                         SEQUENCE LISTING

<110>  Indiana University Research & Technology Corporation
       F. Hoffmann-La Roche AG
       Hoffmann-La Roche Inc.
       BELLI, Sara
       BLEICHER, Konrad
       DiMARCHI, Richard D.
       HOFFMANN, Eike
       KITAS, Eric A.
       KONKAR, Anish Ashok
 
<120>  Lipidated incretin receptor ligand human immunoglobulin Fc-region
        fusion polypeptides

<130>  32993-232708/31909 US-ASK

<140>  61/918,950
<141>  2013-12-20

<160>  125   

<170>  PatentIn version 3.3

<210>  1
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37)

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-36)

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-3

<400>  3

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4(1-31) desGlu(17) Tyr(32)

<400>  5

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Tyr 
            20                  25                  30      


<210>  6
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4(1-30) Tyr(31)

<400>  6

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Tyr 
            20                  25                  30      


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4(9-39)

<400>  7

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25                  30      


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa denotes Lys or Arg

<400>  8

Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val 
1               5                   10                  15      


Xaa Gly Arg 
            


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa denotes Lys or Arg

<400>  9

Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
1               5                   10                  15      


Val Xaa Gly Arg 
            20  


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa denotes Lys or Arg

<400>  10

Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp 
1               5                   10                  15      


Leu Val Xaa Gly Arg 
            20      


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes Lys or Arg

<400>  11

Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Xaa Gly Arg 
            20          


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa denotes Lys or Arg

<400>  12

Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile 
1               5                   10                  15      


Ala Trp Leu Val Xaa Gly Arg 
            20              


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa denotes Lys or Arg

<400>  13

Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe 
1               5                   10                  15      


Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa denotes Lys or Arg

<400>  14

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25  


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa denotes Lys or Arg

<400>  15

Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
1               5                   10                  15      


Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25      


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa denotes Lys or Arg

<400>  16

Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala 
1               5                   10                  15      


Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25          


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa denotes Lys or Arg

<400>  17

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25              


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa denotes Lys or Arg

<400>  18

Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa denotes Lys or Arg

<400>  19

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25                  30  


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa denotes Lys or Arg

<400>  20

His Asp Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
1               5                   10                  15      


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Arg 
            20                  25                  30      


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hybrid GLP-1/exendin polypeptide

<400>  21

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  22

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Lys 
        35          


<210>  23
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  23

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Lys 
            20                  25                  30      


<210>  24
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  24

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  25
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  25

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  26
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  26

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Glu Met Glu Glu 
1               5                   10                  15      


Glu Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Tyr 
            20                  25                  30      


<210>  27
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  27

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Glu Met Glu Glu 
1               5                   10                  15      


Glu Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Tyr 
            20                  25                  30  


<210>  28
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide

<400>  28

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Gly Gly Pro Ser Ser Gly Pro Pro Pro Ser 
            20                  25                  


<210>  29
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  29

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  30
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  30

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  31
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  31

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  32
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  32

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Gly 
            20                  25                  30      


<210>  33
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  33

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Gly 
            20                  25                  30      


<210>  34
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<400>  34

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  35
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  35

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  36
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<400>  36

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  37
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring between residues 16 and 20

<400>  37

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  38
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring between residues 16 and 20

<400>  38

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  39
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  incretin receptor ligand polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring between residues 16 and 20

<400>  39

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Trp Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Glu Ser Thr Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp 
65                  70                  75                  80  


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                85                  90                  95      


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105         


<210>  41
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  42
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  43
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with the mutations 
       L234A, L235A

<400>  43

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  44
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a hole mutation

<400>  44

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  45
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a knob mutation

<400>  45

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  46
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a L234A, L235A 
       and hole mutation

<400>  46

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  47
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a L234A, L235A 
       and knob mutation

<400>  47

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  48
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a P329G mutation

<400>  48

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  49
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a L234A, L235A 
       and P329G mutation

<400>  49

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  50
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a P239G and hole
       mutation

<400>  50

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  51
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a P329G and knob
       mutation

<400>  51

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  52
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a L234A, L235A, 
       P329G and hole mutation

<400>  52

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  53
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG1 isotype with a L234A, L235A, 
       P329G and knob mutation

<400>  53

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  54
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  55
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG4 isotype with a S228P and 
       L235E mutation

<400>  55

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  56
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant human Fc-region of the IgG4 isotype with a S228P, L235E 
       and P329G mutation

<400>  56

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Gly Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  57

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  58

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  59

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  60
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  60

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  63

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  64
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  64

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  65

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
1               5                   10          


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  66

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  67

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser 
            20                  


<210>  68
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G3-Fc

<400>  68

Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys 
225                 230 


<210>  69
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S3-Fc

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
1               5                   10                  15      


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  70
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  long incretin receptor ligand polypeptide with sortase tag


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa denotes aib

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa denotes serine amide

<400>  70

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Leu Pro Glu Thr Gly Gly Ser Gly 
        35                  40                  45              


Xaa 
    


<210>  71
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short incretin receptor ligand polypeptide with sortase tag


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  X=aib

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  X=serine amide

<400>  71

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Gly Leu 
            20                  25                  30          


Pro Glu Thr Gly Gly Ser Gly Ser 
        35                  40  


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sortase motif

<400>  72

Leu Pro Glu Thr Gly Gly Ser Gly Ser 
1               5                   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is an acidic amino acid such as Asp or Glu

<400>  73

Leu Pro Xaa Thr Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  74

Leu Pro Glu Thr Gly 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Leu Pro Xaa Thr Gly 
1               5   


<210>  76
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  77

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  78

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<400>  79

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  82

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  83

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  84

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  85

Gly Gly Gly Gly 
1               


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  86

Gly Gly Gly Gly Gly 
1               5   


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  87

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  88

Gly Gly Gly Ser 
1               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  89

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  90

Gly Gly Gly Gly Ser 
1               5   


<210>  91
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  91

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  92

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  93

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  94
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  94

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  95
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is AIB

<400>  95

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Leu Pro Glu Thr Gly Gly Gly Asp 
        35                  40                  45              


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    50                  55                  60                  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
65                  70                  75                  80  


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                85                  90                  95      


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            100                 105                 110         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        115                 120                 125             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    130                 135                 140                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
145                 150                 155                 160 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                165                 170                 175     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            180                 185                 190         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        195                 200                 205             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    210                 215                 220                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
225                 230                 235                 240 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                245                 250                 255     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            260                 265                 270         


Gly Lys 
        


<210>  96
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is AIB

<400>  96

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Gly Leu 
            20                  25                  30          


Pro Glu Thr Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265 


<210>  97
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is AIB

<400>  97

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Leu Pro Glu Thr Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
    50                  55                  60                  


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
65                  70                  75                  80  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                85                  90                  95      


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            100                 105                 110         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        115                 120                 125             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    130                 135                 140                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
145                 150                 155                 160 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                165                 170                 175     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            180                 185                 190         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        195                 200                 205             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    210                 215                 220                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
225                 230                 235                 240 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                245                 250                 255     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            260                 265                 270         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 285     


<210>  98
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is AIB

<400>  98

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Ala Trp Leu Leu Ala Gly Gly Gly Leu 
            20                  25                  30          


Pro Glu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    50                  55                  60                  


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
65                  70                  75                  80  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                85                  90                  95      


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            100                 105                 110         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        115                 120                 125             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    130                 135                 140                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
145                 150                 155                 160 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                165                 170                 175     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            180                 185                 190         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        195                 200                 205             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    210                 215                 220                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
225                 230                 235                 240 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                245                 250                 255     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            260                 265                 270         


Leu Ser Pro Gly Lys 
        275         


<210>  99
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  99

Gly Gly Gly 
1           


<210>  100
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X=gamma glutamic acid with palmytoic acid ester

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=cystein amide

<400>  100

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Xaa Xaa Ser Ile Tyr Leu 
1               5                   10                  15      


Asp Lys Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40          


<210>  101
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=desAmino Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X=cystein amide

<400>  101

Xaa Tyr Arg Ala Glu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr 
1               5                   10                  15      


Leu Asp Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly 
            20                  25                  30          


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40              


<210>  102
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X=cystein amide

<400>  102

Xaa Ala Leu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40      


<210>  103
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 4


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X=cystein amide

<400>  103

Xaa Ala Val Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40      


<210>  104
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-histidine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X=cystein amide

<400>  104

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40      


<210>  105
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 6


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetly-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X=cystein amide

<400>  105

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40      


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sortase tag acceptor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-bromoacetyl glycine

<400>  106

Xaa Gly Gly Leu Pro Glu Thr Gly Gly Ser Gly Ser 
1               5                   10          


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sortase tag acceptor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-bromoacetyl-leucine

<400>  107

Xaa Pro Glu Thr Gly Gly Ser Gly Ser 
1               5                   


<210>  108
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 7


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X=S-CH2-CO

<400>  108

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Xaa Xaa Ser Ile Tyr Leu 
1               5                   10                  15      


Asp Lys Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro 
        35                  40                  45              


Glu Thr Gly Gly Ser Gly Ser 
    50                  55  


<210>  109
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 8


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X=S-CH2-CO

<400>  109

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Xaa Xaa Ser Ile Tyr Leu 
1               5                   10                  15      


Asp Lys Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Leu Pro Glu Thr Gly 
        35                  40                  45              


Gly Ser Gly Ser 
    50          


<210>  110
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 9


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=deasAmino-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=S-CH2-CO

<400>  110

Xaa Ala Glu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro Glu 
        35                  40                  45              


Thr Gly Gly Ser Gly Ser 
    50                  


<210>  111
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 10


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=S-CH2-CO

<400>  111

Xaa Ala Leu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro Glu 
        35                  40                  45              


Thr Gly Gly Ser Gly Ser 
    50                  


<210>  112
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 11


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=S-CH2-CO

<400>  112

Xaa Ala Val Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro Glu 
        35                  40                  45              


Thr Gly Gly Ser Gly Ser 
    50                  


<210>  113
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 12


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-histidine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=S-CH2-CO

<400>  113

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro Glu 
        35                  40                  45              


Thr Gly Gly Ser Gly Ser 
    50                  


<210>  114
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 13


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X=S-CH2-CO

<400>  114

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Cys Xaa Gly Gly Gly Leu Pro Glu 
        35                  40                  45              


Thr Gly Gly Ser Gly Ser 
    50                  


<210>  115
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 14


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-histidine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  115

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Gly Gly Gly Leu 
            20                  25                  30          


Pro Glu Thr Gly Gly Ser Gly Ser 
        35                  40  


<210>  116
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipidated incretin receptor polypeptide 15


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  116

Xaa Ala Leu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Leu Pro Glu Thr Gly 
        35                  40                  45              


Gly Ser Gly Ser 
    50          


<210>  117
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  triple G human immunoglobulin IgG1 Fc-region with mutations 
       L234A, L235A, P329G

<400>  117

Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys 
225                 230 


<210>  118
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  long incretin receptor ligand polypeptide with sortase tag


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X=serine-amide

<400>  118

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Leu Pro Glu Thr Gly Gly Ser Gly 
        35                  40                  45              


Xaa 
    


<210>  119
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short incretin receptor ligand polypeptide with sortase tag


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X=serine amide

<400>  119

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Gly Leu 
            20                  25                  30          


Pro Glu Thr Gly Gly Ser Gly Xaa 
        35                  40  


<210>  120
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=aib

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X=gamma glutamic acid with palmytoic acid ester

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X=aib

<400>  120

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Xaa Xaa Ser Ile Tyr Leu 
1               5                   10                  15      


Asp Lys Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40      


<210>  121
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=desAmino Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  121

Xaa Tyr Arg Ala Glu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr 
1               5                   10                  15      


Leu Asp Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly 
            20                  25                  30          


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40          


<210>  122
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  122

Xaa Ala Leu Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  123
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 4


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  123

Xaa Ala Val Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  124
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetyl-d-histidine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  124

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  125
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isolated lipidated incretin receptor polypeptide 6


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=N-acetly-d-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X=gamma glutamic acid with palmitoic acid

<400>  125

Xaa Ala Gln Gly Thr Phe Thr Ser Asp Lys Xaa Ser Lys Tyr Leu Asp 
1               5                   10                  15      


Glu Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Glu Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


