                         SEQUENCE LISTING

<110>  University of North Carolina at Chapel Hill
       Su, Lishan
 
<120>  DEPLETION OF PLASMACYTOID DENDRITIC CELLS

<130>  5470-680WO

<150>  US 61/916,322
<151>  2013-12-16

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1416
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain coding sequence for monoclonal antibody from 
       hybridoma cell line 15B


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  1
atg gga tgg aac tgg atc ttt att tta atc ctg tca gta act aca ggt         48
Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly           
1               5                   10                  15                

gtc cac tct gag gtc caa ctg cag cag tct gga cct gag ctg gtg aag         96
Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys           
            20                  25                  30                    

cct ggg gct tca gtg aag ata tcc tgc aag gct tct ggt tac tca ttc        144
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe           
        35                  40                  45                        

act gtc tac tac atg cac tgg gtg aag caa agt cct gaa aat agt ctt        192
Thr Val Tyr Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu           
    50                  55                  60                            

gag tgg att gga gag att aat cct agc act ggg ggt act agc tac aac        240
Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn           
65                  70                  75                  80            

cag aag ttc aag ggc aag gcc aca tta act gta gat gaa tcc tcc agc        288
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Ser Ser           
                85                  90                  95                

aca gcc tac atg cag ctc aag agc ctg aca tct gaa gag tct gca gtc        336
Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val           
            100                 105                 110                   

tat tac tgt aca acc ccc tac tat agg tac gag ggg gac tgg tac ttc        384
Tyr Tyr Cys Thr Thr Pro Tyr Tyr Arg Tyr Glu Gly Asp Trp Tyr Phe           
        115                 120                 125                       

gat gtc tgg ggc gca ggg acc acg gtc acc gtc tcc tca gct aaa aca        432
Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr           
    130                 135                 140                           

aca gcc cca tcg gtc tat cca ctg gcc cct gtg tgt gga gat aca act        480
Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr           
145                 150                 155                 160           

ggc tcc tcg gtg act cta gga tgc ctg gtc aag ggt tat ttc cct gag        528
Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu           
                165                 170                 175               

cca gtg acc ttg acc tgg aac tct gga tcc ctg tcc agt ggt gtg cac        576
Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His           
            180                 185                 190                   

acc ttc cca gct gtc ctg cag tct gac ctc tac acc ctc agc agc tca        624
Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser           
        195                 200                 205                       

gtg act gta acc tcg agc acc tgg ccc agc cag tcc atc acc tgc aat        672
Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn           
    210                 215                 220                           

gtg gcc cac ccg gca agc agc acc aag gtg gac aag aaa att gag ccc        720
Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro           
225                 230                 235                 240           

aga ggg ccc aca atc aag ccc tgt cct cca tgc aaa tgc cca gca cct        768
Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro           
                245                 250                 255               

aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct cca aag atc aag        816
Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys           
            260                 265                 270                   

gat gta ctc atg atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg        864
Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val           
        275                 280                 285                       

gat gtg agc gag gat gac cca gat gtc cag atc agc tgg ttt gtg aac        912
Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn           
    290                 295                 300                           

aac gtg gaa gta cac aca gct cag aca caa acc cat aga gag gat tac        960
Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr           
305                 310                 315                 320           

aac agt act ctc cgg gtg gtc agt gcc ctc ccc atc cag cac cag gac       1008
Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp           
                325                 330                 335               

tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc       1056
Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu           
            340                 345                 350                   

cca gcg ccc atc gag aga acc atc tca aaa ccc aaa ggg tca gta aga       1104
Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg           
        355                 360                 365                       

gct cca cag gta tat gtc ttg cct cca cca gaa gaa gag atg act aag       1152
Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys           
    370                 375                 380                           

aaa cag gtc act ctg acc tgc atg gtc aca gac ttc atg cct gaa gac       1200
Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp           
385                 390                 395                 400           

att tac gtg gag tgg acc aac aac ggg aaa aca gag cta aac tac aag       1248
Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys           
                405                 410                 415               

aac act gaa cca gtc ctg gac tct gat ggt tct tac ttc atg tac agc       1296
Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser           
            420                 425                 430                   

aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga aat agc tac tcc       1344
Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser           
        435                 440                 445                       

tgt tca gtg gtc cac gag ggt ctg cac aat cac cac acg act aag agc       1392
Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser           
    450                 455                 460                           

ttc tcc cgg act ccg ggt aaa taa                                       1416
Phe Ser Arg Thr Pro Gly Lys                                               
465                 470                                                   


<210>  2
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Val Tyr Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Pro Tyr Tyr Arg Tyr Glu Gly Asp Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        355                 360                 365             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    370                 375                 380                 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
385                 390                 395                 400 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                405                 410                 415     


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        435                 440                 445             


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    450                 455                 460                 


Phe Ser Arg Thr Pro Gly Lys 
465                 470     


<210>  3
<211>  708
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain coding sequence for monoclonal antibody from 
       hybridoma cell line 15B


<220>
<221>  CDS
<222>  (1)..(705)

<400>  3
atg cat ttt caa gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tcc aga gga caa att gtt ctc acc cag tct cca gca atc         96
Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile           
            20                  25                  30                    

atg tct gca tct cca ggg gag aag gtc acc ata acc tgc agt gcc agc        144
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser           
        35                  40                  45                        

tca agt gta agt tac atg cac tgg ttc cag cag aag cca ggc act tct        192
Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser           
    50                  55                  60                            

ccc aaa ctc tgg att tat agc aca tcc aac ctg gct tct gga gtc cct        240
Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro           
65                  70                  75                  80            

gct cgc ttc agt ggc agt gga tct ggg acc tct tac tct ctc aca atc        288
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile           
                85                  90                  95                

agc cga atg gag gct gaa gat gct gcc act tat tac tgc cac caa agg        336
Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg           
            100                 105                 110                   

agt agt tac cca cgg acg ttc ggt gga ggc acc aag ctg gaa atc aga        384
Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg           
        115                 120                 125                       

cgg gct gat gct gca cca act gta tcc atc ttc cca cca tcc agt gag        432
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu           
    130                 135                 140                           

cag tta aca tct gga ggt gcc tca gtc gtg tgc ttc ttg aac aac ttc        480
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe           
145                 150                 155                 160           

tac ccc aaa gac atc aat gtc aag tgg aag att gat ggc agt gaa cga        528
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg           
                165                 170                 175               

caa aat ggc gtc ctg aac agt tgg act gat cag gac agc aaa gac agc        576
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc atg agc agc acc ctc acg ttg acc aag gac gag tat gaa        624
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu           
        195                 200                 205                       

cga cat aac agc tat acc tgt gag gcc act cac aag aca tca act tca        672
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser           
    210                 215                 220                           

ccc att gtc aag agc ttc aac agg aat gag tgt tag                        708
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys                               
225                 230                 235                               


<210>  4
<211>  235
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  5
<211>  1404
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain coding sequence for monoclonal antibody from 
       hybridoma cell line 12B


<220>
<221>  CDS
<222>  (1)..(1401)

<400>  5
atg aac ttc ggg ttc agc ttg att ttc ctt gtc ctt gtt tta aaa ggt         48
Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly           
1               5                   10                  15                

gtc cag tgt gaa gtg aag ctg gtg gag tct ggg gga ggc tta gtg aag         96
Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys           
            20                  25                  30                    

cct gga ggg tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc        144
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
        35                  40                  45                        

agt acc atg tct tgg gtt cgc cag act cca gag aag agg ctg gag tgg        192
Ser Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp           
    50                  55                  60                            

gtc gca tcc att agt agt ggt ggt agt act tac tat cca gac agt gtg        240
Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val           
65                  70                  75                  80            

aag ggc cga ttc acc atc tcc aga gat aat gcc agg aac atc ctg tac        288
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr           
                85                  90                  95                

ctg caa atg agc agt ctg agg tct gag gac acg gcc atg tat tac tgt        336
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys           
            100                 105                 110                   

gca aga ccc tct tat gat ggt tac tcc tcc tgg ttt gct tac tgg ggc        384
Ala Arg Pro Ser Tyr Asp Gly Tyr Ser Ser Trp Phe Ala Tyr Trp Gly           
        115                 120                 125                       

caa ggg act ctg gtc act gtc tct gca gcc aaa aca aca gcc cca tcg        432
Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser           
    130                 135                 140                           

gtc tat cca ctg gcc cct gtg tgt gga gat aca act ggc tcc tcg gtg        480
Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val           
145                 150                 155                 160           

act cta gga tgc ctg gtc aag ggt tat ttc cct gag cca gtg acc ttg        528
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu           
                165                 170                 175               

acc tgg aac tct gga tcc ctg tcc agt ggt gtg cac acc ttc cca gct        576
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala           
            180                 185                 190                   

gtc ctg cag tct gac ctc tac acc ctc agc agc tca gtg act gta acc        624
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr           
        195                 200                 205                       

tcg agc acc tgg ccc agc cag tcc atc acc tgc aat gtg gcc cac ccg        672
Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro           
    210                 215                 220                           

gca agc agc acc aag gtg gac aag aaa att gag ccc aga ggg ccc aca        720
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr           
225                 230                 235                 240           

atc aag ccc tgt cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt        768
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly           
                245                 250                 255               

gga cca tcc gtc ttc atc ttc cct cca aag atc aag gat gta ctc atg        816
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met           
            260                 265                 270                   

atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg gat gtg agc gag        864
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu           
        275                 280                 285                       

gat gac cca gat gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta        912
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val           
    290                 295                 300                           

cac aca gct cag aca caa acc cat aga gag gat tac aac agt act ctc        960
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu           
305                 310                 315                 320           

cgg gtg gtc agt gcc ctc ccc atc cag cac cag gac tgg atg agt ggc       1008
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly           
                325                 330                 335               

aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc       1056
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile           
            340                 345                 350                   

gag aga acc atc tca aaa ccc aaa ggg tca gta aga gct cca cag gta       1104
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val           
        355                 360                 365                       

tat gtc ttg cct cca cca gaa gaa gag atg act aag aaa cag gtc act       1152
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr           
    370                 375                 380                           

ctg acc tgc atg gtc aca gac ttc atg cct gaa gac att tac gtg gag       1200
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu           
385                 390                 395                 400           

tgg acc aac aac ggg aaa aca gag cta aac tac aag aac act gaa cca       1248
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro           
                405                 410                 415               

gtc ctg gac tct gat ggt tct tac ttc atg tac agc aag ctg aga gtg       1296
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val           
            420                 425                 430                   

gaa aag aag aac tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc       1344
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val           
        435                 440                 445                       

cac gag ggt ctg cac aat cac cac acg act aag agc ttc tcc cgg act       1392
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr           
    450                 455                 460                           

ccg ggt aaa taa                                                       1404
Pro Gly Lys                                                               
465                                                                       


<210>  6
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp 
    50                  55                  60                  


Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
65                  70                  75                  80  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr 
                85                  90                  95      


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Pro Ser Tyr Asp Gly Tyr Ser Ser Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  7
<211>  717
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain coding sequence for monoclonal antibody from 
       hybridoma cell line 12B


<220>
<221>  CDS
<222>  (1)..(714)

<400>  7
atg gag aca gac aca atc ctg cta tgg gtg ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggc tcc act ggt gac att gtg ctg acc caa tct cca gct tct ttg gct         96
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala           
            20                  25                  30                    

gtg tct cta ggg cag agg gcc acc atc tcc tgc aag gcc agc caa agt        144
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser           
        35                  40                  45                        

gtt gat tat gat ggt gat ggt ttt atg aac tgg tac caa cag aaa cca        192
Val Asp Tyr Asp Gly Asp Gly Phe Met Asn Trp Tyr Gln Gln Lys Pro           
    50                  55                  60                            

gga cag cca ccc aaa ctc ctc atc tat act gca tcc aat cta gaa tct        240
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Thr Ala Ser Asn Leu Glu Ser           
65                  70                  75                  80            

ggg atc cca gcc agg ttt agt ggc agt ggg tct ggg aca gac ttc acc        288
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr           
                85                  90                  95                

ctc aac atc cat cct gtg gag gag gag gat gct gca acc tat tac tgt        336
Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys           
            100                 105                 110                   

cag caa agt aat gag gat ccg tgg acg ttc ggt gga ggc acc aag ctg        384
Gln Gln Ser Asn Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu           
        115                 120                 125                       

gaa atc aaa cgg gct gat gct gca cca act gta tcc atc ttc cca cca        432
Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro           
    130                 135                 140                           

tcc agt gag cag tta aca tct gga ggt gcc tca gtc gtg tgc ttc ttg        480
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu           
145                 150                 155                 160           

aac aac ttc tac ccc aaa gac atc aat gtc aag tgg aag att gat ggc        528
Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly           
                165                 170                 175               

agt gaa cga caa aat ggc gtc ctg aac agt tgg act gat cag gac agc        576
Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser           
            180                 185                 190                   

aaa gac agc acc tac agc atg agc agc acc ctc acg ttg acc aag gac        624
Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp           
        195                 200                 205                       

gag tat gaa cga cat aac agc tat acc tgt gag gcc act cac aag aca        672
Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr           
    210                 215                 220                           

tca act tca ccc att gtc aag agc ttc aac agg aat gag tgt tag            717
Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys                   
225                 230                 235                               


<210>  8
<211>  238
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Asp Gly Phe Met Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Thr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Asn Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  9
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope sequence bound by monoclonal antibody from hybridoma cell
       line 15B

<400>  9

Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu Ser Asp 
1               5                   10                  15      


Pro Gly Gly Arg 
            20  


