg acagatactg tagtgggatt tgatctaata gctaattttc aggtggtaac   2520

tgtatcaatt taattttgat cttttgaaca tcatctctgc tacctggtcc attagtgact   2580

aagtaggaaa agtaggaatt ttcatatctg tgatgtgtag acagacccta tccagtagaa   2640

gaatttaata aatttaatta ataaatactg aaagatttcc ttagataatc caaaactagg   2700

actagccctg gtaacggtga tacattccat tattttaata agtaaaatct tcttacaatg   2760

aaaaatactt taaaatttaa ttcataaagc ttacttttta gcagaattca tttattcaac   2820

aaatacttga gtgcctgcta gatgccaggt tctacacaag gcaccgggga tattatggta   2880

ttcccaacaa gggacataat ccctatcctt aagtagtact gttattttag agtggtctgt   2940

agtatattag tgaggcattt ggcacatgac ccagagataa tataatgcat attttagttt   3000

tgcacagaag ggatatggtc tctaaggttt tttccagctc taaaataatt gttcgctctg   3060

attccaataa actgtttaat caagctactt tatataaatc actttacttc attattttaa   3120

agaagtaaac ttgactatat tgttttttat ttgggataat tatgtgattc tgttgggata   3180

cttatatagt acacattaaa ttgtatgtca gatgataaca ttaaaattcc caagtgtaat   3240

attctacttg gtctctgtgt atcataatta aaatagattt aaatattgag ttcaaaaata   3300

gttttattta tctgggtgtg aataaacaga tgcctgaact aattcacaga aaaggaaact   3360

tctgtgtaaa aagtcagtcc aatttctgaa atgctatgct aaactacagg tttatggaac   3420

attagatagg gtgttaagac tttatatagt acttcctctt gtttctatac aagagaaaga   3480

aatggccata cttcaggaat tgcagtgcat aactgaggga tttttaggac tcttgaattt   3540

ttgatgtagc cgggcaactt tttttaggca gtggtaatta tcctttatta tgtgaatttt   3600

gaatggtttg acaaaacgtt tgtttttgta gagattttaa aaggggagcg ctaatcctag   3660

aaataaatat tatgtaatta ttacggcctt aaagataaaa atccttgttg aaagttgaaa   3720

aaaattgcta aattacatag tcttagacat taacatgttt gtggaagaat gtagcagagg   3780

tatgtagtat aatttgagtg aatattccca attaggaatt ctaggctcta gtttaactga   3840

gtcacactgc ataggaattt agaacctaac ttctaggtta tcaaaatctt tgccaccatt   3900

gcacaatttt gtcctaatat atagagaaac tttgtgaggc atgttcagtt gcggtttgca   3960

caagttcatc tcatttgtat tccagtgatt ttttttcttc taaccatttt tttaaacaac   4020

atgtacacat tgtttttttt ggtaggcaat gaaaactgtc atttccattg tcaaacagta   4080

attcctcgat aactgtatta atggttttta aaaaaccatc agttacttta aaactgaatt   4140

tatatttaat aacttctgta ttagtattgg gtagcatgaa atctctattg agaaattgaa   4200

cagcatacaa ctagtagctg taaattcctt cagaaagtga aaattatttc ttcctaaaga   4260

tatcttgaca tcagtgcttg aagaatagtc ataactagat taataattgt tttagttaaa   4320

cagttttaag tgcctgtttc agatgatgat aggcaattta gatgaattta ggaaaaatca   4380

aagtttttac ttgcagaaat gtccattata gggggccccc ctcctcatag agctgaatgg   4440

gttatgtaat gttttatcca aaagtttcca attccactgt cttgtgtttt catgttgaaa   4500

atacttttgc atttttcctt tgagtgccaa tttcttacta gtactatttc ttaatgtaac   4560

atgtttacct ggaatgtatt ttaactattt ttgtatagtg taaactgaaa catgcacatt   4620

ttgtacattg tgcttttttt tgtgggacat atgcagtgtg atccagttgt tttccatcat   4680

ttggttgcgc tgacctagga atgttggtca tatcaaacat taaatttaaa aatgaccact   4740

cttttaatta aaattaactt ttaaatgttt ataggagtat gtgctgtgaa gtgatctgaa   4800

atttgtaata tttttgtcat gaactgtact gctcctaatt attgtaatgt aataaaaata   4860

gttatggtga ctatga                                                   4876


<210>  18
<211>  188
<212>  PRT
<213>  Canis lupus familiaris

<400>  18

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  19
<211>  1394
<212>  DNA
<213>  Felis catus

<400>  19
gctgaaaatg actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc     60

cttgacgata cagctaattc agaatcactt tgtggatgaa tatgatccta caatagagga    120

ttcctacagg aaacaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac    180

agcaggtcaa gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt    240

tctttgcgta tttgccataa ataatactaa atcatttgaa gatattcacc actatagaga    300

acaaataaaa agagttaaag actctgaaga tgtacctatg gtcctagtag gaaataaatg    360

tgatttgcct tctagaacag tagatacaaa acaggctcag gacttagcaa gaagttatgg    420

aattcctttt attgaaacat cagcaaagac aagacagggt gttgacgatg ccttctatac    480

attagttcga gaaattcgaa aacataaaga aaagatgagc aaagatggta aaaagaagaa    540

aaagaagtca aagacaaagt gtataattat gtaaatacaa tttgtacttt tttcttaagg    600

catacttaag taaaagtggt aatttttgta cattacacta aattattagc atttgtttta    660

gcattaccta attttctgct ccatccaaac tgttagcttt tatcttgaat gcttatttta    720

aatgacagtg gaaacttttt ttcctctaag tgccagtatt ccctgagttt tggtttttga    780

actagcaatg cctgtgaaaa agaaactgaa tacctgagat ttctgtcttg gggtttttgg    840

tgcatgcagt tgattacttc ctatttttct taccaattgt gaactttggt gtgaaacaaa    900

ttaatgaaac tttcgaatca tccctattct gtgtttcatg tagtcacata catggattaa    960

ttactaatta taacttcagt tgagatttca tgattcgttt tactgaaaca ttgagggaac   1020

atgaatttat gggcttcttg tagattcatc ttgtaggtat taatgtccta tagtttcagt   1080

cacccttaat gaatgtaaag ttacactgtt cataaaagtt tctccatctt ttcactgctg   1140

tttgtcatcg tcacgctccc ccaaaatatt atattttttc tataaaaagg gaaaaaagga   1200

aaaaaataca aggcaatgga aaatattaaa aggcatttac tttctgtatt agataaattc   1260

ctataatact ctgaatagct tttcctgtta aggcagaccc agtatgtgat gaggattata   1320

gcaaccattt tggggctata tttacatgct actaaatttt tgtaataatt gaaaaaattt   1380

taacatgtat aaaa                                                     1394


<210>  20
<211>  188
<212>  PRT
<213>  Felis catus

<400>  20

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  21
<211>  1512
<212>  DNA
<213>  Felis catus

<400>  21
tgctgaaaat gactgaatat aaacttgtgg tagttggagc tggtggcgta ggcaagagtg     60

ccttgacgat acagctaatt cagaatcact ttgtggatga atatgatcct acaatagagg    120

attcctacag gaaacaagta gtaattgatg gagaaacctg tctcttggat attctcgaca    180

cagcaggtca agaggagtac agtgcaatga gggaccagta catgaggact ggggagggct    240

ttctttgcgt atttgccata aataatacta aatcatttga agatattcac cactatagag    300

aacaaataaa aagagttaaa gactctgaag atgtacctat ggtcctagta ggaaataaat    360

gtgatttgcc ttctagaaca gtagatacaa aacaggctca ggacttagca agaagttatg    420

gaattccttt tattgaaaca tcagcaaaga caagacagag agtggaggat gctttttata    480

cattggtgag agagatccga cagtacagat tgaaaaaaat caacaaagaa gaaaagactc    540

ctggctgtgt gaaaattaaa aaatgcattg taatgggtgt tgacgatgcc ttctatacat    600

tagttcgaga aattcgaaaa cataaagaaa agatgagcaa agatggtaaa aagaagaaaa    660

agaagtcaaa gacaaagtgt ataattatgt aaatacaatt tgtacttttt tcttaaggca    720

tacttaagta aaagtggtaa tttttgtaca ttacactaaa ttattagcat ttgttttagc    780

attacctaat tttctgctcc atccaaactg ttagctttta tcttgaatgc ttattttaaa    840

tgacagtgga aacttttttt cctctaagtg ccagtattcc ctgagttttg gtttttgaac    900

tagcaatgcc tgtgaaaaag aaactgaata cctgagattt ctgtcttggg gtttttggtg    960

catgcagttg attacttcct atttttctta ccaattgtga actttggtgt gaaacaaatt   1020

aatgaaactt tcgaatcatc cctattctgt gtttcatgta gtcacataca tggattaatt   1080

actaattata acttcagttg agatttcatg attcgtttta ctgaaacatt gagggaacat   1140

gaatttatgg gcttcttgta gattcatctt gtaggtatta atgtcctata gtttcagtca   1200

cccttaatga atgtaaagtt acactgttca taaaagtttc tccatctttt cactgctgtt   1260

tgtcatcgtc acgctccccc aaaatattat attttttcta taaaaaggga aaaaaggaaa   1320

aaaatacaag gcaatggaaa atattaaaag gcatttactt tctgtattag ataaattcct   1380

ataatactct gaatagcttt tcctgttaag gcagacccag tatgtgatga ggattatagc   1440

aaccattttg gggctatatt tacatgctac taaatttttg taataattga aaaaatttta   1500

acatgtataa aa                                                       1512


<210>  22
<211>  227
<212>  PRT
<213>  Felis catus

<400>  22

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Asn Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Val Met Gly Val Asp 
            180                 185                 190         


Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
        195                 200                 205             


Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
    210                 215                 220                 


Ile Ile Met 
225         


<210>  23
<211>  2144
<212>  DNA
<213>  Bos taurus

<400>  23
ggcggtggcg gcggcggcgg cggtggcggt ggcggttcgg ccagtactcc cggcccccgc     60

catttctgac tgggagcgag cgcggcgcag gcactgaagg cagcggcggg ggccagaggc    120

tcggcggctc ccaggtgagg gagagaggcc tgctgaaaat gactgaatat aaacttgtgg    180

tagttggagc tggtggcgta ggcaagagtg ccttgacgat acagctaatt cagaatcact    240

ttgtggatga atatgatcct acgatagagg attcctacag gaaacaagta gtaattgatg    300

gagaaacctg tctcttggat attctcgaca cagcaggtca agaggagtac agtgcaatga    360

gggaccagta catgaggact ggggagggct ttctttgtgt atttgccata aataatacta    420

aatcatttga agatattcac cattatagag aacaaataaa aagagttaaa gactctgaag    480

atgtacctat ggttctagta ggaaataaat gtgatttgcc ttctagaaca gtagacacaa    540

aacaggctca ggacttagca agaagttatg gaattccttt tattgaaaca tcagcaaaga    600

caagacaggg tgttgacgat gccttctata cattagttcg agaaattcga aaacataaag    660

aaaagatgag caaagatggt aaaaagaaga aaaagaagtc aaagacaaag tgtataatta    720

tgtaaataca atttgtactt ttttcttaag gcatacttaa gtaaaagtgg taatttttgt    780

atattacact aaattattag catttgtttt agcattatct aattttcttt ctgctccatc    840

catactgtta gcttttatct tgaatgctta ttttaaaatg acagtggaaa cttttttcct    900

ctaagtgcca gtattccctg cgttttggtt tttgaactag caatgcctgt gaaaaagaaa    960

ctgaacaccc aagatttttg tcttggggtt tttggtgcat gcagttgatt acttcctatt   1020

tttcttatca attgtgaact ttagtgtgaa acaaattaat gaggctttca aatcatccct   1080

attgtattgt tttatctagt cacacacatg gattaattac taattataac ttcagttgag   1140

atttcatgat tggttttact gaaacatcga gggaacatga atttatgggc ttcctatagt   1200

ttcatcttgt aggtatcatt gtcctatagt ttcagttacc cttaatgaat gtcaggttac   1260

actgttcaca aaggttttct tctttccact gctatttgtc aaatggtcac gttccctaaa   1320

atactatatt ttttctataa aaaaaagaaa aaaatggaaa aaaatacaag gcaatggaaa   1380

atattaaaag gccacttact ttccacatta ggtaaattcc tataatgctc tgaatagctt   1440

tttatgttaa ggcagaccca gtaggtaatg aggattagaa caagcatttt gggactatat   1500

ttacatgctt taaatttttg taataacaaa aaaattttaa catgtataaa gaattctcat   1560

aggaattaaa tacagtctcc ctgtgtcaga ttgctctttc ttagcataaa tctttttctt   1620

gaacttcaat ctttaaaagt agttttaatt ctactgatag tgatgtaaaa gattatttgg   1680

gccagttagc ttggtaggtg ttacagagac cagggtggca tagccgggcc ttgtgtgaac   1740

ctttaagcta catggagagt ttcacagtgt ggactgcatc cctgtggtct tccattgttg   1800

ccatgccttg gttggtcaaa aacaaggact tgcagagaga ttgaatagct cagcaaggta   1860

cattctcatt atgtcgtagt cctactcagg aacatcactt ttttaaaata aaaaacccca   1920

aaaaacagaa cttaaaaaaa aaaacaacat tattttaaat gagattttcg gtggggtgga   1980

aagattttaa ttttttttaa acgatgaaat gaaaaaatgt caaaatcttg agtattggct   2040

agttctcttt aacactggct aaagtaacat ttttgtaaac acttcagtac agtctggtcc   2100

attattaaga atatctaatg cttatacaat aaagtaatgc taac                    2144


<210>  24
<211>  188
<212>  PRT
<213>  Bos taurus

<400>  24

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  25
<211>  1010
<212>  DNA
<213>  Bos taurus

<400>  25
ggcggtggcg gcggcggcgg cggtggcggt ggcggttcgg ccagtactcc cggcccccgc     60

catttctgac tgggagcgag cgcggcgcag gcactgaagg cagcggcggg ggccagaggc    120

tcggcggctc ccaggtgagg gagagaggcc tgctgaaaat gactgaatat aaacttgtgg    180

tagttggagc tggtggcgta ggcaagagtg ccttgacgat acagctaatt cagaatcact    240

ttgtggatga atatgatcct acgatagagg attcctacag gaaacaagta gtaattgatg    300

gagaaacctg tctcttggat attctcgaca cagcaggtca agaggagtac agtgcaatga    360

gggaccagta catgaggact ggggagggct ttctttgtgt atttgccata aataatacta    420

aatcatttga agatattcac cattatagag aacaaataaa aagagttaaa gactctgaag    480

atgtacctat ggttctagta ggaaataaat gtgatttgcc ttctagaaca gtagacacaa    540

aacaggctca ggacttagca agaagttatg gaattccttt tattgaaaca tcagcaaaga    600

caagacagag agtggaggat gctttttata cattggtgag agagatccga caatacagat    660

tgaaaaaaat cagcaaagaa gaaaagactc ctggctgtgt gaaaattaaa aaatgcattg    720

taatgggtgt tgacgatgcc ttctatacat tagttcgaga aattcgaaaa cataaagaaa    780

agatgagcaa agatggtaaa aagaagaaaa agaagtcaaa gacaaagtgt ataattatgt    840

aaatacaatt tgtacttttt tcttaaggca tacttaagta aaagtggtaa tttttgtata    900

ttacactaaa ttattagcat ttgttttagc attatctaat tttctttctg ctccatccat    960

actgttagct tttatcttga atgcttattt taaaatgaca gtggaaactt              1010


<210>  26
<211>  227
<212>  PRT
<213>  Bos taurus

<400>  26

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Val Met Gly Val Asp 
            180                 185                 190         


Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
        195                 200                 205             


Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
    210                 215                 220                 


Ile Ile Met 
225         


<210>  27
<211>  797
<212>  DNA
<213>  Bos taurus

<400>  27
gcggtggcgg cggcggcggc ggtggcggtg gcggttcggc cagtactccc ggcccccgcc     60

atttctgact gggagcgagc gcggcgcagg cactgaaggc agcggcgggg gccagaggct    120

cggcggctcc caggtgaggg agagaggcct gctgaaaatg actgaatata aacttgtggt    180

agttggagct ggtggcgtag gcaagagtgc cttgacgata cagctaattc agaatcactt    240

tgtggatgaa tatgatccta cgatagagga ttcctacagg aaacaagtag taattgatgg    300

agaaacctgt ctcttggata ttctcgacac agcaggtcaa gaggagtaca gtgcaatgag    360

ggaccagtac atgaggactg gggagggctt tctttgtgta tttgccataa ataatactaa    420

atcatttgaa gatattcacc attatagaga acaaataaaa agagttaaag actctgaaga    480

tgtacctatg gttctagtag gaaataaatg tgatttgcct tctagaacag tagacacaaa    540

acaggctcag gacttagcaa gaagttatgg aattcctttt attgaaacat cagcaaagac    600

aagacagaga gtggaggatg ctttttatac attggtgaga gagatccgac aatacagatt    660

gaaaaaaatc agcaaagaag aaaagactcc tggctgtgtg aaaattaaaa aatgcattgt    720

aatgtaatct gggtgttgac gatgccttct atacattagt tcgagaaatt cgaaaacata    780

aagaaaagat gagcaaa                                                   797


<210>  28
<211>  189
<212>  PRT
<213>  Bos taurus

<400>  28

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Val Met 
            180                 185                 


<210>  29
<211>  1112
<212>  DNA
<213>  Gallus gallus

<400>  29
caggtctgct aaaaaatgac agagtataag cttgttgtcg ttggagctgg tggtgtgggc     60

aagagcgcct tgacaataca gctcattcag aaccactttg tggatgagta tgaccctacc    120

atagaggatt cctacagaaa gcaagtagta attgatgggg aaacctgtct cttggatatt    180

cttgatacag caggtcaaga agaatatagt gcaatgaggg accaatatat gagaacagga    240

gaaggctttc tgtgtgtttt tgctataaac aatacaaaat cttttgaaga tattcaccat    300

tatagggaac aaataaagag agttaaagac tctgaagatg tcccaatggt gctagtagga    360

aacaaatgtg atttgccttc cagaacagta gatacaaaac aagctcagga tttagcaaga    420

agttatggaa ttccttttat tgaaacatca gcaaagacaa gacagggtgt tgatgatgcc    480

ttctatacat tagttcgaga aatcagaaaa cacaaagaga agatgagcaa agatggtaaa    540

aagaagaaaa agaagacaaa gacaaagtgt ataattatgt aaatacaatg tatccttatt    600

cttaagacgt actgaagtaa tttttgtaca ttacactaaa ttattagcat ttgtttttag    660

cattacttta ctttctgctt catgatcctg ttagctttac ctgaatgctt gttttaaatg    720

acagtggaaa cttcattcct cttaaagtgc cagtattctt tgagtgttgg ttcttgaact    780

agcaatgcct gtgaagaaaa ataaaaacaa atgaaaaaaa aaaaaacaca caaaaacctg    840

agaactgtct taggactctt tggtgcatgc acagttgcta acttcctatt tttcttactg    900

attgtgaact tctgttccgt gcgtaaacaa aacaatgaaa cgatctacac gttctaacat    960

cccccttcat ttgtactctc ttatttttta catctggttg ggaaaacgga ccagttagtg   1020

acaaagactt tattttcaga cttccttcta atttcgactg actgcaatat agagagacca   1080

gaagccttta tagtcttcct gtagattttg ct                                 1112


<210>  30
<211>  188
<212>  PRT
<213>  Gallus gallus

<400>  30

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Thr Lys Thr Lys Cys Ile Ile Met 
            180                 185             


