                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Novel eukaryotic cells and methods for recombinantly expressing a
        product of interest

<130>  PAT056009-WO-PCT

<150>  US 61/919340
<151>  2013-12-20

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Gly Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Glu Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  2
<211>  221
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Met Lys Ser Ser Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Glu Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Ser Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Ser Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Ala Pro Ala Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  3
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  3

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Met Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Glu Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Ser Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Ser Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Ala Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  4
<211>  221
<212>  PRT
<213>  Cricetulus griseus

<400>  4

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Ser His Ser 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Met Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Ser Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Ser Lys Lys Ala Ala Pro Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Ala Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  5
<211>  222
<212>  PRT
<213>  Gallus gallus

<400>  5

Met Phe Gly Phe Arg Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Asn Cys Phe Gly Leu His Glu Ala Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Met Lys 
                85                  90                  95      


Thr Leu Ser Gly Ser Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Glu Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ser Ala Gly Ser Ser Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Val Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ser Ala Thr Glu Lys Pro Glu Gln 
        195                 200                 205             


Glu Gly Pro Gln Ser Pro Ala Ile Ser Thr Gln Glu Glu Trp 
    210                 215                 220         


<210>  6
<211>  221
<212>  PRT
<213>  Pan troglodytes

<400>  6

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Gly Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Glu Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  7
<211>  221
<212>  PRT
<213>  Pongo abelii

<400>  7

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Arg Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Gly Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Glu Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  8
<211>  221
<212>  PRT
<213>  Bos taurus

<400>  8

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Gly Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Glu Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  9
<211>  1236
<212>  DNA
<213>  Cricetulus griseus

<400>  9
ctcagaagaa aagatgtttg gttttcacaa gccaaagatg taccgaagta tagagggctg       60

ctgtatctgc agagccaagt cctccagctc tcggttcacg gacagtaaac gttatgaaaa      120

ggacttccag agctgttttg ggttgcacga gactcgctca ggagatatct gcaatgcctg      180

tgtgctgctt gtgaaaagat ggaagaagtt gccagcagga tcaaaaaaaa actggaatca      240

tgtgtcacac tcaagggcag gacccagtct aaagacaaca ttgaaaccaa agaaagtgaa      300

aactctatct ggaaacagga tgaaaagcaa ccagatcagt aaactgcaga aggagtttaa      360

acgccacaac tctgatgctc acagtaccac ctcaagtgcc tcgccagccc agtctccctg      420

ctacagtaac cagtcagatg atggctcaga cacagagatg gcttccagct ctaacagaac      480

tccagttttt tccttcttag atcttaccta ctggaaaaga cagaaaatat gttgtgggat      540

catctataag ggccgttttg gggaagtcct catcgacacg catctcttca agccttgctg      600

cagcagtaag aaggcagctc ctgagaagcc tgaggaacag ggaccagcgc ctctgcccat      660

ctctactcag gagtggtgac tgaggttcat gcagaaggga acaaagagca atttaaactt      720

tgaaaagacc acaaagcaac agactgaccc tcctattttt aacttggata cctgctattc      780

tgccaaaaga cattttctag aatagttttt aatgggttac ccatcccccc atccaacaaa      840

ctcggaagcc agttctagct tactgcaaga agagagtgta cataatattt aatatgctga      900

gtatttcata ggaaggctga atgctgctgt aaagtgctct ttaagtcttt tttttttttt      960

aatcccctct aatgaatgag attagggggg tttcagggga cagagatggg atttgttgtg     1020

tgataaacca tatgtagttt agtctttctg tggagaggca gtggttgggg cattttaaat     1080

ggctggctac acttgttttc ccctcatggt aatttgtcat aactcagtag cacgacctgc     1140

ccctagaagt agttaaagat ttttaaatgc taaggcgttg ccaaggttct gatgattcag     1200

acctgtacta ctgattatta agcaggacag actgag                               1236


<210>  10
<211>  1547
<212>  PRT
<213>  Cricetulus griseus

<400>  10

Met Asn Trp Asn Ala Lys Pro Glu Asn Ala Ala Pro Asn Pro Pro Tyr 
1               5                   10                  15      


Ser Lys Ser Gln Ser Ser Leu Leu Gln Gln Phe Leu Met Pro Ser Thr 
            20                  25                  30          


Thr Ser Gln Ser Ser Phe Ser Cys Leu Pro His Asn Gln Glu Ala Cys 
        35                  40                  45              


Ile Tyr Pro Thr Asn Ser Asn Ser Val Ser Gln Pro Leu Leu Asn Val 
    50                  55                  60                  


Arg Ser Phe Ile Asn Pro Pro Ile Ser Val Ser Asn Val His Asn Arg 
65                  70                  75                  80  


Thr Val Val Ala Ser Gln Thr Ser Val Glu Arg Val Thr Tyr Thr Asn 
                85                  90                  95      


Val Lys Gly Ala Gln Gln Pro Asn His Asn Leu Gln Thr Val Ser Ser 
            100                 105                 110         


Gly Val Val Gln Asn Ala Trp Met Asn Ser Thr Met Arg Asn Phe Met 
        115                 120                 125             


Pro Ser Leu Thr Glu Ala Thr Ile Ser His Lys Pro Asp Gly Gly Pro 
    130                 135                 140                 


Ser Met Pro Tyr Met His Ala Pro Gln Ser His Leu Val Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Val Gln Leu Gln Met Thr Pro Ser Asn Ser Val Arg Gly 
                165                 170                 175     


Pro Val Thr Tyr Gln Gly Asn Tyr Gln Gly Asn Pro Gly Leu Asn His 
            180                 185                 190         


Ser Met Ala Gly Glu Leu Gly Trp Val Gln Cys Ala Ser Ser Glu Leu 
        195                 200                 205             


Thr Tyr Pro Asp Tyr Arg Pro Pro Pro Lys Gln Tyr Pro Tyr Leu Pro 
    210                 215                 220                 


Gln Ser Phe Val Gln Asp Thr Ser Val Gln Lys Gln Asn Phe Val Ser 
225                 230                 235                 240 


Ser Thr Ser Leu Gln Val Lys Asn Asn Gln Leu Pro Pro Ser Thr Gln 
                245                 250                 255     


Thr Leu Pro Ser Lys Arg Pro Val Pro Val Ser Ser Tyr Gln Tyr Ala 
            260                 265                 270         


Ala Glu Thr Ser Lys Arg Leu Pro Pro Pro Pro Tyr Ser Cys Arg Tyr 
        275                 280                 285             


Gly Ser Gln His Val Gln Asn Ser Gln Ser Val Ser Arg His Leu Pro 
    290                 295                 300                 


Val Glu Val Pro Gln Ser Ser Glu Met His Ser Ser Glu Lys Lys Lys 
305                 310                 315                 320 


Asp Ala Tyr Lys Val Phe Gln Gln Gln Trp Gln Ser Thr Ser Lys Asn 
                325                 330                 335     


Val Ser Thr Ile Gly Lys Phe Cys Glu Leu Lys Ile Asn Thr Lys Gln 
            340                 345                 350         


Ser Tyr Asn Asp Ser Ala Gly Ser Ser Gly Asp Gly Val His Thr Leu 
        355                 360                 365             


Val Gln Asn Asn Gln Glu Glu Arg Lys Tyr Ser Tyr Asn Pro Ser Thr 
    370                 375                 380                 


Asn Gln Ile Leu Asp Thr Asn Val Thr Lys Glu Lys Leu Val Arg Asp 
385                 390                 395                 400 


Ile Lys Ser Leu Val Glu Ile Lys Lys Lys Phe Ser Glu Leu Ala Arg 
                405                 410                 415     


Lys Ile Lys Ile Asn Lys Lys Leu Leu Met Ala Ala Gly Cys Ser Lys 
            420                 425                 430         


Thr Ala Asn Thr Ser Tyr Thr Glu Pro Thr Arg His Ser Glu Phe Ser 
        435                 440                 445             


Ala Lys Glu Met Ser Ala Lys Arg Asp Asn Gln Cys Ser Met Glu Leu 
    450                 455                 460                 


Leu Ala Thr Cys Leu Ser Leu Trp Lys Asn Gln Pro Pro Lys Thr Thr 
465                 470                 475                 480 


Glu Glu Asn Val Ser Lys Pro Leu Glu Glu Lys Gln Tyr Asn Ala Ser 
                485                 490                 495     


Arg Thr Ser Thr Thr Ala Val Gly Pro Ser Asn Pro Met Asn Glu Val 
            500                 505                 510         


His Val Lys Asn Phe Cys Ser Gly Val Arg Asn Ser Gln Lys Ile Thr 
        515                 520                 525             


Thr Ser Ser Gln Thr Val Leu Ser Val Leu Thr Pro Val Tyr Asp Ser 
    530                 535                 540                 


Ser Asp Val Ala Val Gly Lys Gly Thr Glu Leu Gln Ile Ala Val Val 
545                 550                 555                 560 


Ser Pro Leu Ile Leu Ser Asp Val Ser Thr Val Pro Gly Lys Glu Leu 
                565                 570                 575     


Ala Pro Glu Val Val Ser Glu Thr Val Tyr Pro Val Val Lys Glu Gly 
            580                 585                 590         


Ser Val Cys Ser Leu Gln Asn Gln Gln Ala Glu Asn Ala Thr Val Thr 
        595                 600                 605             


Ala Gly Leu Pro Phe Asp Val Ile Arg Ala Val Ala Ser Ala Thr Val 
    610                 615                 620                 


Ser Ala Glu Leu Ser Leu Pro Gly His Lys Glu Lys Gln His Lys Pro 
625                 630                 635                 640 


Thr Gln Ser Asp Leu Asp Ile Ala Asp Gly Ser Leu Gly Lys His Ser 
                645                 650                 655     


Pro Gln Gly Ala Glu Ala Leu Pro Asn Pro Arg Asp Ser Thr Ile Val 
            660                 665                 670         


Ser Gly Pro Ile Leu Gln Ile Glu Ser Ile Cys Ser Leu Ala Glu Gly 
        675                 680                 685             


Asp Val Ser Tyr Asn Ser Gln Ile Ala Glu Ile Phe Asn Ser Val Gln 
    690                 695                 700                 


Asn Glu Pro Gln Lys Pro Ser Pro Asp Gln Gln Val Ile Asn Ser Gln 
705                 710                 715                 720 


Gln Glu Glu Gln Val Asp Lys Val Ala Glu Asn Lys Asp Leu Ser Phe 
                725                 730                 735     


Leu Lys Asp Lys Cys Met Gln Cys Thr Asp Val Pro His Glu Val Thr 
            740                 745                 750         


Glu Gln Pro Glu Pro Leu Gln Pro Leu Glu Thr Thr Ser Asp Glu Tyr 
        755                 760                 765             


Val Glu Ala Asn Gly Glu Ile Leu Glu Glu Ser Ser Lys Glu Asn Pro 
    770                 775                 780                 


Gly Glu Lys Glu Met Thr Lys Asp Ile Leu Cys Ser Pro Ala Ala Val 
785                 790                 795                 800 


Gln Gln Asp Pro Gln Pro Gln Glu Ile Asp Thr Ala Ser Ser Lys Ser 
                805                 810                 815     


Gly His Ser Phe Ser Thr Val Asn Glu Ile Asn Asp Glu Asn Glu Pro 
            820                 825                 830         


Val Ser Tyr Leu His Asp Gln Leu Leu Glu Leu Leu Lys Glu Phe Pro 
        835                 840                 845             


Tyr Gly Ile Glu Thr Ile Ala Arg Pro Glu Val Tyr Val Gly Gln Gln 
    850                 855                 860                 


Lys Thr His Glu Ile Leu Glu Asn Gln Thr Gly Ser Lys Thr Gly Asn 
865                 870                 875                 880 


Val Ser Gly Asp Asn Thr Asp Gln Ile Lys Ile Thr Val Leu Asn Ser 
                885                 890                 895     


Glu Gln Ile Lys Glu Leu Phe Pro Glu Glu Asp Gln Pro Cys Asp Val 
            900                 905                 910         


Asp Lys Leu Ala Glu Pro Glu Asn Thr Lys Ile Ile Ala Glu Val Lys 
        915                 920                 925             


Ser Leu Cys Asp Ser Gln Val Pro Arg Glu Glu Ser His Asn Pro Gly 
    930                 935                 940                 


Met Leu Asp Leu Glu Lys Asp Lys Ile His Cys Cys Ala Leu Gly Trp 
945                 950                 955                 960 


Leu Ser Met Val Tyr Glu Gly Val Pro Gln Cys Gln Cys Ser Ser Met 
                965                 970                 975     


Glu Glu Lys Glu Lys Asp Gln Cys Ser Leu Glu Ile Ser Asn Cys Lys 
            980                 985                 990         


Gln Gly Glu Gln Ala Cys Asn Ser  Gly Ile Thr Ile Phe  Glu Ile Asn 
        995                 1000                 1005             


Pro Ile  Ser Asn Asn Ser Lys  Ser Pro Leu Ile Gln  Glu Ser Glu 
    1010                 1015                 1020             


Lys Gly  His Phe Ser Asp Ile  His Gly Glu Lys Ile  Lys Thr Ser 
    1025                 1030                 1035             


Glu Thr  Lys Asn Ser Ser Ser  Pro Arg Val Glu Gln  Glu Leu Thr 
    1040                 1045                 1050             


Gly His  Phe Ser Met Lys Cys  Tyr Gln Lys Asp Lys  Ser Thr Thr 
    1055                 1060                 1065             


Lys Gln  Asp Ser Ser Leu Lys  Thr Glu Gln Lys Ile  Lys Asn Leu 
    1070                 1075                 1080             


Ser Ser  Lys Cys Asp Lys Pro  Asn Pro Leu Lys Ser  Ser Lys Ile 
    1085                 1090                 1095             


Pro Thr  Pro Glu Thr Phe Asn  Val Val Thr Ser Asn  Ser Asp Lys 
    1100                 1105                 1110             


Asn Met  Pro Ala Phe Ser Lys  Gln Asp Ser Gln Gly  Ser Leu Gln 
    1115                 1120                 1125             


Lys Lys  His Leu Phe Gln Asp  Ser Asp Pro Val Lys  Gly His Val 
    1130                 1135                 1140             


Trp Leu  Leu Pro Asn Lys Asp  Pro Arg Arg Arg Asn  Thr Phe Leu 
    1145                 1150                 1155             


Val Gln  Ser Val Ser Pro Glu  Lys Lys Lys Leu Lys  Phe Lys Ser 
    1160                 1165                 1170             


Gly Ser  Ser Lys Leu Lys Tyr  Phe Glu Lys Arg Lys  Met Asp His 
    1175                 1180                 1185             


Leu Leu  Ile Ser Asp Val Glu  Ile Lys Lys Lys Lys  Tyr Glu Lys 
    1190                 1195                 1200             


Gln Glu  Gln Asn Lys Asn Ala  Gly Gly Thr Leu Lys  Leu Cys Ser 
    1205                 1210                 1215             


Thr Leu  Thr Glu Pro Asn Glu  Arg Ala Cys Ala Lys  Glu Lys Ile 
    1220                 1225                 1230             


Val Thr  Asn Ser Glu Pro Ser  Asp Ser Lys Gly Ser  Ser Ser Lys 
    1235                 1240                 1245             


Ser Thr  Arg Val Ile Thr Val  Gln Glu Tyr Leu Gln  Arg Lys Lys 
    1250                 1255                 1260             


Asp Lys  His Val Ile Gly Asn  Asn Ala Ser Lys Asn  Ile Cys Val 
    1265                 1270                 1275             


Glu Asn  Val Pro Cys Asp Ser  Glu Pro Met Lys Ser  Ser Lys His 
    1280                 1285                 1290             


Ser Ala  Ser Pro Ser Leu Gly  Lys Leu Ile Glu Gly  Gln Gly Val 
    1295                 1300                 1305             


Ser Ala  Glu Thr Leu Lys Glu  Val Glu His Asn Ser  Thr Ser His 
    1310                 1315                 1320             


Gly Lys  Asn Leu Lys Thr His  Arg Ser Glu Glu Thr  Arg Pro Tyr 
    1325                 1330                 1335             


Ser Val  Ser Asn Ser Lys Glu  Lys Phe Tyr Arg Thr  His Pro Asp 
    1340                 1345                 1350             


Lys Ser  Tyr Ile Asp Lys Ala  Lys Leu Glu Arg Leu  Thr Ser Met 
    1355                 1360                 1365             


Ser Ser  Lys Ser Ser Gln Leu  Gln Val Lys Glu Lys  Arg Lys Gln 
    1370                 1375                 1380             


Tyr Leu  Asn Arg Val Ala Phe  Lys Cys Thr Glu Gln  Glu Ser Ile 
    1385                 1390                 1395             


Cys Leu  Thr Lys Leu Asp Ser  Ala Ser Lys Lys Leu  Ser Lys Glu 
    1400                 1405                 1410             


Lys Glu  Lys Ser Thr Ala Cys  Ala Pro Met Thr Lys  Asp Tyr Thr 
    1415                 1420                 1425             


His Lys  Pro Met Leu Glu Phe  Lys Leu Cys Pro Asp  Val Leu Leu 
    1430                 1435                 1440             


Lys Asn  Thr Ser Ser Ile Asp  Lys Gly Asp Asp Pro  Arg Pro Gly 
    1445                 1450                 1455             


Pro Glu  Lys Glu Arg Ala Pro  Val Gln Val Ser Gly  Ile Lys Thr 
    1460                 1465                 1470             


Thr Lys  Glu Asp Trp Leu Lys  Cys Ile Pro Thr Arg  Thr Lys Met 
    1475                 1480                 1485             


Pro Glu  Ser Ser Glu Gln Thr  Asp Arg Ala Asp Ser  Arg Leu Ser 
    1490                 1495                 1500             


Lys Arg  Ser Phe Ser Ala Asp  Glu Phe Glu Thr Leu  Gln Asn Pro 
    1505                 1510                 1515             


Val Lys  Asp Ser Asn Val Met  Phe Arg Thr Phe Lys  Lys Met Tyr 
    1520                 1525                 1530             


Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser Ser Pro  Val Lys 
    1535                 1540                 1545         


<210>  11
<211>  1515
<212>  PRT
<213>  Cricetinae gen. sp.


<220>
<221>  UNSURE
<222>  (879)..(879)

<400>  11

Met Asn Trp Asn Ala Lys Pro Glu Asn Ala Ala Pro Asn Pro Pro Tyr 
1               5                   10                  15      


Ser Lys Ser Gln Ser Ser Leu Leu Gln Gln Phe Leu Met Pro Ser Thr 
            20                  25                  30          


Thr Ser Gln Ser Ser Phe Ser Cys Leu Pro His Asn Gln Glu Ala Cys 
        35                  40                  45              


Ile Tyr Pro Thr Asn Ser Asn Ser Val Ser Gln Pro Leu Leu Asn Val 
    50                  55                  60                  


Arg Ser Phe Ile Asn Pro Pro Ile Ser Val Ser Asn Val His Asn Arg 
65                  70                  75                  80  


Thr Val Val Ala Ser Gln Thr Ser Val Glu Arg Val Thr Tyr Thr Asn 
                85                  90                  95      


Val Lys Gly Ala Gln Gln Pro Asn His Asn Leu Gln Thr Val Ser Ser 
            100                 105                 110         


Gly Val Val Gln Asn Ala Trp Met Asn Ser Thr Met Arg Asn Phe Met 
        115                 120                 125             


Pro Ser Leu Thr Glu Ala Thr Ile Ser His Lys Pro Asp Gly Gly Pro 
    130                 135                 140                 


Ser Met Pro Tyr Met His Ala Pro Gln Ser His Leu Val Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Val Gln Leu Gln Met Thr Pro Ser Asn Ser Val Arg Gly 
                165                 170                 175     


Pro Val Thr Tyr Gln Gly Asn Tyr Gln Gly Asn Pro Gly Leu Asn His 
            180                 185                 190         


Ser Met Ala Gly Glu Leu Gly Trp Val Gln Cys Ala Ser Ser Glu Leu 
        195                 200                 205             


Thr Tyr Pro Asp Tyr Arg Pro Pro Pro Lys Gln Tyr Pro Tyr Leu Pro 
    210                 215                 220                 


Gln Ser Phe Val Gln Asp Thr Ser Val Gln Lys Gln Asn Phe Val Ser 
225                 230                 235                 240 


Ser Thr Ser Leu Gln Val Lys Asn Asn Gln Leu Pro Pro Ser Thr Gln 
                245                 250                 255     


Thr Leu Pro Ser Lys Arg Pro Val Pro Val Ser Ser Tyr Gln Tyr Ala 
            260                 265                 270         


Ala Glu Thr Ser Lys Arg Leu Pro Pro Pro Pro Tyr Ser Cys Arg Tyr 
        275                 280                 285             


Gly Ser Gln His Val Gln Asn Ser Gln Ser Val Ser Arg His Leu Pro 
    290                 295                 300                 


Val Glu Val Pro Gln Ser Ser Glu Met His Ser Ser Glu Lys Lys Lys 
305                 310                 315                 320 


Asp Ala Tyr Lys Val Phe Gln Gln Gln Trp Gln Ser Thr Ser Lys Asn 
                325                 330                 335     


Val Ser Thr Ile Gly Lys Phe Cys Glu Leu Lys Ile Asn Thr Lys Gln 
            340                 345                 350         


Ser Tyr Asn Asp Ser Ala Gly Ser Ser Gly Asp Gly Val His Thr Leu 
        355                 360                 365             


Val Gln Asn Asn Gln Glu Glu Arg Lys Tyr Ser Tyr Asn Pro Ser Thr 
    370                 375                 380                 


Asn Gln Ile Leu Asp Thr Asn Val Thr Lys Glu Lys Leu Val Arg Asp 
385                 390                 395                 400 


Ile Lys Ser Leu Val Glu Ile Ser Trp Ala Met Val Ala His Ser Glu 
                405                 410                 415     


Phe Ser Ala Lys Glu Met Ser Ala Lys Arg Asp Asn Gln Cys Ser Met 
            420                 425                 430         


Glu Leu Leu Ala Thr Cys Leu Ser Leu Trp Lys Asn Gln Pro Pro Lys 
        435                 440                 445             


Thr Thr Glu Glu Asn Val Ser Lys Pro Leu Glu Glu Lys Gln Tyr Asn 
    450                 455                 460                 


Ala Ser Arg Thr Ser Thr Thr Ala Val Gly Pro Ser Asn Pro Met Asn 
465                 470                 475                 480 


Glu Val His Val Lys Asn Phe Cys Ser Gly Val Arg Asn Ser Gln Lys 
                485                 490                 495     


Ile Thr Thr Ser Ser Gln Thr Val Leu Ser Val Leu Thr Pro Val Tyr 
            500                 505                 510         


Asp Ser Ser Asp Val Ala Val Gly Lys Gly Thr Glu Leu Gln Ile Ala 
        515                 520                 525             


Val Val Ser Pro Leu Ile Leu Ser Asp Val Ser Thr Val Pro Gly Lys 
    530                 535                 540                 


Glu Leu Ala Pro Glu Val Val Ser Glu Thr Val Tyr Pro Val Val Lys 
545                 550                 555                 560 


Glu Gly Ser Val Cys Ser Leu Gln Asn Gln Gln Ala Glu Asn Ala Thr 
                565                 570                 575     


Val Thr Ala Gly Leu Pro Phe Asp Val Ile Arg Ala Val Ala Ser Ala 
            580                 585                 590         


Thr Val Ser Ala Glu Leu Ser Leu Pro Gly His Lys Glu Lys Gln His 
        595                 600                 605             


Lys Pro Thr Gln Thr Asp Leu Asp Thr Ala Asp Gly Ser Leu Gly Lys 
    610                 615                 620                 


His Ser Pro Gln Gly Ala Glu Ala Leu Pro Asn Pro Arg Asp Ser Thr 
625                 630                 635                 640 


Ile Val Ser Gly Pro Ile Leu Gln Ile Glu Ser Ile Cys Ser Leu Ala 
                645                 650                 655     


Glu Gly Asp Val Ser Tyr Asn Ser Gln Ile Ala Glu Ile Phe Asn Ser 
            660                 665                 670         


Val Gln Asn Glu Pro Gln Lys Pro Ser Pro Asp Gln Gln Val Ile Asn 
        675                 680                 685             


Ser Gln Gln Glu Glu Gln Val Asp Lys Val Ala Glu Asn Lys Asp Leu 
    690                 695                 700                 


Ser Phe Leu Lys Asp Lys Cys Met Gln Cys Thr Asp Val Pro His Glu 
705                 710                 715                 720 


Val Thr Glu Gln Pro Glu Pro Leu Gln Pro Leu Glu Thr Thr Ser Asp 
                725                 730                 735     


Glu Tyr Val Glu Ala Asn Gly Glu Ile Leu Glu Glu Ser Ser Lys Glu 
            740                 745                 750         


Asn Pro Gly Glu Lys Glu Met Thr Lys Asp Ile Leu Cys Ser Pro Ala 
        755                 760                 765             


Ala Val Gln Gln Asp Pro Gln Pro Gln Glu Ile Asp Thr Ala Ser Ser 
    770                 775                 780                 


Lys Ser Gly His Ser Phe Ser Thr Val Asn Glu Ile Asn Asp Glu Asn 
785                 790                 795                 800 


Glu Pro Val Ser Tyr Leu His Asp Gln Leu Leu Glu Leu Leu Lys Glu 
                805                 810                 815     


Phe Pro Tyr Gly Ile Glu Thr Ile Ala Arg Pro Glu Val Tyr Val Gly 
            820                 825                 830         


Gln Gln Lys Thr His Glu Ile Leu Glu Asn Gln Thr Gly Ser Lys Thr 
        835                 840                 845             


Gly Asn Val Ser Gly Asp Asn Thr Asp Gln Ile Lys Ile Thr Val Leu 
    850                 855                 860                 


Asn Ser Glu Gln Ile Lys Glu Leu Phe Pro Glu Glu Asp Gln Xaa Val 
865                 870                 875                 880 


Asp Lys Leu Ala Glu Pro Glu Asn Thr Lys Ile Ile Ala Glu Val Lys 
                885                 890                 895     


Ser Leu Cys Asp Ser Gln Val Pro Arg Glu Glu Ser His Asn Pro Gly 
            900                 905                 910         


Met Leu Asp Leu Glu Lys Asp Lys Ile His Cys Cys Ala Leu Gly Trp 
        915                 920                 925             


Leu Ser Met Val Tyr Glu Gly Val Pro Gln Cys Gln Cys Ser Ser Met 
    930                 935                 940                 


Glu Glu Lys Glu Lys Asp Gln Cys Ser Leu Glu Ile Ser Asn Cys Lys 
945                 950                 955                 960 


Gln Gly Glu Gln Ala Cys Asn Ser Gly Ile Thr Ile Phe Glu Ile Asn 
                965                 970                 975     


Pro Ile Ser Asn Asn Ser Lys Ser Pro Leu Ile Gln Glu Ser Glu Lys 
            980                 985                 990         


Gly His Phe Ser Asp Ile His Gly  Glu Lys Ile Lys Thr  Ser Glu Thr 
        995                 1000                 1005             


Lys Asn  Ser Ser Ser Pro Arg  Val Glu Gln Glu Leu  Thr Gly His 
    1010                 1015                 1020             


Phe Ser  Met Lys Cys Tyr Gln  Lys Asp Lys Ser Thr  Thr Lys Gln 
    1025                 1030                 1035             


Asp Ser  Ser Leu Lys Thr Glu  Gln Lys Ile Lys Asn  Leu Ser Ser 
    1040                 1045                 1050             


Lys Cys  Asp Lys Pro Asn Pro  Leu Lys Ser Ser Lys  Ile Pro Thr 
    1055                 1060                 1065             


Pro Glu  Thr Phe Asn Val Val  Thr Ser Asn Ser Asp  Lys Asn Met 
    1070                 1075                 1080             


Pro Ala  Phe Ser Lys Gln Asp  Ser Gln Gly Ser Leu  Gln Lys Lys 
    1085                 1090                 1095             


His Leu  Phe Gln Asp Ser Asp  Pro Val Lys Gly His  Val Trp Leu 
    1100                 1105                 1110             


Leu Pro  Asn Lys Asp Pro Arg  Arg Arg Asn Thr Phe  Leu Val Gln 
    1115                 1120                 1125             


Ser Val  Ser Pro Glu Lys Lys  Lys Leu Lys Phe Lys  Ser Gly Ser 
    1130                 1135                 1140             


Ser Lys  Leu Lys Tyr Phe Glu  Lys Arg Lys Met Asp  His Leu Leu 
    1145                 1150                 1155             


Ile Ser  Asp Val Glu Ile Lys  Lys Lys Lys Tyr Glu  Lys Gln Glu 
    1160                 1165                 1170             


Gln Asn  Lys Asn Ala Gly Gly  Thr Leu Lys Leu Cys  Ser Thr Leu 
    1175                 1180                 1185             


Thr Glu  Pro Asn Glu Arg Ala  Cys Ala Lys Glu Lys  Ile Val Thr 
    1190                 1195                 1200             


Asn Ser  Glu Pro Ser Asp Ser  Lys Gly Ser Ser Ser  Lys Ser Thr 
    1205                 1210                 1215             


Arg Val  Ile Thr Val Gln Glu  Tyr Leu Gln Arg Lys  Lys Asp Lys 
    1220                 1225                 1230             


His Val  Ile Gly Asn Asn Ala  Ser Lys Asn Ile Cys  Val Glu Asn 
    1235                 1240                 1245             


Val Pro  Cys Asp Ser Glu Pro  Met Lys Ser Ser Lys  His Ser Ala 
    1250                 1255                 1260             


Ser Pro  Ser Leu Gly Lys Leu  Ile Glu Gly Gln Gly  Val Ser Ala 
    1265                 1270                 1275             


Glu Thr  Leu Lys Glu Val Glu  His Asn Ser Ser Ser  His Gly Lys 
    1280                 1285                 1290             


Asn Leu  Lys Thr His Arg Ser  Glu Glu Thr Arg Pro  Tyr Ser Val 
    1295                 1300                 1305             


Ser Asn  Ser Lys Glu Lys Phe  Tyr Arg Thr His Pro  Asp Lys Ser 
    1310                 1315                 1320             


Tyr Ile  Asp Lys Ala Lys Leu  Glu Arg Leu Thr Ser  Met Ser Ser 
    1325                 1330                 1335             


Lys Ser  Ser Gln Leu Gln Val  Lys Glu Lys Arg Lys  Gln Tyr Leu 
    1340                 1345                 1350             


Asn Arg  Val Ala Phe Lys Cys  Thr Glu Gln Glu Ser  Ile Cys Leu 
    1355                 1360                 1365             


Thr Lys  Leu Asp Ser Ala Ser  Lys Lys Leu Ser Lys  Glu Lys Glu 
    1370                 1375                 1380             


Lys Ser  Thr Ala Cys Ala Pro  Met Thr Lys Asp Tyr  Thr His Lys 
    1385                 1390                 1395             


Pro Met  Leu Glu Phe Lys Leu  Cys Pro Asp Val Leu  Leu Lys Asn 
    1400                 1405                 1410             


Thr Ser  Ser Ile Asp Lys Gly  Asp Asp Pro Arg Pro  Gly Pro Glu 
    1415                 1420                 1425             


Lys Glu  Arg Ala Pro Val Gln  Val Ser Gly Ile Lys  Thr Thr Lys 
    1430                 1435                 1440             


Glu Asp  Trp Leu Lys Cys Ile  Pro Thr Arg Thr Lys  Met Pro Glu 
    1445                 1450                 1455             


Ser Ser  Glu Gln Thr Asp Arg  Ala Asp Ser Arg Leu  Ser Lys Arg 
    1460                 1465                 1470             


Ser Phe  Ser Ala Asp Glu Phe  Glu Thr Leu Gln Asn  Pro Val Lys 
    1475                 1480                 1485             


Asp Ser  Asn Val Met Phe Arg  Thr Phe Lys Lys Met  Tyr Leu Glu 
    1490                 1495                 1500             


Lys Arg  Ser Arg Ser Leu Gly  Ser Ser Pro Val Lys  
    1505                 1510                 1515 


<210>  12
<211>  1747
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr 
1               5                   10                  15      


Pro Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile 
            20                  25                  30          


Thr Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu 
        35                  40                  45              


Ala Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu 
    50                  55                  60                  


Asn Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn 
65                  70                  75                  80  


Gly Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala 
                85                  90                  95      


Asn Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser 
            100                 105                 110         


Gly Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val 
        115                 120                 125             


His Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala 
    130                 135                 140                 


Asn Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu 
                165                 170                 175     


Pro Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu 
            180                 185                 190         


Gln Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr 
        195                 200                 205             


Pro Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser 
    210                 215                 220                 


Phe Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr 
225                 230                 235                 240 


Ser Leu Gln Val Lys Asn Ser Gln Leu Leu Asn Ser Val Leu Thr Leu 
                245                 250                 255     


Pro Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln 
            260                 265                 270         


Thr Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser 
        275                 280                 285             


Gln Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu 
    290                 295                 300                 


Val Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe 
305                 310                 315                 320 


Gln Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn 
                325                 330                 335     


Phe Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser 
            340                 345                 350         


Pro Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn 
        355                 360                 365             


Glu Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu 
    370                 375                 380                 


Asp Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu 
385                 390                 395                 400 


Val Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile 
                405                 410                 415     


Asn Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr 
            420                 425                 430         


Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr 
        435                 440                 445             


Ala Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn 
    450                 455                 460                 


Ala Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys 
465                 470                 475                 480 


Thr Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg 
                485                 490                 495     


Phe Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys 
            500                 505                 510         


Arg Pro Met Pro Asp Ser Ser His Asp Val Lys Val Leu Thr Ser Lys 
        515                 520                 525             


Thr Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser 
    530                 535                 540                 


Ser Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu 
545                 550                 555                 560 


Thr Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys 
                565                 570                 575     


Ile Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg 
            580                 585                 590         


Lys Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp 
        595                 600                 605             


Ser Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly 
    610                 615                 620                 


Asn Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val 
625                 630                 635                 640 


Ser Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser 
                645                 650                 655     


Thr Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val 
            660                 665                 670         


Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala 
        675                 680                 685             


Lys Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly 
    690                 695                 700                 


Ile Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val 
705                 710                 715                 720 


Gly Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr 
                725                 730                 735     


Ala Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile 
            740                 745                 750         


Thr Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu 
        755                 760                 765             


Ser Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu 
    770                 775                 780                 


Pro Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu 
785                 790                 795                 800 


Gln Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val 
                805                 810                 815     


Asp Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe 
            820                 825                 830         


Pro Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser 
        835                 840                 845             


Glu Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser 
    850                 855                 860                 


Ala Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg 
865                 870                 875                 880 


Asn Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys 
                885                 890                 895     


Ser Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile 
            900                 905                 910         


Phe Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu 
        915                 920                 925             


Pro Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp 
    930                 935                 940                 


Asn Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val 
945                 950                 955                 960 


Gln Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu 
                965                 970                 975     


Pro Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile 
            980                 985                 990         


Leu Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn 
        995                 1000                 1005             


Asp Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln 
    1010                 1015                 1020             


Glu Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg 
    1025                 1030                 1035             


Asn Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp 
    1040                 1045                 1050             


Gln Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala 
    1055                 1060                 1065             


Val Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln 
    1070                 1075                 1080             


Thr Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys 
    1085                 1090                 1095             


Asp Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln 
    1100                 1105                 1110             


Met Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val 
    1115                 1120                 1125             


Asp Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Asp Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys 
    1160                 1165                 1170             


Ala Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys 
    1175                 1180                 1185             


Gln Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Lys Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly 
    1205                 1210                 1215             


Glu Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser 
    1220                 1225                 1230             


Leu Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe 
    1235                 1240                 1245             


Pro Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys 
    1250                 1255                 1260             


His Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln 
    1265                 1270                 1275             


Phe Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys 
    1280                 1285                 1290             


Arg Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn 
    1295                 1300                 1305             


Lys Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln 
    1310                 1315                 1320             


Lys Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr 
    1325                 1330                 1335             


Ala Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu 
    1340                 1345                 1350             


Gly Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser 
    1355                 1360                 1365             


Val Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu 
    1370                 1375                 1380             


Asp Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys 
    1385                 1390                 1395             


Gly Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn 
    1400                 1405                 1410             


Pro Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr 
    1415                 1420                 1425             


Lys Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile 
    1430                 1435                 1440             


Leu Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala 
    1445                 1450                 1455             


Leu Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro 
    1460                 1465                 1470             


Cys Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val 
    1475                 1480                 1485             


Glu Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln 
    1490                 1495                 1500             


Thr Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn 
    1505                 1510                 1515             


Leu Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu 
    1520                 1525                 1530             


Arg Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile 
    1535                 1540                 1545             


Trp Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn 
    1550                 1555                 1560             


Glu Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys 
    1565                 1570                 1575             


Lys Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu 
    1580                 1585                 1590             


Ser Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His 
    1595                 1600                 1605             


Lys Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val 
    1610                 1615                 1620             


Lys Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys 
    1625                 1630                 1635             


Pro Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys 
    1640                 1645                 1650             


Asp Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val 
    1655                 1660                 1665             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala 
    1670                 1675                 1680             


Thr Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val 
    1685                 1690                 1695             


Asn Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu 
    1700                 1705                 1710             


Met Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr 
    1715                 1720                 1725             


Tyr Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser 
    1730                 1735                 1740             


Ser Pro  Val Lys 
    1745         


<210>  13
<211>  1747
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr 
1               5                   10                  15      


Pro Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile 
            20                  25                  30          


Thr Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu 
        35                  40                  45              


Ala Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu 
    50                  55                  60                  


Asn Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn 
65                  70                  75                  80  


Gly Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala 
                85                  90                  95      


Asn Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser 
            100                 105                 110         


Gly Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val 
        115                 120                 125             


His Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala 
    130                 135                 140                 


Asn Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu 
                165                 170                 175     


Pro Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu 
            180                 185                 190         


Gln Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr 
        195                 200                 205             


Pro Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser 
    210                 215                 220                 


Phe Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr 
225                 230                 235                 240 


Ser Leu Gln Val Lys Asn Ser Gln Leu Leu Asn Ser Val Leu Thr Leu 
                245                 250                 255     


Pro Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln 
            260                 265                 270         


Thr Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser 
        275                 280                 285             


Gln Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu 
    290                 295                 300                 


Val Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe 
305                 310                 315                 320 


Gln Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn 
                325                 330                 335     


Phe Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser 
            340                 345                 350         


Pro Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn 
        355                 360                 365             


Glu Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu 
    370                 375                 380                 


Asp Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu 
385                 390                 395                 400 


Val Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile 
                405                 410                 415     


Asn Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr 
            420                 425                 430         


Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr 
        435                 440                 445             


Ala Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn 
    450                 455                 460                 


Ala Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys 
465                 470                 475                 480 


Thr Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg 
                485                 490                 495     


Phe Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys 
            500                 505                 510         


Arg Pro Met Pro Asp Pro Ser His Asp Val Lys Val Leu Thr Ser Lys 
        515                 520                 525             


Thr Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser 
    530                 535                 540                 


Ser Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu 
545                 550                 555                 560 


Thr Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys 
                565                 570                 575     


Ile Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg 
            580                 585                 590         


Lys Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp 
        595                 600                 605             


Ser Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly 
    610                 615                 620                 


Asn Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val 
625                 630                 635                 640 


Ser Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser 
                645                 650                 655     


Thr Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val 
            660                 665                 670         


Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala 
        675                 680                 685             


Lys Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly 
    690                 695                 700                 


Ile Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val 
705                 710                 715                 720 


Gly Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr 
                725                 730                 735     


Ala Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile 
            740                 745                 750         


Thr Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu 
        755                 760                 765             


Ser Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu 
    770                 775                 780                 


Pro Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu 
785                 790                 795                 800 


Gln Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val 
                805                 810                 815     


Asp Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe 
            820                 825                 830         


Pro Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser 
        835                 840                 845             


Glu Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser 
    850                 855                 860                 


Ala Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg 
865                 870                 875                 880 


Asn Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys 
                885                 890                 895     


Ser Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile 
            900                 905                 910         


Phe Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu 
        915                 920                 925             


Pro Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp 
    930                 935                 940                 


Asn Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val 
945                 950                 955                 960 


Gln Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu 
                965                 970                 975     


Pro Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile 
            980                 985                 990         


Leu Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn 
        995                 1000                 1005             


Asp Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln 
    1010                 1015                 1020             


Glu Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg 
    1025                 1030                 1035             


Asn Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp 
    1040                 1045                 1050             


Gln Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala 
    1055                 1060                 1065             


Val Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln 
    1070                 1075                 1080             


Thr Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys 
    1085                 1090                 1095             


Asp Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln 
    1100                 1105                 1110             


Met Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val 
    1115                 1120                 1125             


Asp Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Asp Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys 
    1160                 1165                 1170             


Ala Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys 
    1175                 1180                 1185             


Gln Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Lys Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly 
    1205                 1210                 1215             


Glu Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser 
    1220                 1225                 1230             


Leu Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe 
    1235                 1240                 1245             


Pro Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys 
    1250                 1255                 1260             


His Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln 
    1265                 1270                 1275             


Phe Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys 
    1280                 1285                 1290             


Arg Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn 
    1295                 1300                 1305             


Lys Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln 
    1310                 1315                 1320             


Lys Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr 
    1325                 1330                 1335             


Ala Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu 
    1340                 1345                 1350             


Gly Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser 
    1355                 1360                 1365             


Val Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu 
    1370                 1375                 1380             


Asp Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys 
    1385                 1390                 1395             


Gly Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn 
    1400                 1405                 1410             


Pro Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr 
    1415                 1420                 1425             


Lys Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile 
    1430                 1435                 1440             


Leu Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala 
    1445                 1450                 1455             


Leu Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro 
    1460                 1465                 1470             


Cys Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val 
    1475                 1480                 1485             


Glu Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln 
    1490                 1495                 1500             


Thr Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn 
    1505                 1510                 1515             


Leu Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu 
    1520                 1525                 1530             


Arg Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile 
    1535                 1540                 1545             


Trp Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn 
    1550                 1555                 1560             


Glu Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys 
    1565                 1570                 1575             


Lys Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu 
    1580                 1585                 1590             


Ser Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His 
    1595                 1600                 1605             


Lys Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val 
    1610                 1615                 1620             


Lys Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys 
    1625                 1630                 1635             


Pro Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys 
    1640                 1645                 1650             


Asp Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val 
    1655                 1660                 1665             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala 
    1670                 1675                 1680             


Thr Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val 
    1685                 1690                 1695             


Asn Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu 
    1700                 1705                 1710             


Met Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr 
    1715                 1720                 1725             


Tyr Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser 
    1730                 1735                 1740             


Ser Pro  Val Lys 
    1745         


<210>  14
<211>  1521
<212>  PRT
<213>  Mus musculus

<400>  14

Met Asn Trp Asn Thr Lys Gln Glu Asn Val Pro Lys Pro Pro Pro Tyr 
1               5                   10                  15      


Ser Lys Thr Gln Ser Ser Ile Leu Gln His Phe Leu Met Thr Ser Thr 
            20                  25                  30          


Thr Ser Gln Ser Ser Phe Asn Tyr Ser Pro His Asn Gln Glu Ala Ser 
        35                  40                  45              


Gln Thr Ser Phe Asn Tyr Ser Leu His Asn Gln Glu Ala Cys Met Tyr 
    50                  55                  60                  


Ser Gly Asn Ser Asn Ser Val Ser Gln Pro Leu Leu Ser Gly Arg Asn 
65                  70                  75                  80  


Tyr Ile Thr Pro Gln Thr Gln Ile Ser Val Ser Asn Met Pro Thr Arg 
                85                  90                  95      


Thr Ile Val Ala Ser Gln Ser Ser Met Glu Arg Val Val Ser Thr Asn 
            100                 105                 110         


Gly Lys Gly Pro Gln Gln Pro Asn His Asn Leu Gln Thr Val Ser Ser 
        115                 120                 125             


Gly Ile Met Gln Asn Val Trp Leu Pro Ser His Thr Glu Ala Thr Ile 
    130                 135                 140                 


Ser His Asn Pro Asp Gly Gly Thr Asn Met Pro Tyr Met His Pro Pro 
145                 150                 155                 160 


Gln Asn Gln Leu Val Thr Ser Asp Thr Tyr Ser Met Gln Leu Gln Met 
                165                 170                 175     


Ala Pro Leu His Ser Gly Lys Val Pro Met Thr His Gln Gly Ser Gln 
            180                 185                 190         


Gly Leu Asn His Phe Ile Pro Asp Gln Leu Val Asp Trp Thr Gln Tyr 
        195                 200                 205             


Thr Ser Asn Glu Leu Ser Tyr Pro Glu Tyr Arg Pro Pro Pro Lys Gln 
    210                 215                 220                 


Tyr Ser Tyr Ile Leu Pro Ala Thr Thr Ser Leu Gln Val Lys Asn Asn 
225                 230                 235                 240 


Gln Leu Pro Thr Tyr Thr Gln Ser Leu Gln Ser Lys His Ser Val Pro 
                245                 250                 255     


Leu Ser Ser His Gln Tyr Ala Ala Glu Ala Ser Lys Arg Leu Ser Ala 
            260                 265                 270         


Leu Pro Tyr Ser Cys Arg Tyr Glu Asn Gln His Val Gln Asn Ala Gln 
        275                 280                 285             


Pro Val Ser Lys His Leu Pro Met Glu Val Pro Gln Ser Ser Glu Val 
    290                 295                 300                 


His Ser Ser Glu Lys Lys Lys Asp Thr Tyr Arg Gly Phe Lys Gln Gln 
305                 310                 315                 320 


Trp Gln Asn Pro Asn Glu Lys Val Ser Ile Gly Gln Phe Ser Glu Val 
                325                 330                 335     


Lys Ile Asn Ile Lys Gln Pro Tyr Ser Glu Ser Val Arg Pro Ser Gly 
            340                 345                 350         


Asp Gly Val Gln Ala Leu Val Gln Asn Asn Gln Glu Lys Arg Lys Tyr 
        355                 360                 365             


Thr Tyr Asn Pro Asn Thr Asn Gln Val Ile Asp Thr Asn Ala Thr Lys 
    370                 375                 380                 


Glu Lys Leu Val Arg Asp Ile Lys Ser Leu Val Glu Ile Lys Lys Lys 
385                 390                 395                 400 


Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile Asn Lys Ser Leu Leu Met 
                405                 410                 415     


Ala Ala Gly Cys Ser Lys Thr Ala Asn Thr Ser Tyr Thr Glu Pro Ile 
            420                 425                 430         


Gln His Ser Glu Phe Ser Ala Lys Glu Met Ser Ala Lys Asn Gly Asn 
        435                 440                 445             


Asp Cys Ser Met Glu Leu Leu Ala Thr Cys Leu Ser Leu Trp Lys Asn 
    450                 455                 460                 


Gln Pro Ser Lys Thr Thr Glu Glu Asn Val Pro Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Lys Gln Cys Asn Thr Ser Arg Ile Ser Thr Thr Val Val Gly Ser Ala 
                485                 490                 495     


Asn Pro Thr Asn Glu Val His Val Lys Ser Leu Cys Ser Gly Val Gly 
            500                 505                 510         


Asn Ser Gln Lys Met Met Ser Ser Ser Gln Thr Val Leu Pro Val Leu 
        515                 520                 525             


Ile Pro Ser Cys Glu Ser Ser Gly Val Ala Val Gly Lys Gly Thr Glu 
    530                 535                 540                 


Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu Ser Asp Thr Asn Thr 
545                 550                 555                 560 


Leu Pro Gly Lys Asp Ser Val Pro Glu Val Leu Pro Glu Thr Leu Tyr 
                565                 570                 575     


Pro Val Val Lys Glu Gly Ser Val Cys Ser Leu Gln Thr Gln Pro Thr 
            580                 585                 590         


Glu Thr Val Ala Leu Pro Phe Asp Val Ile Gly Ala Val Ala Ser Asn 
        595                 600                 605             


Asn Ile Ser Ala Glu Ile Pro Leu Pro Val Asp Lys Glu Lys Gln His 
    610                 615                 620                 


Lys Pro Ile Gln Gly Asp Pro Asp Ile Ala Asp Ser Ser Leu Gly Lys 
625                 630                 635                 640 


His Ser Pro Leu Gly Thr Glu Val Leu Pro Lys Pro Met Asp Ser Thr 
                645                 650                 655     


Ile Val Ser Gly Pro Met Leu Gln Ile Glu Ser Ile Cys Ser Leu Ala 
            660                 665                 670         


Glu Gly Asp Val Ser Tyr Asn Ser Gln Ile Ala Glu Ile Phe Asn Ser 
        675                 680                 685             


Val Gln Thr Glu Pro Gln Lys Pro Ser Pro Asn Gln Val Ile Asp Ser 
    690                 695                 700                 


Gln Gln Glu Gln Val Tyr Asp Thr Thr Glu Asn Lys Asp Phe Ser Leu 
705                 710                 715                 720 


Gln Lys Asp Lys Cys Val Gln Cys Thr Asp Val Pro His Glu Val Pro 
                725                 730                 735     


Glu Gln Pro Glu Pro Leu Gln Pro Glu Glu Pro Ala Ser Ser Glu Tyr 
            740                 745                 750         


Val Glu Ala Asn Arg Glu Ala Thr Glu Glu Ser Cys Arg Glu Tyr Thr 
        755                 760                 765             


Gly Arg Lys Glu Ser Thr Ala Lys Asp Val Cys Leu Pro Ala Ala Ile 
    770                 775                 780                 


Gln Gln Asp Pro His Pro Arg Glu Thr Asp Met Phe Ser Lys Ser Asp 
785                 790                 795                 800 


His Ser Leu Pro Ala Ile Asn Glu Ile Asn Asp Glu Ser Glu Pro Ile 
                805                 810                 815     


Ser Tyr Leu His Asp Gln Leu Ser Glu Leu Leu Lys Glu Phe Pro Tyr 
            820                 825                 830         


Gly Ile Glu Thr Phe Asn Arg His Glu Val Ser Leu Asp Gln Gln Lys 
        835                 840                 845             


Thr His Lys Ile Val Glu Asn Gln Thr Gly Gly Lys Thr Ser Asn Val 
    850                 855                 860                 


Ser Gly Asp Ser Thr Asp Gln Ile Lys Ile Thr Val Leu Asn Ser Glu 
865                 870                 875                 880 


Gln Ile Lys Glu Leu Phe Pro Glu Asp Asp Gln Pro Cys Asp Lys Leu 
                885                 890                 895     


Ala Glu Pro Glu Asn Lys Glu Ile Val Ala Glu Val Lys Ser Pro Cys 
            900                 905                 910         


Asp Ser Gln Ile Pro Arg Glu Glu Ser His Asp Leu Gly Met Leu Asp 
        915                 920                 925             


Pro Glu Lys Asp Lys Ile His Cys Cys Ala Leu Gly Trp Leu Ser Met 
    930                 935                 940                 


Val Tyr Glu Gly Val Pro Gln Cys His Cys Ser Ser Thr Glu Lys Lys 
945                 950                 955                 960 


Glu Lys Asp Gln Cys Leu Asp Ile Asn Ser Ser Lys Gln Gly Glu Gln 
                965                 970                 975     


Pro Cys Asn Ser Gly Ile Thr Ile Phe Glu Ile Asn Pro Val Ser Asn 
            980                 985                 990         


Asn Ser Lys Thr Pro Leu Thr Gln  Ala Thr Glu Glu Gly  His Phe Ser 
        995                 1000                 1005             


Ala Val  His Gly Glu Lys Thr  Lys Ala Ser Lys Thr  Lys Asp Asn 
    1010                 1015                 1020             


Arg Glu  Gly Gln Glu Leu Ala  Cys His Phe Ser Ala  Lys Cys Tyr 
    1025                 1030                 1035             


Lys Lys  Asp Lys Lys Gly Asn  Phe Lys Ile Arg His  Asp Thr Ser 
    1040                 1045                 1050             


Leu Lys  Met Glu Gln Lys Leu  Lys Asn Ile Ser Ser  Lys Cys Asp 
    1055                 1060                 1065             


Ile Pro  Asn Pro Ser Lys Cys  Asn Lys Ile Ala Ala  Pro Glu Ile 
    1070                 1075                 1080             


Leu His  Val Thr Thr Ser Asn  Ser Ala Lys Asn Met  Pro Phe Ser 
    1085                 1090                 1095             


Lys Gln  Ala Ser Gln Glu Ser  Leu Gln Lys Lys His  Thr Ser Gln 
    1100                 1105                 1110             


Asp Leu  Gly Pro Val Lys Ala  Pro Ile Glu Leu Ser  Ser Asn Thr 
    1115                 1120                 1125             


Asp Pro  Cys Arg Ser Asn Thr  Ser Ser Val Gln Ser  Val Ser Pro 
    1130                 1135                 1140             


Glu Lys  Lys Lys Leu Lys Phe  Lys Ala Gly Gly Ser  Arg Leu Lys 
    1145                 1150                 1155             


Tyr Phe  Glu Lys Arg Lys Thr  Asp His Val Ile Ile  Pro Asp Val 
    1160                 1165                 1170             


Glu Ile  Lys Lys Lys Lys Tyr  Glu Lys Gln Glu Gln  Asn Lys Asn 
    1175                 1180                 1185             


Ala Gly  Asp Thr Leu Lys Leu  Cys Ser Ile Leu Thr  Glu Ser Asn 
    1190                 1195                 1200             


Glu Arg  Ala Ser Val Gln Glu  Lys Thr Val Pro Ser  Pro Glu Ser 
    1205                 1210                 1215             


Ser Asp  Pro Lys Gly Ser Ser  Ser Lys Ser Thr Arg  Val Ile Thr 
    1220                 1225                 1230             


Val Gln  Glu Tyr Leu Gln Arg  Gln Lys Asp Lys Gln  Ile Thr Gly 
    1235                 1240                 1245             


Asn Asn  Ala Ser Arg Asn Ile  Cys Val Glu Thr Val  Leu Cys Asp 
    1250                 1255                 1260             


Ser Gly  His Thr Lys Thr Ser  Lys His Ser Ala Ala  Val Ser Trp 
    1265                 1270                 1275             


Gly Lys  Leu Val Glu Gly Gln  Ser Ile Ser Ala Glu  Thr Ala Lys 
    1280                 1285                 1290             


Glu Leu  Glu His Asn Ser Ser  Ser His Gly Lys Asp  Phe Lys Ile 
    1295                 1300                 1305             


His His  Ser Glu Ala Ser Arg  Thr His Ser Val Ser  Asn Asn Asn 
    1310                 1315                 1320             


Lys Gly  Lys Phe Asp Gly Lys  Gln Pro Asp Lys Met  Phe Lys Asn 
    1325                 1330                 1335             


Lys Thr  Ser Met Asn Asn Glu  Ser Asn Gln Met Pro  Leu Gln Val 
    1340                 1345                 1350             


Lys Glu  Gln Arg Lys Gln Tyr  Leu Asn Arg Val Ala  Phe Lys Cys 
    1355                 1360                 1365             


Thr Glu  Arg Glu Ser Ile Cys  Leu Thr Lys Leu Asp  Ser Ala Ser 
    1370                 1375                 1380             


Lys Lys  Leu Ser Ile Glu Lys  Lys Ser Gly Glu Tyr  Thr Ser Lys 
    1385                 1390                 1395             


Thr Lys  Asp Thr Asp Lys Pro  Ser Met Leu Glu Phe  Lys Leu Cys 
    1400                 1405                 1410             


Pro Asp  Val Leu Leu Lys Asn  Thr Ser Thr Val Asp  Lys Gln Asp 
    1415                 1420                 1425             


Cys Pro  Gly Pro Gly Pro Glu  Lys Glu Gln Ala Pro  Val Gln Val 
    1430                 1435                 1440             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Cys Ile Pro 
    1445                 1450                 1455             


Thr Arg  Thr Lys Met Pro Glu  Ser Ser Gln Arg Asp  Ser Ala Asp 
    1460                 1465                 1470             


Ser Arg  Leu Ser Lys Arg Ser  Leu Ser Ala Asp Glu  Phe Glu Ile 
    1475                 1480                 1485             


Leu Gln  Asn Pro Val Lys Glu  Ser Asn Ile Met Phe  Arg Thr Tyr 
    1490                 1495                 1500             


Lys Lys  Met Tyr Leu Glu Lys  Arg Ser Arg Ser Leu  Gly Ser Ser 
    1505                 1510                 1515             


Pro Val  Lys 
    1520     


<210>  15
<211>  1741
<212>  PRT
<213>  Bos taurus

<400>  15

Met Asn Trp Asn Ala Lys Pro Glu Ser Val Thr Leu Pro Pro Gln Tyr 
1               5                   10                  15      


Pro Lys Lys Gln Ala Ser Phe Leu Glu Gln Gly Leu Val Asn Thr Leu 
            20                  25                  30          


Ser Thr Thr Ser Gln Ser Ser Phe His Thr Gly Ser Asn Gln Glu Pro 
        35                  40                  45              


Cys Leu Phe Leu Ser Asn Ser His Pro Val Ser Gln Pro Leu Leu Asn 
    50                  55                  60                  


Ile Arg Asn His Lys Thr Pro Pro Gln Ile Pro Ile Ser Asp Leu His 
65                  70                  75                  80  


Ser Gly Thr Ile Val Thr Ser Gln Thr Ser Val Glu Arg Ile Thr Tyr 
                85                  90                  95      


Ala Asn Val Lys Gly Pro Lys Gln Leu Ser His Asp Leu Gln Ile Ser 
            100                 105                 110         


Ser Gly Val Thr Pro Asp Val Trp Leu Asn Ser Pro Met Gly Ser Ser 
        115                 120                 125             


Thr Leu Ser His Thr Gly Ala Thr Val Ser His Gln Thr Gly Phe Gly 
    130                 135                 140                 


Thr Asn Val Pro Asn Val His Ala Leu Gln Asn Gln Phe Leu Thr Ser 
145                 150                 155                 160 


Asp Thr Tyr Ser Met Gln Leu His Met Ile Pro Ser Asn Ser Gly Arg 
                165                 170                 175     


Val Pro Ile Thr Tyr Gln Gly Asn Thr Arg Leu Asn Leu Pro Leu Ser 
            180                 185                 190         


Glu Gln Gln Val Asp Trp Ala Pro Gln Arg Ala Ser Ser Gly Leu Thr 
        195                 200                 205             


Tyr Gln Asp Tyr Arg Pro Leu Pro Lys Gln Tyr Asn Tyr Ser Pro Arg 
    210                 215                 220                 


Ser Phe Leu Gln Glu Pro Ala Leu Gln Lys Gln Asn Ala Met Ser Ser 
225                 230                 235                 240 


Val Ser Phe Gln Val Lys Asn Asn Gln Ser Pro Asn Pro Ala Leu Thr 
                245                 250                 255     


Phe Lys Ser Lys Gln Ile Ala Ala Val Pro Ser Tyr Gln Tyr Ala Val 
            260                 265                 270         


Thr Gln Thr Asp Lys Arg Pro Pro Pro Pro Tyr Asp Cys Arg Tyr Ala 
        275                 280                 285             


Ser Gln Ser Leu Gln Ser Thr Pro Arg Val Val Lys Gln Ser Ser Met 
    290                 295                 300                 


Glu Val Pro Gln Ser Gln Glu Met His Leu Pro Glu Met Arg Lys Asp 
305                 310                 315                 320 


Phe Cys Arg Asp Phe Gln Gln Gln Trp Gln Asn Leu Asn Glu Asn Phe 
                325                 330                 335     


Ser Met Met Gly Gly Ser Cys Asn Leu Lys Val Asn Thr Ser Val Asn 
            340                 345                 350         


His Pro Phe Asn Glu Pro Val Arg Ser Ser Val Thr Gly Ala Gln Ala 
        355                 360                 365             


Leu Ala Gln Asn Asn Gln Glu Arg Thr Val Asp Ser Gln Asn Leu Thr 
    370                 375                 380                 


Ser Asn Gln Ala Leu Asp Thr Ser Ala Thr Lys Glu Lys Leu Val Arg 
385                 390                 395                 400 


Asp Ile Lys Thr Leu Val Glu Ile Lys Lys Lys Phe Ser Asp Leu Ala 
                405                 410                 415     


Arg Lys Ile Lys Ile Asn Lys Ser Leu Leu Met Ala Ala Gly Cys Ile 
            420                 425                 430         


Lys Thr Pro Asn Thr Ser Tyr Ser Glu Ser Ala Gln Asn Ser Gly Leu 
        435                 440                 445             


Ser Leu Lys Gln Thr Ala Lys Ile Gln Ser Glu Pro Gln Leu Thr Leu 
    450                 455                 460                 


Val Thr Pro Glu Ile Val Glu Asp Lys Pro Pro Thr Val Met Glu Ser 
465                 470                 475                 480 


Ala Glu Glu Thr Asn Arg Pro Gln Arg Val Leu Ser Ser Asn Leu Gln 
                485                 490                 495     


Asp Arg Asn Phe Asn Gln Val Ser Ser Val Ser Leu Asn Ser Ala Cys 
            500                 505                 510         


Ser Glu Lys Leu Pro Ile Pro Glu Gln Val His Asp Leu Glu Val Val 
        515                 520                 525             


Asn Ser Leu Lys Thr Ser Thr Val Glu Val Thr Gln Ala Pro Leu Asn 
    530                 535                 540                 


Asn Thr Gln Leu Ser Ser Gly Asn Ser Val Ser Ile Ala Gln Asn Val 
545                 550                 555                 560 


Pro Thr Asn Ser Glu Val Thr Phe Leu Pro His Ser Thr Ser Ser Glu 
                565                 570                 575     


Glu Tyr Ile Ser Lys Tyr Pro Asn Lys Asn Arg Leu Ile Leu Ser Leu 
            580                 585                 590         


Leu Thr Ser Gly Ser Lys Thr Gln Lys Lys Leu Leu Lys Asp Thr Gly 
        595                 600                 605             


Glu Cys Ile His Asp Ser Lys Leu His Asn Phe Glu Met Asn Ala Asn 
    610                 615                 620                 


Thr Glu Asn Thr Gly Asn Gln Leu Lys Thr Thr Glu Thr Val Asn Leu 
625                 630                 635                 640 


Pro Arg Thr Cys Asn Arg Asn Ala Lys Val Ala Asp Thr Ser Cys Leu 
                645                 650                 655     


Glu Cys Lys Ser Phe Asn Gly Val Ser Ser Asn Ser Gly Ser Arg Phe 
            660                 665                 670         


Ser Met Glu Leu Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro 
        675                 680                 685             


Ser Glu Pro Thr Lys Glu Lys Gln Asp Asn Glu Ser Lys Thr Asn Ile 
    690                 695                 700                 


Thr Ala Ile Ala Val Ser Lys Pro Ala Pro Ile Cys Glu Ser Ser Pro 
705                 710                 715                 720 


Phe Ser Pro Val Gly Asn Ser Gln Asn Lys Ile Val Asn Ser Ser Leu 
                725                 730                 735     


Glu Thr Ile Ser Ser Val Val Ala Gln Asn Tyr Glu Ser Ser Gly Thr 
            740                 745                 750         


Thr Thr Thr Lys Gly Ile Ala Val Val Ser Pro Leu Ile Leu Ser Asp 
        755                 760                 765             


Val Asn Thr Leu Ser Val Lys Asp Thr Thr Ser Glu Ala Leu Pro Glu 
    770                 775                 780                 


Met Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu Gln Asn 
785                 790                 795                 800 


Lys Leu Thr Glu Asn Thr Ala Ala Leu Lys Ile Asn Val Asn Glu Pro 
                805                 810                 815     


Val Thr Ser Thr Thr Gly Ile Met Ile Phe Pro Leu Ile Glu Asp Lys 
            820                 825                 830         


Gln Ser Glu Ser Thr Asn Thr Asn Ser Glu Gly Ile Pro Asn Thr Asn 
        835                 840                 845             


Gln Gly Lys His Asn Glu Ser Glu Pro Asp Ile Gln Cys Pro Val Ser 
    850                 855                 860                 


Asp Gln Gln Thr Ser Tyr Ile Ser Lys Asp Ser Ser Ser Val Gly Ser 
865                 870                 875                 880 


Asp Val Leu Gln Ile Gly Ser Ile Cys Ser Leu Val Glu Gly Asp Thr 
                885                 890                 895     


Ser Tyr Asp Ser Gln Ile Ala Glu Ile Phe Asn Leu Leu Pro Leu Gln 
            900                 905                 910         


Lys Val Glu Pro Gln Lys Pro Leu Pro Asn His Gln Met Met Ser Ser 
        915                 920                 925             


Arg Gln Gln Asn Glu His Leu Glu Asn Ile Thr Glu Ser Lys Asp Phe 
    930                 935                 940                 


Asp Phe Lys Lys Asp Glu Phe Val Gln Cys Thr Asp Val Ser Asn Lys 
945                 950                 955                 960 


Ile Thr Asp Gln Ser Glu Ser Leu Gln Leu Pro Ala Leu Ser Pro Leu 
                965                 970                 975     


Lys Cys Val Glu Ala Lys Ser Gly Ile Leu Glu Glu Gly Ser Leu Glu 
            980                 985                 990         


His Ile Thr Glu Asn Glu Ser Met  Ala Asn Asp Thr Cys  Ser Ser Ala 
        995                 1000                 1005             


Ala Thr  Gln Gln Asp Ser Tyr  Pro Gln Glu Ala Asp  Thr Ser Cys 
    1010                 1015                 1020             


Ser Tyr  Thr Glu Gln Asp Pro  Thr Thr Asp Glu Ser  Leu His Asp 
    1025                 1030                 1035             


Lys Thr  Ser Ile Leu Tyr Leu  His Asp Gln Leu Ser  Glu Leu Leu 
    1040                 1045                 1050             


Lys Glu  Phe Pro Tyr Gly Ile  Glu Pro Val Asn Met  His Glu Ser 
    1055                 1060                 1065             


Ser Val  Val Gln Gln Met Ala  Asn Gln Ile Ser Glu  Ala Gln Thr 
    1070                 1075                 1080             


Cys Gly  Lys Thr Asp Cys Asp  Ser Lys Gly Ser Thr  Asp Gln Ile 
    1085                 1090                 1095             


Gln Ile  Thr Ile Leu Asn Thr  Asp Gln Met Lys Glu  Leu Phe Pro 
    1100                 1105                 1110             


Glu Gln  Asp Asp Gln Pro Ser  Glu Val Asp Lys Leu  Thr Glu Pro 
    1115                 1120                 1125             


Gln Lys  Glu Lys Pro Val Thr  Lys Glu Glu Lys Gln  Cys Asp Pro 
    1130                 1135                 1140             


Gln Ala  Cys Arg Val Glu Glu  Arg Cys Ala Ser Val  Pro Leu Asp 
    1145                 1150                 1155             


Ser Glu  Lys Asp Asp Ile Arg  Cys Cys Ala Leu Gly  Trp Leu Ser 
    1160                 1165                 1170             


Met Val  Tyr Glu Gly Val Pro  Gln Cys Gln Cys Asn  Ser Ile Lys 
    1175                 1180                 1185             


Lys Ser  Asp Ser Lys Glu Lys  Lys Gln Ile Asn Pro  Cys Ser Pro 
    1190                 1195                 1200             


Ser Glu  Ala Lys Ser Tyr Lys  Gln Gly Glu Arg Thr  Ser Asp Arg 
    1205                 1210                 1215             


Asp Val  Pro Val Ala Leu Asn  Ser Pro Pro Asn Asn  Pro Pro Lys 
    1220                 1225                 1230             


Ser Pro  Leu Thr Ser Ser Val  Glu Lys Lys His Phe  Pro Glu Thr 
    1235                 1240                 1245             


Lys Gln  Ser Ser Asn Ile Lys  Asp Lys Ser Lys Thr  Glu Arg Asn 
    1250                 1255                 1260             


Ser Ser  Leu Arg Thr Glu Gln  Glu Leu Ser Gly Gln  Leu Leu Ser 
    1265                 1270                 1275             


Lys Gly  Asp Lys Lys Leu Asp  Ser Leu Gln Ser His  Lys Arg Lys 
    1280                 1285                 1290             


Arg Asn  Leu Gln Phe His Glu  Val Asn Phe Asn Ser  Ala Asn Lys 
    1295                 1300                 1305             


Ile Thr  Lys Phe Ser Gln Glu  Ser Leu Gln Arg Lys  Phe Met Ala 
    1310                 1315                 1320             


Gln Asn  Leu Gly Pro Leu Lys  Pro Lys Met Ser Phe  Leu Thr Ser 
    1325                 1330                 1335             


Lys Thr  Lys Asp Leu Asn Met  Lys Asn Gly Ser Ser  Val Gln Ser 
    1340                 1345                 1350             


Val Ser  Pro Glu Lys Arg Lys  Leu Lys Ser Ala Gly  Ser Lys Gln 
    1355                 1360                 1365             


Lys Ser  Leu Glu Glu Arg Lys  Leu Asp Glu Gly Ile  Thr Leu Asp 
    1370                 1375                 1380             


Ser Glu  Ile Lys Arg Lys Lys  His Asp Lys Gln Glu  Gln Asn Lys 
    1385                 1390                 1395             


Asn Val  Gly Gly Gly Ala Phe  Lys Phe Cys Asn Phe  Ser Thr Pro 
    1400                 1405                 1410             


Asn Glu  Arg Ala Trp Ile Lys  Glu Lys Thr Val Ser  Asn Val Lys 
    1415                 1420                 1425             


Ser Ser  Gly Ser Lys Asp Ser  Ser Ser Lys Met Asn  Arg Val Leu 
    1430                 1435                 1440             


Ser Pro  Lys Glu Tyr Leu Ser  Arg Gln Lys His Lys  Glu Ala Leu 
    1445                 1450                 1455             


Lys Lys  Asn Tyr Leu Lys Asn  Ser Asp Ser Gln Tyr  Met Arg Pro 
    1460                 1465                 1470             


Ser Lys  Leu Ser Val Gln Val  Glu Ser Ser Gly Lys  Ser Asn Glu 
    1475                 1480                 1485             


Arg Pro  Asn Gly Ser Val Gln  Thr Cys Lys Glu Ser  Leu Asn Ile 
    1490                 1495                 1500             


Gly Thr  Gly His Gly Lys Ser  Ile Lys Thr His His  Ser Lys Glu 
    1505                 1510                 1515             


Ser Lys  Thr Tyr Ile Ser Arg  Asn Ile Lys Gly Thr  Val Gly Gly 
    1520                 1525                 1530             


Lys Gln  Ser Asp Lys Met Trp  Ile Asp Arg Thr Lys  Leu Asp Lys 
    1535                 1540                 1545             


Asn Leu  Asn Asn Ile Asn Asn  Glu Gly Glu Leu Ser  Gln Met Ser 
    1550                 1555                 1560             


Ser Gln  Thr Lys Asp Gln Arg  Lys Leu Tyr Leu Asn  Arg Val Ala 
    1565                 1570                 1575             


Phe Lys  Cys Thr Glu Arg Glu  Arg Ile Cys Leu Thr  Lys Leu Asp 
    1580                 1585                 1590             


Asn Ser  Pro Arg Lys Leu Lys  Glu Lys Arg Pro Glu  Ser Lys Cys 
    1595                 1600                 1605             


Lys Asn  Pro Leu Pro Val Lys  Asp Thr Thr Glu Lys  Leu Ser Met 
    1610                 1615                 1620             


Leu Glu  Phe Lys Leu Cys Pro  Asp Gly Val Phe Lys  Asn Thr Asn 
    1625                 1630                 1635             


Thr Val  Glu Asp Gln Lys Asp  Leu Gln His Thr Pro  Arg Lys Glu 
    1640                 1645                 1650             


Gln Ala  Pro Val Gln Val Ser  Gly Ile Lys Ser Thr  Lys Glu Asp 
    1655                 1660                 1665             


Trp Leu  Lys Cys Val Thr Glu  Glu Lys Arg Met Pro  Glu Ala Asn 
    1670                 1675                 1680             


Gln Glu  Ile Asp Asp Asn Val  Leu Ala Asn Ser Arg  Leu Ser Lys 
    1685                 1690                 1695             


Arg Asn  Cys Ser Ala Asp Gly  Phe Glu Ile Leu Gln  Asn Pro Val 
    1700                 1705                 1710             


Lys Asp  Ser Lys Ala Met Phe  Gln Thr Tyr Lys Lys  Leu Tyr Met 
    1715                 1720                 1725             


Glu Lys  Arg Ser Arg Ser Leu  Gly Ser Ser Pro Leu  Glu 
    1730                 1735                 1740     


<210>  16
<211>  1746
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Asn Trp Asn Ala Lys Pro Glu Ser Val Thr Leu Pro Pro Gln Tyr 
1               5                   10                  15      


Pro Arg Lys Gln Thr Ser Phe Leu Glu Gln Ala Leu Val Ser Thr Leu 
            20                  25                  30          


Thr Thr Ser Gln Ser Pro Leu Asn His Pro Gly Ser Asn Gln Glu Ala 
        35                  40                  45              


Cys Leu Phe Leu Ser Asn Ser Asn Pro Val Ser Gln Pro Leu Leu Asn 
    50                  55                  60                  


Asn Arg Asn Tyr Lys Thr Pro Gln Gln Ile Pro Ile Ser Asp Met His 
65                  70                  75                  80  


Ser Gly Thr Ile Val Thr Ser Gln Thr Ser Val Glu Arg Ile Thr Tyr 
                85                  90                  95      


Thr Asn Val Lys Gly Pro Lys Gln Leu Asn Gln Asp Leu Gln Val Ser 
            100                 105                 110         


Ser Gly Val Thr Gln Asp Met Trp Leu Asn Ser Pro Met Arg Asn Ser 
        115                 120                 125             


Met Leu Ser His Thr Gly Ala Thr Val Ser His Gln Thr Gly Phe Gly 
    130                 135                 140                 


Thr Asn Pro Pro Asn Val His Ala Leu Gln Asn Gln Phe Val Thr Ser 
145                 150                 155                 160 


Asp Thr Tyr Ser Met Gln Leu Gln Met Met Pro Ser Asn Ser Gly Arg 
                165                 170                 175     


Ala Pro Ile Thr Tyr Gln Asp Asn Pro Arg Leu Asn Pro Pro Leu Ser 
            180                 185                 190         


Glu Gln Gln Val Asp Trp Pro Gln Gln Cys Ala Ser Ser Gly Leu Ala 
        195                 200                 205             


Tyr Pro Asn Tyr Arg Pro Leu Pro Lys Gln Tyr Gly Tyr Ser Ser Arg 
    210                 215                 220                 


Ser Phe Val Gln Gly Pro Thr Leu Pro Lys Gln Asn Thr Met Ser Ala 
225                 230                 235                 240 


Gly Ser Leu Gln Val Lys Asn Ser Pro Ser Pro Asn Pro Val Leu Pro 
                245                 250                 255     


Leu Gln Ser Lys Gln Ile Ala Thr Ile Pro Ser Tyr Gln Tyr Ala Val 
            260                 265                 270         


Thr His Thr Asp Glu Arg Pro Pro Pro Pro Tyr Asp Cys Arg Tyr Ala 
        275                 280                 285             


Ser Gln Pro Leu Gln Ser Ile Gln His Val Val Lys Arg Ser Ser Met 
    290                 295                 300                 


Asp Gly Pro Gln Thr Gln Glu Met Tyr Leu Pro Glu Met Gly Lys Asp 
305                 310                 315                 320 


Phe Cys Arg Gly Phe Gln Gln Gln Trp Gln Asn Ser Asn Glu Asn Phe 
                325                 330                 335     


Ser Met Met Gly Asn Thr Cys Asn Leu Lys Val Asn Thr Asn Val Gly 
            340                 345                 350         


Gln Pro Phe Asn Arg Pro Val Arg Ser Ser Leu Asp Ser Val Gln Ala 
        355                 360                 365             


Leu Gly Gln Asn Thr Gln Glu Lys Arg Val Asp Ser Gly Asn Leu Thr 
    370                 375                 380                 


Ser Asn Gln Val Leu Asp Thr Arg Ala Lys Lys Lys Lys Leu Val Arg 
385                 390                 395                 400 


Asp Ile Lys Thr Leu Val Glu Ile Lys Lys Lys Phe Ser Asp Leu Ala 
                405                 410                 415     


Arg Lys Ile Lys Ile Asn Lys Ser Leu Leu Met Ala Ala Gly Cys Ile 
            420                 425                 430         


Lys Thr Thr Ser Ser Pro Tyr Ser Asn Thr Ala Gln Asn Ser Gln Phe 
        435                 440                 445             


Ser Leu Lys Gln Thr Ala Lys Val Gln Cys Gly Pro Gln Val Thr Ile 
    450                 455                 460                 


Val Thr Pro Glu Thr Met Glu Asn Lys Ser Pro Ile Val Met Glu Ser 
465                 470                 475                 480 


Ser Glu Val Ala Asn Lys Thr His Ser Pro Ser Asn Ser Asn Leu Gln 
                485                 490                 495     


Asp Arg His Phe Asn Gln Val Ser Ser Val Leu Leu Asn Ser Val Pro 
            500                 505                 510         


Ser Glu Lys Leu Pro Ile Pro Glu Gln Leu Arg Asp Leu Lys Val Val 
        515                 520                 525             


Thr Ser Ser Lys Met Ser Thr Val Glu Ile Pro His Ala Thr Ser Asn 
    530                 535                 540                 


Asn Ile Gln Phe Ser Ser Gly Asn Leu Val Asn Ser Thr Lys Asn Val 
545                 550                 555                 560 


Pro Ala His Ser Glu Thr Thr Pro Leu Pro Gln Phe Met Thr Phe Glu 
                565                 570                 575     


Glu Tyr Ile Ser Lys His Pro Asn Lys Asn Arg Leu Val Leu Ser Leu 
            580                 585                 590         


Leu Ala Pro Gly Gly Lys Ile Glu Arg Lys Leu Leu Lys Asp Thr Ile 
        595                 600                 605             


Glu Thr Val Lys Asp Ser Lys Met Arg Ser Ser Asp Val Asn Pro Asn 
    610                 615                 620                 


Thr Thr Asn Thr Gly Asn Leu Met Asn Leu Lys Thr Val Glu Thr Ala 
625                 630                 635                 640 


Ser Ala Cys Asn Ile Asn Ala Lys Ile Ser Asp Asn Ser Ser Gly Phe 
                645                 650                 655     


Glu His Lys Ser Leu Asn Gly Met Ser Ser Lys Ser Asp Ser His Phe 
            660                 665                 670         


Ser Met Glu Leu Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro 
        675                 680                 685             


Ser Glu Pro Thr Val Glu Lys Gln Ser Asn Glu Ser Lys Thr Asn Arg 
    690                 695                 700                 


Ala Ala Ala Gly Val Ser Lys Pro Val Glu Val Cys Glu Thr Ser Pro 
705                 710                 715                 720 


Phe Ser Ala Val Gly Asn Ser Gln Asn Lys Val Thr Ser Ser Ser Gln 
                725                 730                 735     


Glu Thr Val Leu Ser Met Val Thr Gln Asn Phe Glu Ser Ser Gly Ser 
            740                 745                 750         


Thr Thr Thr Lys Gly Ile Ala Val Val Ser Pro Leu Ile Leu Ser Asp 
        755                 760                 765             


Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Glu Ala Leu Pro Glu 
    770                 775                 780                 


Thr Ala Tyr Pro Val Ile Lys Glu Gly Ser Ile Cys Ser Leu Gln Asn 
785                 790                 795                 800 


Lys Leu Glu Asn Thr Ala Ala Leu Lys Val Ser Val His Glu Pro Val 
                805                 810                 815     


Thr Ser Thr Thr Ser Thr Lys Ile Phe Pro Leu Ile Gln Lys Glu Lys 
            820                 825                 830         


Gln Asn Glu Ser Thr Asn Ala Asn Ser Glu Gly Thr Pro Asn Thr Ser 
        835                 840                 845             


Gln Gly Lys Tyr Asn Glu Thr Glu Pro Asp Val Gln Cys Pro Val Ser 
    850                 855                 860                 


Asp Gln Gln Thr Ser Tyr Val Ser Lys Asp Ser Asp Asp Val His Ser 
865                 870                 875                 880 


Asp Val Leu Gln Ile Asp Asn Ile Cys Ser Leu Val Glu Gly Asp Thr 
                885                 890                 895     


Ser Tyr Asn Ser Gln Ile Ala Lys Ile Phe Asn Leu His Pro Leu Glu 
            900                 905                 910         


Lys Val Glu Gln Gln Lys Pro Leu Leu Ser His Gln Val Met Ser Ser 
        915                 920                 925             


Arg Gln Gln Asn Glu Gln Val Asp Val Thr Glu Ser Lys Asp Phe Asp 
    930                 935                 940                 


Cys Gln Lys Asp Asn Phe Val Gln Cys Thr Asp Thr Ser His Glu Thr 
945                 950                 955                 960 


Ile Asp Gln Ser Met Leu Leu His Pro Pro Glu Ser Ser Ser Leu Lys 
                965                 970                 975     


Tyr Thr Glu Ala Lys Arg Gly Ile Pro Glu Glu Ser Ser Leu Glu Gln 
            980                 985                 990         


Ile Thr Glu Ile Glu Ser Leu Ala  Asp Asp Val Val Ser  Pro Ala Ala 
        995                 1000                 1005             


Ile Gln  Gln Asp Asn Cys Pro  Gln Glu Thr Asp Met  Ser Cys Ser 
    1010                 1015                 1020             


Tyr Thr  Ala Gln Asp Pro Thr  Lys Asn Glu Leu Leu  Asp Asp Glu 
    1025                 1030                 1035             


Thr Ser  Ile Leu Tyr Leu Gln  Asp Gln Leu Ser Glu  Leu Leu Lys 
    1040                 1045                 1050             


Glu Phe  Pro Tyr Gly Ile Glu  Pro Val Asn Met His  Glu Gly Cys 
    1055                 1060                 1065             


Ala Val  Gln Gln Met Ala Asp  Pro Ile Ser Lys Pro  Gln Thr Cys 
    1070                 1075                 1080             


Glu His  Thr Gly Cys Asp Ser  Lys Asp Ser Thr Asp  Gln Ile Gln 
    1085                 1090                 1095             


Ile Thr  Ile Leu Asn Ser Glu  Gln Met Lys Glu Leu  Phe Pro Glu 
    1100                 1105                 1110             


Gln Asp  Gly Pro Pro Asn Glu  Val Asp Arg Leu Thr  Glu Leu Gln 
    1115                 1120                 1125             


Glu Glu  Lys Pro Val Thr Lys  Glu Gly Asn Gln Cys  Asp Pro Gln 
    1130                 1135                 1140             


Ala Arg  Thr Ile Glu Glu Ser  Cys Glu Ser Val Val  Leu Asp Ser 
    1145                 1150                 1155             


Glu Lys  Asp Asp Val Arg Cys  Cys Ala Leu Gly Trp  Leu Ser Met 
    1160                 1165                 1170             


Val Tyr  Glu Gly Val Pro Gln  Cys Gln Cys Asn Ser  Ile Lys Asn 
    1175                 1180                 1185             


Ser Ala  Ser Lys Glu Glu Lys  Gly Lys Asp Pro Cys  Ser Leu Glu 
    1190                 1195                 1200             


Ala Asn  Ala Asn Ser Tyr Lys  Arg Gly Glu Arg Thr  Ser Asp Gly 
    1205                 1210                 1215             


Asp Asp  Ser Val Thr Phe Glu  Asn Pro Pro Asp Asn  Gln Lys Leu 
    1220                 1225                 1230             


Pro Leu  Thr Phe Pro Val Glu  Glu Lys His Phe Pro  Glu Thr Glu 
    1235                 1240                 1245             


Gly Gly  Arg Asn Ile Asn Asp  Lys Ser Glu Thr Glu  Gln Asn Ser 
    1250                 1255                 1260             


Ser Leu  Arg Thr Glu Gln Glu  Leu Pro Gly Gln Phe  Leu Cys Lys 
    1265                 1270                 1275             


Gly Gly  Lys Arg Arg Asp Pro  Leu Gln Arg His Lys  Lys Lys Pro 
    1280                 1285                 1290             


Leu Gln  Phe His Glu Val Thr  Phe Gln Ser Thr Asn  Lys Thr Ile 
    1295                 1300                 1305             


Lys Ile  Cys Gln Glu Ser Leu  Gln Arg Lys Leu Met  Ala Gln Asn 
    1310                 1315                 1320             


Leu Arg  Pro Leu Lys Pro Lys  Met Gly Phe Leu Thr  Ser Lys Asn 
    1325                 1330                 1335             


Lys Asp  Leu His Val Lys Asn  Ala Ser Leu Val Gln  Ser Ile Thr 
    1340                 1345                 1350             


Pro Glu  Lys Arg Lys Leu Lys  Ala Ala Gly Ser Lys  His Lys Val 
    1355                 1360                 1365             


Leu Glu  Lys Arg Lys Leu Asp  Asp Gly Ser Ile His  Asp Ser Glu 
    1370                 1375                 1380             


Val Lys  Lys Lys Lys Tyr Asp  Lys Gln Glu Gln Asn  Lys Asn Val 
    1385                 1390                 1395             


Gly Ser  Gly Thr Phe Lys Leu  Tyr Asn Phe Ser Thr  Pro Ser Glu 
    1400                 1405                 1410             


Arg Ala  Met Thr Lys Glu Lys  Thr Val Ser Asn Val  Lys Ser Ser 
    1415                 1420                 1425             


Gly Ser  Lys Asp Gly Ser Ser  Lys Ile Asn Arg Val  Leu Thr Ala 
    1430                 1435                 1440             


Lys Glu  Tyr Leu Ala Arg Gln  Lys His Lys Glu Ala  Val Ser Gly 
    1445                 1450                 1455             


Lys Thr  Leu Lys Lys Asn Cys  Leu Lys Asn Leu Pro  Cys Asp Ser 
    1460                 1465                 1470             


Gln Tyr  Lys Lys Ser Ser Lys  Leu Pro Val Arg Val  Gly Ser Cys 
    1475                 1480                 1485             


Gly Lys  Ser Ser Glu Arg Gln  Asn Ser Asn Val Gln  Thr Thr Lys 
    1490                 1495                 1500             


Glu Ser  Leu Pro Ile Ser Ser  Asn His Gly Lys Ser  Leu Lys Ile 
    1505                 1510                 1515             


His His  Ser Arg Asp Ser Lys  Thr His Ile Leu Arg  Asn Ile Lys 
    1520                 1525                 1530             


Gly Thr  Val Gly Gly Lys Gln  Pro Asp Lys Met Trp  Ile Asp Lys 
    1535                 1540                 1545             


Thr Lys  Ser Asp Lys Asn Val  Asn Asn Val Asn Asn  Glu Ala Glu 
    1550                 1555                 1560             


Phe Ser  Gln Met Ser Ser Gln  Ala Lys Asp Gln Arg  Lys Thr Tyr 
    1565                 1570                 1575             


Leu Asn  Arg Val Gly Phe Lys  Cys Thr Glu Arg Glu  Arg Ile Cys 
    1580                 1585                 1590             


Leu Thr  Lys Leu Asp Gly Ser  Pro Arg Lys Leu Asn  Lys Glu Lys 
    1595                 1600                 1605             


Arg Pro  Glu Asn Lys Pro Lys  Asn His Val Pro Gly  Lys Asp Thr 
    1610                 1615                 1620             


Ser Glu  Lys Leu Ser Met Leu  Glu Phe Lys Leu Cys  Pro Asp Gly 
    1625                 1630                 1635             


Leu Phe  Lys Asn Pro Asn Pro  Val Glu Asp Gln Lys  Asp Leu Gln 
    1640                 1645                 1650             


Pro Cys  Pro Met Lys Glu Gln  Ala Pro Val Gln Val  Ser Gly Ile 
    1655                 1660                 1665             


Lys Ser  Thr Lys Glu Asp Trp  Leu Lys Cys Val Thr  Glu Glu Lys 
    1670                 1675                 1680             


Lys Ile  Pro Glu Pro Asn Gln  Glu Ile Asp Asp Val  Leu Ala Asn 
    1685                 1690                 1695             


Ser Arg  Leu Ser Lys Arg Ser  Phe Ser Ala Asp Gly  Tyr Glu Thr 
    1700                 1705                 1710             


Gln Gln  Asn Gln Val Lys Asp  Ser Lys Ala Met Phe  Gln Thr Tyr 
    1715                 1720                 1725             


Lys Lys  Met Tyr Met Glu Lys  Arg Ser Arg Ser Leu  Gly Ser Ser 
    1730                 1735                 1740             


Pro Leu  Glu 
    1745     


<210>  17
<211>  4644
<212>  DNA
<213>  Cricetulus griseus

<400>  17
atgaattgga atgcaaaacc agagaatgct gccccaaacc caccatattc taaaagccag       60

tcgtctcttt tgcagcagtt tttaatgcct tccacaactt ctcaaagttc tttcagctgt      120

ctcccacata accaagaagc atgcatatat cccactaatt caaattcagt ttcacagcca      180

cttctgaacg tcaggagttt cataaatcct ccgatctctg tttctaatgt gcataatagg      240

acagttgtgg cctcacagac ctcagtagaa agagtcacat atacaaatgt taaaggagcc      300

caacaaccaa accacaattt gcaaacagtg tcttctggag ttgtgcaaaa tgcctggatg      360

aattcaacaa tgaggaattt tatgccttct cttacagagg caaccatatc tcataaacct      420

gatggtgggc ctagtatgcc atatatgcat gcaccacaga gtcatcttgt cacatcagac      480

acctactctg tgcaactaca gatgactcct tcaaactctg taagaggccc tgtaacttac      540

caaggaaatt atcaaggaaa tccgggactt aaccactcga tggcaggtga gcttggctgg      600

gtacaatgtg catccagtga acttacttat ccagattaca gaccacctcc aaagcaatat      660

ccttatttac cacaaagctt tgtgcaagac acttctgttc agaaacaaaa ctttgtgtca      720

tctacatcat tacaagttaa aaataatcag cttccacctt ctacacagac cttaccatca      780

aagcgccctg tacctgtgtc gtcatatcag tatgctgcag aaaccagcaa aagactccct      840

cccccccctt acagctgtag atatggaagc caacatgtgc aaaattctca gtctgtttct      900

agacacttgc ctgtggaagt tcctcagagt tcagaaatgc actcgtctga aaaaaagaaa      960

gatgcttaca aagtctttca acagcagtgg cagagcacta gtaaaaatgt cagtacaata     1020

ggaaaattct gtgagttgaa aattaataca aaacagtctt acaatgactc tgctggctct     1080

tctggggatg gtgttcatac tcttgttcaa aataatcaag aagaaagaaa gtattcttat     1140

aatccaagta caaatcaaat actagacaca aatgtcacaa aagaaaagct ggtgagggat     1200

attaaatcac tagtagaaat taaaaagaaa ttttcagaac ttgcaagaaa aattaaaatc     1260

aacaaaaagc ttttgatggc agctggttgc agtaaaacag ctaatacttc ttatactgaa     1320

ccaactcggc attctgaatt ttcagcaaaa gaaatgtctg ctaaaaggga caatcagtgc     1380

tccatggaat tgctagcaac atgcctttct ctttggaaaa accaacctcc aaaaaccaca     1440

gaagaaaatg tttcaaaacc tttagaagaa aaacaatata atgcatcaag aactagtaca     1500

acagcggttg gcccttcaaa tcccatgaat gaagttcatg tgaagaattt ttgttcaggt     1560

gttagaaatt ctcagaaaat aaccacctcg tcacaaacag tcttgtcagt tctcacacca     1620

gtttacgatt cttcagatgt agctgttgga aaaggaacag agcttcagat tgctgtggtt     1680

tcacctttaa ttctttcaga tgtcagtact gtacctggga aagagttagc tcctgaagtc     1740

gtatctgaaa ctgtatatcc agttgtgaag gaaggcagtg tttgtagctt acaaaaccag     1800

caggcagaaa atgcaacagt aactgctggt ttgccctttg atgttatcag agcagtagca     1860

agtgctactg tatcagctga gctatcactg cctgggcata aagaaaagca gcacaaacca     1920

acacagagtg atctagacat cgctgatggc agcctaggga aacactctcc ccagggtgct     1980

gaagctttgc ctaaccctag ggacagcacc attgtgagtg ggcctatatt acagattgaa     2040

agtatctgtt ctcttgcaga aggtgatgta tcttacaatt cccaaatagc agagatattc     2100

aactctgtac aaaatgagcc ccagaaacct tcacctgatc agcaagtaat taatagtcaa     2160

caagaagaac aagtagataa ggttgctgaa aataaagact taagttttct gaaagacaag     2220

tgtatgcagt gtacagatgt tcctcatgaa gtcactgaac agccagagcc actgcagcct     2280

ttagagacaa catctgatga gtatgttgaa gcaaacggag aaatcctaga ggaaagcagt     2340

aaggagaatc ctggtgaaaa agagatgact aaggacatat tgtgttcacc agctgctgtt     2400

cagcaagatc ctcaacctca ggaaattgac acagccagca gtaagtcagg acacagtttt     2460

tctacagtaa atgagattaa tgatgaaaat gaacctgtct catacctaca tgaccagctg     2520

ttagaacttc taaaagagtt tccttatggc attgaaacta ttgccaggcc tgaagtttat     2580

gtgggccaac aaaagacaca tgaaatctta gaaaatcaaa ctggtagtaa aactggtaat     2640

gtgtctgggg ataacacaga ccaaataaaa attacagtat taaactcaga acaaatcaaa     2700

gaattatttc ctgaagagga tcagccatgt gatgtagaca aattggcaga acccgagaat     2760

acaaaaatca ttgcagaagt aaagagcctg tgtgattcac aggtccccag agaagaaagt     2820

cacaaccctg gaatgttgga tctggagaaa gataaaatcc attgctgtgc cttgggctgg     2880

ctctcaatgg tttatgaagg tgtgccacag tgtcagtgca gttccatgga agagaaagag     2940

aaagaccagt gttctttgga aatctctaat tgcaaacaag gagagcaggc ctgcaatagt     3000

ggaatcacta tttttgaaat taatcctatt tctaataact caaaaagtcc tctgatccaa     3060

gaatctgaga aaggccattt ttctgacata catggtgaaa agataaaaac atctgaaaca     3120

aaaaacagca gctcaccaag ggtagaacag gaattaactg gtcatttttc aatgaaatgt     3180

taccagaaag ataaatctac aacaaaacag gatagctcac tgaaaacaga gcaaaaaata     3240

aaaaatcttt cttctaaatg tgacaaacca aatcccttaa aaagcagtaa aataccaacc     3300

cctgaaacat ttaatgtggt aacttccaac tctgataaaa atatgccagc attttctaaa     3360

caagattctc agggaagcct gcagaagaaa cacctattcc aagactcaga tccagtaaaa     3420

ggacatgtat ggcttttgcc aaataaagat ccacgcagga ggaatacctt tttagtacag     3480

tcagtatcac cagaaaagaa aaagttaaaa ttcaaatcgg gtagctccaa actgaaatat     3540

tttgaaaaaa gaaaaatgga ccatttgctt atctcagatg tggaaataaa aaagaagaaa     3600

tacgaaaaac aagagcagaa caaaaatgct ggaggcacac tcaaattatg tagtactctg     3660

actgaaccaa atgaaagagc ctgtgctaaa gaaaagatag tgacaaattc tgagccctca     3720

gactcaaagg gaagctcctc taagagtact agagttataa ctgtgcagga atatttacag     3780

cggaaaaaag acaaacatgt aataggaaat aatgcctcca aaaacatctg tgtagaaaat     3840

gtgccatgtg actctgaacc catgaagtcc agtaaacatt ctgcatcacc tagtttggga     3900

aaattaattg agggccaggg tgtcagtgca gagactttaa aagaagtaga acataattcc     3960

accagccatg gcaaaaatct caagacccac cgttctgagg agactaggcc atacagtgtg     4020

tcaaatagta aagagaaatt ttataggaca catccagaca aatcttacat tgataaagct     4080

aaattagaaa gattgaccag tatgagtagt aagtccagcc agctccaggt aaaggaaaaa     4140

aggaaacagt acctgaatcg agttgcattc aaatgcacag aacaggaaag catttgtctc     4200

accaaattgg acagtgcatc caagaagctt agtaaagaga aagaaaagag tacagcatgt     4260

gcacccatga caaaagacta cacacacaag cccatgttgg agtttaaatt atgtccagat     4320

gtgctattga agaatacaag ctccattgac aaaggggatg atccaaggcc tgggcctgag     4380

aaggagcgag cacctgtgca agtttcagga ataaaaacta caaaagaaga ctggttaaaa     4440

tgtatcccaa caaggacaaa gatgcccgaa tcaagtgaac aaacagatcg ggctgactca     4500

agactctcta agagaagctt cagtgcagat gaatttgaaa ctctacaaaa cccagtaaaa     4560

gactcaaatg tcatgttccg gactttcaaa aagatgtacc tggagaagag aagcaggagc     4620

ctggggagca gtccagtgaa gtag                                            4644


<210>  18
<211>  112
<212>  DNA
<213>  Cricetulus griseus

<400>  18
tgctgggatt taaggggaaa gctttaataa aagatcttta tttgtatttc ttgcagattt       60

gtgacattca aaaccacaga ctatgcaaca ctactactaa accaggtcaa at              112


<210>  19
<211>  36
<212>  DNA
<213>  Cricetulus griseus

<400>  19
cttcgggata gagtggtttt gcttttacca ccagga                                 36


<210>  20
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  20

Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys 
1               5                   10                  15      


His His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys 
            20                  25                  30          


Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu 
        35                  40                  45              


Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys 
    50                  55                  60                  


Gly Glu Met Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys 
65                  70                  75                  80  


Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp 
                85                  90                  95      


Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu 
            100                 105                 110         


Asp Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys 
        115                 120                 125             


Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys 
    130                 135                 140                 


Ala Val Gly Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro 
145                 150                 155                 160 


Thr Val Leu Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn 
                165                 170                 175     


Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala 
            180                 185                 190         


Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
        195                 200                 205 


<210>  21
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ala Met Ser Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu 
1               5                   10                  15      


Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser 
            20                  25          


<210>  22
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  23
<211>  128
<212>  DNA
<213>  Cricetulus griseus

<400>  23
atgtttggtt ttcacaagcc aaagatgtac cgaagtatag agggctgctg tatctgcaga       60

gccaagtcct ccagctctcg gttcacggac agtaaacgtt atgaaaagga cttccagagc      120

tgttttgg                                                               128


<210>  24
<211>  25
<212>  DNA
<213>  Cricetulus griseus

<400>  24
tgtaccgaag tatagagggc tgctg                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Cricetulus griseus

<400>  25
tgtccgtgaa ccgagagctg gagga                                             25


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1

<400>  26
gtcccagcac tcatgaggat                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  27
cctcctagct ccaggtattt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3

<400>  28
gaggacttgg ctctgcagat                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 4

<400>  29
ttccacagag cacagccgat                                                   20


<210>  30
<211>  1080
<212>  DNA
<213>  Cricetulus griseus

<400>  30
ccttagtatt gggattttga ccagggtagt taatttcagt catcatttct aaactctaag       60

gttgtcatat ctgtgatttt cataccttcc taaaggtgac tgtatagaac ttcagttatc      120

aaagaacaca ccccccactt ccacagagca cagccgatat gtggagcctc ttgtgtcctg      180

ggaacagagt ggtcatagtg aatgcacact actttcccag cagggagttt aaagttttag      240

gtacattctt aatggcatgt gtgtatgggg gtgggcacag tagtaaagaa agtgccaaca      300

tgactgactg ctccatgatg tggttaaggt ttttattaga tgaacagcag ccagcaaact      360

gggcatggcc agggttctgt ctcttgagta ttgtggtata gttagttcct atgttgtgtg      420

atataagaaa caaaggaggt agtggatgcc tcctagctcc aggtattttc gaatgttttg      480

tatactggcc ctatggagta gtagatctgg ggaattcttg tagtttgttt gacttggcta      540

taaaattgta tgtgctggag gtagggtgga acagagaaaa gtccttgcat cgtttcttgt      600

catttccctt aacaaagctg tgccaattcc tttgtcttta caggtattgc tcagaagaaa      660

agatgtttgg ttttcacaag ccaaagatgt accgaagtat agagggctgc tgtatctgca      720

gagccaagtc ctccagctct cggttcacgg acagtaaacg ttatgaaaag gacttccaga      780

gctgttttgg gtaagattag ttatggtccc tcccccaccc cattacccct cactctccac      840

cgaggcaggg tttctctgta gcttaagagc ttgtcctgga actggctctg tagaccaggt      900

tagcctcaaa ctcacagaga tcctcatgag tgctgggact aaaggcatgc accaccacca      960

tccacctgta ttccattctt agagggaaaa ataatcagga ttgtgtggaa atgtttccat     1020

gcaaagcaat gggaacaatg tgctaatatt taaaatcact agttttctat tatttgggtt     1080


<210>  31
<211>  114
<212>  DNA
<213>  Cricetulus griseus

<400>  31
atgtttggtt ttcacaagcc aaagatgtac cgaagtatag agggctgctg tatcctccag       60

ctctcggttc acggacagta aacgttatga aaaggacttc cagagctgtt ttgg            114


<210>  32
<211>  123
<212>  DNA
<213>  Cricetulus griseus

<400>  32
atgtttggtt ttcacaagcc aaagatgtac cgaagtatag agggctgctg tatctgccaa       60

gtcctccagc tctcggttca cggacagtaa acgttatgaa aaggacttcc agagctgttt      120

tgg                                                                    123


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - METTL20_1 sense

<400>  33
cccugauguu guuagaggat t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - METTL20_1 antisense

<400>  34
uccucuaaca acaucagggt t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - C12orf35_1 sense

<400>  35
cauccagaca aaucuuacat t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - C12orf35_1 antisense

<400>  36
uguaagauuu gucuggaugt g                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - C12orf35_2 sense

<400>  37
ccagaaagau aaaucuacat t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - C12orf35_2 antisense

<400>  38
uguagauuua ucuuucuggt a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Caprin2_6 sense

<400>  39
ugaccugccc ugaaagaaat t                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Caprin2_6 antisense

<400>  40
uuucuuucag ggcaggucag t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA - FAM60A Sense

<400>  41
gcuuccagcu cuaacagaat t                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA - FAM60A Antisense

<400>  42
uucuguuaga gcuggaagcc a                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_1 sense

<400>  43
gacccgaacu uugacccuat t                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_1 antisense

<400>  44
uagggucaaa guucggguct g                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_2 sense

<400>  45
cggagacucu ucaaauugat t                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_2 antisense

<400>  46
ucaauuugaa gagucuccgg a                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_3 sense

<400>  47
gccugauuga agacgaggat t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - IPO8_3 antisense

<400>  48
uccucgucuu caaucaggct t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Dennd5b_2 sense

<400>  49
gggucucccu uauucaagat t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Dennd5b_2 antisense

<400>  50
ucuugaauaa gggagaccct g                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Amn1_4 sense

<400>  51
gcugcuuaag uauuacugat t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - Amn1_4 antisense

<400>  52
ucaguaauac uuaagcagcc a                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - TMTC1_1 sense

<400>  53
guauaccugu gauaaaacat t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - TMTC1_1 antisense

<400>  54
uguuuuauca cagguauaca t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - TMTC1_2 sense

<400>  55
cggugaaugu cauucuacat t                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA - TMTC1_2 antisense

<400>  56
uguagaauga cauucaccgc a                                                 21


<210>  57
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR20 forward primer

<400>  57
accagtgaat aatcgtgttt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR20 reverse primer

<400>  58
ctatgagtca atgtcccaag                                                   20


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PCR28 forward primer

<400>  59
cacacacaac ctcctaacaa ccc                                               23


<210>  60
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR28 reverse primer

<400>  60
ttccgcaccg actcagttct                                                   20


