                         SEQUENCE LISTING

<110>  Johns Hopkins Technology Transfer
 
<120>  MULTIEPITOPE FUSION ANTIGENS AND VACCINES AND THEIR USE IN 
       TREATMENT OF ENTEROTOXIGENIC DIARRHEA

<130>  P12168-01

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Ala Val Glu Asp Phe Phe Ile Val Pro 
            20                  25                  30          


Val Ser Gly Asp Pro Ala Ile Asp Leu Leu Gln Ala Asp Gly Asn Ala 
        35                  40                  45              


Leu Pro Ser Ala Val Lys Leu Ala Tyr Ser Pro Ala Ser Lys Thr Asn 
    50                  55                  60                  


Thr Leu Val Gly Val Leu Thr Leu Val His Thr Asn Asp Ala Thr Lys 
65                  70                  75                  80  


Lys Asn Val Leu Val Lys Leu Val Thr Pro Gln Leu Thr Asp Val Leu 
                85                  90                  95      


Asn Pro Thr Leu Gln Ile Pro Val Ser Val Gln Val Thr Val Tyr Pro 
            100                 105                 110         


Val Ser Thr Thr Ala Lys Glu Phe Glu Ala Ala Ala Leu Gly Tyr Ser 
        115                 120                 125             


Ala Ser Gly Val Asn Gly Leu Val Ser Ile Val Leu Thr Val Ile Ser 
    130                 135                 140                 


Ala Ala Pro Lys Thr Ala Gly Thr Ala Pro Thr Ala Gly Asn Tyr Ser 
145                 150                 155                 160 


Gly Val Val Ser Leu Val Met Thr Leu Gly Ala 
                165                 170     


<210>  2
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Ala Val Glu Asp Phe Phe Ile Val Pro 
            20                  25                  30          


Val Ser Gly Asp Pro Ala Ile Asp Leu Leu Gln Ala Asp Gly Asn Ala 
        35                  40                  45              


Leu Pro Ser Ala Val Lys Leu Ala Tyr Ser Pro Ala Ser Lys Thr Asn 
    50                  55                  60                  


Thr Leu Val Gly Val Leu Thr Leu Val His Thr Asn Asp Ala Thr Lys 
65                  70                  75                  80  


Lys Asn Val Leu Val Lys Leu Val Thr Pro Gln Leu Thr Asp Val Leu 
                85                  90                  95      


Asn Pro Thr Leu Gln Ile Pro Val Ser Val Gln Val Thr Val Tyr Pro 
            100                 105                 110         


Val Ser Thr Thr Ala Lys Glu Phe Glu Ala Ala Ala Leu Gly Tyr Ser 
        115                 120                 125             


Ala Ser Gly Val Asn Gly Leu Val Ser Ile Val Leu Thr Val Ile Ser 
    130                 135                 140                 


Ala Ala Pro Lys Thr Ala Gly Thr Ala Pro Thr Ala Gly Asn Tyr Ser 
145                 150                 155                 160 


Gly Val Val Ser Leu Val Met Thr Leu Gly Ala Phe Gly Val Ile Asp 
                165                 170                 175     


Glu Arg Leu His Arg Asn Arg Glu Tyr Arg Asp Arg Tyr Tyr Arg Asn 
            180                 185                 190         


Leu Asn Ile Ala Pro Ala Glu Asp Gly Tyr Arg Leu Ala Gly Phe Pro 
        195                 200                 205             


Pro Asp His Gln Ala Trp Arg Glu Glu Pro Trp Ile His His Ala Pro 
    210                 215                 220                 


Gln Gly Cys Gly Asn Ser Ser Gly Gly Pro Val Asp Met Asn Ser Ser 
225                 230                 235                 240 


Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Gln Cys Thr Gly Cys Tyr 
                245                 250                 255     


Thr Ile Thr Gly Asp Thr Cys Asn Glu Glu Thr Gln Asn Leu Ser Thr 
            260                 265                 270         


Ile Tyr Leu Arg Lys Tyr Gln Ser Lys Val Lys Arg Gln Ile Phe Ser 
        275                 280                 285             


Asp Tyr Gln Ser Glu Val Asp Ile Tyr Asn Arg Ile Arg Asn Glu Leu 
    290                 295                 300                 


Gly Pro Gly Pro Ala Pro Gln Ser Ile Thr Glu Leu Cys Ser Glu Tyr 
305                 310                 315                 320 


Arg Asn Thr Gln Ile Tyr Thr Ile Asn Asp Lys Ile Leu Ser Tyr Thr 
                325                 330                 335     


Glu Ser Met Ala Gly Lys Arg Glu Met Val Ile Ile Thr Phe Lys Ser 
            340                 345                 350         


Gly Ala Thr Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser 
        355                 360                 365             


Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Thr Tyr 
    370                 375                 380                 


Leu Thr Glu Thr Lys Ile Asp Lys Leu Cys Val Trp Asn Asn Lys Thr 
385                 390                 395                 400 


Pro Asn Ser Ile Ala Ala Ile Ser Asp Pro Arg Val Pro Ser Ser Met 
                405                 410                 415     


Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Gln Cys Thr 
            420                 425                 430         


Gly Cys Tyr 
        435 


<210>  3
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Ala Val Glu Asp Phe Phe Ile Val Pro 
            20                  25                  30          


Val Ser Gly Asp Pro Ala Ile Asp Leu Leu Gln Ala Asp Gly Asn Ala 
        35                  40                  45              


Leu Pro Ser Ala Val Lys Leu Ala Tyr Ser Pro Ala Ser Lys Thr Asn 
    50                  55                  60                  


Thr Leu Val Gly Val Leu Thr Leu Val His Thr Asn Asp Ala Thr Lys 
65                  70                  75                  80  


Lys Asn Val Leu Val Lys Leu Val Thr Pro Gln Leu Thr Asp Val Leu 
                85                  90                  95      


Asn Pro Thr Leu Gln Ile Pro Val Ser Val Gln Val Thr Val Tyr Pro 
            100                 105                 110         


Val Ser Thr Thr Ala Lys Glu Phe Glu Ala Ala Ala Leu Gly Tyr Ser 
        115                 120                 125             


Ala Ser Gly Val Asn Gly Leu Val Ser Ile Val Leu Thr Val Ile Ser 
    130                 135                 140                 


Ala Ala Pro Lys Thr Ala Gly Thr Ala Pro Thr Ala Gly Asn Tyr Ser 
145                 150                 155                 160 


Gly Val Val Ser Leu Val Met Thr Leu Gly Ala Phe Gly Val Ile Asp 
                165                 170                 175     


Glu Arg Leu His Arg Asn Arg Glu Tyr Arg Asp Arg Tyr Tyr Arg Asn 
            180                 185                 190         


Leu Asn Ile Ala Pro Ala Glu Asp Gly Tyr Arg Leu Ala Gly Phe Pro 
        195                 200                 205             


Pro Asp His Gln Ala Trp Arg Glu Glu Pro Trp Ile His His Ala Pro 
    210                 215                 220                 


Gln Gly Cys Gly Asn Ser Ser Gly Gly Pro Val Asp Met Asn Ser Ser 
225                 230                 235                 240 


Asn Tyr Cys Cys Glu Leu Cys Cys Ser Pro Ala Cys Thr Gly Cys Tyr 
                245                 250                 255     


Thr Ile Thr Gly Asp Thr Cys Asn Glu Glu Thr Gln Asn Leu Ser Thr 
            260                 265                 270         


Ile Tyr Leu Arg Lys Tyr Gln Ser Lys Val Lys Arg Gln Ile Phe Ser 
        275                 280                 285             


Asp Tyr Gln Ser Glu Val Asp Ile Tyr Asn Arg Ile Arg Asn Glu Leu 
    290                 295                 300                 


Gly Pro Gly Pro Ala Pro Gln Ser Ile Thr Glu Leu Cys Ser Glu Tyr 
305                 310                 315                 320 


Arg Asn Thr Gln Ile Tyr Thr Ile Asn Asp Lys Ile Leu Ser Tyr Thr 
                325                 330                 335     


Glu Ser Met Ala Gly Lys Arg Glu Met Val Ile Ile Thr Phe Lys Ser 
            340                 345                 350         


Gly Ala Thr Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser 
        355                 360                 365             


Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Thr Tyr 
    370                 375                 380                 


Leu Thr Glu Thr Lys Ile Asp Lys Leu Cys Val Trp Asn Asn Lys Thr 
385                 390                 395                 400 


Pro Asn Ser Ile Ala Ala Ile Ser Asp Pro Arg Val Pro Ser Ser Met 
                405                 410                 415     


Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Ser Pro Ala Cys Thr 
            420                 425                 430         


Gly Cys Tyr 
        435 


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Ser Gly Val Val Ser Leu Val Met Thr 
1               5                   


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Pro Thr Leu Gln Ile Pro Val Ser 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6

Leu Val Ser Ile Val Leu Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Asn Thr Leu Val Gly Val Leu Thr Leu 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Lys Asn Val Leu Val Lys Leu Val 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Asp Phe Phe Ile Val Pro Val Ser Gly 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Gln Val Thr Val Tyr Pro Val 
1               5           


<210>  11
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

Phe Gly Val Ile Asp Glu Arg Leu His Arg Asn Arg Glu Tyr Arg Asp 
1               5                   10                  15      


Arg Tyr Tyr Arg Asn Leu Asn Ile Ala Pro Ala Glu Asp Gly Tyr Arg 
            20                  25                  30          


Leu Ala Gly Phe Pro Pro Asp His Gln Ala Trp Arg Glu Glu Pro Trp 
        35                  40                  45              


Ile His His Ala Pro Gln Gly Cys Gly Asn Ser Ser Gly Thr Ile Thr 
    50                  55                  60                  


Gly Asp Thr Cys Asn Glu Glu Thr Gln Asn Leu Ser Thr Ile Tyr Leu 
65                  70                  75                  80  


Arg Lys Tyr Gln Ser Lys Val Lys Arg Gln Ile Phe Ser Asp Tyr Gln 
                85                  90                  95      


Ser Glu Val Asp Ile Tyr Asn Arg Ile Arg Asn Glu Leu 
            100                 105                 


<210>  12
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12

Ala Pro Gln Ser Ile Thr Glu Leu Cys Ser Glu Tyr Arg Asn Thr Gln 
1               5                   10                  15      


Ile Tyr Thr Ile Asn Asp Lys Ile Leu Ser Tyr Thr Glu Ser Met Ala 
            20                  25                  30          


Gly Lys Arg Glu Met Val Ile Ile Thr Phe Lys Ser Gly Ala Thr Phe 
        35                  40                  45              


Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala 
    50                  55                  60                  


Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Thr Tyr Leu Thr Glu Thr 
65                  70                  75                  80  


Lys Ile Asp Lys Leu Cys Val Trp Asn Asn Lys Thr Pro Asn Ser Ile 
                85                  90                  95      


Ala Ala Ile Ser 
            100 


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Gln Cys 
1               5                   10                  15      


Thr Gly Cys Tyr 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14

Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Ser Pro Ala Cys 
1               5                   10                  15      


Thr Gly Cys Tyr 
            20  


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  15
gtgagtgcta gcgcagtaga ggattttttc att                                    33


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  16
ctctcggccg ttatcaggct cccaaagtca ttacaag                                37


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  17
taatacgact cactataggg                                                   20


<210>  18
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18
accaaaggct cccaaagtca ttacaagaga tactactcct ga                          42


<210>  19
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19
gtaatgactt tgggagcctt tggtgtgatt gatgaacgat tacatcgt                    48


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  20
tgctagttat tggtcagggg t                                                 21


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21

Lys Asn Ile Thr Val Thr Ala Ser Val 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  22

Phe Glu Ser Tyr Arg Val Met Thr Gln 
1               5                   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  23

Lys Val Ile Val Lys Leu Ala Asp 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  24

Ser Thr Val Gln Met Pro Ile Ser 
1               5               


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  25

Ser Trp Gly Gly Gln Val Leu 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  26

Val Ser Ser Ser Gln Glu Leu 
1               5           


<210>  27
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  27
atgggcagca gccatcatna tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atggctagcg cagtagagga ttttttcatt gttccagttt ctggagatcc tgcaattgat      120

cttttgcaag ctgatggcaa tgctctgcca tcagctgtaa agttagctta ttctcccgca      180

tcaaaaacta atactttggt gggtgttttg actcttgtac atacaaacga tgcaactaaa      240

aaaaatgtac tagttaagct tgtaacacca cagcttacag atgttctgaa tccaaccctg      300

caaattcctg tttctgtgca ggtaacggtc taccctgttt ctacaacagc caaagaattt      360

gaagctgctg ctttgggata ttctgcatcc ggtgtaaatg gcttggtgtc aattgtgctt      420

actgtaatta gcgctgcacc taaaactgcc ggtaccgccc caactgcagg aaactattca      480

ggagtagtat ctcttgtaat gactttggga gcctgataa                             519


<210>  28
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  28
atgggcagca gccatcatna tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atggctagcg cagtagagga ttttttcatt gttccagttt ctggagatcc tgcaattgat      120

cttttgcaag ctgatggcaa tgctctgcca tcagctgtaa agttagctta ttctcccgca      180

tcaaaaacta atactttggt gggtgttttg actcttgtac atacaaacga tgcaactaaa      240

aaaaatgtac tagttaagct tgtaacacca cagcttacag atgttctgaa tccaaccctg      300

caaattcctg tttctgtgca ggtaacggtc taccctgttt ctacaacagc caaagaattt      360

gaagctgctg ctttgggata ttctgcatcc ggtgtaaatg gcttggtgtc aattgtgctt      420

actgtaatta gcgctgcacc taaaactgcc ggtaccgccc caactgcagg aaactattca      480

ggagtagtat ctcttgtaat gactttggga gcctttggtg tgattgatga acgattacat      540

cgtaacaggg aatatagaga ccggtattac agaaatctga atatagctcc ggcagaggat      600

ggttacagat tagcaggttt cccaccggat caccaagctt ggagagaaga accctggatt      660

catcatgcac cacaaggttg tggaaattca tcaggagggc cggtcgacat gaatagtagc      720

aattactgct gtgaattgtg ttgtaatcct cagtgtaccg ggtgctatac aattacaggt      780

gatacttgta atgaggagac ccagaatctg agcacaatat atctcaggaa atatcaatca      840

aaagttaaga ggcagatatt ttcagactat cagtcagagg ttgacatata taacagaatt      900

cggaatgaat tagggccggg gcccgctccc cagtctatta cagaactatg ttcggaatat      960

cgcaacacac aaatatatac gataaatgac aagatactat catatacgga atcgatggca     1020

ggcaaaagag aaatggttat cattacattt aagagcggcg caacatttca ggtcgaagtc     1080

ccgggcagtc aacatataga ctcccaaaaa aaagccattg aaaggatgaa ggacacatta     1140

agaatcacat atctgaccga gaccaaaatt gataaattat gtgtatggaa taataaaacc     1200

cccaattcaa ttgcggcaat cagtgatccc cgggtaccga gctcgatgaa tagtagcaat     1260

tactgctgtg aattgtgttg taatcctcag tgtaccgggt gctattaata acggccg        1317


<210>  29
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  29
atgggcagca gccatcatna tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atggctagcg cagtagagga ttttttcatt gttccagttt ctggagatcc tgcaattgat      120

cttttgcaag ctgatggcaa tgctctgcca tcagctgtaa agttagctta ttctcccgca      180

tcaaaaacta atactttggt gggtgttttg actcttgtac atacaaacga tgcaactaaa      240

aaaaatgtac tagttaagct tgtaacacca cagcttacag atgttctgaa tccaaccctg      300

caaattcctg tttctgtgca ggtaacggtc taccctgttt ctacaacagc caaagaattt      360

gaagctgctg ctttgggata ttctgcatcc ggtgtaaatg gcttggtgtc aattgtgctt      420

actgtaatta gcgctgcacc taaaactgcc ggtaccgccc caactgcagg aaactattca      480

ggagtagtat ctcttgtaat gactttggga gcctttggtg tgattgatga acgattacat      540

cgtaacaggg aatatagaga ccggtattac agaaatctga atatagctcc ggcagaggat      600

ggttacagat tagcaggttt cccaccggat caccaagctt ggagagaaga accctggatt      660

catcatgcac cacaaggttg tggaaattca tcaggagggc cggtcgacat gaatagtagc      720

aattactgct gtgaattgtg ttgtagccct gcttgtaccg ggtgctatac aattacaggt      780

gatacttgta atgaggagac ccagaatctg agcacaatat atctcaggaa atatcaatca      840

aaagttaaga ggcagatatt ttcagactat cagtcagagg ttgacatata taacagaatt      900

cggaatgaat tagggccggg gcccgctccc cagtctatta cagaactatg ttcggaatat      960

cgcaacacac aaatatatac gataaatgac aagatactat catatacgga atcgatggca     1020

ggcaaaagag aaatggttat cattacattt aagagcggcg caacatttca ggtcgaagtc     1080

ccgggcagtc aacatataga ctcccaaaaa aaagccattg aaaggatgaa ggacacatta     1140

agaatcacat atctgaccga gaccaaaatt gataaattat gtgtatggaa taataaaacc     1200

cccaattcaa ttgcggcaat cagtgatccc cgggtaccga gctcgatgaa tagtagcaat     1260

tactgctgtg aattgtgttg tagccctgct tgtaccgggt gctattaata acggccg        1317


<210>  30
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  30
atgaatagta gcaattactg ctgtgaattg tgttgtaatc ctcagtgtac cgggtgctat       60


<210>  31
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  31
atgaatagta gcaattactg ctgtgaattg tgttgtagcc ctgcttgtac cgggtgctat       60


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  32
gaattgtgtt gtagccctgc ttgt                                              24


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  33
acaagcaggg ctacaacaca attc                                              24


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  34
tgttgtaatc ctcagtgtac cggg                                              24


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  35
cccggtacac tgaggattac aa                                                22


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  36

Gly Pro Val Asp 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  37

Gly Pro Gly Pro 
1               


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  38

Gly Gly Pro Val Asp 
1               5   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  39

Asp Pro Arg Val Pro Ser Ser 
1               5           


<210>  40
<211>  1222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  40
atggctagca tgaatagtag caattactgc tgtgaattgt gttgtagccc tgcttgtacc       60

gggtgctatg ggccggggcc caatggcgac aaattatacc gtgctgactc tagaccccca      120

gatgaaataa aacgttccgg aggtcttatg cccagagggc ataatgagta catggctagc      180

gcagtagagg attttttcat tgttccagtt tctggagatc ctgcaattga tcttttgcaa      240

gctgatggca atgctctgcc atcagctgta aagttagctt attctcccgc atcaaaaact      300

aatactttgg tgggtgtttt gactcttgta catacaaacg atgcaactaa aaaaaatgta      360

ctagttaagc ttgtaacacc acagcttaca gatgttctga atccaaccct gcaaattcct      420

gtttctgtgc aggtaacggt ctaccctgtt tctacaacag ccaaagaatt tgaagctgct      480

gctttgggat attctgcatc cggtgtaaat ggcttggtgt caattgtgct tactgtaatt      540

agcgctgcac ctaaaactgc cggtaccgcc ccaactgcag gaaactattc aggagtagta      600

tctcttgtaa tgactttggg agccgatggt tacagattag caggtttccc accggatcac      660

caggcatgga gagaagaacc ctggattcat catgcaccac aaggttgtgg aaattcatca      720

ggagggccgg tcgacatgaa tagtagcaat tactgctgtg aattgtgttg tagccctgct      780

tgtaccgggt gctatacaat tacaggtgat atgttcggaa tatcgcaaca cacaaatata      840

tacgataaat gacaagatac tatcatatac ggaatcgatg gcaggcaaaa gagaaatggt      900

tatcattaca tttaagagcg gcgcaacatt tcaggtcgaa gtcccgggca gtcaacatat      960

agactcccaa aaaaaagcca ttgaaaggat gaaggacaca ttaagaatca catatctgac     1020

cgagaccaaa attgataaat tatgtgtatg gaataataaa acccccaatt caattgcggc     1080

aatcagtgat ccccgggtac cgagctcgat gaatagtagc aattactgct gtgaattgtg     1140

ttgtagccct gcttgtaccg ggtgctatta ataacggccg cactcgagca ccaccaccac     1200

caccactgag atccggctgc ta                                              1222


<210>  41
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1769)..(1770)
<223>  n is a, c, g, or t

<400>  41
nngcattagg aagcagccca gtagtaggtt gaggccgttg agcaccgccg ccgcaaggaa       60

tggtgcatgc aaggagatgg cgcccaacag tcccccggcc acggggcctg ccaccatacc      120

cacgccgaaa caagcgctca tgagcccgaa gtggcgagcc cgatcttccc catcggtgat      180

gtcggcgata taggcgccag caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg      240

tccggcgtag aggatcgaga tctcgatccc gcgaaattaa tacgactcac tataggggaa      300

ttgtgagcgg ataacaattc ccctctagaa ataattttgt ttaactttaa gaaggagata      360

taccatggaa atggctagca tgaatagtag caattactgc tgtgaattgt gttgtagccc      420

tgcttgtacc gggtgctatg ggccggggcc caatggcgac aaattatacc gtgctgactc      480

tagaccccca gatgaaataa aacgttccgg aggtcttatg cccagagggc ataatgagta      540

catggctagc gcagtagagg attttttcat tgttccagtt tctggagatc ctgcaattga      600

tcttttgcaa gctgatggca atgctctgcc atcagctgta aagttagctt attctcccgc      660

atcaaaaact aatactttgg tgggtgtttt gactcttgta catacaaacg atgcaactaa      720

aaaaaatgta ctagttaagc ttgtaacacc acagcttaca gatgttctga atccaaccct      780

gcaaattcct gtttctgtgc aggtaacggt ctaccctgtt tctacaacag ccaaagaatt      840

tgaagctgct gctttgggat attctgcatc cggtgtaaat ggcttggtgt caattgtgct      900

tactgtaatt agcgctgcac ctaaaactgc cggtaccgcc ccaactgcag gaaactattc      960

aggagtagta tctcttgtaa tgactttggg agccgatggt tacagattag caggtttccc     1020

accggatcac caggcatgga gagaagaacc ctggattcat catgcaccac aaggttgtgg     1080

aaattcatca ggagggccgg tcgacatgaa tagtagcaat tactgctgtg aattgtgttg     1140

tagccctgct tgtaccgggt gctatacaat tacaggtgat acttgtaatg aggagaccca     1200

gaatctgagc acaatatatg ccaggaaata tcaatcaaaa gttaagaggc agatattttc     1260

agactatcag tcagaggttg acatatataa cagaattcgg aatgaattag ggccggggcc     1320

cgctccccag tctattacag aactatgttc ggaatatcgc aacacacaaa tatatacgat     1380

aaatgacaag atactatcat atacggaatc gatggcaggc aaaagagaaa tggttatcat     1440

tacatttaag agcggcgcaa catttcaggt cgaagtcccg ggcagtcaac atatagactc     1500

ccaaaaaaaa gccattgaaa ggatgaagga cacattaaga atcacatatc tgaccgagac     1560

caaaattgat aaattatgtg tatggaataa taaaaccccc aattcaattg cggcaatcag     1620

tgatccccgg gtaccgagct cgatgaatag tagcaattac tgctgtgaat tgtgttgtag     1680

ccctgcttgt accgggtgct attaataacg gccgcactcg agcaccacca ccaccaccac     1740

tgagatccgg ctgctaacaa agcccgaann                                      1770


<210>  42
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  42

Met Ala Ser Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Ser 
1               5                   10                  15      


Pro Ala Cys Thr Gly Cys Tyr Gly Pro Gly Pro Asn Gly Asp Lys Leu 
            20                  25                  30          


Tyr Arg Ala Asp Ser Arg Pro Pro Asp Glu Ile Lys Arg Ser Gly Gly 
        35                  40                  45              


Leu Met Pro Arg Gly His Asn Glu Tyr Met Ala Ser Ala Val Glu Asp 
    50                  55                  60                  


Phe Phe Ile Val Pro Val Ser Gly Asp Pro Ala Ile Asp Leu Leu Gln 
65                  70                  75                  80  


Ala Asp Gly Asn Ala Leu Pro Ser Ala Val Lys Leu Ala Tyr Ser Pro 
                85                  90                  95      


Ala Ser Lys Thr Asn Thr Leu Val Gly Val Leu Thr Leu Val His Thr 
            100                 105                 110         


Asn Asp Ala Thr Lys Lys Asn Val Leu Val Lys Leu Val Thr Pro Gln 
        115                 120                 125             


Leu Thr Asp Val Leu Asn Pro Thr Leu Gln Ile Pro Val Ser Val Gln 
    130                 135                 140                 


Val Thr Val Tyr Pro Val Ser Thr Thr Ala Lys Glu Phe Glu Ala Ala 
145                 150                 155                 160 


Ala Leu Gly Tyr Ser Ala Ser Gly Val Asn Gly Leu Val Ser Ile Val 
                165                 170                 175     


Leu Thr Val Ile Ser Ala Ala Pro Lys Thr Ala Gly Thr Ala Pro Thr 
            180                 185                 190         


Ala Gly Asn Tyr Ser Gly Val Val Ser Leu Val Met Thr Leu Gly Ala 
        195                 200                 205             


Asp Gly Tyr Arg Leu Ala Gly Phe Pro Pro Asp His Gln Ala Trp Arg 
    210                 215                 220                 


Glu Glu Pro Trp Ile His His Ala Pro Gln Gly Cys Gly Asn Ser Ser 
225                 230                 235                 240 


Gly Gly Pro Val Asp Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys 
                245                 250                 255     


Cys Ser Pro Ala Cys Thr Gly Cys Tyr Thr Ile Thr Gly Asp Thr Cys 
            260                 265                 270         


Asn Glu Glu Thr Gln Asn Leu Ser Thr Ile Tyr Ala Arg Lys Tyr Gln 
        275                 280                 285             


Ser Lys Val Lys Arg Gln Ile Phe Ser Asp Tyr Gln Ser Glu Val Asp 
    290                 295                 300                 


Ile Tyr Asn Arg Ile Arg Asn Glu Leu Gly Pro Gly Pro Ala Pro Gln 
305                 310                 315                 320 


Ser Ile Thr Glu Leu Cys Ser Glu Tyr Arg Asn Thr Gln Ile Tyr Thr 
                325                 330                 335     


Ile Asn Asp Lys Ile Leu Ser Tyr Thr Glu Ser Met Ala Gly Lys Arg 
            340                 345                 350         


Glu Met Val Ile Ile Thr Phe Lys Ser Gly Ala Thr Phe Gln Val Glu 
        355                 360                 365             


Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala Ile Glu Arg 
    370                 375                 380                 


Met Lys Asp Thr Leu Arg Ile Thr Tyr Leu Thr Glu Thr Lys Ile Asp 
385                 390                 395                 400 


Lys Leu Cys Val Trp Asn Asn Lys Thr Pro Asn Ser Ile Ala Ala Ile 
                405                 410                 415     


Ser Asp Pro Arg Val Pro Ser Ser Met Asn Ser Ser Asn Tyr Cys Cys 
            420                 425                 430         


Glu Leu Cys Cys Ser Pro Ala Cys Thr Gly Cys Tyr 
        435                 440                 


