                         SEQUENCE LISTING

<110>  Exploit Technologies Pte Ltd
 
<120>  Differentiation Therapy with CD137 ligand agonists

<130>  9869SG2875

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  2
<211>  1928
<212>  DNA
<213>  Homo sapiens

<400>  2
ggagtggaaa gttctccggc agccctgaga tctcaagagt gacatttgtg agaccagcta       60

atttgattaa aattctcttg gaatcagctt tgctagtatc atacctgtgc cagatttcat      120

catgggaaac agctgttaca acatagtagc cactctgttg ctggtcctca actttgagag      180

gacaagatca ttgcaggatc cttgtagtaa ctgcccagct ggtacattct gtgataataa      240

caggaatcag atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag      300

gacctgtgac atatgcaggc agtgtaaagg tgttttcagg accaggaagg agtgttcctc      360

caccagcaat gcagagtgtg actgcactcc agggtttcac tgcctggggg caggatgcag      420

catgtgtgaa caggattgta aacaaggtca agaactgaca aaaaaaggtt gtaaagactg      480

ttgctttggg acatttaacg atcagaaacg tggcatctgt cgaccctgga caaactgttc      540

tttggatgga aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgtggacc      600

atctccagcc gacctctctc cgggagcatc ctctgtgacc ccgcctgccc ctgcgagaga      660

gccaggacac tctccgcaga tcatctcctt ctttcttgcg ctgacgtcga ctgcgttgct      720

cttcctgctg ttcttcctca cgctccgttt ctctgttgtt aaacggggca gaaagaaact      780

cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg      840

ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgtgaa atggaagtca      900

atagggctgt tgggactttc ttgaaaagaa gcaaggaaat atgagtcatc cgctatcaca      960

gctttcaaaa gcaagaacac catcctacat aatacccagg attcccccaa cacacgttct     1020

tttctaaatg ccaatgagtt ggcctttaaa aatgcaccac tttttttttt tttttgacag     1080

ggtctcactc tgtcacccag gctggagtgc agtggcacca ccatggctct ctgcagcctt     1140

gacctctggg agctcaagtg atcctcctgc ctcagtctcc tgagtagctg gaactacaag     1200

gaagggccac cacacctgac taactttttt gttttttgtt tggtaaagat ggcatttcac     1260

catgttgtac aggctggtct caaactccta ggttcacttt ggcctcccaa agtgctggga     1320

ttacagacat gaactgccag gcccggccaa aataatgcac cacttttaac agaacagaca     1380

gatgaggaca gagctggtga taaaaaaaaa aaaaaaaaag cattttctag ataccactta     1440

acaggtttga gctagttttt ttgaaatcca aagaaaatta tagtttaaat tcaattacat     1500

agtccagtgg tccaactata attataatca aaatcaatgc aggtttgttt tttggtgcta     1560

atatgacata tgacaataag ccacgaggtg cagtaagtac ccgactaaag tttccgtggg     1620

ttctgtcatg taacacgaca tgctccaccg tcagggggga gtatgagcag agtgcctgag     1680

tttagggtca aggacaaaaa acctcaggcc tggaggaagt tttggaaaga gttcaagtgt     1740

ctgtatatcc tatggtcttc tccatcctca caccttctgc ctttgtcctg ctccctttta     1800

agccaggtta cattctaaaa attcttaact tttaacataa tattttatac caaagccaat     1860

aaatgaactg catatgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaa                                                              1928


<210>  3
<211>  681
<212>  DNA
<213>  artificial sequence

<220>
<223>  hIgG1-Fc region

<400>  3
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


