                         SEQUENCE LISTING

<110>  BASF SE
 
<120>  GENE CLUSTER FOR BIOSYNTHESIS OF PAMAMYCIN

<130>  PF 76081

<150>  EP 13198688.7
<151>  2013-12-20

<150>  EP 14169265.7
<151>  2014-05-21

<150>  EP 14183171.9
<151>  2014-09-02

<160>  417   

<170>  PatentIn version 3.5

<210>  1
<211>  19895
<212>  DNA
<213>  Streptomyces alboniger


<220>
<221>  gene
<222>  (51)..(281)

<220>
<221>  gene
<222>  (335)..(1369)

<220>
<221>  gene
<222>  (1381)..(2700)

<220>
<221>  gene
<222>  (2912)..(4249)

<220>
<221>  gene
<222>  (4246)..(6108)

<220>
<221>  gene
<222>  (6146)..(7105)

<220>
<221>  gene
<222>  (7158)..(8192)

<220>
<221>  gene
<222>  (8246)..(9040)

<220>
<221>  gene
<222>  (9056)..(10135)

<220>
<221>  gene
<222>  (10152)..(11447)

<220>
<221>  gene
<222>  (11473)..(13017)

<220>
<221>  gene
<222>  (13014)..(13841)

<220>
<221>  gene
<222>  (13838)..(15541)

<220>
<221>  gene
<222>  (15525)..(16508)

<220>
<221>  gene
<222>  (16605)..(17951)

<220>
<221>  gene
<222>  (18000)..(18821)

<220>
<221>  gene
<222>  (19039)..(19845)

<400>  1
gtcgtgccca ggtccgtgcg caccgcgctc tccagggacc tgggcacggc tcaggatgct       60

tgcttgcggc gctcgacgag ttcgacgatc ctgtcgagcc gctccagctc gacgacctcg      120

tcgtcggtga tctccacgcc gaatcccttc tccagggcga gggcgaactc gaccgacgcc      180

agggagtcca ggccgaggtc ctccagcgtg gagtccgggg ctatccggtc ctcggagatc      240

ttgaattcgt tggtgagcag ggacttgacc gattcgtaca ccgtttcctc cgggggacgc      300

tgcgtcggtg ggtgggacgg gcggttggtc cgcctcagcc gcggtacgta tgcacggcca      360

gggccgtgac gtccggccac gtcagagagg ccgcgcccca ggcgagcccg ccgccgaacg      420

ccgcgagcag cacccggtcg ttcgtccgca gcctgcccgc cgcggccgag tcggcgagca      480

gcaggggaag ggacgcggcc gaggtgttgc cgacatgctc gatgttggac aggacgcggt      540

cgcgcgggac gcccagttcg tcggcgacgg cttcgctgat gcgtgcgttg gcctgatggg      600

tcgccagacg gtcgacgtcc tcgaccgtcc agccggagcg ctcgatgacc tcgcgcgccg      660

actgtgccat gcgctccttc gcgtgccggt agaccttgcg gccctgcatc tgtaggtggt      720

gatcgctcgg ctcgggcacg gtccgggcgg cgcgctgccg ggcaccgccc gcggggatct      780

ggatgaggtc gctgtgcgtg ccgtcgctgc cgagccggat cgggccgatg gctcccggct      840

cgtcggggtc accggcgcgc agcacgacgg ctccggcggc gtcgccgaag atgacggccg      900

tgttgcggtc ctgcgggtcg acgatggcgg agaaggtctc ggcgccgatg accaggacgc      960

ggtcggcgaa gcccgcggcg atcgccccga ctcctgccga cagcgcgtac aggaatccgg     1020

cgcagacggc ggcgacgtcg tgcgcggcga cggggccgag cccgagcgcc gccgcgacct     1080

cgggggcggt ggccgggcag aggcggtccg gggtcgccgt cgcgaggacg accgcgtcca     1140

cgtcgtcgcg gccggccgac ttcagggcca gccgccccgc ctccacggcc agttcccgcg     1200

tggccatgcc cggcgggacg gtgtgccgct cggcgatgcc ggtgcggctg cggatccagt     1260

cgtcggtggt gtcgaggcgg gcttccaggt cggcgttggt gaccgtgccg ggcggcaccc     1320

agccggcgac gcccgccagc acggccgcgc gtgtcctgtt gtggtccatg tccgcgggcc     1380

tcacgccttc cccagcagga tcgcgctgct gaccatgccg acggtgtagt tgaaggagag     1440

cgcgtgatcg atgcgcagtg gccgggcggt ggtgcccggc accgggtcga agaggcaggt     1500

gtcgtccggg tcgacgcagc cggccgtcgg gaacaccagg tcgcgctgga tcatcaggga     1560

cgtggccgcc actcccagag cgccgagcgg accgccgttg tgcccgaagc aggcctcctg     1620

cacggtgacg ggcatcgcgg tcgcgcggtc cccgaagagg ctgcgcatga tgttcgactc     1680

cgtctcgtga aagacgcggt cgccctcggc ccctccgttg acgtagtcga tctgttcggc     1740

ctcgacgagg cccgccatgg cgtcccggga ggcctggacc atgccggtcc ccgcacggtc     1800

gatggcgaag gcgctgtgct gcgggctgcg ccgggtgcgc tgcgccagca ttcgggagta     1860

gggggtcgcg ccgcgccgct cggcatgcgc gcggctctcc acgacgagcg tgatggagcc     1920

gttgcccatg ttggagcccg gggagttctt gtcgtacggg cgcatctgcg cgcccatcgc     1980

cagtgcggcg tcctccatgg cgtcgacggt gatgccctcc tcggcgctca gctcggcgta     2040

ccggtcgagg aggtcggcgt agtgccgcag gaagccgagg ccgaacacgt cggcgccggt     2100

gaccaccgcg acctccacct caccgtcggc gatcatccgg cccgccatgc ccaggagcac     2160

cgcggaggac gtacagccgt tggagacggt gaagttgggg ccggtcccgg ccacgaccga     2220

cacctggacg ttggccacgt ccatggggat gccggtcagg gcgagacggg tgcccagttc     2280

gttgatctcg tccttggtgg cttgggtgcg atcggtgttg aggatgtcgg cgtactgcgc     2340

cgaccagcag tcgccgccgt cccgggctgc gaggatcgcc gcttgcgaca gggcgcccga     2400

gcgccagtcg agtccggcgt caccgcacgc ctcggccatg gagatcaggc cgagcaactg     2460

caccggggaa tagagtttca gagcctttac gggaagttcg ggataacgct ccttcacatc     2520

cgcgatatcg gtgcgcactt gaccgaagaa gacgccgtca ttctccacgt agcaggcgcc     2580

ggtggagacg atgtccagga attgcgcgga cgtcgcgcac agtcctcctg ggccgggcag     2640

ggcgaatccc atgcccgtga tcagtgcgtc gcgaccggga tcctgctgct gatgcgccat     2700

gagactccct gtgttgcgtg ccgctgtcga caggccgccg acgctagagc ggtgcgggtc     2760

ggggcgtaac cggctcctgg tacccggttt ccgccaccac aggtatcagt agtactgaaa     2820

tcaataattg gtacttcaag taccacaggg ggattctccc gggtaccggt gggccgatgt     2880

ccctcgaatt cccggcggat agctttcccg tatggctgca caggctgaat ccgctgcacg     2940

gaaaaaccgc ggggactccg tactcgtcac cggtatcggc gtcatgctcc ccggcgcgac     3000

ccatgtcaac gaattctggc aggacgtgcg cgacggcaat tcacgactcg gccggctgac     3060

gcgctgcgta ccgggcagga ccggggtacg cgtggccggc gagctgcgcg acttcgacca     3120

ccggaagttc ctgccggagc tgaacgagaa gttcgcgggc cggtacacgc gcgacgcgct     3180

ggtgaccatg tcggccgtcg aggaggcccg ccgtgacgcg ggtctcgggt ccggcgagat     3240

cgacccgctg cgcctctccc tcatcgcctc gtcctcacgc ggccccctgg agtgggtcag     3300

ccaggcgctg cgggaggacg acagcgtcgg caacagagaa ggccacgaag accacgaggc     3360

gggcagcacg gcccacttcg gtgacagcgg cgccatgctg cgcggcatgc cgggcgcccc     3420

ggcgacgctg tcggccatct acggcgacgt gcgcggactc gtcaccacgc tcagctccgc     3480

ctgcgtgggc gggcaccacg ccatcggctt cgccgccgac ctcattcgcg cgggcaccgc     3540

cgacgccgtg gtcgtggtgg gctacgaatt ccccctgacc cccctggtgt tccagtcctt     3600

ccaggcgatg ggcgaccgcg tcctgtcggc cgagtcggcc gacccccgcc gcgcgatccg     3660

cccctacacc cgcgaccgcg agggcttcgc cttcggcgag ggcgccgtcg ccctgtgcct     3720

ggagcgggag agccatgccc gggcacgcgg cgcgggcggc tacgcccgct tcctgtccca     3780

cagggcgctg aacgaggcaa cccacccctt cggcatggac atgagcgggc agatcaccgc     3840

gtccgccgtc gccggggcgc tccaggacgc gggccgcacc ccgcgggacg tcgactggtt     3900

ctgcgcgcac ggcaccgcca cgccgaagaa cgacgtggcc gagagccgca tgctcggtgc     3960

cctgtacgag ggccgcccgc ggtccgcctg gccgcccctc agctccgtca agccggtgta     4020

cggccacctc ctgggcgccg ccgccctggt caacgcggcg gccacctcgc tggccctgca     4080

ccaccagtgc ctgtgctcga ccgccaacta cgcggacgcc gtgcccgacc cggagtgcga     4140

ccacgaccac gtcgccgagg gggcccgcgc gacccgcacc gaactcgcgg tgtcgctggc     4200

cttcgccatc ggcagccaga cctcggtact ggcactcggc gccgcatgac cggtgccgaa     4260

cccgcgcgga ccgaacccct gaaggagacc atgagcacgc acagcggcac cgcgccacgc     4320

cccgacatcg tccctgacgt cgtccccgac gtcgactccc tggtgtcccg gtacgtgacg     4380

ccggggatgc atctgcacct ggccatgacg atggcgcggc ccaacgccat ggtctacgcg     4440

ctggcacggc ggttcgcggg ccgcggcgag ttcaccgtca gcacgtcggc cacgcacacg     4500

gccatgcacg cgctgaccat gtcgggcgcg gtcaggcatc tgatcacctg cttcctcggt     4560

gacacctacc ccacgccgcg ccccaacccg ctctaccgcg acctggcccg cggcatcccc     4620

ttcacctgcg agttgtggtc cctgctcagc ttcacccagc gcctgatggc cggggccacg     4680

gggctgccgt acgccgtgac gtcctcgctc atcggcagcg atctggagcg cggtctcacc     4740

ggcgacggcc ccgggacacg cccgctgccg gagggcgaac agccgctcgg cggaccgaag     4800

ttcctgcgcc tgcccggccg gtcggccgaa gagcgcccgt tcggtctcgt ggagcggctg     4860

cgtccggacc tcaccctggt gcacggcgcc tgcgcggacc ggcgcggcaa catcgtcctc     4920

gtgccgcccg cgggcgaggg cgcctgggcc gcgtacgccg ccgaacaggg cgtgctcgcc     4980

tcggtggagc gcatcgtgcc cgacgacttc accgacgggc accccgaacg gatcgtcatt     5040

cccggccggc gcgtgctcgc cctgtgcgag gcgccgctgg gcgcgcaccc gcagtcgctg     5100

cgcggtctcg ccaccggcga cgagcgcggc gacgtgagcg ggtaccgcga cgactacgcc     5160

ttcctcaccg agctggtgga ccggctggcc accgaggacg gcgccaagga gtggtaccgc     5220

gagtgggtgg aggagcccgc cgggcacgcg cagtacgtac gcaagctggg cgaggcgcgc     5280

cgcgccgaac tgaccctcgc ctcggggccg ctcacctctc gcgagcccgc cactcccccg     5340

gtgccgctcc ccgcgggagc catcgccgcc gagcccgtga cgcgccagga gcggaccatc     5400

gtcctgggcg cccgcgccat cgccgaccgg gtcacgcgcg acggctacga caccctgctc     5460

gcgggcatcg gcgtctccca cctggccgcc tggctcgccg ccgcgctcct gcgcgaacag     5520

ggcgtgcggg tgccggtctg cgccgagctg ggcttctacg gcatggaccc cgagcccggc     5580

gacgtcttcc tcttcagcca gctgcacgcc acgcgttccc agcagctcgt gggcatcccc     5640

gagatcctcg gcggcatggt gtcggcgaac ccgcgctgcc tgggcgtcct ggccgccggt     5700

gaggtcgacg cggacggcaa cgtcaacacc agcctgctgg ccgacggacg ctggctgacc     5760

ggctccggcg gcgccaacga catcgcgacg agcaccgact gcctggtgct gtccacggct     5820

tccccgcgca agttcgtcga gcgggtcgcc tatgtcacca gtcccggtgc ccgcgtacgg     5880

gaagtggtca gccacttcgg gcggttccgg cgcgagcagg acacacgggg ggccttccgc     5940

ctcgccacct ggctgccgct caacgacggc ccggcctccc ccgaggaggc cgtggcggcg     6000

ctgacccgct ggccggtgag cggcgcgggc tgcacggcgg aaccgcaggt caccgaggcg     6060

gagatcgcct ggctgcgcag tctcgatccg caaggtttct acaggtgacg cgatccgcag     6120

gatcccacca ggtgaggagc acggtgtgag cggtggaatc tgggtgggcc gcggcctgtc     6180

cttccggggc ttcggccact acttcccgcg gcacagcgag gagatcccgg ccgacctgcc     6240

cgacgcgccg gagatggagg cggcggtcct cggcccggac ctcggcgtgg agcggcggca     6300

cctgtccgac gacacggaga gcgtgccgta catggccgtg gaggccggac ggcacgcgtt     6360

gcgcaacgcc ggcctggagg cctgcgacct cgacctggtg gtcttctcct cctggtcgca     6420

gcggcggtac gcgcctgagg acgggccccg gatcgcgatg cgcctcggcg ccgggcgggc     6480

cttggccttc gacgtgtgcg ccgcctgcgt cggcttcgtc cactccgtgc agacggccgc     6540

cgcgatgctg accagtcacc gctggcggca cgccctggtg atctgctccg accagttctc     6600

gcgtcggctc aagcccggtc ggcggggttc gtacgtcggc ggcgacgggg cgggcgcggc     6660

cgttctggag gtgggggcgc cggacgagtc ccggctgcgg gactccgtcg tgctcagcta     6720

cggcgagcac gcgggcgtct ccaaggcccg cggcagcgac ggctggacgg tgagcctgcc     6780

cacgatctcc caggtggccg ccgcgaccgc gggcgaggcc acggacctgg tgctgcggcg     6840

caacgacatg accatcgccg atgtggaccg ggtcgtgccg catccgggct cggcacggat     6900

cagtgaggag ctggtgcggc gcatcggcgt cgcccccgag cgggtcctga cgaacctgcg     6960

gacacgcggc cagacgacca gcgccacgat cccgagcgcc ctgtccgagt tcaccgagtc     7020

cggcgaactg cgcaagggca acgtgatcct gtcgcccgcg gccggcgcgg ggtggttctc     7080

gggcgccctg ctctaccagc tctgacgcac cgacggacag cacacaacga cgggaagacg     7140

aggaaaggac ctcccccatg cccgaaaccc ggtcaccgct cgacggcgga ggcccgccgg     7200

tcgtgctcag tggtgtcggc cactacttcc ccggcgagcc ggtcaccaac gaccacttcg     7260

cccgcctgcc cgagctggac gtggacgacg cctggatacg cgcgtacacg ggcgtgcgga     7320

cccgtcactg ggccggcccc gaggaacggt tcgccgagat gggcgtcaag gcggcccggc     7380

gcgctctcga cgacgcgggc ctcgacatct ccgacgtgga cgtgatcgtc ggcaccagcg     7440

cgaccgcccg gccacgtgcc aacccctcct ccctcggcaa caactacatg gacatctccc     7500

tgccggtgca gcggcagctg ggcgcccgtg acgcgttctg cttcgacgtg accgcggtcg     7560

cctgcgcagg attcctgtac gcgagcgtgg tggcccgcgg gctgctggcg acgacggggg     7620

cccggaccgc cctcgtcgtg tgcgcggaaa gcccgcacgc catcctcaac ttcgggttca     7680

agaactccgc gctcttcggc gcgggcgcgg cggccgcggt gtggcggcgc ggcgagtcct     7740

cgggcggcgg cgccgacggc ctgccgacgc gcagcggcat gatcgacgtc gtcctgcgcg     7800

ccgacggccg ctactacgac gccttcgaca tcgacgagaa cgacaagatg gtgatgcgcg     7860

gcggggtgct ctccgaggtc acgcccgaca tgctcgtcga cgccggagag acggtcctca     7920

agcgcaacgg cctggcaccg gaacagattt cctggtgcat tccgcatcag gcgaacacca     7980

acctcctgta tccgatggcg gaccgcctcg gaattccgcg cgagcggatg ctcctgaatc     8040

ttccgcgccg cggcaacaca tcgagtgtgg gaatgccgag cgcgctctcc gaatacgtcg     8100

gtgacggcac ggtgaaaccc ggcgaactac tcctgggcgt aagcatcggg cgcggcctga     8160

gctggggcgc catggttttc cggtaccagt gaacggccgt accgccgcgg cgcacgcgac     8220

aaccgagagc gagaggtgaa cggccatgtc cgattccagg aatgcgctgg tgaccggggg     8280

aacccgcggc ctcggcctgg ccgtcgcccg gctgctggtg gcgcggggat ggcgcaccac     8340

ggtcctcggc ctcgacccgg gacgcctgga gaaggtgcgg gccatggccg aggccgaggg     8400

cctggacctg cgcgcggtgc gggccgatgt cacctcggag gagtcggtgc gggaggtgtt     8460

cgccgacctg acccggagcg agccgctgca cctgtgcgtg aacaacgcgg gccgcaacct     8520

ctcccgtctg ctactgcgcg aaccgcggga gggcagcggc gccgagctgc tcacgcatcc     8580

gctcgacgac tgggagcaga cgctgcggct gtgcctgacg ggggtcttcc tcgtcggccg     8640

cgaggccgcc gccggcatgg tgcggcacgg ggtgcccggc gccatcgtca acgtctcctc     8700

cggtctcgcg gcgggcgcct acgggcagtc cgcgtacacc gccgcgaagg cgggcgtgga     8760

ggcgctgacc cgtacctggt cctatgaact cggcccctac gggatcaggg tggcggcggt     8820

cgcgccgggc gtgatggacg gtgaggcact gcgcgagaag agcacggcct ttccacggca     8880

cgcccgttat atggacgggc tgaagcgttt tgtcccgctg ggccgttggg ggacggagga     8940

agagatagcg gacgcggtgt gcttcgccgc ggaaaacccc tatatcaccg gatcggtcat     9000

tcgggtcgac ggcggcgggc cgcccggctg ggttccgtaa cgacgccacc cgtgggtgaa     9060

ctacggcttt ttcgcggggt acttcgagta cccgcggcat gaatcatcga gtactggagg     9120

ccagatgcag ccgaatgccg acgccactag tttttcgtcc atgaccacag gcctgcacgg     9180

aatctgggaa gacgccggaa tacgtttcac cggattcggc cactatttcg gctccgagga     9240

aatacacaac cacggcgtcg agaacgcgac gacgagccac gtggaggacc gcgtcatcgg     9300

cggggtcggt gtccgcaccc gctaccgggc caacgacgac gagacccccg tgttcatggc     9360

cgcgcaggcc tcccggcagg cgctggagca ggccggggtc gacgccgacg acatcgatgt     9420

gatggtcgtc agccattgga cggaccgcaa ctacgtgcac gaggtgggcg cgctcaccgc     9480

ggcggagctg ggaatgaagg gctccatggc cttcgaggtg tgcggctcct gcgccggttt     9540

catccaggcg gtgcacaccg cggcgtcgtt cctgaccgcc ccgaccggct accgcaaggc     9600

gctggtggcc accaccgagc gggtcacgcg gcgggtgcgg cccggctcca agggctcaat     9660

gctcgtctcg gacggcgccg gcgcgtgtgt cctcgaagcc acccccggcg gctcccccgg     9720

gctcatcgac tccgtgttcc acaccgacgg cagcctcgcc cacatgtccg cggcgagcgg     9780

ggacaaggga tgggtgaaga gccacccgga cctcaacgac gtcgccctgg cccacatcag     9840

cgacaccgtg gaggagatcc tcggccgcaa caaactggcg atcggcgaca tcgactggct     9900

catcccccac tcggggaccg agccgctggc caagggcatc cagcacaacc tgggagcgga     9960

cccggcgcgc gtcctgacca acctcgcctt ccgcggcaac gtctccagcg cctccatccc    10020

caccaccgtc tcggaactgc gggagcgcgg cgtcgtcaaa cccggcgacc tggtgctctc    10080

cccctccatc ggcggcggcg tctggtgctg gggcagcctc ctgtaccgga tctgagcgaa    10140

gggccaatgc ggtgaccacg accaagggcc cccgggacgc actcgtcacc ggcatgggct    10200

tctgtctgcc ggggcgtacg gcgccgacgg cgacacccga gcagttctgg acggccgtcg    10260

cgcacggcga ctccttcctc gcgcaggacg acggcaccta cttcggcagc gtccccctag    10320

acccggactc cgtcgccgct cgactgccgg agatcccgcc gcgcttcgtc gagaagtact    10380

ccgacatcca tctgtacggg ctgctcgccc tcctggaggc gtgcgaggac gccgcgctcg    10440

actggcgttc gggcgcactg ggcgaggccg ccgtactcgc gggccgcaac gccacggccg    10500

acgccatcgt cgacacgtat ctgccggtgc tcctcgccga cacccggaac atcagcccgc    10560

gcgaggcccg ctcgatactg ttccgcaacg ttctcaacgc ggtgatgtcg gacgtcgaga    10620

cgacccaggc gggcctcgtc ggcgccaccg gccccagcta cacgctgtcc tgcgggtgcg    10680

cctcctcgtc cgtgctgctc ggcaacgcgg cccgcatgat cgcagcgggc gagacggaca    10740

tcgcggtggt caccggcgcc gactactggc gcgagagcag actgcggcag tacgcggacc    10800

tcgaggcacg ctcggtgacc gggagcgaac cgcagaccgc caccctcgtc gacgagccca    10860

tgcgccccta cgaccagcgg gccgccggcc tcaactacgg caacggcgcg gccaccttga    10920

tcctggagag ccgcgagcac gcgcggcgca ggggcgccag gacctacgga cggctcctgg    10980

gccagaccac cacccgcaac gcccagccca acctcgccct cgacgtcgag ggcacggggg    11040

cggtgcgcgc cgcgcgctcc tgcatggccg ggatcgcatc gccggacgag atcgactacg    11100

tcaacggcgc cgcgaccggc gaccgggcgt tcaacctcat ggaaggcaac atcatgcccg    11160

ccatcttcgg tgagcgggcg gcccggctgc ccgtcaccgt ccaggaggcc gtgttcggac    11220

acagcggggc cccgctcgga gtgatcggtg tggcggcgac gctccagatg atgggccacg    11280

gccacatcgc cccgaccgcg aactgcgaga agcccgccga cgtgtgcacc ttcgacccgg    11340

tgcccggcac ccaggggcgg cccgcgcgca tcgacctggc cctcagtctc aactacacga    11400

tcggctccgt ggccagcgcc attctcctgg gaggcaccga tgactgagca cacgccgccc    11460

ggcgccgggc ccgtgctcga aacgggctcc ctggcgcccg tcggccgccg cgtcctgctg    11520

gagtccccgc ccggcgccga ccacacgcgg gcggtccggg aggtctggga gcgacacggc    11580

ttccacgtca cgcacgacga gagcgcgcac atgacccagc ccccggacgt gtactgcgtc    11640

gtggccatcg gcaacgaagc actcggcgcc cggccctcac ctccgttgcg ccgcccccac    11700

gtggcccggg tcctgaaggc catggcccga cggggcgagg gccgcgccgt cctggtcacc    11760

gacacgggcc cgcacgtcca cgacgacgcg gagcccgagg ccgccgcaca gcgggccgcc    11820

gaccacgcgt ggtggcagca cctggccaag cactgcgcga gccggggcgt gctcgccaac    11880

acggtgcgcg tcggctacac cccgttcctc gggcacgagc tgaccgacga ggcggcgggt    11940

gaactgctgc gccacctggt cacccgccgc cccgtcgcac cggaggaact ggcggcggca    12000

ctgcggctgc tggcctcgcg cggcttcggc aacgtcgcgg gcgagacgct gccgctggac    12060

ggcggactcg acgcgagcat cgtgcccatg ccttcggcac gcccaccgcg aatggacgcg    12120

tccgccgccg aaggtgacgg cgccgcggtg cccgacccgt tccggctgac cggacgtgtg    12180

gtcctggtca ccggcgccag cagcgggatc ggggcgagta tcgctcggga gtgcgcggca    12240

cgcggcgccg atgtcgtcct ggccgcgcgc cgccgcccgg agctggagaa gctcgccgcc    12300

gaggtccgcg aactgggccg cacggcctgg gtgttgaccg ccgacctgtc ggatccggcg    12360

cgggccgccg acctcgtgca cgaggcgtgg gagcgtgccg gaggcgtcga cgcgctcgcc    12420

tacggcgcgg gcgccgtctc cttcgacggc tccggtgaca actccgccaa ccgacagcag    12480

ttgctggccc tcaactcgct gtcgtacgcg ggtatgtgtg acgcgctgct cgaacactgg    12540

gtggctgcgg gccgaagcgg ggccgtggcc gccgtctcct cgctggccgc ggtgagcgcg    12600

ccggtggcga acctggcgag ctacgggctc agcaaggcgg cgaccgcgca gttcaccacc    12660

cacttcgcga cctcggcggc ccggcacaag gtgcgggcca acagcgtgct tccgggtttc    12720

gtccgcaccc cgatgacgga cgtcaccaac cccgcgttcc tggaggccac caaccggctc    12780

gtgccgaccg gccggatgag cgaggcgaca gaggtcgcgg cgctcgtctg ctacctgatc    12840

agccccgccg ctgccgggct gaccggcacc cagctgcgcg tcgacggcgg cggtcactgc    12900

ctggccggac tgccgaacct ggccccaccc gagcacaccc ttcgaggaag gaacccggct    12960

gtgacgccct gcgtaccacg cccccgcccc gccgtgccgg aaggggacca caggtgaccg    13020

aggacaggcc cctcaagggc aaggtggcgc tggtcgccgg cgcctcgtcc ggcatcgggg    13080

cgagcatcgc ccgcgcgctg gcggcggccg gcgcctctgt cgccctcgtc gcccgccgca    13140

aggaccaact ggcctgcgtc gagcgcgacg tggccgggca cgaggtgccc gccgtcacgc    13200

tcatcgccga cctgtcggcc gacggcgtgc ccaaggagac ggtgaccgcc gccgagcggg    13260

ccctcggccc cgtcgacatc ctggtgaaca acgccgccct ggctcgcacc ggacccatcc    13320

acgacaccaa cccccgccac tggcggcagg ccttccacct caatctggac gtccccttcc    13380

tgctggcccg cacggtgctc cccgggatgc gcgagcgcgg ccacggctgg atcgtcaaca    13440

tcagctcgga gggcagtctc ctacaggccg actggtcggc cccgtactcc atcaccaaac    13500

gcgccctgaa cgcgctgacc gcgcaaatcg acctggagaa ccggcacttg ggggtccgcg    13560

ccatcgccgt gctgcccggc tgggtgcgca cggacctggc gcaggacccc gagtcgctgg    13620

gggtgggtgt cacggatctg ctggacccct cggacatcgc cgatgtcgtg ctgtgggcca    13680

tcacccgccc gcccgctgtc agcatcggcc cgctgatacc ggtacgcccc gtcagcagga    13740

gtgcccagac cttggtcaac tgggagcagt acctgcggac gctgcgccat tacgacgcct    13800

ccggcggtca catggtcgac gtgcccggga tccctgaatg acgggcccca cgacgtcagc    13860

ggccacggcg gcgcgggatc tcgacgtggc ggccgaccgc ctcgtcgaga tcctcccgcc    13920

gggggacgca cgggtaccgg acgccgagca ctgcgtcacg ggcgcgctgc tcgccgcccg    13980

cgccgaggcc catcccgacc gcgtgtacgc cgtcttcgag gacggcaccc actggacgta    14040

cgggcaggcc tacgacgacg cgcgcaccac cgccgccgcc ctgtaccggc tgggcgtgcg    14100

tcagggcgac accgtgctgt gctggctgcc caacggcctg gacgcgctgc gcgtctggta    14160

cggcgtcaat ctcctcggcg ccgtccacgt ccctgtcaac accgcctatc ggggcgcgct    14220

cctggaacac gtactggaca actccggggc ccgggtcctt gtggtgcacg cgctgctcgt    14280

cgagcggctc cagcacatcg gcgacagccg cctccaggag gtcgtcgtcc tcggcggcgg    14340

accggacgcg ccctggccgg acgccctgcc cggtgccccg cgcgtgcacg gtcccgcggc    14400

gctgcggggc ctgccggagg acttcgtccc gcccgagcgg ccggtcgcgc cctgggacac    14460

catggcggtg atctacacct cgggcaccac cggcccgtcc aagggcgtcc tggtctccta    14520

cgtccatcac tactcgacgg tgaccgcgct cctcgacgac gacatcggcg aggacgaccg    14580

gtatctgctc aacctgccgc tgtgccacgg cggcggtacc gaagtcgcct actgcatgct    14640

cctgttcggg ggctcgatcg tcgtcaccga gaacttccgc accggcgagt tctgggacgt    14700

ggtgcgccgc cacggggtga ccatgtgcac cctgctcggc gccatggtcg acttcctgct    14760

cggtctggcc ccccggccgg acgaggccga acacccgctg cgggccgcgt gcgtgatacc    14820

gctgacgcgc caggccctgg acttcggccg ccgcttcggc gtggacgtct acaccgggtt    14880

caacatgtcc gagacctcgg cgccgctggt gtcaccgctc aatccgcagc gcacgggcag    14940

ctgcgggcgg ccgcggccgg gggtgcagtg ccgggtggtc gacgcgaacg gcatcgacgt    15000

acccgacggc agcgtgggcg agctggtgct gcgcgccgac cggccgtggt cgctgttcca    15060

cggctaccac gccatgccgg aggccaccgc gggggcatgg cggcacggct ggttccgcac    15120

cggggacgcc gtggtgcgtg agcccggcgg cgactacttc ttcgtggacc gcatcaagga    15180

cgccatccgg cgccgcggcg agaacgtgtc ctcgatggag gtcgaagccg agttgctgag    15240

ccatcccgcc gtggcgttcg ccgccgccgt ggcggtgccc agcgacttcg ccgaggacga    15300

gatactcgcc gccctcgtgc tccggcccgg ggcccgtttc gaaccggagg agttcatcgg    15360

gtacctgcgg cctcgcatgg cgcacttcat ggtgccgcgc tatctgcgtg tcctgtccga    15420

gcttcccgtg acggacacgg gcaaggtccg caaggagacg ctgcgcgccc agggcgtcac    15480

ccccgacacc tgggaccgcg tggcggccgg gatcgaggtc acccgtgacc gcatccgctg    15540

agccggccgc ccccgcgcac cgtgtcgtcg acgtctgcgc gctgtccctg gaccgcgagt    15600

gctggcggac gtacttccgc gggctcggcg cggtggcgcc ggcgtacctg cgcgccttcg    15660

gccggcacgc gaccgcggtc ttcggcgccg attacccgcg cttccgtgcc cgcctagacg    15720

ccggggacca ggacggtgcc gtcgacctgc tcgtgtcggg tcagcccgaa cgcgtcgact    15780

ccgacgcgct gttgaagacc atggacgaca acggcgtcgt ccaccagatc ctgatgagct    15840

gcggcggcgc caccgccgac ggcgacgacg tcaacagccg ggtcgccgcc gtcgccgcca    15900

aggcgcccga ccggctccgg gcctgggcgg gcattgacct gaccgacccg ggccgtgccg    15960

tcgccgagct ggaacgctgc catcttctcg gtatgcgcgg cttcgcggtg accccgttct    16020

ggcagggcgt cgacccgcgc gacaccgcgt acgacccggt ctaccgcagg gcacgagagc    16080

tgggcatgcc gttgtggctg cacaccgggc accacttctc gcggcacgcg gccgagttgt    16140

gccatccccg caacgtcgac tggatcgccc tgcgtcaccc cggcctgccg atcgtcgcgg    16200

ggcacgccgc ctggccctgg acccttgagc tgatctccat cgcccagcgg caccgccacg    16260

tctacctcga catctcctcc caccgaccgc agtggatggc ccgccccgga tcgggctggg    16320

aatccctgct cctgtacggc accacggtgc tgcgcgaccg ggtcctgttc ggctcggcga    16380

cctgggtcaa cgccgatccg gtcgccgcgc tcgcccggca ggtcgccgcc ctggatctcg    16440

gcgacgaggt cacggacctc tggctgtacg gcaacgcggc ccgcctgctc ggactcggcc    16500

ccggctgacg ccggtgcgcg cgccccagca cagaaccagc acgtatccag cagagagcac    16560

gtaatcagca gagagcacct atccagcaga gaaagggacc catcgtgatt gaccccgccg    16620

actacgccct gtggaacagc ggcgtgccgc gcccgtacct caaggcgctg tcccgcgacg    16680

acctgctcac cgagggcgac ggcgtgcgcg tccgtgactc cggtggccgc tggtacctgg    16740

acggccgctc cgggctgtgg aacgtgacgc tcggctacgg caacacccgc gtcaaggagg    16800

ccatcaagca gcaggtggac cggctgccgt tcgccaacag ctacggctac ggacgtcccg    16860

cgcaggtcac cgtggactgc gccgaggccc tcgtccgtca tctgcccgag ggcatcaacc    16920

acgtccggtt cgccagcaac ggggcccagg cggtggagat ggccctccag ctgtcgcgct    16980

tcctgcggct gcgggccggg cagcccgagc gcatggccgt gttcgccatg tgggacggct    17040

tccacgggca ggggccgggc gccggcatgg tgaccggtgt cccctacctg caccaccaga    17100

ccgggccgat gctccccgag gtgcaccacg ctcccggccc gttctcggcg ggcgcgacgc    17160

agggcgtcag cgacatggaa cggctgatca ccgagttcgg ccccgagcgg gtgaccgcgg    17220

tgatcgtgga gcccgtcgtc ggcgagggcg gccacatcct gtcccccgag tacctcggct    17280

ccctgggccg gttctgccgt cagcacgaca tccatctgat cttcgacgag gtcgtcaccg    17340

gcatgggccg ggtcggcgac ttcacccgcg ccggccaact gcccgatgtc acccccgaca    17400

tcatcaccct gggcaagggc atcacctcgg ggtacgtgcc gatgtcggcc gtcgccatcc    17460

acgaccgcct ctacgagcag ctgcacgagc gcaccacggg cgacaccgcg ctcagcgtcg    17520

gctcgaccaa cgacggccac gcggtggccg ctgcggcggc gctcgcggtg atcggggcgc    17580

tcaccgagga cggcgtgctg gagaacgtac gccgccgtga ggctgatctc ctctccgccc    17640

tgggcaagct ccaggcccag caccccgagc tgagggcctt ccgcgctctc ggcctgttct    17700

gcggcctgga gctcggcgag cccggcggtc cgtcgtggtc cccgggcaag gtgaaccagc    17760

tgcgcatgac cttggagagc cgaggcgtgc tcagctccag cctgcgtgtc gtaccgaatc    17820

tgatgctcat gccgccgctg gtcatcaccg aggacgacgt ggcggagata gccgatgcgc    17880

tcgacggcgc gctcaccgat gtgaagtcgg gtcggcgccc cgagtccggg ttcgccaagg    17940

ccatgggatg actcgtcagg gccacgggac ggcaacgcgt tttctccacg tgatggaagg    18000

tgagtgacga catgtccaat gcgcacaccg atcgcaagac cagcaagcag tggcaggaag    18060

aggcggcgga ggagtgggac cggtacgccg acatctggga cagctggacc cccgatgaca    18120

gccgggacga tgccgaggag gccgcggact tcctcgcggg cctcgccaag ggcggcaccg    18180

ccctggagct ggggatcggg acgggccgcg tagccctgcc gctcgcgcag cgcggcgtgc    18240

gggtggccgg tatcgacgcc tcgccgaaga tgctgctgaa gctcaaggag aagccgggcg    18300

gggaccggat cgaggtcttc gagggcaact tcgccgatgt cgacgtcaag gaggactacg    18360

acgtcatctt catcgccctc gccaccctgt tcgtcctgcc cgaccaggac gagcaggccc    18420

gctgcctggc caacagtgcc aagcggctca agccgggcgg gcggctcgtc gtccagaaca    18480

tcgtgccgga catgacgtac taccagcgcg ggcggcagaa cgactacggg atgaccgagc    18540

cgttccgtat ctcgggccgg ctggccgggc acccgcggct cgcctggttc gagatgaacc    18600

acgtcgaccc gacgacgcag atggtcaagc gcacggacgt catcatgagc gagaagggca    18660

accgcatcat cgcggcgacc atgcggttcg tgtggccctc ggagcaggac ctgatggccc    18720

ggctgggcgg cctgacgctg gaggaccgct ggggaggctg gcgcaaggag cccttccact    18780

acgacagcag ggacgcggtg tccgtctacc gcaagcagtg accgtccggc gccggacgtg    18840

accgaggccg ggggcggcga ccagccgctc ccggcctcgg ccgcaccgag cgtgcccgaa    18900

cctgcccgta caggcatcgg gggtactcga acgggccgca ggacgagtac ttccagggcg    18960

taggtagccg gtggaaccgt cactacgctg atggttccga cccccgtcaa gtgcaccgat    19020

tcagggtggg cagaagcaat gagcgaagag ttcgggcagg atcgtccggc cgaagcgggc    19080

agcgggagcg gcacggacgt gctcgtcgag cgccgcggcc ccgtgctcgt gatccaactg    19140

aaccggccgc gcgtacgcaa cgcgctgacc cgcgccatgg ccgaacggct cgccgccgcc    19200

ttcacggaac tggatgcccg agcggagctg cgtctcggcg tcctgaccgg caccccgccg    19260

gcgttctgct ccggcatgga cctcggggcc ttcgcccgcg gggagcgcgc ctccctgccg    19320

gggcgtggct tcggcggtct gacggagcag ccgccgagca agccgctgat cgccgccgtg    19380

gagggtgcgg cggtcggcgg tggtttcgag atggtgctcg cctgcgacat ggtggtggcg    19440

gcggacgacg cggtgttcgg gctgcccgag ctgcgccgag ggctggtggc cgcggccggc    19500

ggactgctgc ggctgccgcg cgcgatcgcg ccggccgtgg cgatggagat ggcactgacc    19560

ggcgaaccga tcgatgcgca gcgggccttc gcgctgggtc ttgtcaaccg tgtggtggcc    19620

ccggggacgg cgctgacggc cgcctgcgag ctggcggaga agatcgccgc gcatgcggac    19680

cacgccgtcc tcgcgagcaa gggggtcctc gctcgggtgc gcgacgggga gttggcggac    19740

gagtaccggt cgcaccgcga gctgctgtcg gggatcctcg actcccccgg cgcgcgggca    19800

ggtgcgcgtg agttcgtccg ggaacgtccg ggcggaccgc gatgacgtgc acggacgggg    19860

accggatggt caaccccggg ccccggtggt caccc                               19895


<210>  2
<211>  23339
<212>  DNA
<213>  Streptomyces alboniger


<220>
<221>  gene
<222>  (18)..(755)

<220>
<221>  gene
<222>  (843)..(2519)

<220>
<221>  gene
<222>  (2616)..(2846)

<220>
<221>  gene
<222>  (2900)..(3934)

<220>
<221>  gene
<222>  (3946)..(5265)

<220>
<221>  gene
<222>  (5477)..(6814)

<220>
<221>  gene
<222>  (6811)..(8673)

<220>
<221>  gene
<222>  (8711)..(9670)

<220>
<221>  gene
<222>  (9723)..(10757)

<220>
<221>  gene
<222>  (10811)..(11605)

<220>
<221>  gene
<222>  (11621)..(12700)

<220>
<221>  gene
<222>  (12717)..(14012)

<220>
<221>  gene
<222>  (14038)..(15582)

<220>
<221>  gene
<222>  (15579)..(16406)

<220>
<221>  gene
<222>  (16403)..(18106)

<220>
<221>  gene
<222>  (18090)..(19073)

<220>
<221>  gene
<222>  (19170)..(20516)

<220>
<221>  gene
<222>  (20565)..(21386)

<220>
<221>  gene
<222>  (21604)..(22410)

<220>
<221>  gene
<222>  (22435)..(23082)

<400>  2
gggggtgtgc cagggcgtca ggagtcctgg gaacgcatct gccccatgcc ggacaccatg       60

cattcgaggc cgtcgtggaa tcgctggccc gtgctgctcg aagcgctgcg cttgacgtag      120

tcggccaggg aagccgggtg ggactgggtc gccatgccga ggtaggggcc gaggcgactc      180

acccactcct cctcgctctc ggcgctctgg cgcgccatcg cctgccagga cgcctcggac      240

aaggcggcgc ccacggtgta gtagtagatc gccgagagcg ctgagtccag ctgcctcggg      300

gagaagtggg cctgctccag gatctcgatg atggcgctgg tgtgcgccag cgcgcggggc      360

cccaccgggg ggtgaccgcc catcagctcg atcatccagg agtgccgcag cagtacctcg      420

aacaaatccg tcgcgcccgc cttgatgtcg tcgcgccagt cccccgtgcc ggaccgggaa      480

ggcgggtcgg ggaacaccgc gtcgatggcc agttccagca ggtcgtcctt ggtcgacacg      540

tgccagtaca acgacatcgg tgccgagttc agcgagtccg cgagctgacg catgcgcagg      600

ttgcggacac ccccctcatc caggagacgc accgccgcct gcacgatctg ttcacggctc      660

agcggctgcc tcgccggccg ctgcttcacc tcgcgcagcc agatcgagcc gggttggcct      720

ttcggtgtgt tttctcgtcc agaagtttca ttcacagccc tatgctaacg cagtctcgta      780

cgacgtacga tagctggtat gacgtacgag accagttgac ggaatcccga aggaggccag      840

tcatggacgg cgtggtgcat gagcagcagg gcgcgggccg cggaggaggt gagggcggtg      900

acgacggcgg cgtccccggg gcgaaaaacc gatgggcggt actgggcgtc ctctcgctga      960

gccttctcgt cgtcgccctc gacctgacgg tgctgaacgt ggccctgccc acgctcagca     1020

ccgaacttcg accctcgtcg gtgcagttgc tgtggatcgt cgacgtctac tcgctcgtcg     1080

tcgccggcct gctcatcagc tgcggcacgc tcggcgaccg cctgggccgc aaacgtttcc     1140

tgtgccttgg cttcatcgtc ttcggcggcg catcggccgc cgcggcctgg gcgagcgggc     1200

ccgcgatgct gatcacggcc cgcgcgctgc tcggaatcgg cgccgcgatc atcatgccgt     1260

cgacgctctc gatcatccgg aacgtgttca ccgaccgcaa ggagcggacg gtggcgctcg     1320

ccgtgtgggc caccatgtcc gcggccggtg ccgcggtcgg gccggtggtc ggcggtgtca     1380

tgatcgagca cttctggtgg ggctcggtct tcctgatcaa cgtgcccatc atggtcctcg     1440

cccttatcgc cgcgctgacc ctggtgccgg agtcccggca tccgaatccg ccgcgctggg     1500

acaccgccgg agccctgctg tccgtcaccg gtctgatctc cctcgtgtac gcgattcagc     1560

acggcggcgc gaagggcctg gaggcgcaga cgatcatcac aggcgtgctc ggcctggtgc     1620

tgctcaccgc cctggtggtg cgagtgctgc gcatccgcga tccgctcttc gacccgaccc     1680

tcttccgcga ccgcgcgttc tccgtggcgg tggtgtccgt ggtcctcgcc atgttcggca     1740

tgggcgggct gatgctgctg ctcacgcagc actggcagtt catcggcggc gcctcgccga     1800

tggagtcggg ccttcagctg ctgccgttgc tcctggccac catgatcggg gccccgatca     1860

tgtccgtcat cgtcccgagg tacgggacgc ggtacgccat gatgatcggc atgggcctga     1920

tcggcgccgc gttcttcgtc ctgatgaacg tcgagcccga caccgagtac tgggtcttcg     1980

ccatcgccct cgcgggcatc ggcgccggcg cgggttgcgc catgacggcc gcgtcggacg     2040

ccatcatgtc gacggccgac gcggataccg cgggtggcgc cgcgggcatc gaggagacct     2100

cctacgaact cggcaacgga ctgagcgtgg cgatcatggg cagcgtggcg tccgcgctct     2160

tccgcaggga gatggacgac cccgtcgccg gggtggaccc caaggccatg gatgccgcgc     2220

gcgaaggcct ccccgacgcc gtcggagtgg ccggtgccct gcccggtgcc gtcggggagg     2280

agttgaagcg gcgagccgac aacgcgttca cggacgcgtt cggggtcacg tcgctgtgca     2340

ccggcgtcat cctcgtggtg gtggcggtcg ccgtcttcct gttcatcccg ccctcggcgg     2400

ggcggatcac cccggcgacc gagggcggcg gtgacgcgcc cgaggacggc gtggatctgg     2460

tgaaacagga atcgagggag tccgccgacg gccgcccaac gcccgtggac cggccctgac     2520

cacaggaagc agccggggcc cgtaacgggc cccggctgtc cggtggtcgt gcccaggtcc     2580

gtgcgcaccg cgctctccag ggacctgggc acggctcagg atgcttgctt gcggcgctcg     2640

acgagttcga cgatcctgtc gagccgctcc agctcgacga cctcgtcgtc ggtgatctcc     2700

acgccgaatc ccttctccag ggcgagggcg aactcgaccg acgccaggga gtccaggccg     2760

aggtcctcca gcgtggagtc cggggctatc cggtcctcgg agatcttgaa ttcgttggtg     2820

agcagggact tgaccgattc gtacaccgtt tcctccgggg gacgctgcgt cggtgggtgg     2880

gacgggcggt tggtccgcct cagccgcggt acgtatgcac ggccagggcc gtgacgtccg     2940

gccacgtcag agaggccgcg ccccaggcga gcccgccgcc gaacgccgcg agcagcaccc     3000

ggtcgttcgt ccgcagcctg cccgccgcgg ccgagtcggc gagcagcagg ggaagggacg     3060

cggccgaggt gttgccgaca tgctcgatgt tggacaggac gcggtcgcgc gggacgccca     3120

gttcgtcggc gacggcttcg ctgatgcgtg cgttggcctg atgggtcgcc agacggtcga     3180

cgtcctcgac cgtccagccg gagcgctcga tgacctcgcg cgccgactgt gccatgcgct     3240

ccttcgcgtg ccggtagacc ttgcggccct gcatctgtag gtggtgatcg ctcggctcgg     3300

gcacggtccg ggcggcgcgc tgccgggcac cgcccgcggg gatctggatg aggtcgctgt     3360

gcgtgccgtc gctgccgagc cggatcgggc cgatggctcc cggctcgtcg gggtcaccgg     3420

cgcgcagcac gacggctccg gcggcgtcgc cgaagatgac ggccgtgttg cggtcctgcg     3480

ggtcgacgat ggcggagaag gtctcggcgc cgatgaccag gacgcggtcg gcgaagcccg     3540

cggcgatcgc cccgactcct gccgacagcg cgtacaggaa tccggcgcag acggcggcga     3600

cgtcgtgcgc ggcgacgggg ccgagcccga gcgccgccgc gacctcgggg gcggtggccg     3660

ggcagaggcg gtccggggtc gccgtcgcga ggacgaccgc gtccacgtcg tcgcggccgg     3720

ccgacttcag ggccagccgc cccgcctcca cggccagttc ccgcgtggcc atgcccggcg     3780

ggacggtgtg ccgctcggcg atgccggtgc ggctgcggat ccagtcgtcg gtggtgtcga     3840

ggcgggcttc caggtcggcg ttggtgaccg tgccgggcgg cacccagccg gcgacgcccg     3900

ccagcacggc cgcgcgtgtc ctgttgtggt ccatgtccgc gggcctcacg ccttccccag     3960

caggatcgcg ctgctgacca tgccgacggt gtagttgaag gagagcgcgt gatcgatgcg     4020

cagtggccgg gcggtggtgc ccggcaccgg gtcgaagagg caggtgtcgt ccgggtcgac     4080

gcagccggcc gtcgggaaca ccaggtcgcg ctggatcatc agggacgtgg ccgccactcc     4140

cagagcgccg agcggaccgc cgttgtgccc gaagcaggcc tcctgcacgg tgacgggcat     4200

cgcggtcgcg cggtccccga agaggctgcg catgatgttc gactccgtct cgtgaaagac     4260

gcggtcgccc tcggcccctc cgttgacgta gtcgatctgt tcggcctcga cgaggcccgc     4320

catggcgtcc cgggaggcct ggaccatgcc ggtccccgca cggtcgatgg cgaaggcgct     4380

gtgctgcggg ctgcgccggg tgcgctgcgc cagcattcgg gagtaggggg tcgcgccgcg     4440

ccgctcggca tgcgcgcggc tctccacgac gagcgtgatg gagccgttgc ccatgttgga     4500

gcccggggag ttcttgtcgt acgggcgcat ctgcgcgccc atcgccagtg cggcgtcctc     4560

catggcgtcg acggtgatgc cctcctcggc gctcagctcg gcgtaccggt cgaggaggtc     4620

ggcgtagtgc cgcaggaagc cgaggccgaa cacgtcggcg ccggtgacca ccgcgacctc     4680

cacctcaccg tcggcgatca tccggcccgc catgcccagg agcaccgcgg aggacgtaca     4740

gccgttggag acggtgaagt tggggccggt cccggccacg accgacacct ggacgttggc     4800

cacgtccatg gggatgccgg tcagggcgag acgggtgccc agttcgttga tctcgtcctt     4860

ggtggcttgg gtgcgatcgg tgttgaggat gtcggcgtac tgcgccgacc agcagtcgcc     4920

gccgtcccgg gctgcgagga tcgccgcttg cgacagggcg cccgagcgcc agtcgagtcc     4980

ggcgtcaccg cacgcctcgg ccatggagat caggccgagc aactgcaccg gggaatagag     5040

tttcagagcc tttacgggaa gttcgggata acgctccttc acatccgcga tatcggtgcg     5100

cacttgaccg aagaagacgc cgtcattctc cacgtagcag gcgccggtgg agacgatgtc     5160

caggaattgc gcggacgtcg cgcacagtcc tcctgggccg ggcagggcga atcccatgcc     5220

cgtgatcagt gcgtcgcgac cgggatcctg ctgctgatgc gccatgagac tccctgtgtt     5280

gcgtgccgct gtcgacaggc cgccgacgct agagcggtgc gggtcggggc gtaaccggct     5340

cctggtaccc ggtttccgcc accacaggta tcagtagtac tgaaatcaat aattggtact     5400

tcaagtacca cagggggatt ctcccgggta ccggtgggcc gatgtccctc gaattcccgg     5460

cggatagctt tcccgtatgg ctgcacaggc tgaatccgct gcacggaaaa accgcgggga     5520

ctccgtactc gtcaccggta tcggcgtcat gctccccggc gcgacccatg tcaacgaatt     5580

ctggcaggac gtgcgcgacg gcaattcacg actcggccgg ctgacgcgct gcgtaccggg     5640

caggaccggg gtacgcgtgg ccggcgagct gcgcgacttc gaccaccgga agttcctgcc     5700

ggagctgaac gagaagttcg cgggccggta cacgcgcgac gcgctggtga ccatgtcggc     5760

cgtcgaggag gcccgccgtg acgcgggtct cgggtccggc gagatcgacc cgctgcgcct     5820

ctccctcatc gcctcgtcct cacgcggccc cctggagtgg gtcagccagg cgctgcggga     5880

ggacgacagc gtcggcaaca gagaaggcca cgaagaccac gaggcgggca gcacggccca     5940

cttcggtgac agcggcgcca tgctgcgcgg catgccgggc gccccggcga cgctgtcggc     6000

catctacggc gacgtgcgcg gactcgtcac cacgctcagc tccgcctgcg tgggcgggca     6060

ccacgccatc ggcttcgccg ccgacctcat tcgcgcgggc accgccgacg ccgtggtcgt     6120

ggtgggctac gaattccccc tgacccccct ggtgttccag tccttccagg cgatgggcga     6180

ccgcgtcctg tcggccgagt cggccgaccc ccgccgcgcg atccgcccct acacccgcga     6240

ccgcgagggc ttcgccttcg gcgagggcgc cgtcgccctg tgcctggagc gggagagcca     6300

tgcccgggca cgcggcgcgg gcggctacgc ccgcttcctg tcccacaggg cgctgaacga     6360

ggcaacccac cccttcggca tggacatgag cgggcagatc accgcgtccg ccgtcgccgg     6420

ggcgctccag gacgcgggcc gcaccccgcg ggacgtcgac tggttctgcg cgcacggcac     6480

cgccacgccg aagaacgacg tggccgagag ccgcatgctc ggtgccctgt acgagggccg     6540

cccgcggtcc gcctggccgc ccctcagctc cgtcaagccg gtgtacggcc acctcctggg     6600

cgccgccgcc ctggtcaacg cggcggccac ctcgctggcc ctgcaccacc agtgcctgtg     6660

ctcgaccgcc aactacgcgg acgccgtgcc cgacccggag tgcgaccacg accacgtcgc     6720

cgagggggcc cgcgcgaccc gcaccgaact cgcggtgtcg ctggccttcg ccatcggcag     6780

ccagacctcg gtactggcac tcggcgccgc atgaccggtg ccgaacccgc gcggaccgaa     6840

cccctgaagg agaccatgag cacgcacagc ggcaccgcgc cacgccccga catcgtccct     6900

gacgtcgtcc ccgacgtcga ctccctggtg tcccggtacg tgacgccggg gatgcatctg     6960

cacctggcca tgacgatggc gcggcccaac gccatggtct acgcgctggc acggcggttc     7020

gcgggccgcg gcgagttcac cgtcagcacg tcggccacgc acacggccat gcacgcgctg     7080

accatgtcgg gcgcggtcag gcatctgatc acctgcttcc tcggtgacac ctaccccacg     7140

ccgcgcccca acccgctcta ccgcgacctg gcccgcggca tccccttcac ctgcgagttg     7200

tggtccctgc tcagcttcac ccagcgcctg atggccgggg ccacggggct gccgtacgcc     7260

gtgacgtcct cgctcatcgg cagcgatctg gagcgcggtc tcaccggcga cggccccggg     7320

acacgcccgc tgccggaggg cgaacagccg ctcggcggac cgaagttcct gcgcctgccc     7380

ggccggtcgg ccgaagagcg cccgttcggt ctcgtggagc ggctgcgtcc ggacctcacc     7440

ctggtgcacg gcgcctgcgc ggaccggcgc ggcaacatcg tcctcgtgcc gcccgcgggc     7500

gagggcgcct gggccgcgta cgccgccgaa cagggcgtgc tcgcctcggt ggagcgcatc     7560

gtgcccgacg acttcaccga cgggcacccc gaacggatcg tcattcccgg ccggcgcgtg     7620

ctcgccctgt gcgaggcgcc gctgggcgcg cacccgcagt cgctgcgcgg tctcgccacc     7680

ggcgacgagc gcggcgacgt gagcgggtac cgcgacgact acgccttcct caccgagctg     7740

gtggaccggc tggccaccga ggacggcgcc aaggagtggt accgcgagtg ggtggaggag     7800

cccgccgggc acgcgcagta cgtacgcaag ctgggcgagg cgcgccgcgc cgaactgacc     7860

ctcgcctcgg ggccgctcac ctctcgcgag cccgccactc ccccggtgcc gctccccgcg     7920

ggagccatcg ccgccgagcc cgtgacgcgc caggagcgga ccatcgtcct gggcgcccgc     7980

gccatcgccg accgggtcac gcgcgacggc tacgacaccc tgctcgcggg catcggcgtc     8040

tcccacctgg ccgcctggct cgccgccgcg ctcctgcgcg aacagggcgt gcgggtgccg     8100

gtctgcgccg agctgggctt ctacggcatg gaccccgagc ccggcgacgt cttcctcttc     8160

agccagctgc acgccacgcg ttcccagcag ctcgtgggca tccccgagat cctcggcggc     8220

atggtgtcgg cgaacccgcg ctgcctgggc gtcctggccg ccggtgaggt cgacgcggac     8280

ggcaacgtca acaccagcct gctggccgac ggacgctggc tgaccggctc cggcggcgcc     8340

aacgacatcg cgacgagcac cgactgcctg gtgctgtcca cggcttcccc gcgcaagttc     8400

gtcgagcggg tcgcctatgt caccagtccc ggtgcccgcg tacgggaagt ggtcagccac     8460

ttcgggcggt tccggcgcga gcaggacaca cggggggcct tccgcctcgc cacctggctg     8520

ccgctcaacg acggcccggc ctcccccgag gaggccgtgg cggcgctgac ccgctggccg     8580

gtgagcggcg cgggctgcac ggcggaaccg caggtcaccg aggcggagat cgcctggctg     8640

cgcagtctcg atccgcaagg tttctacagg tgacgcgatc cgcaggatcc caccaggtga     8700

ggagcacggt gtgagcggtg gaatctgggt gggccgcggc ctgtccttcc ggggcttcgg     8760

ccactacttc ccgcggcaca gcgaggagat cccggccgac ctgcccgacg cgccggagat     8820

ggaggcggcg gtcctcggcc cggacctcgg cgtggagcgg cggcacctgt ccgacgacac     8880

ggagagcgtg ccgtacatgg ccgtggaggc cggacggcac gcgttgcgca acgccggcct     8940

ggaggcctgc gacctcgacc tggtggtctt ctcctcctgg tcgcagcggc ggtacgcgcc     9000

tgaggacggg ccccggatcg cgatgcgcct cggcgccggg cgggccttgg ccttcgacgt     9060

gtgcgccgcc tgcgtcggct tcgtccactc cgtgcagacg gccgccgcga tgctgaccag     9120

tcaccgctgg cggcacgccc tggtgatctg ctccgaccag ttctcgcgtc ggctcaagcc     9180

cggtcggcgg ggttcgtacg tcggcggcga cggggcgggc gcggccgttc tggaggtggg     9240

ggcgccggac gagtcccggc tgcgggactc cgtcgtgctc agctacggcg agcacgcggg     9300

cgtctccaag gcccgcggca gcgacggctg gacggtgagc ctgcccacga tctcccaggt     9360

ggccgccgcg accgcgggcg aggccacgga cctggtgctg cggcgcaacg acatgaccat     9420

cgccgatgtg gaccgggtcg tgccgcatcc gggctcggca cggatcagtg aggagctggt     9480

gcggcgcatc ggcgtcgccc ccgagcgggt cctgacgaac ctgcggacac gcggccagac     9540

gaccagcgcc acgatcccga gcgccctgtc cgagttcacc gagtccggcg aactgcgcaa     9600

gggcaacgtg atcctgtcgc ccgcggccgg cgcggggtgg ttctcgggcg ccctgctcta     9660

ccagctctga cgcaccgacg gacagcacac aacgacggga agacgaggaa aggacctccc     9720

ccatgcccga aacccggtca ccgctcgacg gcggaggccc gccggtcgtg ctcagtggtg     9780

tcggccacta cttccccggc gagccggtca ccaacgacca cttcgcccgc ctgcccgagc     9840

tggacgtgga cgacgcctgg atacgcgcgt acacgggcgt gcggacccgt cactgggccg     9900

gccccgagga acggttcgcc gagatgggcg tcaaggcggc ccggcgcgct ctcgacgacg     9960

cgggcctcga catctccgac gtggacgtga tcgtcggcac cagcgcgacc gcccggccac    10020

gtgccaaccc ctcctccctc ggcaacaact acatggacat ctccctgccg gtgcagcggc    10080

agctgggcgc ccgtgacgcg ttctgcttcg acgtgaccgc ggtcgcctgc gcaggattcc    10140

tgtacgcgag cgtggtggcc cgcgggctgc tggcgacgac gggggcccgg accgccctcg    10200

tcgtgtgcgc ggaaagcccg cacgccatcc tcaacttcgg gttcaagaac tccgcgctct    10260

tcggcgcggg cgcggcggcc gcggtgtggc ggcgcggcga gtcctcgggc ggcggcgccg    10320

acggcctgcc gacgcgcagc ggcatgatcg acgtcgtcct gcgcgccgac ggccgctact    10380

acgacgcctt cgacatcgac gagaacgaca agatggtgat gcgcggcggg gtgctctccg    10440

aggtcacgcc cgacatgctc gtcgacgccg gagagacggt cctcaagcgc aacggcctgg    10500

caccggaaca gatttcctgg tgcattccgc atcaggcgaa caccaacctc ctgtatccga    10560

tggcggaccg cctcggaatt ccgcgcgagc ggatgctcct gaatcttccg cgccgcggca    10620

acacatcgag tgtgggaatg ccgagcgcgc tctccgaata cgtcggtgac ggcacggtga    10680

aacccggcga actactcctg ggcgtaagca tcgggcgcgg cctgagctgg ggcgccatgg    10740

ttttccggta ccagtgaacg gccgtaccgc cgcggcgcac gcgacaaccg agagcgagag    10800

gtgaacggcc atgtccgatt ccaggaatgc gctggtgacc gggggaaccc gcggcctcgg    10860

cctggccgtc gcccggctgc tggtggcgcg gggatggcgc accacggtcc tcggcctcga    10920

cccgggacgc ctggagaagg tgcgggccat ggccgaggcc gagggcctgg acctgcgcgc    10980

ggtgcgggcc gatgtcacct cggaggagtc ggtgcgggag gtgttcgccg acctgacccg    11040

gagcgagccg ctgcacctgt gcgtgaacaa cgcgggccgc aacctctccc gtctgctact    11100

gcgcgaaccg cgggagggca gcggcgccga gctgctcacg catccgctcg acgactggga    11160

gcagacgctg cggctgtgcc tgacgggggt cttcctcgtc ggccgcgagg ccgccgccgg    11220

catggtgcgg cacggggtgc ccggcgccat cgtcaacgtc tcctccggtc tcgcggcggg    11280

cgcctacggg cagtccgcgt acaccgccgc gaaggcgggc gtggaggcgc tgacccgtac    11340

ctggtcctat gaactcggcc cctacgggat cagggtggcg gcggtcgcgc cgggcgtgat    11400

ggacggtgag gcactgcgcg agaagagcac ggcctttcca cggcacgccc gttatatgga    11460

cgggctgaag cgttttgtcc cgctgggccg ttgggggacg gaggaagaga tagcggacgc    11520

ggtgtgcttc gccgcggaaa acccctatat caccggatcg gtcattcggg tcgacggcgg    11580

cgggccgccc ggctgggttc cgtaacgacg ccacccgtgg gtgaactacg gctttttcgc    11640

ggggtacttc gagtacccgc ggcatgaatc atcgagtact ggaggccaga tgcagccgaa    11700

tgccgacgcc actagttttt cgtccatgac cacaggcctg cacggaatct gggaagacgc    11760

cggaatacgt ttcaccggat tcggccacta tttcggctcc gaggaaatac acaaccacgg    11820

cgtcgagaac gcgacgacga gccacgtgga ggaccgcgtc atcggcgggg tcggtgtccg    11880

cacccgctac cgggccaacg acgacgagac ccccgtgttc atggccgcgc aggcctcccg    11940

gcaggcgctg gagcaggccg gggtcgacgc cgacgacatc gatgtgatgg tcgtcagcca    12000

ttggacggac cgcaactacg tgcacgaggt gggcgcgctc accgcggcgg agctgggaat    12060

gaagggctcc atggccttcg aggtgtgcgg ctcctgcgcc ggtttcatcc aggcggtgca    12120

caccgcggcg tcgttcctga ccgccccgac cggctaccgc aaggcgctgg tggccaccac    12180

cgagcgggtc acgcggcggg tgcggcccgg ctccaagggc tcaatgctcg tctcggacgg    12240

cgccggcgcg tgtgtcctcg aagccacccc cggcggctcc cccgggctca tcgactccgt    12300

gttccacacc gacggcagcc tcgcccacat gtccgcggcg agcggggaca agggatgggt    12360

gaagagccac ccggacctca acgacgtcgc cctggcccac atcagcgaca ccgtggagga    12420

gatcctcggc cgcaacaaac tggcgatcgg cgacatcgac tggctcatcc cccactcggg    12480

gaccgagccg ctggccaagg gcatccagca caacctggga gcggacccgg cgcgcgtcct    12540

gaccaacctc gccttccgcg gcaacgtctc cagcgcctcc atccccacca ccgtctcgga    12600

actgcgggag cgcggcgtcg tcaaacccgg cgacctggtg ctctccccct ccatcggcgg    12660

cggcgtctgg tgctggggca gcctcctgta ccggatctga gcgaagggcc aatgcggtga    12720

ccacgaccaa gggcccccgg gacgcactcg tcaccggcat gggcttctgt ctgccggggc    12780

gtacggcgcc gacggcgaca cccgagcagt tctggacggc cgtcgcgcac ggcgactcct    12840

tcctcgcgca ggacgacggc acctacttcg gcagcgtccc cctagacccg gactccgtcg    12900

ccgctcgact gccggagatc ccgccgcgct tcgtcgagaa gtactccgac atccatctgt    12960

acgggctgct cgccctcctg gaggcgtgcg aggacgccgc gctcgactgg cgttcgggcg    13020

cactgggcga ggccgccgta ctcgcgggcc gcaacgccac ggccgacgcc atcgtcgaca    13080

cgtatctgcc ggtgctcctc gccgacaccc ggaacatcag cccgcgcgag gcccgctcga    13140

tactgttccg caacgttctc aacgcggtga tgtcggacgt cgagacgacc caggcgggcc    13200

tcgtcggcgc caccggcccc agctacacgc tgtcctgcgg gtgcgcctcc tcgtccgtgc    13260

tgctcggcaa cgcggcccgc atgatcgcag cgggcgagac ggacatcgcg gtggtcaccg    13320

gcgccgacta ctggcgcgag agcagactgc ggcagtacgc ggacctcgag gcacgctcgg    13380

tgaccgggag cgaaccgcag accgccaccc tcgtcgacga gcccatgcgc ccctacgacc    13440

agcgggccgc cggcctcaac tacggcaacg gcgcggccac cttgatcctg gagagccgcg    13500

agcacgcgcg gcgcaggggc gccaggacct acggacggct cctgggccag accaccaccc    13560

gcaacgccca gcccaacctc gccctcgacg tcgagggcac gggggcggtg cgcgccgcgc    13620

gctcctgcat ggccgggatc gcatcgccgg acgagatcga ctacgtcaac ggcgccgcga    13680

ccggcgaccg ggcgttcaac ctcatggaag gcaacatcat gcccgccatc ttcggtgagc    13740

gggcggcccg gctgcccgtc accgtccagg aggccgtgtt cggacacagc ggggccccgc    13800

tcggagtgat cggtgtggcg gcgacgctcc agatgatggg ccacggccac atcgccccga    13860

ccgcgaactg cgagaagccc gccgacgtgt gcaccttcga cccggtgccc ggcacccagg    13920

ggcggcccgc gcgcatcgac ctggccctca gtctcaacta cacgatcggc tccgtggcca    13980

gcgccattct cctgggaggc accgatgact gagcacacgc cgcccggcgc cgggcccgtg    14040

ctcgaaacgg gctccctggc gcccgtcggc cgccgcgtcc tgctggagtc cccgcccggc    14100

gccgaccaca cgcgggcggt ccgggaggtc tgggagcgac acggcttcca cgtcacgcac    14160

gacgagagcg cgcacatgac ccagcccccg gacgtgtact gcgtcgtggc catcggcaac    14220

gaagcactcg gcgcccggcc ctcacctccg ttgcgccgcc cccacgtggc ccgggtcctg    14280

aaggccatgg cccgacgggg cgagggccgc gccgtcctgg tcaccgacac gggcccgcac    14340

gtccacgacg acgcggagcc cgaggccgcc gcacagcggg ccgccgacca cgcgtggtgg    14400

cagcacctgg ccaagcactg cgcgagccgg ggcgtgctcg ccaacacggt gcgcgtcggc    14460

tacaccccgt tcctcgggca cgagctgacc gacgaggcgg cgggtgaact gctgcgccac    14520

ctggtcaccc gccgccccgt cgcaccggag gaactggcgg cggcactgcg gctgctggcc    14580

tcgcgcggct tcggcaacgt cgcgggcgag acgctgccgc tggacggcgg actcgacgcg    14640

agcatcgtgc ccatgccttc ggcacgccca ccgcgaatgg acgcgtccgc cgccgaaggt    14700

gacggcgccg cggtgcccga cccgttccgg ctgaccggac gtgtggtcct ggtcaccggc    14760

gccagcagcg ggatcggggc gagtatcgct cgggagtgcg cggcacgcgg cgccgatgtc    14820

gtcctggccg cgcgccgccg cccggagctg gagaagctcg ccgccgaggt ccgcgaactg    14880

ggccgcacgg cctgggtgtt gaccgccgac ctgtcggatc cggcgcgggc cgccgacctc    14940

gtgcacgagg cgtgggagcg tgccggaggc gtcgacgcgc tcgcctacgg cgcgggcgcc    15000

gtctccttcg acggctccgg tgacaactcc gccaaccgac agcagttgct ggccctcaac    15060

tcgctgtcgt acgcgggtat gtgtgacgcg ctgctcgaac actgggtggc tgcgggccga    15120

agcggggccg tggccgccgt ctcctcgctg gccgcggtga gcgcgccggt ggcgaacctg    15180

gcgagctacg ggctcagcaa ggcggcgacc gcgcagttca ccacccactt cgcgacctcg    15240

gcggcccggc acaaggtgcg ggccaacagc gtgcttccgg gtttcgtccg caccccgatg    15300

acggacgtca ccaaccccgc gttcctggag gccaccaacc ggctcgtgcc gaccggccgg    15360

atgagcgagg cgacagaggt cgcggcgctc gtctgctacc tgatcagccc cgccgctgcc    15420

gggctgaccg gcacccagct gcgcgtcgac ggcggcggtc actgcctggc cggactgccg    15480

aacctggccc cacccgagca cacccttcga ggaaggaacc cggctgtgac gccctgcgta    15540

ccacgccccc gccccgccgt gccggaaggg gaccacaggt gaccgaggac aggcccctca    15600

agggcaaggt ggcgctggtc gccggcgcct cgtccggcat cggggcgagc atcgcccgcg    15660

cgctggcggc ggccggcgcc tctgtcgccc tcgtcgcccg ccgcaaggac caactggcct    15720

gcgtcgagcg cgacgtggcc gggcacgagg tgcccgccgt cacgctcatc gccgacctgt    15780

cggccgacgg cgtgcccaag gagacggtga ccgccgccga gcgggccctc ggccccgtcg    15840

acatcctggt gaacaacgcc gccctggctc gcaccggacc catccacgac accaaccccc    15900

gccactggcg gcaggccttc cacctcaatc tggacgtccc cttcctgctg gcccgcacgg    15960

tgctccccgg gatgcgcgag cgcggccacg gctggatcgt caacatcagc tcggagggca    16020

gtctcctaca ggccgactgg tcggccccgt actccatcac caaacgcgcc ctgaacgcgc    16080

tgaccgcgca aatcgacctg gagaaccggc acttgggggt ccgcgccatc gccgtgctgc    16140

ccggctgggt gcgcacggac ctggcgcagg accccgagtc gctgggggtg ggtgtcacgg    16200

atctgctgga cccctcggac atcgccgatg tcgtgctgtg ggccatcacc cgcccgcccg    16260

ctgtcagcat cggcccgctg ataccggtac gccccgtcag caggagtgcc cagaccttgg    16320

tcaactggga gcagtacctg cggacgctgc gccattacga cgcctccggc ggtcacatgg    16380

tcgacgtgcc cgggatccct gaatgacggg ccccacgacg tcagcggcca cggcggcgcg    16440

ggatctcgac gtggcggccg accgcctcgt cgagatcctc ccgccggggg acgcacgggt    16500

accggacgcc gagcactgcg tcacgggcgc gctgctcgcc gcccgcgccg aggcccatcc    16560

cgaccgcgtg tacgccgtct tcgaggacgg cacccactgg acgtacgggc aggcctacga    16620

cgacgcgcgc accaccgccg ccgccctgta ccggctgggc gtgcgtcagg gcgacaccgt    16680

gctgtgctgg ctgcccaacg gcctggacgc gctgcgcgtc tggtacggcg tcaatctcct    16740

cggcgccgtc cacgtccctg tcaacaccgc ctatcggggc gcgctcctgg aacacgtact    16800

ggacaactcc ggggcccggg tccttgtggt gcacgcgctg ctcgtcgagc ggctccagca    16860

catcggcgac agccgcctcc aggaggtcgt cgtcctcggc ggcggaccgg acgcgccctg    16920

gccggacgcc ctgcccggtg ccccgcgcgt gcacggtccc gcggcgctgc ggggcctgcc    16980

ggaggacttc gtcccgcccg agcggccggt cgcgccctgg gacaccatgg cggtgatcta    17040

cacctcgggc accaccggcc cgtccaaggg cgtcctggtc tcctacgtcc atcactactc    17100

gacggtgacc gcgctcctcg acgacgacat cggcgaggac gaccggtatc tgctcaacct    17160

gccgctgtgc cacggcggcg gtaccgaagt cgcctactgc atgctcctgt tcgggggctc    17220

gatcgtcgtc accgagaact tccgcaccgg cgagttctgg gacgtggtgc gccgccacgg    17280

ggtgaccatg tgcaccctgc tcggcgccat ggtcgacttc ctgctcggtc tggccccccg    17340

gccggacgag gccgaacacc cgctgcgggc cgcgtgcgtg ataccgctga cgcgccaggc    17400

cctggacttc ggccgccgct tcggcgtgga cgtctacacc gggttcaaca tgtccgagac    17460

ctcggcgccg ctggtgtcac cgctcaatcc gcagcgcacg ggcagctgcg ggcggccgcg    17520

gccgggggtg cagtgccggg tggtcgacgc gaacggcatc gacgtacccg acggcagcgt    17580

gggcgagctg gtgctgcgcg ccgaccggcc gtggtcgctg ttccacggct accacgccat    17640

gccggaggcc accgcggggg catggcggca cggctggttc cgcaccgggg acgccgtggt    17700

gcgtgagccc ggcggcgact acttcttcgt ggaccgcatc aaggacgcca tccggcgccg    17760

cggcgagaac gtgtcctcga tggaggtcga agccgagttg ctgagccatc ccgccgtggc    17820

gttcgccgcc gccgtggcgg tgcccagcga cttcgccgag gacgagatac tcgccgccct    17880

cgtgctccgg cccggggccc gtttcgaacc ggaggagttc atcgggtacc tgcggcctcg    17940

catggcgcac ttcatggtgc cgcgctatct gcgtgtcctg tccgagcttc ccgtgacgga    18000

cacgggcaag gtccgcaagg agacgctgcg cgcccagggc gtcacccccg acacctggga    18060

ccgcgtggcg gccgggatcg aggtcacccg tgaccgcatc cgctgagccg gccgcccccg    18120

cgcaccgtgt cgtcgacgtc tgcgcgctgt ccctggaccg cgagtgctgg cggacgtact    18180

tccgcgggct cggcgcggtg gcgccggcgt acctgcgcgc cttcggccgg cacgcgaccg    18240

cggtcttcgg cgccgattac ccgcgcttcc gtgcccgcct agacgccggg gaccaggacg    18300

gtgccgtcga cctgctcgtg tcgggtcagc ccgaacgcgt cgactccgac gcgctgttga    18360

agaccatgga cgacaacggc gtcgtccacc agatcctgat gagctgcggc ggcgccaccg    18420

ccgacggcga cgacgtcaac agccgggtcg ccgccgtcgc cgccaaggcg cccgaccggc    18480

tccgggcctg ggcgggcatt gacctgaccg acccgggccg tgccgtcgcc gagctggaac    18540

gctgccatct tctcggtatg cgcggcttcg cggtgacccc gttctggcag ggcgtcgacc    18600

cgcgcgacac cgcgtacgac ccggtctacc gcagggcacg agagctgggc atgccgttgt    18660

ggctgcacac cgggcaccac ttctcgcggc acgcggccga gttgtgccat ccccgcaacg    18720

tcgactggat cgccctgcgt caccccggcc tgccgatcgt cgcggggcac gccgcctggc    18780

cctggaccct tgagctgatc tccatcgccc agcggcaccg ccacgtctac ctcgacatct    18840

cctcccaccg accgcagtgg atggcccgcc ccggatcggg ctgggaatcc ctgctcctgt    18900

acggcaccac ggtgctgcgc gaccgggtcc tgttcggctc ggcgacctgg gtcaacgccg    18960

atccggtcgc cgcgctcgcc cggcaggtcg ccgccctgga tctcggcgac gaggtcacgg    19020

acctctggct gtacggcaac gcggcccgcc tgctcggact cggccccggc tgacgccggt    19080

gcgcgcgccc cagcacagaa ccagcacgta tccagcagag agcacgtaat cagcagagag    19140

cacctatcca gcagagaaag ggacccatcg tgattgaccc cgccgactac gccctgtgga    19200

acagcggcgt gccgcgcccg tacctcaagg cgctgtcccg cgacgacctg ctcaccgagg    19260

gcgacggcgt gcgcgtccgt gactccggtg gccgctggta cctggacggc cgctccgggc    19320

tgtggaacgt gacgctcggc tacggcaaca cccgcgtcaa ggaggccatc aagcagcagg    19380

tggaccggct gccgttcgcc aacagctacg gctacggacg tcccgcgcag gtcaccgtgg    19440

actgcgccga ggccctcgtc cgtcatctgc ccgagggcat caaccacgtc cggttcgcca    19500

gcaacggggc ccaggcggtg gagatggccc tccagctgtc gcgcttcctg cggctgcggg    19560

ccgggcagcc cgagcgcatg gccgtgttcg ccatgtggga cggcttccac gggcaggggc    19620

cgggcgccgg catggtgacc ggtgtcccct acctgcacca ccagaccggg ccgatgctcc    19680

ccgaggtgca ccacgctccc ggcccgttct cggcgggcgc gacgcagggc gtcagcgaca    19740

tggaacggct gatcaccgag ttcggccccg agcgggtgac cgcggtgatc gtggagcccg    19800

tcgtcggcga gggcggccac atcctgtccc ccgagtacct cggctccctg ggccggttct    19860

gccgtcagca cgacatccat ctgatcttcg acgaggtcgt caccggcatg ggccgggtcg    19920

gcgacttcac ccgcgccggc caactgcccg atgtcacccc cgacatcatc accctgggca    19980

agggcatcac ctcggggtac gtgccgatgt cggccgtcgc catccacgac cgcctctacg    20040

agcagctgca cgagcgcacc acgggcgaca ccgcgctcag cgtcggctcg accaacgacg    20100

gccacgcggt ggccgctgcg gcggcgctcg cggtgatcgg ggcgctcacc gaggacggcg    20160

tgctggagaa cgtacgccgc cgtgaggctg atctcctctc cgccctgggc aagctccagg    20220

cccagcaccc cgagctgagg gccttccgcg ctctcggcct gttctgcggc ctggagctcg    20280

gcgagcccgg cggtccgtcg tggtccccgg gcaaggtgaa ccagctgcgc atgaccttgg    20340

agagccgagg cgtgctcagc tccagcctgc gtgtcgtacc gaatctgatg ctcatgccgc    20400

cgctggtcat caccgaggac gacgtggcgg agatagccga tgcgctcgac ggcgcgctca    20460

ccgatgtgaa gtcgggtcgg cgccccgagt ccgggttcgc caaggccatg ggatgactcg    20520

tcagggccac gggacggcaa cgcgttttct ccacgtgatg gaaggtgagt gacgacatgt    20580

ccaatgcgca caccgatcgc aagaccagca agcagtggca ggaagaggcg gcggaggagt    20640

gggaccggta cgccgacatc tgggacagct ggacccccga tgacagccgg gacgatgccg    20700

aggaggccgc ggacttcctc gcgggcctcg ccaagggcgg caccgccctg gagctgggga    20760

tcgggacggg ccgcgtagcc ctgccgctcg cgcagcgcgg cgtgcgggtg gccggtatcg    20820

acgcctcgcc gaagatgctg ctgaagctca aggagaagcc gggcggggac cggatcgagg    20880

tcttcgaggg caacttcgcc gatgtcgacg tcaaggagga ctacgacgtc atcttcatcg    20940

ccctcgccac cctgttcgtc ctgcccgacc aggacgagca ggcccgctgc ctggccaaca    21000

gtgccaagcg gctcaagccg ggcgggcggc tcgtcgtcca gaacatcgtg ccggacatga    21060

cgtactacca gcgcgggcgg cagaacgact acgggatgac cgagccgttc cgtatctcgg    21120

gccggctggc cgggcacccg cggctcgcct ggttcgagat gaaccacgtc gacccgacga    21180

cgcagatggt caagcgcacg gacgtcatca tgagcgagaa gggcaaccgc atcatcgcgg    21240

cgaccatgcg gttcgtgtgg ccctcggagc aggacctgat ggcccggctg ggcggcctga    21300

cgctggagga ccgctgggga ggctggcgca aggagccctt ccactacgac agcagggacg    21360

cggtgtccgt ctaccgcaag cagtgaccgt ccggcgccgg acgtgaccga ggccgggggc    21420

ggcgaccagc cgctcccggc ctcggccgca ccgagcgtgc ccgaacctgc ccgtacaggc    21480

atcgggggta ctcgaacggg ccgcaggacg agtacttcca gggcgtaggt agccggtgga    21540

accgtcacta cgctgatggt tccgaccccc gtcaagtgca ccgattcagg gtgggcagaa    21600

gcaatgagcg aagagttcgg gcaggatcgt ccggccgaag cgggcagcgg gagcggcacg    21660

gacgtgctcg tcgagcgccg cggccccgtg ctcgtgatcc aactgaaccg gccgcgcgta    21720

cgcaacgcgc tgacccgcgc catggccgaa cggctcgccg ccgccttcac ggaactggat    21780

gcccgagcgg agctgcgtct cggcgtcctg accggcaccc cgccggcgtt ctgctccggc    21840

atggacctcg gggccttcgc ccgcggggag cgcgcctccc tgccggggcg tggcttcggc    21900

ggtctgacgg agcagccgcc gagcaagccg ctgatcgccg ccgtggaggg tgcggcggtc    21960

ggcggtggtt tcgagatggt gctcgcctgc gacatggtgg tggcggcgga cgacgcggtg    22020

ttcgggctgc ccgagctgcg ccgagggctg gtggccgcgg ccggcggact gctgcggctg    22080

ccgcgcgcga tcgcgccggc cgtggcgatg gagatggcac tgaccggcga accgatcgat    22140

gcgcagcggg ccttcgcgct gggtcttgtc aaccgtgtgg tggccccggg gacggcgctg    22200

acggccgcct gcgagctggc ggagaagatc gccgcgcatg cggaccacgc cgtcctcgcg    22260

agcaaggggg tcctcgctcg ggtgcgcgac ggggagttgg cggacgagta ccggtcgcac    22320

cgcgagctgc tgtcggggat cctcgactcc cccggcgcgc gggcaggtgc gcgtgagttc    22380

gtccgggaac gtccgggcgg accgcgatga cgtgcacgga cggggaccgg atggtcaacc    22440

ccgggccccg gtggtcaccc cggtcggaga ggagtactta cggaacagtt cacgtcggcc    22500

gctgacgccc agtttccgca gggcgctact gacttgattc tttatggtct gggaggccag    22560

ggagagttcg ctggcgattt cctcgttggt atagcggcgc agtacgaggc tcaggacctg    22620

ctcttcccgg cgggtgatgg cgggcagccc gtcgggcatg acgctgcgca cgtccacgtg    22680

ttcgcgttcg ttcttgccaa gtatccacat gcgttggccg ttgtacgtgc gcaccaccgc    22740

gtccacgagt tccgaactgc ccacgctctt gtgcaggaag ctgtcggccc ccgccgatat    22800

ggcggagacg acggccccgg gcgaggtgtc tccggtgaag acgacgaccc ggggcgcgtc    22860

ctccatcgcc ttcacccgtt ggcagagatc ggcaccgctg gtcgcgccgt ccagttccag    22920

ttcgagtacg acgacacccg ggcaggacgt tgtgacggca ttccacgcct cgtcactcgt    22980

ggcggcctcc gccgtccacg ccactctcgt gtcgagcagt gacgacagcg cgtacctgac    23040

cacggggtgg cgatcgacga cgagtacacc taacgcttgc atggggactc ctcacgcagt    23100

gagtgcagcg gatgggtagt caggtctgca atgctccgag atgtgcctgc gccacgctcc    23160

ggatgccgcc ccgagggcgg cgcgtcgaga cgagcggtat cagacgagct gggtcagtcg    23220

ctgcgtgggc ccgtggcctc ccgcacggct gactccaggg ggcgggctgg tcaggccggc    23280

actcggagtc attcaatgtc acgtaatcaa tcgtgggaca acaccccgtt ggacattcc     23339


<210>  3
<211>  231
<212>  DNA
<213>  Streptomyces alboniger

<400>  3
gtgtacgaat cggtcaagtc cctgctcacc aacgaattca agatctccga ggaccggata       60

gccccggact ccacgctgga ggacctcggc ctggactccc tggcgtcggt cgagttcgcc      120

ctcgccctgg agaagggatt cggcgtggag atcaccgacg acgaggtcgt cgagctggag      180

cggctcgaca ggatcgtcga actcgtcgag cgccgcaagc aagcatcctg a               231


<210>  4
<211>  76
<212>  PRT
<213>  Streptomyces alboniger

<400>  4

Val Tyr Glu Ser Val Lys Ser Leu Leu Thr Asn Glu Phe Lys Ile Ser 
1               5                   10                  15      


Glu Asp Arg Ile Ala Pro Asp Ser Thr Leu Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Glu Val Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Val Glu Leu Val Glu Arg Arg Lys Gln Ala Ser 
65                  70                  75      


<210>  5
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamC polypeptide

<400>  5

Val Tyr Glu Ser Val Lys Ser Leu Leu Thr Asn Glu Phe Lys Ile Ser 
1               5                   10                  15      


Glu Glu Arg Ile Ala Pro Asp Ser Thr Leu Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Met Ala Leu Glu Lys Gly Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Glu Glu Val Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Val Glu Leu Val Glu Arg Arg Arg Gln Ala Ser 
65                  70                  75      


<210>  6
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamC polypeptide

<400>  6

Ile Tyr Glu Ser Val Lys Ser Leu Leu Thr Asn Glu Phe Lys Ile Ser 
1               5                   10                  15      


Glu Asp Lys Ile Ala Pro Asp Ser Thr Leu Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Glu Glu Val Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Leu Glu Leu Val Glu Arg Arg Lys Gln Ala Ser 
65                  70                  75      


<210>  7
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamC polypeptide

<400>  7

Val Phe Glu Ser Val Lys Ser Leu Leu Ser Asn Glu Phe Lys Val Ser 
1               5                   10                  15      


Glu Asp Arg Ile Ala Pro Asp Ser Thr Leu Asp Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Glu Asp Val Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Val Glu Leu Val Glu Arg Arg Lys Gln Ala Ser 
65                  70                  75      


<210>  8
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamC polypeptide

<400>  8

Leu Tyr Glu Ser Val Lys Ser Leu Leu Thr Asn Glu Phe Lys Val Ser 
1               5                   10                  15      


Glu Asp Arg Ile Ala Pro Asp Ser Thr Leu Asp Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Met Ala Leu Glu Lys Ala Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Glu Asp Leu Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Val Glu Leu Val Glu Arg Arg Lys Gln Ala Ser 
65                  70                  75      


<210>  9
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamC polypeptide

<400>  9

Ile Phe Asp Ser Val Lys Ser Leu Leu Thr Asn Glu Phe Lys Ile Ser 
1               5                   10                  15      


Glu Glu Arg Ile Ala Pro Glu Thr Ser Leu Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Phe Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Glu Val Val Glu Leu Glu Arg Leu Asp Arg 
    50                  55                  60                  


Ile Val Asp Leu Val Glu Arg Arg Lys Gln Ala Ser 
65                  70                  75      


<210>  10
<211>  1035
<212>  DNA
<213>  Streptomyces alboniger

<400>  10
atggaccaca acaggacacg cgcggccgtg ctggcgggcg tcgccggctg ggtgccgccc       60

ggcacggtca ccaacgccga cctggaagcc cgcctcgaca ccaccgacga ctggatccgc      120

agccgcaccg gcatcgccga gcggcacacc gtcccgccgg gcatggccac gcgggaactg      180

gccgtggagg cggggcggct ggccctgaag tcggccggcc gcgacgacgt ggacgcggtc      240

gtcctcgcga cggcgacccc ggaccgcctc tgcccggcca ccgcccccga ggtcgcggcg      300

gcgctcgggc tcggccccgt cgccgcgcac gacgtcgccg ccgtctgcgc cggattcctg      360

tacgcgctgt cggcaggagt cggggcgatc gccgcgggct tcgccgaccg cgtcctggtc      420

atcggcgccg agaccttctc cgccatcgtc gacccgcagg accgcaacac ggccgtcatc      480

ttcggcgacg ccgccggagc cgtcgtgctg cgcgccggtg accccgacga gccgggagcc      540

atcggcccga tccggctcgg cagcgacggc acgcacagcg acctcatcca gatccccgcg      600

ggcggtgccc ggcagcgcgc cgcccggacc gtgcccgagc cgagcgatca ccacctacag      660

atgcagggcc gcaaggtcta ccggcacgcg aaggagcgca tggcacagtc ggcgcgcgag      720

gtcatcgagc gctccggctg gacggtcgag gacgtcgacc gtctggcgac ccatcaggcc      780

aacgcacgca tcagcgaagc cgtcgccgac gaactgggcg tcccgcgcga ccgcgtcctg      840

tccaacatcg agcatgtcgg caacacctcg gccgcgtccc ttcccctgct gctcgccgac      900

tcggccgcgg cgggcaggct gcggacgaac gaccgggtgc tgctcgcggc gttcggcggc      960

gggctcgcct ggggcgcggc ctctctgacg tggccggacg tcacggccct ggccgtgcat     1020

acgtaccgcg gctga                                                      1035


<210>  11
<211>  344
<212>  PRT
<213>  Streptomyces alboniger

<400>  11

Met Asp His Asn Arg Thr Arg Ala Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Asp Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Thr Thr Asp Asp Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Thr Val Pro Pro Gly Met Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Leu Ala Leu Lys Ser Ala Gly Arg Asp Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Asp Arg Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Ile Val Asp Pro Gln Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Asp Leu Ile Gln Ile Pro Ala Gly Gly Ala Arg Gln Arg Ala Ala 
        195                 200                 205             


Arg Thr Val Pro Glu Pro Ser Asp His His Leu Gln Met Gln Gly Arg 
    210                 215                 220                 


Lys Val Tyr Arg His Ala Lys Glu Arg Met Ala Gln Ser Ala Arg Glu 
225                 230                 235                 240 


Val Ile Glu Arg Ser Gly Trp Thr Val Glu Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Glu Ala Val Ala Asp Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Val Leu Ser Asn Ile Glu His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Arg Leu Arg Thr Asn Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ser Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  12
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamG polypeptide

<400>  12

Met Asp His Asn Arg Thr Arg Ala Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Asp Leu Asp Ala Arg Ile 
            20                  25                  30          


Asp Thr Thr Asp Asp Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Thr Val Pro Pro Gly Met Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Leu Ala Leu Lys Ser Ala Gly Arg Asp Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Asp Lys Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Ile Val Asp Pro Gln Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Ile Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Glu Val Ile Gln Ile Pro Ala Gly Gly Ala Arg Gln Arg Ala Ala 
        195                 200                 205             


Arg Thr Val Pro Asp Pro Ser Asp His His Leu Gln Met Gln Gly Arg 
    210                 215                 220                 


Lys Val Tyr Lys His Ala Lys Glu Arg Val Ala Gln Ser Ala Arg Glu 
225                 230                 235                 240 


Val Ile Glu Arg Ser Gly Trp Thr Val Asp Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Glu Ala Val Ala Asp Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Ile Val Ser Asn Ile Glu His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Lys Leu Lys Thr Asn Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Val Ala Phe Gly Ala Ala Ser Leu Thr Phe Pro Asp Ile Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  13
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamG polypeptide

<400>  13

Met Asp His Asn Arg Thr Arg Ala Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Leu Pro Pro Ala Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Thr Leu Pro Pro Gly Met Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Lys Leu Ala Leu Lys Ser Ala Gly Arg Asp Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Ala 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Asp Arg Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Ile Val Asp Pro Gln Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Val Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Glu Leu Ile Gln Ile Pro Ala Gly Gly Ala Arg Gln Arg Ala Ala 
        195                 200                 205             


Arg Ser Val Pro Glu Pro Ser Asp His His Leu Gln Val Gln Gly Arg 
    210                 215                 220                 


Lys Val Phe Arg His Ala Lys Glu Arg Met Ala Gln Thr Ala Arg Glu 
225                 230                 235                 240 


Val Ile Asp Arg Ser Gly Trp Thr Val Glu Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Ser His Gln Ala Asn Ala Arg Ile Ser Glu Ala Leu Ala Asp Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Val Leu Ser Asn Ile Glu His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Lys Leu Arg Thr Asn Asp Lys Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ser Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  14
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamG polypeptide

<400>  14

Met Asp His Asn Lys Thr Arg Gly Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Asp Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Thr Ser Asp Asp Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Thr Val Pro Pro Gly Met Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Ile Ala Leu Arg Ser Ala Gly Arg Glu Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Gly Thr Pro Asp Arg Leu Cys Pro Ala Ser Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Ala 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Gly Asp Lys Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Leu Val Asp Pro Gln Asp Arg Asn Ser Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Glu Leu Leu Gln Leu Pro Ala Gly Gly Ala Arg Gln Arg Ala Ala 
        195                 200                 205             


Arg Thr Val Pro Glu Pro Ser Asp His His Val Gln Met Gln Gly Lys 
    210                 215                 220                 


Lys Val Tyr Arg His Ala Lys Glu Lys Leu Ala Gln Ser Ala Arg Glu 
225                 230                 235                 240 


Val Ile Glu Arg Ser Gly Trp Ser Val Glu Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Asp Ala Ile Ala Asp Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Ile Leu Thr Asn Ile Glu His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Arg Leu Arg Thr Asn Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ser Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  15
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamG polypeptide

<400>  15

Met Asp His Asn Lys Thr Arg Ala Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Leu Pro Pro Gly Thr Val Thr Asn Ala Asp Leu Asp Ala Arg Met 
            20                  25                  30          


Asp Thr Thr Glu Asp Trp Ile Arg Ser Arg Ser Gly Ile Gly Glu Arg 
        35                  40                  45              


His Thr Val Pro Pro Gly Val Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Leu Ala Leu Lys Ser Ala Gly Arg Glu Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Met Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Asp Arg Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Leu Leu Asp Pro Gln Asp Arg Asn Thr Gly Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Lys Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Glu Leu Val Gln Ile Pro Gly Gly Gly Ala Arg Gln Arg Ala Ala 
        195                 200                 205             


Arg Ser Val Pro Glu Pro Ser Asp His His Ile Gln Met Gln Gly Lys 
    210                 215                 220                 


Lys Val Phe Arg His Ala Lys Glu Arg Ile Ala Asn Ser Ala Arg Asp 
225                 230                 235                 240 


Val Ile Glu Arg Ser Gly Phe Thr Ile Glu Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Asp Ala Leu Ala Glu Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Ile Leu Ser Asn Ile Asp His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Arg Ile Lys Thr Asn Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ser Leu Thr Tyr Pro Glu Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  16
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamG polypeptide

<400>  16

Met Asp His Asn Arg Thr Arg Gly Ala Val Leu Ala Gly Val Ala Gly 
1               5                   10                  15      


Trp Leu Pro Pro Gly Thr Val Thr Asn Ala Asp Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Ser Ser Asp Asp Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Thr Val Pro Pro Gly Met Ala Thr Arg Asp Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Leu Ala Leu Lys Thr Ala Gly Arg Asp Asp Val Asp Ala Val 
65                  70                  75                  80  


Val Val Ala Thr Gly Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ala Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Val Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Asp Arg Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Ala Ile Val Glu Pro Gln Asp Arg Asn Ser Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Ala Asp Pro Glu 
                165                 170                 175     


Glu Pro Gly Gly Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Ser His 
            180                 185                 190         


Thr Asp Val Leu Gln Val Pro Ala Gly Gly Ala Lys Asn Arg Ala Ala 
        195                 200                 205             


Lys Thr Val Pro Glu Pro Ser Asp His His Ile Asn Met Gln Gly Lys 
    210                 215                 220                 


Lys Val Phe Arg His Ala Arg Glu Lys Met Ala Gln Ser Ala Arg Asp 
225                 230                 235                 240 


Val Ile Glu Arg Ser Gly Trp Thr Val Glu Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Asp Ala Leu Ala Asp Glu Leu 
            260                 265                 270         


Gly Val Pro Arg Asp Arg Val Val Ser Asn Ile Glu His Val Gly Asn 
        275                 280                 285             


Thr Ser Ala Ala Ser Leu Pro Leu Met Leu Ala Asp Ser Ala Ala Ala 
    290                 295                 300                 


Gly Arg Leu Lys Thr Asn Asp Lys Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ser Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  17
<211>  1320
<212>  DNA
<213>  Streptomyces alboniger

<400>  17
atggcgcatc agcagcagga tcccggtcgc gacgcactga tcacgggcat gggattcgcc       60

ctgcccggcc caggaggact gtgcgcgacg tccgcgcaat tcctggacat cgtctccacc      120

ggcgcctgct acgtggagaa tgacggcgtc ttcttcggtc aagtgcgcac cgatatcgcg      180

gatgtgaagg agcgttatcc cgaacttccc gtaaaggctc tgaaactcta ttccccggtg      240

cagttgctcg gcctgatctc catggccgag gcgtgcggtg acgccggact cgactggcgc      300

tcgggcgccc tgtcgcaagc ggcgatcctc gcagcccggg acggcggcga ctgctggtcg      360

gcgcagtacg ccgacatcct caacaccgat cgcacccaag ccaccaagga cgagatcaac      420

gaactgggca cccgtctcgc cctgaccggc atccccatgg acgtggccaa cgtccaggtg      480

tcggtcgtgg ccgggaccgg ccccaacttc accgtctcca acggctgtac gtcctccgcg      540

gtgctcctgg gcatggcggg ccggatgatc gccgacggtg aggtggaggt cgcggtggtc      600

accggcgccg acgtgttcgg cctcggcttc ctgcggcact acgccgacct cctcgaccgg      660

tacgccgagc tgagcgccga ggagggcatc accgtcgacg ccatggagga cgccgcactg      720

gcgatgggcg cgcagatgcg cccgtacgac aagaactccc cgggctccaa catgggcaac      780

ggctccatca cgctcgtcgt ggagagccgc gcgcatgccg agcggcgcgg cgcgaccccc      840

tactcccgaa tgctggcgca gcgcacccgg cgcagcccgc agcacagcgc cttcgccatc      900

gaccgtgcgg ggaccggcat ggtccaggcc tcccgggacg ccatggcggg cctcgtcgag      960

gccgaacaga tcgactacgt caacggaggg gccgagggcg accgcgtctt tcacgagacg     1020

gagtcgaaca tcatgcgcag cctcttcggg gaccgcgcga ccgcgatgcc cgtcaccgtg     1080

caggaggcct gcttcgggca caacggcggt ccgctcggcg ctctgggagt ggcggccacg     1140

tccctgatga tccagcgcga cctggtgttc ccgacggccg gctgcgtcga cccggacgac     1200

acctgcctct tcgacccggt gccgggcacc accgcccggc cactgcgcat cgatcacgcg     1260

ctctccttca actacaccgt cggcatggtc agcagcgcga tcctgctggg gaaggcgtga     1320


<210>  18
<211>  439
<212>  PRT
<213>  Streptomyces alboniger

<400>  18

Met Ala His Gln Gln Gln Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Asp Ile Val Ser Thr Gly Ala Cys Tyr Val Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Lys Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Gly Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Gln Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Gln Tyr Ala Asp Ile Leu Asn 
        115                 120                 125             


Thr Asp Arg Thr Gln Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala Gly Arg Met Ile Ala Asp 
            180                 185                 190         


Gly Glu Val Glu Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Gly Phe Leu Arg His Tyr Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Ile Thr Val Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Gln Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ser Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Ala Glu Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Asn Ile Met Arg Ser Leu Phe Gly Asp Arg 
            340                 345                 350         


Ala Thr Ala Met Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Leu Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Gly Thr Thr Ala Arg Pro Leu Arg 
                405                 410                 415     


Ile Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  19
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamF polypeptide

<400>  19

Met Ala His Gln Gln Gln Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Leu Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Glu Ile Val Ser Thr Gly Ala Cys Tyr Val Glu Asn Asp 
        35                  40                  45              


Gly Leu Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Lys Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Ala Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Phe Arg Ser Gly Ala Leu Ser Gln Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Gln Tyr Ala Asp Ile Leu Gln 
        115                 120                 125             


Thr Asp Arg Thr Gln Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Met Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala Ala Arg Met Ile Ala Asp 
            180                 185                 190         


Gly Glu Val Glu Leu Ala Val Val Thr Gly Ala Asp Val Phe Ala Leu 
        195                 200                 205             


Gly Phe Leu Arg His Tyr Ala Asp Leu Val Asp Lys Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Asp Glu Gly Ile Thr Met Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Gln Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Asn His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Ser Gly Met Val Gln Ala Ser Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Ala Glu Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Lys Val 
                325                 330                 335     


Phe His Glu Thr Glu Thr Asn Ile Met Arg Ser Leu Phe Gly Glu Lys 
            340                 345                 350         


Ala Thr Ala Leu Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Val Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Leu Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Gly Thr Thr Ala Arg Pro Leu Arg 
                405                 410                 415     


Ile Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  20
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamF polypeptide

<400>  20

Met Ala His Gln Gln Gln Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Val Pro Gly Pro Ala Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Asp Ile Val Ser Thr Gly Ala Cys Tyr Val Glu Asn Asp 
        35                  40                  45              


Gly Ile Trp Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Arg Ala Leu Lys Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Asn Leu Leu Gly Leu Leu Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Gly Leu Ser Gln Ala Ala Ile Ile Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Glu Cys Trp Ser Ala Gln Tyr Ala Asp Ile Leu Asn 
        115                 120                 125             


Ser Asp Arg Thr Gln Ala Thr Lys Asp Glu Leu Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Leu Leu Leu Gly Met Ala Gly Arg Met Ile Ala Asp 
            180                 185                 190         


Gly Glu Val Glu Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Val 
        195                 200                 205             


Gly Tyr Leu Arg His Tyr Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Ile Thr Val Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Gln Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Thr Gly Leu Val Gln Ala Ser Arg Asp Ala Met Ala Gly Leu Val Asp 
305                 310                 315                 320 


Ala Asp Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Gln Ile Met Arg Ser Leu Phe Gly Glu Arg 
            340                 345                 350         


Ala Thr Ala Met Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Leu Val Phe Pro Thr Ala Gly Cys Val Glu Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Gly Thr Thr Gly Arg Pro Leu Arg 
                405                 410                 415     


Ile Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  21
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamF polypeptide

<400>  21

Met Ala His Gln Gln Asn Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Ala Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Asp Ile Val Ser Thr Gly Ala Cys Tyr Val Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Arg Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Ala Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Thr Asn Ala Ala Ile Ile Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Asn Tyr Ala Asp Leu Met Asn 
        115                 120                 125             


Thr Asp Arg Thr Gln Ala Ser Lys Asp Glu Met Asn Glu Ile Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Leu Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala Gly Arg Leu Ile Ala Asp 
            180                 185                 190         


Gly Asp Val Glu Met Ala Val Val Thr Gly Ala Asp Leu Phe Gly Leu 
        195                 200                 205             


Ala Phe Leu Arg His Tyr Ala Asp Leu Met Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Ala Ile Thr Val Asp Gly Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Gly Gln Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ser Arg Asp Ala Met Ala Gly Leu Val Asp 
305                 310                 315                 320 


Ala Glu Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Asn Ile Met Lys Ser Val Phe Gly Asp Arg 
            340                 345                 350         


Ala Thr Ala Met Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Val Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ile Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Gly Ser Thr Ala Lys Pro Leu Arg 
                405                 410                 415     


Ile Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Arg Ala 
        435                 


<210>  22
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamF polypeptide

<400>  22

Met Ala His Gln Gln Gln Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Ile Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Asp Ile Val Ser Thr Gly Ala Cys Tyr Leu Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Asn Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Arg Ala Leu Arg Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Ala Leu Val Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Ile Asp Trp Arg Thr Gly Ala Leu Ser Gln Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Phe Ser Ala Gln Phe Ala Asp Leu Ile Asn 
        115                 120                 125             


Thr Asp Arg Thr Gln Ala Ser Lys Asp Glu Val Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Val Pro Met Asp Val Ala Gln Leu Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala Gly Arg Met Ile Ala Asp 
            180                 185                 190         


Gly Glu Val Glu Val Ala Val Val Thr Gly Ala Asp Val Tyr Gly Val 
        195                 200                 205             


Gly Tyr Val Arg His Tyr Ala Asp Leu Val Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Ile Thr Val Glu Ala Ile Glu Glu Ala Ala Leu 
225                 230                 235                 240 


Gly Met Ala Gly Gln Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Thr 
                245                 250                 255     


Asn Ile Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Gly His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Trp Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Ser Gly Met Val Gln Ala Ser Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Ala Glu Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Lys Val 
                325                 330                 335     


Phe His Asp Thr Glu Ser Asn Ile Met Arg Thr Leu Phe Gly Asp Arg 
            340                 345                 350         


Ala Ser Ala Met Pro Val Thr Val Asn Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Met Val Phe Pro Thr Ala Gly Cys Val Glu Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Ala Thr Thr Ala Arg Pro Leu Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Arg Ala 
        435                 


<210>  23
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamF polypeptide

<400>  23

Met Ala His Gln Gln Asn Asp Pro Gly Arg Asp Ala Leu Ile Thr Gly 
1               5                   10                  15      


Ile Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Gln Phe Leu Glu Met Val Ser Thr Gly Ala Cys Tyr Ile Asp Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Ala Gln Val Lys Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Lys Val Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Ala Leu Val Ser Met Ala Glu Ala Cys Gly Glu Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Gln Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Gly Gln Tyr Gly Glu Ile Leu Gln 
        115                 120                 125             


Thr Asp Arg Thr Gln Ala Thr Lys Asp Glu Ile Asn Glu Ile Ala Thr 
    130                 135                 140                 


Arg Met Ala Leu Thr Gly Leu Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Leu Val Ala Gly Thr Gly Pro Asn Tyr Ser Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala Ala Arg Leu Ile Ala Asp 
            180                 185                 190         


Gly Asp Val Glu Leu Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Gly Phe Leu Arg His Tyr Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Gly Glu Glu Gly Ile Thr Leu Asp Ala Met Glu Glu Ala Gly Leu 
225                 230                 235                 240 


Ala Met Gly Ala Gln Met Arg Pro Tyr Asp Arg Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Asn Gly Ser Ile Thr Leu Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ser Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ala Gly 
    290                 295                 300                 


Thr Gly Leu Ile Gln Ala Ser Arg Asp Ala Met Gly Gly Leu Val Glu 
305                 310                 315                 320 


Ala Asp Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Gln Ile Met Arg Ser Val Phe Gly Glu Arg 
            340                 345                 350         


Ala Thr Ala Met Pro Val Thr Val Gln Glu Gly Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Ala Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Val Val Phe Pro Thr Ala Gly Cys Val Glu Pro Asp Asp 
385                 390                 395                 400 


Thr Cys Leu Phe Asp Pro Val Pro Gly Thr Thr Ala Arg Pro Met Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  24
<211>  1338
<212>  DNA
<213>  Streptomyces alboniger

<400>  24
atggctgcac aggctgaatc cgctgcacgg aaaaaccgcg gggactccgt actcgtcacc       60

ggtatcggcg tcatgctccc cggcgcgacc catgtcaacg aattctggca ggacgtgcgc      120

gacggcaatt cacgactcgg ccggctgacg cgctgcgtac cgggcaggac cggggtacgc      180

gtggccggcg agctgcgcga cttcgaccac cggaagttcc tgccggagct gaacgagaag      240

ttcgcgggcc ggtacacgcg cgacgcgctg gtgaccatgt cggccgtcga ggaggcccgc      300

cgtgacgcgg gtctcgggtc cggcgagatc gacccgctgc gcctctccct catcgcctcg      360

tcctcacgcg gccccctgga gtgggtcagc caggcgctgc gggaggacga cagcgtcggc      420

aacagagaag gccacgaaga ccacgaggcg ggcagcacgg cccacttcgg tgacagcggc      480

gccatgctgc gcggcatgcc gggcgccccg gcgacgctgt cggccatcta cggcgacgtg      540

cgcggactcg tcaccacgct cagctccgcc tgcgtgggcg ggcaccacgc catcggcttc      600

gccgccgacc tcattcgcgc gggcaccgcc gacgccgtgg tcgtggtggg ctacgaattc      660

cccctgaccc ccctggtgtt ccagtccttc caggcgatgg gcgaccgcgt cctgtcggcc      720

gagtcggccg acccccgccg cgcgatccgc ccctacaccc gcgaccgcga gggcttcgcc      780

ttcggcgagg gcgccgtcgc cctgtgcctg gagcgggaga gccatgcccg ggcacgcggc      840

gcgggcggct acgcccgctt cctgtcccac agggcgctga acgaggcaac ccaccccttc      900

ggcatggaca tgagcgggca gatcaccgcg tccgccgtcg ccggggcgct ccaggacgcg      960

ggccgcaccc cgcgggacgt cgactggttc tgcgcgcacg gcaccgccac gccgaagaac     1020

gacgtggccg agagccgcat gctcggtgcc ctgtacgagg gccgcccgcg gtccgcctgg     1080

ccgcccctca gctccgtcaa gccggtgtac ggccacctcc tgggcgccgc cgccctggtc     1140

aacgcggcgg ccacctcgct ggccctgcac caccagtgcc tgtgctcgac cgccaactac     1200

gcggacgccg tgcccgaccc ggagtgcgac cacgaccacg tcgccgaggg ggcccgcgcg     1260

acccgcaccg aactcgcggt gtcgctggcc ttcgccatcg gcagccagac ctcggtactg     1320

gcactcggcg ccgcatga                                                   1338


<210>  25
<211>  445
<212>  PRT
<213>  Streptomyces alboniger

<400>  25

Met Ala Ala Gln Ala Glu Ser Ala Ala Arg Lys Asn Arg Gly Asp Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Ile Gly Val Met Leu Pro Gly Ala Thr His Val 
            20                  25                  30          


Asn Glu Phe Trp Gln Asp Val Arg Asp Gly Asn Ser Arg Leu Gly Arg 
        35                  40                  45              


Leu Thr Arg Cys Val Pro Gly Arg Thr Gly Val Arg Val Ala Gly Glu 
    50                  55                  60                  


Leu Arg Asp Phe Asp His Arg Lys Phe Leu Pro Glu Leu Asn Glu Lys 
65                  70                  75                  80  


Phe Ala Gly Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Glu Ala Arg Arg Asp Ala Gly Leu Gly Ser Gly Glu Ile Asp Pro 
            100                 105                 110         


Leu Arg Leu Ser Leu Ile Ala Ser Ser Ser Arg Gly Pro Leu Glu Trp 
        115                 120                 125             


Val Ser Gln Ala Leu Arg Glu Asp Asp Ser Val Gly Asn Arg Glu Gly 
    130                 135                 140                 


His Glu Asp His Glu Ala Gly Ser Thr Ala His Phe Gly Asp Ser Gly 
145                 150                 155                 160 


Ala Met Leu Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala Ile 
                165                 170                 175     


Tyr Gly Asp Val Arg Gly Leu Val Thr Thr Leu Ser Ser Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala Gly 
        195                 200                 205             


Thr Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr Pro 
    210                 215                 220                 


Leu Val Phe Gln Ser Phe Gln Ala Met Gly Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Glu Ser Ala Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp Arg 
                245                 250                 255     


Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe Leu 
        275                 280                 285             


Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp Met 
    290                 295                 300                 


Ser Gly Gln Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Asp Ala 
305                 310                 315                 320 


Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu Tyr 
            340                 345                 350         


Glu Gly Arg Pro Arg Ser Ala Trp Pro Pro Leu Ser Ser Val Lys Pro 
        355                 360                 365             


Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Asp Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Arg Thr Glu Leu Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
        435                 440                 445 


<210>  26
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamA polypeptide

<400>  26

Met Ala Ala Gln Ala Asp Ser Ala Ala Arg Lys Asn Arg Gly Asp Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Leu Gly Val Leu Leu Pro Ala Ala Thr His Val 
            20                  25                  30          


Asn Glu Phe Trp Asn Asp Val Arg Asp Gly Asn Ser Arg Leu Gly Lys 
        35                  40                  45              


Leu Thr Arg Cys Val Pro Gly Arg Ser Gly Val Arg Val Ala Gly Glu 
    50                  55                  60                  


Leu Lys Glu Phe Asp His Arg Lys Phe Leu Pro Glu Leu Asn Glu Lys 
65                  70                  75                  80  


Phe Ala Gly Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Glu Ala Arg Lys Asp Ala Gly Leu Gly Ser Gly Glu Ile Glu Pro 
            100                 105                 110         


Leu Arg Leu Ser Leu Ile Ala Ser Ser Ser Arg Gly Pro Leu Glu Trp 
        115                 120                 125             


Val Ser Gln Ala Leu Arg Glu Asp Asp Ser Val Gly Asn Arg Glu Gly 
    130                 135                 140                 


His Glu Asp His Glu Ala Gly Ser Thr Ala His Phe Gly Glu Ser Ala 
145                 150                 155                 160 


Ala Met Leu Arg Gly Met Pro Gly Ala Pro Ala Ser Leu Ser Ala Ile 
                165                 170                 175     


Tyr Gly Asp Val Arg Gly Leu Val Thr Thr Leu Ser Ser Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala Gly 
        195                 200                 205             


Ser Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr Pro 
    210                 215                 220                 


Leu Val Phe Gln Ser Phe Gln Ala Leu Gly Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Glu Ser Ala Asp Pro Arg Arg Ala Leu Arg Pro Tyr Thr Lys Asp Arg 
                245                 250                 255     


Glu Gly Trp Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Lys Ala Arg Gly Ala Gly Gly Tyr Ala Lys Phe Val 
        275                 280                 285             


Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp Met 
    290                 295                 300                 


Ser Gly Gln Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Asp Ala 
305                 310                 315                 320 


Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu Tyr 
            340                 345                 350         


Glu Gly Arg Pro Arg Ser Ala Phe Pro Pro Leu Ser Ser Val Lys Pro 
        355                 360                 365             


Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Asp Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Arg Thr Glu Leu Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
        435                 440                 445 


<210>  27
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamA polypeptide

<400>  27

Met Ala Ala Gln Ala Glu Ser Ala Ala Arg Lys Asn Arg Gly Asp Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Ile Gly Val Met Leu Pro Gly Ala Thr His Val 
            20                  25                  30          


Asn Glu Phe Trp Gln Asp Val Lys Asp Gly Asn Thr Arg Leu Gly Arg 
        35                  40                  45              


Leu Thr Arg Cys Val Pro Gly Arg Ser Gly Val Arg Ile Gly Gly Glu 
    50                  55                  60                  


Leu Arg Asp Phe Asp His Arg Lys Phe Leu Pro Glu Leu Asn Glu Lys 
65                  70                  75                  80  


Phe Ala Gly Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Glu Ala Arg Lys Asp Ala Gly Ile Gly Ser Gly Glu Val Glu Pro 
            100                 105                 110         


Leu Arg Leu Ser Leu Ile Ala Ser Ser Ser Arg Gly Pro Leu Glu Trp 
        115                 120                 125             


Val Ser Gln Ala Leu Arg Glu Asp Asp Ser Val Gly Asn Arg Asp Gly 
    130                 135                 140                 


His Glu Asp His Glu Ala Gly Ser Thr Ala His Phe Gly Asp Ser Gly 
145                 150                 155                 160 


Ala Met Leu Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala Leu 
                165                 170                 175     


Tyr Gly Asp Val Arg Gly Leu Val Thr Thr Leu Ser Ser Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala Gly 
        195                 200                 205             


Thr Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Met Thr Pro 
    210                 215                 220                 


Leu Val Phe Gln Ser Phe Gln Ala Met Gly Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Glu Ser Ala Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp Arg 
                245                 250                 255     


Asp Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe Leu 
        275                 280                 285             


Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp Leu 
    290                 295                 300                 


Ser Gly Asn Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Asp Ala 
305                 310                 315                 320 


Gly Arg Ser Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Ala Ala Val Tyr 
            340                 345                 350         


Glu Ala Arg Pro Arg Ser Ala Trp Pro Pro Leu Ser Ser Leu Lys Pro 
        355                 360                 365             


Leu Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Asp Ala Val Pro Asp Pro Glu Cys Asp His Glu His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Arg Thr Glu Leu Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Asn Thr Ser Val Leu Ala Leu Gly Ala Ala 
        435                 440                 445 


<210>  28
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamA polypeptide

<400>  28

Met Ala Ala Gln Ala Glu Ser Ala Ala Arg Lys Asn Arg Gly Asp Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Met Gly Val Val Met Pro Gly Ala Thr His Val 
            20                  25                  30          


Asn Glu Phe Trp Gln Asp Val Arg Asp Gly Asn Ser Arg Ile Gly Arg 
        35                  40                  45              


Ile Thr Arg Cys Val Pro Gly Lys Thr Gly Val Arg Ile Ala Gly Glu 
    50                  55                  60                  


Leu Arg Asp Phe Asp His Lys Lys Phe Leu Pro Glu Leu Asn Glu Lys 
65                  70                  75                  80  


Phe Ala Ala Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Glu Ala Arg Arg Asp Ala Gly Leu Gly Ser Gly Glu Ile Glu Pro 
            100                 105                 110         


Leu Arg Val Ser Leu Ile Ala Ser Ser Ser Arg Gly Pro Leu Glu Trp 
        115                 120                 125             


Leu Ser Asn Ala Leu Arg Glu Asp Asp Ser Val Gly Asn Arg Glu Gly 
    130                 135                 140                 


His Glu Asp His Glu Ala Gly Ser Thr Ala His Trp Gly Asp Ser Gly 
145                 150                 155                 160 


Ala Met Ile Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala Ile 
                165                 170                 175     


Tyr Gly Asp Val Lys Gly Leu Val Thr Thr Leu Ser Ser Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Met Ile Lys Ala Gly 
        195                 200                 205             


Thr Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Ser Pro 
    210                 215                 220                 


Leu Val Tyr Gln Ser Phe Gln Ala Ile Ala Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Glu Ser Ala Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Lys Asp Arg 
                245                 250                 255     


Asp Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe Leu 
        275                 280                 285             


Ser His Arg Ala Leu Gln Glu Ala Thr His Pro Phe Gly Met Asp Met 
    290                 295                 300                 


Ser Gly Gln Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Asp Ala 
305                 310                 315                 320 


Gly Arg Thr Pro Lys Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Val Ala Glu Ser Lys Met Leu Gly Ala Leu Tyr 
            340                 345                 350         


Glu Gly Arg Pro Arg Ser Ala Trp Pro Pro Leu Ser Ser Leu Lys Pro 
        355                 360                 365             


Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Asp Gly Val Pro Asp Pro Glu Cys Asp His Glu His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Arg Thr Glu Val Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Asn Thr Ser Val Leu Ala Leu Gly Ala Ala 
        435                 440                 445 


<210>  29
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamA polypeptide

<400>  29

Met Ala Ala Gln Ala Glu Thr Ala Ala Arg Lys Asn Arg Gly Asp Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Ile Gly Val Val Leu Pro Gly Ala Thr His Leu 
            20                  25                  30          


Asn Glu Phe Trp Gln Asp Val Arg Asp Gly Asn Ser Arg Val Gly Arg 
        35                  40                  45              


Ile Thr Arg Cys Val Pro Gly Lys Ser Ala Val Arg Leu Ala Gly Glu 
    50                  55                  60                  


Leu Lys Asp Phe Asp His Lys Arg Phe Leu Pro Glu Leu Asn Glu Arg 
65                  70                  75                  80  


Phe Ala Gly Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Glu Ala Arg Arg Asp Ala Gly Leu Gly Ser Ala Asp Leu Asp Pro 
            100                 105                 110         


Leu Arg Ile Ser Leu Leu Ala Ser Ser Ser Arg Gly Pro Leu Asp Trp 
        115                 120                 125             


Leu Ser Gln Ala Leu Lys Glu Asp Asp Ser Val Gly Gln Arg Glu Gly 
    130                 135                 140                 


His Glu Asp His Glu Ala Ala Ser Thr Ala His Tyr Gly Glu Ser Ala 
145                 150                 155                 160 


Ala Leu Met Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala Ile 
                165                 170                 175     


Tyr Gly Asp Val Arg Gly Leu Val Thr Thr Leu Ser Thr Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Val Ile Arg Ala Gly 
        195                 200                 205             


Thr Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Met Ser Pro 
    210                 215                 220                 


Ile Val Phe Gln Ser Phe Gln Ala Met Gly Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Glu Ser Ala Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp Arg 
                245                 250                 255     


Asp Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe Leu 
        275                 280                 285             


Ser His Arg Ala Leu Asn Glu Ala Ser His Pro Phe Ala Met Asp Met 
    290                 295                 300                 


Ser Gly Gln Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Glu Ala 
305                 310                 315                 320 


Gly Arg Ser Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu Tyr 
            340                 345                 350         


Glu Gly Arg Pro Lys Ser Ala Tyr Pro Pro Leu Ser Ser Val Lys Pro 
        355                 360                 365             


Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Gln Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Glu Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Lys Thr Glu Ile Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Gly Ala 
        435                 440                 445 


<210>  30
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamA polypeptide

<400>  30

Met Ala Ala Gln Ala Glu Ser Ala Ala Arg Arg Asn Lys Gly Glu Ser 
1               5                   10                  15      


Val Leu Val Thr Gly Ile Gly Ile Met Leu Pro Gly Ala Thr His Leu 
            20                  25                  30          


Asn Glu Phe Trp Gln Asp Val Arg Glu Gly Gln Ser Arg Leu Gly Arg 
        35                  40                  45              


Val Thr Arg Cys Val Pro Gly Arg Thr Gly Val Arg Ile Ala Gly Glu 
    50                  55                  60                  


Leu Arg Asp Phe Asp His Arg Lys Phe Val Pro Asp Leu Asn Glu Lys 
65                  70                  75                  80  


Phe Ala Gly Arg Tyr Thr Arg Asp Ala Leu Val Thr Met Ser Ala Val 
                85                  90                  95      


Glu Asp Ala Arg Arg Asp Ala Gly Leu Gly Ser Gly Glu Leu Glu Pro 
            100                 105                 110         


Leu Arg Leu Ser Leu Val Ala Ser Ser Ser Arg Gly Pro Val Glu Trp 
        115                 120                 125             


Ile Thr Gln Ala Ile Lys Glu Glu Asp Ser Val Gly Asn Arg Asp Gly 
    130                 135                 140                 


His Glu Glu His Glu Ala Gly Thr Thr Ala His Phe Gly Asp Thr Ala 
145                 150                 155                 160 


Ala Met Val Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala Ile 
                165                 170                 175     


Tyr Gly Asp Val Arg Gly Leu Val Ser Thr Leu Ser Ser Ala Cys Val 
            180                 185                 190         


Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala Gly 
        195                 200                 205             


Thr Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr Pro 
    210                 215                 220                 


Leu Leu Tyr Gln Ser Phe Gln Gly Leu Gly Asp Arg Val Leu Ser Ala 
225                 230                 235                 240 


Asp Ser Ala Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Lys Asp Arg 
                245                 250                 255     


Asp Gly Tyr Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu Arg 
            260                 265                 270         


Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe Leu 
        275                 280                 285             


Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Glu Met 
    290                 295                 300                 


Ser Gly Gln Ile Thr Ala Ser Ala Val Ala Gly Ala Leu Gln Glu Ala 
305                 310                 315                 320 


Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr Ala 
                325                 330                 335     


Thr Pro Lys Asn Asp Leu Ala Glu Ser Arg Met Leu Ala Ala Val Tyr 
            340                 345                 350         


Glu Gly Arg Pro Lys Ser Ala Trp Pro Pro Leu Ser Ser Val Lys Pro 
        355                 360                 365             


Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Leu Asn Ala Ala Ala 
    370                 375                 380                 


Thr Ser Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn Tyr 
385                 390                 395                 400 


Ala Asp Ala Val Pro Asp Pro Glu Cys Asp His Glu His Val Ala Glu 
                405                 410                 415     


Gly Ala Arg Ala Thr Arg Ser Glu Leu Ala Val Ser Leu Ala Phe Ala 
            420                 425                 430         


Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
        435                 440                 445 


<210>  31
<211>  1863
<212>  DNA
<213>  Streptomyces alboniger

<400>  31
atgaccggtg ccgaacccgc gcggaccgaa cccctgaagg agaccatgag cacgcacagc       60

ggcaccgcgc cacgccccga catcgtccct gacgtcgtcc ccgacgtcga ctccctggtg      120

tcccggtacg tgacgccggg gatgcatctg cacctggcca tgacgatggc gcggcccaac      180

gccatggtct acgcgctggc acggcggttc gcgggccgcg gcgagttcac cgtcagcacg      240

tcggccacgc acacggccat gcacgcgctg accatgtcgg gcgcggtcag gcatctgatc      300

acctgcttcc tcggtgacac ctaccccacg ccgcgcccca acccgctcta ccgcgacctg      360

gcccgcggca tccccttcac ctgcgagttg tggtccctgc tcagcttcac ccagcgcctg      420

atggccgggg ccacggggct gccgtacgcc gtgacgtcct cgctcatcgg cagcgatctg      480

gagcgcggtc tcaccggcga cggccccggg acacgcccgc tgccggaggg cgaacagccg      540

ctcggcggac cgaagttcct gcgcctgccc ggccggtcgg ccgaagagcg cccgttcggt      600

ctcgtggagc ggctgcgtcc ggacctcacc ctggtgcacg gcgcctgcgc ggaccggcgc      660

ggcaacatcg tcctcgtgcc gcccgcgggc gagggcgcct gggccgcgta cgccgccgaa      720

cagggcgtgc tcgcctcggt ggagcgcatc gtgcccgacg acttcaccga cgggcacccc      780

gaacggatcg tcattcccgg ccggcgcgtg ctcgccctgt gcgaggcgcc gctgggcgcg      840

cacccgcagt cgctgcgcgg tctcgccacc ggcgacgagc gcggcgacgt gagcgggtac      900

cgcgacgact acgccttcct caccgagctg gtggaccggc tggccaccga ggacggcgcc      960

aaggagtggt accgcgagtg ggtggaggag cccgccgggc acgcgcagta cgtacgcaag     1020

ctgggcgagg cgcgccgcgc cgaactgacc ctcgcctcgg ggccgctcac ctctcgcgag     1080

cccgccactc ccccggtgcc gctccccgcg ggagccatcg ccgccgagcc cgtgacgcgc     1140

caggagcgga ccatcgtcct gggcgcccgc gccatcgccg accgggtcac gcgcgacggc     1200

tacgacaccc tgctcgcggg catcggcgtc tcccacctgg ccgcctggct cgccgccgcg     1260

ctcctgcgcg aacagggcgt gcgggtgccg gtctgcgccg agctgggctt ctacggcatg     1320

gaccccgagc ccggcgacgt cttcctcttc agccagctgc acgccacgcg ttcccagcag     1380

ctcgtgggca tccccgagat cctcggcggc atggtgtcgg cgaacccgcg ctgcctgggc     1440

gtcctggccg ccggtgaggt cgacgcggac ggcaacgtca acaccagcct gctggccgac     1500

ggacgctggc tgaccggctc cggcggcgcc aacgacatcg cgacgagcac cgactgcctg     1560

gtgctgtcca cggcttcccc gcgcaagttc gtcgagcggg tcgcctatgt caccagtccc     1620

ggtgcccgcg tacgggaagt ggtcagccac ttcgggcggt tccggcgcga gcaggacaca     1680

cggggggcct tccgcctcgc cacctggctg ccgctcaacg acggcccggc ctcccccgag     1740

gaggccgtgg cggcgctgac ccgctggccg gtgagcggcg cgggctgcac ggcggaaccg     1800

caggtcaccg aggcggagat cgcctggctg cgcagtctcg atccgcaagg tttctacagg     1860

tga                                                                   1863


<210>  32
<211>  620
<212>  PRT
<213>  Streptomyces alboniger

<400>  32

Met Thr Gly Ala Glu Pro Ala Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Thr His Ser Gly Thr Ala Pro Arg Pro Asp Ile Val Pro Asp Val 
            20                  25                  30          


Val Pro Asp Val Asp Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Leu Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Ala Arg Arg Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr 
65                  70                  75                  80  


Ser Ala Thr His Thr Ala Met His Ala Leu Thr Met Ser Gly Ala Val 
                85                  90                  95      


Arg His Leu Ile Thr Cys Phe Leu Gly Asp Thr Tyr Pro Thr Pro Arg 
            100                 105                 110         


Pro Asn Pro Leu Tyr Arg Asp Leu Ala Arg Gly Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Leu Trp Ser Leu Leu Ser Phe Thr Gln Arg Leu Met Ala Gly Ala 
    130                 135                 140                 


Thr Gly Leu Pro Tyr Ala Val Thr Ser Ser Leu Ile Gly Ser Asp Leu 
145                 150                 155                 160 


Glu Arg Gly Leu Thr Gly Asp Gly Pro Gly Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Leu Gly Gly Pro Lys Phe Leu Arg Leu Pro Gly Arg 
            180                 185                 190         


Ser Ala Glu Glu Arg Pro Phe Gly Leu Val Glu Arg Leu Arg Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Arg Gly Asn Ile Val 
    210                 215                 220                 


Leu Val Pro Pro Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Glu 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Thr 
                245                 250                 255     


Asp Gly His Pro Glu Arg Ile Val Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Gly Leu 
        275                 280                 285             


Ala Thr Gly Asp Glu Arg Gly Asp Val Ser Gly Tyr Arg Asp Asp Tyr 
    290                 295                 300                 


Ala Phe Leu Thr Glu Leu Val Asp Arg Leu Ala Thr Glu Asp Gly Ala 
305                 310                 315                 320 


Lys Glu Trp Tyr Arg Glu Trp Val Glu Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Val Arg Lys Leu Gly Glu Ala Arg Arg Ala Glu Leu Thr Leu Ala 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Glu Pro Ala Thr Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Gly Ala Ile Ala Ala Glu Pro Val Thr Arg Gln Glu Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Arg Ala Ile Ala Asp Arg Val Thr Arg Asp Gly 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Val Arg Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Leu Val Gly Ile 
    450                 455                 460                 


Pro Glu Ile Leu Gly Gly Met Val Ser Ala Asn Pro Arg Cys Leu Gly 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Leu Leu Ala Asp Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Thr Ser Thr Asp Cys Leu Val Leu Ser Thr Ala Ser Pro Arg 
        515                 520                 525             


Lys Phe Val Glu Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val 
    530                 535                 540                 


Arg Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Glu Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Arg Leu Ala Thr Trp Leu Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Gly Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Glu Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  33
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamB polypeptide

<400>  33

Met Thr Gly Ala Glu Pro Ala Arg Thr Asp Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Thr His Ser Gly Thr Ala Pro Arg Pro Asp Met Val Pro Asp Val 
            20                  25                  30          


Val Pro Asp Ile Asp Ser Leu Val Ser Arg Phe Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Ile Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Ala Lys Arg Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr 
65                  70                  75                  80  


Ser Ala Thr His Thr Ala Met His Ala Leu Thr Met Thr Gly Ala Val 
                85                  90                  95      


Arg His Leu Ile Thr Cys Phe Val Gly Asp Thr Tyr Pro Thr Pro Arg 
            100                 105                 110         


Pro Asn Pro Val Tyr Arg Asp Leu Ala Arg Gly Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Leu Tyr Ser Leu Leu Ser Phe Thr Gln Arg Leu Met Ala Gly Ala 
    130                 135                 140                 


Thr Gly Leu Pro Tyr Ala Val Thr Ser Ser Leu Leu Gly Ser Asp Leu 
145                 150                 155                 160 


Glu Lys Gly Leu Thr Gly Asp Gly Pro Gly Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Leu Gly Gly Pro Lys Phe Leu Arg Leu Pro Gly Arg 
            180                 185                 190         


Ser Ala Glu Glu Arg Pro Phe Gly Leu Val Glu Arg Leu Arg Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Arg Gly Asn Ile Ile 
    210                 215                 220                 


Leu Val Pro Pro Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Glu 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Thr 
                245                 250                 255     


Asp Gly His Pro Asp Arg Ile Val Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Ile Arg Gly Leu 
        275                 280                 285             


Ala Thr Gly Asp Glu Arg Gly Asp Val Ser Gly Tyr Arg Asp Asp Tyr 
    290                 295                 300                 


Ala Phe Leu Thr Glu Leu Val Asp Arg Leu Ala Thr Glu Asp Gly Ala 
305                 310                 315                 320 


Lys Glu Trp Tyr Lys Glu Trp Val Asp Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Ile Arg Lys Leu Gly Glu Ala Arg Arg Ala Glu Leu Ser Leu Ala 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Glu Pro Ala Thr Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Ala Ala Ile Ala Ala Asp Pro Met Ser Arg Gln Glu Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Arg Ala Ile Ala Asp Arg Val Thr Arg Asp Gly 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Val Lys Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Phe Tyr Gly Leu Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Leu Val Gly Ile 
    450                 455                 460                 


Pro Asp Ile Leu Gly Gly Met Val Ser Ala Asn Pro Arg Cys Val Gly 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Gly Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Leu Leu Ala Glu Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Thr Ser Thr Asp Cys Leu Val Leu Ser Thr Ala Thr Pro Lys 
        515                 520                 525             


Lys Phe Val Glu Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val 
    530                 535                 540                 


Arg Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Glu Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Arg Leu Ala Thr Trp Leu Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Gly Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Glu Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  34
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamB polypeptide

<400>  34

Met Thr Gly Ala Glu Pro Ala Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Thr His Ser Gly Thr Ala Pro Arg Pro Asp Met Val Pro Asp Val 
            20                  25                  30          


Val Pro Asp Val Glu Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Val Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Ala Arg Arg Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Thr His Thr Ala Met His Ala Leu Thr Met Ser Gly Ala Val 
                85                  90                  95      


Arg His Leu Ile Thr Cys Phe Val Gly Asp Thr Tyr Pro Thr Pro Arg 
            100                 105                 110         


Pro Asn Pro Val Tyr Arg Asp Leu Ala Arg Gly Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Met Trp Ser Leu Leu Ser Phe Thr Gln Lys Leu Met Ala Gly Ala 
    130                 135                 140                 


Thr Gly Leu Pro Tyr Ala Val Thr Ser Ser Leu Ile Gly Ser Asp Leu 
145                 150                 155                 160 


Glu Arg Gly Leu Thr Gly Asp Ala Pro Ala Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Val Gly Ala Pro Lys Phe Leu Arg Ile Pro Gly Arg 
            180                 185                 190         


Ser Ala Glu Glu Arg Pro Phe Gly Leu Val Glu Arg Leu Lys Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Arg Gly Asn Ile Val 
    210                 215                 220                 


Leu Val Pro Pro Ala Gly Glu Gly Ala Phe Ala Ala Tyr Ala Ala Glu 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Thr 
                245                 250                 255     


Asp Gly His Pro Glu Arg Ile Val Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Ala Pro Val Gly Ala His Pro Gln Ser Leu Arg Gly Leu 
        275                 280                 285             


Ala Thr Gly Asp Glu Arg Gly Asp Val Ser Gly Tyr Arg Asp Asp Tyr 
    290                 295                 300                 


Ala Phe Leu Thr Glu Leu Ile Asp Arg Leu Ala Thr Glu Glu Ala Ala 
305                 310                 315                 320 


Lys Glu Trp Tyr Arg Glu Tyr Val Glu Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Val Arg Lys Ile Gly Glu Ala Arg Arg Gly Glu Leu Ser Leu Ala 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Asp Pro Ala Thr Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Gly Ala Ile Ala Ala Glu Pro Met Thr Arg Gln Glu Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Arg Ala Ile Ala Asp Arg Val Thr Arg Asp Gly 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Leu Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Val Arg Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Leu Val Gly Ile 
    450                 455                 460                 


Pro Glu Ile Leu Gly Gly Met Ile Ser Ala Asn Pro Arg Cys Val Ala 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Leu Leu Ala Asp Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Thr Ser Thr Asp Cys Leu Val Leu Ser Thr Ala Ser Pro Arg 
        515                 520                 525             


Lys Phe Val Glu Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Ile 
    530                 535                 540                 


Arg Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Glu Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Arg Leu Ala Thr Trp Leu Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Ala Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Glu Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  35
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamB polypeptide

<400>  35

Met Thr Gly Ala Glu Pro Ala Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Thr His Ser Gly Thr Ala Pro Arg Pro Asp Ile Val Pro Asp Val 
            20                  25                  30          


Val Pro Asp Val Asp Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Leu Ala Met Thr Met Gly Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Ala Arg Arg Phe Ala Gly Arg Gly Glu Phe Thr Ile Ser Thr 
65                  70                  75                  80  


Ser Ala Thr His Thr Ala Met His Ala Leu Thr Met Thr Gly Ala Val 
                85                  90                  95      


Lys His Leu Ile Thr Cys Phe Leu Gly Glu Thr Tyr Pro Ser Pro Arg 
            100                 105                 110         


Pro Asn Pro Val Tyr Arg Asp Leu Ala Arg Gly Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Leu Trp Ser Leu Leu Ser Phe Thr Gln Arg Leu Met Ala Gly Ala 
    130                 135                 140                 


Ser Gly Ile Pro Tyr Ala Ile Thr Ser Ser Leu Leu Gly Ser Asp Leu 
145                 150                 155                 160 


Glu Arg Gly Leu Thr Gly Asp Gly Pro Gly Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Leu Gly Gly Pro Lys Phe Leu Arg Ile Pro Gly Arg 
            180                 185                 190         


Ser Ala Glu Glu Lys Pro Phe Gly Leu Val Glu Arg Leu Arg Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Lys Gly Asn Ile Val 
    210                 215                 220                 


Leu Val Pro Pro Ala Gly Glu Ala Ala Trp Ala Ala Tyr Ala Ala Glu 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Lys Ile Val Pro Asp Asp Phe Thr 
                245                 250                 255     


Asp Gly His Pro Glu Arg Ile Val Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Ala Ile 
        275                 280                 285             


Ala Thr Gly Asp Glu Arg Gly Asp Val Ser Gly Tyr Arg Asp Asp Tyr 
    290                 295                 300                 


Ala Phe Val Thr Glu Leu Val Asp Arg Leu Ala Thr Glu Asp Gly Ala 
305                 310                 315                 320 


Arg Glu Trp Tyr Arg Glu Tyr Leu Glu Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Leu Arg Lys Ile Gly Asp Gly Arg Arg Ala Asp Leu Ser Leu Ala 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Asp Pro Ala Thr Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Gly Ala Ile Ala Gly Glu Pro Leu Thr Arg Gln Asp Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Lys Ala Ile Ala Asp Arg Val Thr Arg Asp Ala 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Val Arg Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Tyr Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Val Val Gly Ile 
    450                 455                 460                 


Pro Glu Ile Leu Ala Gly Met Val Ser Ala Asn Pro Arg Cys Leu Gly 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Met Ile Ala Asp Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Thr Ser Thr Asp Cys Leu Val Leu Ser Thr Ala Ser Pro Arg 
        515                 520                 525             


Lys Phe Val Glu Lys Val Ala Tyr Val Thr Ser Pro Gly Gly Arg Val 
    530                 535                 540                 


Arg Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Asp Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Arg Leu Ala Thr Trp Leu Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Ala Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Glu Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  36
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamB polypeptide

<400>  36

Met Thr Gly Ala Glu Pro Ala Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Ser His Ser Gly Thr Ala Pro Arg Pro Asp Ile Val Pro Asp Val 
            20                  25                  30          


Leu Pro Asp Leu Asp Ser Leu Leu Ser Arg Tyr Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Leu Ala Met Thr Leu Ala Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Ala Arg Arg Tyr Ala Gly Arg Gly Glu Phe Thr Ile Ser Ser 
65                  70                  75                  80  


Ser Gly Thr His Thr Ala Ile His Ala Leu Thr Met Thr Gly Ala Val 
                85                  90                  95      


Arg His Leu Ile Thr Cys Phe Val Gly Glu Thr Tyr Pro Ser Pro Arg 
            100                 105                 110         


Pro Asn Pro Val Tyr Arg Asp Leu Ala Arg Ala Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Leu Tyr Ser Leu Leu Ser Phe Thr Gln Arg Ile Met Ala Gly Ala 
    130                 135                 140                 


Thr Gly Ile Pro Tyr Ala Val Thr Ser Ser Leu Ile Gly Ser Asp Leu 
145                 150                 155                 160 


Asp Arg Gly Leu Thr Gly Asp Ala Pro Gly Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Leu Ala Gly Pro Lys Phe Leu Lys Val Pro Gly Arg 
            180                 185                 190         


Ser Gly Glu Glu Arg Pro Phe Gly Leu Val Glu Arg Leu Lys Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Arg Gly Asn Ile Val 
    210                 215                 220                 


Leu Leu Pro Pro Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Thr 
                245                 250                 255     


Asp Ala His Pro Asp Arg Ile Val Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Gly Pro Leu Gly Ala His Pro Gln Ser Leu Arg Gly Leu 
        275                 280                 285             


Ala Ser Ala Asp Glu Arg Gly Asp Val Ser Gly Tyr Lys Asp Asp Tyr 
    290                 295                 300                 


Ala Phe Leu Thr Glu Leu Val Asp Arg Leu Ala Thr Glu Glu Gly Ala 
305                 310                 315                 320 


Lys Glu Trp Tyr Arg Glu Trp Ile Glu Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Leu Arg Lys Leu Gly Glu Ala Arg Arg Ala Glu Val Thr Leu Gly 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Glu Pro Ala Ser Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Ala Ala Met Ala Gly Glu Pro Val Thr Arg Gln Glu Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Lys Ala Ile Ala Asp Arg Val Thr Lys Asp Gly 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Leu Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Ile Arg Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Phe Tyr Gly Ile Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Leu Ile Gly Ile 
    450                 455                 460                 


Pro Asp Ile Leu Ala Gly Met Ile Ser Ala Asn Pro Arg Cys Leu Gly 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Val Val Ala Asp Gly Lys Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Thr Ser Thr Asp Cys Leu Val Val Ser Thr Ala Ser Pro Arg 
        515                 520                 525             


Lys Phe Val Glu Lys Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val 
    530                 535                 540                 


Lys Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Asp Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Lys Leu Ala Thr Trp Ile Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Gly Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Asp Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  37
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamB polypeptide

<400>  37

Met Thr Gly Ala Glu Pro Ala Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Ser Thr His Ser Gly Thr Ala Pro Arg Pro Asp Ile Val Pro Asp Val 
            20                  25                  30          


Ile Pro Asp Leu Asp Ser Leu Val Ser Arg Phe Val Thr Pro Gly Met 
        35                  40                  45              


His Leu His Ile Ala Met Thr Leu Ala Arg Pro Asn Ala Met Val Tyr 
    50                  55                  60                  


Ala Leu Gly Arg Arg Tyr Ala Gly Arg Gly Glu Phe Thr Leu Ser Thr 
65                  70                  75                  80  


Ser Gly Thr His Thr Ala Leu His Ala Leu Thr Met Thr Gly Ala Val 
                85                  90                  95      


Lys His Val Ile Thr Cys Phe Leu Gly Asp Thr Tyr Pro Ser Pro Arg 
            100                 105                 110         


Pro Asn Pro Leu Tyr Arg Asp Leu Ala Arg Ala Ile Pro Phe Thr Cys 
        115                 120                 125             


Glu Leu Trp Ser Leu Leu Ser Phe Thr Gln Arg Ile Met Ala Gly Ala 
    130                 135                 140                 


Thr Gly Leu Pro Tyr Ala Ile Thr Ser Ser Leu Leu Gly Ser Asp Leu 
145                 150                 155                 160 


Asp Lys Gly Leu Thr Gly Asp Ala Pro Gly Thr Arg Pro Leu Pro Glu 
                165                 170                 175     


Gly Glu Gln Pro Leu Gly Gly Pro Arg Trp Leu Arg Met Pro Gly Arg 
            180                 185                 190         


Ser Ala Glu Glu Arg Pro Phe Gly Leu Val Glu Arg Leu Arg Pro Asp 
        195                 200                 205             


Leu Thr Leu Val His Gly Ala Cys Ala Asp Arg Arg Gly Asn Ile Ile 
    210                 215                 220                 


Val Val Pro Pro Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp 
225                 230                 235                 240 


Gln Gly Val Leu Ala Ser Val Glu Arg Ile Val Pro Glu Asp Phe Thr 
                245                 250                 255     


Asp Gly His Pro Glu Arg Ile Ile Ile Pro Gly Arg Arg Val Leu Ala 
            260                 265                 270         


Leu Cys Glu Ala Pro Leu Gly Gly His Pro Gln Ser Leu Arg Gly Leu 
        275                 280                 285             


Ala Thr Gly Asp Glu Arg Gly Asp Val Thr Gly Tyr Arg Glu Asp Tyr 
    290                 295                 300                 


Ala Phe Leu Thr Asp Leu Val Glu Arg Leu Ala Thr Glu Asp Ala Ala 
305                 310                 315                 320 


Lys Glu Trp Tyr Arg Glu Trp Leu Glu Glu Pro Ala Gly His Ala Gln 
                325                 330                 335     


Tyr Leu Lys Lys Leu Gly Glu Ala Arg Arg Ala Glu Leu Thr Ile Ala 
            340                 345                 350         


Ser Gly Pro Leu Thr Ser Arg Asp Pro Gly Thr Pro Pro Val Pro Leu 
        355                 360                 365             


Pro Ala Gly Ala Leu Ala Ala Asp Pro Val Thr Arg Gln Asp Arg Thr 
    370                 375                 380                 


Ile Val Leu Gly Ala Arg Ala Ile Gly Asp Arg Val Thr Arg Asp Gly 
385                 390                 395                 400 


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp 
                405                 410                 415     


Leu Ala Ala Ala Leu Leu Arg Glu Gln Gly Val Lys Val Pro Val Cys 
            420                 425                 430         


Ala Glu Leu Gly Phe Tyr Gly Ile Asp Pro Glu Pro Gly Asp Val Phe 
        435                 440                 445             


Leu Phe Ser Gln Leu His Ala Thr Arg Ser Gln Gln Ile Leu Gly Ile 
    450                 455                 460                 


Pro Asp Ile Leu Ala Gly Met Met Ser Ala Asn Pro Arg Cys Val Gly 
465                 470                 475                 480 


Val Leu Ala Ala Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser 
                485                 490                 495     


Ile Leu Ala Asp Gly Arg Trp Val Thr Gly Ser Gly Gly Ala Asn Asp 
            500                 505                 510         


Ile Ala Ser Ser Thr Asp Cys Leu Val Val Thr Thr Ala Ser Pro Arg 
        515                 520                 525             


Lys Phe Val Asp Lys Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val 
    530                 535                 540                 


Arg Glu Val Val Ser His Phe Gly Arg Phe Arg Arg Asp Gln Asp Thr 
545                 550                 555                 560 


Arg Gly Ala Phe Arg Leu Ala Thr Trp Leu Pro Leu Asn Asp Gly Pro 
                565                 570                 575     


Ala Ser Pro Glu Glu Ala Val Ala Ala Leu Thr Arg Trp Pro Val Ser 
            580                 585                 590         


Ala Ala Gly Cys Thr Ala Glu Pro Gln Val Thr Glu Ala Glu Ile Ala 
        595                 600                 605             


Trp Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 620 


<210>  38
<211>  960
<212>  DNA
<213>  Streptomyces alboniger

<400>  38
gtgagcggtg gaatctgggt gggccgcggc ctgtccttcc ggggcttcgg ccactacttc       60

ccgcggcaca gcgaggagat cccggccgac ctgcccgacg cgccggagat ggaggcggcg      120

gtcctcggcc cggacctcgg cgtggagcgg cggcacctgt ccgacgacac ggagagcgtg      180

ccgtacatgg ccgtggaggc cggacggcac gcgttgcgca acgccggcct ggaggcctgc      240

gacctcgacc tggtggtctt ctcctcctgg tcgcagcggc ggtacgcgcc tgaggacggg      300

ccccggatcg cgatgcgcct cggcgccggg cgggccttgg ccttcgacgt gtgcgccgcc      360

tgcgtcggct tcgtccactc cgtgcagacg gccgccgcga tgctgaccag tcaccgctgg      420

cggcacgccc tggtgatctg ctccgaccag ttctcgcgtc ggctcaagcc cggtcggcgg      480

ggttcgtacg tcggcggcga cggggcgggc gcggccgttc tggaggtggg ggcgccggac      540

gagtcccggc tgcgggactc cgtcgtgctc agctacggcg agcacgcggg cgtctccaag      600

gcccgcggca gcgacggctg gacggtgagc ctgcccacga tctcccaggt ggccgccgcg      660

accgcgggcg aggccacgga cctggtgctg cggcgcaacg acatgaccat cgccgatgtg      720

gaccgggtcg tgccgcatcc gggctcggca cggatcagtg aggagctggt gcggcgcatc      780

ggcgtcgccc ccgagcgggt cctgacgaac ctgcggacac gcggccagac gaccagcgcc      840

acgatcccga gcgccctgtc cgagttcacc gagtccggcg aactgcgcaa gggcaacgtg      900

atcctgtcgc ccgcggccgg cgcggggtgg ttctcgggcg ccctgctcta ccagctctga      960


<210>  39
<211>  319
<212>  PRT
<213>  Streptomyces alboniger

<400>  39

Val Ser Gly Gly Ile Trp Val Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Asp Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Asp Asp Thr Glu Ser Val Pro Tyr Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Met Leu Thr Ser His Arg Trp Arg His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Phe Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Gly Ala Pro Asp Glu Ser Arg Leu Arg Asp Ser Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Gly Val Ser Lys Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Thr Ile Ser Gln Val Ala Ala Ala Thr Ala Gly Glu 
    210                 215                 220                 


Ala Thr Asp Leu Val Leu Arg Arg Asn Asp Met Thr Ile Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Leu 
                245                 250                 255     


Val Arg Arg Ile Gly Val Ala Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  40
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamD polypeptide

<400>  40

Val Ser Gly Gly Ile Trp Val Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Asp Ala Pro Glu Met Glu Ala Ala Val Met Ala Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Asp Asp Thr Glu Ser Val Pro Tyr Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Ile Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Arg Ile Ala Met Lys Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Leu Leu Thr Ser His Arg Tyr Arg His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Phe Ser Arg Arg Ile Lys Pro Gly Lys Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Gly Ala Pro Asp Asp Ser Arg Leu Arg Asp Ser Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Asp His Ala Gly Leu Ser Arg Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Met Ser Leu Pro Thr Ile Ser Gln Val Ala Ala Ala Thr Ala Gly Glu 
    210                 215                 220                 


Ala Thr Asp Leu Val Leu Arg Arg Asn Asp Leu Thr Met Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Leu 
                245                 250                 255     


Val Arg Arg Ile Gly Val Ala Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Phe Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  41
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamD polypeptide

<400>  41

Val Ser Gly Gly Ile Trp Val Gly Lys Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Asp Asp Thr Glu Ser Val Pro Tyr Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Asp Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Asn Thr Ala Ala Ala Met Leu Thr Ser His Arg Trp Arg His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Phe Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Gly Ala Pro Glu Glu Ser Arg Leu Arg Asp Ser Val Val Leu Thr Phe 
            180                 185                 190         


Gly Asp His Ala Gly Val Ser Lys Ala Arg Ala Ser Asp Gly Trp Ser 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ser Gln Val Ala Ala Ala Ser Ala Gly Glu 
    210                 215                 220                 


Ala Thr Glu Leu Val Leu Arg Arg Asn Asp Leu Thr Ile Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Leu 
                245                 250                 255     


Val Arg Arg Ile Gly Val Ala Pro Glu Arg Val Ile Thr Asn Ile Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  42
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamD polypeptide

<400>  42

Val Ser Gly Gly Ile Trp Val Gly Arg Gly Met Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Val Pro Ala Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Glu Asp Thr Glu Ser Val Pro Tyr Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Lys Asn Ala Gly Val Asp Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Met Val Val Phe Ser Ser Phe Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Gly Phe Asp Val Cys Ala Ala Cys Val Gly Phe Met His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Leu Leu Thr Thr His Arg Trp Arg His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Trp Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Gly Ala Pro Glu Asp Ser Arg Leu Arg Asp Ser Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Ala Val Ser Arg Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Thr Ile Ser Gln Val Ala Ala Ala Thr Ala Ala Glu 
    210                 215                 220                 


Ala Thr Asp Leu Val Leu Arg Lys Asn Asp Met Thr Ile Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Lys Ile Ser Glu Glu Leu 
                245                 250                 255     


Leu Arg Arg Ile Gly Val Ala Pro Glu Arg Val Leu Ser Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  43
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamD polypeptide

<400>  43

Val Ser Gly Gly Ile Trp Leu Gly Arg Gly Leu Thr Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Asp Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Ile Ser Asp Asp Thr Glu Thr Val Pro Tyr Met Ala 
    50                  55                  60                  


Ile Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Arg Ile Ala Met Lys Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Gly Phe Asp Val Cys Ala Ala Cys Val Gly Phe Leu His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Leu Leu Thr Ser His Arg Trp Arg His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Phe Ser Lys Arg Ile Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Ala Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Ala Ala Pro Asp Asp Ser Arg Leu Arg Asp Ser Leu Leu Leu Ser Tyr 
            180                 185                 190         


Gly Asp His Gly Gly Val Ser Lys Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Thr Ile Ser Gln Val Ala Ala Gly Thr Ala Gly Asp 
    210                 215                 220                 


Ala Thr Glu Leu Val Leu Arg Arg Asn Asp Leu Ser Leu Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Arg Leu Ser Glu Glu Ile 
                245                 250                 255     


Met Arg Arg Ile Gly Val Ala Pro Glu Lys Leu Leu Thr Asn Met Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Ile Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Tyr Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  44
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamD polypeptide

<400>  44

Val Ser Gly Gly Ile Trp Met Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly His Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Glu Leu Pro 
            20                  25                  30          


Asp Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Ile Ser Glu Glu Thr Glu Thr Val Pro Tyr Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Lys Asn Ala Gly Leu Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Phe Ala 
                85                  90                  95      


Pro Glu Asp Gly Pro Lys Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Ile His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Met Leu Thr Ser His Lys Phe Lys His Ala Leu 
    130                 135                 140                 


Val Ile Cys Ser Asp Gln Phe Ser Arg Arg Met Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Trp Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Val 
                165                 170                 175     


Ala Ala Pro Asp Asp Ser Arg Leu Arg Asp Ser Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Gly Val Thr Lys Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Thr Ile Ser Asn Leu Gly Gly Ala Thr Ala Ala Asp 
    210                 215                 220                 


Ala Thr Asp Leu Leu Leu Arg Arg Asn Asp Val Thr Val Ala Asp Val 
225                 230                 235                 240 


Asp Arg Val Val Pro His Pro Gly Ser Ala Arg Ile Ser Asp Glu Leu 
                245                 250                 255     


Val Arg Lys Ile Gly Val Ala Pro Asp Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Ile Arg Lys Gly Asn Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Tyr Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  45
<211>  1035
<212>  DNA
<213>  Streptomyces alboniger

<400>  45
atgcccgaaa cccggtcacc gctcgacggc ggaggcccgc cggtcgtgct cagtggtgtc       60

ggccactact tccccggcga gccggtcacc aacgaccact tcgcccgcct gcccgagctg      120

gacgtggacg acgcctggat acgcgcgtac acgggcgtgc ggacccgtca ctgggccggc      180

cccgaggaac ggttcgccga gatgggcgtc aaggcggccc ggcgcgctct cgacgacgcg      240

ggcctcgaca tctccgacgt ggacgtgatc gtcggcacca gcgcgaccgc ccggccacgt      300

gccaacccct cctccctcgg caacaactac atggacatct ccctgccggt gcagcggcag      360

ctgggcgccc gtgacgcgtt ctgcttcgac gtgaccgcgg tcgcctgcgc aggattcctg      420

tacgcgagcg tggtggcccg cgggctgctg gcgacgacgg gggcccggac cgccctcgtc      480

gtgtgcgcgg aaagcccgca cgccatcctc aacttcgggt tcaagaactc cgcgctcttc      540

ggcgcgggcg cggcggccgc ggtgtggcgg cgcggcgagt cctcgggcgg cggcgccgac      600

ggcctgccga cgcgcagcgg catgatcgac gtcgtcctgc gcgccgacgg ccgctactac      660

gacgccttcg acatcgacga gaacgacaag atggtgatgc gcggcggggt gctctccgag      720

gtcacgcccg acatgctcgt cgacgccgga gagacggtcc tcaagcgcaa cggcctggca      780

ccggaacaga tttcctggtg cattccgcat caggcgaaca ccaacctcct gtatccgatg      840

gcggaccgcc tcggaattcc gcgcgagcgg atgctcctga atcttccgcg ccgcggcaac      900

acatcgagtg tgggaatgcc gagcgcgctc tccgaatacg tcggtgacgg cacggtgaaa      960

cccggcgaac tactcctggg cgtaagcatc gggcgcggcc tgagctgggg cgccatggtt     1020

ttccggtacc agtga                                                      1035


<210>  46
<211>  344
<212>  PRT
<213>  Streptomyces alboniger

<400>  46

Met Pro Glu Thr Arg Ser Pro Leu Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Glu Leu Asp Val Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Ala Tyr Thr Gly Val Arg Thr Arg His Trp Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Arg Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Leu Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro His Ala Ile Leu Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Ser Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Met 
        195                 200                 205             


Ile Asp Val Val Leu Arg Ala Asp Gly Arg Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Met Val Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Asp Ala Gly Glu Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Ala Pro Glu Gln Ile Ser Trp Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu Tyr Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Leu Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Val Gly Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  47
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamE polypeptide

<400>  47

Met Pro Glu Thr Arg Ser Pro Leu Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Glu Leu Asp Leu Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Ala Tyr Ser Gly Val Arg Thr Arg His Trp Ala Ala Pro Asp Glu Arg 
    50                  55                  60                  


Phe Gly Glu Met Gly Val Lys Ala Ala Arg Lys Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Ile Asp Ile Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Gly Asn Pro Ser Ser Leu Gly Asn Asn Trp Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Met 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Thr Thr Ala Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro His Ala Ile Ile Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Ser Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Met 
        195                 200                 205             


Ile Asp Val Val Leu Arg Ala Asp Gly Arg Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Val Asp Glu Asn Asp Lys Met Val Met Lys Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Val Val Asp Ala Gly Glu Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Ala Pro Glu Gln Ile Ser Trp Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu Tyr Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Met Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Val Gly Asp Gly Thr Leu Arg 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  48
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamE polypeptide

<400>  48

Met Pro Glu Thr Arg Ser Pro Leu Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Glu Val Asp Val Asp Asp Ala Trp Ile Lys 
        35                  40                  45              


Ala Tyr Thr Gly Val Arg Ser Arg His Trp Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Arg Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Val Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Gly Val Ala Cys Ala Gly Phe Val Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro His Ala Ile Leu Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Ser Ala Gly Gly Ala Asp Gly Leu Pro Ser Arg Thr Gly Met 
        195                 200                 205             


Val Asp Val Val Leu Arg Ala Asp Gly Arg Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Ile Val Leu Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Leu Val Val Asp Ala Gly Glu Thr Val Leu Lys Lys 
                245                 250                 255     


Asn Gly Ile Ala Pro Glu Gln Ile Ser Trp Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Ile Leu Tyr Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Leu Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Ile Gly Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  49
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamE polypeptide

<400>  49

Met Pro Glu Thr Arg Ser Pro Leu Asp Gly Gly Gly Pro Pro Val Leu 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Glu Leu Asp Val Asp Asp Gly Trp Ile Arg 
        35                  40                  45              


Ala Tyr Thr Gly Val Lys Thr Arg His Trp Ala Ala Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Asp Met Gly Leu Lys Ala Ala Arg Arg Ala Leu Asp Glu Ala 
65                  70                  75                  80  


Gly Ile Glu Ile Ser Asp Val Asp Leu Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro His Ala Leu Leu Asn Trp Ala Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Ser Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Met 
        195                 200                 205             


Ile Asp Val Val Val Arg Ala Asp Gly Arg Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Met Leu Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Leu Leu Val Glu Ala Gly Glu Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Ala Pro Glu Gln Ile Ser Phe Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu Tyr Pro Val Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Ile Leu Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Ile Gly Asp Gly Thr Leu Arg 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Leu Val Phe Arg Tyr Gln 
            340                 


<210>  50
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamE polypeptide

<400>  50

Met Pro Glu Thr Arg Ser Pro Met Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Glu 
            20                  25                  30          


His Phe Ala Arg Val Pro Glu Ile Asp Val Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Ala Tyr Thr Gly Val Arg Ser Arg His Trp Ala Gly Pro Asp Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Arg Ala Ala Arg Lys Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Val Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Leu Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Ser Thr Gly Gly Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro His Ala Val Leu Asn Tyr Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Lys Gly 
            180                 185                 190         


Glu Ser Ser Gly Gly Gly Ala Asp Gly Leu Pro Ser Lys Ser Gly Met 
        195                 200                 205             


Leu Asp Val Val Leu Arg Ala Asp Gly Arg Tyr Tyr Asp Ala Phe Glu 
    210                 215                 220                 


Leu Asp Glu Gln Glu Lys Leu Val Val Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Asp Ala Gly Asp Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Ile Ala Pro Asp Gln Ile Ser Tyr Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu Tyr Pro Met Gly Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Ile Leu Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Leu Gly Glu Gly Thr Ile Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Leu Ser Ile Gly Arg Gly Met Thr Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  51
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamE polypeptide

<400>  51

Met Pro Glu Thr Arg Ser Pro Leu Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Ile Gly His Tyr Phe Pro Gly Glu Pro Val Ser Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Glu Val Asp Ile Asp Asp Gly Trp Ile Arg 
        35                  40                  45              


Gly Tyr Thr Gly Val Arg Thr Arg His Phe Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Arg Ala Leu Glu Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Met Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Gly Arg Pro Arg Ala Asn Pro Ser Ser Leu Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Leu Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Glu Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Leu Ala Arg Gly Leu Leu Ala Ser Thr Gly Gly Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Thr Pro His Ala Val Ile Asn Phe Gly Phe Arg Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Ser Ala Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Met 
        195                 200                 205             


Leu Asp Val Val Leu Arg Gly Asp Gly Arg Phe Trp Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Gln Asp Lys Met Met Val Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Asp Ala Gly Glu Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Ala Pro Glu Gln Ile Ser Trp Cys Ile Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu Tyr Pro Met Ala Asp Arg Leu Gly Ile Pro Lys 
        275                 280                 285             


Glu Arg Met Leu Ile Asn Leu Pro Arg Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Gly Leu Ser Asp Tyr Val Ala Asp Gly Thr Leu Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Val Ser Trp 
                325                 330                 335     


Gly Ala Ile Val Phe Arg Tyr Gln 
            340                 


<210>  52
<211>  795
<212>  DNA
<213>  Streptomyces alboniger

<400>  52
atgtccgatt ccaggaatgc gctggtgacc gggggaaccc gcggcctcgg cctggccgtc       60

gcccggctgc tggtggcgcg gggatggcgc accacggtcc tcggcctcga cccgggacgc      120

ctggagaagg tgcgggccat ggccgaggcc gagggcctgg acctgcgcgc ggtgcgggcc      180

gatgtcacct cggaggagtc ggtgcgggag gtgttcgccg acctgacccg gagcgagccg      240

ctgcacctgt gcgtgaacaa cgcgggccgc aacctctccc gtctgctact gcgcgaaccg      300

cgggagggca gcggcgccga gctgctcacg catccgctcg acgactggga gcagacgctg      360

cggctgtgcc tgacgggggt cttcctcgtc ggccgcgagg ccgccgccgg catggtgcgg      420

cacggggtgc ccggcgccat cgtcaacgtc tcctccggtc tcgcggcggg cgcctacggg      480

cagtccgcgt acaccgccgc gaaggcgggc gtggaggcgc tgacccgtac ctggtcctat      540

gaactcggcc cctacgggat cagggtggcg gcggtcgcgc cgggcgtgat ggacggtgag      600

gcactgcgcg agaagagcac ggcctttcca cggcacgccc gttatatgga cgggctgaag      660

cgttttgtcc cgctgggccg ttgggggacg gaggaagaga tagcggacgc ggtgtgcttc      720

gccgcggaaa acccctatat caccggatcg gtcattcggg tcgacggcgg cgggccgccc      780

ggctgggttc cgtaa                                                       795


<210>  53
<211>  264
<212>  PRT
<213>  Streptomyces alboniger

<400>  53

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Arg Leu Leu Val Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Glu Ala Glu Gly Leu Asp Leu Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Arg Glu Val Phe Ala Asp Leu Thr Arg Ser Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Arg Glu Gly Ser Gly Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Val Arg His Gly Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Gly Thr Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  54
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamO polypeptide

<400>  54

Met Thr Glu Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Arg Leu Leu Val Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Leu Glu Lys Val Arg Ala Leu Ala 
        35                  40                  45              


Glu Ala Glu Gly Leu Asp Leu Arg Ala Ile Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Lys Glu Val Phe Ala Asp Leu Thr Arg Ser Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Lys Glu Gly Ser Gly Ala Glu Leu Val Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Ile Arg His Ala Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Ile Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Gly Arg Tyr Met Glu Gly Leu Lys Arg Phe Ile Pro 
    210                 215                 220                 


Leu Gly Arg Trp Gly Thr Glu Asp Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  55
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamO polypeptide

<400>  55

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Arg Leu Leu Val Ala Lys Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Glu Ala Glu Gly Leu Asp Leu Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Lys Glu Val Phe Ala Glu Leu Thr Arg Thr Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Arg Glu Gly Ser Ala Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Val Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Val Arg His Gly Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Gly Leu Thr Lys 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Ala Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Ile Met Asp Gly Glu Ala Val Arg Glu Arg Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Val Gly Arg Trp Ala Thr Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  56
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamO polypeptide

<400>  56

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Lys Leu Leu Val Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Ala Arg Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Glu Ala Glu Gly Leu Glu Leu Arg Ala Val Arg Gly Asp Val Thr Ser 
    50                  55                  60                  


Glu Asp Ser Val Arg Glu Val Phe Ala Asp Leu Thr Arg Thr Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Thr Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Arg Asp Gly Ser Ala Gly Glu Leu Leu Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Ile Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Val Lys His Gly Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Val Ala Ala Gly Gly Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Ser Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Asp Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Ala Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Gly Thr Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Thr Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Met Pro 
            260                 


<210>  57
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamO polypeptide

<400>  57

Met Thr Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Arg Leu Leu Val Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Val Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Glu Ala Glu Gly Val Asp Ile Lys Ala Ile Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Asp Glu Ser Val Lys Glu Val Phe Ala Asp Leu Thr Arg Ser Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Thr Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Lys Glu Gly Thr Gly Gly Glu Leu Met Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Val Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Val Lys His Gly Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Asn Ser Ala Tyr Ser Ala Ala Lys Ala Gly Val Glu Gly Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Ala Pro Phe Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Gly Pro Gly Met Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Ser Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Lys Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Gly Thr Glu Asp Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Val Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Tyr Val Pro 
            260                 


<210>  58
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamO polypeptide

<400>  58

Met Thr Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Ala Lys Val Leu Val Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Val Gly Leu Asp Pro Gly Arg Leu Asp Lys Val Arg Ala Ile Ala 
        35                  40                  45              


Glu Ala Asp Gly Leu Asp Leu Arg Ala Leu Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Asp Ser Val Arg Glu Val Phe Ala Asp Leu Thr Arg Ser Glu Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Leu Arg Glu Pro Lys Glu Ala Ser Gly Ala Glu Leu Leu Ser His Pro 
            100                 105                 110         


Leu Asp Asp Phe Glu Gln Thr Leu Lys Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Gly Met Val Arg His Gly Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Ser Ala Ala Lys Ala Gly Val Asp Gly Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Glu Gly Glu Ala Leu Lys Glu Lys Ser Thr Gly 
        195                 200                 205             


Phe Pro Lys His Gly Arg Tyr Val Asp Gly Leu Arg Lys Phe Val Pro 
    210                 215                 220                 


Ile Gly Arg Trp Gly Thr Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Leu Pro 
            260                 


<210>  59
<211>  1080
<212>  DNA
<213>  Streptomyces alboniger

<400>  59
gtgaactacg gctttttcgc ggggtacttc gagtacccgc ggcatgaatc atcgagtact       60

ggaggccaga tgcagccgaa tgccgacgcc actagttttt cgtccatgac cacaggcctg      120

cacggaatct gggaagacgc cggaatacgt ttcaccggat tcggccacta tttcggctcc      180

gaggaaatac acaaccacgg cgtcgagaac gcgacgacga gccacgtgga ggaccgcgtc      240

atcggcgggg tcggtgtccg cacccgctac cgggccaacg acgacgagac ccccgtgttc      300

atggccgcgc aggcctcccg gcaggcgctg gagcaggccg gggtcgacgc cgacgacatc      360

gatgtgatgg tcgtcagcca ttggacggac cgcaactacg tgcacgaggt gggcgcgctc      420

accgcggcgg agctgggaat gaagggctcc atggccttcg aggtgtgcgg ctcctgcgcc      480

ggtttcatcc aggcggtgca caccgcggcg tcgttcctga ccgccccgac cggctaccgc      540

aaggcgctgg tggccaccac cgagcgggtc acgcggcggg tgcggcccgg ctccaagggc      600

tcaatgctcg tctcggacgg cgccggcgcg tgtgtcctcg aagccacccc cggcggctcc      660

cccgggctca tcgactccgt gttccacacc gacggcagcc tcgcccacat gtccgcggcg      720

agcggggaca agggatgggt gaagagccac ccggacctca acgacgtcgc cctggcccac      780

atcagcgaca ccgtggagga gatcctcggc cgcaacaaac tggcgatcgg cgacatcgac      840

tggctcatcc cccactcggg gaccgagccg ctggccaagg gcatccagca caacctggga      900

gcggacccgg cgcgcgtcct gaccaacctc gccttccgcg gcaacgtctc cagcgcctcc      960

atccccacca ccgtctcgga actgcgggag cgcggcgtcg tcaaacccgg cgacctggtg     1020

ctctccccct ccatcggcgg cggcgtctgg tgctggggca gcctcctgta ccggatctga     1080


<210>  60
<211>  359
<212>  PRT
<213>  Streptomyces alboniger

<400>  60

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Thr Thr Gly Leu His Gly Ile Trp Glu Asp Ala Gly 
        35                  40                  45              


Ile Arg Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Asn Ala Thr Thr Ser His Val Glu Asp Arg Val 
65                  70                  75                  80  


Ile Gly Gly Val Gly Val Arg Thr Arg Tyr Arg Ala Asn Asp Asp Glu 
                85                  90                  95      


Thr Pro Val Phe Met Ala Ala Gln Ala Ser Arg Gln Ala Leu Glu Gln 
            100                 105                 110         


Ala Gly Val Asp Ala Asp Asp Ile Asp Val Met Val Val Ser His Trp 
        115                 120                 125             


Thr Asp Arg Asn Tyr Val His Glu Val Gly Ala Leu Thr Ala Ala Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Ile Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg 
            180                 185                 190         


Arg Val Arg Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile 
    210                 215                 220                 


Asp Ser Val Phe His Thr Asp Gly Ser Leu Ala His Met Ser Ala Ala 
225                 230                 235                 240 


Ser Gly Asp Lys Gly Trp Val Lys Ser His Pro Asp Leu Asn Asp Val 
                245                 250                 255     


Ala Leu Ala His Ile Ser Asp Thr Val Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Leu Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala 
    290                 295                 300                 


Arg Val Leu Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Thr Thr Val Ser Glu Leu Arg Glu Arg Gly Val Val Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp 
            340                 345                 350         


Gly Ser Leu Leu Tyr Arg Ile 
        355                 


<210>  61
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamK polypeptide

<400>  61

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Thr Thr Gly Leu His Gly Ile Trp Glu Asp Ala Gly 
        35                  40                  45              


Leu Arg Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Asn Ala Thr Thr Ser His Val Glu Asp Arg Val 
65                  70                  75                  80  


Ile Ala Ala Val Gly Val Arg Thr Arg Tyr Arg Ala Asn Asp Asp Glu 
                85                  90                  95      


Thr Pro Val Phe Met Ala Ala Gln Ala Ser Lys Gln Ala Leu Glu Asn 
            100                 105                 110         


Ala Gly Val Asp Ala Asp Asp Ile Asp Leu Met Val Val Ser His Trp 
        115                 120                 125             


Thr Asp Arg Asn Tyr Val His Glu Val Gly Ala Ile Thr Ala Ala Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Ile Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg 
            180                 185                 190         


Arg Val Arg Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile 
    210                 215                 220                 


Asp Ser Met Phe His Ser Asp Gly Ser Leu Gly His Met Ser Ala Ala 
225                 230                 235                 240 


Thr Gly Asp Lys Gly Trp Leu Lys Thr His Pro Glu Leu Asn Asp Val 
                245                 250                 255     


Ala Val Ala His Ile Ser Asp Ser Val Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Leu Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala 
    290                 295                 300                 


Arg Val Leu Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Ser Thr Val Ser Glu Leu Arg Glu Arg Gly Val Leu Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp 
            340                 345                 350         


Gly Ser Leu Leu Tyr Arg Ile 
        355                 


<210>  62
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamK polypeptide

<400>  62

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Thr Thr Gly Leu His Gly Ile Trp Glu Asp Gly Gly 
        35                  40                  45              


Val Arg Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Asn Ala Thr Thr Ser His Val Asp Asp Arg Val 
65                  70                  75                  80  


Ile Gly Gly Val Gly Val Arg Thr Arg Tyr Arg Ala Asn Asp Glu Glu 
                85                  90                  95      


Thr Pro Val Phe Met Ala Gly Gln Ala Ser Arg Gln Ala Leu Glu Gln 
            100                 105                 110         


Ala Gly Val Asp Ala Glu Asp Ile Asp Val Met Val Val Ser His Trp 
        115                 120                 125             


Ser Asp Arg Asn Tyr Val His Glu Val Gly Ala Leu Thr Ala Gly Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Ile Gln Ala Val His Thr Ala Ala Ser Tyr Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Lys Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg 
            180                 185                 190         


Arg Val Arg Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Thr Pro Ala Gly Ser Pro Gly Leu Ile 
    210                 215                 220                 


Glu Ser Val Phe His Thr Asp Gly Ser Leu Ala His Met Ser Ala Ala 
225                 230                 235                 240 


Ser Gly Asp Lys Gly Trp Val Lys Ser His Pro Asp Leu Asn Asp Val 
                245                 250                 255     


Ala Leu Ala His Ile Ser Asp Thr Ile Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Tyr Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Leu Ala Lys Ala Val Gln His Asn Leu Gly Ala Asp Pro Ala 
    290                 295                 300                 


Arg Val Leu Thr Asn Val Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Thr Thr Val Ser Glu Leu Arg Glu Arg Gly Val Val Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Phe 
            340                 345                 350         


Gly Ser Leu Leu Tyr Arg Ile 
        355                 


<210>  63
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamK polypeptide

<400>  63

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Thr Thr Gly Leu His Gly Ile Trp Glu Asp Ala Gly 
        35                  40                  45              


Ile Lys Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Asn Ala Thr Thr Ser His Val Glu Asp Arg Val 
65                  70                  75                  80  


Ile Ala Gly Val Gly Val Lys Thr Arg Tyr Arg Ala Asn Asp Asp Glu 
                85                  90                  95      


Thr Pro Ile Phe Met Ala Ala Gln Ala Ser Lys Gln Ala Leu Glu Gln 
            100                 105                 110         


Ala Gly Leu Asp Ala Asp Asp Ile Asp Leu Met Val Leu Ser His Trp 
        115                 120                 125             


Thr Asp Arg Gln Tyr Val His Glu Val Gly Ala Ile Thr Ala Ala Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Phe Glu Val Cys Ala Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Leu Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Arg Arg Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg 
            180                 185                 190         


Arg Val Arg Pro Gly Ser Lys Gly Ser Val Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile 
    210                 215                 220                 


Asp Thr Val Phe His Ser Asp Gly Thr Leu Ala His Leu Ser Gly Ala 
225                 230                 235                 240 


Ser Gly Asp Lys Gly Trp Val Arg Ser His Pro Asp Leu Asn Asp Leu 
                245                 250                 255     


Ala Val Ala His Ile Ser Asp Thr Val Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Met Ala Lys Ala Leu Gln His Asn Leu Gly Ala Asp Pro Ala 
    290                 295                 300                 


Arg Val Leu Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Thr Thr Val Ser Glu Leu Arg Glu Arg Gly Val Val Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp 
            340                 345                 350         


Gly Ser Ile Leu Tyr Arg Ile 
        355                 


<210>  64
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamK polypeptide

<400>  64

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Thr Thr Gly Leu His Gly Ile Phe Glu Asp Ala Gly 
        35                  40                  45              


Val Lys Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Asn Ala Thr Thr Ser His Val Glu Asp Arg Val 
65                  70                  75                  80  


Ile Ala Gly Val Gly Val Lys Thr Arg Tyr Arg Ala Asn Asp Asp Asp 
                85                  90                  95      


Ser Pro Val Phe Met Ala Ala Gln Ala Ser Arg Gln Ala Leu Asp Gln 
            100                 105                 110         


Ala Gly Ile Asp Ala Glu Asp Ile Asp Leu Met Val Val Ser His Trp 
        115                 120                 125             


Thr Asp Arg Asn Tyr Leu His Glu Val Gly Ala Ile Thr Ala Ala Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Tyr Glu Val Cys Gly Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Ile Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg 
            180                 185                 190         


Arg Ile Arg Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Ser Pro Gly Gly Thr Pro Gly Leu Ile 
    210                 215                 220                 


Asp Thr Val Phe His Thr Glu Gly Ser Leu Ala His Leu Ser Ala Ala 
225                 230                 235                 240 


Ser Ala Asp Lys Gly Tyr Met Arg Ser His Pro Glu Leu Asn Asp Leu 
                245                 250                 255     


Ala Leu Ala His Val Ser Asp Thr Ile Glu Glu Ile Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Val Ala Lys Ala Ile Gln His Asn Leu Gly Ala Asp Pro Gly 
    290                 295                 300                 


Arg Leu Val Ser Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Thr Thr Val Ser Asp Leu Arg Glu Arg Gly Leu Val Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp 
            340                 345                 350         


Gly Ser Leu Leu Tyr Arg Ile 
        355                 


<210>  65
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamK polypeptide

<400>  65

Val Asn Tyr Gly Phe Phe Ala Gly Tyr Phe Glu Tyr Pro Arg His Glu 
1               5                   10                  15      


Ser Ser Ser Thr Gly Gly Gln Met Gln Pro Asn Ala Asp Ala Thr Ser 
            20                  25                  30          


Phe Ser Ser Met Ser Thr Gly Leu His Gly Leu Trp Glu Asp Ala Gly 
        35                  40                  45              


Ile Arg Phe Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His 
    50                  55                  60                  


Asn His Gly Val Glu Gln Ala Thr Thr Ser His Val Glu Glu Arg Val 
65                  70                  75                  80  


Ile Ala Gly Val Gly Val Arg Thr Arg Tyr Arg Ala Asn Asp Glu Glu 
                85                  90                  95      


Thr Pro Val Phe Met Ala Ala Gln Ala Ser Arg Asn Ala Leu Glu Gln 
            100                 105                 110         


Ala Gly Leu Asp Ala Asp Glu Ile Asp Val Met Val Val Ser His Trp 
        115                 120                 125             


Thr Asp Arg Asn Tyr Leu His Glu Val Gly Ala Leu Thr Ala Gly Glu 
    130                 135                 140                 


Leu Gly Met Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala 
145                 150                 155                 160 


Gly Phe Ile Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ala Pro 
                165                 170                 175     


Thr Gly Tyr Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Met Thr Arg 
            180                 185                 190         


Arg Ile Arg Pro Gly Ser Lys Gly Ser Leu Leu Val Ser Asp Gly Ala 
        195                 200                 205             


Gly Ala Cys Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Ala Leu Val 
    210                 215                 220                 


Glu Ser Val Trp His Ser Glu Gly Ser Met Gly His Met Ser Ala Ala 
225                 230                 235                 240 


Ser Gly Asp Lys Gly Trp Val Lys Ser His Pro Glu Leu Asn Asp Met 
                245                 250                 255     


Ala Val Ala His Leu Ser Glu Thr Ile Glu Glu Leu Leu Gly Arg Asn 
            260                 265                 270         


Lys Leu Ala Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr 
        275                 280                 285             


Glu Pro Leu Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala 
    290                 295                 300                 


Lys Ile Leu Thr Asn Ile Ala Phe Arg Gly Asn Val Ser Ser Ala Ser 
305                 310                 315                 320 


Ile Pro Thr Thr Val Ser Glu Leu Arg Asp Arg Gly Val Leu Lys Pro 
                325                 330                 335     


Gly Asp Leu Val Leu Ser Pro Ser Ile Gly Ala Gly Val Trp Cys Trp 
            340                 345                 350         


Gly Ser Val Leu Tyr Arg Ile 
        355                 


<210>  66
<211>  1296
<212>  DNA
<213>  Streptomyces alboniger

<400>  66
gtgaccacga ccaagggccc ccgggacgca ctcgtcaccg gcatgggctt ctgtctgccg       60

gggcgtacgg cgccgacggc gacacccgag cagttctgga cggccgtcgc gcacggcgac      120

tccttcctcg cgcaggacga cggcacctac ttcggcagcg tccccctaga cccggactcc      180

gtcgccgctc gactgccgga gatcccgccg cgcttcgtcg agaagtactc cgacatccat      240

ctgtacgggc tgctcgccct cctggaggcg tgcgaggacg ccgcgctcga ctggcgttcg      300

ggcgcactgg gcgaggccgc cgtactcgcg ggccgcaacg ccacggccga cgccatcgtc      360

gacacgtatc tgccggtgct cctcgccgac acccggaaca tcagcccgcg cgaggcccgc      420

tcgatactgt tccgcaacgt tctcaacgcg gtgatgtcgg acgtcgagac gacccaggcg      480

ggcctcgtcg gcgccaccgg ccccagctac acgctgtcct gcgggtgcgc ctcctcgtcc      540

gtgctgctcg gcaacgcggc ccgcatgatc gcagcgggcg agacggacat cgcggtggtc      600

accggcgccg actactggcg cgagagcaga ctgcggcagt acgcggacct cgaggcacgc      660

tcggtgaccg ggagcgaacc gcagaccgcc accctcgtcg acgagcccat gcgcccctac      720

gaccagcggg ccgccggcct caactacggc aacggcgcgg ccaccttgat cctggagagc      780

cgcgagcacg cgcggcgcag gggcgccagg acctacggac ggctcctggg ccagaccacc      840

acccgcaacg cccagcccaa cctcgccctc gacgtcgagg gcacgggggc ggtgcgcgcc      900

gcgcgctcct gcatggccgg gatcgcatcg ccggacgaga tcgactacgt caacggcgcc      960

gcgaccggcg accgggcgtt caacctcatg gaaggcaaca tcatgcccgc catcttcggt     1020

gagcgggcgg cccggctgcc cgtcaccgtc caggaggccg tgttcggaca cagcggggcc     1080

ccgctcggag tgatcggtgt ggcggcgacg ctccagatga tgggccacgg ccacatcgcc     1140

ccgaccgcga actgcgagaa gcccgccgac gtgtgcacct tcgacccggt gcccggcacc     1200

caggggcggc ccgcgcgcat cgacctggcc ctcagtctca actacacgat cggctccgtg     1260

gccagcgcca ttctcctggg aggcaccgat gactga                               1296


<210>  67
<211>  431
<212>  PRT
<213>  Streptomyces alboniger

<400>  67

Val Thr Thr Thr Lys Gly Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Thr Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Asp Ser Phe Leu Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Val Pro Leu Asp Pro Asp Ser Val Ala Ala Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Glu Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Ser Gly Ala Leu Gly Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Ala Ile Val Asp Thr Tyr Leu Pro Val Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg Asn Ile Ser Pro Arg Glu Ala Arg Ser Ile Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Val Leu Leu Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Asp Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Ser Glu Pro Gln Thr Ala Thr Leu Val Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Gln Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Val Glu Gly Thr Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Glu Arg Ala Ala Arg Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Gln Gly Arg Pro Ala Arg Ile Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Gly Gly Thr Asp Asp 
            420                 425                 430     


<210>  68
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamJ polypeptide

<400>  68

Val Thr Thr Thr Lys Gly Pro Arg Asp Ala Leu Val Thr Gly Leu Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Thr Ala Pro Thr Gly Thr Pro Asp Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Asp Ser Phe Leu Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Ala Ser Val Pro Leu Asp Pro Asp Ser Val Ala Ala Arg 
    50                  55                  60                  


Leu Pro Glu Val Pro Pro Arg Phe Val Glu Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Ser Gly Ala Leu Gly Asp Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Gly Met Leu Asp Thr Tyr Leu Pro Val Leu Leu 
        115                 120                 125             


Ala Asp Ser Arg Asn Ile Ser Pro Arg Glu Ala Arg Ser Ile Met Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Ile Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Ile Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Val Leu Leu Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Asp Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Ser Glu Pro Gln Thr Ala Thr Leu Val Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Gln Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Ile Gly Gln Thr Ser Ser Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Val Glu Gly Thr Gly Ala Met Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Glu Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Gln Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Asp Arg Ala Ala Arg Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Asp Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Gln Gly Arg Pro Ala Lys Ile Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Gly Gly Thr Asp Asp 
            420                 425                 430     


<210>  69
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamJ polypeptide

<400>  69

Val Thr Ser Ser Lys Ala Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Thr Gly Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Asp Ser Phe Leu Gly Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Trp Gly Ser Val Pro Leu Asp Pro Asp Ser Ile Ala Ala Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Glu Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Thr Gly Ala Leu Gly Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Ala Ile Leu Asp Thr Tyr Leu Pro Met Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg Asn Ile Ser Pro Arg Glu Ala Arg Ser Val Leu Tyr 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Phe Ser Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Val Leu Leu Gly Asn Ala Ala Arg Leu Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Met Ala Val Val Thr Gly Ala Asp Tyr Phe Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Asp Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Ser Glu Pro Gln Thr Ala Thr Leu Val Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Gln Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Val Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Val Glu Gly Thr Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Glu Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Ile Glu Gly Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Glu Lys Ala Ala Lys Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Gln Gly Arg Pro Ala Arg Ile Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Gly Gly Thr Asp Asp 
            420                 425                 430     


<210>  70
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamJ polypeptide

<400>  70

Val Thr Thr Thr Lys Ala Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Ala Arg Ser Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Asp Ser Phe Ile Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Val Pro Leu Asp Pro Asp Ser Val Gly Ala Arg 
    50                  55                  60                  


Leu Pro Asp Val Pro Pro Arg Phe Val Glu Arg Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Ile 
                85                  90                  95      


Asp Trp Arg Ser Gly Ala Met Gly Glu Ala Ala Val Val Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Ala Ile Val Asp Thr Tyr Leu Pro Ile Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg Asn Leu Ser Pro Arg Glu Ala Arg Ser Ile Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Phe Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Ile Leu Leu Gly Gln Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Asp Leu Glu Gly Arg Ser Val Thr Gly 
    210                 215                 220                 


Ser Glu Pro Gln Ser Ala Thr Met Val Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Asn Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Lys Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Ile 
        275                 280                 285             


Ala Leu Asp Val Glu Gly Thr Gly Ala Val Arg Ala Ala Arg Thr Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Asp Asp Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Ile Glu Ala Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Asp Lys Ala Ala Lys Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Glu Pro Val Pro Ala Thr 
385                 390                 395                 400 


Gln Gly Arg Pro Ala Arg Ile Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Gly Gly Thr Asp Asp 
            420                 425                 430     


<210>  71
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamJ polypeptide

<400>  71

Val Thr Thr Thr Lys Gly Pro Lys Asp Ala Leu Val Thr Gly Leu Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Ser Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Ser Gly Val Ala His Gly Glu Ser Phe Met Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Val Pro Leu Asp Pro Asp Ser Val Ala Ala Arg 
    50                  55                  60                  


Leu Pro Glu Val Pro Pro Arg Phe Val Glu Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Val Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Lys Ser Gly Ala Leu Gly Asp Ala Ala Val Val Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Glu Ala Leu Leu Asp Thr Tyr Leu Pro Val Leu Leu 
        115                 120                 125             


Ala Glu Ser Arg Gln Val Ser Pro Arg Glu Ala Arg Ser Ile Met Phe 
    130                 135                 140                 


Arg Asn Val Met Asn Ala Leu Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Met Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Val Leu Leu Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Asp Thr Asp Leu Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Thr Arg Leu Arg Gln Tyr Ala Asp Leu Glu Ala Arg Ser Leu Ser Gly 
    210                 215                 220                 


Ser Glu Pro Gln Thr Ala Thr Ile Val Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Gln Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Lys Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Val Gly Gln Thr Ser Ser Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Val Asp Gly Thr Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Glu Asp Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Asp Arg Ala Ala Arg Ile Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Ser 
385                 390                 395                 400 


Gln Gly Arg Pro Ala Lys Val Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Ala Ala Thr Glu Asp 
            420                 425                 430     


<210>  72
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamJ polypeptide

<400>  72

Val Thr Thr Thr Lys Ala Pro Lys Asp Ala Leu Val Thr Gly Leu Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Thr Ala Pro Thr Ala Thr Pro Asp Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Asp Ser Phe Ile Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Ala Ser Val Pro Leu Asp Pro Asp Ser Ile Gly Ala Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Lys Phe Val Asp Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Glu Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Thr Gly Ala Leu Gly Glu Ala Ala Val Ile Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Glu Ala Ile Leu Asp Thr Tyr Leu Pro Ile Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg Gln Val Thr Pro Arg Glu Ala Arg Ser Val Met Phe 
    130                 135                 140                 


Arg Asn Leu Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ser Val Leu Leu Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Met Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Met Arg Gln Tyr Ala Asp Met Glu Ala Arg Ser Val Ser Gly 
    210                 215                 220                 


Ser Asp Pro Gln Thr Ala Ser Leu Val Asp Glu Pro Ile Arg Pro Tyr 
225                 230                 235                 240 


Asp Gln Arg Ala Ala Gly Val Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Arg Leu Leu Gly Gln Thr Thr Ser Arg Asn Ala Gln Pro Asn Val 
        275                 280                 285             


Ala Leu Asp Leu Glu Gly Thr Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Ile Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Ile Glu Ala Asn Ile Met Pro 
                325                 330                 335     


Ala Leu Phe Gly Glu Arg Ala Ala Lys Ile Pro Val Thr Val Gln Glu 
            340                 345                 350         


Gly Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Val Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Gly His Gly His Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Leu Cys Thr Phe Asp Pro Val Pro Gly Ser 
385                 390                 395                 400 


Gln Ala Arg Pro Ala Arg Val Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Leu Gly Gly Thr Asp Asp 
            420                 425                 430     


<210>  73
<211>  1545
<212>  DNA
<213>  Streptomyces alboniger

<400>  73
gtgctcgaaa cgggctccct ggcgcccgtc ggccgccgcg tcctgctgga gtccccgccc       60

ggcgccgacc acacgcgggc ggtccgggag gtctgggagc gacacggctt ccacgtcacg      120

cacgacgaga gcgcgcacat gacccagccc ccggacgtgt actgcgtcgt ggccatcggc      180

aacgaagcac tcggcgcccg gccctcacct ccgttgcgcc gcccccacgt ggcccgggtc      240

ctgaaggcca tggcccgacg gggcgagggc cgcgccgtcc tggtcaccga cacgggcccg      300

cacgtccacg acgacgcgga gcccgaggcc gccgcacagc gggccgccga ccacgcgtgg      360

tggcagcacc tggccaagca ctgcgcgagc cggggcgtgc tcgccaacac ggtgcgcgtc      420

ggctacaccc cgttcctcgg gcacgagctg accgacgagg cggcgggtga actgctgcgc      480

cacctggtca cccgccgccc cgtcgcaccg gaggaactgg cggcggcact gcggctgctg      540

gcctcgcgcg gcttcggcaa cgtcgcgggc gagacgctgc cgctggacgg cggactcgac      600

gcgagcatcg tgcccatgcc ttcggcacgc ccaccgcgaa tggacgcgtc cgccgccgaa      660

ggtgacggcg ccgcggtgcc cgacccgttc cggctgaccg gacgtgtggt cctggtcacc      720

ggcgccagca gcgggatcgg ggcgagtatc gctcgggagt gcgcggcacg cggcgccgat      780

gtcgtcctgg ccgcgcgccg ccgcccggag ctggagaagc tcgccgccga ggtccgcgaa      840

ctgggccgca cggcctgggt gttgaccgcc gacctgtcgg atccggcgcg ggccgccgac      900

ctcgtgcacg aggcgtggga gcgtgccgga ggcgtcgacg cgctcgccta cggcgcgggc      960

gccgtctcct tcgacggctc cggtgacaac tccgccaacc gacagcagtt gctggccctc     1020

aactcgctgt cgtacgcggg tatgtgtgac gcgctgctcg aacactgggt ggctgcgggc     1080

cgaagcgggg ccgtggccgc cgtctcctcg ctggccgcgg tgagcgcgcc ggtggcgaac     1140

ctggcgagct acgggctcag caaggcggcg accgcgcagt tcaccaccca cttcgcgacc     1200

tcggcggccc ggcacaaggt gcgggccaac agcgtgcttc cgggtttcgt ccgcaccccg     1260

atgacggacg tcaccaaccc cgcgttcctg gaggccacca accggctcgt gccgaccggc     1320

cggatgagcg aggcgacaga ggtcgcggcg ctcgtctgct acctgatcag ccccgccgct     1380

gccgggctga ccggcaccca gctgcgcgtc gacggcggcg gtcactgcct ggccggactg     1440

ccgaacctgg ccccacccga gcacaccctt cgaggaagga acccggctgt gacgccctgc     1500

gtaccacgcc cccgccccgc cgtgccggaa ggggaccaca ggtga                     1545


<210>  74
<211>  514
<212>  PRT
<213>  Streptomyces alboniger

<400>  74

Val Leu Glu Thr Gly Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Ala Asp His Thr Arg Ala Val Arg Glu Val Trp 
            20                  25                  30          


Glu Arg His Gly Phe His Val Thr His Asp Glu Ser Ala His Met Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Leu 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Arg Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Leu Lys Ala Met Ala Arg Arg Gly Glu Gly Arg Ala Val Leu Val Thr 
                85                  90                  95      


Asp Thr Gly Pro His Val His Asp Asp Ala Glu Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Ala Ser Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Thr Pro 
    130                 135                 140                 


Phe Leu Gly His Glu Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
145                 150                 155                 160 


His Leu Val Thr Arg Arg Pro Val Ala Pro Glu Glu Leu Ala Ala Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Val Ala Gly Glu Thr 
            180                 185                 190         


Leu Pro Leu Asp Gly Gly Leu Asp Ala Ser Ile Val Pro Met Pro Ser 
        195                 200                 205             


Ala Arg Pro Pro Arg Met Asp Ala Ser Ala Ala Glu Gly Asp Gly Ala 
    210                 215                 220                 


Ala Val Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
                245                 250                 255     


Arg Gly Ala Asp Val Val Leu Ala Ala Arg Arg Arg Pro Glu Leu Glu 
            260                 265                 270         


Lys Leu Ala Ala Glu Val Arg Glu Leu Gly Arg Thr Ala Trp Val Leu 
        275                 280                 285             


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Asp Leu Val His Glu 
    290                 295                 300                 


Ala Trp Glu Arg Ala Gly Gly Val Asp Ala Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Val Ser Phe Asp Gly Ser Gly Asp Asn Ser Ala Asn Arg Gln Gln 
                325                 330                 335     


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Met Cys Asp Ala Leu 
            340                 345                 350         


Leu Glu His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Ala Val 
        355                 360                 365             


Ser Ser Leu Ala Ala Val Ser Ala Pro Val Ala Asn Leu Ala Ser Tyr 
    370                 375                 380                 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Thr His Phe Ala Thr 
385                 390                 395                 400 


Ser Ala Ala Arg His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
                405                 410                 415     


Val Arg Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Leu Glu Ala 
            420                 425                 430         


Thr Asn Arg Leu Val Pro Thr Gly Arg Met Ser Glu Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Leu Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
    450                 455                 460                 


Gly Thr Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
465                 470                 475                 480 


Pro Asn Leu Ala Pro Pro Glu His Thr Leu Arg Gly Arg Asn Pro Ala 
                485                 490                 495     


Val Thr Pro Cys Val Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  75
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamM polypeptide

<400>  75

Val Leu Glu Thr Gly Thr Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Ala Asp His Thr Arg Ala Val Arg Asp Val Trp 
            20                  25                  30          


Glu Arg His Gly Phe His Val Thr His Asp Glu Ser Ala His Ile Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Leu 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Arg Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Val Lys Ala Ile Ala Arg Arg Gly Glu Gly Arg Ala Val Ile Val Thr 
                85                  90                  95      


Asp Thr Gly Pro His Val His Asp Asp Ala Glu Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Ala Ser Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Phe Thr Pro 
    130                 135                 140                 


Phe Leu Gly His Glu Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
145                 150                 155                 160 


His Leu Val Thr Arg Arg Pro Val Ala Pro Glu Glu Leu Ala Gly Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Val Ala Gly Glu Thr 
            180                 185                 190         


Leu Pro Leu Asp Gly Gly Leu Asp Ala Ser Ile Leu Pro Met Pro Ser 
        195                 200                 205             


Ala Arg Pro Pro Arg Leu Asp Ala Ser Ala Ala Glu Gly Asp Gly Ala 
    210                 215                 220                 


Ala Val Pro Asp Pro Trp Arg Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
                245                 250                 255     


Arg Gly Ala Asp Val Val Leu Ala Ala Arg Arg Arg Pro Glu Leu Glu 
            260                 265                 270         


Arg Leu Ala Ala Glu Val Arg Glu Leu Gly Arg Thr Ala Trp Val Ile 
        275                 280                 285             


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Asp Leu Val His Glu 
    290                 295                 300                 


Ala Trp Glu Lys Ala Gly Gly Val Asp Ala Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Val Ser Phe Asp Gly Ser Gly Asp Asn Ser Ala Asn Arg Gln Gln 
                325                 330                 335     


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Met Cys Asp Ala Ile 
            340                 345                 350         


Leu Glu His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Ala Val 
        355                 360                 365             


Ser Ser Leu Ala Ala Val Thr Ala Pro Leu Ala Asn Leu Ala Ser Tyr 
    370                 375                 380                 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
385                 390                 395                 400 


Ser Ala Ala Arg His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Trp 
                405                 410                 415     


Val Arg Thr Pro Met Thr Glu Val Thr Asn Pro Ala Phe Leu Glu Ala 
            420                 425                 430         


Thr Asn Arg Met Val Pro Thr Gly Arg Val Ser Asp Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Met Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Ala Leu Thr 
    450                 455                 460                 


Gly Thr Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
465                 470                 475                 480 


Pro Asn Val Ala Pro Pro Glu His Thr Leu Arg Gly Arg Asn Pro Ala 
                485                 490                 495     


Val Thr Pro Cys Val Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  76
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamM polypeptide

<400>  76

Val Leu Glu Thr Gly Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Ala Asp His Thr Arg Ala Val Arg Glu Val Trp 
            20                  25                  30          


Asp Arg His Gly Phe His Val Thr His Asp Glu Ser Ala His Met Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Leu 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Arg Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Leu Arg Ala Leu Ala Arg Arg Gly Glu Gly Arg Ala Val Leu Val Ser 
                85                  90                  95      


Asp Thr Gly Pro His Val His Asp Asp Ala Glu Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Ala Ser Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Thr Pro 
    130                 135                 140                 


Phe Val Ala His Glu Leu Thr Asp Glu Ala Ala Gly Asp Met Leu Arg 
145                 150                 155                 160 


His Val Val Thr Arg Arg Pro Val Ala Pro Asp Asp Leu Ala Ala Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Val Ala Gly Glu Thr 
            180                 185                 190         


Leu Pro Leu Asp Gly Gly Leu Asp Ala Ser Ile Val Pro Met Pro Ser 
        195                 200                 205             


Ala Arg Pro Pro Arg Met Asp Ala Ser Ala Ala Glu Gly Asp Gly Ala 
    210                 215                 220                 


Ala Leu Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
                245                 250                 255     


Arg Gly Ala Asp Val Val Leu Ala Ala Arg Arg Arg Pro Glu Leu Glu 
            260                 265                 270         


Arg Ile Ala Ala Glu Val Lys Glu Leu Gly Arg Thr Ala Trp Val Leu 
        275                 280                 285             


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Asp Leu Val His Glu 
    290                 295                 300                 


Ala Trp Glu Arg Ala Gly Gly Val Asp Ala Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Val Ser Phe Asp Gly Ser Gly Glu Asn Ser Ala Asn Arg Gln Asn 
                325                 330                 335     


Leu Leu Ala Ile Asn Ser Leu Ser Phe Ala Gly Leu Cys Asp Ala Leu 
            340                 345                 350         


Leu Glu His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Ala Val 
        355                 360                 365             


Ser Ser Leu Ala Ala Val Ser Ala Pro Val Ala Asn Leu Gly Ser Tyr 
    370                 375                 380                 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Thr His Phe Ala Ser 
385                 390                 395                 400 


Ser Ala Ala Arg His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
                405                 410                 415     


Val Arg Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Leu Glu Gly 
            420                 425                 430         


Thr Asn Arg Leu Val Pro Thr Gly Arg Met Ser Glu Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Leu Val Cys Phe Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
    450                 455                 460                 


Gly Ser Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
465                 470                 475                 480 


Pro Asn Leu Ala Pro Pro Glu His Thr Leu Arg Gly Arg Asn Pro Ala 
                485                 490                 495     


Val Ser Pro Cys Val Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  77
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamM polypeptide

<400>  77

Val Leu Glu Thr Gly Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Gly Asp His Thr Arg Ala Val Arg Glu Val Trp 
            20                  25                  30          


Glu Lys His Gly Tyr His Val Thr His Asp Asp Ser Ala His Met Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Leu 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Arg Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Leu Lys Ala Met Gly Arg Arg Gly Glu Gly Arg Ala Val Val Val Thr 
                85                  90                  95      


Asp Thr Gly Pro His Val His Asp Asp Gly Glu Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Ala Ser Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Thr Pro 
    130                 135                 140                 


Phe Leu Gly His Asp Leu Thr Asp Glu Gly Ala Gly Glu Leu Leu Arg 
145                 150                 155                 160 


His Leu Val Thr Arg Arg Pro Val Ala Pro Glu Glu Leu Ala Ala Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Ala Phe Ala Asn Ile Ala Gly Glu Thr 
            180                 185                 190         


Leu Pro Leu Asp Gly Gly Val Asp Ala Ser Met Val Pro Met Pro Thr 
        195                 200                 205             


Ala Arg Pro Pro Arg Leu Asp Ala Ser Ala Ala Glu Gly Asp Ala Ala 
    210                 215                 220                 


Ala Val Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Lys Glu Cys Ala Ala 
                245                 250                 255     


Arg Gly Ala Asp Val Val Leu Ala Ala Arg Arg Arg Pro Glu Leu Glu 
            260                 265                 270         


Lys Ile Ala Ala Glu Val Lys Glu Leu Gly Arg Thr Ala Trp Val Leu 
        275                 280                 285             


Thr Ala Asp Leu Thr Asp Pro Ala Arg Ala Ala Asp Leu Val His Glu 
    290                 295                 300                 


Ala Trp Glu Lys Ala Gly Gly Val Asp Gly Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Ile Ser Phe Asp Gly Ser Gly Asp Asn Ser Ala Asn Arg Gln Gln 
                325                 330                 335     


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Met Cys Asp Ala Val 
            340                 345                 350         


Leu Asp His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Gly Val 
        355                 360                 365             


Ser Ser Ile Ala Ala Ile Ser Ala Pro Val Ala Asn Leu Ala Ser Tyr 
    370                 375                 380                 


Gly Leu Ser Lys Ala Ala Thr Ala Asn Phe Thr Thr His Phe Ala Thr 
385                 390                 395                 400 


Ser Ala Ala Arg His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
                405                 410                 415     


Val Arg Thr Pro Met Thr Asp Val Thr Asn Pro Gly Phe Leu Glu Ala 
            420                 425                 430         


Thr Asn Arg Leu Ile Pro Thr Gly Arg Met Ser Glu Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Leu Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Val Thr 
    450                 455                 460                 


Gly Thr Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
465                 470                 475                 480 


Pro Gln Leu Ala Pro Pro Glu His Thr Ile Arg Gly Arg Asn Pro Ala 
                485                 490                 495     


Val Thr Pro Cys Leu Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  78
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamM polypeptide

<400>  78

Val Leu Glu Thr Gly Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Ala Asp His Thr Arg Ala Val Arg Glu Val Trp 
            20                  25                  30          


Glu Arg His Gly Phe His Val Thr His Glu Glu Ser Ala His Ile Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Leu 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Lys Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Leu Lys Ala Met Ala Arg Arg Gly Glu Gly Arg Ala Val Val Val Thr 
                85                  90                  95      


Asp Thr Ala Pro His Val His Asp Asp Gly Glu Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Gly Ser Arg Gly Val Leu Ala Asn Thr Val Arg Val Ala Tyr Thr Pro 
    130                 135                 140                 


Phe Leu Ala His Glu Leu Thr Asp Glu Ala Ala Gly Glu Leu Ile Lys 
145                 150                 155                 160 


His Leu Val Thr Arg Arg Pro Leu Ala Pro Glu Glu Leu Ala Ala Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Ala Phe Ala Asn Ile Ala Gly Glu Thr 
            180                 185                 190         


Val Pro Ile Asp Gly Gly Leu Asp Ala Ser Ile Val Pro Leu Pro Thr 
        195                 200                 205             


Ala Lys Pro Pro Arg Met Asp Ala Ser Ala Gly Glu Ala Asp Ala Ala 
    210                 215                 220                 


Ala Val Pro Glu Pro Tyr Lys Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Val Ala Arg Glu Cys Ala Ala 
                245                 250                 255     


Arg Gly Ala Asp Val Ile Leu Ala Ala Arg Arg Arg Pro Glu Leu Glu 
            260                 265                 270         


Lys Val Ala Ala Glu Val Arg Glu Leu Gly Arg Thr Ala Phe Val Val 
        275                 280                 285             


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Gly Asp Met Met His Glu 
    290                 295                 300                 


Ala Trp Glu Arg Ala Gly Ala Val Asp Ala Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Leu Ser Phe Asp Gly Ser Gly Asp Asn Ser Ala Asn Arg Gln Gln 
                325                 330                 335     


Leu Leu Ala Val Asn Ser Ile Ser Tyr Ala Gly Met Cys Asp Ala Leu 
            340                 345                 350         


Leu Asp His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Ala Val 
        355                 360                 365             


Ser Ser Leu Ala Ala Ile Ser Ala Pro Val Gly Asn Leu Ala Ser Tyr 
    370                 375                 380                 


Ala Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Thr His Phe Ala Ser 
385                 390                 395                 400 


Ser Ala Ala Arg His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
                405                 410                 415     


Val Lys Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Val Glu Ala 
            420                 425                 430         


Thr Asn Lys Ile Val Pro Thr Gly Arg Met Ser Glu Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Val Val Cys Tyr Leu Ile Ser Pro Gly Ala Ala Gly Ile Thr 
    450                 455                 460                 


Gly Thr Gln Leu Arg Val Asp Gly Gly Gly His Cys Val Ala Gly Leu 
465                 470                 475                 480 


Pro Asn Met Ala Pro Pro Glu His Thr Leu Arg Gly Arg Asn Pro Ala 
                485                 490                 495     


Val Thr Pro Cys Val Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  79
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamM polypeptide

<400>  79

Val Leu Glu Thr Gly Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
1               5                   10                  15      


Glu Ser Pro Pro Gly Ala Asp His Thr Arg Ala Val Arg Glu Val Trp 
            20                  25                  30          


Glu Arg His Gly Phe His Val Thr His Glu Asp Ser Ala His Val Thr 
        35                  40                  45              


Gln Pro Pro Asp Val Tyr Cys Val Val Ala Ile Gly Asn Glu Ala Val 
    50                  55                  60                  


Gly Ala Arg Pro Ser Pro Pro Leu Lys Arg Pro His Val Ala Arg Val 
65                  70                  75                  80  


Leu Arg Ala Met Gly Arg Arg Gly Glu Gly Arg Ala Val Leu Val Thr 
                85                  90                  95      


Asp Thr Gly Pro His Val His Asp Asp Ala Asp Pro Glu Ala Ala Ala 
            100                 105                 110         


Gln Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys His Cys 
        115                 120                 125             


Ala Ser Lys Gly Val Leu Ala Asn Thr Val Arg Val Gly Phe Thr Pro 
    130                 135                 140                 


Phe Leu Gly His Glu Leu Ser Asp Glu Ala Ala Ala Glu Leu Met Arg 
145                 150                 155                 160 


His Leu Val Thr Arg Arg Pro Val Ala Pro Glu Glu Leu Ala Ala Ala 
                165                 170                 175     


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Val Ala Gly Glu Thr 
            180                 185                 190         


Leu Pro Val Asp Gly Gly Leu Asp Ala Ser Val Ile Pro Leu Pro Ser 
        195                 200                 205             


Ala Arg Pro Pro Arg Met Asp Gly Ser Gly Ala Glu Gly Glu Gly Ala 
    210                 215                 220                 


Ala Val Pro Asp Pro Tyr Arg Leu Thr Gly Arg Val Val Leu Val Thr 
225                 230                 235                 240 


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
                245                 250                 255     


Lys Gly Ala Asp Val Val Leu Ala Gly Arg Lys Arg Pro Glu Leu Glu 
            260                 265                 270         


Lys Leu Ala Ala Glu Val Arg Glu Leu Gly Arg Thr Ala Phe Val Ile 
        275                 280                 285             


Thr Ala Asp Leu Thr Asp Pro Ala Arg Ala Ala Asp Leu Leu His Glu 
    290                 295                 300                 


Ala Trp Glu Lys Ala Gly Ala Val Asp Ala Leu Ala Tyr Gly Ala Gly 
305                 310                 315                 320 


Ala Val Ser Trp Asp Gly Ser Gly Asp Asn Ser Ala Asn Arg Gln Gln 
                325                 330                 335     


Val Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Met Cys Asp Ala Leu 
            340                 345                 350         


Leu Glu His Trp Val Ala Ala Gly Arg Ser Gly Ala Val Ala Ala Val 
        355                 360                 365             


Ser Ser Met Ala Ala Val Ser Ala Pro Val Ala Asn Leu Ala Ser Tyr 
    370                 375                 380                 


Ala Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Thr His Phe Ala Thr 
385                 390                 395                 400 


Ser Ala Gly Lys His Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
                405                 410                 415     


Val Lys Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Val Glu Ala 
            420                 425                 430         


Thr Asn Arg Val Leu Pro Thr Gly Arg Leu Ser Glu Ala Thr Glu Val 
        435                 440                 445             


Ala Ala Val Val Cys Tyr Leu Ile Thr Pro Ala Ala Ala Gly Val Thr 
    450                 455                 460                 


Gly Ser Asn Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Ile 
465                 470                 475                 480 


Pro Gln Ile Ala Pro Pro Asp His Thr Leu Arg Gly Arg Gln Pro Ala 
                485                 490                 495     


Val Ser Pro Cys Val Pro Arg Pro Arg Pro Ala Val Pro Glu Gly Asp 
            500                 505                 510         


His Arg 
        


<210>  80
<211>  828
<212>  DNA
<213>  Streptomyces alboniger

<400>  80
gtgaccgagg acaggcccct caagggcaag gtggcgctgg tcgccggcgc ctcgtccggc       60

atcggggcga gcatcgcccg cgcgctggcg gcggccggcg cctctgtcgc cctcgtcgcc      120

cgccgcaagg accaactggc ctgcgtcgag cgcgacgtgg ccgggcacga ggtgcccgcc      180

gtcacgctca tcgccgacct gtcggccgac ggcgtgccca aggagacggt gaccgccgcc      240

gagcgggccc tcggccccgt cgacatcctg gtgaacaacg ccgccctggc tcgcaccgga      300

cccatccacg acaccaaccc ccgccactgg cggcaggcct tccacctcaa tctggacgtc      360

cccttcctgc tggcccgcac ggtgctcccc gggatgcgcg agcgcggcca cggctggatc      420

gtcaacatca gctcggaggg cagtctccta caggccgact ggtcggcccc gtactccatc      480

accaaacgcg ccctgaacgc gctgaccgcg caaatcgacc tggagaaccg gcacttgggg      540

gtccgcgcca tcgccgtgct gcccggctgg gtgcgcacgg acctggcgca ggaccccgag      600

tcgctggggg tgggtgtcac ggatctgctg gacccctcgg acatcgccga tgtcgtgctg      660

tgggccatca cccgcccgcc cgctgtcagc atcggcccgc tgataccggt acgccccgtc      720

agcaggagtg cccagacctt ggtcaactgg gagcagtacc tgcggacgct gcgccattac      780

gacgcctccg gcggtcacat ggtcgacgtg cccgggatcc ctgaatga                   828


<210>  81
<211>  275
<212>  PRT
<213>  Streptomyces alboniger

<400>  81

Val Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Val Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Val Glu Arg Asp Val Ala Gly His Glu Val Pro Ala Val Thr Leu Ile 
    50                  55                  60                  


Ala Asp Leu Ser Ala Asp Gly Val Pro Lys Glu Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Arg Thr Gly Pro Ile His Asp Thr Asn Pro Arg His Trp Arg Gln 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Ser Leu Gly Val Gly Val Thr Asp 
        195                 200                 205             


Leu Leu Asp Pro Ser Asp Ile Ala Asp Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Ser Ala Gln Thr Leu Val Asn Trp Glu Gln Tyr Leu Arg Thr 
                245                 250                 255     


Leu Arg His Tyr Asp Ala Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  82
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamN polypeptide

<400>  82

Val Thr Glu Asp Lys Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Thr Val Ala Leu Val Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Val Glu Arg Asp Val Ala Gly His Glu Val Pro Ala Met Ser Leu Ile 
    50                  55                  60                  


Ala Asp Leu Ser Ala Asp Gly Val Pro Lys Glu Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Arg Ser Gly Pro Ile His Asp Thr Asn Pro Arg His Trp Arg Asn 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Asn Asp Pro Glu Ser Ile Gly Leu Ala Val Thr Asp 
        195                 200                 205             


Met Leu Glu Pro Ser Asp Ile Ala Asp Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Ser Ala Gln Thr Leu Val Asn Trp Glu Gln Tyr Leu Arg Thr 
                245                 250                 255     


Met Arg His Tyr Asp Ala Ser Gly Gly His Met Ile Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  83
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamN polypeptide

<400>  83

Val Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Ile Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Ile Glu Lys Asp Val Ala Gly His Glu Val Pro Ala Val Thr Leu Ile 
    50                  55                  60                  


Gly Asp Leu Ser Ala Asp Gly Val Pro Lys Glu Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Ile 
                85                  90                  95      


Ala Arg Thr Gly Pro Val His Asp Thr Asn Pro Arg His Trp Arg Gln 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Lys Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Ala Ser Leu Ile Gln Ala Asp Phe Thr Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Val Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Lys Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Ser Leu Gly Val Gly Val Thr Asp 
        195                 200                 205             


Leu Leu Asp Pro Ser Asp Ile Ala Asp Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Ser Ala Gln Thr Leu Val Asn Trp Glu Gln Tyr Val Arg Thr 
                245                 250                 255     


Leu Arg His Tyr Asp Ala Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  84
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamN polypeptide

<400>  84

Val Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Leu Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Val Glu Arg Glu Val Ala Gly His Glu Val Pro Ala Val Thr Leu Ile 
    50                  55                  60                  


Ala Asp Leu Ser Ala Asp Ala Val Pro Lys Glu Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Lys Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Ile 
                85                  90                  95      


Ala Arg Thr Gly Pro Leu His Asp Thr Asn Pro Arg His Trp Arg Gln 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Ala His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Asp Gly Ser Met Val Gln Ala Asp Tyr Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Ser Leu Gly Ile Ala Val Thr Asp 
        195                 200                 205             


Leu Ile Asp Pro Ser Asp Ile Ala Glu Val Val Val Phe Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Leu Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Ser Ala Asn Thr Leu Val Asn Trp Glu Gln Tyr Leu Arg Thr 
                245                 250                 255     


Leu Arg His Tyr Asp Gly Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  85
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamN polypeptide

<400>  85

Val Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Ile Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Leu Glu Arg Asp Ile Ala Gly His Glu Val Pro Ala Val Thr Leu Ile 
    50                  55                  60                  


Ala Asp Leu Ser Ala Asp Gly Val Pro Lys Asp Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Arg Thr Ala Pro Leu His Glu Thr Asn Pro Arg His Trp Arg Gln 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Lys Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Val Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Leu Glu Asn 
                165                 170                 175     


Arg His Met Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Gly Gln Asp Pro Asp Ser Leu Gly Val Gly Val Thr Asp 
        195                 200                 205             


Ile Val Asp Pro Ser Asp Ile Ala Asp Leu Val Val Phe Ala Ile Thr 
    210                 215                 220                 


Lys Pro Pro Gly Leu Ser Ile Gly Pro Leu Ile Pro Met Arg Pro Val 
225                 230                 235                 240 


Ser Arg Thr Ala Gln Thr Val Val Asn Trp Glu Gln Tyr Leu Arg Thr 
                245                 250                 255     


Leu Lys His Tyr Glu Gly Ser Gly Ala His Met Leu Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  86
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamN polypeptide

<400>  86

Val Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Ala Leu Ala Ala Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Val Ala Arg Arg Lys Asp Gln Leu Ala Cys 
        35                  40                  45              


Leu Glu Arg Asp Val Ala Ala His Glu Leu Pro Ala Ile Thr Leu Val 
    50                  55                  60                  


Ala Asp Leu Ser Ala Asp Gly Val Pro Lys Glu Thr Val Thr Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Val 
                85                  90                  95      


Ala Arg Thr Gly Pro Leu His Asp Thr Asn Pro Arg His Trp Arg Gln 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Thr Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Ile Gln Ala Asp Trp Thr Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Ile Asp Val Glu Asn 
                165                 170                 175     


Lys His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Lys 
            180                 185                 190         


Thr Asp Met Ala Gln Asp Pro Glu Thr Leu Gly Val Ala Val Thr Asp 
        195                 200                 205             


Val Leu Glu Pro Ser Asp Ile Ala Asp Ile Val Met Phe Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Thr Ala Gln Thr Leu Ile Asn Trp Glu Gln Tyr Val Arg Thr 
                245                 250                 255     


Met Arg His Phe Asp Ala Thr Ala Gly His Met Val Glu Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  87
<211>  1704
<212>  DNA
<213>  Streptomyces alboniger

<400>  87
atgacgggcc ccacgacgtc agcggccacg gcggcgcggg atctcgacgt ggcggccgac       60

cgcctcgtcg agatcctccc gccgggggac gcacgggtac cggacgccga gcactgcgtc      120

acgggcgcgc tgctcgccgc ccgcgccgag gcccatcccg accgcgtgta cgccgtcttc      180

gaggacggca cccactggac gtacgggcag gcctacgacg acgcgcgcac caccgccgcc      240

gccctgtacc ggctgggcgt gcgtcagggc gacaccgtgc tgtgctggct gcccaacggc      300

ctggacgcgc tgcgcgtctg gtacggcgtc aatctcctcg gcgccgtcca cgtccctgtc      360

aacaccgcct atcggggcgc gctcctggaa cacgtactgg acaactccgg ggcccgggtc      420

cttgtggtgc acgcgctgct cgtcgagcgg ctccagcaca tcggcgacag ccgcctccag      480

gaggtcgtcg tcctcggcgg cggaccggac gcgccctggc cggacgccct gcccggtgcc      540

ccgcgcgtgc acggtcccgc ggcgctgcgg ggcctgccgg aggacttcgt cccgcccgag      600

cggccggtcg cgccctggga caccatggcg gtgatctaca cctcgggcac caccggcccg      660

tccaagggcg tcctggtctc ctacgtccat cactactcga cggtgaccgc gctcctcgac      720

gacgacatcg gcgaggacga ccggtatctg ctcaacctgc cgctgtgcca cggcggcggt      780

accgaagtcg cctactgcat gctcctgttc gggggctcga tcgtcgtcac cgagaacttc      840

cgcaccggcg agttctggga cgtggtgcgc cgccacgggg tgaccatgtg caccctgctc      900

ggcgccatgg tcgacttcct gctcggtctg gccccccggc cggacgaggc cgaacacccg      960

ctgcgggccg cgtgcgtgat accgctgacg cgccaggccc tggacttcgg ccgccgcttc     1020

ggcgtggacg tctacaccgg gttcaacatg tccgagacct cggcgccgct ggtgtcaccg     1080

ctcaatccgc agcgcacggg cagctgcggg cggccgcggc cgggggtgca gtgccgggtg     1140

gtcgacgcga acggcatcga cgtacccgac ggcagcgtgg gcgagctggt gctgcgcgcc     1200

gaccggccgt ggtcgctgtt ccacggctac cacgccatgc cggaggccac cgcgggggca     1260

tggcggcacg gctggttccg caccggggac gccgtggtgc gtgagcccgg cggcgactac     1320

ttcttcgtgg accgcatcaa ggacgccatc cggcgccgcg gcgagaacgt gtcctcgatg     1380

gaggtcgaag ccgagttgct gagccatccc gccgtggcgt tcgccgccgc cgtggcggtg     1440

cccagcgact tcgccgagga cgagatactc gccgccctcg tgctccggcc cggggcccgt     1500

ttcgaaccgg aggagttcat cgggtacctg cggcctcgca tggcgcactt catggtgccg     1560

cgctatctgc gtgtcctgtc cgagcttccc gtgacggaca cgggcaaggt ccgcaaggag     1620

acgctgcgcg cccagggcgt cacccccgac acctgggacc gcgtggcggc cgggatcgag     1680

gtcacccgtg accgcatccg ctga                                            1704


<210>  88
<211>  567
<212>  PRT
<213>  Streptomyces alboniger

<400>  88

Met Thr Gly Pro Thr Thr Ser Ala Ala Thr Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Val Ala Ala Asp Arg Leu Val Glu Ile Leu Pro Pro Gly Asp Ala Arg 
            20                  25                  30          


Val Pro Asp Ala Glu His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Arg Val Tyr Ala Val Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Gly Gln Ala Tyr Asp Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Tyr Arg Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
                85                  90                  95      


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Glu His Val Leu Asp Asn Ser Gly Ala Arg Val Leu Val Val His 
    130                 135                 140                 


Ala Leu Leu Val Glu Arg Leu Gln His Ile Gly Asp Ser Arg Leu Gln 
145                 150                 155                 160 


Glu Val Val Val Leu Gly Gly Gly Pro Asp Ala Pro Trp Pro Asp Ala 
                165                 170                 175     


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Leu Arg Gly Leu 
            180                 185                 190         


Pro Glu Asp Phe Val Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
225                 230                 235                 240 


Asp Asp Ile Gly Glu Asp Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Glu Asn Phe Arg Thr Gly Glu Phe Trp Asp Val 
        275                 280                 285             


Val Arg Arg His Gly Val Thr Met Cys Thr Leu Leu Gly Ala Met Val 
    290                 295                 300                 


Asp Phe Leu Leu Gly Leu Ala Pro Arg Pro Asp Glu Ala Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Leu Asp Phe 
                325                 330                 335     


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Ser Ala Pro Leu Val Ser Pro Leu Asn Pro Gln Arg Thr Gly Ser 
        355                 360                 365             


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Asp Val Pro Asp Gly Ser Val Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Ala Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Gly Ala Trp Arg His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Val Arg Glu Pro Gly Gly Asp Tyr Phe Phe Val Asp Arg Ile Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Leu Ser His Pro Ala Val Ala Phe Ala Ala Ala Val Ala Val 
465                 470                 475                 480 


Pro Ser Asp Phe Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Arg 
                485                 490                 495     


Pro Gly Ala Arg Phe Glu Pro Glu Glu Phe Ile Gly Tyr Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Val Pro Arg Tyr Leu Arg Val Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Gly Ile Glu 
545                 550                 555                 560 


Val Thr Arg Asp Arg Ile Arg 
                565         


<210>  89
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamL polypeptide

<400>  89

Met Thr Gly Pro Thr Thr Ser Ala Ala Thr Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Met Ala Ala Asp Lys Leu Leu Glu Ile Leu Pro Pro Gly Asp Gly Arg 
            20                  25                  30          


Val Pro Asp Ala Glu His Cys Val Thr Ala Ala Met Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Arg Ile Tyr Ala Val Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Gly Gln Ala Tyr Asp Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Tyr Arg Leu Gly Val Lys Gln Gly Asp Thr Val Leu Cys Phe 
                85                  90                  95      


Val Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Glu His Val Leu Asp Asn Ser Gly Ala Arg Val Leu Val Val His 
    130                 135                 140                 


Ala Leu Leu Val Asp Arg Leu Gln His Ile Gly Asp Ser Arg Leu Gln 
145                 150                 155                 160 


Glu Val Val Val Leu Gly Ala Ala Pro Asp Ala Pro Trp Pro Asp Ala 
                165                 170                 175     


Leu Pro Gly Gly Pro Arg Val His Gly Pro Ala Ala Leu Arg Gly Leu 
            180                 185                 190         


Pro Glu Asp Phe Val Pro Pro Glu Arg Pro Ile Ala Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Leu Val Ser Tyr Val His His Tyr Ser Thr Leu Thr Ala Ile Leu Asp 
225                 230                 235                 240 


Asp Asp Leu Gly Glu Asp Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Gly Gly Thr Glu Val Ala Phe Cys Met Leu Leu Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Glu Asn Phe Arg Thr Gly Glu Phe Tyr Asp Val 
        275                 280                 285             


Val Lys Arg His Gly Val Thr Met Cys Thr Leu Leu Gly Ala Met Val 
    290                 295                 300                 


Glu Phe Leu Leu Gly Leu Ala Pro Arg Pro Asp Glu Ala Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Lys Gln Ala Leu Asp Phe 
                325                 330                 335     


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Ser Ala Pro Leu Val Ser Pro Leu Asn Pro Gln Arg Thr Gly Ser 
        355                 360                 365             


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Asp Val Pro Asp Gly Ser Val Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Trp Thr Leu Phe His Gly Tyr His Ala Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Gly Ala Trp Arg His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Val Arg Glu Pro Gly Gly Asp Tyr Phe Phe Val Asp Arg Ile Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Leu Ser His Pro Ala Val Ala Phe Ala Ala Ala Val Ala Val 
465                 470                 475                 480 


Pro Ser Asp Phe Ala Glu Glu Glu Ile Leu Ala Ala Leu Val Leu Arg 
                485                 490                 495     


Pro Gly Ala Arg Phe Glu Pro Glu Glu Phe Ile Ala Trp Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Val Pro Lys Tyr Leu Arg Val Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Ala Ile Glu 
545                 550                 555                 560 


Val Thr Arg Asp Arg Ile Arg 
                565         


<210>  90
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamL polypeptide

<400>  90

Met Thr Gly Pro Thr Thr Ser Ala Ala Thr Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Val Ala Ala Asp Arg Leu Ile Glu Val Leu Pro Pro Gly Asp Gly Arg 
            20                  25                  30          


Val Pro Asp Ala Glu His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Arg Val Tyr Ala Leu Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Gly Gln Ala Tyr Asp Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Tyr Arg Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
                85                  90                  95      


Leu Pro Asn Gly Val Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Ile 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Glu His Ile Leu Asp Asn Ser Gly Ala Arg Val Leu Val Val His 
    130                 135                 140                 


Ala Leu Leu Val Glu Arg Met Gln His Ile Gly Glu Ser Arg Leu Gln 
145                 150                 155                 160 


Glu Val Leu Val Leu Gly Gly Gly Pro Asp Ala Pro Phe Pro Asp Ala 
                165                 170                 175     


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Leu Lys Ala Leu 
            180                 185                 190         


Pro Glu Asp Phe Val Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Met Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
225                 230                 235                 240 


Asp Asp Val Gly Glu Asp Asp Arg Tyr Leu Ile Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Glu Asn Phe Arg Thr Gly Glu Phe Trp Asp Val 
        275                 280                 285             


Val Arg Arg His Gly Val Thr Leu Cys Thr Leu Leu Gly Ala Met Val 
    290                 295                 300                 


Asp Phe Leu Leu Gly Leu Ala Pro Arg Pro Glu Glu Ala Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Ile Thr Arg Gln Ala Leu Asp Phe 
                325                 330                 335     


Gly Arg Arg Phe Gly Ile Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Thr Ala Pro Leu Val Ser Pro Leu Asn Pro Gln Arg Ser Gly Ser 
        355                 360                 365             


Cys Gly Lys Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Asp Val Pro Asp Gly Ser Val Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Ala Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Gly Ala Trp Arg His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Val Arg Glu Pro Gly Gly Glu Tyr Phe Phe Val Asp Arg Ile Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Leu Ser His Pro Ala Val Ala Phe Ala Ala Ala Val Ala Leu 
465                 470                 475                 480 


Pro Ser Asp Phe Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Lys 
                485                 490                 495     


Pro Gly Ala Arg Phe Glu Pro Glu Glu Phe Ile Gly Tyr Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Leu Pro Arg Tyr Leu Arg Val Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Gly Val Thr Pro Asp Thr Phe Asp Arg Val Ala Ala Gly Ile Glu 
545                 550                 555                 560 


Leu Thr Arg Asp Arg Ile Arg 
                565         


<210>  91
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamL polypeptide

<400>  91

Met Thr Gly Pro Thr Thr Ser Ala Ala Thr Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Leu Ala Ala Asp Lys Leu Val Glu Leu Ile Pro Pro Gly Glu Ala Arg 
            20                  25                  30          


Ile Pro Asp Ala Glu His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Arg Val Tyr Ala Val Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Ala Gln Ala Tyr Glu Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Tyr Arg Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
                85                  90                  95      


Leu Pro Asn Gly Leu Glu Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Glu His Ile Leu Asp Asn Ser Gly Ala Arg Val Leu Val Val His 
    130                 135                 140                 


Ala Leu Val Val Glu Arg Leu Gln His Ile Gly Asp Ser Arg Met Asn 
145                 150                 155                 160 


Glu Ile Val Val Leu Gly Gly Gly Pro Asp Gly Pro Tyr Pro Asp Ala 
                165                 170                 175     


Ile Pro Ala Ala Pro Arg Val His Gly Pro Ala Ala Leu Arg Ala Leu 
            180                 185                 190         


Pro Glu Asp Phe Val Pro Pro Glu Lys Pro Val Ala Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Leu Val Ser Tyr Val His His Tyr Ser Thr Leu Thr Gly Leu Val Asp 
225                 230                 235                 240 


Asp Asp Leu Gly Asp Asp Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Ala Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Glu Asn Phe Arg Thr Gly Glu Phe Trp Asp Val 
        275                 280                 285             


Val Arg Arg His Gly Val Thr Met Cys Ser Leu Leu Gly Ala Met Val 
    290                 295                 300                 


Asp Tyr Leu Ile Gly Leu Ala Pro Arg Pro Glu Glu Ala Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Val Asp Phe 
                325                 330                 335     


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Ser Ala Pro Leu Val Ser Pro Leu Asn Pro Gln Arg Thr Gly Ser 
        355                 360                 365             


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Asp Val Pro Asp Gly Ser Val Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Ala Ala Trp Arg His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Val Arg Glu Pro Gly Gly Asp Tyr Tyr Phe Ile Asp Arg Leu Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Leu Ser His Pro Gly Val Ala Phe Ala Ala Ala Val Ala Val 
465                 470                 475                 480 


Pro Ser Asp Tyr Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Val Arg 
                485                 490                 495     


Pro Gly Ala Arg Phe Glu Pro Glu Glu Phe Ile Gly Tyr Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Val Pro Arg Tyr Leu Arg Val Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Ala Ile Glu 
545                 550                 555                 560 


Val Thr Arg Asp Arg Ile Arg 
                565         


<210>  92
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamL polypeptide

<400>  92

Met Thr Gly Pro Thr Thr Ser Ala Ala Thr Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Val Ala Ala Asp Arg Leu Val Glu Ile Ile Pro Pro Gly Asp Ala Arg 
            20                  25                  30          


Val Pro Asp Ala Glu His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Arg Ile Tyr Ala Val Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Ala Gln Ala Tyr Glu Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Gly Leu Tyr Arg Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
                85                  90                  95      


Met Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Glu His Val Leu Asp Asn Ser Gly Ala Arg Leu Leu Val Val His 
    130                 135                 140                 


Gly Leu Val Val Glu Arg Ile Gln His Ile Gly Asp Ser Arg Leu Gln 
145                 150                 155                 160 


Glu Leu Ile Val Leu Gly Gly Gly Pro Asp Ala Pro Trp Pro Asp Ala 
                165                 170                 175     


Leu Pro Ala Ala Pro Arg Ile His Gly Pro Ala Ala Ile Arg Ala Leu 
            180                 185                 190         


Pro Asp Asp Phe Val Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Leu Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Ile Ile Ser Tyr Val His His Tyr Ser Ser Ile Ser Ala Val Leu Asp 
225                 230                 235                 240 


Asp Asp Ile Gly Glu Glu Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Asp Asn Phe Arg Thr Gly Glu Phe Phe Asp Leu 
        275                 280                 285             


Val Arg Arg His Gly Val Thr Ile Cys Thr Leu Leu Gly Gly Ile Val 
    290                 295                 300                 


Asp Phe Leu Leu Gly Leu Ala Pro Arg Pro Glu Glu Gly Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Ile Asp Tyr 
                325                 330                 335     


Gly Arg Arg Trp Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Ser Ala Pro Ile Val Ser Pro Leu Asn Pro Asn Arg Ser Gly Ser 
        355                 360                 365             


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Asp Val Pro Glu Gly Ser Met Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Tyr Ser Leu Phe His Gly Tyr His Ala Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Gly Ala Trp Arg His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Val Arg Glu Pro Gly Gly Asp Tyr Phe Phe Leu Asp Arg Val Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Ile Ser His Pro Gly Val Ala Phe Ala Ala Ala Val Ala Val 
465                 470                 475                 480 


Pro Ser Asp Phe Ala Glu Asp Glu Ile Ile Ala Ala Leu Val Leu Arg 
                485                 490                 495     


Pro Gly Ala Arg Phe Asp Pro Glu Glu Phe Ile Gly Phe Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Ile Pro Arg Tyr Leu Arg Leu Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Ala Val Thr Pro Asp Thr Phe Glu Arg Val Ala Gly Ala Met Glu 
545                 550                 555                 560 


Val Thr Arg Asp Arg Ile Arg 
                565         


<210>  93
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamL polypeptide

<400>  93

Met Thr Gly Pro Thr Thr Ser Ala Ala Ser Ala Ala Arg Asp Leu Asp 
1               5                   10                  15      


Met Ala Ala Asp Lys Leu Leu Glu Ile Leu Pro Pro Gly Asp Ala Arg 
            20                  25                  30          


Met Pro Asp Ala Glu His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
        35                  40                  45              


Ala Glu Ala His Pro Asp Lys Val Tyr Ala Val Phe Glu Asp Gly Thr 
    50                  55                  60                  


His Trp Thr Tyr Ala Gln Ala Tyr Asp Asp Ala Arg Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Leu Tyr Arg Val Gly Val Arg Gln Gly Asp Thr Val Leu Cys Phe 
                85                  90                  95      


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
            100                 105                 110         


Leu Gly Ala Val His Val Pro Val Asn Thr Gly Tyr Arg Gly Ala Leu 
        115                 120                 125             


Leu Asp His Ile Leu Asp Asn Ser Gly Ala Lys Val Leu Val Val His 
    130                 135                 140                 


Ala Val Leu Val Glu Arg Leu Gln His Ile Gly Asp Ser Arg Ile Gln 
145                 150                 155                 160 


Glu Val Ile Val Ile Gly Gly Ala Pro Asp Ala Pro Trp Pro Asp Ala 
                165                 170                 175     


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Leu Arg Gly Leu 
            180                 185                 190         


Pro Glu Asp Phe Leu Pro Pro Glu Arg Pro Met Gly Pro Trp Asp Thr 
        195                 200                 205             


Met Ala Val Val Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
    210                 215                 220                 


Ile Met Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
225                 230                 235                 240 


Glu Asp Leu Gly Glu Asp Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
                245                 250                 255     


His Gly Ala Gly Ser Glu Val Ala Phe Cys Met Leu Ile Phe Gly Gly 
            260                 265                 270         


Ser Ile Val Val Thr Glu Asn Phe Arg Thr Gly Asp Phe Trp Glu Leu 
        275                 280                 285             


Val Arg Arg His Gly Val Thr Leu Cys Thr Leu Leu Gly Ala Ile Val 
    290                 295                 300                 


Asp Phe Leu Met Gly Leu Ala Pro Arg Pro Asp Glu Ala Glu His Pro 
305                 310                 315                 320 


Leu Arg Ala Ala Cys Val Ile Pro Ile Ser Lys Gln Ala Leu Asp Phe 
                325                 330                 335     


Gly Arg Arg Tyr Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
            340                 345                 350         


Thr Ser Ala Pro Val Ile Ser Pro Leu Asn Pro Gln Lys Thr Gly Thr 
        355                 360                 365             


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Lys Val Val Asp Ala Asn 
    370                 375                 380                 


Gly Ile Glu Val Pro Asp Gly Thr Val Gly Glu Leu Val Leu Arg Ala 
385                 390                 395                 400 


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Ala Met Pro Glu Ala 
                405                 410                 415     


Thr Ala Gly Ala Trp Lys His Gly Trp Phe Arg Thr Gly Asp Ala Val 
            420                 425                 430         


Leu Arg Glu Pro Gly Gly Asp Tyr Tyr Phe Val Asp Arg Leu Lys Asp 
        435                 440                 445             


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Met Glu Val Glu Ala 
    450                 455                 460                 


Glu Leu Leu Ser His Pro Ala Val Ala Phe Ala Ala Ala Val Ala Val 
465                 470                 475                 480 


Pro Ser Asp Phe Gly Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Arg 
                485                 490                 495     


Pro Gly Ala Arg Phe Glu Pro Glu Glu Phe Ile Gly Trp Leu Arg Pro 
            500                 505                 510         


Arg Met Ala His Phe Met Leu Pro Arg Tyr Leu Arg Leu Leu Ser Glu 
        515                 520                 525             


Leu Pro Val Thr Asp Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
    530                 535                 540                 


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Gly Ile Glu 
545                 550                 555                 560 


Val Thr Lys Glu Arg Ile Arg 
                565         


<210>  94
<211>  1347
<212>  DNA
<213>  Streptomyces alboniger

<400>  94
gtgattgacc ccgccgacta cgccctgtgg aacagcggcg tgccgcgccc gtacctcaag       60

gcgctgtccc gcgacgacct gctcaccgag ggcgacggcg tgcgcgtccg tgactccggt      120

ggccgctggt acctggacgg ccgctccggg ctgtggaacg tgacgctcgg ctacggcaac      180

acccgcgtca aggaggccat caagcagcag gtggaccggc tgccgttcgc caacagctac      240

ggctacggac gtcccgcgca ggtcaccgtg gactgcgccg aggccctcgt ccgtcatctg      300

cccgagggca tcaaccacgt ccggttcgcc agcaacgggg cccaggcggt ggagatggcc      360

ctccagctgt cgcgcttcct gcggctgcgg gccgggcagc ccgagcgcat ggccgtgttc      420

gccatgtggg acggcttcca cgggcagggg ccgggcgccg gcatggtgac cggtgtcccc      480

tacctgcacc accagaccgg gccgatgctc cccgaggtgc accacgctcc cggcccgttc      540

tcggcgggcg cgacgcaggg cgtcagcgac atggaacggc tgatcaccga gttcggcccc      600

gagcgggtga ccgcggtgat cgtggagccc gtcgtcggcg agggcggcca catcctgtcc      660

cccgagtacc tcggctccct gggccggttc tgccgtcagc acgacatcca tctgatcttc      720

gacgaggtcg tcaccggcat gggccgggtc ggcgacttca cccgcgccgg ccaactgccc      780

gatgtcaccc ccgacatcat caccctgggc aagggcatca cctcggggta cgtgccgatg      840

tcggccgtcg ccatccacga ccgcctctac gagcagctgc acgagcgcac cacgggcgac      900

accgcgctca gcgtcggctc gaccaacgac ggccacgcgg tggccgctgc ggcggcgctc      960

gcggtgatcg gggcgctcac cgaggacggc gtgctggaga acgtacgccg ccgtgaggct     1020

gatctcctct ccgccctggg caagctccag gcccagcacc ccgagctgag ggccttccgc     1080

gctctcggcc tgttctgcgg cctggagctc ggcgagcccg gcggtccgtc gtggtccccg     1140

ggcaaggtga accagctgcg catgaccttg gagagccgag gcgtgctcag ctccagcctg     1200

cgtgtcgtac cgaatctgat gctcatgccg ccgctggtca tcaccgagga cgacgtggcg     1260

gagatagccg atgcgctcga cggcgcgctc accgatgtga agtcgggtcg gcgccccgag     1320

tccgggttcg ccaaggccat gggatga                                         1347


<210>  95
<211>  448
<212>  PRT
<213>  Streptomyces alboniger

<400>  95

Val Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Lys Ala Leu Ser Arg Asp Asp Leu Leu Thr Glu Gly Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Asp Arg Leu Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Arg His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Thr Gln Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Gly Arg Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Ala 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Glu Gln Leu His Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ser Ala Leu Gly Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Arg Ala Phe Arg Ala Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Gly Lys Val Asn 
    370                 375                 380                 


Gln Leu Arg Met Thr Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Asp Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Gly Arg Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  96
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamX polypeptide

<400>  96

Val Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Met Lys Ala Val Thr Arg Asp Asp Leu Leu Thr Asp Gly Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Ile Trp Asn Val Ser Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Asp Ala Ile Lys Gln Gln Val Glu Arg Leu Pro Phe Ala Asn Thr Tyr 
65                  70                  75                  80  


Ala Phe Gly Arg Pro Ala Gln Val Thr Val Glu Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Arg His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Met Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Thr Gln Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Ile Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Gly Arg Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Ala 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Glu Asn Leu His Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ser Ala Leu Gly Arg Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Arg Ala Phe Arg Ala Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Thr Trp Thr Pro Gly Lys Val Asn 
    370                 375                 380                 


Gln Leu Arg Met Thr Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Ile 
385                 390                 395                 400 


Lys Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Leu Ala Asp Gly Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Ala Arg Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  97
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamX polypeptide

<400>  97

Val Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Val Arg Ala Leu Ser Arg Asp Asp Leu Ile Thr Glu Gly Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Asp Arg Leu Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Arg His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Ile Arg Gly Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Thr Gln Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Val Ile Thr Glu Phe Ala Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Gly Arg Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Ile Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Ala 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Met Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Val His Asp Arg 
        275                 280                 285             


Leu Tyr Glu Gln Leu His Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Leu Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Lys Glu Ala Asp Leu Leu Ser Gly Leu Gly Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Ile Arg Ala Phe Arg Ala Ile Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Asp Leu Gly Glu Pro Gly Gly Pro Thr Trp Ser Pro Ala Lys Val Asn 
    370                 375                 380                 


Asn Leu Arg Met Thr Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Leu Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Leu Ala Asp Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Ile Lys Ser Gly Lys Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  98
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamX polypeptide

<400>  98

Val Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Thr Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Met Lys Ala Leu Ser Arg Asp Asp Val Val Thr Glu Gly Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Ile Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Arg 
    50                  55                  60                  


Glu Ala Ile Arg Gln Gln Val Glu Lys Val Pro Phe Gly Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Glu Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Arg His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Ile Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Ala Leu Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Met Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Ser Gln Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Tyr Ala Pro Glu Arg Val Thr Ala Val Ile Leu 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Gly Lys Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Ala 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Glu Gln Leu His Glu Arg Thr Thr Gly Glu Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Leu Glu Asn Val Lys 
                325                 330                 335     


Arg Lys Glu Ala Asp Leu Leu Ser Ala Leu Gly Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Ile Arg Ala Phe Arg Ala Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Asp Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Gly Lys Val Asn 
    370                 375                 380                 


Gln Leu Arg Met Thr Leu Glu Ser Arg Gly Val Leu Thr Thr Ser Ile 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Ile Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Glu Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Thr Gly Arg Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  99
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamX polypeptide

<400>  99

Val Ile Asp Pro Ala Asp Tyr Ala Val Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Ile Arg Ala Leu Ser Arg Asp Asp Val Leu Thr Glu Gly Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Thr Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Asn Val Thr Leu Gly Tyr Ala Asn Thr Lys Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Glu Arg Ile Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Ile Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Ile Arg His Leu Pro Glu Gly Leu Asn His Val Lys Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Leu Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Ala Ala Gly Met Ile Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Leu Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Thr Gln Gly Ile Ser Asp Met Glu 
            180                 185                 190         


Arg Val Ile Thr Glu Tyr Gly Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Val Val Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Ala Lys Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Met Thr Gly Met Gly Arg Val Gly Asp Trp Thr Arg Ala 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Ser Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Leu Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu His Glu Arg Ser Ser Gly Glu Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Thr Thr Asn Asp Gly His Ala Val Gly Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Asp Asp Gly Val Val Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ser Gly Leu Gly Arg Met Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Arg Ala Phe Arg Ala Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Asp Pro Gly Gly Pro Ser Trp Ser Pro Ala Lys Met Asn 
    370                 375                 380                 


Gln Val Arg Met Thr Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Val 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Ile Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Asp Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Gly Arg Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  100
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamX polypeptide

<400>  100

Val Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Met Lys Ala Leu Ser Arg Asp Asp Leu Ile Thr Glu Gly Glu 
            20                  25                  30          


Gly Ile Arg Val Arg Asp Thr Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Gln Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Leu Asp Lys Leu Pro Phe Ala Asn Thr Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Arg His Leu Pro Asp Gly Leu Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Val Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Val Arg Ala Gly Gln Pro Glu Arg Leu Ala Val Phe Ala Leu Trp Asp 
    130                 135                 140                 


Ala Phe His Gly Gln Gly Pro Ala Ala Gly Met Leu Ser Gly Val Pro 
145                 150                 155                 160 


Tyr Ile His His Gln Thr Gly Pro Met Leu Pro Asp Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Ala Gly Ala Thr Asn Gly Val Ser Asp Met Glu 
            180                 185                 190         


Lys Leu Ile Ser Glu Phe Gly Pro Asp Arg Ile Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Ala Gly His Ile Leu Ser Pro Glu Tyr Leu 
    210                 215                 220                 


Gly Ser Leu Gly Arg Phe Cys Arg Gln His Asp Ile His Leu Ile Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Trp Thr Arg Ala 
                245                 250                 255     


Gly Gln Val Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Glu Gln Leu His Glu Arg Thr Ser Ala Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Gly Ala Ala Ala Ala Val 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Asp Glu Gly Leu Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Met Ser Ala Leu Gly Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Arg Ala Phe Arg Ala Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Ala Gly Pro Ser Trp Ser Pro Ala Arg Val Asn 
    370                 375                 380                 


Gln Leu Arg Met Thr Leu Glu Ser Arg Gly Val Leu Ser Thr Ser Ile 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Asp Ala Leu Asp Gly Ala Leu Thr Glu 
            420                 425                 430         


Val Lys Ser Ala Arg Arg Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  101
<211>  822
<212>  DNA
<213>  Streptomyces alboniger

<400>  101
gtgagtgacg acatgtccaa tgcgcacacc gatcgcaaga ccagcaagca gtggcaggaa       60

gaggcggcgg aggagtggga ccggtacgcc gacatctggg acagctggac ccccgatgac      120

agccgggacg atgccgagga ggccgcggac ttcctcgcgg gcctcgccaa gggcggcacc      180

gccctggagc tggggatcgg gacgggccgc gtagccctgc cgctcgcgca gcgcggcgtg      240

cgggtggccg gtatcgacgc ctcgccgaag atgctgctga agctcaagga gaagccgggc      300

ggggaccgga tcgaggtctt cgagggcaac ttcgccgatg tcgacgtcaa ggaggactac      360

gacgtcatct tcatcgccct cgccaccctg ttcgtcctgc ccgaccagga cgagcaggcc      420

cgctgcctgg ccaacagtgc caagcggctc aagccgggcg ggcggctcgt cgtccagaac      480

atcgtgccgg acatgacgta ctaccagcgc gggcggcaga acgactacgg gatgaccgag      540

ccgttccgta tctcgggccg gctggccggg cacccgcggc tcgcctggtt cgagatgaac      600

cacgtcgacc cgacgacgca gatggtcaag cgcacggacg tcatcatgag cgagaagggc      660

aaccgcatca tcgcggcgac catgcggttc gtgtggccct cggagcagga cctgatggcc      720

cggctgggcg gcctgacgct ggaggaccgc tggggaggct ggcgcaagga gcccttccac      780

tacgacagca gggacgcggt gtccgtctac cgcaagcagt ga                         822


<210>  102
<211>  273
<212>  PRT
<213>  Streptomyces alboniger

<400>  102

Val Ser Asp Asp Met Ser Asn Ala His Thr Asp Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Gly Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ala Gly Ile Asp Ala Ser Pro Lys Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Asp Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Asp Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Ser Glu Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Thr Leu Glu Asp Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  103
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamY polypeptide

<400>  103

Val Ser Asp Asp Met Ser Asn Ala His Thr Asp Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Gly Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Leu Ala Met Pro Leu Ala Asn Arg Gly Val 
65                  70                  75                  80  


Arg Val Ala Gly Ile Asp Ala Ser Pro Lys Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Asp Lys Pro Gly Gly Asp Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Lys Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Glu Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Lys Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Ile Ala Trp Phe Glu Met Asn His Val Glu Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Thr Glu Arg Gly Asn Arg Ile Ile 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Thr Val Glu Asp Arg Tyr Gly Gly Trp Arg Arg 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  104
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamY polypeptide

<400>  104

Val Ser Asp Asp Met Ser Asn Ala His Thr Glu Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Gly Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ala Gly Ile Asp Ala Ser Pro Lys Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Ala Gly Asp Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Asn Asp Glu Gln Ala Lys Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Asp Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Leu Ser Glu Pro Phe Arg Val Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Met Ala Trp Phe Glu Leu Asn His Val Asp Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Ser Glu Lys Gly Asn Arg Ile Val 
    210                 215                 220                 


Ala Ala Thr Met Arg Tyr Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Thr Val Glu Asp Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Tyr His Tyr Asp Ser Arg Asp Gly Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  105
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamY polypeptide

<400>  105

Val Ser Asp Asp Met Thr Asn Ala His Ser Asp Arg Lys Thr Ser Lys 
1               5                   10                  15      


Asn Trp Gln Glu Asp Ala Ala Glu Glu Trp Asp Arg Trp Ala Asp Val 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Glu Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Trp Leu Ala Gly Ile Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ala Gly Ile Asp Ala Ser Pro Arg Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Ala Ala Glu Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Asp Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Ser Asp Lys Gly Asn Arg Ile Leu 
    210                 215                 220                 


Ala Ala Ser Met Arg Tyr Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Thr Leu Glu Asp Arg Tyr Gly Gly Trp Lys Lys 
                245                 250                 255     


Asp Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  106
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamY polypeptide

<400>  106

Val Ser Asp Asp Met Thr Asn Ala His Thr Asp Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Phe Gln Glu Glu Ala Ala Glu Glu Trp Asp Lys Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Thr Arg Glu Asp Ala Glu Asp Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Gly Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Leu Ala Leu Pro Leu Ala Gln Lys Gly Leu 
65                  70                  75                  80  


Arg Val Ala Gly Ile Asp Ala Ser Pro Lys Met Leu Leu Arg Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Ala Asp Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Lys Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Met Val Pro Asp Leu Thr Tyr Tyr Gln Lys Gly Arg Gln Gln Glu Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Ile Ser Gly Arg Leu Gly Gly His Pro 
            180                 185                 190         


Arg Val Ala Trp Phe Glu Met Asn His Val Asp Pro Ser Thr Gln Met 
        195                 200                 205             


Val Arg Arg Thr Asp Val Ile Leu Ser Asp Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Gly Ala Ser Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Thr Val Glu Glu Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Glu Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  107
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamY polypeptide

<400>  107

Val Ser Asp Asp Met Ser Asn Ala His Thr Asp Arg Arg Ser Ser Lys 
1               5                   10                  15      


Gln Trp Asn Glu Glu Ala Gly Glu Glu Trp Asp Arg Phe Ala Glu Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Glu Ser Arg Glu Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Gly Leu Ala Lys Gly Ala Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Lys Val Ala Gly Ile Asp Ala Ser Pro Lys Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Asp Arg Ile Glu Val Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Lys Glu Asp Tyr Asp Val Ile Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Gly 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Leu Val Val Gln Asn 
145                 150                 155                 160 


Ile Leu Pro Glu Met Thr Tyr Tyr Gln Arg Gly Arg Gln Gln Asp Phe 
                165                 170                 175     


Gly Ile Thr Glu Pro Phe Arg Ile Ser Gly Lys Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Thr Gln Ile 
        195                 200                 205             


Leu Arg Arg Thr Asp Val Ile Leu Ser Glu Lys Gly Gln Arg Ile Ile 
    210                 215                 220                 


Ala Ala Ser Val Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Lys Leu Gly Gly Leu Thr Leu Glu Glu Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Tyr His Tyr Glu Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  108
<211>  807
<212>  DNA
<213>  Streptomyces alboniger

<400>  108
atgagcgaag agttcgggca ggatcgtccg gccgaagcgg gcagcgggag cggcacggac       60

gtgctcgtcg agcgccgcgg ccccgtgctc gtgatccaac tgaaccggcc gcgcgtacgc      120

aacgcgctga cccgcgccat ggccgaacgg ctcgccgccg ccttcacgga actggatgcc      180

cgagcggagc tgcgtctcgg cgtcctgacc ggcaccccgc cggcgttctg ctccggcatg      240

gacctcgggg ccttcgcccg cggggagcgc gcctccctgc cggggcgtgg cttcggcggt      300

ctgacggagc agccgccgag caagccgctg atcgccgccg tggagggtgc ggcggtcggc      360

ggtggtttcg agatggtgct cgcctgcgac atggtggtgg cggcggacga cgcggtgttc      420

gggctgcccg agctgcgccg agggctggtg gccgcggccg gcggactgct gcggctgccg      480

cgcgcgatcg cgccggccgt ggcgatggag atggcactga ccggcgaacc gatcgatgcg      540

cagcgggcct tcgcgctggg tcttgtcaac cgtgtggtgg ccccggggac ggcgctgacg      600

gccgcctgcg agctggcgga gaagatcgcc gcgcatgcgg accacgccgt cctcgcgagc      660

aagggggtcc tcgctcgggt gcgcgacggg gagttggcgg acgagtaccg gtcgcaccgc      720

gagctgctgt cggggatcct cgactccccc ggcgcgcggg caggtgcgcg tgagttcgtc      780

cgggaacgtc cgggcggacc gcgatga                                          807


<210>  109
<211>  268
<212>  PRT
<213>  Streptomyces alboniger

<400>  109

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Leu Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Gly Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Ala Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Leu Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ala Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Leu Thr Ala Ala Cys Glu Leu Ala Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Gly Val Leu 
    210                 215                 220                 


Ala Arg Val Arg Asp Gly Glu Leu Ala Asp Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Gly Ile Leu Asp Ser Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Glu Phe Val Arg Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  110
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamS polypeptide

<400>  110

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Leu Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Leu Glu Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Gly Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Ala Ala Phe Gly Arg Ala Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Ala Gly Ile Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Ala Asp Glu Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Ile Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ala Leu Gly Leu Val Asn Lys Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Leu Thr Ala Ala Cys Glu Leu Ala Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Gly Val Leu 
    210                 215                 220                 


Ala Arg Val Arg Asp Gly Glu Ile Ala Asp Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Glu Leu Ile Ser Gly Ile Leu Asp Ser Pro Gly Ala Lys Ala Gly Ala 
                245                 250                 255     


Arg Glu Phe Val Arg Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  111
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamS polypeptide

<400>  111

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Ala Ser Gly 
1               5                   10                  15      


Ser Gly Ser Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Val Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Met Pro Gly Arg 
                85                  90                  95      


Gly Phe Gly Gly Leu Thr Asp Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Ile Val Val Ala Ala Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Val Arg Arg Gly Leu Val Ala Gly Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ala Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Leu Thr Ala Ala Cys Glu Leu Ala Glu Arg 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Gly Val Leu 
    210                 215                 220                 


Ala Lys Val Arg Asp Gly Glu Leu Ala Asp Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Glu Leu Val Ser Gly Ile Leu Asp Ser Pro Gly Ala Lys Ala Gly Ala 
                245                 250                 255     


Lys Glu Phe Ile Arg Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  112
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamS polypeptide

<400>  112

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Gly Glu Ala Gly Ser Gly 
1               5                   10                  15      


Thr Ala Thr Asp Val Leu Leu Glu Arg Arg Gly Pro Val Leu Leu Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Ile Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Ala Ala Phe Ala Arg Ala Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Ala Phe Gly Ala Ile Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Ile Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Ala Asp Glu Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Ile Arg Arg Gly Leu Val Ala Ala Gly Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Val Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ala Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Leu Thr Ala Ala Cys Glu Leu Ala Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Gly Val Leu 
    210                 215                 220                 


Ala Arg Val Arg Asp Gly Glu Leu Ala Asp Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Gly Leu Leu Asp Ser Pro Gly Gly Arg Ala Gly Ala 
                245                 250                 255     


Arg Glu Phe Leu Arg Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  113
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamS polypeptide

<400>  113

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Gly Ala Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Asp Lys Arg Gly Pro Val Leu Ile Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Lys Val Arg Asn Ala Leu Thr Arg Gly Met Ala 
        35                  40                  45              


Asp Arg Leu Ala Ala Gly Phe Thr Glu Leu Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Ile 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Trp Gly Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Gly Glu Asp Ala Leu Phe Ala Leu Pro Glu 
    130                 135                 140                 


Leu Lys Arg Gly Leu Val Ala Ala Ala Gly Ala Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Glu Ala Asn Arg Ala Phe Ala Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Met Thr Ala Ala Cys Glu Ile Ala Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Ala Val Leu 
    210                 215                 220                 


Ala Arg Val Arg Asp Gly Asp Leu Ala Asp Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Asp Leu Leu Thr Gly Ile Leu Asp Ser Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Glu Phe Leu Lys Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  114
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamS polypeptide

<400>  114

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Asp Gly Gly Thr Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Lys Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Met Glu Ala Arg Ala Asp Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Lys Gly Glu Lys Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Tyr Gly Gly Met Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Gly Ala Leu Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Ala Glu Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Ile Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Val Val Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Gly Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ala Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Ala Pro Gly Thr Ala Met Thr Ala Ala Cys Glu Leu Ala Asp Arg 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Gly Ser Lys Gly Val Leu 
    210                 215                 220                 


Ala Arg Ile Arg Asp Gly Asp Leu Ala Glu Glu Tyr Arg Ser His Arg 
225                 230                 235                 240 


Glu Leu Val Ser Gly Val Leu Asp Ser Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Glu Phe Val Arg Glu Arg Pro Gly Gly Pro Arg 
            260                 265             


<210>  115
<211>  648
<212>  DNA
<213>  Streptomyces alboniger

<400>  115
atgcaagcgt taggtgtact cgtcgtcgat cgccaccccg tggtcaggta cgcgctgtcg       60

tcactgctcg acacgagagt ggcgtggacg gcggaggccg ccacgagtga cgaggcgtgg      120

aatgccgtca caacgtcctg cccgggtgtc gtcgtactcg aactggaact ggacggcgcg      180

accagcggtg ccgatctctg ccaacgggtg aaggcgatgg aggacgcgcc ccgggtcgtc      240

gtcttcaccg gagacacctc gcccggggcc gtcgtctccg ccatatcggc gggggccgac      300

agcttcctgc acaagagcgt gggcagttcg gaactcgtgg acgcggtggt gcgcacgtac      360

aacggccaac gcatgtggat acttggcaag aacgaacgcg aacacgtgga cgtgcgcagc      420

gtcatgcccg acgggctgcc cgccatcacc cgccgggaag agcaggtcct gagcctcgta      480

ctgcgccgct ataccaacga ggaaatcgcc agcgaactct ccctggcctc ccagaccata      540

aagaatcaag tcagtagcgc cctgcggaaa ctgggcgtca gcggccgacg tgaactgttc      600

cgtaagtact cctctccgac cggggtgacc accggggccc ggggttga                   648


<210>  116
<211>  215
<212>  PRT
<213>  Streptomyces alboniger

<400>  116

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Val Val Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Val Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Gly Ala Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Met Glu Asp Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Thr Ser Pro Gly Ala Val Val Ser Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ser Glu Leu 
            100                 105                 110         


Val Asp Ala Val Val Arg Thr Tyr Asn Gly Gln Arg Met Trp Ile Leu 
        115                 120                 125             


Gly Lys Asn Glu Arg Glu His Val Asp Val Arg Ser Val Met Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Leu Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  117
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamR1 polypeptide

<400>  117

Met Gln Ala Met Gly Val Leu Val Val Asp Arg His Pro Val Val Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Leu Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Gly Ala Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Val Glu Asp Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Thr Ser Pro Gly Ala Ile Val Ser Ala Leu Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ser Glu Leu 
            100                 105                 110         


Val Asp Ala Val Val Arg Thr Tyr Asn Gly Gln Arg Met Phe Ile Leu 
        115                 120                 125             


Gly Lys Asn Glu Arg Glu His Val Asp Val Arg Ser Val Leu Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Met Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Val Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Gln Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Arg Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  118
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamR1 polypeptide

<400>  118

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Val Val Arg 
1               5                   10                  15      


Tyr Gly Leu Ser Ser Met Leu Asp Thr Arg Val Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Ala Ala Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Met Glu Asp Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Ala Asp Thr Ser Pro Gly Ala Val Val Thr Ala Ile Ser 
                85                  90                  95      


Gly Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ser Glu Leu 
            100                 105                 110         


Val Asp Ala Val Val Arg Thr Tyr Asn Ala Gln Arg Met Tyr Ile Leu 
        115                 120                 125             


Gly Lys Asn Glu Arg Glu His Val Asp Val Arg Ser Val Met Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Lys Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Phe Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Leu Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Val Thr Thr Gly Gly Arg Gly 
    210                 215 


<210>  119
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamR1 polypeptide

<400>  119

Met Gln Ala Ile Gly Val Leu Val Val Asp Arg His Pro Val Leu Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Val Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Gly Thr Ser Asp Glu Ala Trp Asn Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Gly Ala Thr Ser Gly Ala 
    50                  55                  60                  


Glu Leu Cys Gln Arg Val Lys Ala Met Glu Asp Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Glu Ser Ser Pro Gly Ala Ile Leu Ser Ala Met Ser 
                85                  90                  95      


Gly Gly Ala Asp Ser Phe Leu His Lys Ser Ile Gly Ser Ser Glu Leu 
            100                 105                 110         


Val Asp Ala Val Val Arg Thr Tyr Asn Gly Gln Arg Met Trp Ile Leu 
        115                 120                 125             


Gly Lys Asn Glu Arg Asp His Val Asp Val Arg Ser Val Met Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Ile Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Asn Gln Val Ser Thr Ala Leu Lys Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Val Thr Thr Gly Gly Arg Gly 
    210                 215 


<210>  120
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamR1 polypeptide

<400>  120

Met Asn Ala Met Gly Val Leu Val Val Asp Arg His Pro Met Ile Arg 
1               5                   10                  15      


Tyr Gly Leu Ser Ser Met Leu Asp Thr Arg Ile Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Gly Thr Ser Asp Asp Ala Trp Gln Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Gly Gly Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Val Glu Asp Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Thr Ser Pro Ala Ala Val Leu Ser Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ser Glu Leu 
            100                 105                 110         


Val Asp Ala Val Val Arg Thr Tyr Asn Gly Gln Arg Met Trp Ile Val 
        115                 120                 125             


Gly Lys Asn Glu Arg Glu His Val Asp Met Arg Ser Val Met Pro Asp 
    130                 135                 140                 


Gly Leu Pro Gly Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Lys Arg Tyr Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Val Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Arg Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Leu Thr Thr Gly Gly Arg Gly 
    210                 215 


<210>  121
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamR1 polypeptide

<400>  121

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Leu Ile Arg 
1               5                   10                  15      


Phe Gly Leu Ser Thr Leu Leu Asp Thr Arg Ile Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Thr Thr Ser Cys Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Asp Gly Ala Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Lys Val Lys Ala Met Glu Asp Gly Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Thr Ser Pro Ala Ala Val Val Ser Ala Val Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Ile Gly Ser Ser Asp Leu 
            100                 105                 110         


Ile Glu Ala Val Val Arg Thr Tyr Asn Gly Gln Arg Leu Trp Val Leu 
        115                 120                 125             


Gly Lys Asn Glu Arg Glu His Leu Asp Val Lys Ser Val Leu Pro Asp 
    130                 135                 140                 


Gly Ile Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Ile Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Ser Glu Leu Ser Ile Ala 
                165                 170                 175     


Ser Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Pro Thr Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  122
<211>  984
<212>  DNA
<213>  Streptomyces alboniger

<400>  122
gtgaccgcat ccgctgagcc ggccgccccc gcgcaccgtg tcgtcgacgt ctgcgcgctg       60

tccctggacc gcgagtgctg gcggacgtac ttccgcgggc tcggcgcggt ggcgccggcg      120

tacctgcgcg ccttcggccg gcacgcgacc gcggtcttcg gcgccgatta cccgcgcttc      180

cgtgcccgcc tagacgccgg ggaccaggac ggtgccgtcg acctgctcgt gtcgggtcag      240

cccgaacgcg tcgactccga cgcgctgttg aagaccatgg acgacaacgg cgtcgtccac      300

cagatcctga tgagctgcgg cggcgccacc gccgacggcg acgacgtcaa cagccgggtc      360

gccgccgtcg ccgccaaggc gcccgaccgg ctccgggcct gggcgggcat tgacctgacc      420

gacccgggcc gtgccgtcgc cgagctggaa cgctgccatc ttctcggtat gcgcggcttc      480

gcggtgaccc cgttctggca gggcgtcgac ccgcgcgaca ccgcgtacga cccggtctac      540

cgcagggcac gagagctggg catgccgttg tggctgcaca ccgggcacca cttctcgcgg      600

cacgcggccg agttgtgcca tccccgcaac gtcgactgga tcgccctgcg tcaccccggc      660

ctgccgatcg tcgcggggca cgccgcctgg ccctggaccc ttgagctgat ctccatcgcc      720

cagcggcacc gccacgtcta cctcgacatc tcctcccacc gaccgcagtg gatggcccgc      780

cccggatcgg gctgggaatc cctgctcctg tacggcacca cggtgctgcg cgaccgggtc      840

ctgttcggct cggcgacctg ggtcaacgcc gatccggtcg ccgcgctcgc ccggcaggtc      900

gccgccctgg atctcggcga cgaggtcacg gacctctggc tgtacggcaa cgcggcccgc      960

ctgctcggac tcggccccgg ctga                                             984


<210>  123
<211>  327
<212>  PRT
<213>  Streptomyces alboniger

<400>  123

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Ala Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Asp Ala Gly Asp Gln Asp Gly Ala Val Asp Leu Leu Val Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Met Ser Cys Gly Gly Ala Thr Ala Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Arg Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Leu Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Val Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Trp Pro Trp Thr Leu Glu Leu Ile Ser Ile Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val Tyr Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Ala Arg Pro Gly Ser Gly Trp Glu Ser Leu Leu Leu Tyr Gly 
            260                 265                 270         


Thr Thr Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Ala Leu Ala Arg Gln Val Ala Ala Leu Asp 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Leu Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  124
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamH polypeptide

<400>  124

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Val Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Gly Pro Ala Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Asp Ala Gly Asp Gln Asp Gly Ala Val Asp Leu Leu Leu Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Ser Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Met Ser Cys Ala Gly Ala Thr Gly Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Arg Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Leu Ala Glu Leu Glu Arg Cys His Leu Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Leu Asp Trp Ile Ala Val Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Ala His Ala Ala Phe Pro Trp Thr Leu Glu Leu Met Ser Ile Ala 
225                 230                 235                 240 


Gln Arg His Lys His Val Tyr Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Ile Ala Arg Pro Gly Ser Gly Trp Glu Ser Leu Leu Leu Tyr Ala 
            260                 265                 270         


Thr Thr Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Tyr Leu 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Ala Leu Ala Arg Gln Val Ala Ala Leu Asp 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Leu Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  125
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamH polypeptide

<400>  125

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Val Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Ala Phe Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Asp Ala Gly Asp Gln Glu Gly Ala Val Asp Leu Leu Val Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Met Ser Cys Gly Gly Ala Thr Ala Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Arg Ala Pro 
        115                 120                 125             


Asp Arg Leu Arg Ala Trp Ala Gly Ile Glu Leu Thr Asp Pro Gly Lys 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Leu Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Glu Leu Gly Val Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Gly Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Val Glu Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Gly Ala Trp Pro Trp Thr Met Glu Leu Ile Ser Ile Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val Tyr Ile Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Ala Arg Pro Gly Ser Gly Phe Glu Ser Met Leu Leu Tyr Gly 
            260                 265                 270         


Thr Thr Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Tyr Val 
        275                 280                 285             


Asn Ala Asp Pro Leu Ala Ala Leu Ala Arg Gln Val Ala Ala Leu Asp 
    290                 295                 300                 


Leu Gly Asp Asp Val Thr Asp Leu Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  126
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamH polypeptide

<400>  126

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Ala Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Asp Ala Gly Asp Gln Asp Gly Ala Val Asp Leu Leu Ile Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Thr Met Asp Glu Asn 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Met Ser Cys Gly Gly Ala Thr Ala Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Leu Ala Ala Leu Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Arg Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Lys 
    130                 135                 140                 


Ala Ile Ala Glu Leu Glu Arg Cys His Leu Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Leu Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Asp Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Leu Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Gly Ala Trp Pro Tyr Thr Leu Asp Leu Ile Ser Leu Ala 
225                 230                 235                 240 


Gln Arg His Lys His Val Tyr Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Val Ala Arg Pro Gly Ser Ala Phe Glu Ser Val Leu Leu Tyr Gly 
            260                 265                 270         


Thr Thr Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Ile Ala Ala Leu Ala Arg Asn Leu Ala Gly Leu Asp 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Leu Trp Leu Phe Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  127
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamH polypeptide

<400>  127

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Leu Asp Arg Asp Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Gly Pro Ala Phe Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Gly Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Asp Ala Gly Asp Gln Glu Gly Ala Val Asp Leu Leu Val Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Met Thr Cys Gly Ala Gly Thr Ala Asp 
            100                 105                 110         


Gly Glu Asp Leu Asn Ser Arg Val Ala Ala Val Ala Ala Arg Ala Pro 
        115                 120                 125             


Glu Arg Leu Arg Ala Phe Ala Gly Ile Asp Leu Thr Glu Pro Gly Lys 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Leu Leu Gly Met Lys Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Phe Asn Ala Val Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Tyr Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Gln Val Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Ala His Gly Ala Trp Pro Tyr Thr Leu Glu Met Leu Ser Ile Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val Tyr Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Tyr Ile Ala Arg Pro Ala Ser Gly Tyr Glu Ser Leu Leu Leu Tyr Gly 
            260                 265                 270         


Thr Thr Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Phe Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Ala Leu Ala Arg Gln Val Ala Ala Leu Asp 
    290                 295                 300                 


Leu Gly Glu Glu Leu Thr Asp Leu Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  128
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamH polypeptide

<400>  128

Val Thr Ala Ser Ala Glu Pro Ala Ala Pro Ala His Arg Val Val Asp 
1               5                   10                  15      


Val Cys Ala Leu Ser Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Ala Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Pro Arg Phe Arg Ala Lys Leu 
    50                  55                  60                  


Asp Ala Ala Asp Gln Asp Gly Ala Val Asp Leu Leu Val Ser Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Ser Asp Ala Leu Leu Lys Thr Met Asp Glu Gln 
                85                  90                  95      


Gly Val Val His Gln Ile Leu Leu Ser Cys Gly Gly Ala Thr Ala Asp 
            100                 105                 110         


Ala Asp Asp Val Asn Ser Arg Val Ala Ala Leu Ala Ala Lys Ala Pro 
        115                 120                 125             


Glu Arg Leu Arg Ala Phe Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Ile Ala Glu Leu Asp Arg Cys His Leu Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Tyr Asn Gly Ile Asp Pro Arg Asp Thr Ala Tyr 
                165                 170                 175     


Asp Pro Val Tyr Arg Arg Ala Arg Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Ser Gly His His Phe Ser Lys His Gly Ala Asp Leu Cys His Pro 
        195                 200                 205             


Arg Gln Val Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Gly Ala Phe Pro Trp Thr Ile Asp Leu Leu Ser Ile Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val Tyr Leu Asp Ile Ser Ser His Arg Pro Asn 
                245                 250                 255     


Phe Met Ala Arg Pro Ala Ser Gly Trp Glu Ser Leu Leu Leu Tyr Gly 
            260                 265                 270         


Thr Ser Val Leu Arg Asp Arg Val Leu Phe Gly Ser Ala Thr Trp Met 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Ala Leu Ala Arg Asn Leu Ala Gly Leu Asp 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Leu Trp Leu Tyr Ala Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  129
<211>  738
<212>  DNA
<213>  Streptomyces alboniger

<400>  129
gtgaatgaaa cttctggacg agaaaacaca ccgaaaggcc aacccggctc gatctggctg       60

cgcgaggtga agcagcggcc ggcgaggcag ccgctgagcc gtgaacagat cgtgcaggcg      120

gcggtgcgtc tcctggatga ggggggtgtc cgcaacctgc gcatgcgtca gctcgcggac      180

tcgctgaact cggcaccgat gtcgttgtac tggcacgtgt cgaccaagga cgacctgctg      240

gaactggcca tcgacgcggt gttccccgac ccgccttccc ggtccggcac gggggactgg      300

cgcgacgaca tcaaggcggg cgcgacggat ttgttcgagg tactgctgcg gcactcctgg      360

atgatcgagc tgatgggcgg tcaccccccg gtggggcccc gcgcgctggc gcacaccagc      420

gccatcatcg agatcctgga gcaggcccac ttctccccga ggcagctgga ctcagcgctc      480

tcggcgatct actactacac cgtgggcgcc gccttgtccg aggcgtcctg gcaggcgatg      540

gcgcgccaga gcgccgagag cgaggaggag tgggtgagtc gcctcggccc ctacctcggc      600

atggcgaccc agtcccaccc ggcttccctg gccgactacg tcaagcgcag cgcttcgagc      660

agcacgggcc agcgattcca cgacggcctc gaatgcatgg tgtccggcat ggggcagatg      720

cgttcccagg actcctga                                                    738


<210>  130
<211>  245
<212>  PRT
<213>  Streptomyces alboniger

<400>  130

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Lys Gly Gln Pro Gly 
1               5                   10                  15      


Ser Ile Trp Leu Arg Glu Val Lys Gln Arg Pro Ala Arg Gln Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Val Arg Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Ile Asp Ala Val Phe Pro Asp Pro Pro Ser Arg Ser Gly 
                85                  90                  95      


Thr Gly Asp Trp Arg Asp Asp Ile Lys Ala Gly Ala Thr Asp Leu Phe 
            100                 105                 110         


Glu Val Leu Leu Arg His Ser Trp Met Ile Glu Leu Met Gly Gly His 
        115                 120                 125             


Pro Pro Val Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Ile Glu 
    130                 135                 140                 


Ile Leu Glu Gln Ala His Phe Ser Pro Arg Gln Leu Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Ala Ile Tyr Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Ala Ser 
                165                 170                 175     


Trp Gln Ala Met Ala Arg Gln Ser Ala Glu Ser Glu Glu Glu Trp Val 
            180                 185                 190         


Ser Arg Leu Gly Pro Tyr Leu Gly Met Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Ala Asp Tyr Val Lys Arg Ser Ala Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Asp Gly Leu Glu Cys Met Val Ser Gly Met Gly Gln Met 
225                 230                 235                 240 


Arg Ser Gln Asp Ser 
                245 


<210>  131
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamR2 polypeptide

<400>  131

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Lys Gly Gln Pro Gly 
1               5                   10                  15      


Ser Ile Trp Leu Arg Glu Val Lys Gln Arg Pro Ala Arg Gln Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Val Arg Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Ile Asp Ala Met Phe Pro Asp Pro Pro Ser Arg Ser Gly 
                85                  90                  95      


Thr Gly Asp Trp Arg Asp Asp Ile Arg Ala Gly Ala Thr Asp Leu Phe 
            100                 105                 110         


Glu Val Leu Leu Arg His Ser Trp Met Ile Glu Leu Leu Gly Gly His 
        115                 120                 125             


Pro Pro Val Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Leu Glu 
    130                 135                 140                 


Ile Leu Glu Gln Ala His Phe Ser Pro Arg Gln Leu Asp Ser Ala Val 
145                 150                 155                 160 


Ser Ala Ile Tyr Tyr Phe Thr Val Gly Ala Ala Leu Ser Glu Ala Ser 
                165                 170                 175     


Trp Gln Ala Leu Ala Arg Gln Ser Ala Asp Thr Glu Glu Glu Trp Val 
            180                 185                 190         


Ser Arg Leu Gly Pro Tyr Leu Gly Met Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Ala Asp Tyr Val Lys Arg Ser Gly Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Asp Gly Leu Glu Cys Met Val Ser Gly Met Ala Gln Leu 
225                 230                 235                 240 


Arg Thr Gln Asp Ser 
                245 


<210>  132
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamR2 polypeptide

<400>  132

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Lys Gly Gln Pro Gly 
1               5                   10                  15      


Ser Ile Trp Leu Arg Glu Val Lys Gln Arg Pro Gly Arg Gln Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Val Arg Asn Leu Arg Met Arg Gln Leu Ala Glu Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Ile Asp Ala Val Phe Pro Asp Pro Pro Ser Arg Thr Gly 
                85                  90                  95      


Thr Gly Asp Trp Arg Asp Asp Ile Lys Ala Gly Ala Thr Asp Leu Phe 
            100                 105                 110         


Glu Leu Leu Leu Arg His Ser Trp Met Leu Glu Leu Met Ala Gly His 
        115                 120                 125             


Pro Pro Val Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Ile Glu 
    130                 135                 140                 


Leu Leu Glu Gln Ala His Phe Ser Pro Arg Gln Leu Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Gly Ile Trp Tyr Tyr Thr Val Gly Ala Ala Val Ser Glu Ala Ser 
                165                 170                 175     


Trp Gln Ala Met Ala Arg Gln Ser Ala Glu Thr Glu Glu Glu Trp Val 
            180                 185                 190         


Ser Arg Leu Ala Pro Tyr Leu Gly Met Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Ala Asp Tyr Val Lys Arg Thr Ala Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Asp Gly Leu Glu Cys Met Val Ser Gly Met Gly Gln Met 
225                 230                 235                 240 


Arg Ser Gln Asp Ser 
                245 


<210>  133
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamR2 polypeptide

<400>  133

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Arg Gly Gln Pro Gly 
1               5                   10                  15      


Ser Ile Trp Leu Arg Glu Val Lys Gln Arg Pro Ala Arg Gln Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Val Arg Asn Leu Arg Met Arg Asn Leu Ala Asp Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Ile Asp Ala Val Phe Pro Asp Pro Pro Ser Arg Ser Gly 
                85                  90                  95      


Thr Gly Asp Trp Lys Asp Asp Ile Arg Ala Gly Ala Thr Asp Leu Phe 
            100                 105                 110         


Glu Val Leu Val Arg His Ser Trp Leu Val Glu Leu Met Gly Gly His 
        115                 120                 125             


Pro Pro Val Gly Pro Arg Ala Leu Ala His Thr Ser Ala Val Ile Glu 
    130                 135                 140                 


Ile Leu Glu Gln Ala His Phe Ser Pro Arg Gln Leu Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Ala Ile Trp Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Gly Ser 
                165                 170                 175     


Trp Gln Ala Met Ala Arg Gln Thr Ala Glu Ser Glu Asp Glu Phe Val 
            180                 185                 190         


Ser Arg Val Ala Pro Tyr Leu Gly Met Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Ala Asp Tyr Val Lys Arg Thr Ala Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Asp Gly Leu Glu Cys Met Val Ser Gly Met Gly Gln Leu 
225                 230                 235                 240 


Arg Thr Gln Asp Ser 
                245 


<210>  134
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamR2 polypeptide

<400>  134

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Lys Ala Gln Pro Ala 
1               5                   10                  15      


Ser Ile Trp Ile Arg Glu Val Lys Gln Arg Pro Ala Arg Asn Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Leu Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Val Arg Asn Leu Arg Met Arg Gln Leu Ala Glu Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Ile Asp Ala Val Phe Pro Asp Pro Pro Thr Arg Thr Gly 
                85                  90                  95      


Thr Gly Asp Trp Arg Asp Asp Ile Lys Ala Gly Ala Thr Asp Leu Phe 
            100                 105                 110         


Glu Val Leu Leu Arg His Ser Trp Met Leu Glu Leu Met Gly Gly His 
        115                 120                 125             


Pro Pro Leu Gly Pro Arg Ala Met Ala His Thr Ser Ala Ile Val Glu 
    130                 135                 140                 


Leu Leu Glu Gln Ala His Phe Ser Pro Arg Gln Leu Glu Ser Ala Met 
145                 150                 155                 160 


Ser Ala Ile Tyr Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Ala Ser 
                165                 170                 175     


Trp Gln Gly Met Ala Arg Gln Ser Ala Asp Ser Glu Glu Glu Tyr Val 
            180                 185                 190         


Ser Arg Met Gly Pro Tyr Met Gly Val Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Gly Asp Tyr Val Lys Arg Ser Gly Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Asp Gly Leu Glu Cys Met Val Ser Gly Met Ala Gln Leu 
225                 230                 235                 240 


Arg Ser Gln Asp Ser 
                245 


<210>  135
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamR2 polypeptide

<400>  135

Val Asn Glu Thr Ser Gly Arg Glu Asn Thr Pro Lys Ala Gln Pro Gly 
1               5                   10                  15      


Ser Ile Trp Leu Arg Glu Val Lys Gln Arg Pro Ala Arg Gln Pro Leu 
            20                  25                  30          


Ser Arg Glu Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly 
        35                  40                  45              


Gly Leu Arg Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Asn Ser 
    50                  55                  60                  


Ala Pro Met Ser Leu Tyr Trp His Val Ser Thr Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Glu Leu Ala Val Asp Ala Val Tyr Pro Glu Pro Pro Ser Arg Ser Gly 
                85                  90                  95      


Thr Gly Asp Trp Arg Glu Asp Ile Lys Ala Gly Ala Ser Glu Val Phe 
            100                 105                 110         


Asp Val Met Leu Arg His Ser Trp Leu Ile Glu Leu Leu Gly Gly His 
        115                 120                 125             


Pro Pro Leu Gly Pro Arg Ala Leu Ala His Thr Ser Ala Leu Ile Glu 
    130                 135                 140                 


Leu Leu Glu Gln Gly His Phe Ser Pro Arg Gln Leu Asp Ser Ala Val 
145                 150                 155                 160 


Thr Gly Ile Tyr Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Ala Ser 
                165                 170                 175     


Trp Gln Ala Met Ala Lys Gln Ser Ala Glu Thr Glu Glu Glu Trp Val 
            180                 185                 190         


Ser Arg Leu Gly Pro Phe Leu Gly Met Ala Thr Gln Ser His Pro Ala 
        195                 200                 205             


Ser Leu Ala Asp Tyr Val Lys Arg Ser Ala Ser Ser Ser Thr Gly Gln 
    210                 215                 220                 


Arg Phe His Glu Gly Leu Glu Cys Met Val Ser Gly Met Gly Gln Leu 
225                 230                 235                 240 


Arg Ser Gln Asp Ser 
                245 


<210>  136
<211>  1677
<212>  DNA
<213>  Streptomyces alboniger

<400>  136
atggacggcg tggtgcatga gcagcagggc gcgggccgcg gaggaggtga gggcggtgac       60

gacggcggcg tccccggggc gaaaaaccga tgggcggtac tgggcgtcct ctcgctgagc      120

cttctcgtcg tcgccctcga cctgacggtg ctgaacgtgg ccctgcccac gctcagcacc      180

gaacttcgac cctcgtcggt gcagttgctg tggatcgtcg acgtctactc gctcgtcgtc      240

gccggcctgc tcatcagctg cggcacgctc ggcgaccgcc tgggccgcaa acgtttcctg      300

tgccttggct tcatcgtctt cggcggcgca tcggccgccg cggcctgggc gagcgggccc      360

gcgatgctga tcacggcccg cgcgctgctc ggaatcggcg ccgcgatcat catgccgtcg      420

acgctctcga tcatccggaa cgtgttcacc gaccgcaagg agcggacggt ggcgctcgcc      480

gtgtgggcca ccatgtccgc ggccggtgcc gcggtcgggc cggtggtcgg cggtgtcatg      540

atcgagcact tctggtgggg ctcggtcttc ctgatcaacg tgcccatcat ggtcctcgcc      600

cttatcgccg cgctgaccct ggtgccggag tcccggcatc cgaatccgcc gcgctgggac      660

accgccggag ccctgctgtc cgtcaccggt ctgatctccc tcgtgtacgc gattcagcac      720

ggcggcgcga agggcctgga ggcgcagacg atcatcacag gcgtgctcgg cctggtgctg      780

ctcaccgccc tggtggtgcg agtgctgcgc atccgcgatc cgctcttcga cccgaccctc      840

ttccgcgacc gcgcgttctc cgtggcggtg gtgtccgtgg tcctcgccat gttcggcatg      900

ggcgggctga tgctgctgct cacgcagcac tggcagttca tcggcggcgc ctcgccgatg      960

gagtcgggcc ttcagctgct gccgttgctc ctggccacca tgatcggggc cccgatcatg     1020

tccgtcatcg tcccgaggta cgggacgcgg tacgccatga tgatcggcat gggcctgatc     1080

ggcgccgcgt tcttcgtcct gatgaacgtc gagcccgaca ccgagtactg ggtcttcgcc     1140

atcgccctcg cgggcatcgg cgccggcgcg ggttgcgcca tgacggccgc gtcggacgcc     1200

atcatgtcga cggccgacgc ggataccgcg ggtggcgccg cgggcatcga ggagacctcc     1260

tacgaactcg gcaacggact gagcgtggcg atcatgggca gcgtggcgtc cgcgctcttc     1320

cgcagggaga tggacgaccc cgtcgccggg gtggacccca aggccatgga tgccgcgcgc     1380

gaaggcctcc ccgacgccgt cggagtggcc ggtgccctgc ccggtgccgt cggggaggag     1440

ttgaagcggc gagccgacaa cgcgttcacg gacgcgttcg gggtcacgtc gctgtgcacc     1500

ggcgtcatcc tcgtggtggt ggcggtcgcc gtcttcctgt tcatcccgcc ctcggcgggg     1560

cggatcaccc cggcgaccga gggcggcggt gacgcgcccg aggacggcgt ggatctggtg     1620

aaacaggaat cgagggagtc cgccgacggc cgcccaacgc ccgtggaccg gccctga        1677


<210>  137
<211>  558
<212>  PRT
<213>  Streptomyces alboniger

<400>  137

Met Asp Gly Val Val His Glu Gln Gln Gly Ala Gly Arg Gly Gly Gly 
1               5                   10                  15      


Glu Gly Gly Asp Asp Gly Gly Val Pro Gly Ala Lys Asn Arg Trp Ala 
            20                  25                  30          


Val Leu Gly Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
        35                  40                  45              


Thr Val Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Arg Pro 
    50                  55                  60                  


Ser Ser Val Gln Leu Leu Trp Ile Val Asp Val Tyr Ser Leu Val Val 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Leu Gly Phe Ile Val Phe Gly Gly Ala Ser Ala 
            100                 105                 110         


Ala Ala Ala Trp Ala Ser Gly Pro Ala Met Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
    130                 135                 140                 


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Leu Ala 
145                 150                 155                 160 


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
                165                 170                 175     


Gly Gly Val Met Ile Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Met Val Leu Ala Leu Ile Ala Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Leu Leu Ser Val Thr Gly Leu Ile Ser Leu Val Tyr Ala Ile Gln His 
225                 230                 235                 240 


Gly Gly Ala Lys Gly Leu Glu Ala Gln Thr Ile Ile Thr Gly Val Leu 
                245                 250                 255     


Gly Leu Val Leu Leu Thr Ala Leu Val Val Arg Val Leu Arg Ile Arg 
            260                 265                 270         


Asp Pro Leu Phe Asp Pro Thr Leu Phe Arg Asp Arg Ala Phe Ser Val 
        275                 280                 285             


Ala Val Val Ser Val Val Leu Ala Met Phe Gly Met Gly Gly Leu Met 
    290                 295                 300                 


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Met 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Met Ser Val Ile Val Pro Arg Tyr Gly Thr Arg Tyr Ala 
            340                 345                 350         


Met Met Ile Gly Met Gly Leu Ile Gly Ala Ala Phe Phe Val Leu Met 
        355                 360                 365             


Asn Val Glu Pro Asp Thr Glu Tyr Trp Val Phe Ala Ile Ala Leu Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Ile Met Ser Thr Ala Asp Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
                405                 410                 415     


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
            420                 425                 430         


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Met Asp Asp Pro Val 
        435                 440                 445             


Ala Gly Val Asp Pro Lys Ala Met Asp Ala Ala Arg Glu Gly Leu Pro 
    450                 455                 460                 


Asp Ala Val Gly Val Ala Gly Ala Leu Pro Gly Ala Val Gly Glu Glu 
465                 470                 475                 480 


Leu Lys Arg Arg Ala Asp Asn Ala Phe Thr Asp Ala Phe Gly Val Thr 
                485                 490                 495     


Ser Leu Cys Thr Gly Val Ile Leu Val Val Val Ala Val Ala Val Phe 
            500                 505                 510         


Leu Phe Ile Pro Pro Ser Ala Gly Arg Ile Thr Pro Ala Thr Glu Gly 
        515                 520                 525             


Gly Gly Asp Ala Pro Glu Asp Gly Val Asp Leu Val Lys Gln Glu Ser 
    530                 535                 540                 


Arg Glu Ser Ala Asp Gly Arg Pro Thr Pro Val Asp Arg Pro 
545                 550                 555             


<210>  138
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of pamW polypeptide

<400>  138

Met Asp Gly Val Val His Glu Gln Gln Gly Ala Gly Arg Ala Gly Gly 
1               5                   10                  15      


Glu Gly Gly Asp Asp Ala Gly Val Pro Gly Ala Lys Asn Arg Trp Ala 
            20                  25                  30          


Val Leu Gly Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Ile 
        35                  40                  45              


Thr Val Leu Asn Val Ala Leu Pro Ser Leu Ser Thr Glu Leu Arg Pro 
    50                  55                  60                  


Ser Ser Val Gln Leu Leu Trp Ile Val Asp Val Tyr Thr Leu Val Val 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Leu Gly Phe Ile Val Phe Gly Gly Ala Ser Ala 
            100                 105                 110         


Ala Ala Ala Phe Ala Ser Gly Pro Ala Leu Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Met Thr Met 
    130                 135                 140                 


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Leu Ala 
145                 150                 155                 160 


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
                165                 170                 175     


Gly Gly Val Met Ile Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Met Val Leu Ala Leu Ile Ala Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Ile Leu Ser Val Thr Gly Leu Ile Ser Leu Val Tyr Gly Ile Gln His 
225                 230                 235                 240 


Gly Gly Ala Arg Gly Leu Glu Ala Gln Thr Ile Leu Ser Gly Val Leu 
                245                 250                 255     


Gly Ile Val Leu Leu Thr Ala Leu Val Val Arg Val Leu Arg Ile Arg 
            260                 265                 270         


Asp Pro Leu Phe Asp Pro Thr Leu Phe Arg Asp Arg Ala Phe Ser Val 
        275                 280                 285             


Ala Leu Val Ser Val Val Leu Ala Met Phe Gly Met Gly Gly Leu Met 
    290                 295                 300                 


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Val 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Leu Leu Pro Leu Leu Leu Ala Ser Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Met Ser Val Ile Val Pro Arg Tyr Gly Thr Arg Tyr Ala 
            340                 345                 350         


Met Met Ile Gly Met Gly Leu Ile Gly Ala Ala Phe Phe Val Leu Met 
        355                 360                 365             


Asn Leu Glu Pro Asp Thr Glu Tyr Trp Val Phe Ala Ile Ala Ile Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Ile Leu Ser Thr Ala Asp Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
                405                 410                 415     


Glu Glu Thr Thr Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
            420                 425                 430         


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Met Asp Asp Pro Val 
        435                 440                 445             


Ala Gly Val Asp Pro Lys Ala Ile Asp Ala Ala Arg Glu Gly Leu Pro 
    450                 455                 460                 


Asp Ala Val Gly Val Ala Ala Ala Leu Pro Gly Ala Val Gly Glu Glu 
465                 470                 475                 480 


Leu Lys Arg Arg Ala Asp Asn Ala Tyr Thr Asp Ala Phe Gly Val Thr 
                485                 490                 495     


Ser Ile Cys Thr Gly Val Ile Leu Val Val Val Ala Val Ala Leu Phe 
            500                 505                 510         


Leu Phe Ile Pro Pro Ser Ala Gly Arg Ile Thr Pro Ala Thr Glu Gly 
        515                 520                 525             


Gly Gly Asp Ala Pro Glu Asp Gly Val Asp Leu Val Lys Gln Glu Ser 
    530                 535                 540                 


Arg Glu Ser Ala Asp Gly Arg Pro Thr Pro Val Asp Arg Pro 
545                 550                 555             


<210>  139
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of pamW polypeptide

<400>  139

Met Asp Gly Val Val His Glu Gln Gln Gly Ala Gly Arg Gly Gly Gly 
1               5                   10                  15      


Glu Gly Gly Asp Asp Gly Gly Val Pro Gly Ala Lys Asn Arg Trp Ala 
            20                  25                  30          


Val Leu Gly Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
        35                  40                  45              


Thr Val Leu Asn Val Ala Leu Pro Thr Leu Thr Thr Asp Leu Arg Pro 
    50                  55                  60                  


Ser Ser Val Gln Ile Leu Trp Ile Leu Asp Val Tyr Ser Leu Val Val 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Leu Gly Phe Ile Val Phe Gly Gly Ala Ser Ala 
            100                 105                 110         


Ala Ala Ala Trp Ala Thr Gly Pro Ala Met Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
    130                 135                 140                 


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Met Ala 
145                 150                 155                 160 


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
                165                 170                 175     


Gly Gly Val Met Ile Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Leu Val Leu Ala Leu Ile Ala Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Leu Leu Ser Val Thr Gly Leu Ile Ser Leu Val Tyr Ala Ile Gln His 
225                 230                 235                 240 


Gly Gly Ala Lys Ala Leu Asp Ala Gln Thr Ile Ile Thr Gly Val Leu 
                245                 250                 255     


Gly Leu Val Met Leu Thr Ala Leu Val Val Arg Val Leu Lys Leu Arg 
            260                 265                 270         


Asp Pro Leu Phe Asp Pro Ser Leu Phe Arg Asp Arg Ala Phe Ser Val 
        275                 280                 285             


Ala Val Val Ser Val Val Leu Ala Met Phe Gly Met Gly Gly Leu Ile 
    290                 295                 300                 


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Met 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Val Ser Val Ile Val Pro Arg Tyr Gly Thr Arg Tyr Ala 
            340                 345                 350         


Met Met Ile Gly Leu Gly Leu Ile Gly Ala Ala Phe Phe Val Leu Met 
        355                 360                 365             


Asn Val Asp Pro Asp Thr Glu Tyr Trp Leu Phe Ala Ile Ala Leu Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Gly Met Thr Ala Gly Ser Asp Ala 
385                 390                 395                 400 


Ile Leu Ser Thr Ala Asp Ala Asp Thr Ala Gly Ala Ala Ala Gly Ile 
                405                 410                 415     


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
            420                 425                 430         


Gly Ser Val Ala Ser Ala Leu Tyr Arg Arg Glu Leu Asp Asp Pro Val 
        435                 440                 445             


Ala Gly Val Asp Pro Lys Ala Met Asp Ala Ala Arg Glu Gly Leu Pro 
    450                 455                 460                 


Asp Ala Val Gly Val Ala Gly Ala Leu Pro Gly Ala Val Gly Asp Glu 
465                 470                 475                 480 


Val Lys Arg Arg Ala Asp Asn Ala Phe Thr Asp Ala Phe Gly Val Thr 
                485                 490                 495     


Ser Leu Cys Thr Gly Val Ile Met Val Val Val Ala Val Ala Val Phe 
            500                 505                 510         


Leu Phe Ile Pro Pro Ser Ala Gly Arg Ile Thr Pro Ala Thr Glu Gly 
        515                 520                 525             


Gly Gly Asp Ala Pro Glu Asp Gly Val Asp Leu Val Lys Gln Glu Ser 
    530                 535                 540                 


Arg Glu Ser Ala Asp Ala Arg Pro Thr Pro Val Asp Arg Pro 
545                 550                 555             


<210>  140
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of pamW polypeptide

<400>  140

Met Asp Gly Val Val His Asp Gln Gln Gly Ala Gly Arg Gly Gly Gly 
1               5                   10                  15      


Glu Gly Gly Asp Asp Gly Gly Val Pro Gly Ala Lys Asn Arg Trp Ala 
            20                  25                  30          


Val Leu Gly Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
        35                  40                  45              


Ser Met Val Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Arg Pro 
    50                  55                  60                  


Ser Ser Val Gln Leu Leu Tyr Ile Ile Asp Val Tyr Thr Leu Val Val 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Ile Gly Phe Ile Val Phe Gly Gly Ala Thr Ala 
            100                 105                 110         


Ala Ala Ala Trp Ala Ser Gly Pro Ala Met Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Leu Gly Ile Gly Gly Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
    130                 135                 140                 


Ile Arg Asn Val Phe Thr Asp Lys Lys Glu Arg Thr Val Ala Leu Ala 
145                 150                 155                 160 


Leu Phe Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Leu Val 
                165                 170                 175     


Gly Gly Val Met Ile Glu His Tyr Trp Trp Gly Thr Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Met Val Leu Ala Leu Ile Ala Ala Leu Thr Met Val 
        195                 200                 205             


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Ile Leu Ser Val Thr Gly Val Ile Ser Leu Val Tyr Ala Ile Gln His 
225                 230                 235                 240 


Gly Gly Ala Lys Gly Leu Glu Ala Gln Thr Leu Ile Thr Gly Val Leu 
                245                 250                 255     


Gly Leu Val Leu Leu Thr Ala Leu Val Val Arg Val Leu Arg Ile Arg 
            260                 265                 270         


Asp Pro Leu Phe Glu Pro Thr Leu Phe Arg Asp Arg Ala Phe Ser Val 
        275                 280                 285             


Ala Val Val Ser Val Val Leu Ala Met Phe Ala Met Gly Gly Met Met 
    290                 295                 300                 


Leu Val Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Met 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Met Leu Pro Leu Met Leu Ala Thr Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Met Ser Val Ile Val Pro Arg Tyr Gly Thr Arg Tyr Ala 
            340                 345                 350         


Met Met Val Gly Ile Gly Leu Val Gly Ala Ala Phe Phe Val Leu Met 
        355                 360                 365             


Asn Val Glu Pro Asp Thr Glu Trp Trp Val Phe Ala Ile Ala Ile Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Ile Met Ser Thr Ala Asp Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
                405                 410                 415     


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Val 
            420                 425                 430         


Gly Ser Val Ala Ser Ala Leu Trp Arg Arg Glu Met Asp Asp Pro Val 
        435                 440                 445             


Ala Gly Val Asp Pro Lys Ala Met Asp Ala Ala Arg Glu Gly Leu Pro 
    450                 455                 460                 


Asp Gly Val Gly Val Ala Gly Ala Leu Pro Gly Ala Ile Ala Glu Glu 
465                 470                 475                 480 


Leu Lys Arg Arg Ala Asp Asn Ala Tyr Thr Asp Ala Phe Gly Val Thr 
                485                 490                 495     


Ser Leu Cys Thr Gly Val Ile Leu Val Val Val Ala Val Ala Val Phe 
            500                 505                 510         


Leu Phe Leu Pro Pro Ser Ala Gly Lys Ile Thr Pro Ala Thr Glu Gly 
        515                 520                 525             


Gly Gly Asp Ala Pro Asp Asp Gly Val Asp Leu Val Lys Gln Glu Ser 
    530                 535                 540                 


Arg Glu Ser Ala Asp Gly Arg Pro Thr Pro Val Asp Arg Pro 
545                 550                 555             


<210>  141
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of pamW polypeptide

<400>  141

Met Asp Gly Ile Val His Glu Gln Gln Gly Gly Gly Arg Gly Gly Gly 
1               5                   10                  15      


Glu Ala Ala Asp Asp Gly Gly Val Pro Gly Ala Arg Asn Arg Trp Ala 
            20                  25                  30          


Ile Leu Ala Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
        35                  40                  45              


Thr Met Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Arg Pro 
    50                  55                  60                  


Ser Thr Val Gln Leu Leu Trp Ile Val Asp Val Tyr Ser Leu Val Val 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Leu Gly Phe Ile Val Phe Gly Gly Ala Ser Ala 
            100                 105                 110         


Ala Ala Ala Phe Ala Ser Gly Pro Ala Met Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Ile Gly Ile Gly Ala Ala Ile Ile Leu Pro Ser Thr Leu Thr Ile 
    130                 135                 140                 


Ile Arg Asn Leu Trp Thr Asp Arg Lys Glu Arg Thr Leu Ala Val Ala 
145                 150                 155                 160 


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
                165                 170                 175     


Gly Gly Met Met Leu Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Met Val Leu Ala Leu Ile Ala Ala Met Thr Leu Leu 
        195                 200                 205             


Pro Glu Ser Arg His Pro Asn Pro Pro Lys Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Leu Leu Ser Val Thr Ala Leu Ile Ser Leu Ile Tyr Ala Ile Gln His 
225                 230                 235                 240 


Gly Ala Ala Lys Gly Leu Glu Ala Gln Thr Ile Val Thr Gly Val Leu 
                245                 250                 255     


Gly Ile Val Leu Ile Thr Ala Val Ile Leu Arg Val Leu Arg Ile Arg 
            260                 265                 270         


Asp Pro Leu Phe Asp Pro Thr Val Phe Arg Asp Arg Ala Phe Ser Val 
        275                 280                 285             


Ala Val Val Ser Val Val Leu Ala Met Phe Ala Met Gly Gly Ile Met 
    290                 295                 300                 


Leu Leu Leu Thr Gln His Trp Gln Phe Val Gly Gly Ala Ser Pro Met 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Leu Leu Pro Val Leu Leu Ala Thr Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Val Ser Val Ile Val Pro Arg Tyr Gly Thr Lys Tyr Ala 
            340                 345                 350         


Met Ile Ile Gly Met Gly Leu Ile Gly Ala Ala Phe Phe Val Leu Met 
        355                 360                 365             


Asn Val Glu Pro Asp Thr Glu Trp Trp Val Phe Ala Ile Ala Leu Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Ile Met Ser Thr Ala Asp Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
                405                 410                 415     


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
            420                 425                 430         


Gly Ser Val Ala Thr Ala Leu Phe Arg Arg Glu Met Asp Asp Pro Ile 
        435                 440                 445             


Ala Gly Val Asp Pro Lys Ala Met Asp Ala Gly Arg Glu Ala Leu Pro 
    450                 455                 460                 


Asp Ala Val Gly Val Gly Gly Gly Leu Pro Gly Ala Leu Ala Glu Asp 
465                 470                 475                 480 


Val Lys Arg Arg Ala Asp Asn Ala Phe Thr Asp Ala Phe Gly Ile Thr 
                485                 490                 495     


Ser Leu Cys Thr Gly Val Ile Leu Val Val Val Ala Val Ala Val Phe 
            500                 505                 510         


Leu Phe Ile Pro Pro Ser Ala Gly Arg Ile Thr Pro Ala Thr Glu Gly 
        515                 520                 525             


Gly Gly Asp Gly Pro Glu Glu Gly Val Asp Leu Ile Lys Gln Glu Ser 
    530                 535                 540                 


Arg Glu Ser Ala Asp Ala Arg Pro Thr Pro Val Glu Arg Pro 
545                 550                 555             


<210>  142
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of pamW polypeptide

<400>  142

Met Glu Ala Val Val His Glu Gln Gln Gly Ala Gly Arg Gly Gly Gly 
1               5                   10                  15      


Glu Gly Gly Asp Glu Ala Gly Val Pro Gly Ala Arg Asn Arg Trp Ala 
            20                  25                  30          


Val Leu Gly Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Ile 
        35                  40                  45              


Thr Val Val Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Arg Pro 
    50                  55                  60                  


Ser Ser Val Gln Leu Leu Trp Ile Leu Asp Val Tyr Ser Leu Val Leu 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
                85                  90                  95      


Lys Arg Phe Leu Cys Leu Gly Phe Ile Val Phe Gly Gly Ala Ser Ala 
            100                 105                 110         


Ala Ala Ala Trp Ala Ser Gly Pro Ala Ile Leu Ile Thr Ala Arg Ala 
        115                 120                 125             


Leu Val Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Ile Ser Ile 
    130                 135                 140                 


Ile Arg Gln Val Phe Thr Asp Arg Lys Glu Arg Thr Met Ala Leu Ala 
145                 150                 155                 160 


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
                165                 170                 175     


Gly Gly Ile Met Ile Glu His Tyr Trp Trp Gly Ser Val Phe Leu Ile 
            180                 185                 190         


Asn Val Pro Ile Met Val Leu Ala Leu Ile Ala Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Thr Arg His Pro Asn Pro Pro Arg Trp Asp Thr Ala Gly Ala 
    210                 215                 220                 


Leu Leu Ser Val Thr Gly Leu Val Ser Leu Val Tyr Gly Ile Gln His 
225                 230                 235                 240 


Gly Gly Ala Lys Gly Leu Glu Ala Gln Thr Leu Ile Ser Gly Ile Leu 
                245                 250                 255     


Gly Leu Leu Leu Leu Thr Gly Leu Val Val Arg Val Leu Arg Ile Lys 
            260                 265                 270         


Asp Pro Ile Phe Asp Pro Thr Val Phe Lys Asp Arg Ala Phe Ser Leu 
        275                 280                 285             


Ala Leu Val Ser Ile Val Leu Ala Ile Phe Gly Met Gly Gly Leu Met 
    290                 295                 300                 


Leu Leu Leu Thr Gln His Trp Gln Phe Leu Gly Gly Ala Ser Pro Met 
305                 310                 315                 320 


Glu Ser Gly Leu Gln Ile Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
                325                 330                 335     


Ala Pro Ile Met Ser Val Ile Val Pro Arg Trp Gly Thr Arg Tyr Ala 
            340                 345                 350         


Met Met Leu Gly Ile Gly Leu Ile Gly Ala Ala Trp Phe Val Leu Val 
        355                 360                 365             


Asn Val Glu Pro Asp Thr Glu Tyr Trp Val Tyr Gly Ile Ala Leu Ala 
    370                 375                 380                 


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Ile Val Ser Thr Ala Asp Ala Asp Thr Ala Gly Gly Ala Gly Gly Ile 
                405                 410                 415     


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
            420                 425                 430         


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Met Asp Asp Pro Leu 
        435                 440                 445             


Ala Ala Val Asp Pro Lys Ala Leu Asp Ala Ala Arg Glu Gly Leu Pro 
    450                 455                 460                 


Asp Ala Met Gly Val Ala Gly Ala Leu Pro Gly Ala Ile Gly Glu Asp 
465                 470                 475                 480 


Leu Lys Arg Arg Ala Asp Asn Ala Phe Thr Asp Ala Trp Gly Val Thr 
                485                 490                 495     


Ser Leu Cys Thr Gly Val Ile Leu Val Val Val Ala Val Ala Val Phe 
            500                 505                 510         


Leu Phe Leu Pro Pro Ser Ala Gly Arg Ile Thr Pro Ala Thr Asp Gly 
        515                 520                 525             


Gly Gly Asp Ala Pro Asp Asp Gly Leu Asp Leu Val Lys Gln Glu Thr 
    530                 535                 540                 


Arg Asp Ser Ala Asp Gly Arg Pro Thr Pro Val Asp Arg Pro 
545                 550                 555             


<210>  143
<211>  391
<212>  DNA
<213>  Streptomyces alboniger

<400>  143
agacgatgtc caggaattgc gcggacgtcg cgcacagtcc tcctgggccg ggcagggcga       60

atcccatgcc cgtgatcagt gcgtcgcgac cgggatcctg ctgctgatgc gccatgagac      120

tccctgtgtt gcgtgccgct gtcgacaggc cgccgacgct agagcggtgc gggtcggggc      180

gtaaccggct cctggtaccc ggtttccgcc accacaggta tcagtagtac tgaaatcaat      240

aattggtact tcaagtacca cagggggatt ctcccgggta ccggtgggcc gatgtccctc      300

gaattcccgg cggatagctt tcccgtatgg ctgcacaggc tgaatccgct gcacggaaaa      360

accgcgggga ctccgtactc gtcactagaa t                                     391


<210>  144
<211>  288
<212>  DNA
<213>  Streptomyces alboniger

<400>  144
tacgggaagt ggtcagccac ttcgggcggt tccggcgcga gcaggacaca cggggggcct       60

tccgcctcgc cacctggctg ccgctcaacg acggcccggc ctcccccgag gaggccgtgg      120

cggcgctgac ccgctggccg gtgagcggcg cgggctgcac ggcggaaccg caggtcaccg      180

aggcggagat cgcctggctg cgcagtctcg atccgcaagg tttctacagg tgacgcgatc      240

cgcaggatcc caccaggtga ggagcacgga tggtacccca gattccac                   288


<210>  145
<211>  257
<212>  DNA
<213>  Streptomyces alboniger

<400>  145
ggaatgtcca acggggtgtt gtcccacgat tgattacgtg acattgaatg actccgagtg       60

ccggcctgac cagcccgccc cctggagtca gccgtgcggg aggccacggg cccacgcagc      120

gactgaccca gctcgtctga taccgctcgt ctcgacgcgc cgccctcggg gcggcatccg      180

gagcgtggcg caggcacatc tcggagcatt gcagacctga ctacccatcc gctgcactca      240

ctgcgtgagg agtcccc                                                     257


<210>  146
<211>  986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cluster 5-prime probe

<400>  146
gccaaacaag tctccctgat cgaggagtgg ttgaggcagc aggcgggcgt ggcccgggtc       60

aacaccttcg ggcccgacct cggcggctgt ctcgacgaca aggacggctg ccccatcctg      120

atcgaacagg tgcggtcgta caaggacccg gccgttcagg gcgccgcact ccaaacggaa      180

ggcgaccggc tctcgttccg ggtcgaagtg ggccgatagc agccgtcggc cgcccgatgg      240

cgtcgtcggc ataaccggct agcctttaga gtgagtccat ggatcttgcg gacgacctga      300

tcacccgacc gtacgacgtg taccgggact tgcgcaccac ctctcccgtg caccgcgtca      360

ccgggaccga cggtcgaccc gcctggctcg tcacccggta cgacgacgta cgcgccgctc      420

tcgccgaccc tcggctctcg ctcgacaaaa cgaacgcgcg ggagggcaac taccgcgggc      480

tggcgctgcc ccccgccctc gacgcgaacc tcctcaacat ggaccctccc gaccacacac      540

gcctgcgccg cctggtcgga cgagccttca ccccccgccg cgtggagcaa ctgcgcacgc      600

cgatacgggc caccgccgac cggctcctgg acgcgctggg cacacacggc acgaccgacc      660

tggtgaccgc ctacgcggcc ccccctgccg atcaccgtca tctgtgaact cctgggcatc      720

ccggaaaacc gccgacggga cttccggtcc tggtcgaacg tgctggtcgc gcccgacccc      780

agccggcccc aggtcgccaa ggaggccttc gcgggcatgc tggggttcct cgcggaactc      840

ctggttcaca agaggagcag ccccgcggac gacctgctct ccgacctgat cgccgtccgg      900

gacgcggacg acgaccggct caccgaggac gagctgatgt ccctggcatt cctcatcctc      960

ttcgccggct acgagaacac cgtcca                                           986


<210>  147
<211>  1051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cluster 3-prime probe

<400>  147
cagcgccgac gacgagatcg tacgtccgct gctcaccgct ggagaacgtg acggtgccct       60

cggcgctgat gtcggtcacg gcggtgccga gccgtatgcc cggggcaacg agcgaggagc      120

gcagcatgac gtgcagttcg ctccggctga tcgcgaagca gccgcccacc tcgccccaga      180

tcgtgctgag ggggaactcc gccaggacgc ggccgcggtg gtcgaggatc cgctgccgtg      240

tcacggggtg cgcccggcct acgagttcat cgcccaagcc caactgcttc agtgcgcgca      300

ccgcattggc cggaagatac aacccggttc ccgcggaacg tagttcaccg tcgcgctcca      360

ctacgtctgc actcatgccg ttgccctcga gggcccgggc cagggacagc cccgcgatcc      420

cggcgccgac gatgagtatg cgaagttccg ccatgctgaa ttccttgatc cgtgtggtgg      480

aggtgcgggg cctggaggag aggtaaccct gcgatagacg gcgtgcaggt gctgcggctg      540

atagttccag acgctgccgc gcgccacgac cagcggtgcg tttcggggag cggttcccag      600

gaccggtaca gctgctgatc accccggccg gcccttgtgg tcccggcggc gcaccgcgct      660

ctccatcctg ggaccgcggc gccgtccacg taccagccac cacgtcgtcc gccgctgttc      720

atgagccgcc ggacaactgc gttctcggtg ttcctgcccg cgaacggcgc ggtggtcgac      780

gcgccgcacc tgcaaccgcc aagcccgctg tccgccgcgc cggtcccgcg ccaagccgcc      840

gctgccgcgg agactctcga cgcccggcgc gcggtgccga tgcactacga ggccgagcag      900

ccggacaaga tcgcgggcta cgtcgaagcc gccgacccgg agggcgagtt cggcacgcac      960

gcgggagggc gcgcacacgt gctggccgtc ggggaatgac tggacctggc cacgtgaccg     1020

gaaaccgcgg ggcgaagcca agggcgatag c                                    1051


<210>  148
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0729ACPDF primer

<400>  148
ccgacgcagc gtcccccgga ggaaacggtg tacgaatcga ttccggggat ccgtcgacc        59


<210>  149
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0729ACPDR primer

<400>  149
ccgtgcgcac cgcgctctcc agggacctgg gcacggctct gtgtaggctg gagctgcttc       60


<210>  150
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0729CheckF   primer

<400>  150
ccggaggaaa cggtgtacg                                                    19


<210>  151
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0729CheckR  primer

<400>  151
ctctccaggg acctgggca                                                    19


<210>  152
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0730DelHygMF primer

<400>  152
atggaccaca acaggacacg cgcggccgtg ctggcgggcg tcgacccggt accggagta        59


<210>  153
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0730DelHygMR primer

<400>  153
cgcggtacgt atgcacggcc agggccgtga cgtccggcca cactacgccc ccaactgaga       60

g                                                                       61


<210>  154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0730checkF  primer

<400>  154
atggaccaca acaggacacg                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0730checkR primer

<400>  155
gaccgattcg tacaccgttt                                                   20


<210>  156
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0731DF primer

<400>  156
acagcggcac gcaacacagg gagtctcatg gcgcatcaga ttccggggat ccgtcgacc        59


<210>  157
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0731DR primer

<400>  157
ccatgtccgc gggcctcacg ccttccccag caggatcgct gtgtaggctg gagctgcttc       60


<210>  158
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0731CheckF  primer

<400>  158
tgtcgacagc ggcacgcaa                                                    19


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0731CheckR

<400>  159
tgtcctgttg tggtccatgt                                                   20


<210>  160
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0732DF primer

<400>  160
attcccggcg gatagctttc ccgtatggct gcacaggcta ttccggggat ccgtcgacc        59


<210>  161
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0732DR primer

<400>  161
gtccgcgcgg gttcggcacc ggtcatgcgg cgccgagtgt gtgtaggctg gagctgcttc       60


<210>  162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0732CheckF

<400>  162
ggtacttcaa gtaccacagg                                                   20


<210>  163
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0732CheckR  primer

<400>  163
aggacgatgg tccgctcct                                                    19


<210>  164
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0733ATDF  primer

<400>  164
ggtgccgaac ccgcgcggac cgaacccctg aaggagacca ttccggggat ccgtcgacc        59


<210>  165
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0733ATDR primer

<400>  165
tcacctggtg ggatcctgcg gatcgcgtca cctgtagaat gtgtaggctg gagctgcttc       60


<210>  166
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0733CheckF  primer

<400>  166
ttcgccatcg gcagccaga                                                    19


<210>  167
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0733CheckR primer

<400>  167
gctcctcacc tggtgggat                                                    19


<210>  168
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0737KRDF primer

<400>  168
gtgaacggcc atgtccgatt ccaggaatgc gctggtgacc attccgggga tccgtcgacc       60


<210>  169
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0737KRDR primer

<400>  169
ggcgtcgtta cggaacccag ccgggcggcc cgccgccgtc tgtaggctgg agctgcttc        59


<210>  170
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0737checkF  primer

<400>  170
gtgaacggcc atgtccgat                                                    19


<210>  171
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0737checkR

<400>  171
ggcgtcgtta cggaaccca                                                    19


<210>  172
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0740DF primer

<400>  172
atgcggtgac cacgaccaag ggcccccggg acgcactcga ttccggggat ccgtcgacc        59


<210>  173
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0740DR primer

<400>  173
cgggcccggc gccgggcggc gtgtgctcag tcatcggtgt gtgtaggctg gagctgcttc       60


<210>  174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0740CheckF   primer

<400>  174
tgtaccggat ctgagcgaag                                                   20


<210>  175
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0740CheckR primer

<400>  175
agggagcccg tttcgagca                                                    19


<210>  176
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0743DhygMF  primer

<400>  176
gcccgggatc cctgaatgac gggccccacg acgtcagcgt cgacccggta ccggagta         58


<210>  177
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0743DhygMR

<400>  177
gtcacgggtg acctcgatcc cggccgccac gcggtcccaa ctacgccccc aactgagag        59


<210>  178
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0743CheckF primer

<400>  178
ttggtcaact gggagcagta                                                   20


<210>  179
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0743CheckR primer

<400>  179
ggtcacgggt gacctcgat                                                    19


<210>  180
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0745hygDF primer

<400>  180
gagagcacct atccagcaga gaaagggacc catcgtgatt cgacccggta ccggagta         58


<210>  181
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0745hygDR primer

<400>  181
aaaacgcgtt gccgtcccgt ggccctgacg agtcatccca ctacgccccc aactgagag        59


<210>  182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0745CheckF2 primer

<400>  182
acagaaccag cacgtatcca                                                   20


<210>  183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0745CheckR2 primer

<400>  183
cattggacat gtcgtcactc                                                   20


<210>  184
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0746MtDF primer

<400>  184
gtgagtgacg acatgtccaa tgcgcacacc gatcgcaaga ttccggggat ccgtcgacc        59


<210>  185
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0746MtDR primer

<400>  185
tcactgcttg cggtagacgg acaccgcgtc cctgctgtcg tgtaggctgg agctgcttc        59


<210>  186
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0746CheckF2  primer

<400>  186
gatgactcgt cagggccac                                                    19


<210>  187
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0746CheckR2 primer

<400>  187
atgcctgtac gggcaggtt                                                    19


<210>  188
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0749DF primer

<400>  188
atgcaagcgt taggtgtact cgtcgtcgat cgccacccca ttccggggat ccgtcgacc        59


<210>  189
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0749DR  primer

<400>  189
tcaaccccgg gccccggtgg tcaccccggt cggagaggag tgtaggctgg agctgcttc        59


<210>  190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0749CheckF  primer

<400>  190
gcactcactg cgtgaggagt                                                   20


<210>  191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0749CheckR primer

<400>  191
tgagttcgtc cgggaacgtc                                                   20


<210>  192
<211>  273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promoter ermeE*p

<400>  192
atcctaccaa ccggcacgat tgtccagccc acaacagcat cgcggtgcca cgtgtggacc       60

gcgtcggtca gatcctcccc gcacctctcg ccagccgtca agatcgaccg cgtgcacctg      120

cgatcgccga tcaaccgcga ctagcatcgg gcgcaagccg ccactcgaac ggacactcgc      180

atggacgtcc ccttcctgga cctgcaagcc gcgtacctcg aactccggtc cgacatcgac      240

caggcgtgcc ggcgcgtgct cgggtcgggc tgg                                   273


<210>  193
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promoter p21

<400>  193
tgtgcgggct ctaacacgtc ctagtatggt aggatgagca a                           41


<210>  194
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamF 0731DF

<400>  194
acagcggcac gcaacacagg gagtctcatg gcgcatcagt cgacccggta ccggagta         58


<210>  195
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamF  0731DR

<400>  195
ccatgtccgc gggcctcacg ccttccccag caggatcgac tacgccccca actgagag         58


<210>  196
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamG  0730DelHygMF

<400>  196
atggaccaca acaggacacg cgcggccgtg ctggcgggcg tcgacccggt accggagta        59


<210>  197
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamG  0730DelHygMR

<400>  197
gccgcggtac gtatgcacgg ccagggccgt gacgtccggc cacactacgc ccccaactga       60

gag                                                                     63


<210>  198
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamJ  0740DF

<400>  198
atgcggtgac cacgaccaag ggcccccggg acgcactcgt cgacccggta ccggagta         58


<210>  199
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamJ  0740DR

<400>  199
cgggcccggc gccgggcggc gtgtgctcag tcatcggtgt actacgcccc caactgagag       60


<210>  200
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamX  0745hygDF

<400>  200
gagagcacct atccagcaga gaaagggacc catcgtgatt cgacccggta ccggagta         58


<210>  201
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamX  0745hygDR

<400>  201
aaaacgcgtt gccgtcccgt ggccctgacg agtcatccca ctacgccccc aactgagag        59


<210>  202
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamY  0746DelF3

<400>  202
gcagtggcag gaagaggcgg cggaggagtg ggaccggttt cgacccggta ccggagta         58


<210>  203
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamY  0746DelR3

<400>  203
gtggaagggc tccttgcgcc agcctcccca gcggtcctct actacgcccc caactgagag       60


<210>  204
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamK  0738DelHygMF

<400>  204
gtgaactacg gctttttcgc ggggtacttc gagtacccgc tcgacccggt accggagta        59


<210>  205
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamK  0738DelHygMR

<400>  205
tcagatccgg tacaggaggc tgccccagca ccagacgccg actacgcccc caactgagag       60


<210>  206
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamL  0743DhygMF2

<400>  206
gcccgggatc cctgaatgac gggccccacg acgtcagcgt cgacccggta ccggagta         58


<210>  207
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pamL  0743DhygMR2

<400>  207
gtcacgggtg acctcgatcc cggccgccac gcggtcccaa ctacgccccc aactgagag        59


<210>  208
<211>  231
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  208
gtgtacgaaa cggtaaagtc cctgctcacc aacgacttcg acgtctccga ggatcagatc       60

gccccggaat ccacgctgga ggatctgggc ctggactccc tggcctcggt cgagttcgcc      120

ctcgccctgg agaaggggct cggtgtggag atcacggacg acgaggtggt ggagctggag      180

cggctcgaca agattctgga actggtcgag cgccgcaagc gcgcgtcctg a               231


<210>  209
<211>  76
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  209

Met Tyr Glu Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Val Ser 
1               5                   10                  15      


Glu Asp Gln Ile Ala Pro Glu Ser Thr Leu Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Glu Val Val Glu Leu Glu Arg Leu Asp Lys 
    50                  55                  60                  


Ile Leu Glu Leu Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  210
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamC polypeptide

<400>  210

Met Tyr Glu Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Leu Ser 
1               5                   10                  15      


Glu Glu Gln Ile Ala Pro Glu Ser Thr Val Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Glu Val Val Glu Ile Glu Arg Leu Asp Lys 
    50                  55                  60                  


Ile Leu Glu Leu Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  211
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamC polypeptide

<400>  211

Met Tyr Glu Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Val Ser 
1               5                   10                  15      


Glu Glu Gln Ile Ala Pro Glu Ser Ser Val Glu Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Ala Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Glu Glu Val Val Glu Leu Glu Arg Leu Asp Lys 
    50                  55                  60                  


Ile Leu Glu Leu Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  212
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamC polypeptide

<400>  212

Met Tyr Glu Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Val Ser 
1               5                   10                  15      


Glu Asp Gln Ile Ala Pro Asp Ser Thr Leu Asp Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Leu Gly Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Glu Val Val Glu Ile Glu Arg Leu Asp Lys 
    50                  55                  60                  


Leu Leu Glu Val Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  213
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamC polypeptide

<400>  213

Met Tyr Asp Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Leu Ser 
1               5                   10                  15      


Glu Glu Gln Ile Ala Pro Glu Ser Thr Leu Asp Asp Leu Gly Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Val Ala Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Glu Asp Glu Ile Ile Glu Leu Glu Arg Leu Asp Lys 
    50                  55                  60                  


Ile Leu Glu Leu Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  214
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamC polypeptide

<400>  214

Met Tyr Glu Thr Val Lys Ser Leu Leu Thr Asn Asp Phe Asp Val Ser 
1               5                   10                  15      


Glu Asp Gln Ile Ala Pro Glu Ser Thr Val Glu Asp Leu Gly Ile Asp 
            20                  25                  30          


Ser Leu Ala Ser Val Glu Phe Ala Met Gly Leu Glu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Thr Asp Asp Asp Met Val Glu Ile Glu Arg Leu Asp Lys 
    50                  55                  60                  


Met Leu Glu Leu Val Glu Arg Arg Lys Arg Ala Ser 
65                  70                  75      


<210>  215
<211>  1035
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  215
atggacaccc acaggacccg cgcggccgta ctgacgggcg tcgccggctg ggtaccgccc       60

ggcacggtca ccaacgccga gctggaggcc cgcctggaca ccaccgacga gtggatccgc      120

agccgcaccg gcatcgccga gcggcacatc gtcccgccgg gcacggccac gcgcgaactg      180

gccgtcgagg cggggaagct ggccctgaag tcggcgggcc gcgacagtgt ggacgccgtc      240

gtcctcgcga cggcgacccc ggaccgcctc tgcccggcca ccgcccccga ggtcgcgtcg      300

gcactcgggc tcggtccggt cgccgcgcac gacgtcgccg ccgtctgcgc cgggttcctg      360

tacgcgctgt cggccggggt cggggcgatc gccgcgggct tcgccgagca cgtcctcgtc      420

atcggtgccg agacgttctc caccatcgtc gacccggagg accggaacac ggccgtcatc      480

ttcggcgacg ccgccggtgc cgtcgtgctg cgcgccgggg acccggacga gccgggggcc      540

atcggtccga tccggctcgg cagcgacggc acgcacagcg acctgatcca gatccccgcc      600

ggcggcgccc ggcagcgctc cgcgggcacg gctccgggcg cgagcgacca ccacctgcag      660

atgcagggac gaaaggtcta ccggcacgcc aaggagcgca tgacccagtc ggcactcgag      720

gtgctggagc gctccaactg ggccgtcgcg gacgtggatc gcctggccac ccatcaggcc      780

aacgcccgca tcagcgaggc cgtcgccgat gagctgggca tcccgcacga ccgggtcctg      840

tccaacatcg agcgcgtcgg caacacggcc gccgcgtccc tgccgctgct gctcgccgac      900

tccgcgtcgg aggggaaact gcgtccgcgc gaccgggtgc tgctcgcggc gttcggcggc      960

gggctcgcct ggggggcggc ggcgctgacc tggccggacg tgacggccct cgcggtgcac     1020

acctatcgcg ggtga                                                      1035


<210>  216
<211>  344
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  216

Met Asp Thr His Arg Thr Arg Ala Ala Val Leu Thr Gly Val Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Ile Val Pro Pro Gly Thr Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Lys Leu Ala Leu Lys Ser Ala Gly Arg Asp Ser Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ser Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Thr Ile Val Asp Pro Glu Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Asp Leu Ile Gln Ile Pro Ala Gly Gly Ala Arg Gln Arg Ser Ala 
        195                 200                 205             


Gly Thr Ala Pro Gly Ala Ser Asp His His Leu Gln Met Gln Gly Arg 
    210                 215                 220                 


Lys Val Tyr Arg His Ala Lys Glu Arg Met Thr Gln Ser Ala Leu Glu 
225                 230                 235                 240 


Val Leu Glu Arg Ser Asn Trp Ala Val Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Glu Ala Val Ala Asp Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Arg Val Leu Ser Asn Ile Glu Arg Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ser Glu 
    290                 295                 300                 


Gly Lys Leu Arg Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ala Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  217
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamG polypeptide

<400>  217

Met Asp Thr His Arg Thr Arg Ala Ala Val Leu Thr Gly Leu Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Val 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Ile Val Pro Pro Gly Thr Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Leu Ala Leu Lys Ser Ala Gly Arg Asp Ser Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ser Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Val Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Gly Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Tyr Ser Thr Ile Val Glu Pro Glu Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Ala Gly Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Asp Leu Val Gln Ile Pro Ala Gly Gly Ala Arg Gln Arg Ser Ala 
        195                 200                 205             


Ala Thr Ala Pro Ala Ala Ser Asp His His Leu Gln Met Gln Gly Arg 
    210                 215                 220                 


Lys Val Tyr Lys His Ala Lys Asp Arg Met Thr Gln Ser Ala Leu Glu 
225                 230                 235                 240 


Val Leu Glu Lys Ser Asn Trp Ala Ile Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Glu Ala Leu Ala Asp Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Arg Val Leu Ser Asn Ile Glu Arg Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ser Glu 
    290                 295                 300                 


Gly Arg Leu Arg Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ala Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  218
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamG polypeptide

<400>  218

Met Asp Thr His Arg Thr Arg Ala Gly Val Leu Thr Gly Val Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Ile 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Ile Val Pro Pro Gly Thr Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Lys Leu Ala Leu Lys Ser Ala Gly Arg Asp Ser Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Gly Thr Ala Pro 
                85                  90                  95      


Asp Val Ala Ser Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Thr Ile Val Asp Pro Glu Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Glu Pro Asp 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Leu Gly Ser Asp Gly Ser His 
            180                 185                 190         


Ser Asp Leu Ile Gln Leu Pro Ala Gly Gly Ala Arg Gln Arg Ser Ala 
        195                 200                 205             


Gly Ser Ala Pro Gly Ala Ser Glu His His Leu Gln Met Gln Gly Arg 
    210                 215                 220                 


Lys Val Phe Arg His Ala Lys Glu Arg Met Thr Gln Ser Ala Leu Glu 
225                 230                 235                 240 


Val Leu Glu Arg Ser Asn Trp Ala Val Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Gly Arg Ile Ser Glu Ala Val Ala Glu Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Lys Val Val Ser Asn Ile Glu Arg Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ser Asp 
    290                 295                 300                 


Gly Arg Leu Lys Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ala Leu Ser Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  219
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamG polypeptide

<400>  219

Met Asp Thr His Arg Thr Arg Ala Ala Val Leu Ser Gly Ile Ala Gly 
1               5                   10                  15      


Trp Val Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Val 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Arg Thr Gly Ile Gly Glu Arg 
        35                  40                  45              


His Val Leu Pro Pro Gly Thr Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Lys Leu Ala Leu Lys Ser Ala Gly Arg Glu Ser Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Gly Ser Ala Pro 
                85                  90                  95      


Glu Val Ala Ser Ala Leu Gly Leu Gly Pro Ile Ala Gly His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Leu Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Thr Met Val Asp Pro Glu Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Glu 
                165                 170                 175     


Glu Pro Gly Ala Ile Gly Pro Ile Arg Leu Ala Thr Asp Gly Thr His 
            180                 185                 190         


Ser Asp Leu Ile Asn Leu Pro Ala Gly Gly Ala Arg Gln Arg Thr Gly 
        195                 200                 205             


Gly Thr Ala Pro Gly Ala Ser Asp His His Leu Gln Met Gln Gly Lys 
    210                 215                 220                 


Lys Val Tyr Arg His Gly Lys Glu Arg Val Thr Gln Ser Ala Leu Glu 
225                 230                 235                 240 


Val Leu Glu Arg Ser Asn Trp Ala Leu Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Ala Arg Ile Ser Glu Ala Val Ala Asp Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Arg Val Leu Ser Asn Ile Glu Arg Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Val Leu Ala Asp Ser Ala Ser Glu 
    290                 295                 300                 


Gly Lys Leu Arg Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Ile Ala Trp Gly Ala Ala Ala Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  220
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamG polypeptide

<400>  220

Met Asp Thr His Arg Thr Arg Ala Ala Val Leu Thr Gly Val Ala Gly 
1               5                   10                  15      


Trp Ile Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Lys Leu 
            20                  25                  30          


Asp Thr Thr Asp Asp Trp Ile Arg Ser Arg Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Val Met Pro Pro Gly Thr Ala Ser Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Lys Leu Ala Leu Lys Ser Ala Gly Arg Asp Ser Val Asp Ala Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Ile Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ser Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Ile Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Thr Val Val Asp Pro Glu Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Asp Pro Gly Ala Leu Gly Pro Ile Arg Leu Gly Ser Asp Gly Ser His 
            180                 185                 190         


Thr Asp Met Val Gln Met Pro Gly Ala Gly Ala Lys Gln Arg Ser Ala 
        195                 200                 205             


Ala Thr Ala Pro Gly Ala Ser Asp His His Leu Gln Ile Gln Gly Lys 
    210                 215                 220                 


Arg Val Phe Lys His Ala Lys Glu Arg Met Thr Gln Thr Ala Leu Glu 
225                 230                 235                 240 


Val Leu Glu Arg Thr Asn Trp Ala Val Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Gly Arg Ile Ser Glu Ala Ile Ala Asp Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Lys Leu Ile Ser Asn Ile Glu Lys Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Leu Leu Ala Asp Ser Ala Ser Glu 
    290                 295                 300                 


Gly Lys Leu Lys Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ala Leu Thr Trp Pro Glu Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  221
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamG polypeptide

<400>  221

Met Asp Thr His Arg Thr Arg Ala Ala Val Leu Thr Gly Ile Ala Gly 
1               5                   10                  15      


Trp Leu Pro Pro Gly Thr Val Thr Asn Ala Glu Leu Glu Ala Arg Leu 
            20                  25                  30          


Asp Thr Thr Asp Glu Trp Ile Arg Ser Lys Thr Gly Ile Ala Glu Arg 
        35                  40                  45              


His Val Val Pro Pro Gly Thr Ala Thr Arg Glu Leu Ala Val Glu Ala 
    50                  55                  60                  


Gly Arg Ile Ala Leu Lys Ser Ala Gly Arg Glu Ser Val Asp Gly Val 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Pro Asp Arg Leu Cys Pro Ala Thr Ala Pro 
                85                  90                  95      


Glu Val Ala Ser Ala Leu Gly Leu Gly Pro Val Ala Ala His Asp Val 
            100                 105                 110         


Ala Ala Val Cys Ala Gly Phe Ile Tyr Ala Leu Ser Ala Gly Val Gly 
        115                 120                 125             


Ala Ile Ala Ala Gly Phe Ala Glu His Val Leu Val Ile Gly Ala Glu 
    130                 135                 140                 


Thr Phe Ser Thr Leu Val Asp Pro Asp Asp Arg Asn Thr Ala Val Ile 
145                 150                 155                 160 


Phe Gly Asp Ala Ala Gly Ala Val Val Leu Arg Ala Gly Asp Pro Asp 
                165                 170                 175     


Glu Pro Gly Gly Met Ala Pro Ile Arg Leu Gly Ser Asp Gly Thr His 
            180                 185                 190         


Ser Asp Leu Met Gln Ile Pro Gly Ala Gly Ala Arg Gln Arg Thr Ala 
        195                 200                 205             


Gly Thr Ala Pro Gly Ala Ser Asp His His Ile Gln Met Gln Gly Lys 
    210                 215                 220                 


Lys Val Tyr Lys His Ala Lys Asp Arg Ile Thr Gln Thr Ala Leu Asp 
225                 230                 235                 240 


Ile Leu Glu Arg Ser Asn Trp Ala Met Ala Asp Val Asp Arg Leu Ala 
                245                 250                 255     


Thr His Gln Ala Asn Gly Arg Ile Ser Asp Ala Leu Ala Glu Glu Leu 
            260                 265                 270         


Gly Ile Pro His Asp Arg Val Leu Thr Asn Ile Glu Arg Val Gly Asn 
        275                 280                 285             


Thr Ala Ala Ala Ser Leu Pro Leu Leu Leu Ala Glu Ser Ala Thr Glu 
    290                 295                 300                 


Gly Lys Val Arg Pro Arg Asp Arg Val Leu Leu Ala Ala Phe Gly Gly 
305                 310                 315                 320 


Gly Leu Ala Trp Gly Ala Ala Ala Leu Thr Trp Pro Asp Val Thr Ala 
                325                 330                 335     


Leu Ala Val His Thr Tyr Arg Gly 
            340                 


<210>  222
<211>  1320
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  222
atggcggacc agcagcagga tcccggtcgc gacacattga tcacgggcat gggattcgcc       60

ctgcccggcc ctggcggact gtgcgcgact tccgcggaat tcctggacat cgtctccacc      120

ggcgcctgcc atgtggaaaa cgacggtgtc ttcttcggtc aagtacgcac cgatatcgcg      180

gatgtgaagg agcgttatcc cgaactcccc gtcaaggcac ttaaactcta ttcccccgtg      240

cagttgctcg gcctgatctc catggcggag gcgtgcggcg acgccggact cgactggcgt      300

tcgggcgcgc tgtcccgggc ggcgatcctc gcggcccgcg acggtggcga ctgctggtcg      360

gcccagtacg ccgacattct ccgcaccgac cgcgccacgg ccaccaagga cgagatcaac      420

gaactcggca cccgcctcgc cctcacgggc atcccgatgg acgtggccaa cgtccaggtg      480

tccgtcgtgg ccgggaccgg ccccaacttc accgtctcca acggctgtac gtcctccgcc      540

gtgttgctcg gcatggcgca ccggatgatc gcgagcggcg aggtggacgt cgccgtcgtc      600

accggcgccg acgtgttcgg cctggacttc ctgcggcact acgccgacct gctcgaccgc      660

tacgccgagc tgagcgccga agagggcgtc accgtcgacg ccatggagga cgcggccctg      720

gccatgggcg cgctgatgcg tccgtacgac aagaactcac cgggctccaa catgggcagc      780

ggctccatca cgatcgtcgt ggagagccgc gcgcacgccg agcggcgcgg cgcgaccccc      840

tacgcccgga tgctggcgca gcgcacccgg cgcagcccgc agcacagcgc cttcgccatc      900

gaccgctcgg ggaccggcat ggtccaggcg gcgcgggacg ccatggcggg cctcgtcgaa      960

ccggaccaga tcgactacgt caacggcggt gccgagggcg accgcgtctt ccacgagacg     1020

gagtcgaaca tcgtgcacag cctcttcggc gagcgcgcgg cccggctgcc cgtcaccgtg     1080

caggaagcct gtttcgggca caacggcggg ccgctcggca acctcggcgt ggcggccacg     1140

tccctgatga tccagcgcga cgcggtgttc ccgacggcgg gctgcgtcga cccggacgac     1200

gcctgtctct tcgacccggt accgggcggc atcgcccggc cgctgcgggt cgaccacgcg     1260

ctgtccttca actacaccgt cggcatggtc agcagcgcga ttctgctggg gaaggcgtga     1320


<210>  223
<211>  439
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  223

Met Ala Asp Gln Gln Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Asp Ile Val Ser Thr Gly Ala Cys His Val Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Lys Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Gly Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Arg Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Gln Tyr Ala Asp Ile Leu Arg 
        115                 120                 125             


Thr Asp Arg Ala Thr Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala His Arg Met Ile Ala Ser 
            180                 185                 190         


Gly Glu Val Asp Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Asp Phe Leu Arg His Tyr Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Val Thr Val Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Leu Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ser Gly 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ala Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Asp Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Asn Ile Val His Ser Leu Phe Gly Glu Arg 
            340                 345                 350         


Ala Ala Arg Leu Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Leu Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  224
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamF polypeptide

<400>  224

Met Ala Asp Gln Gln Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Asp Ile Val Ser Thr Gly Ala Cys His Val Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Lys Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Gly Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Arg Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Gln Tyr Ala Asp Ile Leu Arg 
        115                 120                 125             


Thr Asp Arg Ala Thr Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Met Ala His Arg Met Ile Ala Ser 
            180                 185                 190         


Gly Glu Val Asp Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Asp Phe Leu Arg His Tyr Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Val Thr Val Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Leu Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ser Gly 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ala Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Asp Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Asn Ile Val His Ser Leu Phe Gly Glu Arg 
            340                 345                 350         


Ala Ala Arg Leu Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Leu Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  225
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamF polypeptide

<400>  225

Met Ala Glu Gln Gln Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Gly Val Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Asp Ile Val Ser Thr Gly Ala Cys His Val Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Glu 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Arg Ala Leu Lys Ile Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Gly Leu Ile Ser Met Ala Asp Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Arg Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Ser Ala Asn Tyr Ala Asp Leu Leu Arg 
        115                 120                 125             


Thr Asp Arg Ala Thr Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Ile Gly Leu Thr Gly Ile Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Ile Val Ala Gly Thr Gly Pro Asn Tyr Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Val Ala His Arg Met Ile Ala Ser 
            180                 185                 190         


Gly Glu Val Asp Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Asp Phe Val Arg His Phe Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Ile Thr Val Asp Ala Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Leu Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Ser Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ser Gly 
    290                 295                 300                 


Ser Gly Met Val Gln Ala Ala Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Glu Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Gln Ile Val His Ser Leu Phe Gly Asp Arg 
            340                 345                 350         


Ala Gly Arg Val Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Thr Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Leu Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  226
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamF polypeptide

<400>  226

Met Ala Asp Gln Asn Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Ala Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Asp Ile Val Ser Thr Gly Gly Cys His Leu Asp Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Thr Asp Ile Ala Asp Val Lys Asp 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Arg Leu Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Ala Leu Val Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Val Asp Trp Lys Ser Gly Ala Leu Ser Arg Ala Ala Ile Leu Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Trp Thr Ala Asn Tyr Ala Asp Leu Leu Arg 
        115                 120                 125             


Thr Asp Arg Ala Thr Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Gly Ile Pro Met Asp Leu Ala Asn Met Gln Val 
145                 150                 155                 160 


Ser Val Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Met Leu Leu Gly Leu Ala His Arg Met Ile Ala Thr 
            180                 185                 190         


Gly Glu Val Asp Val Ala Val Val Thr Gly Ala Asp Val Phe Gly Leu 
        195                 200                 205             


Asp Phe Leu Arg His Trp Ala Glu Leu Val Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Glu Gly Val Thr Val Asp Gly Met Glu Asp Gly Ala Leu 
225                 230                 235                 240 


Ala Leu Gly Ala Leu Met Arg Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ser Gly 
    290                 295                 300                 


Thr Gly Leu Val Gln Ala Ala Arg Glu Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Asp Gln Ile Asp Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Asn Ile Val His Ser Leu Phe Gly Glu Arg 
            340                 345                 350         


Ala Gly Arg Leu Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Leu Gly Val Ala Ala Thr Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Thr Ala Gly Cys Ile Asp Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Leu Lys 
                405                 410                 415     


Leu Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  227
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamF polypeptide

<400>  227

Met Ala Glu Gln Gln Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Ala Gly Val Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Asp Leu Val Ser Thr Gly Ala Cys His Leu Glu Asn Asp 
        35                  40                  45              


Gly Val Phe Phe Gly Gln Val Arg Ser Asp Val Ala Glu Val Lys Asp 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Lys Ala Leu Arg Val Tyr Ser Pro Val 
65                  70                  75                  80  


Gln Leu Leu Gly Leu Leu Ser Met Ala Glu Ala Cys Ala Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Lys Thr Gly Ala Leu Ser Arg Ala Ala Ile Val Ala Ala 
            100                 105                 110         


Arg Asp Gly Ala Asp Cys Phe Ser Ala Gln Tyr Ala Asp Leu Val Arg 
        115                 120                 125             


Thr Asp Arg Ala Thr Ala Thr Lys Asp Glu Ile Asn Glu Leu Gly Thr 
    130                 135                 140                 


Arg Ile Gly Leu Thr Gly Ile Pro Met Asp Val Gly Asn Met Gln Val 
145                 150                 155                 160 


Ser Leu Val Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Leu Leu Leu Gly Leu Ala His Arg Met Ile Ala Ser 
            180                 185                 190         


Gly Glu Val Asp Val Ala Val Val Thr Gly Ala Asp Val Phe Ala Leu 
        195                 200                 205             


Asp Tyr Leu Arg His Phe Ala Asp Leu Leu Asp Arg Tyr Ala Glu Leu 
    210                 215                 220                 


Ser Ala Glu Asp Gly Val Thr Val Asp Gly Met Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Met Gly Ala Leu Leu Lys Pro Tyr Asp Lys Asn Ser Pro Gly Ser 
                245                 250                 255     


Asn Met Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Ser Pro Gln His Ser Ala Phe Ala Ile Glu Arg Ser Gly 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ala Arg Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Asp Gln Ile Glu Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Val 
                325                 330                 335     


Phe His Glu Thr Glu Ser Gln Ile Val His Ser Leu Phe Gly Asp Arg 
            340                 345                 350         


Ala Gly Arg Val Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Leu Gly Val Ala Ala Thr Ser Leu Ile Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Ser Ala Gly Cys Val Asp Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Met Arg 
                405                 410                 415     


Val Glu His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  228
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamF polypeptide

<400>  228

Met Ala Asp Gln Gln Gln Asp Pro Gly Arg Asp Thr Leu Ile Thr Gly 
1               5                   10                  15      


Met Gly Phe Ala Leu Pro Gly Pro Gly Gly Leu Cys Ala Thr Ser Ala 
            20                  25                  30          


Glu Phe Leu Glu Leu Val Ser Thr Gly Ala Cys His Ile Glu Asn Asp 
        35                  40                  45              


Gly Leu Phe Trp Gly Gln Val Arg Ser Asp Ile Ala Glu Val Lys Asp 
    50                  55                  60                  


Arg Tyr Pro Glu Leu Pro Val Arg Ala Leu Lys Leu Tyr Ser Pro Leu 
65                  70                  75                  80  


Gln Met Leu Ala Leu Ile Ser Met Ala Glu Ala Cys Gly Asp Ala Gly 
                85                  90                  95      


Leu Asp Trp Arg Ser Gly Ala Leu Ser Arg Ala Ala Ile Val Ala Ala 
            100                 105                 110         


Arg Asp Gly Gly Asp Cys Tyr Ser Ala Gln Tyr Ala Asp Ile Leu Arg 
        115                 120                 125             


Thr Asp Lys Ala Ser Ala Thr Lys Asp Glu Ile Asn Glu Ile Gly Thr 
    130                 135                 140                 


Arg Leu Ala Leu Thr Ala Val Pro Met Asp Val Ala Asn Val Gln Val 
145                 150                 155                 160 


Ser Val Leu Ala Gly Thr Gly Pro Asn Phe Thr Val Ser Asn Gly Cys 
                165                 170                 175     


Thr Ser Ser Ala Val Leu Leu Gly Leu Ala His Arg Leu Ile Ala Ser 
            180                 185                 190         


Gly Asp Met Asp Val Ala Val Val Thr Gly Ala Asp Ile Phe Ala Leu 
        195                 200                 205             


Glu Phe Leu Arg His Tyr Ala Asp Leu Leu Glu Arg Tyr Ala Glu Met 
    210                 215                 220                 


Ser Ala Glu Glu Gly Val Thr Val Asp Ala Leu Glu Asp Ala Ala Leu 
225                 230                 235                 240 


Ala Leu Gly Ala Leu Met Arg Pro Tyr Asp Arg Asn Ser Pro Gly Thr 
                245                 250                 255     


Asn Ile Gly Ser Gly Ser Ile Thr Ile Val Val Glu Ser Arg Ala His 
            260                 265                 270         


Ala Glu Arg Arg Gly Ala Thr Pro Tyr Ala Arg Met Leu Ala Gln Arg 
        275                 280                 285             


Thr Arg Arg Thr Pro Gln His Ser Ala Phe Ala Ile Asp Arg Ser Ala 
    290                 295                 300                 


Thr Gly Met Val Gln Ala Ala Lys Asp Ala Met Ala Gly Leu Val Glu 
305                 310                 315                 320 


Pro Asp Gln Ile Glu Tyr Val Asn Gly Gly Ala Glu Gly Asp Arg Leu 
                325                 330                 335     


Phe His Glu Thr Glu Ser Gln Ile Val His Ser Leu Phe Ala Glu Arg 
            340                 345                 350         


Ala Ala Arg Leu Pro Val Thr Val Gln Glu Ala Cys Phe Gly His Asn 
        355                 360                 365             


Gly Gly Pro Leu Gly Asn Met Gly Val Ala Ala Ser Ser Leu Met Ile 
    370                 375                 380                 


Gln Arg Asp Ala Val Phe Pro Thr Ala Gly Cys Val Glu Pro Asp Asp 
385                 390                 395                 400 


Ala Cys Leu Phe Asp Pro Val Pro Gly Gly Ile Ala Arg Pro Leu Arg 
                405                 410                 415     


Val Asp His Ala Leu Ser Phe Asn Tyr Thr Val Gly Met Val Ser Ser 
            420                 425                 430         


Ala Ile Leu Leu Gly Lys Ala 
        435                 


<210>  229
<211>  1245
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  229
atgctccccg gcgcgaccca cgtcaatgaa ttctggcagg acgtgcgcga cggcaattcc       60

cggatcggcc gtctgacccg cgtcgatccg ggccgggccg gcgtccacgc ggccggcgag      120

ctgcgcgact tcgatcaccg gaagttcctg ccggagctga gcgagaaatt cgcgggccgg      180

tacacgcggg acgcactggt gaccatgtcc gccgtggagg aggcccgccg cgacgcgggg      240

ctcgggtccg acgacatcga cccgcggcgc ctgtccctca tcgcctcgtc ctcacgcgga      300

cccctggagt gggtcaacga ggcgctgcgc ggggacgacg acggggccca agaggcgggc      360

ggcgcggacc acttcggcga cagcggcgcc atgctgcgcg gcatgcccgg cgccccggcc      420

acgctgtccg ccatctacgg cgacgtacgc gggttcgtca ccacgctgag cagcgcctgc      480

gtgggcgggc accacgccat cggcttcgcc gccgacctga tccgcgcggg catcgccgac      540

gccgtggtcg tggtgggcta cgaattcccc ctgacacccc tggtgttcca gtccttccgg      600

gcgatgggca accgcgtcct gtcgaccgag tcggacgacc cccggcgcgc gatccgcccc      660

tacacccgtg accgcgaggg cttcgccttc ggcgagggcg ccgtcgccct gtgcctggag      720

cgggagagcc acgcccgggc gcgcggcgcc gggggctacg cccggttcct gtcccaccgg      780

gcgctgaacg aggccaccca ccccttcggc atggacatga gcgggcaggt caccgcctcg      840

gccgtcgccg gcgcactgga ggacgcgggc cggaccccgc gggacgtcga ctggttctgc      900

gcgcacggca ccgcgactcc gaagaacgac gtggcggaga gccggatgct cggcgcgctg      960

tacgagggcc ggccgcggtc cgcctggccg cccctcagct ccgtcaagcc cgtctacggc     1020

cacctgttgg gagcggccgc gctggtgaac gcggccgcca ccgcactggc cctgcaccac     1080

cagtgcctgt gctcgaccgc caactacgcg ggcgccgtac ccgacccgga gtgcgaccac     1140

gaccacgtcg cggagggccc ccgcgcgacc cgcgcggatc tcgcggtgtc cctggcgttc     1200

gccatcggca gccagacctc ggtgctcgcc ctgggcgccg cgtga                     1245


<210>  230
<211>  414
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  230

Met Leu Pro Gly Ala Thr His Val Asn Glu Phe Trp Gln Asp Val Arg 
1               5                   10                  15      


Asp Gly Asn Ser Arg Ile Gly Arg Leu Thr Arg Val Asp Pro Gly Arg 
            20                  25                  30          


Ala Gly Val His Ala Ala Gly Glu Leu Arg Asp Phe Asp His Arg Lys 
        35                  40                  45              


Phe Leu Pro Glu Leu Ser Glu Lys Phe Ala Gly Arg Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Glu Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Leu Gly Ser Asp Asp Ile Asp Pro Arg Arg Leu Ser Leu Ile Ala Ser 
                85                  90                  95      


Ser Ser Arg Gly Pro Leu Glu Trp Val Asn Glu Ala Leu Arg Gly Asp 
            100                 105                 110         


Asp Asp Gly Ala Gln Glu Ala Gly Gly Ala Asp His Phe Gly Asp Ser 
        115                 120                 125             


Gly Ala Met Leu Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala 
    130                 135                 140                 


Ile Tyr Gly Asp Val Arg Gly Phe Val Thr Thr Leu Ser Ser Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala 
                165                 170                 175     


Gly Ile Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr 
            180                 185                 190         


Pro Leu Val Phe Gln Ser Phe Arg Ala Met Gly Asn Arg Val Leu Ser 
        195                 200                 205             


Thr Glu Ser Asp Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp 
    210                 215                 220                 


Arg Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe 
                245                 250                 255     


Leu Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp 
            260                 265                 270         


Met Ser Gly Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Glu Asp 
        275                 280                 285             


Ala Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu 
305                 310                 315                 320 


Tyr Glu Gly Arg Pro Arg Ser Ala Trp Pro Pro Leu Ser Ser Val Lys 
                325                 330                 335     


Pro Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala 
            340                 345                 350         


Ala Thr Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn 
        355                 360                 365             


Tyr Ala Gly Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Ala Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  231
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamA polypeptide

<400>  231

Met Leu Pro Ala Ala Thr His Val Gln Glu Phe Trp Asn Asp Val Arg 
1               5                   10                  15      


Asp Gly Asn Ser Arg Val Gly Lys Leu Ser Arg Val Asp Pro Gly Arg 
            20                  25                  30          


Ala Gly Val His Gly Ala Gly Glu Leu Arg Asp Phe Asp His Arg Lys 
        35                  40                  45              


Phe Leu Pro Glu Leu Ser Glu Lys Phe Ala Gly Arg Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Glu Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Leu Gly Ser Asp Asp Leu Asp Pro Arg Lys Ile Ser Leu Ile Ala Ser 
                85                  90                  95      


Thr Ser Arg Gly Pro Leu Glu Trp Val Asn Glu Ala Leu Arg Gly Asp 
            100                 105                 110         


Asp Asp Gly Ala Gln Glu Ala Ala Gly Ala Asp His Phe Gly Asp Ser 
        115                 120                 125             


Gly Ala Leu Leu Arg Gly Leu Pro Gly Ala Pro Ala Ser Leu Ser Ala 
    130                 135                 140                 


Leu Tyr Gly Asp Val Arg Gly Phe Val Thr Ser Leu Ser Ser Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala 
                165                 170                 175     


Gly Ile Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr 
            180                 185                 190         


Pro Leu Val Phe Gln Thr Phe Arg Ala Met Gly Asn Arg Val Leu Ser 
        195                 200                 205             


Thr Glu Ser Asp Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp 
    210                 215                 220                 


Arg Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Phe Ala Arg Phe 
                245                 250                 255     


Leu Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp 
            260                 265                 270         


Met Ser Gly Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Glu Asp 
        275                 280                 285             


Ala Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu 
305                 310                 315                 320 


Tyr Glu Gly Arg Pro Lys Ser Ala Trp Pro Pro Leu Ser Ser Val Lys 
                325                 330                 335     


Pro Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala 
            340                 345                 350         


Ala Thr Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn 
        355                 360                 365             


Tyr Ala Gly Gly Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Ala Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  232
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamA polypeptide

<400>  232

Met Leu Pro Ala Ala Thr His Val Gln Glu Phe Trp Asn Asp Val Arg 
1               5                   10                  15      


Asp Gly Asn Ser Arg Val Gly Lys Leu Ser Arg Val Asp Pro Gly Arg 
            20                  25                  30          


Ala Gly Val His Gly Ala Gly Glu Leu Arg Asp Phe Asp His Arg Lys 
        35                  40                  45              


Phe Leu Pro Glu Leu Ser Glu Lys Phe Ala Gly Arg Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Glu Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Leu Gly Ser Asp Asp Leu Asp Pro Arg Lys Ile Ser Leu Ile Ala Ser 
                85                  90                  95      


Thr Ser Arg Gly Pro Leu Glu Trp Val Asn Glu Ala Leu Arg Gly Asp 
            100                 105                 110         


Asp Asp Gly Ala Gln Glu Ala Ala Gly Ala Asp His Phe Gly Asp Ser 
        115                 120                 125             


Gly Ala Leu Leu Arg Gly Leu Pro Gly Ala Pro Ala Ser Leu Ser Ala 
    130                 135                 140                 


Leu Tyr Gly Asp Val Arg Gly Phe Val Thr Ser Leu Ser Ser Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Gly Phe Ala Ala Asp Leu Ile Arg Ala 
                165                 170                 175     


Gly Ile Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr 
            180                 185                 190         


Pro Leu Val Phe Gln Thr Phe Arg Ala Met Gly Asn Arg Val Leu Ser 
        195                 200                 205             


Thr Glu Ser Asp Asp Pro Arg Arg Ala Ile Arg Pro Tyr Thr Arg Asp 
    210                 215                 220                 


Arg Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Phe Ala Arg Phe 
                245                 250                 255     


Leu Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp 
            260                 265                 270         


Met Ser Gly Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Glu Asp 
        275                 280                 285             


Ala Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Val Ala Glu Ser Arg Met Leu Gly Ala Leu 
305                 310                 315                 320 


Tyr Glu Gly Arg Pro Lys Ser Ala Trp Pro Pro Leu Ser Ser Val Lys 
                325                 330                 335     


Pro Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala 
            340                 345                 350         


Ala Thr Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn 
        355                 360                 365             


Tyr Ala Gly Gly Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Ala Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  233
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamA polypeptide

<400>  233

Met Leu Pro Gly Ala Thr His Val Asn Glu Phe Trp Gln Asp Val Arg 
1               5                   10                  15      


Glu Gly Asn Ser Arg Ile Gly Arg Leu Thr Lys Val Asp Pro Gly Arg 
            20                  25                  30          


Ala Gly Val His Ala Ala Gly Asp Leu Arg Asp Phe Asp His Arg Lys 
        35                  40                  45              


Phe Leu Pro Glu Leu Ser Glu Arg Phe Ala Ala Arg Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Glu Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Leu Gly Ser Glu Asp Ile Asp Pro Arg Arg Val Ser Leu Ile Ala Ser 
                85                  90                  95      


Ser Ser Arg Gly Pro Leu Glu Phe Leu Gln Glu Ala Leu Arg Gly Asp 
            100                 105                 110         


Asp Asp Gly Ala Gln Glu Ala Gly Gly Ala Asp His Phe Gly Glu Ser 
        115                 120                 125             


Gly Ala Met Leu Arg Gly Ile Pro Gly Ala Pro Ala Thr Val Ser Ala 
    130                 135                 140                 


Ile Tyr Gly Asp Val Arg Gly Phe Val Thr Thr Leu Ser Ser Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Ala Phe Ala Ala Asp Leu Ile Arg Ala 
                165                 170                 175     


Gly Ile Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Ser 
            180                 185                 190         


Pro Leu Val Phe Gln Ser Phe Arg Ala Val Gly Asn Arg Met Leu Ser 
        195                 200                 205             


Thr Asp Ser Asp Asp Pro Arg Arg Ala Ile Lys Pro Tyr Thr Arg Asp 
    210                 215                 220                 


Arg Asp Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Arg Ala Arg Gly Ala Gly Gly Trp Ala Arg Phe 
                245                 250                 255     


Leu Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp 
            260                 265                 270         


Met Ser Gly Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Asp Asp 
        275                 280                 285             


Ala Gly Arg Ser Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Val Ala Glu Ser Lys Met Leu Gly Ala Val 
305                 310                 315                 320 


Tyr Glu Gly Arg Pro Arg Ser Ala Trp Pro Pro Leu Ser Ser Val Lys 
                325                 330                 335     


Pro Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Val Asn Ala Ala 
            340                 345                 350         


Ala Thr Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Ser Ala Asn 
        355                 360                 365             


Phe Ala Ala Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Gly Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  234
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamA polypeptide

<400>  234

Met Leu Pro Gly Ala Thr His Val Asn Glu Phe Trp Gln Asp Val Arg 
1               5                   10                  15      


Asp Gly Asn Ser Arg Val Gly Lys Leu Thr Arg Val Asp Pro Gly Arg 
            20                  25                  30          


Ala Ala Val His Ala Ala Gly Glu Leu Arg Asp Phe Asp His Lys Lys 
        35                  40                  45              


Phe Leu Pro Glu Leu Ser Glu Lys Phe Ala Gly Arg Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Asp Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Leu Gly Ser Glu Asp Ile Asp Pro Lys Arg Ile Ser Leu Ile Ala Ser 
                85                  90                  95      


Ser Ser Arg Gly Pro Leu Glu Trp Leu Asn Glu Gly Leu Lys Gly Asp 
            100                 105                 110         


Asp Glu Gly Ala Gln Glu Ala Gly Gly Ala Asp His Phe Gly Asp Ser 
        115                 120                 125             


Gly Ala Val Leu Arg Gly Ile Pro Gly Ala Pro Ala Ser Ile Ser Ala 
    130                 135                 140                 


Ile Phe Gly Asp Val Lys Gly Phe Val Thr Thr Leu Ser Thr Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Ala Phe Ala Ala Asp Leu Ile Lys Ala 
                165                 170                 175     


Gly Ile Ala Asp Gly Val Val Val Val Gly Tyr Glu Phe Pro Leu Thr 
            180                 185                 190         


Pro Leu Val Phe Gln Ser Tyr Lys Gly Met Gly Asn Arg Val Leu Ser 
        195                 200                 205             


Ser Glu Ser Asp Asp Pro Arg Arg Ala Leu Arg Pro Tyr Thr Arg Glu 
    210                 215                 220                 


Arg Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Lys Ala Arg Gly Ala Gly Gly Tyr Ala Arg Phe 
                245                 250                 255     


Val Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Ala Val Asp 
            260                 265                 270         


Met Ser Ala Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Glu Glu 
        275                 280                 285             


Ala Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Val Ala Glu Thr Arg Met Leu Gly Ala Leu 
305                 310                 315                 320 


Tyr Glu Ala Arg Pro Lys Ser Gly Trp Pro Pro Leu Ser Ser Val Lys 
                325                 330                 335     


Pro Met Tyr Gly His Leu Val Gly Ala Ala Ala Leu Val Asn Ala Ala 
            340                 345                 350         


Ala Ser Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Ser Ala Asn 
        355                 360                 365             


Tyr Ala Gly Ala Val Pro Asp Pro Glu Cys Asp His Asp His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Ala Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  235
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamA polypeptide

<400>  235

Met Leu Pro Gly Ala Thr His Val Gln Glu Phe Trp Gln Asp Val Arg 
1               5                   10                  15      


Asp Gly Asn Ser Arg Ile Gly Arg Leu Thr Arg Leu Glu Pro Ala Lys 
            20                  25                  30          


Ala Gly Ile His Ala Ala Gly Asp Leu Lys Asp Phe Asp His Arg Arg 
        35                  40                  45              


Phe Leu Pro Asp Leu Ser Glu Lys Phe Ala Gly Lys Tyr Thr Arg Asp 
    50                  55                  60                  


Ala Leu Val Thr Met Ser Ala Val Glu Glu Ala Arg Arg Asp Ala Gly 
65                  70                  75                  80  


Ile Ala Ser Asp Asp Leu Asp Pro Arg Lys Ile Ser Leu Ile Ala Ser 
                85                  90                  95      


Thr Ser Arg Gly Pro Leu Glu Trp Leu Asn Glu Ala Val Arg Gly Asp 
            100                 105                 110         


Glu Asp Gly Ala Gln Asp Ala Gly Gly Gly Asp His Phe Gly Asp Ser 
        115                 120                 125             


Gly Ala Met Leu Arg Gly Met Pro Gly Ala Pro Ala Thr Leu Ser Ala 
    130                 135                 140                 


Ile Trp Gly Asp Val Arg Gly Phe Val Thr Thr Leu Ser Thr Ala Cys 
145                 150                 155                 160 


Val Gly Gly His His Ala Ile Gly Phe Ala Ala Glu Leu Ile Arg Ala 
                165                 170                 175     


Gly Ile Ala Asp Ala Val Val Val Val Gly Tyr Glu Phe Pro Leu Ser 
            180                 185                 190         


Pro Leu Val Phe Gln Ser Phe Arg Ala Leu Gly Asn Arg Ile Leu Ser 
        195                 200                 205             


Thr Glu Ser Asp Glu Pro Arg Arg Ala Ile Arg Pro Tyr Thr Lys Asp 
    210                 215                 220                 


Arg Glu Gly Phe Ala Phe Gly Glu Gly Ala Val Ala Leu Cys Leu Glu 
225                 230                 235                 240 


Arg Glu Ser His Ala Arg Ala Arg Gly Ala Ala Gly Tyr Ala Arg Phe 
                245                 250                 255     


Leu Ser His Arg Ala Leu Asn Glu Ala Thr His Pro Phe Gly Met Asp 
            260                 265                 270         


Met Thr Gly Gln Val Thr Ala Ser Ala Val Ala Gly Ala Leu Asp Asp 
        275                 280                 285             


Ala Gly Arg Thr Pro Arg Asp Val Asp Trp Phe Cys Ala His Gly Thr 
    290                 295                 300                 


Ala Thr Pro Lys Asn Asp Leu Ala Glu Ser Lys Met Leu Ala Ala Leu 
305                 310                 315                 320 


Tyr Glu Ala Arg Pro Arg Thr Ala Trp Pro Pro Leu Ser Ser Ile Lys 
                325                 330                 335     


Pro Val Tyr Gly His Leu Leu Gly Ala Ala Ala Leu Ile Asn Ala Ala 
            340                 345                 350         


Ala Thr Ala Leu Ala Leu His His Gln Cys Leu Cys Ser Thr Ala Asn 
        355                 360                 365             


Tyr Ala Gly Ala Val Pro Asp Pro Glu Cys Glu His Glu His Val Ala 
    370                 375                 380                 


Glu Gly Pro Arg Ala Thr Arg Ala Asp Leu Ala Val Ser Leu Ala Phe 
385                 390                 395                 400 


Ala Ile Gly Ser Gln Thr Ser Val Leu Ala Leu Gly Ala Ala 
                405                 410                 


<210>  236
<211>  1860
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  236
gtgaccggtg gccggccccc gcggaccgaa cccctgaagg agaccatgac cacgcacagc       60

ggcaccgcgc cccgccccgt cgtcgtcccc gatgtcgact ccctggtgtc ccggtacgtg      120

accccgggca tgcatctgca cctggcgatg accatggcgc ggcccaacgc catggtctac      180

gcgctggcgc ggcagttcgc gggccggggc gagttcaccg tcagcacgtc ggcgacgcac      240

acggcgatgc acgcgctgac catgtccggc gccgtcaagc acctgatcac ctgcttcctc      300

ggcgacacct accccacgcc gcggcccaat ccgctctacc gcgacctggc ccgcggcacc      360

ccgttcacct gcgagctgtg gtccctgctc agcttcacgc agcgcctgat ggccggggcc      420

accggactgc cgtacgccgt gacgtcctcc ctcgtcggca gcgacctgga gcgggggctc      480

accgacggcg gccgcgacgg gcggccggaa gcggcgggcc agggggcgcg gctcggcccg      540

aagttcctgc ggatgaccgc cccggcggcc ggggaccgcc cgttcgccct cgtcgagcgg      600

ctgcgaccgg acctcaccct ggtgcacggc gcctgcgcgg accggcgcgg caacgtcgtg      660

ctcgtgccgc ccgcgggcga gggcgcctgg gccgcgtacg ccgccgacaa gggggtgatc      720

gcctcggtgg aacgcatcgt gccggacgac ttcgtcgacg agcacccgga gctggtcgtc      780

gtccccgggc agcgcgtgct cgccctgtgc gaggcgccgc tcggcgcgca cccgcagtcg      840

ctgcgcggcc tcggcaccgg cgacgagacc ggcgacgtgg tgggctaccg cgacgactac      900

gccttcctca ccgagctggt cgagcggctt tccaccgagg acggcgccaa ggagtggtac      960

cgcgagtggg tggaggagcc cgccgggcac gcgcagtacg tgcgcaaact gggcagcgcc     1020

cggcgcgccg aactcaccct cgccgcccgg ccgctcaccg cgcgcgcgac cacggctccg     1080

ccgcccctcc ccgctgccgc ggcgacggtc gccgagcccg tgacgcgcca ggagcggacc     1140

gtcgtcctcg gggcccgcgc catcgtcgaa cgggtcacga gcgacggcta cgacaccctg     1200

ctcgccggca tcggcgtgtc ccacctggcg gcctggctgg ccgcggcgct cctgcgcggg     1260

cggggcatcc aggtgccggt ctgcgccgaa ctcggcttct acggcatgga ccccgagccc     1320

ggtgacgtct tcctgttcag ccagctgcac gccacccgct cccagcagct cgccggcatc     1380

ccggagatcc tcggcggcat ggtgtcggcg aacccacgct gcctcggtgt cctcgcggcc     1440

ggcgaggtcg acgcggacgg caacgtcaac accagcctgc tggccgacgg ccggtggctg     1500

accggctccg gcggcgccaa cgacatcgcc acgagcaccg attgcctggt gctgtccacg     1560

gcatccccgc gcaagttcgt cgagcgggtc gcctacgtca ccagtcccgg tgccagggtg     1620

cgcgaagtgg tcagccactt cgggcggttc cggcgcgagg agggcggggg cacaccgggg     1680

cccttccgcc tcgccacctg gctggcgggc gccgacgacg gcccggcctc tcccgaggag     1740

gccgtggcgt cgctgacccg gtggtccgtg agcaccgcgg gctgcaccgc ggaaccggac     1800

gtcaccgagg cggagatcgc ctggcttcgc agtctcgatc cgcagggttt ctacaggtga     1860


<210>  237
<211>  619
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  237

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Arg Pro Val Val Val Pro Asp Val 
            20                  25                  30          


Asp Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met His Leu His Leu 
        35                  40                  45              


Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr Ala Leu Ala Arg 
    50                  55                  60                  


Gln Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr Ser Ala Thr His 
65                  70                  75                  80  


Thr Ala Met His Ala Leu Thr Met Ser Gly Ala Val Lys His Leu Ile 
                85                  90                  95      


Thr Cys Phe Leu Gly Asp Thr Tyr Pro Thr Pro Arg Pro Asn Pro Leu 
            100                 105                 110         


Tyr Arg Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Trp Ser 
        115                 120                 125             


Leu Leu Ser Phe Thr Gln Arg Leu Met Ala Gly Ala Thr Gly Leu Pro 
    130                 135                 140                 


Tyr Ala Val Thr Ser Ser Leu Val Gly Ser Asp Leu Glu Arg Gly Leu 
145                 150                 155                 160 


Thr Asp Gly Gly Arg Asp Gly Arg Pro Glu Ala Ala Gly Gln Gly Ala 
                165                 170                 175     


Arg Leu Gly Pro Lys Phe Leu Arg Met Thr Ala Pro Ala Ala Gly Asp 
            180                 185                 190         


Arg Pro Phe Ala Leu Val Glu Arg Leu Arg Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Arg Arg Gly Asn Val Val Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Asp Glu His Pro 
                245                 250                 255     


Glu Leu Val Val Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Ala 
            260                 265                 270         


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Gly Leu Gly Thr Gly Asp 
        275                 280                 285             


Glu Thr Gly Asp Val Val Gly Tyr Arg Asp Asp Tyr Ala Phe Leu Thr 
    290                 295                 300                 


Glu Leu Val Glu Arg Leu Ser Thr Glu Asp Gly Ala Lys Glu Trp Tyr 
305                 310                 315                 320 


Arg Glu Trp Val Glu Glu Pro Ala Gly His Ala Gln Tyr Val Arg Lys 
                325                 330                 335     


Leu Gly Ser Ala Arg Arg Ala Glu Leu Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Thr Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Val Ala Glu Pro Val Thr Arg Gln Glu Arg Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Glu Arg Val Thr Ser Asp Gly Tyr Asp Thr Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp Leu Ala Ala Ala 
                405                 410                 415     


Leu Leu Arg Gly Arg Gly Ile Gln Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Leu Ala Gly Ile Pro Glu Ile Leu 
    450                 455                 460                 


Gly Gly Met Val Ser Ala Asn Pro Arg Cys Leu Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser Leu Leu Ala Asp 
                485                 490                 495     


Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Leu Ser Thr Ala Ser Pro Arg Lys Phe Val Glu 
        515                 520                 525             


Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Glu Glu Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Arg Leu Ala Thr Trp Leu Ala Gly Ala Asp Asp Gly Pro Ala 
                565                 570                 575     


Ser Pro Glu Glu Ala Val Ala Ser Leu Thr Arg Trp Ser Val Ser Thr 
            580                 585                 590         


Ala Gly Cys Thr Ala Glu Pro Asp Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  238
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamB polypeptide

<400>  238

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Lys Pro Val Ile Val Pro Asp Val 
            20                  25                  30          


Asp Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met His Leu His Leu 
        35                  40                  45              


Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr Ala Leu Ala Arg 
    50                  55                  60                  


Gln Phe Ala Gly Arg Gly Glu Phe Thr Ile Ser Ser Ser Ala Thr His 
65                  70                  75                  80  


Thr Ala Leu His Ala Leu Thr Met Ser Gly Ala Val Lys His Leu Ile 
                85                  90                  95      


Ser Cys Phe Val Gly Asp Thr Tyr Pro Thr Pro Arg Pro Asn Pro Leu 
            100                 105                 110         


Tyr Arg Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Trp Ser 
        115                 120                 125             


Leu Leu Ser Phe Thr Gln Arg Leu Met Ala Gly Ala Thr Gly Leu Pro 
    130                 135                 140                 


Tyr Ala Val Thr Ser Ser Leu Val Gly Ser Asp Leu Glu Arg Gly Leu 
145                 150                 155                 160 


Thr Glu Gly Gly Arg Asp Gly Arg Pro Glu Ala Ala Gly Gln Gly Gly 
                165                 170                 175     


Lys Leu Gly Pro Lys Phe Leu Arg Met Thr Ala Pro Ala Ala Gly Asp 
            180                 185                 190         


Arg Pro Tyr Ala Leu Val Glu Arg Leu Arg Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Arg Arg Gly Asn Val Val Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Asp Glu His Pro 
                245                 250                 255     


Glu Leu Val Val Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Ala 
            260                 265                 270         


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Gly Leu Gly Thr Gly Asp 
        275                 280                 285             


Glu Thr Gly Asp Val Val Gly Tyr Arg Asp Asp Tyr Ala Phe Leu Thr 
    290                 295                 300                 


Asp Leu Val Glu Arg Leu Ser Thr Glu Asp Gly Ala Lys Glu Phe Tyr 
305                 310                 315                 320 


Arg Glu Trp Val Glu Asp Pro Ala Gly His Ala Gln Tyr Leu Arg Lys 
                325                 330                 335     


Leu Gly Ser Ala Arg Arg Ala Asp Ile Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Thr Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Val Ala Glu Pro Val Ser Arg Gln Glu Lys Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Glu Arg Val Thr Ser Asp Gly Tyr Asp Thr Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp Leu Ala Ala Ala 
                405                 410                 415     


Ile Val Arg Gly Arg Gly Ile Asn Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Met Ala Gly Ile Pro Asp Ile Leu 
    450                 455                 460                 


Ala Gly Met Val Ser Ala Asn Pro Arg Cys Leu Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser Met Leu Ala Asp 
                485                 490                 495     


Gly Arg Trp Val Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Val Ser Thr Ala Ser Pro Arg Lys Phe Val Glu 
        515                 520                 525             


Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Glu Asp Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Arg Leu Ala Thr Trp Leu Ala Gly Ala Asp Asp Gly Pro Ala 
                565                 570                 575     


Ser Pro Glu Glu Ala Val Ala Ser Leu Thr Arg Trp Ser Val Ser Ser 
            580                 585                 590         


Ala Gly Cys Thr Ala Glu Pro Glu Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  239
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamB polypeptide

<400>  239

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Arg Pro Val Val Val Pro Asp Val 
            20                  25                  30          


Asp Ser Leu Val Ser Arg Tyr Val Thr Pro Gly Met His Leu His Val 
        35                  40                  45              


Ala Met Thr Met Ala Arg Pro Asn Ala Met Val Tyr Ala Leu Gly Arg 
    50                  55                  60                  


Asn Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Ser Ser Ala Thr His 
65                  70                  75                  80  


Thr Ala Leu His Ala Leu Thr Met Ser Gly Ala Val Lys His Val Ile 
                85                  90                  95      


Thr Cys Phe Leu Gly Asp Ser Tyr Pro Thr Pro Arg Pro Asn Pro Leu 
            100                 105                 110         


Phe Arg Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Trp Ser 
        115                 120                 125             


Leu Leu Thr Phe Thr Gln Arg Leu Met Ala Gly Ala Thr Gly Leu Pro 
    130                 135                 140                 


Tyr Ala Val Thr Ser Ser Leu Leu Gly Ser Asp Leu Glu Arg Gly Leu 
145                 150                 155                 160 


Thr Asp Gly Gly Arg Asp Gly Lys Pro Asp Gly Ala Gly Gln Gly Gly 
                165                 170                 175     


Arg Leu Gly Pro Lys Phe Leu Arg Met Thr Ala Pro Ala Ala Ala Asp 
            180                 185                 190         


Arg Pro Tyr Ala Leu Val Glu Arg Leu Arg Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Arg Arg Gly Asn Val Val Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Asp Glu His Pro 
                245                 250                 255     


Glu Leu Val Val Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Ala 
            260                 265                 270         


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Gly Leu Gly Thr Ala Asp 
        275                 280                 285             


Glu Thr Gly Asp Val Val Gly Tyr Arg Asp Asp Tyr Ala Phe Leu Thr 
    290                 295                 300                 


Glu Leu Val Glu Arg Ile Ser Ser Glu Asp Gly Ala Lys Glu Trp Tyr 
305                 310                 315                 320 


Arg Glu Trp Leu Glu Glu Pro Ala Gly His Ala Gln Tyr Val Arg Lys 
                325                 330                 335     


Val Gly Ser Ala Arg Arg Ala Asp Leu Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Thr Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Leu Ala Glu Pro Val Thr Arg Gln Glu Arg Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Asp Arg Val Thr Ser Asp Gly Tyr Asp Thr Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp Leu Ala Ala Ala 
                405                 410                 415     


Leu Leu Arg Gly Arg Gly Ile Gln Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Ile Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Ile Ala Gly Ile Pro Glu Ile Leu 
    450                 455                 460                 


Gly Gly Met Val Ser Ala Asn Pro Arg Cys Leu Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Gly Asp Gly Asn Val Asn Thr Ser Met Leu Ala Asp 
                485                 490                 495     


Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Leu Ser Thr Ala Thr Pro Arg Lys Phe Val Glu 
        515                 520                 525             


Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Asp Glu Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Arg Leu Ala Thr Trp Leu Ala Gly Gly Asp Asp Gly Pro Ala 
                565                 570                 575     


Ser Pro Glu Glu Ala Val Ala Ser Leu Thr Arg Trp Ser Val Ser Thr 
            580                 585                 590         


Ala Gly Cys Thr Ala Glu Pro Asp Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Leu Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  240
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamB polypeptide

<400>  240

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Arg Pro Val Val Ile Pro Asp Val 
            20                  25                  30          


Glu Ser Leu Val Ser Arg Phe Val Thr Pro Gly Met His Leu His Val 
        35                  40                  45              


Ala Met Thr Leu Ala Arg Pro Asn Ala Met Val Tyr Ala Leu Ala Lys 
    50                  55                  60                  


Gln Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr Ser Ala Thr His 
65                  70                  75                  80  


Thr Ala Met His Ala Leu Thr Met Ser Gly Ala Val Arg His Ile Ile 
                85                  90                  95      


Thr Cys Phe Leu Gly Asp Thr Trp Pro Thr Pro Arg Pro Asn Pro Leu 
            100                 105                 110         


Phe Arg Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Tyr Ser 
        115                 120                 125             


Leu Leu Thr Phe Thr Gln Arg Leu Met Ala Gly Ala Thr Gly Ile Pro 
    130                 135                 140                 


Tyr Ala Val Thr Ser Ser Leu Val Gly Ser Asp Leu Glu Arg Gly Leu 
145                 150                 155                 160 


Thr Asp Gly Gly Arg Asp Gly Arg Pro Glu Ala Gly Gly Gln Gly Ala 
                165                 170                 175     


Arg Leu Gly Pro Lys Phe Val Arg Met Thr Ala Pro Ala Ala Gly Asp 
            180                 185                 190         


Arg Pro Phe Ala Leu Val Glu Arg Leu Arg Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Lys Arg Gly Asn Val Val Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Asp Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Asp Glu His Pro 
                245                 250                 255     


Glu Leu Val Val Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Ala 
            260                 265                 270         


Pro Leu Gly Ala His Pro Gln Ser Val Arg Gly Leu Gly Thr Ala Asp 
        275                 280                 285             


Glu Thr Gly Glu Val Val Gly Tyr Arg Asp Asp Tyr Ala Phe Met Thr 
    290                 295                 300                 


Glu Leu Val Glu Arg Leu Ser Thr Glu Asp Gly Ala Lys Glu Trp Tyr 
305                 310                 315                 320 


Arg Glu Tyr Leu Glu Asp Pro Ala Gly His Ala Gln Tyr Ile Arg Lys 
                325                 330                 335     


Val Gly Ser Ala Arg Arg Ala Glu Ile Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Thr Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Val Ala Glu Pro Val Ser Arg Gln Asp Arg Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Asp Arg Val Thr Ser Asp Gly Tyr Asp Thr Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp Leu Ala Gly Ala 
                405                 410                 415     


Met Leu Arg Gly Arg Gly Val Gln Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Val Ala Gly Ile Pro Glu Ile Leu 
    450                 455                 460                 


Gly Gly Ile Val Ser Ala Asn Pro Arg Cys Ile Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser Met Ile Ala Asp 
                485                 490                 495     


Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Leu Ser Thr Ala Thr Pro Arg Lys Phe Val Glu 
        515                 520                 525             


Lys Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Glu Glu Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Arg Leu Ala Thr Trp Leu Ala Gly Ala Asp Asp Gly Pro Ala 
                565                 570                 575     


Thr Pro Glu Glu Ala Val Ala Ser Leu Thr Arg Phe Ser Val Ser Ser 
            580                 585                 590         


Ala Gly Cys Ser Ala Glu Pro Asp Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Ile Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  241
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamB polypeptide

<400>  241

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Lys Pro Val Val Val Pro Asp Leu 
            20                  25                  30          


Asp Ser Leu Val Ser Arg Phe Val Thr Pro Gly Met His Leu His Ile 
        35                  40                  45              


Ala Met Ser Met Ala Arg Pro Asn Ala Met Val Phe Ala Leu Ala Arg 
    50                  55                  60                  


Gln Phe Ala Gly Arg Gly Glu Phe Thr Val Ser Thr Ser Ala Thr His 
65                  70                  75                  80  


Thr Ala Ile His Ala Leu Thr Met Ser Gly Ala Val Lys His Val Ile 
                85                  90                  95      


Ser Cys Phe Val Gly Asp Ser Tyr Pro Thr Pro Arg Pro Asn Pro Val 
            100                 105                 110         


Tyr Lys Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Trp Ser 
        115                 120                 125             


Leu Leu Thr Phe Thr Gln Arg Leu Met Ala Gly Ala Ser Gly Ile Pro 
    130                 135                 140                 


Tyr Ala Val Thr Ser Thr Leu Leu Gly Ser Asp Leu Asp Arg Gly Leu 
145                 150                 155                 160 


Thr Asp Gly Gly Arg Asp Gly Arg Pro Glu Gly Ala Gly Gln Gly Ala 
                165                 170                 175     


Lys Met Ala Pro Lys Phe Leu Arg Val Thr Ala Pro Ala Ala Gly Asp 
            180                 185                 190         


Arg Pro Phe Ala Met Val Glu Arg Leu Arg Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Arg Arg Gly Asn Val Ile Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Ala Gly Trp Ala Ala Tyr Ala Ala Glu Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Glu Glu His Pro 
                245                 250                 255     


Glu Leu Val Leu Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Ala 
            260                 265                 270         


Pro Leu Gly Gly His Pro Asn Thr Leu Arg Gly Leu Gly Thr Gly Asp 
        275                 280                 285             


Glu Ser Gly Glu Val Val Gly Tyr Arg Asp Asp Tyr Ala Phe Leu Thr 
    290                 295                 300                 


Glu Leu Val Glu Arg Val Ser Thr Glu Glu Gly Ala Lys Glu Phe Tyr 
305                 310                 315                 320 


Arg Glu Trp Ile Glu Glu Pro Ala Gly His Ala Gln Tyr Val Arg Lys 
                325                 330                 335     


Val Gly Ser Ala Lys Arg Gly Glu Leu Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Ser Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Leu Ala Glu Pro Val Thr Arg Gln Glu Arg Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Glu Arg Val Thr Ser Asp Gly Tyr Glu Ser Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Ala Trp Leu Ala Ala Ala 
                405                 410                 415     


Ile Leu Arg Gly Arg Gly Ile Gln Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Ile Ala Gly Met Pro Asp Ile Leu 
    450                 455                 460                 


Gly Gly Ile Val Ser Ala Asn Pro Arg Cys Leu Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser Leu Leu Ala Asp 
                485                 490                 495     


Gly Arg Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Leu Ser Thr Ala Thr Pro Lys Lys Phe Val Asp 
        515                 520                 525             


Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Glu Asp Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Lys Leu Ala Thr Trp Leu Ala Gly Ala Asp Asp Ala Pro Gly 
                565                 570                 575     


Ser Pro Glu Glu Ala Val Ala Ser Ile Thr Arg Trp Ser Val Ser Ser 
            580                 585                 590         


Ala Gly Cys Thr Ala Glu Pro Asp Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Ile Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  242
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamB polypeptide

<400>  242

Met Thr Gly Gly Arg Pro Pro Arg Thr Glu Pro Leu Lys Glu Thr Met 
1               5                   10                  15      


Thr Thr His Ser Gly Thr Ala Pro Arg Pro Val Val Ile Pro Asp Val 
            20                  25                  30          


Asp Ser Leu Val Ser Lys Tyr Val Thr Pro Gly Met His Leu His Leu 
        35                  40                  45              


Ala Met Thr Val Ala Arg Pro Asn Ala Met Val Tyr Ala Leu Ala Arg 
    50                  55                  60                  


Gln Phe Ala Gly Arg Gly Glu Phe Thr Leu Ser Ser Ser Ala Ser His 
65                  70                  75                  80  


Ser Ala Met His Ala Leu Thr Val Thr Gly Ala Val Arg His Leu Ile 
                85                  90                  95      


Ser Cys Phe Leu Gly Asp Ser Tyr Pro Thr Pro Arg Pro Asn Pro Val 
            100                 105                 110         


Tyr Arg Asp Leu Ala Arg Gly Thr Pro Phe Thr Cys Glu Leu Trp Ser 
        115                 120                 125             


Leu Leu Ser Phe Thr Asn Arg Leu Met Ala Gly Ala Thr Gly Ile Pro 
    130                 135                 140                 


Tyr Ala Ile Thr Ser Thr Leu Leu Gly Ser Asp Leu Glu Arg Gly Leu 
145                 150                 155                 160 


Thr Glu Gly Ala Arg Asp Gly Arg Pro Glu Ala Ala Gly Gln Gly Gly 
                165                 170                 175     


Lys Ile Gly Pro Lys Phe Leu Arg Ile Thr Ala Pro Ala Ala Gly Asp 
            180                 185                 190         


Arg Pro Phe Ala Met Val Glu Arg Leu Lys Pro Asp Leu Thr Leu Val 
        195                 200                 205             


His Gly Ala Cys Ala Asp Arg Lys Gly Asn Val Leu Leu Val Pro Pro 
    210                 215                 220                 


Ala Gly Glu Ala Ala Trp Ala Ala Tyr Ala Ala Asp Lys Gly Val Ile 
225                 230                 235                 240 


Ala Ser Val Glu Arg Ile Val Pro Asp Asp Phe Val Asp Glu His Pro 
                245                 250                 255     


Glu Met Val Val Val Pro Gly Gln Arg Val Leu Ala Leu Cys Glu Gly 
            260                 265                 270         


Pro Leu Gly Ala His Pro Gln Ser Val Arg Gly Leu Gly Thr Gly Asp 
        275                 280                 285             


Glu Thr Gly Glu Val Val Gly Tyr Arg Asp Asp Tyr Ala Tyr Met Thr 
    290                 295                 300                 


Asp Leu Val Glu Arg Leu Ser Ser Glu Glu Gly Ala Lys Glu Tyr Tyr 
305                 310                 315                 320 


Arg Glu Trp Leu Glu Glu Pro Ala Gly His Ala Gln Phe Val Arg Lys 
                325                 330                 335     


Leu Gly Ser Ala Arg Arg Ala Glu Leu Thr Leu Ala Ala Arg Pro Leu 
            340                 345                 350         


Thr Ala Arg Ala Thr Thr Ala Pro Pro Pro Leu Pro Ala Ala Ala Ala 
        355                 360                 365             


Thr Val Ala Glu Pro Val Ser Arg Gln Asp Arg Thr Val Val Leu Gly 
    370                 375                 380                 


Ala Arg Ala Ile Val Asp Arg Val Thr Ser Asp Gly Tyr Asp Thr Leu 
385                 390                 395                 400 


Leu Ala Gly Ile Gly Val Ser His Leu Ala Gly Trp Leu Ala Ala Ala 
                405                 410                 415     


Leu Leu Arg Gly Arg Gly Met Asn Val Pro Val Cys Ala Glu Leu Gly 
            420                 425                 430         


Phe Tyr Gly Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln 
        435                 440                 445             


Leu His Ala Thr Arg Ser Gln Gln Val Ala Gly Ile Pro Asp Ile Leu 
    450                 455                 460                 


Gly Gly Ile Val Ser Ala Asn Pro Arg Cys Val Gly Val Leu Ala Ala 
465                 470                 475                 480 


Gly Glu Val Asp Ala Asp Gly Asn Val Asn Thr Ser Leu Ile Ala Glu 
                485                 490                 495     


Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser 
            500                 505                 510         


Thr Asp Cys Leu Val Val Ser Thr Ala Ser Pro Arg Lys Phe Val Glu 
        515                 520                 525             


Arg Val Ala Tyr Val Thr Ser Pro Gly Ala Arg Val Arg Glu Val Val 
    530                 535                 540                 


Ser His Phe Gly Arg Phe Arg Arg Asp Glu Gly Gly Gly Thr Pro Gly 
545                 550                 555                 560 


Pro Phe Lys Leu Ala Thr Trp Leu Ala Gly Ala Asp Asp Gly Pro Gly 
                565                 570                 575     


Ser Pro Glu Glu Ala Val Ala Ser Leu Thr Arg Trp Ser Val Thr Ser 
            580                 585                 590         


Gly Gly Cys Thr Ala Glu Pro Asp Val Thr Glu Ala Glu Ile Ala Trp 
        595                 600                 605             


Leu Arg Ser Ile Asp Pro Gln Gly Phe Tyr Arg 
    610                 615                 


<210>  243
<211>  960
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  243
gtgagcggtg gcatctggat gggccgcggc ctgtccttca ggggctttgg ccgctacttc       60

ccacggcaca gcgaggagat tcccgcggac ctgccggagg cgcccgagat ggaggcggcg      120

gtcctcggac ccgacctcgg cgtggaacgg cggcatctgt ccgacgacac ggagaccgtg      180

ccgttcatgg ccgtcgaggc cggacggcac gcgctgcgca acgccggcct ggaggccgac      240

gacctcgacc tggtggtctt ctcgtcctgg tcacaacgcc ggtacgcgcc cgaggacgcg      300

cccaggatcg cgatgcggct cggcgccgga cgggccctgg ccttcgacgt ctgcgcggcc      360

tgcgtcggct tcgtgcactc cgtgcagacg gccgccgcga tgctgaccag ccatcagtgg      420

cggcgcgccc tcgtggtctg ttccgaccag ttctcgcggc ggctcaagcc cggccggcgc      480

ggatcgtacg tcggcgggga cggggcgggc gcggcggtcc tggaggcggg gccgccggac      540

gactcccggc tgcgtgactc cgtcgtgctg agctacggcg agcacgcggg cgtctccaag      600

gcccggggca gcgacgggtg gacggtcagc ctgccctcga tcgcgcaggt ggcggcggcg      660

accgcgggcg aggccacgga ccaggtgctg cggcgcaacg gcatgacgat ggccgacgtg      720

gaccggatcg tgccgcatcc gggctcggcg cggatcagcg aggagctggt gcggcgcatc      780

ggcgccgatc ccgaacgggt cctgacgaac ctgcgcacgc gtggccagac gaccagcgcg      840

acgatcccga gcgccctgtc ggagttcacc gagtccggcg aactgcgcaa gggcgacgtg      900

atcctgtcgc ccgcggccgg cgcgggctgg ttctccggag ccctgctgta ccagctgtga      960


<210>  244
<211>  319
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  244

Met Ser Gly Gly Ile Trp Met Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly Arg Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Asp Asp Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Met Leu Thr Ser His Gln Trp Arg Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Ala 
                165                 170                 175     


Gly Pro Pro Asp Asp Ser Arg Leu Arg Asp Ser Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Gly Val Ser Lys Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ala Gln Val Ala Ala Ala Thr Ala Gly Glu 
    210                 215                 220                 


Ala Thr Asp Gln Val Leu Arg Arg Asn Gly Met Thr Met Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Leu 
                245                 250                 255     


Val Arg Arg Ile Gly Ala Asp Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  245
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamD polypeptide

<400>  245

Met Ser Gly Gly Ile Trp Met Ala Arg Gly Val Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly Arg Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Ile Thr Asp Asp Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Lys His Ala Leu Arg Asn Ala Gly Leu Glu Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Met Leu Thr Ser His Gln Trp Arg Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Leu Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Gly 
                165                 170                 175     


Gly Pro Pro Asp Asp Ser Arg Leu Arg Asp Thr Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Gly Val Ser Lys Ala Arg Gly Ser Asp Ala Tyr Thr 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ala Gln Met Ala Ala Ala Thr Ala Ala Glu 
    210                 215                 220                 


Ala Thr Asp Gln Val Leu Lys Lys Asn Gly Leu Thr Met Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Leu 
                245                 250                 255     


Val Arg Lys Ile Gly Ala Asp Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  246
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamD polypeptide

<400>  246

Met Ser Gly Gly Ile Trp Met Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly Arg Tyr Phe Pro Arg His Ser Glu Glu Ile Pro Ala Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Ile Ser Asp Glu Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Asp Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Leu Leu Thr Ser His Gln Trp Arg Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Arg Arg Leu Arg Pro Gly Arg Arg 
145                 150                 155                 160 


Ala Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Ala 
                165                 170                 175     


Gly Pro Pro Asp Glu Thr Arg Leu Arg Asp Ser Val Val Met Ser Tyr 
            180                 185                 190         


Gly Asp His Ala Gly Val Ser Lys Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ala Gln Val Ala Ala Gly Thr Ala Gly Glu 
    210                 215                 220                 


Ala Thr Asp Gln Val Leu Arg Arg Asn Gly Met Thr Ile Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Arg Ile Ser Glu Glu Ile 
                245                 250                 255     


Val Lys Lys Ile Gly Ala Asp Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Asp Ser Gly Glu Leu Arg Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  247
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamD polypeptide

<400>  247

Met Ser Gly Gly Ile Trp Met Gly Arg Gly Leu Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly Arg Tyr Phe Pro Arg His Ser Asp Glu Ile Pro Gly Asp Leu Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Ala Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Ile Ser Asp Asp Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Ile Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Met Arg Leu Gly Ala Ala Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Asn Thr Ala Ala Ala Met Leu Thr Ser His Gln Trp Lys Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Arg Arg Leu Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Ala Thr Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Ala 
                165                 170                 175     


Gly Pro Pro Asp Asp Ser Arg Leu Arg Asp Thr Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Glu His Ala Gly Val Ser Lys Ala Arg Ala Ser Asp Ala Trp Thr 
        195                 200                 205             


Val Thr Leu Pro Ser Ile Ala Gln Val Ala Ala Ala Thr Ala Ala Glu 
    210                 215                 220                 


Ala Thr Glu Gln Ile Leu Arg Arg Asn Gly Met Thr Val Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Arg Leu Ser Glu Glu Ile 
                245                 250                 255     


Leu Arg Arg Ile Gly Ala Asp Pro Glu Arg Val Leu Ser Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Lys Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  248
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamD polypeptide

<400>  248

Met Ser Gly Gly Ile Trp Met Gly Arg Gly Val Ser Phe Arg Gly Phe 
1               5                   10                  15      


Gly Lys Tyr Phe Pro Lys His Ser Asp Asp Ile Pro Ala Asp Val Pro 
            20                  25                  30          


Glu Ala Pro Glu Met Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Lys Arg His Val Ser Asp Asp Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Glu Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Leu Val Val Phe Ser Ser Trp Ser Gln Arg Arg Tyr Ala 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Met Arg Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Met His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Ile Leu Thr Thr His Gln Trp Arg Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Arg Arg Ile Lys Pro Gly Arg Arg 
145                 150                 155                 160 


Gly Ser Phe Ile Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Ala 
                165                 170                 175     


Gly Pro Pro Asp Asp Ser Arg Leu Arg Asp Thr Val Val Leu Ser Tyr 
            180                 185                 190         


Gly Asp His Ala Gly Val Ser Lys Ala Arg Ala Ser Asp Ala Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ala Asn Ile Ala Ala Ala Ser Ala Gly Glu 
    210                 215                 220                 


Ala Thr Glu Gln Val Leu Arg Arg Asn Gly Val Ser Met Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Lys Leu Ser Asp Glu Leu 
                245                 250                 255     


Leu Lys Arg Ile Gly Ala Asp Pro Glu Arg Val Ile Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Glu 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Lys Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Phe Phe Ser Gly Ala Leu Leu Tyr Gln Leu 
305                 310                 315                 


<210>  249
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamD polypeptide

<400>  249

Met Ser Gly Gly Ile Trp Met Gly Arg Gly Leu Ser Phe Arg Gly Tyr 
1               5                   10                  15      


Gly Arg Tyr Tyr Pro Arg His Ser Glu Asp Ile Pro Ala Asp Val Pro 
            20                  25                  30          


Asp Ala Pro Glu Ile Glu Ala Ala Val Leu Gly Pro Asp Leu Gly Val 
        35                  40                  45              


Glu Arg Arg His Leu Ser Asp Asp Thr Glu Thr Val Pro Phe Met Ala 
    50                  55                  60                  


Val Asp Ala Gly Arg His Ala Leu Arg Asn Ala Gly Leu Glu Ala Asp 
65                  70                  75                  80  


Asp Leu Asp Val Val Val Phe Ser Ser Trp Thr Gln Arg Lys Tyr Gly 
                85                  90                  95      


Pro Glu Asp Ala Pro Arg Ile Ala Val Lys Leu Gly Ala Gly Arg Ala 
            100                 105                 110         


Leu Ala Phe Asp Val Cys Ala Ala Cys Val Gly Phe Val His Ser Val 
        115                 120                 125             


Gln Thr Ala Ala Ala Met Leu Ser Ser His Gln Tyr Arg Arg Ala Leu 
    130                 135                 140                 


Val Val Cys Ser Asp Gln Phe Ser Lys Arg Leu Lys Pro Ala Arg Arg 
145                 150                 155                 160 


Gly Ser Tyr Val Gly Gly Asp Gly Ala Gly Ala Ala Val Leu Glu Ala 
                165                 170                 175     


Gly Pro Pro Asp Asp Ser Arg Leu Arg Asp Thr Val Met Leu Thr Phe 
            180                 185                 190         


Gly Asp His Ala Gly Leu Ser Arg Ala Arg Gly Ser Asp Gly Trp Thr 
        195                 200                 205             


Val Ser Leu Pro Ser Ile Ala Gln Val Ala Ala Ala Thr Ala Ala Glu 
    210                 215                 220                 


Ala Thr Asp Gln Val Leu Arg Arg Asn Gly Leu Ser Val Ala Asp Val 
225                 230                 235                 240 


Asp Arg Ile Val Pro His Pro Gly Ser Ala Lys Ile Ser Asp Glu Leu 
                245                 250                 255     


Val Arg Arg Ile Gly Ala Asp Pro Glu Arg Val Leu Thr Asn Leu Arg 
            260                 265                 270         


Thr Arg Gly Gln Thr Thr Ser Ala Thr Ile Pro Ser Ala Leu Ser Asp 
        275                 280                 285             


Phe Thr Glu Ser Gly Glu Leu Arg Lys Gly Asp Val Ile Leu Ser Pro 
    290                 295                 300                 


Ala Ala Gly Ala Gly Trp Phe Ser Gly Ala Met Leu Tyr Gln Leu 
305                 310                 315                 


<210>  250
<211>  1035
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  250
atgtccgaaa cccagtcacc gttcgacggc ggcggcccgc cggtcgtgct cagcggtgtc       60

ggtcactact tcccgggcga gccggtcacc aacgaccact tcgcccgcct gcccggcctc      120

gacgcggacg acgcgtggat acgcaagcac acgggcgtac ggacccgtca ctgggccggt      180

cccgaggagc ggttcgccga gatgggcgtc aaggcggccc ggcaggccct cgacgacgcg      240

ggcctcgaca tctccgacgt ggacgtgatc gtcggcacca gcgcgaccgc gcggccacgc      300

gccaacccgt cctcgatcgg caacaactac atggacatct ccctgccggt gcagcggcag      360

ttgggcgccc gggacgcgtt ctgcttcgac gtgacagccg tggcctgcgc cgggttcctg      420

tacgcgagtg tggtggcccg cgggctgctc gcgacgacgg gcgccaggac cgccctcgtg      480

gtgtgcgccg agagcccgcg cgccatcctg aacttcgggt tcaagaactc cgccctcttc      540

ggcgcgggcg cggcggcggc ggtctggcga cgcggcgagt ccgtgggcgg cggcgccgac      600

ggactgccca cccgcagcgg gttggtcgac gtggtcctgc gcgccgacgg cggctactac      660

gacgccttcg acatcgatga gaacgacaag atggtgatgc gcgggggagt gctctccgag      720

gtcacgcccg acatgctcgt cgaagccggc cagacggtcc tcaaacgcaa tggcctgacc      780

ccggaacaga tttcctggtg cgttccccat caggccaaca ccaatctcct gcacccgatg      840

gcggaccgcc tcggaattcc ccgggaacgc atgctcctga accttccgtg gcgcggcaac      900

acatcgagcg tgggaatgcc gagcgcactc tccgaatacg tacgcgacgg cacggtgaaa      960

cccggcgaac tgctcctcgg cgtgagtatc gggcgtggtc tcagctgggg tgccatggtt     1020

ttccgctacc agtga                                                      1035


<210>  251
<211>  344
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  251

Met Ser Glu Thr Gln Ser Pro Phe Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Gly Leu Asp Ala Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Lys His Thr Gly Val Arg Thr Arg His Trp Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Gln Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro Arg Ala Ile Leu Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Val Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Leu 
        195                 200                 205             


Val Asp Val Val Leu Arg Ala Asp Gly Gly Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Met Val Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Glu Ala Gly Gln Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Thr Pro Glu Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu His Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Leu Asn Leu Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Val Arg Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  252
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamE polypeptide

<400>  252

Met Ser Glu Thr Gln Ser Pro Phe Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Leu Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Gly Leu Asp Ala Glu Asp Ala Trp Ile Arg 
        35                  40                  45              


Lys His Thr Gly Val Arg Ser Arg His Trp Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Lys Gln Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Val Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Gln Asn Tyr Met Glu 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Ile Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Ile Leu Ala Thr Thr Gly Gly Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro Arg Ala Ile Leu Asn Tyr Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Ser Val Gly Gly Gly Ala Asp Gly Leu Pro Thr Lys Ser Gly Leu 
        195                 200                 205             


Val Asp Val Leu Leu Arg Ala Asp Gly Gly Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Leu Val Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Glu Ala Gly Gln Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Val Thr Pro Glu Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu His Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Val Leu Asn Leu Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Asp Tyr Val Arg Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Met Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Trp Gln 
            340                 


<210>  253
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamE polypeptide

<400>  253

Met Ser Glu Thr Gln Ser Pro Phe Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Tyr Phe Pro Ala Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Gly Leu Asp Ala Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Lys His Thr Gly Val Arg Thr Arg His Trp Ala Gly Pro Asp Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Gln Ala Leu Glu Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Leu Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Leu Ser Val Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Met Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro Arg Ala Ile Leu Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Glu Thr Val Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Leu 
        195                 200                 205             


Val Asp Ile Val Leu Arg Ala Asp Gly Gly Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Asp Asn Asp Lys Met Val Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Leu Thr Pro Asp Met Met Val Glu Ala Gly Gln Thr Leu Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Thr Pro Asp Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu His Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Leu Asn Leu Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Leu Arg Asp Gly Thr Ile Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Leu Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Trp Gln 
            340                 


<210>  254
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamE polypeptide

<400>  254

Met Ser Glu Thr Gln Ser Pro Phe Asp Gly Gly Gly Pro Pro Val Val 
1               5                   10                  15      


Leu Thr Gly Val Gly His Tyr Phe Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Val Pro Gly Ile Asp Ala Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Lys His Thr Gly Val Lys Thr Arg His Phe Ala Gly Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Lys Gln Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Leu Ser Asp Val Asp Leu Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Gln Asn Tyr Met Asp 
            100                 105                 110         


Ile Ser Leu Pro Val Gln Arg Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Ala Met Leu Ala Ser Thr Gly Gly Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Ser Pro Arg Ala Met Leu Asn Phe Gly Phe Lys Asn 
                165                 170                 175     


Ser Gly Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Lys Gly 
            180                 185                 190         


Glu Ser Val Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Leu 
        195                 200                 205             


Leu Asp Val Val Leu Arg Ala Asp Gly Gly Tyr Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Glu Asp Asn Asp Lys Met Val Ile Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Leu Val Asp Ala Gly Gln Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Thr Pro Glu Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Leu His Pro Met Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Met Leu Leu Asn Val Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Leu Arg Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Glu Leu Leu Leu Gly Val Ser Ile Gly Arg Gly Met Ser Phe 
                325                 330                 335     


Gly Ala Met Val Phe Arg Tyr Gln 
            340                 


<210>  255
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamE polypeptide

<400>  255

Met Ser Glu Thr Gln Ser Pro Phe Asp Gly Gly Gly Pro Pro Val Leu 
1               5                   10                  15      


Leu Ser Gly Ile Gly His Tyr Tyr Pro Gly Glu Pro Val Thr Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Gly Leu Asp Ala Asp Asp Ala Trp Ile Arg 
        35                  40                  45              


Lys His Thr Gly Val Arg Thr Arg His Phe Ala Ala Pro Glu Glu Arg 
    50                  55                  60                  


Phe Ala Asp Met Gly Val Lys Ala Ala Arg Gln Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Ile Asp Ile Ser Asp Val Asp Leu Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Gly Arg Pro Arg Ala Asn Pro Ser Ser Ile Gly Gln Asn Tyr Met Asp 
            100                 105                 110         


Leu Ser Val Pro Val Gln Arg Asn Leu Gly Ala Arg Glu Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Ile Leu Ala Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Thr Pro Arg Ala Ile Leu Asn Tyr Gly Phe Arg Asn 
                165                 170                 175     


Ser Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Arg Arg Gly 
            180                 185                 190         


Asp Ser Val Gly Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Leu 
        195                 200                 205             


Val Asp Val Leu Leu Arg Ala Asp Gly Gly Phe Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Ile Asp Glu Asn Asp Lys Met Val Met Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Met Met Val Glu Ala Gly Gln Thr Leu Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Ser Pro Asp Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Leu Ile His Pro Val Ala Glu Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Leu Leu Leu Asn Leu Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Asp Tyr Val Arg Asp Gly Thr Val Lys 
305                 310                 315                 320 


Pro Gly Asp Leu Leu Leu Gly Leu Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Gly Val Val Phe Arg Trp Gln 
            340                 


<210>  256
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamE polypeptide

<400>  256

Met Ser Glu Thr Gln Ser Pro Phe Asp Ala Gly Ala Pro Pro Val Val 
1               5                   10                  15      


Leu Ser Gly Val Gly His Phe Phe Pro Ala Glu Pro Val Ser Asn Asp 
            20                  25                  30          


His Phe Ala Arg Leu Pro Gly Leu Asp Ala Asp Asp Ala Trp Ile Lys 
        35                  40                  45              


Lys His Thr Gly Val Arg Thr Arg His Trp Ala Gly Pro Asp Glu Arg 
    50                  55                  60                  


Phe Ala Glu Met Gly Val Lys Ala Ala Arg Gln Ala Leu Asp Asp Ala 
65                  70                  75                  80  


Gly Leu Asp Ile Ser Asp Val Asp Leu Ile Val Gly Thr Ser Ala Thr 
                85                  90                  95      


Ala Arg Pro Arg Ala Asn Pro Ser Thr Ile Gly Asn Asn Tyr Met Asp 
            100                 105                 110         


Leu Ser Leu Pro Val Gln Lys Gln Leu Gly Ala Arg Asp Ala Phe Cys 
        115                 120                 125             


Phe Asp Val Thr Ala Val Ala Cys Ala Gly Phe Leu Tyr Ala Ser Val 
    130                 135                 140                 


Val Ala Arg Gly Leu Leu Gly Thr Thr Gly Ala Arg Thr Ala Leu Val 
145                 150                 155                 160 


Val Cys Ala Glu Thr Pro Arg Ala Leu Leu Asn Phe Gly Phe Lys Gln 
                165                 170                 175     


Thr Ala Leu Phe Gly Ala Gly Ala Ala Ala Ala Val Trp Lys Arg Gly 
            180                 185                 190         


Asp Ser Leu Ala Gly Gly Ala Asp Gly Leu Pro Thr Arg Ser Gly Leu 
        195                 200                 205             


Val Asp Ile Val Leu Arg Ala Asp Gly Gly Trp Tyr Asp Ala Phe Asp 
    210                 215                 220                 


Val Asp Glu Asn Asp Lys Met Val Val Arg Gly Gly Val Leu Ser Glu 
225                 230                 235                 240 


Val Thr Pro Asp Val Val Val Glu Ala Gly Gln Thr Val Leu Lys Arg 
                245                 250                 255     


Asn Gly Leu Thr Pro Glu Gln Ile Ser Trp Cys Val Pro His Gln Ala 
            260                 265                 270         


Asn Thr Asn Met Leu His Pro Val Ala Asp Arg Leu Gly Ile Pro Arg 
        275                 280                 285             


Glu Arg Ile Leu Val Asn Leu Pro Trp Arg Gly Asn Thr Ser Ser Val 
    290                 295                 300                 


Gly Met Pro Ser Ala Leu Ser Glu Tyr Ile Arg Asp Gly Thr Ile Lys 
305                 310                 315                 320 


Pro Gly Asp Leu Leu Leu Gly Leu Ser Ile Gly Arg Gly Leu Ser Trp 
                325                 330                 335     


Gly Ala Met Val Phe Arg Trp Gln 
            340                 


<210>  257
<211>  795
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  257
ttgtccgatt ccaggaacgc gctggtgacc gggggcaccc ggggcctggg cctggccgtc       60

ggccggatgc tggcggcgcg ggggtggcgc accacggtcc tcggcctcga ccccggccgc      120

ctcgagaagg tgcgggccat ggccgcggcc gagggcctcg acctgcgggc ggtgcgcgcc      180

gatgtcacct cggaggagtc ggttcgggag gtcttcgccg agctgacgga ggatcagccg      240

ctgcacctgt gcgtgaacaa cgcgggccgc aacctctccc ggctcctggt gcggaagccg      300

caggacgggg gaggcgccga gctgctcacg catccgctcg acgactggga gcagacgctg      360

cggctgtgcc tgacgggcgt gttcctcgtc gggcgtgagg ccgccgcgag catggtgcgg      420

cacgaggtgc cgggcgccat cgtcaatgtc tcctccggcc tcgcggcggg cgcctacggg      480

cagtccgcgt acaccgccgc gaaagcgggt gtggaggcgc tgacccgcac ctggtcctac      540

gagctcggcc cctacgggat cagggtggcg gccgtcgcgc cgggcgtcat ggacggcgag      600

gcactgcggg agaagagcac ggcctttccg cggcacgccc gctatatgga cggcctgaag      660

cgctttgttc cgctgggccg ctggcgcgcg gaggaagaga tagcggacgc cgtgtgcttc      720

gccgcggaaa acccctatgt cacgggctcg gtgattcgcg tcgacggcgg cggaccgccc      780

ggctgggtgc cgtga                                                       795


<210>  258
<211>  264
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  258

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Arg Met Leu Ala Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Ala Ala Glu Gly Leu Asp Leu Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Arg Glu Val Phe Ala Glu Leu Thr Glu Asp Gln Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Val Arg Lys Pro Gln Asp Gly Gly Gly Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Ser Met Val Arg His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Val Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  259
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamO polypeptide

<400>  259

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Arg Met Leu Ala Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Leu Glu Lys Ile Arg Ala Met Ala 
        35                  40                  45              


Ala Ala Glu Gly Leu Asp Leu Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Asp Glu Ser Val Arg Glu Val Phe Ala Glu Leu Thr Asp Asp Gln Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Val Arg Lys Pro Gln Asp Gly Gly Gly Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Ile Glu Asp Tyr Asp Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Ile Val Ala Arg Glu Ala Ala Ala Ser Met Leu Arg His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Glu Gly Glu Gly Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Val Ser Gly Thr Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  260
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamO polypeptide

<400>  260

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Lys Met Leu Ala Gly Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Gly Leu Asp Pro Gly Arg Val Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Ala Ala Glu Gly Val Asp Val Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Arg Glu Val Phe Ala Glu Leu Thr Glu Asp Gln Pro 
65                  70                  75                  80  


Leu His Ile Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Val Arg Lys Pro Gln Asp Gly Ala Gly Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Leu Asp Asp Trp Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Ser Met Val Arg His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Lys 
                165                 170                 175     


Ser Trp Ser Tyr Glu Leu Gly Pro Tyr Gly Ile Lys Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Glu Ala Met Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Asp Gly Leu Lys Lys Phe Leu Pro 
    210                 215                 220                 


Leu Gly Lys Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Val Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Trp Val Pro 
            260                 


<210>  261
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamO polypeptide

<400>  261

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Lys Met Leu Ala Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Val Gly Leu Asp Pro Gly Arg Leu Asp Lys Val Arg Ala Leu Ala 
        35                  40                  45              


Ala Ala Glu Gly Leu Asp Leu Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Arg Glu Val Phe Ala Glu Leu Thr Glu Asp Gln Pro 
65                  70                  75                  80  


Leu His Val Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Lys Leu Leu 
                85                  90                  95      


Val Arg Lys Pro Gln Asp Gly Gly Gly Ala Glu Leu Leu Thr His Pro 
            100                 105                 110         


Val Asp Asp Phe Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Trp 
        115                 120                 125             


Leu Val Gly Arg Glu Ala Ala Ala Ser Met Val Arg His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Ile Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Gly Tyr Thr Ala Ala Lys Ala Gly Val Glu Ala Leu Thr Arg 
                165                 170                 175     


Thr Trp Ser Tyr Glu Met Ala Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Tyr Met Glu Gly Ile Lys Lys Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Tyr 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Val Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Gly Tyr Leu Pro 
            260                 


<210>  262
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamO polypeptide

<400>  262

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Arg Met Leu Ala Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Leu Ala Leu Asp Pro Gly Lys Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Gly Ala Glu Gly Leu Glu Ile Arg Ala Val Arg Ala Asp Val Thr Ser 
    50                  55                  60                  


Glu Glu Ser Val Arg Glu Val Phe Ala Glu Leu Thr Glu Asp Gln Pro 
65                  70                  75                  80  


Leu His Ile Cys Val Asn Asn Ala Gly Arg Asn Val Thr Arg Leu Leu 
                85                  90                  95      


Leu Arg Lys Pro Gln Asp Gly Gly Gly Ala Glu Leu Ile Thr His Pro 
            100                 105                 110         


Val Asp Asp Trp Glu Asn Thr Leu Arg Leu Cys Leu Thr Gly Val Phe 
        115                 120                 125             


Val Val Gly Arg Glu Ala Ala Ala Ser Met Val Arg His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Phe Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Asp Gly Leu Thr Lys 
                165                 170                 175     


Ser Trp Ser Tyr Glu Val Ala Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Val Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Gly Arg Trp Met Asp Ala Leu Lys Arg Phe Val Pro 
    210                 215                 220                 


Val Gly Arg Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Met Thr Gly Ser Val Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Ala Pro Pro Gly Tyr Val Pro 
            260                 


<210>  263
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamO polypeptide

<400>  263

Met Ser Asp Ser Arg Asn Ala Leu Val Thr Gly Gly Thr Arg Gly Leu 
1               5                   10                  15      


Gly Leu Ala Val Gly Lys Ile Leu Ala Ala Arg Gly Trp Arg Thr Thr 
            20                  25                  30          


Val Val Gly Leu Asp Pro Gly Arg Leu Glu Lys Val Arg Ala Met Ala 
        35                  40                  45              


Ala Ala Glu Gly Leu Asp Val Arg Ala Ile Lys Gly Asp Val Thr Ser 
    50                  55                  60                  


Asp Asp Ser Val Lys Glu Val Phe Ala Glu Leu Thr Glu Asp Gln Pro 
65                  70                  75                  80  


Leu His Leu Cys Val Asn Asn Ala Gly Arg Asn Leu Ser Arg Leu Leu 
                85                  90                  95      


Val Arg Lys Pro Gln Asp Gly Gly Gly Ala Glu Leu Val Thr His Pro 
            100                 105                 110         


Met Asp Asp Trp Glu Gln Thr Leu Arg Leu Cys Leu Thr Gly Val Tyr 
        115                 120                 125             


Leu Val Gly Arg Asp Ala Ala Ala Ser Met Ile Lys His Glu Val Pro 
    130                 135                 140                 


Gly Ala Ile Val Asn Val Ser Ser Gly Leu Ala Ala Gly Ala Tyr Gly 
145                 150                 155                 160 


Gln Ser Ala Tyr Thr Ala Ala Lys Ala Gly Val Asp Gly Leu Thr Arg 
                165                 170                 175     


Ser Trp Ser Tyr Glu Leu Ala Pro Tyr Gly Ile Arg Val Ala Ala Val 
            180                 185                 190         


Ala Pro Gly Leu Met Asp Gly Glu Ala Leu Arg Glu Lys Ser Thr Ala 
        195                 200                 205             


Phe Pro Arg His Ala Arg Phe Met Asp Ala Val Lys Arg Phe Val Pro 
    210                 215                 220                 


Leu Gly Arg Trp Arg Ala Glu Glu Glu Ile Ala Asp Ala Val Cys Phe 
225                 230                 235                 240 


Ala Ala Glu Asn Pro Tyr Ile Thr Gly Ser Ile Ile Arg Val Asp Gly 
                245                 250                 255     


Gly Gly Pro Pro Ala Trp Val Pro 
            260                 


<210>  264
<211>  975
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  264
atgacgactg ggcgccacgg catctgggaa gacgccggaa tacgcttcac cggattcggc       60

cattatttcg gctcggagga gatacacaac cagggcgtcg acgacgcgac gacgagcgtc      120

gtggaggacc gcgtcatcgg cggagtcggc gtacgcaccc gctaccgggc gagcgaccgg      180

gaaacccccg tgttcatggc cgcggaggca tcccggcagg cgctggaacg ggccgggacc      240

gacgccgacg acattgacgt cgttgtcgtc agccactgga cggaccgcaa ctacgtgcac      300

gaagtgggcg cgctgaccgc ggcggagctc ggcatgaagg gctccatggc cttcgaagtc      360

tgcggctcct gcgccgggtt catccaggcg gtgcacacgg cggcgtcgtt cctgacctcc      420

ccgaccggct accgcaaggc gctggtggcg accaccgagc gcgtcacccg gcgggtgcgg      480

ccgggctcga agggctcgat gctcgtttcc gacggcgccg gcgcctgcgt gctcgaagcg      540

acccccggcg gctcgcccgg cctgatcgat tccgtgttcc acaccgacgg cagcctcgcc      600

aacatgtccg cggcgagcgg ggagaagggg tgggtcaaga gccaccccga cctcaacgac      660

gtggccctcg cgcacatcgc cgacaccgtg gaggagatcc tcggccgcaa caagctgacc      720

atcggggaca tcgactggct catcccacac tcgggcaccg agccgctggc caagggcatc      780

cagcacaacc tgggcgcgga cccggcgcgc gtgctgacca acctcgcctt ccgcggcaac      840

gtctccagcg cctccatccc caccaccgtg tccgagctgc gggaacgcgg cgtcgtcaaa      900

cccggcgacc tggtgctctc cccctccatc ggcggcgggg tctggtgctg gggcagcctc      960

ctgtaccgga tctga                                                       975


<210>  265
<211>  324
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  265

Met Thr Thr Gly Arg His Gly Ile Trp Glu Asp Ala Gly Ile Arg Phe 
1               5                   10                  15      


Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Val Glu Asp Arg Val Ile Gly Gly 
        35                  40                  45              


Val Gly Val Arg Thr Arg Tyr Arg Ala Ser Asp Arg Glu Thr Pro Val 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Glu Arg Ala Gly Thr 
65                  70                  75                  80  


Asp Ala Asp Asp Ile Asp Val Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Asn Tyr Val His Glu Val Gly Ala Leu Thr Ala Ala Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala Gly Phe Ile 
        115                 120                 125             


Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ser Pro Thr Gly Tyr 
    130                 135                 140                 


Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg Arg Val Arg 
145                 150                 155                 160 


Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile Asp Ser Val 
            180                 185                 190         


Phe His Thr Asp Gly Ser Leu Ala Asn Met Ser Ala Ala Ser Gly Glu 
        195                 200                 205             


Lys Gly Trp Val Lys Ser His Pro Asp Leu Asn Asp Val Ala Leu Ala 
    210                 215                 220                 


His Ile Ala Asp Thr Val Glu Glu Ile Leu Gly Arg Asn Lys Leu Thr 
225                 230                 235                 240 


Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr Glu Pro Leu 
                245                 250                 255     


Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Leu 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Ser Glu Leu Arg Glu Arg Gly Val Val Lys Pro Gly Asp Leu 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Leu 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  266
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamK polypeptide

<400>  266

Met Thr Thr Gly Arg His Gly Ile Trp Glu Asp Ala Gly Ile Arg Phe 
1               5                   10                  15      


Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Val Glu Asp Arg Val Ile Ala Gly 
        35                  40                  45              


Val Gly Val Arg Thr Arg Tyr Arg Ala Ser Glu Arg Glu Thr Pro Ile 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Glu Arg Ala Gly Thr 
65                  70                  75                  80  


Asp Ala Asp Glu Ile Asp Val Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Asn Tyr Val His Glu Val Gly Ala Leu Thr Ala Gly Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala Gly Phe Val 
        115                 120                 125             


Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ser Pro Thr Gly Tyr 
    130                 135                 140                 


Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Met Thr Arg Arg Leu Arg 
145                 150                 155                 160 


Pro Gly Ser Arg Gly Thr Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile Asp Ser Val 
            180                 185                 190         


Phe His Ser Asp Gly Ser Leu Ala Asn Val Ser Ala Ala Ser Gly Glu 
        195                 200                 205             


Arg Gly Trp Ile Arg Ser His Pro Asp Leu Asn Asp Val Ala Val Ala 
    210                 215                 220                 


His Ile Ala Asp Thr Val Glu Glu Ile Leu Gly Arg Asn Lys Leu Thr 
225                 230                 235                 240 


Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr Glu Pro Leu 
                245                 250                 255     


Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Leu 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Ser Glu Leu Arg Glu Arg Gly Val Val Lys Pro Gly Glu Leu 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Leu 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  267
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamK polypeptide

<400>  267

Met Thr Thr Gly Arg His Gly Ile Trp Glu Asp Ala Ala Ile Arg Phe 
1               5                   10                  15      


Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Val Glu Glu Arg Val Ile Gly Gly 
        35                  40                  45              


Val Gly Val Arg Thr Arg Tyr Arg Ala Thr Asp Arg Glu Thr Pro Val 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Glu Arg Ala Gly Thr 
65                  70                  75                  80  


Asp Ala Asp Asp Ile Asp Leu Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Asn Tyr Val His Glu Leu Gly Ala Leu Thr Ala Ala Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Asp Val Cys Gly Ser Cys Ala Gly Phe Ile 
        115                 120                 125             


Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Thr Pro Thr Gly Tyr 
    130                 135                 140                 


Arg Lys Ala Leu Val Ala Thr Thr Glu Lys Val Thr Arg Arg Val Arg 
145                 150                 155                 160 


Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Leu Asp Ser Val 
            180                 185                 190         


Phe His Thr Asp Gly Ser Leu Gly Asn Leu Ser Ala Ala Ser Gly Glu 
        195                 200                 205             


Lys Gly Phe Val Lys Ser His Pro Asp Leu Asn Glu Val Ala Leu Ala 
    210                 215                 220                 


His Met Ala Asp Thr Val Glu Glu Ile Leu Gly Arg Asn Lys Leu Thr 
225                 230                 235                 240 


Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr Glu Pro Met 
                245                 250                 255     


Ala Lys Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Leu 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Ser Glu Val Arg Glu Arg Gly Val Val Lys Pro Gly Asp Leu 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Met 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  268
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamK polypeptide

<400>  268

Met Thr Thr Gly Arg His Gly Ile Trp Glu Asp Ala Gly Leu Arg Phe 
1               5                   10                  15      


Thr Gly Phe Gly His Tyr Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Val Glu Asp Arg Val Ile Gly Gly 
        35                  40                  45              


Val Gly Val Arg Thr Arg Tyr Arg Ala Ser Asp Arg Glu Thr Pro Val 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Asp Arg Ala Gly Thr 
65                  70                  75                  80  


Glu Ala Asp Asp Ile Asp Ile Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Asn Tyr Val His Glu Ile Gly Ala Val Thr Ala Gly Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala Gly Phe Ile 
        115                 120                 125             


Gln Ala Val His Thr Ala Ala Ser Tyr Leu Thr Ser Pro Thr Gly Tyr 
    130                 135                 140                 


Arg Lys Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg Arg Leu Arg 
145                 150                 155                 160 


Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Leu Asp Ser Val 
            180                 185                 190         


Phe His Thr Asp Gly Ser Leu Gly Asn Met Ser Ala Ala Ser Gly Glu 
        195                 200                 205             


Lys Gly Trp Val Lys Ser His Pro Asp Leu Asn Glu Val Ala Met Ala 
    210                 215                 220                 


His Leu Ala Glu Thr Val Glu Asp Ile Leu Gly Arg Asn Lys Met Thr 
225                 230                 235                 240 


Leu Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr Glu Pro Val 
                245                 250                 255     


Ala Arg Gly Ile Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Leu 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Ser Glu Leu Arg Glu Arg Gly Leu Ile Lys Pro Gly Asp Ile 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Leu 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  269
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamK polypeptide

<400>  269

Met Thr Thr Gly Arg His Gly Leu Trp Glu Asp Ala Gly Ile Arg Phe 
1               5                   10                  15      


Thr Gly Tyr Gly His Tyr Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Val Glu Glu Lys Val Ile Gly Gly 
        35                  40                  45              


Val Gly Val Lys Thr Arg Tyr Arg Ala Thr Glu Arg Glu Thr Pro Met 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Asp Lys Ala Gly Thr 
65                  70                  75                  80  


Glu Ala Asp Asp Ile Asp Val Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Gln Tyr Val His Glu Met Gly Gly Met Thr Ala Gly Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Asp Val Cys Gly Ser Cys Ala Gly Phe Leu 
        115                 120                 125             


Gln Ala Val His Thr Ala Ala Ser Phe Leu Thr Ser Pro Thr Gly Tyr 
    130                 135                 140                 


Arg Lys Ala Leu Val Ala Thr Thr Glu Lys Val Thr Arg Arg Val Arg 
145                 150                 155                 160 


Pro Gly Ser Lys Gly Thr Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Ile Asp Ser Val 
            180                 185                 190         


Phe His Thr Asp Gly Ser Leu Ala Asn Val Ser Ala Ala Ser Gly Glu 
        195                 200                 205             


Lys Gly Tyr Met Lys Ser His Pro Asp Leu Asn Asp Val Ala Met Ala 
    210                 215                 220                 


His Ile Ala Glu Thr Leu Glu Glu Leu Leu Gly Arg Asn Lys Leu Thr 
225                 230                 235                 240 


Ile Gly Asp Ile Asp Phe Leu Ile Pro His Ser Gly Thr Glu Pro Ile 
                245                 250                 255     


Ala Lys Ala Ile Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Ile 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Thr Glu Leu Arg Glu Arg Gly Val Leu Lys Pro Gly Asp Leu 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Leu 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  270
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamK polypeptide

<400>  270

Met Thr Thr Gly Arg His Gly Ile Trp Glu Asp Ala Gly Leu Arg Phe 
1               5                   10                  15      


Thr Gly Phe Gly His Phe Phe Gly Ser Glu Glu Ile His Asn Gln Gly 
            20                  25                  30          


Val Asp Asp Ala Thr Thr Ser Val Leu Glu Glu Arg Val Val Gly Gly 
        35                  40                  45              


Val Gly Val Arg Thr Arg Tyr Arg Ala Ser Asp Lys Glu Thr Pro Val 
    50                  55                  60                  


Phe Met Ala Ala Glu Ala Ser Arg Gln Ala Leu Glu Lys Ala Gly Thr 
65                  70                  75                  80  


Asp Ala Glu Asp Ile Asp Leu Val Val Val Ser His Trp Thr Asp Arg 
                85                  90                  95      


Asn Phe Met His Glu Val Gly Gly Ile Thr Ala Ala Glu Leu Gly Met 
            100                 105                 110         


Lys Gly Ser Met Ala Phe Glu Val Cys Gly Ser Cys Ala Gly Phe Ile 
        115                 120                 125             


Asn Ala Val His Thr Ala Ala Ser Phe Leu Thr Ser Pro Thr Ala Tyr 
    130                 135                 140                 


Lys Arg Ala Leu Val Ala Thr Thr Glu Arg Val Thr Arg Arg Val Arg 
145                 150                 155                 160 


Pro Gly Ser Lys Gly Ser Met Leu Val Ser Asp Gly Ala Gly Ala Cys 
                165                 170                 175     


Val Leu Glu Ala Thr Pro Gly Gly Ser Pro Gly Leu Leu Asp Thr Val 
            180                 185                 190         


Phe His Thr Asp Gly Ser Leu Ala Asn Leu Ser Gly Ala Ser Gly Glu 
        195                 200                 205             


Lys Ala Tyr Leu Arg Ser His Pro Asp Leu Asn Asp Val Ala Val Ala 
    210                 215                 220                 


His Val Ala Asp Thr Val Asp Glu Leu Leu Ala Arg Asn Lys Leu Thr 
225                 230                 235                 240 


Ile Gly Asp Ile Asp Trp Leu Ile Pro His Ser Gly Thr Glu Pro Leu 
                245                 250                 255     


Ala Lys Gly Val Gln His Asn Leu Gly Ala Asp Pro Ala Arg Val Leu 
            260                 265                 270         


Thr Asn Leu Ala Phe Arg Gly Asn Val Ser Ser Ala Ser Ile Pro Thr 
        275                 280                 285             


Thr Val Ser Glu Val Arg Glu Arg Gly Val Val Lys Pro Gly Asp Leu 
    290                 295                 300                 


Val Leu Ser Pro Ser Ile Gly Gly Gly Val Trp Cys Trp Gly Ser Met 
305                 310                 315                 320 


Leu Tyr Arg Ile 
                


<210>  271
<211>  1296
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  271
gtgaccacga ccaagagccc ccgggacgca ctcgtcaccg gcatgggctt ctgtctgccg       60

gggcgcgtgg cgccgacggc gacacccgac cagttctgga cggccgtcgc gcacggcggc      120

tcgttcctcg cgcaggacga cggcacctac ttcggcagtg tgcccctcga cccgcagtcc      180

gtcgtcgacc ggctgccgga gatcccgccg cgcttcgtcg cgaagtactc cgacatccat      240

ctgtacgggc tgctcgccct gctcgaagcc tgcgaggacg ccgctctcga ctggcgtacg      300

ggcgcgctgc gcgaggccgc ggtgctcgcg ggcaggaacg ccacggccga cgccatcgtc      360

gacacctacc tgccggtgct gctcgccgac acccggcaca tcagcccgcg cgaggcccgc      420

tccgtgctgt tccgcaacgt cctcaacgcg gtgatgtcgg acgtcgagac cacccaggcg      480

ggcctcgtgg gcgccaccgg ccccagctac acgctgtcct gcggatgcgc ctcgtccgcc      540

gtactgatcg gcaacgcggc ccgcatgatc gcggcgggcg agacggacat cgcggtcgtc      600

accggcgccg actactggcg cgagagccgc ctgcgccagt acgccgaact cgaggcacgc      660

tcggtgaccg gaaccgaacc gcagaccgcc accctcatcg acgaacccat gcgcccctac      720

gacgagcggg cggccggcct caactacggc aacggcgccg ccacgctgat cctggagagc      780

cgcgagcacg cccggcgcag gggagcgcgg acctacggcc aaatcctcgg ccagaccacc      840

acgcgcaacg cccagccgaa cctggccctc gacaccgggg gcgccggggc ggtgcgcgcc      900

gcgcgctcct gcatggcggg cctcgcctcg cccgacgaga tcgactacgt caacggcgcc      960

gcgaccggcg accgggcgtt caacctcatg gagggcaaca tcatgcccgc gatcttcgga     1020

gagcggacgg cccagctgcc cgtcaccgtt caagaggccg tgttcgggca cagcggggca     1080

ccgctcggcg tgatcggcgt ggccgccacg ctccagatga tgcgccacgg ccgcatcgcc     1140

ccgaccgcca actgcgagaa gcccgccgac gtgtgcacct tcgacccggt gcccggcacg     1200

gagggccgac ccgcgcgcct cgacctggcc ctcagcctca actacacgat cggctccgtg     1260

gccagtgcca ttctcgtggg aggctccgat gactga                               1296


<210>  272
<211>  431
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  272

Met Thr Thr Thr Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Val Ala Pro Thr Ala Thr Pro Asp Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Leu Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Val Pro Leu Asp Pro Gln Ser Val Val Asp Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Ala Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Thr Gly Ala Leu Arg Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Ala Ile Val Asp Thr Tyr Leu Pro Val Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg His Ile Ser Pro Arg Glu Ala Arg Ser Val Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ala Val Leu Ile Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Glu Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Thr Glu Pro Gln Thr Ala Thr Leu Ile Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Glu Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Glu Arg Thr Ala Gln Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Arg His Gly Arg Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Gly Arg Pro Ala Arg Leu Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Val Gly Gly Ser Asp Asp 
            420                 425                 430     


<210>  273
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamJ polypeptide

<400>  273

Met Thr Thr Thr Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Ile Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Val Ala Pro Thr Ala Thr Pro Asp Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Ile Ala Gln Asp Glu Ala 
        35                  40                  45              


Thr Tyr Phe Gly Ser Val Pro Leu Asp Pro Gln Ser Val Val Asp Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Ala Lys Tyr Ser Asp Met His 
65                  70                  75                  80  


Leu Tyr Gly Met Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Lys Thr Gly Ala Leu Arg Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Gly Thr Ala Asp Ala Ile Val Asp Thr Tyr Leu Pro Leu Leu Leu 
        115                 120                 125             


Gly Asp Thr Arg His Ile Ser Pro Arg Glu Ala Arg Ser Val Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Gln Ala Ile Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ala Val Leu Ile Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Ser Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Phe Arg Glu 
        195                 200                 205             


Thr Arg Leu Arg Gln Tyr Ala Glu Val Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Thr Glu Pro Gln Ser Ala Thr Leu Ile Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Glu Arg Ala Gly Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Gln Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Glu Arg Thr Ala Gln Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Arg His Gly Arg Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Asp Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Ala Arg Pro Ala Arg Leu Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Ile Ala Ser Ala Ile Leu Val Gly Gly Ser Asp Asp 
            420                 425                 430     


<210>  274
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamJ polypeptide

<400>  274

Met Thr Thr Thr Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Val Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Leu Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Ile Pro Leu Asp Pro Gln Ser Val Val Asp Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Ala Arg Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Thr Gly Ala Leu Arg Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Ala Ile Val Asp Thr Tyr Leu Pro Leu Ile Leu 
        115                 120                 125             


Gly Asp Thr Arg His Val Ser Pro Arg Glu Ala Arg Ser Leu Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Val Met Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Gly Val Leu Ile Gly Asn Ala Ala Lys Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Glu Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Thr Asp Pro Gln Thr Gly Thr Leu Leu Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Glu Arg Ala Ala Gly Leu Asn Trp Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Met Leu Glu Ala Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Glu Arg Thr Ala Gln Ile Pro Val Thr Val Gln Glu 
            340                 345                 350         


Gly Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Leu Gly Val Ala 
        355                 360                 365             


Ala Thr Val Gln Met Met Arg His Gly Arg Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Gly Arg Pro Ala Arg Leu Asp Ile Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Val Gly Gly Ser Asp Asp 
            420                 425                 430     


<210>  275
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamJ polypeptide

<400>  275

Met Thr Thr Thr Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Val Ala Pro Thr Ala Thr Pro Asp Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Ile Ala Gln Asp Asp Gly 
        35                  40                  45              


Ser Tyr Trp Gly Ser Ile Pro Leu Asp Pro Gln Ser Leu Val Asp Arg 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Leu Ala Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Leu Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Arg Thr Gly Gly Leu Lys Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Ser Ala Asp Ala Met Leu Glu Thr Tyr Leu Pro Leu Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg His Leu Ser Pro Arg Glu Ala Arg Ser Val Ile Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Gly Val Ile Ser Asp Val Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ala Val Leu Ile Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Glu Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Thr Asp Pro Gln Thr Ala Thr Leu Ile Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Glu Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Arg Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Val Gly Gln Thr Ser Thr Arg Asn Ala Gln Pro Asn Val 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Leu Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Thr Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Ile Glu Ala Asn Ile Met Pro 
                325                 330                 335     


Ala Ile Phe Gly Asp Lys Thr Ala Gln Ile Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Arg His Gly Arg Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Leu Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Ala Arg Pro Ala Lys Leu Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Val Gly Gly Ser Asp Asp 
            420                 425                 430     


<210>  276
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamJ polypeptide

<400>  276

Met Thr Thr Thr Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Ala Arg Val Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Ile Ala Gln Asp Asp Gly 
        35                  40                  45              


Thr Tyr Phe Gly Ser Leu Pro Leu Asp Pro Gln Ser Val Leu Asp Lys 
    50                  55                  60                  


Leu Pro Glu Ile Pro Pro Arg Phe Val Ala Lys Tyr Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Met Val Ala Leu Val Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Glu Trp Arg Thr Ala Gly Leu Arg Glu Ala Gly Val Val Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Glu Ala Leu Leu Glu Thr Tyr Leu Pro Leu Val Leu 
        115                 120                 125             


Ala Asp Thr Arg His Ile Ser Pro Arg Glu Ala Arg Ser Val Leu Phe 
    130                 135                 140                 


Arg Asn Val Leu Asn Ala Met Leu Ser Asp Ile Glu Thr Thr Gln Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Thr Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ala Ile Leu Ile Gly Asn Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Asp Thr Asp Leu Ala Val Val Thr Gly Ala Asp Tyr Trp Arg Glu 
        195                 200                 205             


Ser Arg Leu Arg Gln Tyr Ala Glu Leu Glu Ala Arg Ser Val Thr Gly 
    210                 215                 220                 


Ser Asp Pro Gln Thr Ala Ser Met Ile Asp Glu Pro Leu Arg Pro Tyr 
225                 230                 235                 240 


Asp Glu Arg Ala Ala Gly Leu Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Thr Arg Asp His Ala Arg Lys Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Leu Gly Gln Thr Thr Ser Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Leu Arg Ala Ala Lys Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Lys Ala Phe Asn Leu Val Glu Gly Asn Ile Met Pro 
                325                 330                 335     


Ala Val Phe Gly Glu Arg Thr Ala Gln Val Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Leu Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Arg His Gly Lys Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Gly Arg Pro Ala Arg Val Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Val Gly Gly Ser Asp Asp 
            420                 425                 430     


<210>  277
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamJ polypeptide

<400>  277

Met Thr Thr Ser Lys Ser Pro Arg Asp Ala Leu Val Thr Gly Met Gly 
1               5                   10                  15      


Phe Cys Leu Pro Gly Arg Val Ala Pro Thr Ala Thr Pro Glu Gln Phe 
            20                  25                  30          


Trp Thr Ala Val Ala His Gly Gly Ser Phe Leu Ala Gln Asp Asp Gly 
        35                  40                  45              


Ser Tyr Phe Gly Ser Val Pro Leu Asp Pro Asn Ser Ile Val Asp Lys 
    50                  55                  60                  


Val Pro Glu Ile Pro Pro Lys Phe Val Ala Arg Phe Ser Asp Ile His 
65                  70                  75                  80  


Leu Tyr Gly Leu Val Ala Leu Leu Glu Ala Cys Glu Asp Ala Ala Leu 
                85                  90                  95      


Asp Trp Lys Thr Gly Ala Leu Arg Glu Ala Ala Val Leu Ala Gly Arg 
            100                 105                 110         


Asn Ala Thr Ala Asp Gly Ile Val Asp Thr Trp Ile Pro Val Leu Leu 
        115                 120                 125             


Ala Asp Thr Arg His Ile Ser Pro Arg Glu Gly Arg Ser Ile Leu Phe 
    130                 135                 140                 


Arg Asn Ile Leu Asn Ala Ile Leu Thr Asp Val Glu Thr Thr Asn Ala 
145                 150                 155                 160 


Gly Leu Val Gly Ala Thr Gly Pro Ser Tyr Ser Leu Ser Cys Gly Cys 
                165                 170                 175     


Ala Ser Ser Ala Val Leu Ile Ala Gln Ala Ala Arg Met Ile Ala Ala 
            180                 185                 190         


Gly Glu Thr Asp Ile Ala Val Val Thr Gly Ala Asp Tyr Trp Lys Glu 
        195                 200                 205             


Thr Arg Leu Arg Gln Phe Ala Asp Met Glu Ala Arg Ser Val Thr Ala 
    210                 215                 220                 


Thr Asp Pro Gln Ser Ala Thr Met Ile Asp Glu Pro Met Arg Pro Tyr 
225                 230                 235                 240 


Asp Asp Arg Ala Ala Gly Ile Asn Tyr Gly Asn Gly Ala Ala Thr Leu 
                245                 250                 255     


Ile Leu Glu Ser Arg Glu His Ala Arg Lys Arg Gly Ala Arg Thr Tyr 
            260                 265                 270         


Gly Gln Ile Leu Gly Gln Thr Thr Thr Arg Asn Ala Gln Pro Asn Leu 
        275                 280                 285             


Ala Leu Asp Thr Gly Gly Ala Gly Ala Val Arg Ala Ala Arg Ser Cys 
    290                 295                 300                 


Met Ala Gly Leu Ala Ser Pro Asp Glu Ile Asp Tyr Val Asn Gly Ala 
305                 310                 315                 320 


Ala Thr Gly Asp Arg Ala Phe Asn Leu Met Glu Gly Gln Ile Met Pro 
                325                 330                 335     


Gly Leu Phe Gly Asp Arg Thr Gly Gln Leu Pro Val Thr Val Gln Glu 
            340                 345                 350         


Ala Val Phe Gly His Ser Gly Ala Pro Leu Gly Val Ile Gly Val Ala 
        355                 360                 365             


Ala Thr Leu Gln Met Met Arg His Gly Arg Ile Ala Pro Thr Ala Asn 
    370                 375                 380                 


Cys Glu Lys Pro Ala Asp Val Cys Thr Phe Asp Pro Val Pro Gly Thr 
385                 390                 395                 400 


Glu Gly Arg Pro Ala Arg Ile Asp Leu Ala Leu Ser Leu Asn Tyr Thr 
                405                 410                 415     


Ile Gly Ser Val Ala Ser Ala Ile Leu Val Gly Ala Ser Asp Asp 
            420                 425                 430     


<210>  278
<211>  1539
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  278
atgactgagc acacccgggc cccgcagcac acggaggccg ccgggccgct cctggagacg       60

gagtccctcg cccccgtcgg ccgccgcgtc ctgctggaat ccacgcccgg cgccgcccac      120

acccgcgcgg tcgaggacgc ctgggagcgc cacggcttcc acgtcaccgc cgtcaacggc      180

gcggacacgc ccgaaccccc ggacgtgtac tgcgtcgtgg ccctcggcaa cgaggcgctc      240

ggcggccgca cctggacacc gctgcgccgc gcccatgtgg cccgcgtcct ggaggccatg      300

gtccgccgcg gcgacggccg tgccgtcctg gtcaccgacg ccggaccgca cgtccacgac      360

gacgcggagc cggagtgcgc ggcggagcgg gcggccgacc acgcctggtg gcagcacctg      420

gccaagtggt gcgccgtccg gggggtgctc gccaacaccg tacgcgtcgg atacgcgccg      480

ttcctcgggc acgagctcac cgacgaggcc gcgggcgaac tgctccgcca cctcgtcacc      540

cgccgccccg tcgcaccgcg ggaactggcg gcggcgctgc gcctgctggc ctcacgcggc      600

ttcggcaaca tcgcgggcga gacgctgccc ctggacggcg ggctcgacgc gggcatcgtg      660

cccatgccgt cggcccgccc gccgcggccc ggagcgaccg ccgacgcggc ggacgacccg      720

caggcgcccg acccgttccg gctgaccggg cgcgtcgccc tcatcaccgg cgcgagcagc      780

ggcatcggcg cgagcatcgc gcgggagtgc gcggcccgcg gcgccgacgt cgtcctcgtc      840

gcacgtcgcc gccccgagct ggagaagctc gccgccgagg tccgtgaact gggccgcagg      900

gcctgggtgg tgaccgccga cctgtccgac cccgcgcggg cggccggcct ggtgcacgag      960

gcgtgggagc gcaccggagg cgtcgacgcc ctcgtctacg ccgcgggcgc cgtctccttc     1020

gacggcgccg gtgacaactc cgccaaccgg cagcggctcc tcgccctcaa ctcgctgtcg     1080

tacgccggta cgtgcgacgc gctgctcaag cactgggcgg cgtccggccg gggcggcgcc     1140

gtggccgccg tctcctcgct ggccgcggtg agcgcgccgg tggcgaacct ggcgagctac     1200

ggcctcagca aggcggcgac cgcccagttc accagccact tcgccacctc ggcggcccgg     1260

ttcaaggtgc gggccaacag cgtgctcccg ggcttcgtcc gcaccccgat gacggacgtc     1320

accaaccccg ccttcctgga cgcgaccaac cggctcgtgc ccaccggccg gatgagcgag     1380

cccaccgagg tcgcggcgct cgtctgctac ctcatcagcc ccgcggcggc cgggctgacc     1440

ggcgcccagc tgcgcgtgga cggcggcggc cactgcctgg ccgggctgcc gaacctggac     1500

ccaacccagc accccctcga ggaaggaacc cggctgtga                            1539


<210>  279
<211>  512
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  279

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Thr Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Glu Arg His Gly Phe His Val Thr Ala Val Asn Gly Ala Asp Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Arg Thr Trp Thr Pro Leu Arg Arg Ala His Val Ala Arg Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Arg Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Gly Pro His Val His Asp Asp Ala Glu Pro Glu Cys Ala Ala 
        115                 120                 125             


Glu Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Ala Pro 
145                 150                 155                 160 


Phe Leu Gly His Glu Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
                165                 170                 175     


His Leu Val Thr Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Ala Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Ile Ala Gly Glu Thr 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Leu Asp Ala Gly Ile Val Pro Met Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Gly Ala Thr Ala Asp Ala Ala Asp Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
            260                 265                 270         


Arg Gly Ala Asp Val Val Leu Val Ala Arg Arg Arg Pro Glu Leu Glu 
        275                 280                 285             


Lys Leu Ala Ala Glu Val Arg Glu Leu Gly Arg Arg Ala Trp Val Val 
    290                 295                 300                 


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Gly Leu Val His Glu 
305                 310                 315                 320 


Ala Trp Glu Arg Thr Gly Gly Val Asp Ala Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Ala Val Ser Phe Asp Gly Ala Gly Asp Asn Ser Ala Asn Arg Gln Arg 
            340                 345                 350         


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Thr Cys Asp Ala Leu 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Gly Arg Gly Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Leu Ala Ala Val Ser Ala Pro Val Ala Asn Leu Ala Ser Tyr 
385                 390                 395                 400 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Ala Ala Arg Phe Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
            420                 425                 430         


Val Arg Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Leu Asp Ala 
        435                 440                 445             


Thr Asn Arg Leu Val Pro Thr Gly Arg Met Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Ala Leu Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
465                 470                 475                 480 


Gly Ala Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
                485                 490                 495     


Pro Asn Leu Asp Pro Thr Gln His Pro Leu Glu Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  280
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamM polypeptide

<400>  280

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Thr Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Asp Arg His Gly Phe His Val Thr Ala Val Asn Gly Ala Glu Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Arg Thr Trp Thr Pro Leu Arg Arg Ala His Val Ala Arg Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Arg Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Gly Pro His Val His Asp Asp Ala Glu Pro Glu Cys Gly Ala 
        115                 120                 125             


Glu Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Ala Pro 
145                 150                 155                 160 


Phe Leu Gly His Asp Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
                165                 170                 175     


His Leu Val Thr Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Gly Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Gly Phe Ala Asn Val Ala Gly Glu Ser 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Leu Asp Ala Gly Ile Val Pro Met Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Ala Ala Thr Ala Asp Ala Ala Asp Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
            260                 265                 270         


Arg Gly Ala Asp Val Val Leu Val Gly Arg Arg Arg Pro Glu Leu Glu 
        275                 280                 285             


Lys Ile Ala Ala Glu Val Arg Glu Ile Gly Arg Arg Ala Trp Ile Ile 
    290                 295                 300                 


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Gly Leu Val His Glu 
305                 310                 315                 320 


Ala Phe Glu Arg Thr Gly Gly Val Asp Ala Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Ala Val Ser Phe Asp Ala Ala Gly Asp Asn Ser Ala Gln Arg Gln Arg 
            340                 345                 350         


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Thr Cys Asp Ala Ile 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Gly Arg Gly Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Val Ala Ala Val Ser Ala Pro Val Ala Asn Leu Ala Thr Tyr 
385                 390                 395                 400 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Ala Gly Arg Phe Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
            420                 425                 430         


Val Arg Thr Pro Leu Thr Asp Val Thr Asn Pro Ala Phe Leu Asp Ala 
        435                 440                 445             


Thr Asn Arg Leu Val Pro Thr Gly Lys Met Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Ala Leu Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
465                 470                 475                 480 


Gly Ala Gln Leu Arg Val Asp Gly Gly Ala His Cys Leu Gly Gly Leu 
                485                 490                 495     


Pro Asn Leu Asp Pro Ser Gln His Pro Leu Glu Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  281
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamM polypeptide

<400>  281

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Thr Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Glu Arg His Gly Phe His Val Thr Ala Val Asn Gly Ala Asp Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Arg Thr Trp Thr Pro Leu Lys Arg Ala His Val Ala Lys Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Arg Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Ala Pro His Val His Glu Asp Ala Glu Pro Glu Cys Ala Ala 
        115                 120                 125             


Glu Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Ala Pro 
145                 150                 155                 160 


Phe Leu Ala His Asp Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
                165                 170                 175     


His Leu Val Thr Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Ala Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Val Ala Gly Glu Thr 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Leu Asp Ala Gly Ile Val Pro Met Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Ala Ala Thr Ala Asp Ala Ala Asp Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Asp Pro Phe Arg Leu Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
            260                 265                 270         


Arg Gly Ala Asp Val Val Leu Val Gly Arg Arg Arg Pro Glu Leu Glu 
        275                 280                 285             


Lys Leu Ala Ala Glu Val Lys Glu Leu Gly Arg Arg Ala Trp Ile Val 
    290                 295                 300                 


Thr Ala Asp Leu Ser Asp Pro Ala Arg Ala Ala Gly Leu Ile His Glu 
305                 310                 315                 320 


Ala Trp Asp Arg Thr Gly Gly Val Asp Ala Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Ala Leu Ser Trp Asp Gly Ala Gly Asp Asn Ser Ala Asn Arg Gln Arg 
            340                 345                 350         


Leu Leu Ala Leu Asn Ser Leu Ser Tyr Ala Gly Thr Cys Asp Ala Leu 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Gly Arg Gly Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Val Ala Ala Leu Ser Ala Pro Leu Ala Asn Val Ala Ser Tyr 
385                 390                 395                 400 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Ala Gly Arg Phe Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
            420                 425                 430         


Val Arg Thr Pro Val Thr Asp Val Ser Asn Pro Ala Phe Leu Asp Ala 
        435                 440                 445             


Thr Asn Arg Leu Val Pro Thr Gly Arg Met Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Ala Met Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Ile Thr 
465                 470                 475                 480 


Gly Ala Asn Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Leu 
                485                 490                 495     


Pro Asn Leu Asp Pro Ser Gln His Pro Leu Glu Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  282
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamM polypeptide

<400>  282

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Ser Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Glu Arg His Gly Phe His Val Thr Ala Val Asn Gly Ala Asp Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Arg Thr Trp Thr Pro Leu Arg Arg Ala His Val Ala Arg Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Lys Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Gly Pro His Val His Asp Asp Ala Glu Pro Glu Cys Ala Ala 
        115                 120                 125             


Glu Arg Ala Ala Glu His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Arg Gly Val Leu Ala Asn Thr Val Arg Val Gly Trp Ala Pro 
145                 150                 155                 160 


Phe Leu Gly His Asp Val Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
                165                 170                 175     


His Leu Val Thr Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Ala Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Ala Phe Gly Asn Val Ala Gly Glu Thr 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Leu Asp Ala Ala Ile Val Pro Leu Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Gly Ala Thr Ala Asp Ala Ala Asp Glu Pro 
225                 230                 235                 240 


Gln Ala Pro Asp Pro Trp Arg Leu Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
            260                 265                 270         


Arg Gly Ala Asp Val Ile Leu Val Ala Arg Arg Arg Pro Glu Leu Asp 
        275                 280                 285             


Lys Met Ala Ala Glu Ile Arg Glu Leu Gly Arg Arg Ala Trp Val Leu 
    290                 295                 300                 


Thr Gly Asp Leu Ser Asp Pro Ala Arg Ala Ala Gly Leu Val His Asp 
305                 310                 315                 320 


Ala Trp Glu Lys Thr Gly Gly Val Asp Gly Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Ala Val Ser Phe Asp Gly Ala Gly Asp Asn Ser Ala Asn Arg Gln Arg 
            340                 345                 350         


Leu Met Ala Leu Asn Ser Leu Ser Phe Ala Ala Thr Cys Asp Gly Leu 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Gly Lys Gly Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Leu Ala Ala Leu Thr Ala Pro Val Ala Asn Leu Ala Ser Tyr 
385                 390                 395                 400 


Ala Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Ala Ala Arg Tyr Lys Val Arg Ala Asn Ser Val Leu Pro Gly Phe 
            420                 425                 430         


Val Arg Thr Pro Met Thr Asp Val Thr Asn Pro Ala Phe Leu Glu Ala 
        435                 440                 445             


Thr Asn Arg Leu Ile Pro Thr Gly Arg Leu Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Ala Ile Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
465                 470                 475                 480 


Gly Ala Gln Leu Arg Val Asp Gly Gly Gly His Cys Leu Ala Gly Met 
                485                 490                 495     


Pro Gln Leu Asp Pro Thr Gln His Pro Leu Glu Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  283
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamM polypeptide

<400>  283

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Thr Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Glu Arg His Gly Phe His Val Ser Ala Val Asn Gly Ala Asp Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Lys Thr Trp Thr Pro Leu Arg Arg Ala His Val Ala Arg Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Arg Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Gly Pro His Val His Glu Asp Ala Glu Pro Glu Cys Ala Ala 
        115                 120                 125             


Glu Arg Ala Ala Glu His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Lys Gly Val Leu Ala Asn Thr Val Arg Val Gly Phe Ala Pro 
145                 150                 155                 160 


Phe Val Ala His Glu Leu Thr Asp Glu Ala Ala Gly Glu Leu Leu Arg 
                165                 170                 175     


His Leu Met Ser Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Ala Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Gly Phe Gly Asn Ile Ala Gly Glu Thr 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Leu Asp Ala Gly Val Leu Pro Val Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Gly Ala Thr Ala Asp Gly Ala Glu Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Glu Pro Phe Lys Leu Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Ala 
            260                 265                 270         


Arg Gly Ala Glu Val Leu Leu Leu Ala Arg Arg Arg Pro Glu Leu Glu 
        275                 280                 285             


Lys Ile Ala Ala Glu Val Arg Glu Leu Gly Lys Arg Ala Phe Val Val 
    290                 295                 300                 


Thr Gly Asp Leu Ser Asp Pro Ala Arg Ala Ala Ala Leu Leu His Glu 
305                 310                 315                 320 


Ala Trp Glu Arg Thr Gly Gly Val Asp Ala Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Ala Leu Ser Phe Asp Gly Ala Gly Asp Asn Ser Ala Asn Arg Gln Lys 
            340                 345                 350         


Leu Ile Ala Leu Asn Ser Leu Ser Phe Ala Gly Thr Cys Asp Ala Ile 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Ala Arg Gly Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Val Ala Ala Val Ser Gly Pro Val Gly Asn Met Ala Ser Tyr 
385                 390                 395                 400 


Ala Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Gly Gly Lys Phe Lys Val Arg Ala Asn Thr Val Val Pro Gly Phe 
            420                 425                 430         


Val Arg Thr Pro Met Ser Asp Val Thr Gln Pro Ala Trp Val Glu Ala 
        435                 440                 445             


Thr Asn Arg Leu Val Pro Thr Gly Arg Met Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Ala Leu Val Cys Tyr Leu Ile Thr Pro Ala Ala Ala Gly Val Thr 
465                 470                 475                 480 


Gly Ala Gln Leu Lys Val Asp Gly Gly Ala His Cys Val Ala Gly Leu 
                485                 490                 495     


Pro Asn Leu Asp Pro Thr Gln His Pro Leu Glu Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  284
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamM polypeptide

<400>  284

Met Thr Glu His Thr Arg Ala Pro Gln His Thr Glu Ala Ala Gly Pro 
1               5                   10                  15      


Leu Leu Glu Thr Glu Ser Leu Ala Pro Val Gly Arg Arg Val Leu Leu 
            20                  25                  30          


Glu Ser Thr Pro Gly Ala Ala His Thr Arg Ala Val Glu Asp Ala Trp 
        35                  40                  45              


Glu Arg His Gly Phe His Val Thr Ala Val Asn Gly Ala Asp Thr Pro 
    50                  55                  60                  


Glu Pro Pro Asp Val Tyr Cys Val Val Ala Leu Gly Asn Glu Ala Leu 
65                  70                  75                  80  


Gly Gly Arg Ser Trp Thr Pro Leu Arg Arg Ala His Val Ala Arg Val 
                85                  90                  95      


Leu Glu Ala Met Val Arg Arg Gly Asp Gly Arg Ala Val Leu Val Thr 
            100                 105                 110         


Asp Ala Gly Pro His Val His Asp Asp Ala Asp Pro Glu Cys Gly Ala 
        115                 120                 125             


Glu Arg Ala Ala Asp His Ala Trp Trp Gln His Leu Ala Lys Trp Cys 
    130                 135                 140                 


Ala Val Lys Gly Val Leu Ala Asn Thr Val Arg Val Gly Tyr Ala Pro 
145                 150                 155                 160 


Phe Leu Gly His Asp Met Ser Glu Glu Ala Ala Gly Glu Leu Val Arg 
                165                 170                 175     


His Leu Leu Thr Arg Arg Pro Val Ala Pro Arg Glu Leu Ala Gly Ala 
            180                 185                 190         


Leu Arg Leu Leu Ala Ser Arg Ala Phe Ala Asn Val Ala Gly Glu Thr 
        195                 200                 205             


Leu Pro Leu Asp Gly Gly Met Asp Ala Gly Ile Val Pro Met Pro Ser 
    210                 215                 220                 


Ala Arg Pro Pro Arg Pro Gly Ala Thr Ala Glu Ala Ala Asp Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Asp Pro Phe Arg Met Thr Gly Arg Val Ala Leu Ile Thr 
                245                 250                 255     


Gly Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Glu Cys Ala Gly 
            260                 265                 270         


Arg Gly Ala Asp Val Val Leu Val Ala Arg Arg Arg Pro Glu Val Asp 
        275                 280                 285             


Lys Val Ala Ala Glu Ile Arg Asp Leu Gly Lys Arg Ala Trp Val Val 
    290                 295                 300                 


Thr Gly Asp Leu Ser Asp Pro Ala Arg Ala Ala Gly Leu Val His Glu 
305                 310                 315                 320 


Ala Trp Glu Arg Thr Gly Gly Val Asp Ala Leu Val Tyr Ala Ala Gly 
                325                 330                 335     


Gly Met Ser Phe Asp Gly Ala Ala Asp Asn Ser Ala Asn Arg Gln Arg 
            340                 345                 350         


Leu Leu Ala Leu Asn Ser Ile Ser Tyr Ala Gly Thr Cys Glu Ala Val 
        355                 360                 365             


Leu Lys His Trp Ala Ala Ser Ala Arg Ala Gly Ala Val Ala Ala Val 
    370                 375                 380                 


Ser Ser Val Gly Ala Val Ser Ala Pro Val Ala Asn Leu Ala Ser Tyr 
385                 390                 395                 400 


Gly Leu Ser Lys Ala Ala Thr Ala Gln Phe Thr Ser His Phe Ala Thr 
                405                 410                 415     


Ser Ala Ala Lys Trp Lys Val Arg Ala Asn Ser Val Leu Pro Gly Tyr 
            420                 425                 430         


Val Arg Thr Pro Met Thr Glu Val Thr Asn Pro Ala Tyr Ile Asp Ala 
        435                 440                 445             


Thr Asn Arg Val Leu Pro Thr Gly Arg Leu Ser Glu Pro Thr Glu Val 
    450                 455                 460                 


Ala Gly Leu Val Cys Tyr Leu Ile Ser Pro Ala Ala Ala Gly Leu Thr 
465                 470                 475                 480 


Gly Ala Gln Leu Lys Val Asp Gly Gly Gly His Cys Val Gly Gly Val 
                485                 490                 495     


Pro Asn Ile Asp Pro Ser Gln His Pro Leu Asp Glu Gly Thr Arg Leu 
            500                 505                 510         


<210>  285
<211>  828
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  285
gtgaccgagg acaggcccct caagggcaag gtggcgctgg tcgccggcgc ctcgtccggc       60

atcggggcga gcatcgcccg caccctggcc caggcgggcg catcggtcgc gctcgtcgcc      120

cgccgcaagg aacaactggc ctcggtggag caggacgtgg ccggtcatga ggtgcccacc      180

gtcacgctcg tcgccgacct ggcggccgac ggcgccccca aggacatggt ggccgccgcc      240

gagcgggccc tcgggcccgt cgacatcctg gtgaacaacg ccgctctggc gcgcaccggg      300

cccatccacg acacccaccc ccgccactgg cggcacgcct tccacctcaa cctggacgtg      360

ccgttcctgc tcgcccggtc cgtgctgccg gggatgcgcg aacgcggcca cggctggatc      420

gtcaacatca gctccgaggg cagcctgctg caggccgact ggtcggcccc gtactccatc      480

accaagcgcg ccctgaacgc gctgaccgcg caagtggacc tggagaaccg gcacttgggg      540

gtgcgcgcca tcgccgtgct gcccggctgg gtgcgcaccg acctggccca ggaccccgag      600

accctcggcg tggaggtcag ggacctcctg gaccccgcgg acatcgccga cgtcgtgctg      660

tgggccatca cccgcccgcc ggcggtcagc atcggcccgc tgatacccgt acgccccgtc      720

agcaggaacg cgcagaccct ggtcaactgg gagcagtacc tgcggacgct gcgccattac      780

gacgcctccg gcggtcacat ggtcgacgtg cccgggatcc ctgaatga                   828


<210>  286
<211>  275
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  286

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Val Ala Arg Arg Lys Glu Gln Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Asp Val Ala Gly His Glu Val Pro Thr Val Thr Leu Val 
    50                  55                  60                  


Ala Asp Leu Ala Ala Asp Gly Ala Pro Lys Asp Met Val Ala Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Arg Thr Gly Pro Ile His Asp Thr His Pro Arg His Trp Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Val Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Thr Leu Gly Val Glu Val Arg Asp 
        195                 200                 205             


Leu Leu Asp Pro Ala Asp Ile Ala Asp Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Asn Ala Gln Thr Leu Val Asn Trp Glu Gln Tyr Leu Arg Thr 
                245                 250                 255     


Leu Arg His Tyr Asp Ala Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  287
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamN polypeptide

<400>  287

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Val Ala Arg Arg Lys Glu Gln Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Asp Leu Ala Gly His Glu Val Pro Thr Val Thr Leu Leu 
    50                  55                  60                  


Ala Asp Leu Ala Ala Asp Gly Ala Pro Lys Asp Met Val Ala Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Gly Arg Thr Gly Pro Ile His Asp Thr His Pro Arg His Phe Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Lys Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Val Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Ser Leu Gly Leu Glu Val Arg Asp 
        195                 200                 205             


Leu Leu Asp Pro Ala Asp Ile Ala Asp Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Gly Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Gln Ala Gln Ser Leu Val Asn Trp Glu Gln Phe Leu Arg Thr 
                245                 250                 255     


Leu Lys His Tyr Glu Ala Ser Gly Gly His Met Val Asp Met Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  288
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamN polypeptide

<400>  288

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Lys Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Ile Ala Arg Arg Lys Glu Asn Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Asp Val Ala Gly His Glu Val Pro Thr Val Thr Leu Val 
    50                  55                  60                  


Ala Asp Leu Gly Ala Asp Gly Ala Pro Lys Asp Met Leu Ala Ala Ala 
65                  70                  75                  80  


Asp Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Arg Thr Gly Pro Ile His Asp Thr His Pro Arg His Trp Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Ile Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Gly Leu Thr Ala Gln Val Asp Leu Glu Asn 
                165                 170                 175     


Lys His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Thr Leu Gly Val Glu Val Arg Asp 
        195                 200                 205             


Leu Leu Asp Pro Ala Asp Ile Ala Asp Leu Val Ile Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Asn Ala Gln Thr Leu Val Asn Phe Glu Gln Tyr Leu Arg Ser 
                245                 250                 255     


Ile Arg His Tyr Asp Ala Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  289
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamN polypeptide

<400>  289

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Lys Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Met Ala Arg Arg Lys Glu Gln Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Glu Val Ala Gly His Glu Val Pro Thr Val Thr Leu Val 
    50                  55                  60                  


Ala Asp Leu Ala Ala Glu Gly Ala Pro Arg Asp Met Ile Ala Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Leu 
                85                  90                  95      


Ala Lys Thr Gly Pro Leu His Asp Thr His Pro Arg His Trp Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Trp Leu Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Lys Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Gly Ser Leu Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Ala Leu Thr Ala Gln Val Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Val Ala Gln Asp Pro Glu Thr Leu Gly Val Glu Leu Arg Asp 
        195                 200                 205             


Leu Ile Asp Pro Ala Asp Ile Ala Glu Val Val Leu Trp Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Met Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Asn Ala Gln Thr Leu Val Asn Trp Glu Gln Tyr Ile Arg Thr 
                245                 250                 255     


Met Arg His Tyr Asp Ala Ser Gly Gly His Met Ile Glu Leu Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  290
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamN polypeptide

<400>  290

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Arg Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Val Ala Arg Arg Lys Glu Gln Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Asp Val Ala Gly His Glu Val Pro Thr Val Thr Leu Leu 
    50                  55                  60                  


Gly Asp Leu Ala Ala Asp Gly Ala Pro Arg Asp Met Val Ala Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Val Leu Val Asn Asn Ala Ala Val 
                85                  90                  95      


Ala Arg Thr Gly Pro Ile His Asp Thr His Pro Arg His Tyr Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Ile Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Ala Ser Val Leu Gln Gly Asp Tyr Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Gly Leu Thr Ala Gln Val Asp Met Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Met Pro Gly Phe Val Arg 
            180                 185                 190         


Thr Asp Met Ala Gln Asp Pro Glu Thr Met Gly Leu Glu Leu Arg Asp 
        195                 200                 205             


Leu Leu Asp Pro Ala Asp Ile Ala Asp Val Val Leu Phe Ala Ile Thr 
    210                 215                 220                 


Lys Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Arg Pro Val 
225                 230                 235                 240 


Ser Arg Gln Ala Gln Thr Met Met Asn Phe Glu Gln Tyr Ile Arg Ser 
                245                 250                 255     


Leu Arg His Tyr Asp Gly Ser Gly Gly His Met Val Asp Val Pro Gly 
            260                 265                 270         


Ile Pro Glu 
        275 


<210>  291
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamN polypeptide

<400>  291

Met Thr Glu Asp Arg Pro Leu Lys Gly Lys Val Ala Leu Val Ala Gly 
1               5                   10                  15      


Ala Ser Ser Gly Ile Gly Ala Ser Ile Ala Lys Thr Leu Ala Gln Ala 
            20                  25                  30          


Gly Ala Ser Val Ala Leu Ile Ala Arg Arg Lys Asp Gln Leu Ala Ser 
        35                  40                  45              


Val Glu Gln Glu Val Gly Gly His Glu Val Pro Thr Val Thr Ile Ile 
    50                  55                  60                  


Ala Asp Leu Ala Ala Asp Gly Ala Pro Lys Asp Met Leu Gly Ala Ala 
65                  70                  75                  80  


Glu Arg Ala Leu Gly Pro Val Asp Ile Leu Val Asn Asn Ala Ala Val 
                85                  90                  95      


Ala Arg Thr Gly Pro Ile His Glu Thr His Pro Lys His Trp Arg His 
            100                 105                 110         


Ala Phe His Leu Asn Leu Asp Val Pro Phe Leu Leu Ala Arg Ser Val 
        115                 120                 125             


Leu Pro Gly Met Arg Glu Arg Gly His Gly Trp Ile Val Asn Ile Ser 
    130                 135                 140                 


Ser Glu Ala Ser Val Leu Gln Ala Asp Trp Ser Ala Pro Tyr Ser Ile 
145                 150                 155                 160 


Thr Lys Arg Ala Leu Asn Gly Leu Thr Ala Gln Val Asp Leu Glu Asn 
                165                 170                 175     


Arg His Leu Gly Val Arg Ala Ile Ala Val Leu Pro Gly Trp Val Arg 
            180                 185                 190         


Thr Asp Leu Ala Gln Asp Pro Glu Thr Leu Gly Val Glu Leu Arg Asp 
        195                 200                 205             


Leu Leu Asp Pro Ala Asp Ile Ala Glu Val Val Val Tyr Ala Ile Thr 
    210                 215                 220                 


Arg Pro Pro Ala Val Ser Ile Gly Pro Leu Ile Pro Val Lys Pro Val 
225                 230                 235                 240 


Ser Arg Asn Ala Gln Ser Leu Leu Gln Phe Glu Gln Phe Leu Arg Thr 
                245                 250                 255     


Val Arg His Tyr Asp Ala Ser Gly Gly His Met Val Asp Leu Pro Gly 
            260                 265                 270         


Ile Pro Asp 
        275 


<210>  292
<211>  1608
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  292
gtgccggacg ccgcgcactg cgtgacgggc gcgctgctcg ccgcccgcgc cctggcccac       60

cccgaccgcg tgtacgccgt cttcgaggac ggcaccgact ggacgtacgg gcaggcgtac      120

gaagacgcgc gtgccaccgc cgcggccctg taccagttgg gcgtgcggca gggcgacacc      180

gtgctgtgct ggctgcccaa cggccttgac gcgctgcgcg tctggtacgg cgtcaatctg      240

ctgggcgccg tccacgtccc cgtcaacacc gcctaccgcg ggggcctgct cgggcatgtg      300

ctcgacaact ccggcgcccg cgtcctggtg gcgcacgcgc tgctcgtcga acggctccag      360

cacacctcgg gcgcccggct ccaggacgtc gtcgtcctcg gcggcggacc ggacgacccg      420

tggcccgacg ccctgcccgg cgccccgcgc gtccacggtc ccgcggcgct gcggggccgg      480

ccggaggact tcgcgccgcc cgagcggccg gtcgcgccct gggacaccat ggcggtgatc      540

tacacctcgg gcaccaccgg cccgtccaag ggcgtcctcg tctcctacgt ccaccactac      600

tcgaccgtga cggcgctgct cgacgacgac atcaccgagc acgaccggta tctgctcaac      660

ctgccgctgt gccacggcgg cggcaccgaa gtggcctact gcatgctcct gtacgggggt      720

tcggtcgtcg tcaccgaggg cttcgggacg agcgagttct gggacgtggt ccgccgacac      780

ggagtgacca tgtgcaccct gctcggcgcc atggtcgatt tcctgctcgg cctgccgccc      840

cacccgggag aggcggacca ccccctgcgg gccgcctgcg tgattccgct gacgcgccag      900

gccctcgact tcggccgccg cttcggcgtg gacgtctaca ccgggttcaa catgtccgag      960

acgtcggcgc ccctggtgtc ggcgctcaat ccgcagcgcg tcggcagctg cgggcgtccg     1020

cgccccgggg tgcagtgccg ggtggtggac gagcacggca tcgacgtacc ggacggcgag     1080

gccggcgagc tggtgctgcg cgccgatcgg ccgtggtcgc tgttccacgg ctaccacggc     1140

atgccggagg ccaccgcggc ggcgtggcgg cacggctggt tccacaccgg ggacgccgtg     1200

gtgcgggagg cggggggcga ctacttcttc gtggaccgca tcaaggacgc catccggcgc     1260

cggggcgaga acgtctcctc ggccgaggtg gagggcgaac tgctcagcca tcccgcggtg     1320

gctctggccg cggccgtggc ggtgcccagc gatctggccg aggacgagat actcgccgcc     1380

ctcgtgctgc ggcccggggt ccggttcgac ccggagcggt tcatcgcgca tctgcggccg     1440

cgcatggccc acttcatggt gccgcgctat ctgcgcgtgc tgtccgagct ccccgtcaca     1500

cagacgggca aggtccgcaa ggagacgctg cgcgcccagg gtgtcactcc cgacacctgg     1560

gaccgggtgg ccgcagggat cgaggtcacc cgtgaccgca tccgctga                  1608


<210>  293
<211>  535
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  293

Met Pro Asp Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Arg Val Tyr Ala Val Phe Glu Asp Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Ala 
        35                  40                  45              


Ala Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Gly Leu 
                85                  90                  95      


Leu Gly His Val Leu Asp Asn Ser Gly Ala Arg Val Leu Val Ala His 
            100                 105                 110         


Ala Leu Leu Val Glu Arg Leu Gln His Thr Ser Gly Ala Arg Leu Gln 
        115                 120                 125             


Asp Val Val Val Leu Gly Gly Gly Pro Asp Asp Pro Trp Pro Asp Ala 
    130                 135                 140                 


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Leu Arg Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Ala Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
        195                 200                 205             


Asp Asp Ile Thr Glu His Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
    210                 215                 220                 


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Glu Gly Phe Gly Thr Ser Glu Phe Trp Asp Val 
                245                 250                 255     


Val Arg Arg His Gly Val Thr Met Cys Thr Leu Leu Gly Ala Met Val 
            260                 265                 270         


Asp Phe Leu Leu Gly Leu Pro Pro His Pro Gly Glu Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Leu Asp Phe 
    290                 295                 300                 


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Leu Val Ser Ala Leu Asn Pro Gln Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Glu His 
            340                 345                 350         


Gly Ile Asp Val Pro Asp Gly Glu Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Val Arg Glu Ala Gly Gly Asp Tyr Phe Phe Val Asp Arg Ile Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Ala Glu Val Glu Gly 
            420                 425                 430         


Glu Leu Leu Ser His Pro Ala Val Ala Leu Ala Ala Ala Val Ala Val 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Arg 
    450                 455                 460                 


Pro Gly Val Arg Phe Asp Pro Glu Arg Phe Ile Ala His Leu Arg Pro 
465                 470                 475                 480 


Arg Met Ala His Phe Met Val Pro Arg Tyr Leu Arg Val Leu Ser Glu 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
            500                 505                 510         


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Gly Ile Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  294
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamL polypeptide

<400>  294

Met Pro Asp Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Arg Val Tyr Ala Val Phe Glu Asp Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Ala 
        35                  40                  45              


Ala Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Gly Leu 
                85                  90                  95      


Leu Gly His Val Leu Asp Asn Ser Gly Ala Arg Val Leu Val Ala His 
            100                 105                 110         


Ala Leu Leu Val Glu Arg Leu Gln His Thr Ser Gly Ala Arg Leu Gln 
        115                 120                 125             


Asp Val Val Val Leu Gly Gly Gly Pro Asp Asp Pro Trp Pro Asp Ala 
    130                 135                 140                 


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Leu Arg Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Ala Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
        195                 200                 205             


Asp Asp Ile Thr Glu His Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
    210                 215                 220                 


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Glu Gly Phe Gly Thr Ser Glu Phe Trp Asp Val 
                245                 250                 255     


Val Arg Arg His Gly Val Thr Met Cys Thr Leu Leu Gly Ala Met Val 
            260                 265                 270         


Asp Phe Leu Leu Gly Leu Pro Pro His Pro Gly Glu Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Leu Asp Phe 
    290                 295                 300                 


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Leu Val Ser Ala Leu Asn Pro Gln Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Glu His 
            340                 345                 350         


Gly Ile Asp Val Pro Asp Gly Glu Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Val Arg Glu Ala Gly Gly Asp Tyr Phe Phe Val Asp Arg Ile Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Ala Glu Val Glu Gly 
            420                 425                 430         


Glu Leu Leu Ser His Pro Ala Val Ala Leu Ala Ala Ala Val Ala Val 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Arg 
    450                 455                 460                 


Pro Gly Val Arg Phe Asp Pro Glu Arg Phe Ile Ala His Leu Arg Pro 
465                 470                 475                 480 


Arg Met Ala His Phe Met Val Pro Arg Tyr Leu Arg Val Leu Ser Glu 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
            500                 505                 510         


Gln Gly Val Thr Pro Asp Thr Trp Asp Arg Val Ala Ala Gly Ile Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  295
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamL polypeptide

<400>  295

Met Pro Asp Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Arg Val Tyr Ala Val Phe Glu Asp Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Ala 
        35                  40                  45              


Ala Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Ile Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Gly Leu 
                85                  90                  95      


Leu Gly His Val Leu Glu Asn Ser Gly Ala Arg Val Leu Val Ala His 
            100                 105                 110         


Ala Leu Leu Val Glu Arg Leu Gln His Thr Ser Gly Ala Arg Leu Gln 
        115                 120                 125             


Asp Ile Leu Val Ile Gly Gly Gly Pro Asp Asp Pro Trp Pro Asp Ala 
    130                 135                 140                 


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Val Arg Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Ala Pro Pro Glu Arg Pro Val Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Ile Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Ser Ala Leu Leu Asp 
        195                 200                 205             


Asp Asp Ile Ser Glu His Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
    210                 215                 220                 


His Gly Ala Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Glu Gly Tyr Gly Thr Thr Glu Phe Trp Glu Leu 
                245                 250                 255     


Val Arg Arg His Gly Val Thr Val Cys Thr Leu Leu Gly Ala Met Val 
            260                 265                 270         


Asp Phe Leu Met Gly Leu Pro Pro His Pro Gly Asp Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Val Asp Phe 
    290                 295                 300                 


Gly Arg Arg Phe Gly Val Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Leu Val Ser Ala Leu Asn Pro Gln Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Glu His 
            340                 345                 350         


Gly Ile Glu Val Pro Asp Gly Glu Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Thr Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Val Arg Glu Ala Gly Gly Asp Tyr Phe Phe Val Asp Arg Leu Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Ala Glu Val Glu Gly 
            420                 425                 430         


Glu Leu Met Ser His Pro Gly Val Ala Leu Ala Ala Ala Val Ala Val 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Glu Glu Ile Leu Ala Ala Leu Val Leu Arg 
    450                 455                 460                 


Pro Gly Val Arg Phe Asp Pro Glu Arg Phe Ile Ala His Leu Arg Pro 
465                 470                 475                 480 


Arg Met Ala His Tyr Met Val Pro Arg Tyr Leu Arg Val Leu Ser Asp 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
            500                 505                 510         


Gln Gly Val Ser Pro Asp Thr Trp Asp Arg Val Ala Ala Gly Leu Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  296
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamL polypeptide

<400>  296

Met Pro Asp Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Lys 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Arg Val Tyr Ala Ile Phe Glu Asp Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Ala 
        35                  40                  45              


Ala Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Ile Glu Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Gly Gly Leu 
                85                  90                  95      


Leu Gly His Val Leu Asp Asn Thr Gly Ala Arg Val Leu Val Ala His 
            100                 105                 110         


Gly Leu Leu Ile Glu Lys Val Gln His Thr Ser Gly Ala Arg Leu Gln 
        115                 120                 125             


Asp Ile Val Val Leu Gly Gly Gly Pro Asp Asp Pro Trp Pro Asp Gly 
    130                 135                 140                 


Leu Pro Gly Gly Pro Arg Val His Ala Pro Ala Ala Leu Arg Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Ala Pro Pro Glu Arg Pro Leu Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Leu Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Leu Leu Ser Tyr Val His His Tyr Ser Thr Met Thr Ala Leu Leu Asp 
        195                 200                 205             


Asp Glu Leu Thr Asp His Asp Arg Tyr Leu Val Asn Met Pro Leu Cys 
    210                 215                 220                 


His Gly Gly Gly Thr Glu Val Ala Tyr Cys Met Leu Leu Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Glu Gly Phe Gly Thr Ser Asp Phe Trp Asp Val 
                245                 250                 255     


Val Arg Lys His Gly Val Thr Met Cys Thr Leu Leu Gly Ala Val Val 
            260                 265                 270         


Asp Trp Leu Leu Gly Leu Pro Pro His Pro Gly Glu Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Ala Cys Val Ile Pro Leu Thr Arg Gln Ala Leu Asp Phe 
    290                 295                 300                 


Gly Arg Arg Phe Gly Ile Asp Val Tyr Thr Gly Phe Asn Met Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Leu Val Ser Ala Leu Asn Pro Gln Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Lys Val Val Asp Glu His 
            340                 345                 350         


Gly Ile Asp Val Pro Asp Gly Glu Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Val Arg Glu Ala Gly Gly Asp Tyr Trp Phe Val Asp Arg Ile Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Gly Glu Val Glu Ala 
            420                 425                 430         


Glu Leu Leu Ser His Pro Ala Val Ala Leu Ala Ala Ala Val Ala Val 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Asp Glu Ile Leu Ala Ala Leu Val Leu Arg 
    450                 455                 460                 


Pro Gly Val Arg Phe Glu Pro Glu Lys Phe Ile Ala His Leu Arg Pro 
465                 470                 475                 480 


Lys Met Ala His Phe Met Val Pro Lys Tyr Leu Arg Leu Leu Ser Glu 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
            500                 505                 510         


Gln Gly Val Thr Pro Asp Thr Tyr Asp Arg Val Ala Ala Gly Leu Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  297
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamL polypeptide

<400>  297

Met Pro Asp Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Lys Val Tyr Ala Val Phe Asp Asp Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Gly 
        35                  40                  45              


Gly Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Ala Gly Leu 
                85                  90                  95      


Leu Gly His Val Leu Asp Asn Thr Gly Ala Lys Val Leu Val Ala His 
            100                 105                 110         


Ala Leu Leu Val Glu Arg Ile Gln His Thr Ser Gly Gly Arg Leu Gln 
        115                 120                 125             


Asp Leu Leu Val Leu Gly Gly Gly Pro Glu Asp Pro Phe Pro Asp Ala 
    130                 135                 140                 


Leu Pro Gly Ala Pro Arg Leu His Gly Pro Ala Ala Leu Arg Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Ala Pro Pro Glu Arg Pro Leu Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Met Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Leu Val Ser Tyr Val His His Tyr Ser Thr Val Thr Ala Leu Leu Asp 
        195                 200                 205             


Glu Glu Leu Thr Asp His Asp Arg Tyr Leu Leu Asn Leu Pro Leu Cys 
    210                 215                 220                 


His Ala Ala Gly Thr Asp Val Ala Tyr Cys Met Leu Leu Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Asp Gly Tyr Gly Ser Ser Glu Phe Trp Glu Val 
                245                 250                 255     


Val Arg Arg His Gly Val Thr Ile Cys Thr Leu Leu Gly Ala Leu Val 
            260                 265                 270         


Asp Phe Leu Leu Ala Leu Pro Pro His Pro Gly Glu Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Ala Cys Val Ile Pro Leu Ser Arg Gln Ala Leu Asp Phe 
    290                 295                 300                 


Ala Lys Arg Phe Gly Val Asp Val Phe Thr Gly Phe Asn Met Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Met Ile Ser Ala Leu Asn Pro Asn Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Asn Cys Lys Val Leu Asp Glu His 
            340                 345                 350         


Gly Ile Asp Val Pro Glu Gly Glu Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Ser Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Val Arg Glu Ala Gly Gly Asp Tyr Tyr Phe Ile Asp Arg Ile Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Gly Glu Val Glu Ala 
            420                 425                 430         


Glu Leu Leu Ser His Pro Gly Val Ala Leu Ala Ala Ala Val Ala Val 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Glu Glu Ile Leu Ala Ala Leu Val Val Arg 
    450                 455                 460                 


Pro Gly Val Arg Phe Glu Pro Glu Arg Phe Met Ala His Leu Arg Pro 
465                 470                 475                 480 


Arg Met Ala His Phe Met Ile Pro Arg Tyr Leu Arg Val Leu Ser Glu 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Arg Ala 
            500                 505                 510         


Gln Ala Val Thr Pro Glu Thr Trp Asp Arg Val Gly Ala Gly Ile Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  298
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamL polypeptide

<400>  298

Met Pro Glu Ala Ala His Cys Val Thr Gly Ala Leu Leu Ala Ala Arg 
1               5                   10                  15      


Ala Leu Ala His Pro Asp Arg Val Tyr Ala Ile Phe Asp Glu Gly Thr 
            20                  25                  30          


Asp Trp Thr Tyr Gly Gln Ala Tyr Glu Asp Ala Arg Ala Thr Ala Gly 
        35                  40                  45              


Ala Leu Tyr Gln Leu Gly Val Arg Gln Gly Asp Thr Val Leu Cys Trp 
    50                  55                  60                  


Leu Pro Asn Gly Leu Asp Ala Leu Arg Val Trp Tyr Gly Val Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Val His Val Pro Val Asn Thr Ala Tyr Arg Ala Gly Leu 
                85                  90                  95      


Leu Gly His Ile Leu Asp Asn Ser Gly Ala Arg Val Leu Val Ala His 
            100                 105                 110         


Ala Leu Leu Val Asp Arg Leu Gln His Thr Thr Gly Ala Arg Leu Gln 
        115                 120                 125             


Glu Ile Val Val Leu Gly Gly Gly Pro Asp Glu Pro Tyr Pro Asp Ala 
    130                 135                 140                 


Leu Pro Gly Ala Pro Arg Val His Gly Pro Ala Ala Ile Lys Gly Arg 
145                 150                 155                 160 


Pro Glu Asp Phe Gly Pro Pro Asp Arg Pro Val Ala Pro Trp Asp Thr 
                165                 170                 175     


Met Ala Val Val Tyr Thr Ser Gly Thr Thr Gly Pro Ser Lys Gly Val 
            180                 185                 190         


Met Val Ser Tyr Val His His Tyr Ser Thr Val Thr Gly Leu Leu Asp 
        195                 200                 205             


Asp Asp Leu Thr Glu His Asp Arg Tyr Leu Leu Asn Met Pro Leu Cys 
    210                 215                 220                 


His Ala Gly Gly Thr Glu Val Ala Phe Cys Met Leu Ile Tyr Gly Gly 
225                 230                 235                 240 


Ser Val Val Val Thr Asp Gly Tyr Gly Thr Ser Glu Phe Trp Asp Val 
                245                 250                 255     


Val Arg Arg His Gly Val Thr Met Cys Ser Leu Leu Gly Ala Met Val 
            260                 265                 270         


Glu Phe Leu Leu Gly Leu Pro Pro His Pro Ala Glu Ala Asp His Pro 
        275                 280                 285             


Leu Arg Ala Gly Cys Val Ile Pro Leu Ser Arg Gln Ala Leu Asp Phe 
    290                 295                 300                 


Gly Arg Arg Phe Gly Met Asp Val Tyr Thr Gly Phe Asn Val Ser Glu 
305                 310                 315                 320 


Thr Ser Ala Pro Ile Val Ser Ala Leu Asn Pro Gln Arg Val Gly Ser 
                325                 330                 335     


Cys Gly Arg Pro Arg Pro Gly Val Gln Cys Arg Val Val Asp Asp His 
            340                 345                 350         


Gly Val Asp Val Pro Asp Gly Asp Ala Gly Glu Leu Val Leu Arg Ala 
        355                 360                 365             


Asp Arg Pro Trp Thr Leu Phe His Gly Tyr His Gly Met Pro Glu Ala 
    370                 375                 380                 


Thr Ala Ala Ala Trp Arg His Gly Trp Phe His Thr Gly Asp Ala Val 
385                 390                 395                 400 


Leu Arg Glu Ala Gly Gly Glu Tyr Tyr Phe Val Asp Arg Ile Lys Asp 
                405                 410                 415     


Ala Ile Arg Arg Arg Gly Glu Asn Val Ser Ser Ala Glu Val Glu Gly 
            420                 425                 430         


Glu Leu Ile Ser His Pro Ala Val Ala Leu Ala Ala Ala Val Ala Ile 
        435                 440                 445             


Pro Ser Asp Leu Ala Glu Glu Glu Ile Leu Ala Ala Leu Val Leu Lys 
    450                 455                 460                 


Pro Gly Val Arg Phe Asp Pro Asp Arg Phe Ile Ala His Leu Arg Pro 
465                 470                 475                 480 


Lys Met Ala His Trp Met Met Pro Arg Tyr Leu Arg Val Leu Ser Glu 
                485                 490                 495     


Leu Pro Val Thr Gln Thr Gly Lys Val Arg Lys Glu Thr Leu Lys Ala 
            500                 505                 510         


Gln Gly Leu Thr Pro Asp Ser Trp Asp Arg Ile Ala Ala Gly Ile Glu 
        515                 520                 525             


Val Thr Arg Asp Arg Ile Arg 
    530                 535 


<210>  299
<211>  1347
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  299
gtgatcgacc ccgctgacta cgccctgtgg aacagtggcg tgccgcgccc gtacctgaac       60

gcactgtccc gcgacgacct gctcgccgag tccgacggcg tgcgcgtccg tgactccggc      120

ggacgctggt acctggacgg ccgctccgga ctgtggaacg tgacgctggg ctacggcaac      180

acgcgcgtca aggaagccat caagcagcag gtggacaagc tgccgttcgc gaacagctac      240

ggctacggac gccccgccca ggtcaccgtg gactgcgccg aggccctcgt cggccacctg      300

cccgagggca tcaaccacgt ccggttcgcc agcaacggcg cccaggcggt ggagatggcc      360

ctgcagctct cccgcttcct caggctgcgc gccggacagc ccgagcgcat ggccgtgttc      420

gcgatgtggg acggcttcca cgggcagggc cccggcgccg gcatggtgac cggtgtcccg      480

tacctgcacc accagaccgg ccccatgctc cccgaggtgc accacgcccc cgggccgttc      540

tccgtgggcg cgacgccggg cgtcagcgac atggagcggc tcatcaccga attcggcccg      600

gagcgggtga ccgcggtgat cgtggagccc gtggtgggcg agggcgggca catcctgtcc      660

cccgagtacg tgggctccct cgcccggttc tgccgggagc acgacatcca cctggtcttc      720

gacgaggtcg tcaccggcat gggccgcgtc ggcgacttca cccgcgtcgg ccaactgccc      780

gacgtcaccc ccgacatcat caccctgggc aagggcatca cctcggggta cgtgccgatg      840

tcggccgtcg ccatccacga ccgcctctac gaccagctgg cggagcggac cacgggcgac      900

accgcgctca gcgtcggctc gaccaacgac ggtcacgcgg tggccgcggc ggccgccctc      960

gcggtgatcg gggccctcac cgaggacggc gtcctcgaga acgtacgccg ccgtgaggcg     1020

gacctcctgg ccgccctggc caagctccag gcccagcacc ccgagttgac gggcttccgc     1080

tgcctgggcc tgttctgcgg cctggagctc ggcgagcccg gcggtccttc gtggtccccg     1140

ggcaaggtga acaagctgcg catggccctg gagagccggg gcgtgctcag ctccagcctg     1200

cgcgtcgtgc ccaatctgat gctcatgccg ccgctcgtca tcacggagga cgacgtggcg     1260

gagatagccg gcgcgctcga cggcgcgctc accgatgtga agtcgggccg gctgcccgag     1320

tccggcttcg ccaaggccat gggatga                                         1347


<210>  300
<211>  448
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  300

Met Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Asn Ala Leu Ser Arg Asp Asp Leu Leu Ala Glu Ser Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Asp Lys Leu Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Gly His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Val Gly Ala Thr Pro Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ala Ala Leu Ala Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Thr Gly Phe Arg Cys Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Gly Lys Val Asn 
    370                 375                 380                 


Lys Leu Arg Met Ala Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Gly Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Gly Arg Leu Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  301
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamX polypeptide

<400>  301

Met Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Asn Ala Leu Ser Arg Asp Asp Val Leu Ala Glu Ser Asp 
            20                  25                  30          


Gly Ile Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Ile Trp Gln Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Asp Lys Met Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Gly His Val Pro Glu Gly Leu Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Tyr Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Val Gly Ala Thr Pro Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Leu 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Ile Ser Pro Glu Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Met Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Leu Pro Met Ser Ala Val Ala Ile His Asp Lys 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Leu Ala Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Asp Asp Gly Val Leu Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ala Gly Leu Ala Lys Ile Gln Ala Gln 
            340                 345                 350         


His Pro Glu Val Thr Gly Phe Arg Cys Ile Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Gly Lys Val Asn 
    370                 375                 380                 


Lys Met Arg Met Ala Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Ile 
385                 390                 395                 400 


Arg Val Val Pro Gln Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Gly Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Gly Arg Leu Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  302
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamX polypeptide

<400>  302

Met Ile Asp Pro Ala Asp Tyr Ala Leu Phe Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Asn Ala Leu Ser Arg Asp Asp Val Leu Ala Glu Ser Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Ile Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Asp Ala Val Lys Gln Gln Val Asp Arg Leu Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Pro Ala Gln Val Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Gly His Leu Pro Glu Gly Ile Gln His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Leu Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Val Gly Ala Thr Pro Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Gly Gly His Ile Val Ser Pro Glu Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Asp Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Glu Arg Thr Ser Gly Asp Thr Ala Met Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Leu Glu Asn Val Arg 
                325                 330                 335     


Lys Arg Glu Ala Asp Leu Ile Ala Gly Leu Ala Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Leu Thr Gly Phe Arg Cys Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Gly Lys Leu Asn 
    370                 375                 380                 


Arg Leu Arg Met Ala Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Ile Pro Pro Leu Ile Ile Thr Asp 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Gly Ala Leu Glu Gly Ala Leu Thr Glu 
            420                 425                 430         


Val Lys Ser Gly Arg Leu Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  303
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamX polypeptide

<400>  303

Met Ile Asp Pro Ala Asp Tyr Ala Val Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Met Asn Ala Leu Thr Arg Asp Asp Leu Val Ala Glu Ser Asp 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Ile Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Leu Lys Gln Gln Val Asp Arg Leu Pro Phe Ala Asn Ser Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Leu Thr Val Asp Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Gly His Leu Pro Glu Gly Ile Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Ile Ser Arg Phe Leu Arg 
        115                 120                 125             


Val Arg Ala Gly Asn Pro Glu Arg Met Ala Val Phe Ala Met Trp Asp 
    130                 135                 140                 


Gly Phe His Gly Gln Gly Pro Gly Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Val His His Gln Thr Gly Pro Val Leu Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Val Gly Ala Thr Pro Gly Val Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Val Gly Glu Ala Gly His Val Met Ser Pro Asp Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Phe Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Val Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Glu Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Asp Arg Ser Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Val Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Leu Leu Glu Gln Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ala Gly Leu Ala Lys Leu Gln Ala Asn 
            340                 345                 350         


His Pro Glu Leu Thr Gly Phe Arg Cys Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Gly Gly Pro Ser Trp Ser Pro Ala Lys Val Asn 
    370                 375                 380                 


Lys Leu Arg Met Ala Leu Glu Ser Arg Gly Val Ile Ser Thr Ser Leu 
385                 390                 395                 400 


Arg Val Val Pro Asn Leu Met Leu Val Pro Pro Leu Ile Ile Thr Glu 
                405                 410                 415     


Asp Asp Val Ala Glu Ile Ala Ala Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Met Lys Ser Gly Arg Leu Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  304
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamX polypeptide

<400>  304

Met Ile Asp Pro Ala Asp Tyr Ala Ile Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Asn Ala Ile Ser Arg Asp Asp Leu Val Ala Glu Ser Glu 
            20                  25                  30          


Gly Ile Arg Val Arg Asp Ser Gly Gly Arg Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Leu Trp Asn Val Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Asp Ala Ile Lys Gln Gln Val Asp Lys Val Pro Phe Gly Asn Ser Tyr 
65                  70                  75                  80  


Gly Phe Gly Arg Pro Ala Gln Ile Ser Ile Glu Cys Ala Glu Ala Leu 
                85                  90                  95      


Val Gly His Leu Pro Glu Gly Leu Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Leu Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Gly Met Trp Asp 
    130                 135                 140                 


Ala Phe His Gly Asn Gly Pro Ala Ala Gly Met Val Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Ile His His Gln Thr Gly Pro Leu Met Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Val Ala Ala Ser Pro Gly Leu Ser Asp Met Glu 
            180                 185                 190         


Arg Leu Ile Thr Glu Phe Gly Pro Glu Arg Val Thr Ala Val Ile Met 
        195                 200                 205             


Glu Pro Val Val Gly Glu Ala Gly His Leu Met Ser Pro Glu Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Val Thr Gly Met Gly Arg Val Gly Asp Trp Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Val Pro Met Ser Ala Val Ala Ile His Glu Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Glu Lys Thr Thr Gly Asp Thr Ala Leu Thr 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Leu Ala Ala Ala Ala Ala Leu 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Val Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ala Ala Leu Ala Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Asp Leu Thr Gly Phe Arg Cys Leu Gly Leu Phe Cys Gly Leu 
        355                 360                 365             


Glu Leu Gly Asp Pro Gly Gly Pro Ser Trp Ser Pro Ala Lys Val Asn 
    370                 375                 380                 


Arg Val Arg Met Ala Leu Glu Ser Arg Gly Val Leu Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Ile Pro Asn Leu Met Leu Met Pro Pro Leu Ile Met Thr Asp 
                405                 410                 415     


Glu Asp Val Ala Glu Ile Ala Ala Ala Leu Asp Gly Ala Leu Thr Asp 
            420                 425                 430         


Val Lys Ser Gly Arg Leu Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  305
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamX polypeptide

<400>  305

Met Ile Asp Pro Ala Asp Tyr Ala Leu Trp Asn Ser Gly Val Pro Arg 
1               5                   10                  15      


Pro Tyr Leu Asn Ala Leu Ser Lys Asp Asp Ile Val Gly Glu Ser Glu 
            20                  25                  30          


Gly Val Arg Val Arg Asp Ser Ala Gly Lys Trp Tyr Leu Asp Gly Arg 
        35                  40                  45              


Ser Gly Met Trp Asn Leu Thr Leu Gly Tyr Gly Asn Thr Arg Val Lys 
    50                  55                  60                  


Glu Ala Ile Lys Gln Gln Val Asp Lys Leu Pro Phe Ala Asn Thr Tyr 
65                  70                  75                  80  


Gly Tyr Gly Arg Pro Ala Gln Val Thr Val Glu Cys Ala Glu Gly Leu 
                85                  90                  95      


Val Gly His Val Pro Glu Gly Leu Asn His Val Arg Phe Ala Ser Asn 
            100                 105                 110         


Gly Ala Gln Ala Val Glu Met Ala Leu Gln Ile Ser Arg Phe Leu Arg 
        115                 120                 125             


Leu Arg Ala Gly Gln Pro Glu Arg Met Ala Val Phe Ala Ile Trp Glu 
    130                 135                 140                 


Ala Phe His Gly Gln Gly Pro Ala Ala Gly Met Leu Thr Gly Val Pro 
145                 150                 155                 160 


Tyr Leu His His Gln Thr Gly Pro Met Met Pro Glu Val His His Ala 
                165                 170                 175     


Pro Gly Pro Phe Ser Leu Gly Ala Thr Pro Gly Val Ser Glu Met Glu 
            180                 185                 190         


Lys Leu Ile Thr Glu Phe Gly Pro Glu Arg Ile Thr Ala Val Ile Val 
        195                 200                 205             


Glu Pro Val Leu Gly Glu Gly Gly His Ile Leu Ser Pro Glu Tyr Val 
    210                 215                 220                 


Gly Ser Leu Ala Arg Phe Cys Arg Glu His Asp Ile His Leu Val Phe 
225                 230                 235                 240 


Asp Glu Val Leu Thr Gly Met Gly Arg Val Gly Asp Tyr Thr Arg Val 
                245                 250                 255     


Gly Gln Leu Pro Asp Val Thr Pro Asp Ile Ile Thr Leu Gly Lys Gly 
            260                 265                 270         


Ile Thr Ser Gly Tyr Met Pro Met Ser Ala Val Ala Ile His Glu Arg 
        275                 280                 285             


Leu Tyr Asp Gln Leu Ala Glu Arg Thr Thr Gly Asp Thr Ala Leu Ser 
    290                 295                 300                 


Val Gly Ser Thr Asn Asp Gly His Ala Leu Ala Ala Ala Ala Ala Val 
305                 310                 315                 320 


Ala Val Ile Gly Ala Leu Thr Glu Asp Gly Val Ile Glu Asn Val Arg 
                325                 330                 335     


Arg Arg Glu Ala Asp Leu Leu Ala Gly Leu Ala Lys Leu Gln Ala Gln 
            340                 345                 350         


His Pro Glu Ile Thr Gly Phe Arg Cys Leu Gly Leu Phe Cys Ala Leu 
        355                 360                 365             


Glu Leu Gly Glu Pro Ala Gly Pro Ser Trp Ser Pro Gly Lys Val Asn 
    370                 375                 380                 


Lys Leu Arg Met Ala Leu Glu Ser Arg Gly Val Val Ser Ser Ser Leu 
385                 390                 395                 400 


Arg Val Leu Pro Asn Leu Met Leu Met Pro Pro Leu Val Ile Thr Glu 
                405                 410                 415     


Glu Asp Val Ala Glu Ile Ala Ala Ala Leu Glu Gly Ala Leu Thr Glu 
            420                 425                 430         


Leu Lys Ser Gly Arg Ile Pro Glu Ser Gly Phe Ala Lys Ala Met Gly 
        435                 440                 445             


<210>  306
<211>  822
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  306
gtgagtgacg agatggccag tcagcacacc ggtcgcaaga ccagcaagca gtggcaggaa       60

gaggcggcgg aggagtggga ccgctacgcc gacatctggg acagctggac gcccgacgac      120

agccgggacg acgcggagga ggccgcggac ttcctcgcgg ctctcgccaa gggcggcacg      180

gccctggaac tcggcatcgg gacgggccgc gtggcgctcc cgctggcgca gcgcggggtg      240

cgggtgagcg gcatcgacgc ctcgccgaag atgctgcaga agctcaagga gaagcccggc      300

ggggaccaga tcgtggcctt cgagggcaac ttcgccgacg tcgacgtcga ggaggagtac      360

gacgtcgtct tcatcgccct cgccacgctg ttcgtcctgc ccgaccagga cgagcaggcg      420

cgctgcctcg ccaacagcgc caagcggctc aagcccggcg ggcgggtcgt cgtccagaac      480

atcgtgccgg acatgacgta ctaccagcgc ggtcggcaga acgactacgg catgactgag      540

ccgttccgca tctccggccg cctggccggg cacccgcggc tcgcctggtt cgagatgaac      600

cacgtcgacc cgacgacgca gatggtcaag cgcacggacg tcatcatgag cgagaagggc      660

aaccgcatca tcgcggcgac catgcgcttc gtgtggccct ccgagcagga cctgatggcc      720

cgtctgggcg gtctggaact ggaggaccgc tggggcggct ggcgcaagga gccgttccac      780

tacgacagca gggacgcggt gtccgtctac cgcaagcagt ga                         822


<210>  307
<211>  273
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  307

Met Ser Asp Glu Met Ala Ser Gln His Thr Gly Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Asp Gln Ile Val Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Glu Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Val Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Asp Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Ser Glu Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Glu Leu Glu Asp Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  308
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamY polypeptide

<400>  308

Met Ser Asp Glu Met Ala Thr Gln His Thr Gly Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Lys Tyr Ala Asp Leu 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Asn Lys Gly Val 
65                  70                  75                  80  


Arg Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Glu Gln Ile Val Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Glu Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Glu Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Val Val Val Asn Asn 
145                 150                 155                 160 


Ile Val Pro Asp Met Ser Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Val Ser Gly Lys Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Thr Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Val Met Ser Glu Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Glu Val Glu Asp Arg Tyr Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  309
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamY polypeptide

<400>  309

Met Ser Asp Glu Met Ala Ser Gln His Thr Ala Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Leu Ala Lys Gly Ala Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Leu Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Ala Asp Gln Ile Val Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Asp Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Lys Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Val Val Val Gln Asn 
145                 150                 155                 160 


Ile Ile Pro Asp Ile Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Ile Thr Glu Pro Phe Arg Ile Ser Ala Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Leu Ala Trp Phe Glu Met Asn His Val Asp Pro Thr Ser Gln Ile 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Met Ser Glu Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Glu Leu Glu Glu Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Trp His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  310
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamY polypeptide

<400>  310

Met Ser Asp Glu Met Ala Ser Gln His Thr Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Lys Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Tyr Thr Pro Asp Asp Ser Arg Asp Asp Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Leu Ala Lys Gly Gly Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Val Pro Leu Ala Gln Lys Gly Val 
65                  70                  75                  80  


Lys Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Asp Gln Ile Val Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Glu Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Lys Val Val Val Gln Asn 
145                 150                 155                 160 


Ile Val Pro Glu Met Thr Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Met Thr Glu Pro Tyr Arg Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Ile Ala Trp Trp Glu Met Asn His Val Glu Pro Thr Ser Gln Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Leu Leu Ser Glu Lys Gly Asn Arg Leu Ile 
    210                 215                 220                 


Ala Ala Ser Met Arg Phe Val Trp Pro Ser Glu Gln Asp Val Met Ala 
225                 230                 235                 240 


Lys Leu Gly Gly Leu Glu Leu Glu Glu Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  311
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamY polypeptide

<400>  311

Met Ser Asp Glu Met Ala Thr Gln His Ser Gly Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Trp Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Tyr Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Phe Thr Pro Asp Glu Ser Lys Asp Asp Ala Asp Asp Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Ile Ala Lys Gly Ala Ser Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Leu Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Lys Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Gly Asp Gln Ile Val Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Glu Val Asp Val Glu Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Ala 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Val Val Val Asn Asn 
145                 150                 155                 160 


Ile Val Pro Glu Leu Thr Tyr Tyr Gln Arg Ala Arg Gln Asn Asp Phe 
                165                 170                 175     


Gly Met Thr Glu Pro Phe Arg Ile Ser Gly Arg Leu Ala Gly His Pro 
            180                 185                 190         


Arg Val Ala Trp Phe Glu Ile Asn His Val Asp Pro Ser Thr Gln Ile 
        195                 200                 205             


Val Lys Arg Thr Asp Val Ile Leu Ser Asp Lys Gly Asn Arg Ile Ile 
    210                 215                 220                 


Gly Ala Thr Met Arg Trp Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Lys Leu Gly Gly Leu Glu Met Glu Asp Arg Trp Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  312
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamY polypeptide

<400>  312

Met Ser Asp Glu Met Ala Ser Gln His Thr Gly Arg Lys Thr Ser Lys 
1               5                   10                  15      


Gln Tyr Gln Glu Glu Ala Ala Glu Glu Trp Asp Arg Phe Ala Asp Ile 
            20                  25                  30          


Trp Asp Ser Trp Thr Pro Glu Asp Ser Lys Glu Glu Ala Glu Glu Ala 
        35                  40                  45              


Ala Asp Phe Leu Ala Ala Ile Ala Lys Gly Ala Thr Ala Leu Glu Leu 
    50                  55                  60                  


Gly Ile Gly Thr Gly Arg Val Ala Leu Pro Leu Ala Gln Arg Gly Val 
65                  70                  75                  80  


Arg Val Ser Gly Ile Asp Ala Ser Pro Lys Met Leu Gln Lys Leu Lys 
                85                  90                  95      


Glu Lys Pro Gly Ala Glu Asn Ile Leu Ala Phe Glu Gly Asn Phe Ala 
            100                 105                 110         


Asp Val Asp Val Glu Glu Glu Tyr Asp Val Val Phe Ile Ala Leu Gly 
        115                 120                 125             


Thr Leu Phe Val Leu Pro Asp Gln Asp Glu Gln Ala Arg Cys Leu Ala 
    130                 135                 140                 


Asn Ser Ala Lys Arg Leu Lys Pro Gly Gly Arg Val Val Val Gln Gln 
145                 150                 155                 160 


Ile Val Pro Glu Leu Ser Tyr Tyr Gln Arg Gly Arg Gln Asn Asp Tyr 
                165                 170                 175     


Gly Val Thr Glu Pro Phe Lys Ile Ser Gly Lys Leu Ala Gly His Pro 
            180                 185                 190         


Arg Met Ala Trp Tyr Glu Met Asn His Leu Asp Pro Thr Thr Asn Met 
        195                 200                 205             


Val Lys Arg Thr Asp Val Leu Met Ser Glu Lys Ala Asn Arg Ile Val 
    210                 215                 220                 


Ala Ala Thr Met Arg Phe Val Trp Pro Ser Glu Gln Asp Leu Met Ala 
225                 230                 235                 240 


Arg Leu Gly Gly Leu Glu Leu Glu Asp Arg Tyr Gly Gly Trp Arg Lys 
                245                 250                 255     


Glu Pro Phe His Tyr Asp Ser Arg Asp Ala Val Ser Val Tyr Arg Lys 
            260                 265                 270         


Gln 
    


<210>  313
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequence of pamS from S. alboniger and S. aurantiacus

<400>  313
atgagcgaag agttcgggca ggatcgtccg gccgaagcgg gcagcgggag cggcacggac       60

gtgctcgtcg agcgccgcgg ccccgtgctc gtgatccaac tgaaccggcc gcgcgtacgc      120

aacgcgctga cccgcgccat ggccgaacgg ctcgccgccg ccttcacgga actggatgcc      180

cgagcggagc tgcgtctcgg cgtcctgacc ggcaccccgc cggcgttctg ctccggcatg      240

gacctcgggg ccttcgcccg cggggagcgc gcctccctgc cggggcgtgg cttcggcggt      300

ctgacggagc agccgccgag caagccgctg atcgccgccg tggagggtgc ggcggtcggc      360

ggtggtttcg agatggtgct cgcctgcgac atggtggtgg cggcggacga cgcggtgttc      420

gggctgcccg agctgcgccg agggctggtg gcggcggccg gcggtctgct gcggctgccg      480

cgcgcgatcg cgcccgccgt ggcgatggag atggctctga ccggcgagcc gatcgacgcc      540

cagcgcgcct tttcgctggg gctcgtcaac cgcgtcgtgc ccgcggggac ggcgctggcg      600

gccgcctgtg agctcgggga gaagatcgcc gcgcacgcgg accacgctgt cctcgcgagc      660

aaggccgtcc tcgcccgggc acgcgacgga gagctcgccg acgagtaccg ggctcatcgc      720

gagttgctgt ccgacatcat cgattccccc ggcgcgcgcg ccggggcacg cgacttcgtc      780

caagggcgtt cgggtggaac aggatga                                          807


<210>  314
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric sequence of pamS from S. alboniger and S. aurantiacus

<400>  314

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Leu Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Gly Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Met Val Val Ala Ala Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Leu Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Pro Ala Gly Thr Ala Leu Ala Ala Ala Cys Glu Leu Gly Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Ala Val Leu 
    210                 215                 220                 


Ala Arg Ala Arg Asp Gly Glu Leu Ala Asp Glu Tyr Arg Ala His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Asp Ile Ile Asp Ser Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Val Gln Gly Arg Ser Gly Gly Thr Gly 
            260                 265             


<210>  315
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamS polypeptide

<400>  315

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Ala 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Asp Arg Leu Ala Ala Ala Phe Thr Glu Val Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Gly Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Leu Val Val Ala Gly Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Ile Arg Arg Gly Leu Val Ala Gly Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Asp 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Leu Gly Leu Val Asn Lys Val 
            180                 185                 190         


Val Pro Ala Gly Thr Ala Leu Ala Ala Ala Cys Asp Leu Gly Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Leu Leu Ala Ser Lys Ala Val Leu 
    210                 215                 220                 


Ala Arg Ala Arg Asp Gly Glu Leu Ala Asp Glu Tyr Arg Ala His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Asp Ile Ile Glu Ser Pro Gly Ala Lys Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Val Gln Gly Arg Ser Gly Ala Thr Gly 
            260                 265             


<210>  316
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamS polypeptide

<400>  316

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Leu Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Glu Leu Asp Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Ser Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Tyr Gly Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Met Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Ile Val Val Ala Ala Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Leu Arg Arg Gly Leu Met Ala Ala Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Leu Asp Met Ala Leu Ser Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Pro Ala Ala Thr Ala Leu Ala Ala Ala Cys Glu Leu Gly Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Ala Val Leu 
    210                 215                 220                 


Ala Arg Ala Arg Asp Gly Glu Leu Ala Asp Glu Tyr Lys Ala His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Asp Ile Val Asp Thr Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Leu Gln Gly Arg Ser Gly Gly Thr Gly 
            260                 265             


<210>  317
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamS polypeptide

<400>  317

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Leu Val Glu Arg Arg Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Glu Arg Leu Ala Ala Ala Phe Thr Asp Val Asp Ala Arg Ala Asp Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Lys Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Ala Gly Leu Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Leu Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Ile Val Val Ala Ala Asp Asp Ala Val Phe Gly Met Pro Glu 
    130                 135                 140                 


Val Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Leu Ile Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Ala Val Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Leu Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Pro Ala Gly Thr Ala Leu Ala Ala Ala Cys Asp Leu Gly Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Met Leu Ala Ser Lys Ala Val Leu 
    210                 215                 220                 


Ala Arg Gly Arg Asp Gly Asp Leu Ala Asp Glu Tyr Arg Ala His Arg 
225                 230                 235                 240 


Glu Leu Val Ser Glu Leu Leu Asp Ser Pro Gly Ala Lys Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Val Gln Gly Arg Ser Gly Gly Thr Gly 
            260                 265             


<210>  318
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamS polypeptide

<400>  318

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Ala 
1               5                   10                  15      


Ser Ala Thr Asp Val Ile Ile Glu Arg Arg Gly Pro Val Leu Leu Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Arg Asn Ala Leu Thr Lys Ala Val Ala 
        35                  40                  45              


Asp Arg Leu Ala Ala Ala Phe Thr Asp Leu Glu Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Gly Ala Phe Ala Arg Gly Asp Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Gly Phe Gly Gly Leu Thr Glu Gln Pro Pro Thr Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Ile Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Ile Val Val Ala Ala Asp Asp Ala Val Phe Gly Leu Pro Glu 
    130                 135                 140                 


Leu Arg Arg Gly Leu Val Ala Ala Ala Gly Gly Leu Leu Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Gly Ile Ala Met Glu Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Met Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Pro Ala Gly Thr Ala Val Ala Ala Ala Cys Glu Leu Gly Glu Lys 
        195                 200                 205             


Ile Ala Ala His Ala Asp His Ala Val Leu Ala Ser Lys Ala Leu Leu 
    210                 215                 220                 


Ala Arg Ala Arg Asp Gly Glu Ile Ala Glu Glu Tyr Arg Ala His Arg 
225                 230                 235                 240 


Glu Leu Leu Thr Asp Leu Leu Asp Thr Pro Gly Ala Lys Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Leu Gln Gly Arg Ser Gly Gly Thr Gly 
            260                 265             


<210>  319
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamS polypeptide

<400>  319

Met Ser Glu Glu Phe Gly Gln Asp Arg Pro Ala Glu Ala Gly Ser Gly 
1               5                   10                  15      


Ser Gly Thr Asp Val Val Leu Glu Arg Lys Gly Pro Val Leu Val Ile 
            20                  25                  30          


Gln Leu Asn Arg Pro Arg Val Lys Asn Ala Leu Thr Arg Ala Met Ala 
        35                  40                  45              


Asp Arg Leu Ala Ala Ala Phe Thr Glu Ile Glu Ala Arg Ala Glu Leu 
    50                  55                  60                  


Arg Leu Gly Val Leu Thr Gly Thr Pro Pro Ala Phe Cys Ser Gly Met 
65                  70                  75                  80  


Asp Leu Ala Ala Phe Ala Arg Gly Glu Arg Ala Ser Leu Pro Gly Arg 
                85                  90                  95      


Ala Phe Gly Gly Ile Thr Glu Gln Pro Pro Ser Lys Pro Leu Ile Ala 
            100                 105                 110         


Ala Val Glu Gly Ala Ala Val Gly Gly Gly Phe Glu Met Val Leu Ala 
        115                 120                 125             


Cys Asp Ile Val Val Ala Ala Asp Asp Ala Val Phe Ala Leu Pro Glu 
    130                 135                 140                 


Ile Arg Arg Gly Leu Val Ala Gly Ala Gly Gly Val Met Arg Leu Pro 
145                 150                 155                 160 


Arg Ala Ile Ala Pro Gly Leu Ala Met Asp Met Ala Leu Thr Gly Glu 
                165                 170                 175     


Pro Ile Asp Ala Gln Arg Ala Phe Ser Ile Gly Leu Val Asn Arg Val 
            180                 185                 190         


Val Pro Ala Gly Thr Ala Leu Ala Ala Ala Cys Glu Leu Gly Glu Arg 
        195                 200                 205             


Ile Ala Gly His Ala Asp His Ala Val Leu Ala Thr Lys Ala Leu Leu 
    210                 215                 220                 


Ala Arg Gly Arg Asp Gly Glu Leu Ala Asp Glu Tyr Lys Ala His Arg 
225                 230                 235                 240 


Glu Leu Leu Ser Glu Ile Ile Asp Ser Pro Gly Ala Arg Ala Gly Ala 
                245                 250                 255     


Arg Asp Phe Val Gln Gly Arg Ser Gly Gly Thr Gly 
            260                 265             


<210>  320
<211>  648
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  320
atgcaagcgt taggtgtcct cgtcgtggac cgccatcccg tcatcaggta cgcgctgtcg       60

tccctgctgg acacaagagt ggcgtggacc gccgaagcgg ccacgagcga cgaggcatgg      120

aacgccgtca ggcagtgctg gccgggtgtc gtcgtactcg agctggagct ggagggcacg      180

accagcggtg ccgatctgtg tcagcgggtg aaggcgatgg agaacgcgcc ccgggtcgtg      240

gtcttcaccg gagacgcctc gcccggcgcc gtcgtcaccg ccatctcggc cggagccgac      300

agcttcctgc acaagagcgt cggcagcgcg gaactggccg acgccgtggt gcgcacccac      360

ctcggccagc gcatgtggat actcggcaag agcgaacgcg accacataga cgtgcggagc      420

gtcacgcccg acgggctgcc cgccatcacc cgccgggaag aacaggtgct gagcctcgtg      480

ctgcgccggt acaccaacga ggaaatcgcc ggtgaactct ccctggcccc gcagaccata      540

aagaaccagg tcagcagcgc cctgcggaag ctgggcgtca gcggacgccg cgagctgttc      600

cgcaagtact cctcccaggc cggggtgacc accggagcca ggggctga                   648


<210>  321
<211>  215
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  321

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Val Ile Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Val Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Met Glu Asn Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Ala Ser Pro Gly Ala Val Val Thr Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Asp Ala Val Val Arg Thr His Leu Gly Gln Arg Met Trp Ile Leu 
        115                 120                 125             


Gly Lys Ser Glu Arg Asp His Ile Asp Val Arg Ser Val Thr Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Gly Glu Leu Ser Leu Ala 
                165                 170                 175     


Pro Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Gln Ala Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  322
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamR1 polypeptide

<400>  322

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Val Leu Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Ile Ala Trp Thr Ala Asp 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Ile Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Thr Ser Gly Ala 
    50                  55                  60                  


Glu Leu Cys Gln Arg Val Lys Ala Met Glu Asn Gly Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Ala Ser Pro Gly Ala Val Leu Thr Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Asp Ala Val Val Arg Thr His Leu Gly Gln Arg Met Trp Ile Leu 
        115                 120                 125             


Ala Lys Ser Glu Arg Asp His Ile Asp Val Arg Ser Val Thr Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Asn Val Leu Ser Ile Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Gly Glu Leu Ser Leu Ala 
                165                 170                 175     


Pro Gln Thr Ile Arg Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Gln Ala Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  323
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamR1 polypeptide

<400>  323

Met Gln Ala Ile Gly Val Leu Val Val Asp Arg His Pro Leu Ile Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Ile Leu Glu Thr Arg Val Ala Trp Thr Gly Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Val Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Met Glu Asn Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Ala Ser Pro Gly Ala Val Val Thr Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Asp Ala Val Val Arg Thr His Leu Gly Gln Arg Met Trp Ile Leu 
        115                 120                 125             


Gly Lys Ser Glu Arg Asp His Ile Asp Val Lys Ser Val Thr Pro Asp 
    130                 135                 140                 


Gly Val Pro Ala Ile Thr Lys Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Phe Thr Asn Glu Glu Ile Ala Gly Glu Leu Ser Leu Ala 
                165                 170                 175     


Pro Gln Thr Ile Lys Asn Gln Val Thr Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Phe Ser Ser Gln Ala Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  324
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamR1 polypeptide

<400>  324

Met Gln Ala Leu Gly Val Leu Val Val Asp Arg His Pro Val Ile Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Leu Leu Asp Thr Arg Met Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Gly Thr Ser Asp Glu Ala Trp Asn Ala Val Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Ser Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Val Glu Asn Ala Pro Lys Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Ala Ser Pro Ala Ala Val Ile Thr Ala Leu Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Glu Ala Val Val Lys Thr His Leu Gly Gln Arg Val Trp Ile Ile 
        115                 120                 125             


Ala Lys Thr Glu Arg Asp His Ile Asp Val Arg Ser Val Thr Pro Asp 
    130                 135                 140                 


Gly Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Lys Arg Tyr Thr Asn Glu Glu Ile Ala Gly Glu Leu Ser Leu Ala 
                165                 170                 175     


Pro Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Lys Lys Tyr Ser Ser Gln Ala Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  325
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamR1 polypeptide

<400>  325

Met Gln Ala Ile Gly Val Leu Val Val Asp Arg His Pro Leu Ile Arg 
1               5                   10                  15      


Tyr Ala Leu Ser Ser Val Leu Glu Thr Arg Met Ala Trp Thr Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Glu Glu Ala Phe Asn Ala Val Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Thr Ser Gly Ala 
    50                  55                  60                  


Glu Leu Cys Gln Arg Val Lys Ala Met Glu Gln Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Gly Asp Ala Thr Pro Gly Ala Val Leu Thr Ala Ile Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Met Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Asp Ala Val Val Arg Thr His Leu Gly Gln Arg Val Trp Ile Leu 
        115                 120                 125             


Gly Lys Thr Glu Arg Asp His Val Asp Val Arg Ser Ile Ser Pro Asp 
    130                 135                 140                 


Gly Leu Pro Gly Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Tyr Thr Asn Glu Glu Ile Ala Gly Asp Leu Ser Val Ala 
                165                 170                 175     


Pro Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Gly 
            180                 185                 190         


Val Ser Gly Arg Arg Glu Leu Phe Arg Lys Phe Ser Ser Gln Gly Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  326
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamR1 polypeptide

<400>  326

Met Gln Ala Val Gly Val Leu Val Val Asp Arg His Pro Leu Ile Arg 
1               5                   10                  15      


Tyr Gly Leu Ser Ser Leu Leu Glu Thr Arg Val Ala Trp Ser Ala Glu 
            20                  25                  30          


Ala Ala Thr Ser Asp Glu Ala Trp Asn Ala Leu Arg Gln Cys Trp Pro 
        35                  40                  45              


Gly Val Val Val Leu Glu Leu Glu Leu Glu Gly Thr Thr Ser Gly Ala 
    50                  55                  60                  


Asp Leu Cys Gln Arg Val Lys Ala Met Glu Asn Ala Pro Arg Val Val 
65                  70                  75                  80  


Val Phe Thr Ala Asp Gly Ser Pro Gly Gly Val Ile Thr Ala Leu Ser 
                85                  90                  95      


Ala Gly Ala Asp Ser Phe Leu His Lys Ser Val Gly Ser Ala Glu Leu 
            100                 105                 110         


Ala Glu Ala Val Val Arg Thr His Leu Gly Gln Arg Val Trp Ile Leu 
        115                 120                 125             


Gly Lys Ser Glu Arg Asp His Ile Glu Leu Arg Thr Val Thr Pro Glu 
    130                 135                 140                 


Ala Leu Pro Ala Ile Thr Arg Arg Glu Glu Gln Val Leu Ser Leu Val 
145                 150                 155                 160 


Leu Arg Arg Phe Thr Asn Glu Glu Ile Ala Gly Glu Leu Ser Ile Ala 
                165                 170                 175     


Pro Gln Thr Ile Lys Asn Gln Val Ser Ser Ala Leu Arg Lys Leu Ala 
            180                 185                 190         


Leu Ser Gly Arg Arg Glu Leu Phe Arg Lys Tyr Ser Ser Gln Ala Gly 
        195                 200                 205             


Val Thr Thr Gly Ala Arg Gly 
    210                 215 


<210>  327
<211>  984
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  327
gtgaccgcat ccgctgaacc ggccgccgcc gggcaccgcg tgatcgacgt gtgcgcgctg       60

gccctggacc gggagtgctg gcgcacgtac ttccgcgggc tcggcgccgt ggcgccgacg      120

tatctgcgcg ccttcggccg ccacgccacg gcggtcttcg gcgccgacta cgcccgcttc      180

cgtgcccgcc tgggcgcggg ggaccaggac ggcgccgtcg acctgctcgt cgcgggacaa      240

ccggaacgcg tggacaccga ggcgctgctg cggaccatgg acgacaacgg cgtcgtccac      300

caggtcctga tgagctgcgg cggtgtcaca gccgacgggg acgacgtcaa cagccgggtc      360

gccgccgtcg ccgccaaggc gcccgaccgg ctccaggcat gggcgggcat cgacctcacc      420

gaccccgggc gggccgtcgc ggaactggaa cgctgccaca ccctcggcat gcggggcttc      480

gcggtgaccc ccttctggca gggagtcgac ccgcgcgacg cggcccacga cccggtcttc      540

gccagggcgc aggagctcgg catgccgctg tggctgcaca ccgggcacca tttctcgcgg      600

cacgccgccg agttgtgcca cccccgcaac gtcgactgga tcgccctgcg ccaccccggc      660

ctgccgatcg tcgcggggca cgccgcctgg ccctgggtgc tcgagctggt ctccgtcgcc      720

caacgccacc gccacgtcca cctcgacatc tcctcccacc ggccgcagtg gatgtcccgc      780

cccggatcgg gctgggagcc actgctcctg tacggcagca ccgtgctgcg cgaccggatc      840

ctgttcggct cggcgacctg ggtcaacgcc gaccccgtcg ccgtgcttgc cggacaggtg      900

gccgccctcg gcctcggcga cgaggtcacg gacggctggc tgtacggcaa cgcggcccgg      960

cttctcgggc tcggacccgg ctga                                             984


<210>  328
<211>  327
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  328

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Arg Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Thr Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Ala Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Gly Ala Gly Asp Gln Asp Gly Ala Val Asp Leu Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Arg Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Val Leu Met Ser Cys Gly Gly Val Thr Ala Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Thr Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Ala Ala His 
                165                 170                 175     


Asp Pro Val Phe Ala Arg Ala Gln Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Val Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Trp Pro Trp Val Leu Glu Leu Val Ser Val Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val His Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Ser Arg Pro Gly Ser Gly Trp Glu Pro Leu Leu Leu Tyr Gly 
            260                 265                 270         


Ser Thr Val Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Val Leu Ala Gly Gln Val Ala Ala Leu Gly 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  329
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamH polypeptide

<400>  329

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Arg Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Val Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Thr Tyr Val Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Glu Tyr Ala Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Gly Ala Gly Asp Gln Asp Gly Ala Val Asp Leu Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Arg Thr Met Asp Glu Asn 
                85                  90                  95      


Gly Val Val His Gln Val Leu Met Ser Cys Gly Ala Val Thr Ala Asp 
            100                 105                 110         


Ala Glu Asp Val Asn Ser Arg Val Ala Ala Val Ala Gly Arg Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Thr Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Ala Ala His 
                165                 170                 175     


Asp Pro Val Phe Ala Arg Ala Gln Glu Leu Gly Leu Pro Leu Trp Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Val Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Tyr Pro Tyr Val Leu Glu Leu Val Thr Val Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val His Val Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Val Ser Arg Pro Gly Ser Gly Trp Glu Pro Leu Leu Leu Tyr Gly 
            260                 265                 270         


Ser Thr Val Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Val Val Ala Gly Gln Val Ala Ala Ile Gly 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  330
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamH polypeptide

<400>  330

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Lys Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Gly Ala Val Ala Pro Thr Tyr Leu Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Ile Phe Gly Ala Asp Tyr Ala Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Gly Ala Gly Asp Gln Asp Gly Ala Ile Asp Leu Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Lys Thr Met Asp Glu Asn 
                85                  90                  95      


Gly Val Val His Gln Val Leu Val Ser Cys Ala Gly Met Thr Ala Asp 
            100                 105                 110         


Ala Asp Asp Val Asn Ser Arg Met Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Lys 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Thr Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Ala Ala His 
                165                 170                 175     


Asp Pro Val Phe Ala Arg Ala Gln Glu Leu Gly Met Pro Leu Trp Leu 
            180                 185                 190         


His Ser Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Leu Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Trp Pro Trp Val Leu Glu Leu Val Ser Val Ala 
225                 230                 235                 240 


Asn Arg His Arg His Ile His Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Ser Arg Pro Gly Ser Gly Trp Glu Pro Leu Leu Leu Tyr Gly 
            260                 265                 270         


Ser Thr Val Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Val Leu Ala Gly Gln Val Ala Ala Leu Ala 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Glu Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  331
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamH polypeptide

<400>  331

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Arg Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Ala Ala Ile Gly Pro Thr Tyr Val Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Gly Val Phe Ala Ala Asp Tyr Ala Arg Phe Arg Ala Arg Val 
    50                  55                  60                  


Gly Ala Ala Asp Gln Asp Gly Ala Val Asp Leu Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Arg Thr Met Asp Glu Gln 
                85                  90                  95      


Gly Val Val His Gln Val Leu Met Ser Cys Gly Gly Val Thr Ala Asp 
            100                 105                 110         


Gly Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Ile Ala Glu Leu Glu Arg Cys His Ser Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Val Gln Gly Val Asp Pro Arg Asp Ala Ala His 
                165                 170                 175     


Asp Pro Val Phe Ala Arg Ala Gln Glu Leu Gly Met Pro Leu Phe Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Gly Ala Asp Met Cys His Pro 
        195                 200                 205             


Arg Asn Ile Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Trp Pro Phe Val Leu Glu Leu Val Ser Val Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val His Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Ser Arg Pro Gly Ser Gly Trp Glu Pro Leu Leu Leu Tyr Gly 
            260                 265                 270         


Ser Thr Leu Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Glu Pro Val Ala Val Leu Ala Gly Gln Val Ala Gly Leu Gly 
    290                 295                 300                 


Leu Gly Asp Glu Leu Thr Asp Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  332
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamH polypeptide

<400>  332

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Lys Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Leu Asp Arg Glu Cys Trp Arg Thr Tyr Phe Arg 
            20                  25                  30          


Gly Leu Ala Ala Val Ala Pro Thr Tyr Leu Lys Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Met Phe Gly Ala Asp Tyr Ala Arg Phe Arg Ala Arg Leu 
    50                  55                  60                  


Gly Ala Gly Asp Gln Asp Ala Ala Met Asp Leu Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Arg Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Leu His Gln Val Leu Met Ser Cys Gly Ala Leu Thr Ala Asp 
            100                 105                 110         


Ala Asp Asp Val Asn Ser Arg Val Ala Ala Val Ala Ala Lys Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Ile Ala Glu Leu Glu Arg Cys His Thr Leu Gly Met Arg Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Leu Glu Pro Arg Asp Ala Ala His 
                165                 170                 175     


Asp Pro Val Phe Ala Arg Ala Gln Glu Leu Gly Leu Pro Leu Phe Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Lys His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Leu Asp Trp Ile Ala Leu Arg His Pro Gly Leu Pro Ile Val 
    210                 215                 220                 


Ala Gly His Ala Ala Trp Pro Phe Ile Leu Glu Leu Leu Ser Val Ala 
225                 230                 235                 240 


Gln Lys His Arg His Val His Val Asp Ile Ser Ser His Arg Pro Asn 
                245                 250                 255     


Trp Ile Ser Arg Pro Gly Ser Gly Trp Asp Pro Met Leu Leu Trp Gly 
            260                 265                 270         


Ser Thr Leu Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Ile 
        275                 280                 285             


Gln Ala Asp Pro Val Ala Val Leu Ala Gly Gln Val Ala Gly Leu Gly 
    290                 295                 300                 


Leu Gly Glu Glu Leu Thr Asp Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  333
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamH polypeptide

<400>  333

Met Thr Ala Ser Ala Glu Pro Ala Ala Ala Gly His Arg Val Ile Asp 
1               5                   10                  15      


Val Cys Ala Leu Ala Ile Asp Arg Glu Cys Trp Arg Thr Phe Phe Arg 
            20                  25                  30          


Ala Leu Ala Ala Val Gly Pro Thr Tyr Val Arg Ala Phe Gly Arg His 
        35                  40                  45              


Ala Thr Ala Val Phe Gly Ala Asp Tyr Ala Arg Phe Arg Ala Arg Val 
    50                  55                  60                  


Gly Ala Gly Asp Gln Asp Ala Ala Leu Asp Met Leu Val Ala Gly Gln 
65                  70                  75                  80  


Pro Glu Arg Val Asp Thr Glu Ala Leu Leu Lys Thr Met Asp Asp Asn 
                85                  90                  95      


Gly Val Val His Gln Val Leu Val Ser Cys Gly Gly Leu Ser Gly Asp 
            100                 105                 110         


Gly Asp Asp Leu Asn Ser Arg Val Ala Ala Leu Ala Ala Arg Ala Pro 
        115                 120                 125             


Asp Arg Leu Gln Ala Trp Ala Gly Ile Asp Leu Thr Asp Pro Gly Arg 
    130                 135                 140                 


Ala Val Ala Glu Leu Glu Arg Cys His Thr Leu Gly Met Lys Gly Phe 
145                 150                 155                 160 


Ala Val Thr Pro Phe Trp Gln Gly Val Asp Pro Arg Asp Ala Ala His 
                165                 170                 175     


Glu Pro Val Phe Ala Arg Ala Asn Glu Leu Gly Met Pro Leu Phe Leu 
            180                 185                 190         


His Thr Gly His His Phe Ser Arg His Ala Ala Glu Leu Cys His Pro 
        195                 200                 205             


Arg Asn Val Asp Trp Ile Ala Leu Arg His Pro Ala Leu Pro Ile Val 
    210                 215                 220                 


Ala Ala His Ala Ala Phe Pro Phe Val Leu Asp Ile Val Ser Val Ala 
225                 230                 235                 240 


Gln Arg His Arg His Val His Leu Asp Ile Ser Ser His Arg Pro Gln 
                245                 250                 255     


Trp Met Thr Arg Pro Gly Ser Gly Phe Glu Pro Leu Val Leu Tyr Gly 
            260                 265                 270         


Ser Thr Val Leu Arg Asp Arg Ile Leu Phe Gly Ser Ala Thr Trp Val 
        275                 280                 285             


Asn Ala Asp Pro Val Ala Val Met Ala Ala Gln Val Ala Ala Leu Gly 
    290                 295                 300                 


Leu Gly Asp Glu Val Thr Asp Gly Trp Leu Tyr Gly Asn Ala Ala Arg 
305                 310                 315                 320 


Leu Leu Gly Leu Gly Pro Gly 
                325         


<210>  334
<211>  681
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  334
ttgcgcgaga tgaagcagcg gccggcgaag cagccgctca gtcgtgagca gatcgtgcag       60

gcggcggtgc ggctcctcga cgagggaggc gtgcgcaacc tgcgcatgcg gcagctcgcc      120

gactcactga gttcggcgcc gatgtcgctc tactggcatg tgccgaccaa ggacgatctg      180

ctggaactgg ccatcgacgc cgtcttcccc gacccgccga gcccgtccgg ttcgggggac      240

tggcgcgccg acatcaagac gggcgcgacc gacctgttcg aggtgctgct gcggcactcg      300

tggatgatcg agctgatggg cggccatccc ccggtggggc cccgggccct cgcgcacacc      360

agcgccatca tccagatcct ggagcaggcc cgcttctccc ccgcccagtt ggactccgcg      420

ctctcggcga tctactacta caccgtcggc gcggccctgt ccgaggcgtc ctggcaggcc      480

atggcccggc agagcgccga gagcgaggag gagtgggcga accgtctcgg gccctacctc      540

ggctcggcca cgcaggatca tccggcgtcc ctcgccgact acgtcaaacg cagcgcctcc      600

agcagcacgg gccagcggtt ccacgacggc ctggagtgca tggtttccgg catggagcag      660

atgcgttcac tgaacacgtg a                                                681


<210>  335
<211>  226
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  335

Met Arg Glu Met Lys Gln Arg Pro Ala Lys Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Val Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Glu Leu Ala 
    50                  55                  60                  


Ile Asp Ala Val Phe Pro Asp Pro Pro Ser Pro Ser Gly Ser Gly Asp 
65                  70                  75                  80  


Trp Arg Ala Asp Ile Lys Thr Gly Ala Thr Asp Leu Phe Glu Val Leu 
                85                  90                  95      


Leu Arg His Ser Trp Met Ile Glu Leu Met Gly Gly His Pro Pro Val 
            100                 105                 110         


Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Ile Gln Ile Leu Glu 
        115                 120                 125             


Gln Ala Arg Phe Ser Pro Ala Gln Leu Asp Ser Ala Leu Ser Ala Ile 
    130                 135                 140                 


Tyr Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Met Ala Arg Gln Ser Ala Glu Ser Glu Glu Glu Trp Ala Asn Arg Leu 
                165                 170                 175     


Gly Pro Tyr Leu Gly Ser Ala Thr Gln Asp His Pro Ala Ser Leu Ala 
            180                 185                 190         


Asp Tyr Val Lys Arg Ser Ala Ser Ser Ser Thr Gly Gln Arg Phe His 
        195                 200                 205             


Asp Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Met Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  336
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamR2 polypeptide

<400>  336

Met Arg Glu Met Lys Gln Arg Pro Gly Lys Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Val Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Glu Leu Ala 
    50                  55                  60                  


Leu Asp Ala Val Phe Pro Asp Pro Pro Ser Pro Ser Gly Ser Gly Asp 
65                  70                  75                  80  


Trp Arg Ala Asp Ile Lys Thr Gly Ala Thr Asp Leu Phe Glu Leu Leu 
                85                  90                  95      


Leu Arg His Ser Trp Leu Leu Glu Leu Met Gly Gly His Pro Pro Val 
            100                 105                 110         


Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Leu Gln Ile Leu Glu 
        115                 120                 125             


Gln Ala Arg Phe Ser Pro Ala Gln Leu Asp Thr Ala Val Ser Ala Ile 
    130                 135                 140                 


Tyr Tyr Phe Thr Val Gly Ala Ala Leu Thr Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Met Ala Arg Gln Ser Ala Glu Ser Glu Glu Glu Trp Ala Asn Arg Ile 
                165                 170                 175     


Gly Pro Tyr Leu Gly Ser Ala Thr Gln Asp His Pro Ala Ser Leu Ala 
            180                 185                 190         


Asp Tyr Val Lys Arg Ser Ala Ser Ser Thr Thr Gly Gln Arg Phe His 
        195                 200                 205             


Asp Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Met Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  337
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamR2 polypeptide

<400>  337

Met Arg Glu Met Lys Gln Arg Pro Ala Lys Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Val Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Glu Leu Ala 
    50                  55                  60                  


Met Asp Ala Val Phe Pro Asp Pro Pro Ser Pro Ser Gly Ser Gly Asp 
65                  70                  75                  80  


Trp Arg Ala Asp Ile Arg Thr Gly Ala Thr Asp Leu Phe Glu Val Val 
                85                  90                  95      


Leu Arg His Ser Trp Val Ile Glu Leu Met Gly Gly His Pro Pro Val 
            100                 105                 110         


Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Leu Gln Leu Leu Glu 
        115                 120                 125             


Gln Ala Arg Phe Ser Pro Ala Gln Leu Asp Ser Ala Leu Thr Ala Ile 
    130                 135                 140                 


Tyr Tyr Tyr Thr Leu Gly Ala Ala Val Ser Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Met Ala Arg Gln Ser Ala Glu Ser Glu Glu Asp Trp Ala Asn Arg Leu 
                165                 170                 175     


Gly Pro Tyr Leu Gly Ser Ala Thr Gln Asp His Pro Ala Ser Leu Ala 
            180                 185                 190         


Asp Tyr Val Lys Arg Ser Ala Ser Ser Ser Ser Gly Gln Arg Phe His 
        195                 200                 205             


Asp Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Leu Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  338
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamR2 polypeptide

<400>  338

Met Arg Glu Met Lys Gln Arg Pro Ala Lys Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Leu Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Asn Leu Ala Asp Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Glu Leu Ala 
    50                  55                  60                  


Ile Asp Ala Val Phe Pro Glu Pro Pro Ser Pro Ser Gly Ser Gly Asp 
65                  70                  75                  80  


Trp Lys Ala Asp Ile Lys Thr Gly Ala Thr Asp Leu Trp Glu Leu Leu 
                85                  90                  95      


Val Arg His Ser Tyr Met Ile Glu Leu Leu Gly Gly His Pro Pro Val 
            100                 105                 110         


Gly Pro Arg Ala Leu Ala His Thr Ser Ala Ile Ile Gln Ile Leu Glu 
        115                 120                 125             


Gln Gly Arg Phe Ser Pro Ala Gln Leu Asp Ser Ala Leu Ser Ala Ile 
    130                 135                 140                 


Trp Tyr Phe Thr Val Gly Ala Ala Leu Ser Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Met Ala Arg Gln Thr Ala Glu Ser Glu Glu Glu Trp Ala Asn Arg Val 
                165                 170                 175     


Gly Pro Tyr Leu Ala Ser Ala Thr Gln Asp His Pro Ala Ser Leu Ala 
            180                 185                 190         


Asp Phe Val Lys Arg Ser Ala Ser Ser Ser Thr Gly Gln Arg Phe His 
        195                 200                 205             


Asp Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Met Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  339
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamR2 polypeptide

<400>  339

Met Arg Glu Met Lys Gln Arg Pro Ala Lys Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Val Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Gln Leu Ala Glu Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Glu Leu Ala 
    50                  55                  60                  


Ile Asp Ala Val Tyr Pro Asp Pro Pro Ser Pro Ser Gly Ser Gly Asp 
65                  70                  75                  80  


Trp Arg Ala Asp Ile Lys Thr Gly Ala Thr Asp Leu Phe Asp Val Leu 
                85                  90                  95      


Leu Arg His Ser Trp Leu Ile Glu Leu Leu Ala Ala His Pro Pro Leu 
            100                 105                 110         


Gly Pro Arg Ala Leu Gly His Thr Ser Ala Met Leu Gln Ile Leu Glu 
        115                 120                 125             


Gln Ala Arg Phe Ser Pro Gly Gln Val Asp Ser Ala Leu Thr Ala Ile 
    130                 135                 140                 


Trp Tyr Tyr Thr Ile Gly Ala Ala Met Ser Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Leu Ala Arg Gln Ser Ala Glu Ser Asp Glu Glu Trp Ala Asn Arg Val 
                165                 170                 175     


Ala Pro Tyr Leu Gly Ser Ala Thr Gln Asp His Pro Ala Ser Leu Ala 
            180                 185                 190         


Asp Tyr Val Arg Arg Ser Ala Ser Ser Ser Thr Gly Gln Arg Phe His 
        195                 200                 205             


Glu Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Met Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  340
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamR2 polypeptide

<400>  340

Met Arg Glu Met Lys Asn Arg Pro Ala Arg Gln Pro Leu Ser Arg Glu 
1               5                   10                  15      


Gln Ile Val Gln Ala Ala Val Arg Leu Leu Asp Glu Gly Gly Ile Arg 
            20                  25                  30          


Asn Leu Arg Met Arg Gln Leu Ala Asp Ser Leu Ser Ser Ala Pro Met 
        35                  40                  45              


Ser Leu Tyr Trp His Val Pro Thr Lys Asp Asp Leu Leu Asp Leu Ala 
    50                  55                  60                  


Leu Asp Ala Ile Phe Pro Asp Pro Pro Ser Pro Ser Gly Ser Ala Asp 
65                  70                  75                  80  


Trp Arg Ala Asp Ile Lys Thr Gly Ala Thr Asp Leu Phe Glu Val Leu 
                85                  90                  95      


Ile Arg His Ser Trp Val Ile Glu Leu Val Gly Ala His Pro Pro Leu 
            100                 105                 110         


Gly Pro Arg Gly Leu Ala His Thr Ser Gly Ile Leu Gln Ile Leu Glu 
        115                 120                 125             


Gln Ala Arg Phe Ser Pro Gly Gln Met Asp Ser Ala Leu Ser Ala Ile 
    130                 135                 140                 


Tyr Tyr Tyr Thr Val Gly Ala Ala Leu Ser Glu Ala Ser Trp Gln Ala 
145                 150                 155                 160 


Met Ala Arg Gln Thr Ala Glu Ser Glu Glu Glu Trp Ala Asn Arg Val 
                165                 170                 175     


Ala Pro Tyr Leu Ala Thr Ala Thr Gln Asp His Pro Gly Ser Leu Ala 
            180                 185                 190         


Asp Tyr Val Lys Arg Ser Ala Ser Ser Ser Thr Gly Gln Arg Phe His 
        195                 200                 205             


Asp Gly Leu Glu Cys Met Val Ser Gly Met Glu Gln Met Arg Ser Leu 
    210                 215                 220                 


Asn Thr 
225     


<210>  341
<211>  1581
<212>  DNA
<213>  Streptomyces aurantiacus

<400>  341
gtgctcgcgg tcctctcgct gagccttctg gtcgtcgccc ttgatctgac ggtgctgaac       60

gtggccctgc ccacgctcag caccgaactc gagccgtcgt cggtgcagtt gctgtggatc      120

gtcgacgtct actcgctcgt cgtggccggg ctgctcatca gttgcggcac gctcggcgac      180

cgcctgggcc gcaagcgatt cctgtgcctg ggcttcctcg tcttcggcgc cgcctcggcc      240

accgcggcct gggcgaacgg gcccgcgatg ctgatcgcgg cccgcgcgct gctcggcatc      300

ggcgccgcga tcatcatgcc gtcgacgctg tcgatcatcc gtaacgtctt cacggaccgc      360

aaggaacgca cggtggcgct cgccgtgtgg gccaccatgt ccgcggccgg tgccgcggtc      420

ggccccgtgg tgggcggtgt catgatcgag cacttctggt ggggctcggt cttcctgatc      480

aatgtgccga tcatggtctt cgcgctgatc gccgcgctgg ccctggtgcc ggagtcccgg      540

catcccaacc cgccgcgctg ggacaccgtc ggcgcggcgc tgtccgtcac cggcctgatc      600

tccctcgtgt acgccatcca gcacggcggc gcggaggggc tcgaggccca gacgatcatc      660

acgggtgtcc tggggatcgt gctgctcacc gccctggtgc tgcgggtgct gcgggtgccc      720

gccccgctct tcgacccggc gctgttccgc aaccgcgcgt tctccgtggc ggtcgtgacc      780

gtggtcctcg ccatgttcgg catgggcggg ctgatgctgc tgctcactca gcactggcag      840

ttcatcggcg gcgcctcgcc gatggagtcg ggtctgcggc tgctgccgct gctcctggcc      900

accatgatcg gtgctccggc catgtccgtg atcgtcccga agtacgggac gcggtacgcg      960

atgatgatcg ggatgggtct gatcggaggg gcgttcttcg tcctgatgaa cgtcgagccc     1020

gacaccgagt actgggtctt cgcgatcgca ctcgcgggca tcggcgcggg agcgggctgc     1080

gccatgacgg ccgcgtcgga cgccatcatg tcgacggccg aggcggacac cgcgggcggc     1140

gccgcgggca tcgaggagac ctcctacgaa ctcggcaacg gactgagcgt ggcgatcatg     1200

ggcagcgtgg cgtccgcgct gttccgcagg gagatggaca cctccgtgcc cggagtggac     1260

gccaagtcca tggacgcggc acgggagggc ctccccgacg ccgtcggggt cgccgcggcg     1320

ctgccgggct ccgccggggc ggagttgaag cggcgggccg acgcggcgtt cgcggacgcg     1380

ttcgggttca cgtcgctgtg caccggcatc attctcgtcc tggtcgcgat cgccgtgttc     1440

ttgttcatcc cgcgttcggc ggggcgggtc accgcggggg ccgaggacgg cggtggcgga     1500

cccgaagggg gcgtggacct ggtcaagcag gcgccggggg aggacgccga gaaccgggcc     1560

gagcccgtgg accggccctg a                                               1581


<210>  342
<211>  526
<212>  PRT
<213>  Streptomyces aurantiacus

<400>  342

Met Leu Ala Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
1               5                   10                  15      


Thr Val Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Val Gln Leu Leu Trp Ile Val Asp Val Tyr Ser Leu Val Val 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
    50                  55                  60                  


Lys Arg Phe Leu Cys Leu Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Trp Ala Asn Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
            100                 105                 110         


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Leu Ala 
        115                 120                 125             


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
    130                 135                 140                 


Gly Gly Val Met Ile Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Asn Val Pro Ile Met Val Phe Ala Leu Ile Ala Ala Leu Ala Leu Val 
                165                 170                 175     


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Val Gly Ala 
            180                 185                 190         


Ala Leu Ser Val Thr Gly Leu Ile Ser Leu Val Tyr Ala Ile Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Leu Glu Ala Gln Thr Ile Ile Thr Gly Val Leu 
    210                 215                 220                 


Gly Ile Val Leu Leu Thr Ala Leu Val Leu Arg Val Leu Arg Val Pro 
225                 230                 235                 240 


Ala Pro Leu Phe Asp Pro Ala Leu Phe Arg Asn Arg Ala Phe Ser Val 
                245                 250                 255     


Ala Val Val Thr Val Val Leu Ala Met Phe Gly Met Gly Gly Leu Met 
            260                 265                 270         


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Met 
        275                 280                 285             


Glu Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Met Ser Val Ile Val Pro Lys Tyr Gly Thr Arg Tyr Ala 
305                 310                 315                 320 


Met Met Ile Gly Met Gly Leu Ile Gly Gly Ala Phe Phe Val Leu Met 
                325                 330                 335     


Asn Val Glu Pro Asp Thr Glu Tyr Trp Val Phe Ala Ile Ala Leu Ala 
            340                 345                 350         


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
        355                 360                 365             


Ile Met Ser Thr Ala Glu Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
    370                 375                 380                 


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Met Asp Thr Ser Val 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Glu Gly Leu Pro 
            420                 425                 430         


Asp Ala Val Gly Val Ala Ala Ala Leu Pro Gly Ser Ala Gly Ala Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Ala Phe Ala Asp Ala Phe Gly Phe Thr 
    450                 455                 460                 


Ser Leu Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Ala Val Phe 
465                 470                 475                 480 


Leu Phe Ile Pro Arg Ser Ala Gly Arg Val Thr Ala Gly Ala Glu Asp 
                485                 490                 495     


Gly Gly Gly Gly Pro Glu Gly Gly Val Asp Leu Val Lys Gln Ala Pro 
            500                 505                 510         


Gly Glu Asp Ala Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  343
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of pamW polypeptide

<400>  343

Met Leu Ala Val Leu Ser Leu Ser Leu Leu Val Val Gly Leu Asp Leu 
1               5                   10                  15      


Thr Val Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Leu Gln Leu Leu Trp Ile Val Asp Val Tyr Ser Leu Val Val 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Ser Leu Gly Asp Arg Ile Gly Arg 
    50                  55                  60                  


Lys Arg Phe Leu Cys Leu Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Tyr Ala Asn Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
            100                 105                 110         


Ile Arg Asn Leu Phe Thr Asp Arg Lys Asp Arg Thr Val Ala Leu Ala 
        115                 120                 125             


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
    130                 135                 140                 


Gly Gly Val Met Leu Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Asn Val Pro Ile Met Val Phe Ala Leu Ile Ala Ala Leu Ala Val Val 
                165                 170                 175     


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Val Gly Ala 
            180                 185                 190         


Ala Leu Ser Val Thr Gly Leu Val Ser Ile Val Tyr Ala Ile Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Leu Glu Ala Gln Thr Leu Val Thr Gly Val Leu 
    210                 215                 220                 


Gly Ile Val Leu Leu Thr Ala Leu Val Leu Arg Val Leu Arg Val Pro 
225                 230                 235                 240 


Ala Pro Val Phe Asp Pro Ala Leu Phe Arg Asn Arg Ala Phe Ser Val 
                245                 250                 255     


Ala Ile Val Thr Val Val Leu Gly Met Tyr Gly Met Gly Gly Leu Met 
            260                 265                 270         


Leu Leu Leu Thr Gln His Trp Gln Phe Val Gly Gly Ala Ser Pro Met 
        275                 280                 285             


Glu Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Met Ser Val Ile Val Pro Lys Tyr Gly Thr Lys Tyr Gly 
305                 310                 315                 320 


Met Met Ile Gly Met Gly Leu Ile Gly Gly Ala Phe Phe Val Leu Met 
                325                 330                 335     


Asn Val Glu Pro Asp Thr Asp Tyr Trp Val Phe Ala Ile Ala Leu Ala 
            340                 345                 350         


Gly Ile Gly Ala Gly Ala Gly Cys Ala Leu Thr Ala Ala Ser Asp Ala 
        355                 360                 365             


Ile Met Ser Thr Ala Glu Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
    370                 375                 380                 


Asp Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Gly Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Leu Asp Thr Ser Val 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Glu Gly Leu Pro 
            420                 425                 430         


Asp Ala Val Gly Val Ala Ala Ala Leu Pro Gly Ser Ala Gly Ala Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Ala Phe Ala Asp Ala Trp Gly Phe Thr 
    450                 455                 460                 


Ser Leu Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Ala Val Phe 
465                 470                 475                 480 


Leu Phe Ile Pro Arg Ser Ala Gly Arg Val Thr Ala Gly Ala Asp Asp 
                485                 490                 495     


Gly Gly Gly Gly Pro Glu Gly Gly Val Asp Leu Val Lys Gln Ala Pro 
            500                 505                 510         


Gly Glu Asp Ala Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  344
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of pamW polypeptide

<400>  344

Met Leu Ala Val Leu Thr Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
1               5                   10                  15      


Ser Ile Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Val Gln Val Leu Trp Ile Val Asp Val Phe Ser Leu Val Val 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Met Gly Arg 
    50                  55                  60                  


Lys Arg Phe Leu Cys Leu Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Trp Ala Asn Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Val Gly Ile Gly Gly Ala Ile Ile Ile Pro Ser Thr Leu Ser Ile 
            100                 105                 110         


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Leu Ala 
        115                 120                 125             


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
    130                 135                 140                 


Gly Gly Leu Met Leu Glu His Phe Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Asn Val Pro Ile Met Val Phe Ala Leu Ile Ala Ala Leu Ala Leu Val 
                165                 170                 175     


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Trp Asp Thr Val Gly Ala 
            180                 185                 190         


Ala Leu Thr Val Thr Ala Leu Ile Ser Leu Val Tyr Ala Ile Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Leu Glu Ala Gln Thr Ile Ile Thr Gly Val Leu 
    210                 215                 220                 


Gly Ile Val Leu Leu Thr Ala Leu Val Leu Arg Val Leu Lys Val Pro 
225                 230                 235                 240 


Ala Pro Leu Phe Asp Pro Gly Leu Phe Arg Asn Arg Ala Phe Ser Val 
                245                 250                 255     


Ala Val Val Thr Val Val Leu Ala Met Phe Gly Met Gly Gly Val Met 
            260                 265                 270         


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Val 
        275                 280                 285             


Glu Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Met Ser Val Ile Val Pro Lys Tyr Gly Thr Lys Phe Ala 
305                 310                 315                 320 


Met Val Ile Gly Met Gly Leu Ile Gly Gly Ala Phe Phe Val Leu Ile 
                325                 330                 335     


Asn Val Glu Pro Asp Thr Glu Tyr Phe Val Phe Ala Ile Ala Leu Ala 
            340                 345                 350         


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
        355                 360                 365             


Ile Met Ser Ser Ala Glu Ala Asp Thr Ala Gly Gly Ala Ala Gly Ile 
    370                 375                 380                 


Glu Glu Ser Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Ile Asp Thr Ser Val 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Glu Gly Leu Pro 
            420                 425                 430         


Asp Ala Val Gly Leu Ala Ala Ala Leu Pro Gly Ser Ala Gly Ala Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Ala Phe Ala Asp Ala Phe Gly Phe Thr 
    450                 455                 460                 


Ser Leu Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Ala Val Phe 
465                 470                 475                 480 


Leu Phe Ile Pro Arg Ser Ala Gly Arg Val Thr Ala Ala Ala Glu Asp 
                485                 490                 495     


Gly Gly Gly Gly Pro Glu Gly Gly Val Asp Leu Val Lys Gln Ala Pro 
            500                 505                 510         


Gly Glu Asp Ala Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  345
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of pamW polypeptide

<400>  345

Met Leu Ala Leu Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Ile 
1               5                   10                  15      


Thr Val Leu Asn Leu Ala Leu Pro Thr Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Val Gln Val Leu Trp Ile Val Asp Val Tyr Ser Leu Val Val 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
    50                  55                  60                  


Lys Lys Phe Leu Cys Leu Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Phe Ala Asn Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Leu Gly Ile Gly Ala Ala Ile Ile Met Pro Ser Thr Leu Ser Ile 
            100                 105                 110         


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Leu Ala 
        115                 120                 125             


Leu Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Leu Val 
    130                 135                 140                 


Gly Gly Val Met Ile Asp His Phe Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Asn Val Pro Ile Met Val Phe Ala Leu Ile Ala Ala Ile Ala Met Val 
                165                 170                 175     


Pro Glu Ser Arg His Pro Asn Pro Pro Lys Trp Asp Thr Val Gly Ala 
            180                 185                 190         


Ala Leu Ser Val Thr Gly Leu Ile Thr Leu Val Phe Ala Ile Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Leu Glu Ala Gln Thr Leu Ile Thr Gly Val Leu 
    210                 215                 220                 


Gly Ile Val Leu Leu Thr Ala Leu Val Leu Arg Val Leu Arg Val Pro 
225                 230                 235                 240 


Ala Pro Leu Phe Asp Pro Ala Leu Phe Arg Asn Arg Ala Phe Ser Val 
                245                 250                 255     


Ala Val Val Thr Val Val Leu Ala Met Phe Gly Met Ala Gly Leu Met 
            260                 265                 270         


Leu Leu Leu Thr Gln His Trp Gln Phe Ile Gly Gly Ala Ser Pro Met 
        275                 280                 285             


Glu Thr Gly Met Arg Leu Leu Pro Leu Leu Leu Ala Ser Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Ile Ser Val Ile Ile Pro Lys Tyr Gly Thr Lys Tyr Ala 
305                 310                 315                 320 


Met Leu Ile Gly Met Gly Leu Ile Gly Gly Ala Phe Phe Val Leu Met 
                325                 330                 335     


Asn Ile Asp Pro Asp Thr Glu Tyr Trp Val Phe Ala Ile Ala Val Ala 
            340                 345                 350         


Gly Ile Gly Ala Gly Ala Gly Cys Gly Met Thr Ala Ala Ser Asp Ala 
        355                 360                 365             


Ile Met Ser Thr Ala Glu Ala Glu Thr Ala Gly Gly Ala Ala Gly Ile 
    370                 375                 380                 


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Thr Ala Leu Phe Arg Arg Glu Met Asp Thr Ser Val 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Glu Gly Leu Pro 
            420                 425                 430         


Glu Ala Leu Gly Val Ala Ala Ala Leu Pro Gly Ser Ala Gly Ala Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Ala Phe Ala Asp Ala Phe Gly Phe Thr 
    450                 455                 460                 


Ser Ile Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Gly Val Phe 
465                 470                 475                 480 


Leu Phe Val Pro Arg Thr Ala Gly Arg Val Thr Ala Ala Ala Glu Asp 
                485                 490                 495     


Gly Gly Gly Gly Pro Glu Gly Gly Val Asp Leu Val Lys Gln Ala Pro 
            500                 505                 510         


Gly Asp Asp Ala Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  346
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of pamW polypeptide

<400>  346

Met Leu Ala Ile Leu Ser Leu Ser Leu Leu Val Met Ala Leu Asp Leu 
1               5                   10                  15      


Thr Val Leu Asn Val Ala Leu Pro Thr Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Val Gln Leu Leu Trp Ile Val Asp Val Phe Ser Leu Val Val 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
    50                  55                  60                  


Lys Arg Trp Leu Cys Leu Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Trp Ala Gln Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Leu Gly Ile Gly Ala Ala Met Ile Leu Pro Ser Thr Leu Ser Ile 
            100                 105                 110         


Ile Arg Asn Val Phe Thr Asp Arg Arg Glu Arg Thr Val Ala Met Ala 
        115                 120                 125             


Leu Phe Ala Ser Leu Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
    130                 135                 140                 


Gly Gly Val Met Ile Glu His Tyr Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Asn Val Pro Ile Met Val Phe Ala Leu Ile Ala Ala Ile Ala Leu Val 
                165                 170                 175     


Pro Glu Ser Arg His Pro Asn Pro Pro Arg Phe Asp Thr Val Gly Gly 
            180                 185                 190         


Ala Leu Ser Val Thr Gly Leu Val Ser Leu Val Tyr Ala Leu Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Ile Glu Ala Gln Thr Ile Ile Thr Gly Val Leu 
    210                 215                 220                 


Gly Ile Val Ile Leu Thr Ala Leu Ile Ile Lys Val Leu Arg Val Pro 
225                 230                 235                 240 


Ala Pro Leu Phe Glu Pro Ala Met Phe Lys Asn Arg Ala Phe Ser Leu 
                245                 250                 255     


Ala Val Val Thr Leu Val Ile Ala Met Phe Gly Met Gly Gly Leu Met 
            260                 265                 270         


Leu Leu Leu Thr Gln His Trp Gln Phe Val Gly Gly Ala Ser Pro Leu 
        275                 280                 285             


Glu Ser Gly Leu Arg Leu Leu Pro Met Leu Leu Ala Thr Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Met Ser Val Ile Val Pro Lys Tyr Gly Thr Lys Tyr Ala 
305                 310                 315                 320 


Met Ile Ile Gly Met Gly Leu Ile Gly Gly Ala Phe Phe Val Leu Met 
                325                 330                 335     


Asn Leu Glu Pro Asp Thr Glu Tyr Tyr Val Phe Ala Ile Ala Val Ala 
            340                 345                 350         


Gly Ile Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Asp Ala 
        355                 360                 365             


Ile Met Ser Thr Ala Glu Ala Glu Ser Ala Gly Gly Ala Ala Gly Ile 
    370                 375                 380                 


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Ser Ala Leu Phe Arg Arg Glu Val Asp Thr Ser Leu 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Asp Gly Leu Pro 
            420                 425                 430         


Asp Ala Leu Gly Val Ala Ala Gly Leu Pro Gly Ser Ala Gly Gly Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Ala Phe Ala Asp Ala Phe Gly Phe Thr 
    450                 455                 460                 


Ser Leu Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Ala Val Phe 
465                 470                 475                 480 


Leu Phe Ile Pro Arg Thr Ala Gly Lys Val Thr Ala Gly Ala Glu Asp 
                485                 490                 495     


Gly Gly Ala Gly Pro Glu Gly Gly Val Asp Leu Leu Lys Gln Gly Pro 
            500                 505                 510         


Ala Glu Asp Gly Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  347
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of pamW polypeptide

<400>  347

Met Leu Ala Val Leu Ser Leu Ser Leu Leu Val Val Ala Leu Asp Leu 
1               5                   10                  15      


Thr Val Ile Asn Leu Ala Leu Pro Ser Leu Ser Thr Glu Leu Glu Pro 
            20                  25                  30          


Ser Ser Val Gln Leu Leu Trp Ile Val Asp Val Tyr Thr Leu Val Ile 
        35                  40                  45              


Ala Gly Leu Leu Ile Ser Cys Gly Thr Leu Gly Asp Arg Leu Gly Arg 
    50                  55                  60                  


Lys Arg Phe Leu Cys Met Gly Phe Leu Val Phe Gly Ala Ala Ser Ala 
65                  70                  75                  80  


Thr Ala Ala Trp Ala Asn Gly Pro Ala Met Leu Ile Ala Ala Arg Ala 
                85                  90                  95      


Leu Leu Gly Ile Gly Ala Ala Val Ile Met Pro Thr Ser Met Thr Ile 
            100                 105                 110         


Ile Arg Asn Val Phe Thr Asp Arg Lys Glu Arg Thr Val Ala Ile Ala 
        115                 120                 125             


Val Trp Ala Thr Met Ser Ala Ala Gly Ala Ala Val Gly Pro Val Val 
    130                 135                 140                 


Gly Gly Val Met Ile Glu His Trp Trp Trp Gly Ser Val Phe Leu Ile 
145                 150                 155                 160 


Gln Val Pro Ile Met Val Phe Ala Leu Ile Gly Ala Leu Ala Leu Val 
                165                 170                 175     


Pro Glu Thr Arg His Pro Asn Pro Pro Arg Tyr Glu Thr Val Gly Ala 
            180                 185                 190         


Ala Leu Ser Val Thr Gly Ile Leu Ser Leu Val Tyr Ala Ile Gln His 
        195                 200                 205             


Gly Gly Ala Glu Gly Val Glu Ala Gln Thr Ile Val Thr Gly Val Leu 
    210                 215                 220                 


Gly Leu Val Leu Leu Thr Ala Leu Leu Leu Arg Val Leu Arg Ile Pro 
225                 230                 235                 240 


Ala Pro Leu Phe Asp Pro Ala Leu Phe Arg Asn Lys Ala Phe Ser Val 
                245                 250                 255     


Ala Val Val Thr Leu Val Leu Ala Met Phe Gly Met Gly Gly Val Val 
            260                 265                 270         


Met Leu Leu Thr Gln His Trp Gln Phe Val Gly Gly Ala Ser Pro Met 
        275                 280                 285             


Glu Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Ala Thr Met Ile Gly 
    290                 295                 300                 


Ala Pro Ala Met Ser Val Ile Val Pro Lys Tyr Gly Thr Lys Tyr Ala 
305                 310                 315                 320 


Met Leu Ile Gly Met Gly Leu Ile Gly Gly Ala Tyr Phe Val Leu Met 
                325                 330                 335     


Asn Leu Glu Pro Glu Thr Glu Tyr Phe Met Phe Ala Ile Ala Leu Ala 
            340                 345                 350         


Gly Val Gly Ala Gly Ala Gly Cys Ala Met Thr Ala Ala Ser Glu Ala 
        355                 360                 365             


Val Met Ser Thr Ala Glu Ala Asp Thr Ala Gly Gly Ala Gly Gly Ile 
    370                 375                 380                 


Glu Glu Thr Ser Tyr Glu Leu Gly Asn Gly Leu Ser Val Ala Ile Met 
385                 390                 395                 400 


Gly Ser Val Ala Ser Ala Leu Phe Arg Lys Glu Met Glu Thr Ser Ile 
                405                 410                 415     


Pro Gly Val Asp Ala Lys Ser Met Asp Ala Ala Arg Glu Gly Leu Pro 
            420                 425                 430         


Asp Ala Val Gly Met Ala Ala Ala Leu Pro Gly Ser Ala Gly Ala Glu 
        435                 440                 445             


Leu Lys Arg Arg Ala Asp Ala Gly Trp Ala Asp Ala Phe Gly Phe Thr 
    450                 455                 460                 


Ser Leu Cys Thr Gly Ile Ile Leu Val Leu Val Ala Ile Ala Val Phe 
465                 470                 475                 480 


Leu Tyr Ile Pro Arg Ser Ala Ala Arg Leu Thr Ala Gly Ala Glu Asp 
                485                 490                 495     


Gly Gly Gly Ala Pro Glu Gly Gly Ile Asp Leu Val Lys Gln Ala Pro 
            500                 505                 510         


Gly Glu Asp Ala Glu Asn Arg Ala Glu Pro Val Asp Arg Pro 
        515                 520                 525     


<210>  348
<211>  1743
<212>  DNA
<213>  Streptomyces fulvissimus

<400>  348
atgaccacag cccccgaacg ccccgccgcc accactccct atctggcgag cggccccgac       60

gacctggtgc gccgcttcgt ccgcgagggc gaccacgtgc acgcggcggc aacgatgtca      120

cggcccaacg ccctgctgaa cgcggtgtgc cgggccttcg ccgggagcca cagcctgacg      180

gtgagcacca cggccgtgca ctccagcgcc cacgcgctcg ccctctccgg tgccgtacgc      240

aaggtgatca cgggcttcgt cggtgacacc ttcccctcgc cgcgccccaa ccgcctctac      300

cgcgaactcg ccgagggcag gcccttcgag atcgagatgt ggtcgctgct cagctacacc      360

cagcggctga tggccgccgc gctcggccag cccttcgcca ccaccggttc gatgctcgcc      420

gagaccgatc tccggcacgg caaggagggc agcctccacc tggtgcccca ccccgaggac      480

ccggagcggt ccgtcaccct cctcaccccg ctgcgcccgc gcatcgccct cttccacggg      540

gtcgtcgccg accggcgcgg caacgtggtc gccgtcccgc cgctgggcga gggcgcctgg      600

gccgcgtacg ccgccaccga cggggtcctg gcctccgtcg aggcgatcgt cgacgacgag      660

gtgatcgcgg ccatgcctga ccgggtggtg atccccgccg cccgcgtgct cggcctgtgc      720

gaggcgccgc tcggcgccca cccgcagtcg ctgcgtacgg gtggactggc cggtgtcgag      780

ggctacttgg acgactacgc gttcctcacc gacatcgtga ccgcctgcaa ggccccggag      840

acggccgccg cctggtacga ggagtgggtc ggcggggtgg agagccacgc cgactacctg      900

gagcggctgg gcgaggagcg ccgcgcctcg ctggccttcc ccgctccccc agccgctccc      960

cggcccccgg cggacgggtc cggcgcgccc accgagcagg agcagctcat cgtgctcggc     1020

gcccgcgcgg tggccgagct ggtccgggag cgcggctacg acacgctgct cgccgggatc     1080

ggcacctcgc acatgtccgc gtggctggcg gcccggctgc tggcggccga cggtgtgcag     1140

gtgcaggtgg ccgccgagct gggcctgcag tcgatggacc ccgaggcggg cgacgtcttc     1200

ctcttcagcc agcggcacgc cgagcgctcg cagatgctgg cgggggtcgc ggagacgctg     1260

ggcggcgcgg tcgccgccaa cccgcgctgc ctgggcgtgc tttcggcggc ggagatcgac     1320

ccggacgcca acatcaacac gacgctgctg cccgacggcc gctggatcac cggatcgggc     1380

ggggccaacg acatcgcctc gtccgtggac tgcgtggtcg tcgcggtcgc ctcgccccgc     1440

cgctacgtac cgcggctgac ccacctcacc agtccgggcc tgcacgtccg tgacgtggtc     1500

agccagttcg gccgcttcac ccggccgggg gacggcaccg ccttcgagct gacgagctgg     1560

ctgccgccgg tgccgggccg gggccgcggc gcgcaggacc tccccgacgg gccggaggca     1620

gccgtacgcg aactcaccgg ctggaccgtg ggcgtcagcc ggttcctgac cgacgagaag     1680

gccgtcacca ccgaagaact cacgctcctg cgcaccatgg acccggaagg cttctaccga     1740

tga                                                                   1743


<210>  349
<211>  580
<212>  PRT
<213>  Streptomyces fulvissimus

<400>  349

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Ser Gly Pro Asp Asp Leu Val Arg Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Gly Ser His Ser Leu Thr Val Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Ile Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Ser Leu His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Leu Leu Thr Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn Val Val Ala Val 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Glu Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Ile 
            260                 265                 270         


Val Thr Ala Cys Lys Ala Pro Glu Thr Ala Ala Ala Trp Tyr Glu Glu 
        275                 280                 285             


Trp Val Gly Gly Val Glu Ser His Ala Asp Tyr Leu Glu Arg Leu Gly 
    290                 295                 300                 


Glu Glu Arg Arg Ala Ser Leu Ala Phe Pro Ala Pro Pro Ala Ala Pro 
305                 310                 315                 320 


Arg Pro Pro Ala Asp Gly Ser Gly Ala Pro Thr Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Arg Ala Val Ala Glu Leu Val Arg Glu Arg Gly 
            340                 345                 350         


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala Trp 
        355                 360                 365             


Leu Ala Ala Arg Leu Leu Ala Ala Asp Gly Val Gln Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Leu Gly Leu Gln Ser Met Asp Pro Glu Ala Gly Asp Val Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Ala Gly Val 
                405                 410                 415     


Ala Glu Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu Gly 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Leu Leu Pro Asp Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Val Ala Val Ala Ser Pro Arg 
465                 470                 475                 480 


Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Thr Arg Pro Gly Asp Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg Glu 
    530                 535                 540                 


Leu Thr Gly Trp Thr Val Gly Val Ser Arg Phe Leu Thr Asp Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Glu Glu Leu Thr Leu Leu Arg Thr Met Asp Pro Glu 
                565                 570                 575     


Gly Phe Tyr Arg 
            580 


<210>  350
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of nonT polypeptide

<400>  350

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Ser Gly Pro Asp Asp Leu Val Lys Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Gly Ser His Ser Leu Thr Ile Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Lys 
65                  70                  75                  80  


Lys Leu Ile Thr Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Ile Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Thr Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Ser Val His Val Val Pro His Pro Glu Glu 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Leu Leu Thr Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn Val Val Ala Val 
            180                 185                 190         


Pro Pro Ile Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Leu Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Ser Met Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Glu Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Ile 
            260                 265                 270         


Val Thr Ala Cys Lys Ala Pro Glu Thr Gly Ala Ala Phe Tyr Glu Glu 
        275                 280                 285             


Tyr Val Ala Gly Val Glu Ser His Gly Asp Tyr Leu Glu Arg Ile Ala 
    290                 295                 300                 


Glu Glu Arg Arg Ala Ser Leu Ala Phe Pro Ala Pro Pro Ala Gly Pro 
305                 310                 315                 320 


Arg Pro Pro Ala Asp Gly Ser Gly Ala Pro Thr Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Arg Ala Val Ala Asp Leu Val Arg Glu Arg Gly 
            340                 345                 350         


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala Trp 
        355                 360                 365             


Leu Ala Ala Arg Leu Val Ala Ala Asp Gly Val Gln Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Leu Gly Leu Gln Ser Met Asp Pro Glu Gly Gly Asp Met Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Ala Gly Val 
                405                 410                 415     


Ala Asp Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu Gly 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Leu Leu Pro Asp Gly Lys Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Leu Ala Val Ala Ser Pro Arg 
465                 470                 475                 480 


Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Val His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Thr Arg Pro Gly Asp Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg Glu 
    530                 535                 540                 


Leu Thr Gly Trp Thr Val Gly Val Ser Arg Phe Leu Thr Asp Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Glu Glu Leu Thr Leu Leu Arg Thr Met Asp Pro Glu 
                565                 570                 575     


Gly Phe Tyr Arg 
            580 


<210>  351
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of nonT polypeptide

<400>  351

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Ser Gly Pro Asp Asp Leu Val Arg Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Ala Ser His Ser Leu Thr Val Ser Ser Ser 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Glu Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Ile Glu 
            100                 105                 110         


Leu Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Ser Leu His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Met Leu Thr Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Leu Ala Asp Arg Arg Gly Asn Val Val Ala Val 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Glu Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Leu Pro Asp Arg Val Ile Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Glu Gly Tyr Leu Asp Asp Tyr Gly Tyr Ile Thr Asp Ile 
            260                 265                 270         


Val Thr Ala Cys Lys Ala Pro Glu Thr Ala Ala Ala Trp Tyr Glu Glu 
        275                 280                 285             


Tyr Val Gly Gly Val Glu Ser His Ala Glu Tyr Leu Glu Arg Leu Gly 
    290                 295                 300                 


Glu Glu Arg Arg Gly Ser Ile Ala Phe Pro Ala Pro Pro Ala Ala Pro 
305                 310                 315                 320 


Arg Pro Pro Ala Asp Gly Ser Gly Ala Pro Thr Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Arg Ala Val Ala Glu Met Val Arg Glu Arg Gly 
            340                 345                 350         


Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala Trp 
        355                 360                 365             


Leu Ala Ala Arg Leu Ile Ala Ala Asp Gly Val Gln Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Leu Gly Leu Gln Ser Met Asp Pro Glu Ala Gly Asp Val Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Ile Ala Gly Val 
                405                 410                 415     


Ala Asp Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu Gly 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Met Ile Pro Asp Gly Lys Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Val Ala Val Ala Ser Pro Arg 
465                 470                 475                 480 


Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Thr Arg Pro Gly Asp Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Lys Glu 
    530                 535                 540                 


Leu Thr Gly Trp Thr Val Gly Val Ser Arg Phe Leu Thr Glu Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Glu Glu Leu Thr Val Leu Arg Thr Met Asp Pro Glu 
                565                 570                 575     


Gly Phe Tyr Arg 
            580 


<210>  352
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of nonT polypeptide

<400>  352

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Glu Asp Leu Val Arg Arg Tyr Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Ser Met Ser Arg Pro Asn Ala Leu Ile Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Gly Ser His Ser Leu Thr Val Ser Thr Thr 
    50                  55                  60                  


Ala Val His Thr Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Glu Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Lys Val Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Ile Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Ser Leu His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Leu Leu Thr Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn Val Val Ala Val 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Thr Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Glu Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Ser Glu Ile 
            260                 265                 270         


Leu Thr Ala Cys Arg Ala Pro Glu Ser Ala Ala Ala Phe Tyr Glu Asp 
        275                 280                 285             


Trp Val Gly Ala Val Glu Ser His Ala Glu Tyr Leu Glu Arg Val Gly 
    290                 295                 300                 


Glu Glu Arg Arg Ala Ser Leu Ala Phe Pro Ala Pro Pro Gly Ala Pro 
305                 310                 315                 320 


Arg Pro Pro Ala Asp Gly Ser Gly Ala Pro Ser Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Arg Ala Val Ala Glu Leu Val Arg Asp Arg Gly 
            340                 345                 350         


Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr Ser His Val Ser Ala Trp 
        355                 360                 365             


Val Ala Ala Arg Leu Leu Ala Ala Glu Gly Val Asn Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Leu Gly Leu Gln Ser Leu Asp Pro Glu Ala Gly Asp Val Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Ile Ala Gly Met 
                405                 410                 415     


Ala Asp Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Val Gly 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Met Ile Pro Asp Gly Lys Trp Leu Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Val Ala Val Ala Ser Pro Arg 
465                 470                 475                 480 


Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Thr Arg Pro Gly Asp Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg Glu 
    530                 535                 540                 


Leu Thr Gly Trp Thr Val Gly Val Ser Arg Phe Leu Thr Asp Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Glu Glu Leu Thr Val Leu Arg Thr Val Asp Pro Glu 
                565                 570                 575     


Gly Phe Tyr Lys 
            580 


<210>  353
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of nonT polypeptide

<400>  353

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Glu Asp Leu Val Arg Arg Phe Val Lys Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Gly Ser His Ser Leu Thr Leu Ser Ser Thr 
    50                  55                  60                  


Ala Val His Ser Ser Gly His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Leu Ile Ser Gly Phe Val Gly Asp Ser Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Leu Phe Ser Leu Leu Ser Tyr Ser Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Arg Asp Gly Ser Val His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Leu Leu Thr Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn Val Leu Ala Leu 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Tyr Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Gly Pro Leu Gly Ala His Pro Gln Thr Met Arg Thr Gly Gly Leu 
                245                 250                 255     


Gly Gly Val Glu Gly Tyr Val Asp Asp Tyr Ala Phe Val Thr Asp Ile 
            260                 265                 270         


Leu Thr Ala Cys Arg Ala Pro Glu Ser Ala Ala Ala Trp Phe Asp Glu 
        275                 280                 285             


Phe Val Gly Ala Val Glu Ser His Ala Glu Phe Leu Glu Arg Ile Ala 
    290                 295                 300                 


Glu Glu Arg Arg Ala Ser Leu Ala Phe Pro Ala Pro Pro Ala Ala Pro 
305                 310                 315                 320 


Lys Pro Pro Ala Asp Gly Ser Gly Ala Pro Thr Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Arg Ala Val Ala Asp Leu Val Arg Glu Arg Gly 
            340                 345                 350         


Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr Ser His Leu Ser Ala Trp 
        355                 360                 365             


Leu Ala Ala Arg Leu Leu Ala Ala Asp Gly Val Gln Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Ile Gly Leu Gln Ser Met Asp Pro Glu Gly Gly Asp Ile Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Ile Ala Gly Val 
                405                 410                 415     


Ala Asp Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu Ala 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Glu Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Leu Leu Pro Asp Gly Arg Trp Val Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Val Gly Val Ala Ser Pro Lys 
465                 470                 475                 480 


Arg Tyr Val Pro Lys Leu Thr His Leu Thr Ser Pro Gly Leu His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ser Arg Pro Gly Asp Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Ile Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg Glu 
    530                 535                 540                 


Leu Thr Gly Trp Thr Val Gly Ile Ser Arg Phe Leu Thr Asp Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Glu Glu Leu Thr Leu Leu Arg Thr Leu Asp Pro Glu 
                565                 570                 575     


Gly Tyr Tyr Arg 
            580 


<210>  354
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of nonT polypeptide

<400>  354

Met Thr Thr Ala Pro Glu Arg Pro Ala Ala Thr Thr Pro Tyr Leu Ala 
1               5                   10                  15      


Ser Gly Pro Glu Asp Leu Val Arg Arg Tyr Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Ser Leu Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Ala Phe Ala Gly Ser His Ser Leu Thr Leu Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Gly His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Glu Ser Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Tyr Arg Glu Leu Ala Glu Ala Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Leu Trp Ser Leu Leu Ser Tyr Thr Gln Arg Ile Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Thr Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Ser Leu His Leu Ile Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Ser Val Thr Leu Leu Ser Pro Leu Arg Pro Arg Ile Ala 
                165                 170                 175     


Leu Phe His Gly Val Val Ala Asp Lys Arg Gly Asn Val Ile Ala Val 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Asp Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Glu Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Ile Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Ile Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Glu Gly Tyr Leu Asp Asp Tyr Ala Phe Val Thr Asp Ile 
            260                 265                 270         


Leu Thr Ala Cys Lys Ala Pro Glu Thr Ala Ala Ala Trp Tyr Asp Glu 
        275                 280                 285             


Tyr Val Gly Gly Val Glu Ser His Ala Glu Phe Leu Glu Lys Leu Gly 
    290                 295                 300                 


Glu Asp Arg Arg Ala Ser Ile Ala Phe Pro Ala Pro Pro Ala Ala Pro 
305                 310                 315                 320 


Arg Pro Pro Gly Asp Gly Ser Gly Ala Pro Ser Glu Gln Glu Gln Leu 
                325                 330                 335     


Ile Val Leu Gly Ala Lys Ala Val Ala Glu Leu Val Arg Glu Lys Gly 
            340                 345                 350         


Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala Trp 
        355                 360                 365             


Leu Ala Ala Arg Ile Leu Ala Ala Asp Gly Met Gln Val Gln Val Ala 
    370                 375                 380                 


Ala Glu Leu Gly Leu Gln Ser Val Asp Pro Glu Gly Gly Asp Val Phe 
385                 390                 395                 400 


Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Ala Gly Val 
                405                 410                 415     


Ala Asp Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu Ala 
            420                 425                 430         


Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr 
        435                 440                 445             


Met Val Pro Glu Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp 
    450                 455                 460                 


Ile Ala Ser Ser Val Asp Cys Val Val Val Gly Val Ala Thr Pro Arg 
465                 470                 475                 480 


Arg Tyr Val Pro Lys Leu Ser His Leu Thr Ser Pro Gly Leu His Val 
                485                 490                 495     


Arg Asp Val Val Ser Gln Phe Gly Arg Phe Thr Arg Pro Ala Glu Gly 
            500                 505                 510         


Thr Ala Phe Glu Leu Thr Ser Trp Ile Pro Pro Val Pro Gly Arg Gly 
        515                 520                 525             


Arg Gly Ala Gln Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg Asp 
    530                 535                 540                 


Leu Thr Gly Phe Thr Val Gly Val Ser Lys Phe Leu Thr Glu Glu Lys 
545                 550                 555                 560 


Ala Val Thr Thr Asp Glu Leu Thr Val Leu Arg Thr Ile Asp Pro Glu 
                565                 570                 575     


Gly Phe Tyr Arg 
            580 


<210>  355
<211>  1773
<212>  DNA
<213>  Streptomyces griseus

<400>  355
atgaccacag ccctcgaacg cccctccacc accggcccct acctggccac cggccccgac       60

gacctgatac gccgcttcgt ccgcgagggc gaccacgtgc acgccgcggc gacgatgtcg      120

cggcccaacg ccctgctgaa cgcggtgtgc cggaccttcg ccgggagcgg cagcatgacg      180

gtgagcacca ccgccgtgca ctccagcgcc catgcgctgg ccctctccgg cgccgtacgc      240

aaggtgatca ccgggttcgt cggcgacacc tacccctcac cgcgccccaa ccgcctctac      300

cgcgagctgg ccgagggccg gccgttcgag gtggagatgt ggtcgctgct gagctacacg      360

cagcggctga tggccgcggc gctcggccag cccttcgcca ccaccggctc gatgctcgcc      420

gagaccgacc tccggcacgg caaggagggc aagctccacc tggtgccgca ccccgaggac      480

ccggagcgca ccgtcaccct gctcagcccg ctgcgcccgc gcttcaccct cttccacggt      540

gtcgccgccg accgccgggg caacgtcgtg gcctgccccc cgctgggcga gggcgcctgg      600

gccgcgtacg ccgccaccga gggggtcctc gcctccgtgg aggcgatcgt cgacgacgag      660

gtgatcgccg cgatgccgga ccgggtggtg atccccgccg cccgcgtcct cggcctgtgc      720

gaggcgccgc tcggcgccca cccgcagtca ctgcgcacgg gtggactggc cggagtcgac      780

ggctacctgg acgactacga cttcctcacc gacatcgtgg ccgcctgcaa ggacccggag      840

tccgccgccg cctggtacga gaagtgggtc ggcggggcgg gcagccacgc cgactacctg      900

gagcggctgg gtgggacccg ccgcgccgcg ctggtgttcc ccgctccccc gggcgtcccg      960

gtcgccgtgg agaaggaccg gagcccggcg gacgggtccg ccgcccccac cgagcaggag     1020

cagctcatcg tgctcggcgc ccgcgcgatc gtcgacctgg tccgggagcg cggctacgac     1080

acgctgctcg ccgggatcgg cacctcgcac atgtccgcgt ggctggcggc ccggctgctg     1140

ggacgcgacg gcgtccaggt gcaggtggcc gccgagctgg gcctccagtc gatggacccc     1200

gaacccggcg acgtcttcct cttcagccaa cggcacgccg agcgctcgca gatgctggcg     1260

ggcgtcgcgg agacgctggg cggcgcggtc gccgccaacc cgcgctgcct gggcgtgctc     1320

tccgccgcgg agatcgaccc ggacgccaac atcaacacga cgctgctgcc cgacggccgt     1380

tggatcaccg gctccggcgg ggccaacgac atcgcctcgt ccgtggactg cgtcgtgatc     1440

gcggtcgcct cggcccgccg ctacgtaccc cggctgaccc acctcaccag tccgggcctg     1500

cgggtccgcg acgtggtcag ccagttcggg cgcttcaccc gcgccggggc cggcgacgcc     1560

ttcgagctgg cgagctggct gccgcccgtt ccgggccgcg gccgcgccgg gaaggacctc     1620

cccgacgggc cggaggcggc ggtgcgcgac ctcaccggct gggagttccc cgcggcctcc     1680

accggggtca gcggcttcct gaccgacgag aaggccgtca ccaccgaaga actcgtcctc     1740

ctgcgcacca tggacccgga aggtttctac cga                                  1773


<210>  356
<211>  591
<212>  PRT
<213>  Streptomyces griseus

<400>  356

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala 
        35                  40                  45              


Val Cys Arg Thr Phe Ala Gly Ser Gly Ser Met Thr Val Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Val Ala Cys 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Asp Phe Leu Thr Asp Ile 
            260                 265                 270         


Val Ala Ala Cys Lys Asp Pro Glu Ser Ala Ala Ala Trp Tyr Glu Lys 
        275                 280                 285             


Trp Val Gly Gly Ala Gly Ser His Ala Asp Tyr Leu Glu Arg Leu Gly 
    290                 295                 300                 


Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Asp Gly Ser Ala Ala Pro 
                325                 330                 335     


Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala Ile Val Asp 
            340                 345                 350         


Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Leu Gly Arg Asp Gly 
    370                 375                 380                 


Val Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln Ser Met Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg Trp Ile Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Ile 
465                 470                 475                 480 


Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr 
                485                 490                 495     


Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Thr Arg Ala Gly Ala Gly Asp Ala Phe Glu Leu Ala Ser Trp Leu Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Glu Phe Pro Ala Ala Ser 
545                 550                 555                 560 


Thr Gly Val Ser Gly Phe Leu Thr Asp Glu Lys Ala Val Thr Thr Glu 
                565                 570                 575     


Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly Phe Tyr Arg 
            580                 585                 590     


<210>  357
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of nonT polypeptide

<400>  357

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Lys Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Val Asn Ala 
        35                  40                  45              


Val Cys Arg Ser Phe Ala Gly Ser Gly Ser Met Thr Val Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Ile Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Lys Val His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Thr Ile Thr Leu Leu Ser Pro Leu Arg Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Val Ala Cys 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Met Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Met Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Ile Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Asp Phe Leu Thr Asp Ile 
            260                 265                 270         


Val Ala Ala Cys Lys Asp Pro Glu Ser Ala Ala Ala Trp Tyr Glu Lys 
        275                 280                 285             


Tyr Val Gly Gly Ala Gly Ser His Ala Asp Phe Leu Glu Arg Val Gly 
    290                 295                 300                 


Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Glu Gly Ser Ala Ala Pro 
                325                 330                 335     


Thr Glu Gln Asp Gln Leu Ile Val Leu Gly Ala Arg Ala Ile Val Glu 
            340                 345                 350         


Leu Val Arg Glu Arg Ala Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Leu Ser Ala Trp Ile Ala Ala Arg Leu Leu Gly Arg Asp Gly 
    370                 375                 380                 


Ile Asn Val Gln Val Ala Ala Glu Leu Gly Ile Gln Ser Met Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg Trp Ile Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Leu 
465                 470                 475                 480 


Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr 
                485                 490                 495     


Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Ser Arg Ala Gly Ala Gly Asp Ala Phe Glu Leu Ala Ser Trp Leu Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Arg Asp Leu Thr Gly Phe Glu Phe Pro Ala Ala Ser 
545                 550                 555                 560 


Thr Gly Val Ser Gly Phe Leu Thr Asp Glu Lys Ala Val Thr Thr Glu 
                565                 570                 575     


Glu Leu Val Leu Leu Arg Thr Met Asp Pro Asp Gly Phe Phe Arg 
            580                 585                 590     


<210>  358
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of nonT polypeptide

<400>  358

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Glu Asp Leu Ile Arg Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Val Asn Ala 
        35                  40                  45              


Val Cys Lys Thr Phe Ala Gly Ser Gly Ser Met Thr Val Ser Thr Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Gly Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Asp Ser Tyr Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Leu Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Lys Leu His Val Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Thr Leu Thr Leu Leu Ser Pro Leu Lys Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Val Ala Cys 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Glu Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Asp Phe Leu Thr Asp Met 
            260                 265                 270         


Val Ala Ala Cys Lys Asp Pro Asp Ser Ala Ala Ala Trp Tyr Glu Lys 
        275                 280                 285             


Phe Leu Gly Gly Ala Gly Ser His Ala Asp Tyr Met Glu Lys Val Gly 
    290                 295                 300                 


Gly Thr Arg Arg Ala Gly Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Asp Gly Ser Ala Ala Pro 
                325                 330                 335     


Thr Glu Gln Asp Gln Leu Ile Val Leu Gly Ala Arg Ala Ile Val Asp 
            340                 345                 350         


Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Met Ser Ala Trp Val Ala Ala Arg Ile Leu Gly Arg Glu Gly 
    370                 375                 380                 


Val Gln Val Gln Val Ala Ala Glu Leu Gly Val Gln Ser Met Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Val Phe Leu Tyr Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Ile Ala Gly Val Ala Asp Thr Leu Gly Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg Trp Ile Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Met 
465                 470                 475                 480 


Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu Ser His Leu Thr 
                485                 490                 495     


Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Thr Arg Ala Gly Ala Gly Asp Ala Phe Asp Leu Ala Ser Trp Leu Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Glu Phe Pro Ala Ala Ser 
545                 550                 555                 560 


Thr Gly Val Ser Gly Phe Leu Thr Glu Glu Lys Ala Val Thr Thr Glu 
                565                 570                 575     


Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly Phe Tyr Arg 
            580                 585                 590     


<210>  359
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of nonT polypeptide

<400>  359

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Arg Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Lys Pro Asn Ala Leu Val Asn Ala 
        35                  40                  45              


Val Cys Arg Thr Phe Ala Ala Ser Gly Ser Met Thr Leu Ser Ser Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Met Trp Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Glu Gly Lys Val His Val Val Pro His Pro Glu Glu 
145                 150                 155                 160 


Pro Glu Arg Thr Met Thr Leu Leu Thr Pro Leu Arg Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Ile Ala Cys 
            180                 185                 190         


Pro Pro Leu Gly Asp Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Gly 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Asn Ser Leu Arg Thr Ala Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Asp Phe Ile Thr Glu Ile 
            260                 265                 270         


Val Ala Ala Cys Lys Asp Pro Asp Thr Ala Ala Ala Phe Tyr Glu Arg 
        275                 280                 285             


Trp Val Gly Gly Ala Gly Ser His Ala Asp Tyr Leu Asp Lys Leu Gly 
    290                 295                 300                 


Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Asp Ala Ser Ala Ala Pro 
                325                 330                 335     


Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Lys Ala Ile Val Asp 
            340                 345                 350         


Leu Val Arg Glu Arg Gly Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Leu Gly Arg Glu Gly 
    370                 375                 380                 


Val Gln Val Gln Val Ala Ala Glu Leu Gly Ile Gln Ser Met Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Ile Ala Gly Val Ala Glu Ser Leu Gly Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Ile Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Leu Ile Pro Asp Gly Arg Trp Ile Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Ile 
465                 470                 475                 480 


Ala Val Ala Ser Gly Arg Arg Tyr Val Pro Lys Leu Thr His Leu Thr 
                485                 490                 495     


Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Thr Arg Ala Gly Ala Gly Asp Ala Phe Glu Leu Ala Ser Trp Leu Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Asp Phe Pro Gly Ala Ser 
545                 550                 555                 560 


Thr Gly Val Ser Ala Phe Leu Thr Glu Glu Lys Ala Val Thr Thr Asp 
                565                 570                 575     


Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly Phe Tyr Arg 
            580                 585                 590     


<210>  360
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of nonT polypeptide

<400>  360

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Glu Asp Leu Ile Lys Arg Phe Val Lys Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Val Ser Arg Pro Asn Ala Leu Ile Asn Ala 
        35                  40                  45              


Val Cys Arg Ser Phe Ala Ala Thr Gly Ser Met Thr Leu Ser Ser Thr 
    50                  55                  60                  


Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg 
65                  70                  75                  80  


Lys Met Ile Thr Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Arg Leu Phe Arg Asp Leu Ala Glu Gly Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Leu Trp Ser Leu Leu Ser Tyr Ser Gln Lys Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Asp Gly Lys Leu His Leu Val Pro His Pro Glu Asp 
145                 150                 155                 160 


Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Lys Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Val Ala Cys 
            180                 185                 190         


Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys 
225                 230                 235                 240 


Glu Gly Pro Leu Gly Ala His Pro Gln Thr Val Arg Thr Ala Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Asp Phe Leu Thr Glu Ile 
            260                 265                 270         


Val Gly Ala Cys Lys Glu Pro Glu Ser Ala Ala Ala Trp Tyr Asp Lys 
        275                 280                 285             


Phe Ile Gly Gly Ala Gly Thr His Ala Glu Tyr Leu Asp Arg Ile Gly 
    290                 295                 300                 


Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Asp Gly Ser Gly Ala Pro 
                325                 330                 335     


Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala Ile Val Asp 
            340                 345                 350         


Leu Val Arg Glu Arg Gly Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Leu Ser Ala Trp Val Ala Ala Arg Leu Leu Gly Arg Asp Gly 
    370                 375                 380                 


Ile Gln Val Gln Val Ala Ala Glu Leu Gly Ile Gln Ser Leu Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Asp Met Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Ile Ala Gly Val Ala Glu Thr Leu Ala Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Val Ala Leu Leu Ser Ala Ala Glu Ile Asp Pro Glu 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Val Leu Pro Asp Gly Arg Trp Val Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Met 
465                 470                 475                 480 


Ala Val Ala Ser Ala Lys Arg Tyr Val Pro Lys Leu Thr His Leu Thr 
                485                 490                 495     


Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Thr Arg Ala Gly Gly Gly Asp Ala Phe Glu Leu Ala Ser Trp Val Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Lys Asp Leu Thr Gly Trp Glu Phe Pro Ala Ala Ser 
545                 550                 555                 560 


Thr Ala Val Ser Gly Phe Leu Thr Glu Glu Lys Ala Val Thr Thr Glu 
                565                 570                 575     


Glu Leu Val Leu Leu Arg Thr Leu Asp Pro Glu Ala Phe Phe Arg 
            580                 585                 590     


<210>  361
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of nonT polypeptide

<400>  361

Met Thr Thr Ala Leu Glu Arg Pro Ser Thr Thr Gly Pro Tyr Leu Ala 
1               5                   10                  15      


Thr Gly Pro Asp Asp Leu Ile Arg Lys Tyr Val Lys Glu Gly Asp His 
            20                  25                  30          


Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Val Asn Ala 
        35                  40                  45              


Val Cys Lys Ser Phe Ala Gly Ser Gly Ser Met Thr Val Ser Thr Ser 
    50                  55                  60                  


Ala Val His Thr Ser Gly His Ala Leu Ala Leu Ser Gly Ala Val Lys 
65                  70                  75                  80  


Lys Val Ile Thr Gly Phe Ile Gly Glu Thr Tyr Pro Ser Pro Arg Pro 
                85                  90                  95      


Asn Lys Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro Phe Glu Val Glu 
            100                 105                 110         


Leu Trp Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu 
        115                 120                 125             


Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu 
    130                 135                 140                 


Arg His Gly Lys Asp Gly Lys Val His Leu Val Pro His Pro Glu Glu 
145                 150                 155                 160 


Pro Glu Arg Thr Leu Thr Leu Leu Ser Pro Leu Lys Pro Arg Phe Thr 
                165                 170                 175     


Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn Val Val Ala Cys 
            180                 185                 190         


Pro Pro Ile Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly 
        195                 200                 205             


Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala 
    210                 215                 220                 


Met Pro Glu Arg Val Val Ile Pro Ala Ala Arg Val Leu Ala Leu Cys 
225                 230                 235                 240 


Glu Ala Pro Leu Gly Ala His Pro Asn Thr Leu Arg Thr Gly Gly Leu 
                245                 250                 255     


Ala Gly Val Asp Ala Tyr Leu Asp Asp Tyr Asp Phe Leu Thr Asp Ile 
            260                 265                 270         


Val Gly Ala Cys Arg Asp Pro Glu Ser Ala Ala Ala Trp Tyr Asp Lys 
        275                 280                 285             


Trp Val Gly Gly Gly Gly Thr His Ala Glu Phe Leu Asp Arg Leu Gly 
    290                 295                 300                 


Ala Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Val Pro 
305                 310                 315                 320 


Val Ala Val Glu Lys Asp Arg Ser Pro Ala Glu Gly Ser Ala Ala Pro 
                325                 330                 335     


Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala Ile Val Asp 
            340                 345                 350         


Leu Val Arg Glu Arg Gly Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr 
        355                 360                 365             


Ser His Leu Ser Ala Trp Leu Ala Ala Arg Ile Leu Gly Lys Asp Gly 
    370                 375                 380                 


Ile Gln Val Gln Val Ala Ala Glu Leu Gly Ile Gln Ser Met Asp Pro 
385                 390                 395                 400 


Glu Pro Gly Glu Val Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser 
                405                 410                 415     


Gln Met Leu Ala Gly Val Ala Asp Thr Leu Ala Gly Ala Val Ala Ala 
            420                 425                 430         


Asn Pro Arg Cys Leu Ala Val Leu Ser Ala Ala Glu Ile Asp Pro Asp 
        435                 440                 445             


Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Lys Trp Ile Thr Gly 
    450                 455                 460                 


Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys Val Val Met 
465                 470                 475                 480 


Ala Val Ala Thr Ala Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr 
                485                 490                 495     


Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe 
            500                 505                 510         


Thr Arg Ala Gly Ala Gly Asp Ala Phe Glu Leu Ala Ser Trp Val Pro 
        515                 520                 525             


Pro Val Pro Gly Arg Gly Arg Ala Gly Lys Asp Leu Pro Asp Gly Pro 
    530                 535                 540                 


Glu Ala Ala Val Lys Asp Leu Thr Gly Trp Glu Phe Pro Ala Ala Ser 
545                 550                 555                 560 


Thr Ala Val Ser Gly Phe Leu Thr Asp Glu Lys Ala Val Thr Ser Glu 
                565                 570                 575     


Glu Leu Val Ile Leu Arg Ser Ile Asp Pro Asp Gly Phe Phe Arg 
            580                 585                 590     


<210>  362
<211>  1746
<212>  DNA
<213>  Streptomyces sp. SolWspMP

<400>  362
atgaccacag cccccgtacg cccctcagtc cctcatctgg ccgccggacc ggacgagttg       60

gtacgccgct tcgtccgcga gggcgaccat gtgcacgcgg cggccaccat gtcccggccc      120

aacgcgctgc tgaacgcggt gtgccgggcc ttcgccggca gccgcagcct caccgtgagc      180

accaccgccg tgcactccag cgcccacgcg ctcgccctct ccggggccgt acggaaggtg      240

atcaccggct tcgtcgggga caccttcccc tcgccgcgcc ccaaccgcct ctaccgggaa      300

ctcgccgacg ggaagccgtt cgagatcgag atgtggtcgc tgctcagcta cacgcagcgg      360

ctgatggcgg ccgccctcgg ccagcccttc gccaccaccg gctcgatgct cgcggagacc      420

gacctgcgcc acggcaagga gggcagcctc catctggtgg cccaccccga ggaccccgag      480

cggtcggtca ccctcctcgc cccgctgcgc ccgcgcttca ccctcttcca cggggtctgc      540

gccgaccggc gcggcaacgt ggtggccgtc ccgccgctgg gcgagggcgc ctgggccgcg      600

tacgcggcga cggagggcgt gctggcctcg gtggaggcga tcgtcgacga cgaggtgatc      660

gcggcgatgc cggaccgggt ggtcatcccc gccgcccggg tcctcggcct ctgcgaggcg      720

ccgctcggcg cccacccgca gtccctgcgt accggacagc tggccgggat cgacggctac      780

ctggacgact acgcgttcct caccgacatc gtgtccgcct gcaaggaccc gcagacggcc      840

gccgcctggt acgagcagtg ggtcggcggg gtggcaagcc acgccgagta cctggagcgg      900

ctgggcgagc agcggcgcgc cgcgctggtg ttccccgctc ccccgggccc gcccgcgcag      960

gccccggccc cggccgacgt ctccaccgcc cccaccgagc aggagcagct gatcgtgctc     1020

ggcgcgagga cggtcgcgga gctggtccgg gagcgcggct acgacacgct gctcgccggg     1080

atcggcacct cgcacatgtc ggcgtggctg gcggcccggc tgctggcccg cgacggcgtc     1140

caggtccggg tggccgccga gctggggctc cagtcgatgg atcccgaggc cggtgacgtc     1200

ttcctcttca gccagcggca cgccgagcgt tcgcagatgc tcaccggggt cgcggagacg     1260

ctgggcgggg cggtcgccgc caacccccgc tgcctggggg tgctgtcggc ggcggagatc     1320

gacccggacg ccaacatcaa caccacgctg ctgcccgacg gccgctggat caccggctcc     1380

ggaggcgcca acgacatcgc ctcctccgtg gactgcgtgg tgatcgcggt cgcctccccg     1440

cgccggtacg tgccccggct cacccatctg accagcccgg gcctccatgt ccgcgacgtg     1500

gtcagccagt tcgggcgctt cgcccgtacg ggtccgggca cgcccttcga gctgacgagc     1560

tggctcccgc cggtggcggg ccggggccgt accgcggagg acctccccga cgggccggag     1620

gccgccgtac gcgaactgac cggctgggac gtgggcgtcg gccggttcct gaccgacgag     1680

aaggccgtca ccaccgaaga actggcacta ctgcgcacca tggatccgga aggctgctac     1740

cgatga                                                                1746


<210>  363
<211>  581
<212>  PRT
<213>  Streptomyces sp. SolWspMP

<400>  363

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Arg Phe Val Arg Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala Val Cys 
        35                  40                  45              


Arg Ala Phe Ala Gly Ser Arg Ser Leu Thr Val Ser Thr Thr Ala Val 
    50                  55                  60                  


His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg Lys Val 
65                  70                  75                  80  


Ile Thr Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro Asn Arg 
                85                  90                  95      


Leu Tyr Arg Glu Leu Ala Asp Gly Lys Pro Phe Glu Ile Glu Met Trp 
            100                 105                 110         


Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Gly Ser Leu His Leu Val Ala His Pro Glu Asp Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Leu Leu Ala Pro Leu Arg Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Val Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala Met Pro 
    210                 215                 220                 


Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gln Leu Ala Gly 
                245                 250                 255     


Ile Asp Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Ile Val Ser 
            260                 265                 270         


Ala Cys Lys Asp Pro Gln Thr Ala Ala Ala Trp Tyr Glu Gln Trp Val 
        275                 280                 285             


Gly Gly Val Ala Ser His Ala Glu Tyr Leu Glu Arg Leu Gly Glu Gln 
    290                 295                 300                 


Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Asp Val Ser Thr Ala Pro Thr Glu Gln Glu Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Arg Thr Val Ala Glu Leu Val Arg Glu Arg 
            340                 345                 350         


Gly Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala 
        355                 360                 365             


Trp Leu Ala Ala Arg Leu Leu Ala Arg Asp Gly Val Gln Val Arg Val 
    370                 375                 380                 


Ala Ala Glu Leu Gly Leu Gln Ser Met Asp Pro Glu Ala Gly Asp Val 
385                 390                 395                 400 


Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Thr Gly 
                405                 410                 415     


Val Ala Glu Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu 
            420                 425                 430         


Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Leu Leu Pro Asp Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Ile Ala Val Ala Ser Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Gly Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Ala Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg 
    530                 535                 540                 


Glu Leu Thr Gly Trp Asp Val Gly Val Gly Arg Phe Leu Thr Asp Glu 
545                 550                 555                 560 


Lys Ala Val Thr Thr Glu Glu Leu Ala Leu Leu Arg Thr Met Asp Pro 
                565                 570                 575     


Glu Gly Cys Tyr Arg 
            580     


<210>  364
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant11 of nonT polypeptide

<400>  364

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Arg Phe Val Arg Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Thr Met Ser Arg Pro Asn Ala Leu Leu Asn Ala Val Cys 
        35                  40                  45              


Arg Ala Phe Ala Gly Ser Arg Ser Leu Thr Leu Ser Thr Thr Ala Val 
    50                  55                  60                  


His Thr Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg Lys Ile 
65                  70                  75                  80  


Ile Ser Gly Phe Ile Gly Glu Thr Phe Pro Ser Pro Arg Pro Asn Lys 
                85                  90                  95      


Val Tyr Arg Glu Leu Ala Asp Gly Lys Pro Phe Glu Ile Glu Met Phe 
            100                 105                 110         


Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met Ala Ala Ala Leu Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Gly Ser Leu His Leu Val Ala His Pro Glu Glu Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Leu Leu Ala Pro Leu Arg Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Val Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala Met Pro 
    210                 215                 220                 


Asp Arg Val Val Ile Pro Gly Ala Arg Val Leu Ala Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gln Ile Ala Gly 
                245                 250                 255     


Ile Asp Gly Tyr Leu Asp Asp Tyr Ala Phe Ile Thr Asp Ile Val Ser 
            260                 265                 270         


Ala Cys Lys Asp Pro Gln Thr Ala Ala Ala Tyr Tyr Glu Gln Phe Val 
        275                 280                 285             


Gly Gly Val Gly Ser His Ala Asp Tyr Leu Glu Arg Leu Gly Glu Gln 
    290                 295                 300                 


Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Gly Pro Ala Pro Ala Asp Val Ser Thr Ala Pro Thr Glu Gln Glu Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Arg Thr Val Ala Glu Leu Val Arg Glu Arg 
            340                 345                 350         


Gly Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Leu Ser Ala 
        355                 360                 365             


Trp Leu Ala Ala Arg Leu Leu Ala Arg Asp Gly Ile Gln Val Arg Leu 
    370                 375                 380                 


Ala Ala Glu Leu Gly Met Gln Ser Met Asp Pro Glu Ala Gly Glu Val 
385                 390                 395                 400 


Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Thr Gly 
                405                 410                 415     


Val Ala Glu Ser Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu 
            420                 425                 430         


Gly Val Leu Ser Ala Gly Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Leu Ile Pro Asp Gly Arg Trp Ile Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Ile Ala Val Ala Ser Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Gly Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Trp Ile Pro Pro Val Ala Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg 
    530                 535                 540                 


Glu Val Thr Gly Trp Asp Val Gly Val Gly Arg Phe Leu Thr Asp Glu 
545                 550                 555                 560 


Lys Ala Val Thr Ser Glu Glu Leu Ala Leu Leu Arg Thr Met Asp Pro 
                565                 570                 575     


Glu Gly Cys Tyr Arg 
            580     


<210>  365
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant12 of nonT polypeptide

<400>  365

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Arg Phe Val Arg Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Thr Leu Ser Arg Pro Asn Ala Leu Ile Asn Ala Val Cys 
        35                  40                  45              


Arg Ala Phe Ala Gly Ser Arg Ser Leu Thr Leu Ser Thr Thr Ala Val 
    50                  55                  60                  


His Ser Ser Gly His Ala Leu Ala Leu Ser Gly Ala Val Lys Lys Val 
65                  70                  75                  80  


Ile Thr Gly Phe Ile Gly Asp Thr Phe Pro Ser Pro Arg Pro Asn Arg 
                85                  90                  95      


Leu Phe Arg Glu Leu Ala Asp Gly Lys Pro Phe Glu Ile Glu Leu Trp 
            100                 105                 110         


Ser Leu Leu Ser Tyr Ser Gln Arg Leu Met Ala Ala Ala Leu Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Thr Met Leu Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Gly Ser Val His Leu Val Ala His Pro Glu Asp Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Leu Leu Ala Pro Leu Lys Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Leu Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Ala Ala Val Pro 
    210                 215                 220                 


Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Thr Leu Arg Thr Gly Gln Leu Ala Gly 
                245                 250                 255     


Ile Asp Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Ile Val Ser 
            260                 265                 270         


Ala Cys Lys Asp Pro Gln Thr Ala Ala Ala Trp Tyr Glu Gln Trp Ile 
        275                 280                 285             


Gly Gly Val Ala Ser His Ala Glu Tyr Val Glu Arg Leu Gly Glu Gln 
    290                 295                 300                 


Arg Arg Ala Ala Leu Val Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Asp Val Ser Thr Ala Pro Thr Glu Gln Asp Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Arg Thr Val Ala Asp Leu Val Arg Glu Lys 
            340                 345                 350         


Gly Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala 
        355                 360                 365             


Trp Leu Ala Ala Arg Leu Leu Ala Arg Asp Gly Ile Gln Val Arg Val 
    370                 375                 380                 


Ala Ala Glu Leu Gly Leu Gln Ser Leu Asp Pro Glu Ala Gly Asp Val 
385                 390                 395                 400 


Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Val Thr Gly 
                405                 410                 415     


Val Ala Glu Thr Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Ile 
            420                 425                 430         


Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Leu Leu Pro Asp Ala Lys Trp Ile Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Ile Ala Val Ala Ser Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Lys Leu Ser His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Gly Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Ala Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg 
    530                 535                 540                 


Glu Leu Thr Gly Trp Asp Val Gly Val Gly Arg Phe Leu Thr Glu Glu 
545                 550                 555                 560 


Lys Ala Val Thr Thr Glu Glu Leu Ala Leu Leu Arg Thr Met Asp Pro 
                565                 570                 575     


Glu Gly Cys Tyr Arg 
            580     


<210>  366
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant13 of nonT polypeptide

<400>  366

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Arg Phe Val Arg Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Ser Met Ser Arg Pro Asn Ala Leu Ile Asn Ala Val Cys 
        35                  40                  45              


Lys Ala Phe Ala Gly Ser Lys Ser Leu Thr Val Ser Thr Thr Ala Val 
    50                  55                  60                  


His Ser Ser Ala His Ala Leu Ala Leu Ser Gly Ala Val Arg Arg Val 
65                  70                  75                  80  


Ile Ser Gly Phe Val Gly Asp Thr Phe Pro Ser Pro Arg Pro Asn Arg 
                85                  90                  95      


Leu Tyr Arg Glu Leu Ala Asp Gly Lys Pro Phe Glu Ile Glu Met Trp 
            100                 105                 110         


Ser Leu Leu Thr Tyr Thr Gln Arg Ile Met Ala Ala Ala Met Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Ser Met Leu Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Ala Ser Leu His Val Ile Ala His Pro Glu Asp Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Met Leu Ala Pro Leu Arg Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Val Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Glu Asp Glu Val Ile Ala Ala Met Pro 
    210                 215                 220                 


Asp Arg Val Val Ile Pro Ala Ala Arg Val Leu Gly Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Ser Leu Arg Thr Gly Gln Leu Gly Gly 
                245                 250                 255     


Ile Glu Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Ile Val Ser 
            260                 265                 270         


Ala Cys Lys Asp Pro Gln Thr Ala Ala Ala Tyr Tyr Glu Gln Trp Val 
        275                 280                 285             


Gly Gly Val Ala Ser His Ala Glu Tyr Leu Glu Arg Leu Gly Glu Asn 
    290                 295                 300                 


Arg Arg Ala Ala Leu Leu Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Asp Val Ser Thr Ala Pro Ser Glu Gln Glu Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Lys Thr Val Ala Asp Leu Val Arg Glu Arg 
            340                 345                 350         


Gly Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Gly 
        355                 360                 365             


Trp Val Ala Ala Arg Leu Val Ala Arg Asp Gly Val Gln Val Arg Leu 
    370                 375                 380                 


Ala Ala Glu Leu Gly Leu Gln Ser Met Asp Pro Asp Gly Gly Asp Val 
385                 390                 395                 400 


Phe Leu Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Val Ser Gly 
                405                 410                 415     


Val Ala Asp Ser Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu 
            420                 425                 430         


Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Leu Ile Pro Asp Gly Arg Phe Val Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Val Ala Val Ala Thr Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Gly Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Trp Ile Pro Pro Val Ala Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Lys 
    530                 535                 540                 


Glu Leu Thr Gly Trp Asp Val Gly Val Gly Arg Phe Leu Thr Asp Glu 
545                 550                 555                 560 


Lys Ala Val Thr Thr Glu Glu Leu Ala Ile Leu Arg Thr Met Asp Pro 
                565                 570                 575     


Glu Gly Cys Phe Arg 
            580     


<210>  367
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant14 of nonT polypeptide

<400>  367

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Arg Phe Val Lys Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Thr Leu Ser Arg Pro Asn Ala Leu Leu Asn Ala Val Cys 
        35                  40                  45              


Arg Ala Phe Ala Gly Ser Arg Ser Leu Thr Val Ser Thr Thr Ala Val 
    50                  55                  60                  


His Thr Ser Gly His Ala Leu Ala Leu Ser Gly Ala Val Arg Arg Leu 
65                  70                  75                  80  


Ile Ser Gly Phe Ile Gly Glu Ser Phe Pro Ser Pro Arg Pro Asn Lys 
                85                  90                  95      


Ile Phe Arg Glu Met Ala Asp Ala Lys Pro Phe Glu Ile Glu Met Trp 
            100                 105                 110         


Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met Ala Ala Ala Met Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Thr Met Ile Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Gly Ser Ile His Leu Val Ala His Pro Glu Asp Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Leu Leu Ala Pro Leu Lys Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Ile Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Glu Asp Glu Val Ile Ala Ala Met Pro 
    210                 215                 220                 


Glu Arg Val Ile Ile Pro Gly Ala Arg Val Leu Ala Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Ser Ile Arg Thr Gly Gln Val Ala Gly 
                245                 250                 255     


Ile Asp Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Glu Ile Val Ser 
            260                 265                 270         


Ala Cys Arg Asp Pro Gln Thr Ala Ala Ala Trp Tyr Glu Gln Trp Ile 
        275                 280                 285             


Gly Gly Val Gly Ser His Ala Glu Tyr Leu Glu Arg Ile Gly Glu Gln 
    290                 295                 300                 


Arg Arg Ala Ala Leu Leu Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Asp Val Thr Thr Ala Pro Ser Asp Gln Asp Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Lys Thr Val Ala Glu Leu Val Arg Glu Lys 
            340                 345                 350         


Ala Tyr Asp Thr Leu Leu Ala Gly Ile Gly Thr Ser His Leu Ser Ala 
        355                 360                 365             


Trp Leu Ala Ala Arg Leu Leu Ala Arg Asp Gly Val Gln Val Arg Met 
    370                 375                 380                 


Ala Ala Glu Leu Gly Leu Gln Ser Leu Asp Pro Glu Ala Gly Asp Val 
385                 390                 395                 400 


Phe Val Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Thr Gly 
                405                 410                 415     


Val Ala Glu Ser Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Ile 
            420                 425                 430         


Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Leu Leu Pro Asp Gly Lys Trp Leu Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Val Gly Val Ala Ser Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Ala Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Trp Leu Pro Pro Val Ala Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Arg 
    530                 535                 540                 


Glu Met Thr Gly Trp Asp Val Gly Val Ala Arg Phe Leu Thr Glu Glu 
545                 550                 555                 560 


Arg Ala Val Thr Thr Glu Glu Leu Ala Leu Leu Arg Thr Leu Asp Pro 
                565                 570                 575     


Glu Gly Cys Phe Arg 
            580     


<210>  368
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant15 of nonT polypeptide

<400>  368

Met Thr Thr Ala Pro Val Arg Pro Ser Val Pro His Leu Ala Ala Gly 
1               5                   10                  15      


Pro Asp Glu Leu Val Arg Lys Phe Val Lys Glu Gly Asp His Val His 
            20                  25                  30          


Ala Ala Ala Thr Ile Ser Arg Pro Asn Ala Leu Leu Gln Ala Val Cys 
        35                  40                  45              


Arg Ala Phe Ala Gly Ser Lys Ser Leu Thr Val Ser Ser Thr Ala Val 
    50                  55                  60                  


His Ser Ser Ala His Ala Leu Ala Val Ser Gly Ala Val Lys Lys Val 
65                  70                  75                  80  


Ile Thr Gly Phe Val Gly Glu Thr Tyr Pro Ser Pro Arg Pro Asn Arg 
                85                  90                  95      


Leu Tyr Arg Glu Leu Ala Glu Gly Lys Pro Phe Glu Val Glu Leu Trp 
            100                 105                 110         


Ser Leu Leu Ser Tyr Ser Gln Arg Leu Met Ala Ala Ala Leu Gly Gln 
        115                 120                 125             


Pro Phe Ala Thr Thr Gly Ser Met Val Ala Glu Thr Asp Leu Arg His 
    130                 135                 140                 


Gly Lys Glu Gly Ser Leu His Leu Val Ala His Pro Glu Asp Pro Glu 
145                 150                 155                 160 


Arg Ser Val Thr Leu Leu Ala Pro Leu Lys Pro Arg Phe Thr Leu Phe 
                165                 170                 175     


His Gly Val Cys Ala Asp Arg Arg Gly Asn Val Val Ala Val Pro Pro 
            180                 185                 190         


Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala Ala Thr Glu Gly Val Leu 
        195                 200                 205             


Ala Ser Val Glu Ala Ile Val Asp Asp Glu Val Ile Gly Ala Met Pro 
    210                 215                 220                 


Glu Arg Val Leu Ile Pro Ala Ala Arg Val Leu Gly Leu Cys Glu Ala 
225                 230                 235                 240 


Pro Leu Gly Ala His Pro Gln Ser Ile Arg Thr Ala Gln Val Gly Gly 
                245                 250                 255     


Ile Asp Gly Tyr Leu Asp Asp Tyr Ala Phe Leu Thr Asp Leu Val Ser 
            260                 265                 270         


Ala Cys Lys Asp Pro Gln Thr Ala Ala Ala Tyr Tyr Glu Gln Phe Val 
        275                 280                 285             


Gly Gly Val Ala Ser His Ala Glu Tyr Val Asp Arg Val Gly Glu Gln 
    290                 295                 300                 


Lys Arg Ala Ala Ile Leu Phe Pro Ala Pro Pro Gly Pro Pro Ala Gln 
305                 310                 315                 320 


Gly Pro Ala Pro Ala Glu Val Ser Thr Ala Pro Thr Glu Gln Glu Gln 
                325                 330                 335     


Leu Ile Val Leu Gly Ala Lys Thr Val Ala Glu Leu Val Arg Glu Lys 
            340                 345                 350         


Gly Tyr Glu Thr Leu Leu Ala Gly Ile Gly Thr Ser His Met Ser Ala 
        355                 360                 365             


Trp Leu Ala Ala Arg Leu Leu Ala Arg Asp Gly Val Asn Val Lys Val 
    370                 375                 380                 


Ala Gly Glu Leu Gly Leu Gln Ser Leu Asp Pro Glu Ala Gly Glu Val 
385                 390                 395                 400 


Phe Ile Phe Ser Gln Arg His Ala Glu Arg Ser Gln Met Leu Thr Ala 
                405                 410                 415     


Met Ala Glu Ser Leu Gly Gly Ala Val Ala Ala Asn Pro Arg Cys Leu 
            420                 425                 430         


Gly Val Leu Ser Ala Ala Glu Ile Asp Pro Asp Ala Asn Ile Asn Thr 
        435                 440                 445             


Thr Met Leu Pro Glu Gly Lys Trp Ile Thr Gly Ser Gly Gly Ala Asn 
    450                 455                 460                 


Asp Ile Ala Ser Ser Val Asp Cys Val Val Leu Ala Val Ala Thr Pro 
465                 470                 475                 480 


Arg Arg Tyr Val Pro Arg Leu Thr His Leu Thr Ser Pro Gly Leu His 
                485                 490                 495     


Val Arg Asp Val Val Ser Gln Phe Gly Arg Phe Ala Arg Thr Ala Pro 
            500                 505                 510         


Gly Thr Pro Phe Glu Leu Thr Ser Tyr Ile Pro Pro Val Gly Gly Arg 
        515                 520                 525             


Gly Arg Thr Ala Glu Asp Leu Pro Asp Gly Pro Glu Ala Ala Val Lys 
    530                 535                 540                 


Glu Leu Thr Gly Trp Glu Val Gly Val Ala Arg Phe Leu Thr Asp Glu 
545                 550                 555                 560 


Lys Ala Val Thr Thr Glu Glu Leu Ala Leu Leu Arg Thr Met Asp Pro 
                565                 570                 575     


Asp Gly Cys Tyr Arg 
            580     


<210>  369
<211>  1788
<212>  DNA
<213>  Streptomyces sp. W007

<400>  369
atgaccaccg ccctcgaaca ccccgccacc atcggccccc tgccgggccc ctacctggcc       60

accggccccg acgacctgat acgccgcttc gtccgcgagg gcgaccacgt gcacgccgcg      120

gcgacgatgt cacggcccaa cgccctgctg aacgcggtgt gccgggcctt cgccgggagc      180

ggcagcatga cggtgagcac caccgccgtg cactccagcg cccatgcgct ggccctctcc      240

ggcgccgtac gcaaggtgat caccggcttc gtcggcgaca cctacccctc accgcgcccc      300

aaccgcctct accgcgagct ggccgagggc cggccgttcg aggtggagat gtggtcgctg      360

ctgagctaca cgcagcggct gatggccggg gcgctcggcc agcccttcgc caccaccggc      420

tcgatgctcg ccgagaccga cctccggcac ggcaaggagg gcaagctcca cctggtgccg      480

caccccgagg acccggagcg caccgtcacc ctgctcagcc cgctgcgccc gcgtttcacc      540

ctcttccacg gtgtcgccgc cgaccgccgg ggcaacgtcg tggcctgtcc cccgctgggc      600

gagggcgcct gggccgcgta cgccgccacc gagggtgtcc tcgcctccgt ggaggcgatc      660

gtcgacgacg aggtgatcgc cgcgatgccg gaccgggtgg tgatccccgc cgcccgcgtc      720

ctcggcctgt gcgaggcgcc gctcggcgcc cacccgcagt cgctgcgcac gggtggactg      780

gccggagtcg acggctacct ggacgactac ggcttcctca ccgacatcgt ggccgcctgc      840

aaggacccgg agaccgccgc cgcctggtac gagacgtggg tcggcggggt ggggagccac      900

gccggctacc tggagcggct gggcggtacg cgccgcgccg cgctggtgtt ccccgctccc      960

ccgggcgtcc cggtcgccgt ggagaaggac cggggcccgg cggacgggtc cgccgccccc     1020

accgagcagg agcagctcat cgtgctcggc gcccgcgcga tcgtcgacct ggtccgggag     1080

cgcggctacg acacgctgct cgccgggatc ggcacctcgc acatgtccgc gtggctggcg     1140

gcccggctgt tgggacgcga cggcgtccag gtgcaggtgg ccgccgagct gggcctccag     1200

tcgatggacc ccgagcccgg cgacgtcttc ctcttcagcc aacggcacgc cgagcgctcg     1260

cagatgctgg cgggcgtcgc ggagacgctg ggcggcgcgg tcgccgccaa cccgcgctgc     1320

ctgggcgtgc tctccgccgc ggagatcgac ccggacgcca acatcaacac gacgctgctg     1380

cccgacggcc gctggatcac cggctccggc ggggccaacg acatcgcctc gtccgtggac     1440

tgcgtggtga tcgcggtcgc ctcggcccgc cgctacgtac cgcggctgac ccacctcacc     1500

agtccgggcc tgcgggtccg cgacgtggtc agccagttcg ggcgcttcac ccgtgccggg     1560

gccggcgccg ccttcgagct ggcgagctgg ctgccgcccg ttccgggccg cggccgcacc     1620

gggaaggacc tccccgacgg gccggagggg gcggttcgcg acctcaccgg ctgggatttc     1680

cccgaggcct ccaccggggt cagcggcttc ctgaccgacg agaaggccgt cagcaccgaa     1740

gaactcgtcc tcctgcgcac catggacccg gaaggtttct accgatga                  1788


<210>  370
<211>  595
<212>  PRT
<213>  Streptomyces sp. W007

<400>  370

Met Thr Thr Ala Leu Glu His Pro Ala Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Arg 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Asn Ala Val Cys Arg Ala Phe Ala Gly Ser Gly Ser Met Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Cys Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Gly Phe 
            260                 265                 270         


Leu Thr Asp Ile Val Ala Ala Cys Lys Asp Pro Glu Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Thr Trp Val Gly Gly Val Gly Ser His Ala Gly Tyr Leu 
    290                 295                 300                 


Glu Arg Leu Gly Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Val Ala Val Glu Lys Asp Arg Gly Pro Ala Asp Gly 
                325                 330                 335     


Ser Ala Ala Pro Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Asp Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Leu 
    370                 375                 380                 


Gly Arg Asp Gly Val Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln 
385                 390                 395                 400 


Ser Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His 
                405                 410                 415     


Ala Glu Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg 
    450                 455                 460                 


Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Gly Ala Val Arg Asp Leu Thr Gly Trp Asp Phe 
545                 550                 555                 560 


Pro Glu Ala Ser Thr Gly Val Ser Gly Phe Leu Thr Asp Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Glu Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly 
            580                 585                 590         


Phe Tyr Arg 
        595 


<210>  371
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant16 of nonT polypeptide

<400>  371

Met Thr Thr Ala Leu Glu His Pro Ala Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Lys 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Ile Asn Ala Val Cys Arg Ala Phe Ala Gly Ser Gly Ser Met Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Ile Ile Ser Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Lys Leu Tyr Arg Asp Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Ile Glu Leu Trp Ser Leu Leu Ser Tyr Ser Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Lys 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Lys Gly Asn 
            180                 185                 190         


Val Val Ala Cys Pro Pro Leu Ala Glu Ala Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Phe 
            260                 265                 270         


Leu Thr Asp Ile Val Ala Ala Cys Lys Asp Pro Glu Thr Ala Ala Ala 
        275                 280                 285             


Phe Tyr Glu Thr Phe Val Gly Gly Val Gly Ser His Ala Gly Tyr Leu 
    290                 295                 300                 


Glu Lys Leu Gly Gly Ser Arg Arg Ala Ala Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Val Ala Val Glu Lys Asp Arg Gly Pro Ala Asp Gly 
                325                 330                 335     


Thr Ala Ala Pro Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Asp Leu Val Arg Asp Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Ile 
    370                 375                 380                 


Gly Arg Asp Gly Met Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln 
385                 390                 395                 400 


Ser Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Lys His 
                405                 410                 415     


Ala Glu Arg Thr Gln Met Leu Ala Gly Val Ala Glu Thr Leu Ala Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg 
    450                 455                 460                 


Trp Val Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Lys Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Asp Phe 
545                 550                 555                 560 


Pro Glu Ala Ser Thr Gly Val Ser Gly Phe Leu Thr Asp Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Glu Glu Leu Val Leu Leu Arg Ser Leu Asp Pro Glu Gly 
            580                 585                 590         


Phe Tyr Arg 
        595 


<210>  372
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant17 of nonT polypeptide

<400>  372

Met Thr Thr Ala Leu Glu His Pro Ala Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Ser Gly Pro Glu Asp Leu Ile Arg Arg Phe Val Arg 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Gln Ala Val Cys Lys Ala Phe Ala Gly Ser Gly Ser Met Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Arg Leu Tyr Arg Glu Met Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Leu Trp Ser Leu Leu Ser Tyr Thr Gln Lys Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Val Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Cys Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Glu Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Ile Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Ala Tyr Leu Asp Asp Tyr Gly Tyr 
            260                 265                 270         


Leu Thr Glu Ile Val Gly Ala Cys Lys Asp Pro Glu Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Thr Trp Val Gly Gly Val Gly Ser His Gly Gly Tyr Leu 
    290                 295                 300                 


Glu Arg Leu Gly Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Val Ala Val Glu Lys Asp Arg Gly Pro Ala Asp Gly 
                325                 330                 335     


Ser Ala Ala Pro Ser Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Asp Leu Val Lys Glu Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Ile Ser Ala Trp Leu Ala Ala Arg Val Leu 
    370                 375                 380                 


Gly Arg Asp Gly Met Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln 
385                 390                 395                 400 


Ser Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His 
                405                 410                 415     


Ala Glu Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Val Ile Pro Asp Gly Lys 
    450                 455                 460                 


Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Ser Ala Lys Arg Tyr Val Pro Arg Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Gly Gly Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Gly Ala Val Lys Asp Leu Thr Gly Trp Asp Phe 
545                 550                 555                 560 


Pro Glu Ala Ser Thr Gly Val Ser Ala Phe Leu Thr Glu Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Glu Glu Leu Val Leu Leu Arg Thr Met Asp Pro Asp Gly 
            580                 585                 590         


Phe Phe Arg 
        595 


<210>  373
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant18 of nonT polypeptide

<400>  373

Met Thr Thr Ala Leu Glu His Pro Ala Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Ser Gly Pro Glu Asp Leu Ile Arg Arg Phe Val Arg 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Gln Ala Val Cys Lys Ala Phe Ala Gly Ser Gly Ser Met Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Arg Leu Tyr Arg Glu Met Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Leu Trp Ser Leu Leu Ser Tyr Thr Gln Lys Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Val Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Cys Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Glu Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Ile Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Ala Tyr Leu Asp Asp Tyr Gly Tyr 
            260                 265                 270         


Leu Thr Glu Ile Val Gly Ala Cys Lys Asp Pro Glu Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Thr Trp Val Gly Gly Val Gly Ser His Gly Gly Tyr Leu 
    290                 295                 300                 


Glu Arg Leu Gly Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Val Ala Val Glu Lys Asp Arg Gly Pro Ala Asp Gly 
                325                 330                 335     


Ser Ala Ala Pro Ser Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Asp Leu Val Lys Glu Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Ile Ser Ala Trp Leu Ala Ala Arg Val Leu 
    370                 375                 380                 


Gly Arg Asp Gly Met Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln 
385                 390                 395                 400 


Ser Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His 
                405                 410                 415     


Ala Glu Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Val Ile Pro Asp Gly Lys 
    450                 455                 460                 


Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Ser Ala Lys Arg Tyr Val Pro Arg Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Gly Gly Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Gly Ala Val Lys Asp Leu Thr Gly Trp Asp Phe 
545                 550                 555                 560 


Pro Glu Ala Ser Thr Gly Val Ser Ala Phe Leu Thr Glu Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Glu Glu Leu Val Leu Leu Arg Thr Met Asp Pro Asp Gly 
            580                 585                 590         


Phe Phe Arg 
        595 


<210>  374
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant19 of nonT polypeptide

<400>  374

Met Thr Thr Ala Leu Glu His Pro Gly Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Thr Gly Pro Asp Asp Leu Ile Arg Arg Phe Val Lys 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Ser Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Ile Asn Ala Val Cys Arg Ala Phe Ala Ala Ser Ala Ser Met Thr 
    50                  55                  60                  


Leu Ser Ser Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Thr 
65                  70                  75                  80  


Gly Ala Val Lys Lys Leu Ile Thr Gly Phe Ile Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Arg Ile Tyr Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Leu Trp Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Thr Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Val His Val Ile Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Leu Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Lys Gly Asn 
            180                 185                 190         


Val Ile Ala Cys Pro Pro Leu Gly Glu Ala Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Glu Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Glu Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Ala Leu Cys Glu Gly Pro Leu Gly Ala His Pro Asn Thr Val Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Ile Asp Asp Tyr Ala Phe 
            260                 265                 270         


Met Thr Glu Ile Val Ala Ala Cys Arg Asp Pro Glu Ser Gly Ala Ala 
        275                 280                 285             


Trp Tyr Glu Thr Phe Leu Ala Gly Val Gly Thr His Ala Gly Tyr Leu 
    290                 295                 300                 


Asp Lys Leu Gly Gly Thr Arg Arg Ala Ala Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Ile Ala Val Glu Lys Asp Arg Gly Pro Ala Asp Ala 
                325                 330                 335     


Ser Ala Ala Pro Ser Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Glu Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Ala Arg Val Leu 
    370                 375                 380                 


Gly Lys Asp Gly Val Gln Val Gln Val Ala Ala Glu Leu Gly Leu Gln 
385                 390                 395                 400 


Ser Leu Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His 
                405                 410                 415     


Ala Glu Arg Ser Gln Met Leu Ala Gly Val Ala Asp Thr Leu Ala Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Leu Ile Pro Asp Gly Arg 
    450                 455                 460                 


Trp Val Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Ser Ala Arg Arg Tyr Val Pro Lys Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Ala Ala Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Gly Ala Val Arg Asp Leu Thr Gly Trp Glu Phe 
545                 550                 555                 560 


Pro Asp Gly Ser Thr Gly Val Ser Gly Phe Leu Thr Asp Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Glu Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly 
            580                 585                 590         


Phe Tyr Arg 
        595 


<210>  375
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant20 of nonT polypeptide

<400>  375

Met Thr Thr Ala Leu Glu His Pro Ala Thr Ile Gly Pro Leu Pro Gly 
1               5                   10                  15      


Pro Tyr Val Ala Thr Gly Pro Glu Asp Leu Ile Lys Arg Phe Val Lys 
            20                  25                  30          


Glu Gly Asp His Val His Ala Ala Ala Thr Ile Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Ile Asn Ala Val Cys Arg Ala Phe Ala Gly Thr Gly Ser Met Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Thr Ser Gly His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Met Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ser Pro Arg Pro Asn Arg Val Tyr Arg Asp Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Leu Glu Leu Trp Ser Leu Leu Thr Tyr Thr Gln Arg Ile Met 
        115                 120                 125             


Ala Gly Ala Val Gly Gln Pro Phe Ala Thr Thr Gly Thr Met Val Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Lys Leu His Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Leu Thr Leu Leu Ser Pro Leu Lys 
                165                 170                 175     


Pro Arg Phe Thr Leu Phe His Gly Val Ala Ala Asp Arg Lys Gly Asn 
            180                 185                 190         


Val Val Ala Cys Pro Pro Leu Gly Asp Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Ala Leu Cys Glu Ala Pro Ile Gly Gly His Pro Gln Thr Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Val Asp Asp Tyr Ala Tyr 
            260                 265                 270         


Val Thr Glu Ile Leu Gly Ala Cys Lys Asp Pro Glu Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Thr Trp Val Gly Gly Leu Gly Ser His Gly Gly Phe Leu 
    290                 295                 300                 


Glu Lys Val Gly Gly Thr Arg Arg Ala Ala Leu Ile Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Val Pro Val Ala Val Glu Lys Asp Lys Gly Pro Ala Glu Gly 
                325                 330                 335     


Ser Ala Ala Pro Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg 
            340                 345                 350         


Ala Ile Val Asp Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala 
        355                 360                 365             


Gly Ile Gly Thr Ser His Met Ser Ala Trp Val Ala Ala Arg Ile Ile 
    370                 375                 380                 


Gly Arg Asp Gly Val Asn Val Gln Val Ala Ala Glu Leu Gly Ile Gln 
385                 390                 395                 400 


Ser Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Lys His 
                405                 410                 415     


Ala Glu Arg Ser Gln Met Val Ala Gly Val Ala Glu Thr Leu Gly Gly 
            420                 425                 430         


Ala Val Ala Ala Asn Pro Arg Cys Ile Ala Val Leu Ser Ala Ala Glu 
        435                 440                 445             


Ile Asp Pro Asp Ala Asn Ile Asn Thr Thr Leu Val Pro Asp Gly Arg 
    450                 455                 460                 


Trp Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser Val Asp 
465                 470                 475                 480 


Cys Val Val Ile Ala Val Ala Thr Ala Arg Arg Tyr Val Pro Arg Leu 
                485                 490                 495     


Thr His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln 
            500                 505                 510         


Phe Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Ala 
        515                 520                 525             


Ser Trp Ile Pro Pro Val Pro Gly Arg Gly Arg Thr Gly Lys Asp Leu 
    530                 535                 540                 


Pro Asp Gly Pro Glu Gly Ala Val Arg Asp Leu Thr Gly Phe Asp Phe 
545                 550                 555                 560 


Pro Glu Ala Ser Thr Gly Ile Ser Gly Phe Leu Thr Glu Glu Lys Ala 
                565                 570                 575     


Val Ser Thr Asp Glu Leu Val Leu Leu Arg Thr Met Asp Pro Glu Gly 
            580                 585                 590         


Phe Tyr Arg 
        595 


<210>  376
<211>  1785
<212>  DNA
<213>  Streptomyces californicus

<400>  376
atgaccacag cgcccgaacg tccctccgcc gccgaccgcc ccaccggccc ctacctggcc       60

gacggccccg acgacctggt acgccgcttc gtccgcgccg gtgaccacgt gcacgccgcg      120

gcgacgatgt cgcggcccaa cgccctgctg aacgcggtgt gccgcacctt cgcgggaagc      180

cgcagcctga ccgtgagcac caccgccgtg cactccagcg cacacgcgct ggccctctcc      240

ggagccgtac gcaaggtgat caccggcttc gtcggggaca cctaccccgc gccgcgcccc      300

aaccgcctct accgcgaact ggccgagggc aggccgttcg agatggagat gtggtcgctg      360

ctgagctaca cccagcggct gatggccggg gcgctcggcc agcccttcgc caccaccggc      420

tcgatgctcg ccgagaccga cctccggcac ggcaaggagg gcgtcctcca ccaggtgccg      480

caccccgagg acccggagcg cacggtcacc ctgctcagtc cgctgcgccc gcgcctcacc      540

ctcttccacg gcgtcgtcgc cgaccgccgg ggcaacgtcg tggccgttcc cccgctgggc      600

gagggcgcct gggccgcgta cgccgcgacc gacggcgtcc tcgcatcggt ggaggcgatc      660

gtcgacgacg aggtgatcgc ggcgatgccg gaccgggtgg tgatccccgc cgcccgcgtc      720

ctcgggctgt gcgaggcgcc gctcggcgcc cacccgcagt cgctgcgcac gggcgggctc      780

gccggggtgg acggctacct cgacgactac gcgttcctca ccgacatcgt ggccgcctgc      840

aagaccccgc agaccgccgc cgcctggtac gaggagtggg tcggcgggat acccgaccac      900

gccgcctacc tggagagact cggcgcgacg cgccgctccg aactggtctt ccccgctccc      960

ccgggcactg ccgccgcggg gaagaccccc tcacccgagg acctggacgc cgcgcccagc     1020

gagcaggagc agctgatcgt gctcggcgcc cgcgccgtcg cggacctggt gcgcgagcgc     1080

ggctacgaca cactgctcgc cgggatcggc acctcgcaca tgtcggcgtg gctggcggcc     1140

cggctgctgg cggacgaggg cgtccaggta cgggtggccg ccgagctggg cctgcagtcg     1200

atggaccccg agcccggcga cgtcttcctc ttcagccagc ggcacgcgga gcgctcgcag     1260

atgctggccg gggtcgcgga gacgctgggc ggcgcggtcg ccgccaaccc ccgctgcctg     1320

ggggtgctgt cggccgccga gatcgatccg ggcgccaaca tcaacaccac cctgctgccg     1380

gacggccggt ggatcaccgg ctccggcggg gccaacgaca tcgcctcctc cgtggactgc     1440

gtggtgatcg ccctcgcctc ggcccgccgc tacgtccccc ggctgaccca cctgaccagc     1500

ccgggcctgc gggtccgcga tgtggtcagc cagttcggcc gtttcacccg cgcgggggcc     1560

ggggccgcct tcgagctgac gagctggctg ccgccagtgc ccggccgggg ccgcacggag     1620

gccgacctgc cggacgggcc cgaggccgcc gtacgcgacc tcaccggctg ggacttcccc     1680

gacggctcca cgggggtcgg cgcgttcctg accgacgaga agtccgtcac caccgaagaa     1740

ctctcgctcc tgcgcaccat ggacccggaa ggcttctacc gatga                     1785


<210>  377
<211>  594
<212>  PRT
<213>  Streptomyces californicus

<400>  377

Met Thr Thr Ala Pro Glu Arg Pro Ser Ala Ala Asp Arg Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Asp Asp Leu Val Arg Arg Phe Val Arg 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Asn Ala Val Cys Arg Thr Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ala Pro Arg Pro Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Met Glu Met Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Val Leu His Gln Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Val Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Asp Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Phe 
            260                 265                 270         


Leu Thr Asp Ile Val Ala Ala Cys Lys Thr Pro Gln Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Glu Trp Val Gly Gly Ile Pro Asp His Ala Ala Tyr Leu 
    290                 295                 300                 


Glu Arg Leu Gly Ala Thr Arg Arg Ser Glu Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Ser Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Asp Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Leu Ala 
    370                 375                 380                 


Asp Glu Gly Val Gln Val Arg Val Ala Ala Glu Leu Gly Leu Gln Ser 
385                 390                 395                 400 


Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala 
                405                 410                 415     


Glu Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Gly Ala Asn Ile Asn Thr Thr Leu Leu Pro Asp Gly Arg Trp 
    450                 455                 460                 


Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Ile Ala Leu Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu Thr 
                485                 490                 495     


His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Thr Ser 
        515                 520                 525             


Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Asp Phe Pro 
545                 550                 555                 560 


Asp Gly Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Lys Ser Val 
                565                 570                 575     


Thr Thr Glu Glu Leu Ser Leu Leu Arg Thr Met Asp Pro Glu Gly Phe 
            580                 585                 590         


Tyr Arg 
        


<210>  378
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant21 of nonT polypeptide

<400>  378

Met Thr Thr Ala Pro Glu Arg Pro Ser Ala Ala Asp Arg Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Asp Asp Leu Val Arg Arg Phe Val Arg 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Gln Ala Val Cys Arg Thr Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Lys Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Gly Pro Arg Pro Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Met Glu Leu Trp Ser Leu Leu Ser Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Glu Leu Arg His Gly Lys Glu Gly Val Val His Gln Ile Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Asp Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Val Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Asp Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Leu Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Ala Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Thr Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Phe 
            260                 265                 270         


Leu Thr Asp Ile Val Ala Ala Cys Lys Thr Pro Asn Thr Ala Ala Ala 
        275                 280                 285             


Trp Phe Glu Glu Trp Val Gly Gly Ile Pro Asp His Ala Ala Phe Leu 
    290                 295                 300                 


Glu Arg Leu Gly Ala Ser Arg Arg Ser Glu Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Ser Glu Gln Asp Gln Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Asp Leu Val Lys Glu Arg Gly Tyr Asp Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Leu Ser Ala Trp Leu Ala Ala Arg Leu Leu Ala 
    370                 375                 380                 


Asp Glu Gly Val Gln Ile Arg Val Ala Ala Glu Leu Gly Leu Gln Ser 
385                 390                 395                 400 


Met Asp Pro Glu Pro Gly Asp Val Phe Ile Phe Ser Gln Arg His Ala 
                405                 410                 415     


Glu Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Val Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Gly Ala Asn Ile Asn Thr Thr Ile Leu Pro Asp Gly Lys Trp 
    450                 455                 460                 


Val Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Ile Ala Leu Ala Thr Ala Arg Arg Tyr Val Pro Arg Leu Ser 
                485                 490                 495     


His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Gly Gly Gly Ala Phe Glu Leu Thr Ser 
        515                 520                 525             


Trp Val Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Arg Asp Leu Thr Gly Trp Asp Phe Pro 
545                 550                 555                 560 


Asp Gly Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Lys Ser Val 
                565                 570                 575     


Thr Thr Glu Glu Leu Ser Leu Leu Arg Thr Met Asp Pro Glu Gly Phe 
            580                 585                 590         


Tyr Arg 
        


<210>  379
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant22 of nonT polypeptide

<400>  379

Met Thr Thr Ala Pro Glu Arg Pro Ser Ala Ala Asp Arg Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Glu Asp Leu Val Arg Arg Phe Val Arg 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Asn Ala Val Cys Lys Ser Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Ile Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Thr 
65                  70                  75                  80  


Gly Ala Val Arg Lys Leu Ile Thr Gly Phe Val Gly Asp Ser Tyr Pro 
                85                  90                  95      


Ala Pro Arg Pro Asn Arg Leu Tyr Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Met Glu Met Trp Ser Leu Leu Thr Tyr Ser Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Val Leu His Gln Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Ile Ala Val Pro Pro Leu Gly Glu Ala Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Asp Gly Val Leu Ala Ser Val Glu Ala Ile Val Glu Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Leu Arg 
                245                 250                 255     


Ser Ala Gly Leu Gly Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Tyr 
            260                 265                 270         


Ile Thr Asp Ile Val Ala Ala Cys Lys Thr Pro Gln Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Glu Trp Val Gly Gly Ile Pro Asp His Ala Ala Tyr Leu 
    290                 295                 300                 


Glu Arg Leu Gly Ala Thr Arg Arg Ser Glu Leu Ile Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Thr Glu Gln Asp Asn Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Asp Leu Val Arg Glu Arg Gly Tyr Asp Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Ala Arg Leu Leu Ala 
    370                 375                 380                 


Asp Glu Gly Val Gln Val Arg Val Ala Ala Glu Leu Gly Leu Gln Ser 
385                 390                 395                 400 


Met Asp Pro Glu Pro Gly Asp Val Phe Leu Tyr Ser Gln Arg His Ala 
                405                 410                 415     


Asp Arg Ser Gln Met Leu Ala Gly Val Ala Glu Thr Leu Gly Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Gly Ala Asn Ile Asn Thr Thr Val Leu Pro Glu Gly Arg Trp 
    450                 455                 460                 


Ile Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Val Ala Leu Ala Ser Ala Arg Arg Tyr Val Pro Arg Leu Thr 
                485                 490                 495     


His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Thr Ser 
        515                 520                 525             


Trp Val Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Lys Asp Leu Thr Gly Trp Asp Phe Pro 
545                 550                 555                 560 


Asp Gly Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Arg Ser Val 
                565                 570                 575     


Thr Thr Glu Glu Leu Ser Leu Leu Arg Thr Met Asp Pro Glu Gly Phe 
            580                 585                 590         


Tyr Arg 
        


<210>  380
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant23 of nonT polypeptide

<400>  380

Met Thr Thr Ala Pro Glu Arg Pro Ser Ala Ala Asp Lys Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Asp Asp Leu Val Arg Arg Phe Val Arg 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Thr Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Met Gln Ala Val Cys Arg Thr Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Val Ser Thr Thr Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Val Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ala Pro Arg Pro Asn Arg Leu Phe Arg Glu Leu Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Met Trp Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Met Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Val Ile His Gln Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Val Ala Leu Pro Pro Val Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Glu Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Glu Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Glu Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Gly His Pro Gln Ser Leu Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Phe 
            260                 265                 270         


Ile Thr Asp Ile Val Ala Ala Cys Lys Thr Pro Gln Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Glu Trp Val Gly Gly Val Pro Asp His Ala Gly Tyr Leu 
    290                 295                 300                 


Glu Arg Val Gly Gly Thr Arg Arg Ser Glu Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Thr Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Glu Leu Val Lys Glu Lys Gly Tyr Glu Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Ile Ser Ala Trp Leu Ala Ala Arg Leu Val Ala 
    370                 375                 380                 


Asp Glu Gly Val Gln Val Lys Val Ala Ala Glu Leu Gly Ile Gln Ser 
385                 390                 395                 400 


Met Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala 
                405                 410                 415     


Glu Arg Ser Gln Met Leu Ala Gly Val Ala Asp Thr Leu Gly Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Val Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Gly Ala Asn Ile Asn Thr Thr Met Leu Pro Asp Gly Arg Trp 
    450                 455                 460                 


Met Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Leu Ala Leu Ala Ser Ala Lys Arg Tyr Val Pro Arg Leu Ser 
                485                 490                 495     


His Leu Thr Ser Pro Gly Leu Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Ser Ser 
        515                 520                 525             


Trp Val Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Lys Glu Leu Thr Gly Trp Asp Phe Pro 
545                 550                 555                 560 


Asp Gly Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Arg Ser Val 
                565                 570                 575     


Thr Thr Asp Glu Leu Ser Leu Leu Arg Thr Val Asp Pro Glu Gly Phe 
            580                 585                 590         


Tyr Arg 
        


<210>  381
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant24 of nonT polypeptide

<400>  381

Met Thr Thr Ala Pro Asp Arg Pro Thr Ala Ala Asp Arg Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Glu Asp Leu Val Arg Arg Phe Val Lys 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Thr Met Ser Lys Pro Asn Ala 
        35                  40                  45              


Leu Val Asn Ala Val Cys Arg Ser Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Val Ser Ser Thr Ala Val His Thr Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Thr Gly Phe Ile Gly Asp Thr Tyr Pro 
                85                  90                  95      


Ala Pro Arg Pro Asn Lys Leu Tyr Arg Glu Leu Ala Glu Ala Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Leu Trp Ser Leu Leu Ser Tyr Thr Gln Arg Ile Met 
        115                 120                 125             


Ala Gly Ala Met Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Glu Gly Val Leu His Gln Leu Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Met Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Met Ala Asp Arg Lys Gly Asn 
            180                 185                 190         


Val Leu Ala Val Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Asp Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Leu Ile Ala Ala Met Pro Asp Arg Val Val Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Thr Met Arg 
                245                 250                 255     


Thr Ala Gly Ile Gly Gly Val Asp Gly Tyr Val Asp Asp Tyr Ala Phe 
            260                 265                 270         


Ile Thr Glu Ile Val Ala Ala Cys Lys Thr Pro Gln Thr Ala Ala Ala 
        275                 280                 285             


Tyr Tyr Glu Glu Phe Ile Ala Gly Ile Pro Asp His Ala Ala Tyr Leu 
    290                 295                 300                 


Glu Lys Leu Gly Gly Thr Arg Arg Ser Glu Ile Leu Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Ser Glu Gln Glu Gln Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Asp Ile Val Arg Asp Arg Gly Tyr Asp Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Met Ser Ala Trp Leu Ala Gly Arg Leu Val Ala 
    370                 375                 380                 


Asp Glu Gly Met Gln Leu Arg Val Ala Ala Glu Leu Gly Ile Gln Ser 
385                 390                 395                 400 


Leu Asp Pro Asp Pro Gly Asp Val Phe Met Phe Ser Gln Arg His Ala 
                405                 410                 415     


Glu Arg Ser Gln Met Leu Ala Gly Val Ala Asp Thr Leu Gly Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Ala Ala Asn Ile Asn Thr Thr Met Leu Pro Asp Gly Arg Trp 
    450                 455                 460                 


Val Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Ser Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Leu Ala Leu Ala Thr Ala Arg Arg Tyr Val Pro Arg Leu Thr 
                485                 490                 495     


His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Ala Gly Ala Ala Phe Glu Leu Thr Ser 
        515                 520                 525             


Trp Ile Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Arg Glu Leu Thr Gly Trp Asp Phe Pro 
545                 550                 555                 560 


Asp Ala Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Lys Ser Val 
                565                 570                 575     


Thr Thr Glu Glu Leu Ser Leu Leu Arg Thr Met Asp Pro Asp Gly Phe 
            580                 585                 590         


Phe Arg 
        


<210>  382
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant25 of nonT polypeptide

<400>  382

Met Thr Thr Ala Pro Glu Arg Pro Thr Ala Ala Asp Lys Pro Thr Gly 
1               5                   10                  15      


Pro Tyr Leu Ala Asp Gly Pro Glu Asp Leu Val Arg Arg Tyr Val Arg 
            20                  25                  30          


Ala Gly Asp His Val His Ala Ala Ala Ser Met Ser Arg Pro Asn Ala 
        35                  40                  45              


Leu Leu Gln Ala Val Cys Arg Thr Phe Ala Gly Ser Arg Ser Leu Thr 
    50                  55                  60                  


Leu Ser Ser Ser Ala Val His Ser Ser Ala His Ala Leu Ala Leu Ser 
65                  70                  75                  80  


Gly Ala Val Arg Lys Val Ile Ser Gly Phe Ile Gly Glu Ser Phe Pro 
                85                  90                  95      


Gly Pro Arg Pro Asn Arg Leu Tyr Arg Asp Met Ala Glu Gly Arg Pro 
            100                 105                 110         


Phe Glu Val Glu Met Tyr Ser Leu Leu Thr Tyr Thr Gln Arg Leu Met 
        115                 120                 125             


Ala Gly Ala Leu Gly Gln Pro Phe Ala Thr Thr Gly Ser Met Leu Ala 
    130                 135                 140                 


Glu Thr Asp Leu Arg His Gly Lys Asp Gly Val Leu His Gln Val Pro 
145                 150                 155                 160 


His Pro Glu Asp Pro Glu Arg Thr Val Thr Leu Leu Ser Pro Leu Arg 
                165                 170                 175     


Pro Arg Leu Thr Leu Phe His Gly Val Val Ala Asp Arg Arg Gly Asn 
            180                 185                 190         


Val Ile Ala Val Pro Pro Leu Gly Glu Gly Ala Trp Ala Ala Tyr Ala 
        195                 200                 205             


Ala Thr Asp Gly Val Leu Ala Ser Val Glu Ala Ile Val Asp Asp Glu 
    210                 215                 220                 


Val Ile Ala Ala Met Pro Asp Arg Val Ile Ile Pro Ala Ala Arg Val 
225                 230                 235                 240 


Leu Gly Leu Cys Glu Ala Pro Leu Gly Ala His Pro Gln Ser Val Arg 
                245                 250                 255     


Thr Gly Gly Leu Ala Gly Val Asp Gly Tyr Leu Asp Asp Tyr Ala Phe 
            260                 265                 270         


Ile Thr Glu Leu Val Ala Ala Cys Lys Thr Pro Gln Thr Ala Ala Ala 
        275                 280                 285             


Trp Tyr Glu Glu Trp Val Gly Ala Ile Pro Asp His Ala Gly Phe Leu 
    290                 295                 300                 


Glu Arg Val Gly Ala Thr Arg Arg Ser Glu Leu Val Phe Pro Ala Pro 
305                 310                 315                 320 


Pro Gly Thr Ala Ala Ala Gly Lys Thr Pro Ser Pro Glu Asp Leu Asp 
                325                 330                 335     


Ala Ala Pro Thr Glu Gln Asp Gln Leu Ile Val Leu Gly Ala Arg Ala 
            340                 345                 350         


Val Ala Asp Leu Val Arg Glu Lys Gly Tyr Glu Thr Leu Leu Ala Gly 
        355                 360                 365             


Ile Gly Thr Ser His Leu Ser Gly Tyr Leu Ala Ala Arg Ile Leu Ala 
    370                 375                 380                 


Asp Asp Gly Leu Asn Leu Lys Val Ala Ala Glu Leu Gly Leu Gln Ser 
385                 390                 395                 400 


Leu Asp Pro Glu Pro Gly Asp Val Phe Leu Phe Ser Gln Arg His Ala 
                405                 410                 415     


Asp Arg Ser Gln Met Val Ala Gly Val Ala Glu Thr Leu Ala Gly Ala 
            420                 425                 430         


Val Ala Ala Asn Pro Arg Cys Leu Gly Val Leu Ser Ala Ala Glu Ile 
        435                 440                 445             


Asp Pro Gly Ala Asn Ile Asn Thr Thr Met Leu Pro Asp Gly Lys Trp 
    450                 455                 460                 


Met Thr Gly Ser Gly Gly Ala Asn Asp Ile Ala Thr Ser Val Asp Cys 
465                 470                 475                 480 


Val Val Val Gly Leu Ala Thr Ala Arg Arg Tyr Val Pro Arg Leu Thr 
                485                 490                 495     


His Leu Thr Ser Pro Gly Val Arg Val Arg Asp Val Val Ser Gln Phe 
            500                 505                 510         


Gly Arg Phe Thr Arg Ala Gly Ala Ala Ala Ala Phe Glu Leu Thr Ser 
        515                 520                 525             


Trp Leu Pro Pro Val Pro Gly Arg Gly Arg Thr Glu Ala Asp Leu Pro 
    530                 535                 540                 


Asp Gly Pro Glu Ala Ala Val Arg Glu Leu Thr Gly Trp Glu Phe Pro 
545                 550                 555                 560 


Asp Gly Ser Thr Gly Val Gly Ala Phe Leu Thr Asp Glu Lys Ser Val 
                565                 570                 575     


Thr Thr Glu Glu Leu Ser Leu Leu Arg Thr Leu Asp Pro Glu Gly Phe 
            580                 585                 590         


Tyr Arg 
        


<210>  383
<211>  909
<212>  DNA
<213>  Streptomyces fulvissimus

<400>  383
gtgtctgatc agtcattctc cttgcccagt acgggtgttc gcggcaccgc actggtcacc       60

ggcggcagcc ggggcctcgg cgcggccatc gcccggcatc tggcctccgt cggctggcac      120

accgtgatct gcgggcgcga caccgagagc ctggacgcgg ccgtcaaggc ggcggccgac      180

gacgggctcg tgctccacgc cgtacgggcg gacgtcaccg acgaacggtc ggtggccgcc      240

ctcttcgagc ggctggccga ggacgcccca ccgctcgggc tctgcgtcaa caacgccggg      300

aacaacttct cccgccgcct ggtgagcgtc aaggaacagc cggacggccc gccactgctc      360

tccgcgcatc cgctggagga cttcgagcgg gtggtgacgt ccctgctcac cggcaccttc      420

ctagtcggcc gccacgcggc gcaggcgatg ctggccgccg gtacgcccgg cgccatcgtc      480

aacatctcct ccaccgtccg ccacggctcg tacgggcagt cggcgtactg cgcggccaag      540

tccggggtgg aggcgctgac ccggacctgg gcggtcgagc tgggcgagta cggcatccgg      600

gtcagcgcgg tggcgcccgg agtcatcgac ggcgaggcgc tgcgccgccg ttcggcggcg      660

agcgagcggc acgcggcgta catggccgac ctccggcgcc atgtgccgct gcgccgctgg      720

tgcgacgaga gggacgtggc ggaggcggtc gccttcgccg cggacaaccc ctcggtgacc      780

ggcaccgtgc tggaggtcga cgggggcgga ctgcccgccc gcgtcctgcc cccggccggc      840

cggaccgccg gggcgagcac gacagccgcg agcgcggacc tccccgagaa agcggagaac      900

acagcatga                                                              909


<210>  384
<211>  302
<212>  PRT
<213>  Streptomyces fulvissimus

<400>  384

Val Ser Asp Gln Thr Tyr Ser Leu Pro Ser Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Arg 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Val Ile Cys Gly Arg Asp Thr 
        35                  40                  45              


Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Glu Gly Leu Val 
    50                  55                  60                  


Val His Ala Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala Ala 
65                  70                  75                  80  


Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Val Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Asn Tyr Ser Arg Arg Leu Val Ser Val Lys Glu 
            100                 105                 110         


Gln Pro Asp Ala Pro Pro Leu Leu Ser Ala His Pro Leu Glu Asp Phe 
        115                 120                 125             


Glu Arg Leu Val Ser Ser Leu Leu Thr Gly Thr Phe Leu Val Gly Arg 
    130                 135                 140                 


His Ala Gly Gln Ala Met Leu Ala Ala Gly Ser Pro Gly Ala Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Thr Val Arg His Gly Ser Tyr Gly Gln Ser Ala Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala Ile 
            180                 185                 190         


Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly Leu 
        195                 200                 205             


Ile Asp Gly Glu Ala Ile Arg Arg Arg Ser Ala Ala Ser Glu Arg His 
    210                 215                 220                 


Ala Ala Tyr Met Ala Glu Val Arg Arg His Val Pro Leu Arg Arg Trp 
225                 230                 235                 240 


Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Ala Arg Val Leu Pro Pro Ala Gly Arg Thr Ala Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Ala Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  385
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant1 of nonO polypeptide

<400>  385

Val Ser Asp Gln Ser Phe Ser Leu Pro Ser Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Arg 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Val Ile Cys Gly Arg Asp Thr 
        35                  40                  45              


Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu Val 
    50                  55                  60                  


Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala Ala 
65                  70                  75                  80  


Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys Glu 
            100                 105                 110         


Gln Pro Asp Gly Pro Pro Leu Leu Ser Ala His Pro Leu Glu Asp Phe 
        115                 120                 125             


Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly Arg 
    130                 135                 140                 


His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Thr Val Arg His Gly Ser Tyr Gly Gln Ser Ala Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala Val 
            180                 185                 190         


Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly Val 
        195                 200                 205             


Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg His 
    210                 215                 220                 


Ala Ala Tyr Met Ala Asp Leu Arg Arg His Val Pro Leu Arg Arg Trp 
225                 230                 235                 240 


Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Ala Arg Val Leu Pro Pro Ala Gly Arg Thr Ala Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Ala Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  386
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant2 of nonO polypeptide

<400>  386

Val Ser Asp Gln Ser Phe Ser Leu Pro Ser Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Arg 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Val Ile Cys Gly Arg Asp Thr 
        35                  40                  45              


Asp Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu Val 
    50                  55                  60                  


Ile His Ala Val Arg Ala Asp Val Thr Asp Asp Arg Ser Val Ala Ala 
65                  70                  75                  80  


Leu Phe Glu Arg Leu Ala Asp Asp Ala Pro Pro Leu Gly Ile Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Ile Lys Glu 
            100                 105                 110         


Gln Pro Asp Gly Pro Pro Leu Leu Ser Ala His Pro Leu Glu Asp Phe 
        115                 120                 125             


Asp Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly Arg 
    130                 135                 140                 


His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Thr Val Arg His Gly Ser Tyr Gly Gln Ser Gly Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala Ile 
            180                 185                 190         


Glu Leu Ala Asp Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly Val 
        195                 200                 205             


Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg His 
    210                 215                 220                 


Ala Gly Tyr Val Ala Asp Leu Arg Arg His Met Pro Leu Arg Arg Trp 
225                 230                 235                 240 


Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Ser Leu Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Ala Arg Val Leu Pro Pro Ala Gly Arg Thr Ala Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Gly Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  387
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant3 of nonO polypeptide

<400>  387

Val Ser Asp Gln Ser Phe Ser Met Pro Ser Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Arg 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Val Ile Cys Ala Arg Asp Thr 
        35                  40                  45              


Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Val Val 
    50                  55                  60                  


Val His Ala Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Gly Ala 
65                  70                  75                  80  


Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys Asp 
            100                 105                 110         


Asn Pro Asp Gly Pro Pro Leu Leu Ser Gly His Pro Leu Glu Asp Phe 
        115                 120                 125             


Glu Arg Val Leu Thr Ser Leu Leu Thr Gly Thr Trp Leu Val Ala Lys 
    130                 135                 140                 


His Ala Ala Gln Ala Met Leu Ala Ala Ala Thr Pro Gly Ala Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Thr Val Arg His Gly Ser Tyr Ala Gln Ser Ala Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala Val 
            180                 185                 190         


Glu Met Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly Val 
        195                 200                 205             


Ile Asp Gly Glu Ala Ile Arg Arg Arg Ser Ala Ala Ser Glu Arg His 
    210                 215                 220                 


Ala Ala Tyr Ile Ala Asp Leu Arg Arg His Val Pro Met Lys Arg Trp 
225                 230                 235                 240 


Cys Glu Glu Arg Asp Val Ala Asp Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Gly Arg Val Leu Pro Pro Ala Gly Arg Thr Ala Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Ala Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  388
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant4 of nonO polypeptide

<400>  388

Val Ser Asp Gln Ser Phe Ser Leu Pro Thr Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Lys 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Ile Ile Cys Ala Arg Asp Thr 
        35                  40                  45              


Glu Ser Leu Asp Ala Ala Leu Arg Ala Ala Ala Asp Asp Gly Leu Val 
    50                  55                  60                  


Leu His Ala Val Lys Ala Asp Val Thr Asp Glu Arg Ser Val Ala Ala 
65                  70                  75                  80  


Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Ile Ser Val Arg Asp 
            100                 105                 110         


Gln Pro Asp Gly Pro Pro Leu Ile Thr Ala His Pro Val Glu Glu Trp 
        115                 120                 125             


Glu Arg Leu Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Ala Lys 
    130                 135                 140                 


His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Gly Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Thr Val Arg His Gly Ser Tyr Gly Asn Thr Ala Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Gly Leu Thr Arg Thr Trp Ala Val 
            180                 185                 190         


Glu Leu Ala Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly Val 
        195                 200                 205             


Ile Asp Gly Asp Ile Ile Arg Arg Arg Ser Ala Ala Ser Asp Arg His 
    210                 215                 220                 


Ala Ala Tyr Met Ala Asp Leu Lys Arg His Val Pro Leu Arg Arg Tyr 
225                 230                 235                 240 


Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Ser Leu Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Ala Arg Val Leu Pro Pro Ala Gly Arg Thr Gly Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Ala Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  389
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant5 of nonO polypeptide

<400>  389

Val Ser Asp Gln Ser Phe Ser Leu Pro Ser Thr Gly Val Arg Gly Thr 
1               5                   10                  15      


Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala Arg 
            20                  25                  30          


His Leu Ala Ser Val Gly Trp His Thr Met Ile Cys Gly Arg Asp Ser 
        35                  40                  45              


Glu Ser Leu Asp Ala Ala Val Lys Gly Ala Ala Glu Asp Gly Leu Val 
    50                  55                  60                  


Val His Ala Val Lys Ala Asp Val Thr Asp Asp Lys Ser Val Ala Ala 
65                  70                  75                  80  


Leu Phe Asp Lys Leu Gly Glu Asp Ala Pro Pro Leu Gly Leu Cys Val 
                85                  90                  95      


Asn Asn Ala Gly Asn Gln Phe Thr Arg Arg Leu Val Thr Val Lys Asp 
            100                 105                 110         


Gln Pro Asp Gly Pro Pro Leu Leu Ser Ala His Pro Leu Glu Asp Trp 
        115                 120                 125             


Asp Arg Met Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Ala Arg 
    130                 135                 140                 


His Ala Ala Gln Gly Met Val Ala Ala Gly Thr Pro Gly Ala Ile Val 
145                 150                 155                 160 


Asn Ile Ser Ser Ser Val Arg His Gly Ser Tyr Gly Gln Ser Ala Tyr 
                165                 170                 175     


Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala Val 
            180                 185                 190         


Glu Leu Gly Glu Phe Gly Ile Arg Val Ser Ala Val Ala Pro Gly Val 
        195                 200                 205             


Ile Glu Gly Asp Ala Val Arg Arg Arg Ser Ala Ala Ser Asp Arg His 
    210                 215                 220                 


Ala Ala Tyr Met Ala Asp Ile Lys Arg His Val Pro Leu Arg Arg Trp 
225                 230                 235                 240 


Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp Asn 
                245                 250                 255     


Pro Thr Val Thr Gly Thr Val Leu Glu Val Asp Gly Gly Gly Leu Pro 
            260                 265                 270         


Ala Arg Val Val Pro Pro Ala Gly Arg Thr Ala Gly Ala Ser Thr Thr 
        275                 280                 285             


Ala Ala Ser Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300         


<210>  390
<211>  912
<212>  DNA
<213>  Streptomyces griseus

<400>  390
gtgtctgagc agtcatcaac agcgttgccg cgcacgagtg ttcgcggcac cgccctggtc       60

accggcggca gccggggact cggcgccgcc atcgcccgaa agctggccgc cgtcggctgg      120

cacaccgtga tctgcgggcg cgacccggag agcctggacg ccggggtgaa ggcggcggcc      180

gaggacgggc tcgtcctgca cgccgtgcgg gcggacgtca ccgacgagcg gtcggtggcc      240

gccctcttcg agcggctggc cgaggacgcc ccgccgctcg ggctctgcgt caacaacgcg      300

gggaacaact tctcccgccg cctggtgagc gtcaaggaac ggagcgacgg cccgccgctg      360

ctctccccac acccgctgga ggacttcgag cgggtggtga cgtccctgct caccggcacc      420

ttcctcgtcg gccgccacgc ggcgcaggcg atgctgaccg ccggcacgcc cggggcgatc      480

gtcaacatct cctccacggt ccggcacggc gcgtacgggc agtcggcgta ctgcgcggcc      540

aagtccgggg tggaggcgct gacccgcacc tgggcgaccg agctgggcga gtacggcatc      600

cgggtcagcg cggtggcgcc cggagtcatt gacggcgagg cgctgcgccg ccgttcggcg      660

gcgaacgagc ggcacgcggc ctatatgacc gacctccggc gccatgtgcc gctgcgccgc      720

tggtgcgacg agagggacgt ggccgaggcg gtcgccttcg ccgccgacaa cccctcggtg      780

accggcaccg tgctggaggt cgacgcgggc ggactgcccg cccgcgtcct gcccccggcc      840

gaccggacca ccgcaccacg tacgacagcc gcgacggcgg acctccccga gaaagcggag      900

aaaacagcat ga                                                          912


<210>  391
<211>  303
<212>  PRT
<213>  Streptomyces griseus

<400>  391

Met Ser Glu Gln Ser Ser Thr Ala Leu Pro Arg Thr Ser Val Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Asp Ala Gly Val Lys Ala Ala Ala Glu Asp Gly Leu 
    50                  55                  60                  


Val Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Arg Ser Asp Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Thr Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Asn Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Asp Leu Arg Arg His Val Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Pro Ala Asp Arg Thr Thr Ala Pro Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  392
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant6 of nonO polypeptide

<400>  392

Met Ser Glu Gln Ser Ser Thr Ala Leu Pro Arg Thr Ser Val Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Ser Leu Asp Ala Gly Val Lys Ala Ala Ala Glu Asp Gly Val 
    50                  55                  60                  


Val Leu His Ala Ile Arg Ala Asp Val Ser Asp Glu Arg Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Val Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Leu Ser Val Lys 
            100                 105                 110         


Glu Arg Ser Glu Gly Pro Pro Leu Val Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Tyr Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Trp Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Thr Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Gly Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Ser Trp Ala 
            180                 185                 190         


Thr Glu Met Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Asn Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Asp Leu Arg Arg His Val Pro Leu Lys Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Ile Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Pro Ala Asp Arg Thr Thr Gly Pro Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  393
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant7 of nonO polypeptide

<400>  393

Met Ser Glu Gln Ser Ser Thr Ala Leu Pro Arg Thr Ser Val Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Asp Ala Gly Leu Lys Ala Ala Ala Glu Asp Gly Leu 
    50                  55                  60                  


Val Leu His Ala Ile Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Lys Lys Val Val Ser Val Lys 
            100                 105                 110         


Asp Arg Ser Asp Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Asp Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Thr Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Phe Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Arg Arg Lys Ser Gly Ala Asn Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Glu Leu Lys Arg His Ile Pro Leu Lys Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Met Pro Pro Ala Asp Arg Thr Ser Ala Pro Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  394
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant8 of nonO polypeptide

<400>  394

Met Ser Glu Gln Ser Ser Thr Ala Leu Pro Arg Thr Ser Val Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Asp Ala Gly Val Lys Ala Ala Ala Glu Glu Gly Val 
    50                  55                  60                  


Val Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Lys Leu Ala Glu Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Arg Ser Asp Gly Pro Pro Val Leu Ser Pro His Pro Ile Glu Asp 
        115                 120                 125             


Trp Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Val Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Ile Thr Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Ala Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Met Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Gln Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Val Thr Asp Val Arg Lys His Ile Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Ser Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Leu Ile Pro Pro Ala Asp Arg Ser Thr Ala Pro Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Glu Val Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  395
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant9 of nonO polypeptide

<400>  395

Met Ser Glu Asn Ser Ser Thr Ala Leu Pro Arg Thr Thr Val Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Asp Ala Gly Leu Lys Ala Ala Ala Glu Asp Gly Leu 
    50                  55                  60                  


Val Leu His Gly Val Arg Ala Asp Val Thr Asp Glu Arg Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Gly Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Trp Ser Arg Arg Leu Leu Ser Leu Lys 
            100                 105                 110         


Glu Arg Ser Asp Gly Pro Pro Leu Leu Ser Pro His Pro Val Asp Glu 
        115                 120                 125             


Trp Asp Arg Met Val Thr Ser Leu Leu Thr Gly Thr Tyr Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Thr Gly Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Ala Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Lys Ser Trp Ala 
            180                 185                 190         


Thr Glu Leu Ala Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Asp Ala Leu Arg Arg Arg Ser Ala Ala Asn Glu Arg 
    210                 215                 220                 


His Ala Ala Phe Met Thr Asp Leu Lys Arg His Met Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Glu Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Ile Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Gly Arg Val Leu Pro Pro Gly Asp Arg Thr Thr Ala Pro Lys Thr 
        275                 280                 285             


Thr Ala Gly Thr Ala Glu Leu Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  396
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant10 of nonO polypeptide

<400>  396

Met Ser Glu Gln Thr Ser Thr Ala Leu Pro Arg Thr Thr Val Arg Gly 
1               5                   10                  15      


Ser Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg Lys Leu Ala Ala Met Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Ser Leu Asp Ala Ala Ile Lys Ala Ala Ala Glu Asp Gly Leu 
    50                  55                  60                  


Val Leu His Ala Val Arg Ala Asp Val Thr Asp Asp Arg Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Ile Val Ser Leu Lys 
            100                 105                 110         


Glu Arg Ser Asp Gly Pro Pro Leu Leu Ser Pro His Pro Ile Glu Asp 
        115                 120                 125             


Trp Glu Arg Ile Val Thr Ser Leu Leu Thr Gly Thr Phe Val Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Thr Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Gly Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Ala Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Val Arg Lys Arg Ser Ala Ala Asn Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Asp Met Arg Lys His Ile Pro Leu Arg Lys 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Ile Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Val 
            260                 265                 270         


Pro Gly Arg Ile Ile Pro Pro Ala Glu Arg Thr Ser Ala Pro Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Glu Leu Pro Glu Lys Ala Glu Lys Thr Ala 
    290                 295                 300             


<210>  397
<211>  915
<212>  DNA
<213>  Streptomyces sp. SolWspMP

<400>  397
gtgtctgatc agtcgtcaca tgcccttccc tacccctccg gtcgcggcac cgccctggtc       60

accggcggca gccggggcct cggcgcggcc atcgcccgcc atctcgccgc cgtcggctgg      120

cacaccgtga tctgcggacg cgacacggag agcctggacg cggccgtgaa ggcggcggcc      180

gacgacgggc tggcgctcca cgccgtccgg gcggacgtca ccgacgaggg gtcggtggcg      240

gccctgttcg agcggctggc cgaggacgcc ccgccgctcg ggctctgcgt gaacaacgcg      300

ggcaacaact tctcccgccg cctggtgagc gtcaaggagc agccgggcgg gccgccgctg      360

ctctccccgc atccgctgga ggacttccag cgggtggtgt cctccctgct caccggcacc      420

ttcctggtcg gccgccacgc ggcgcaggcg atgctggccg ccgggacgcc cggggccatc      480

gtcaacatct cctccaccgt ccgccacggc gcgtacgggc agtcggcgta ctgcgccgcc      540

aagtccgggg tggaggcgct cacccgcacc tgggcggtgg agctgggcga gtacggcatc      600

cgggtgagcg cggtggcgcc cggggtcatc gacggcgagg cgctgcgccg ccggtcggcg      660

gcgagcgagc ggcacgccgc gtacatgacc gacctgcgac gccatgtgcc gctgcgccgc      720

tggtgcgacg agagcgatgt ggcgcaggcg gtcgccttcg ccgccgacaa cccctcggtg      780

accggcaccg tgctggaggt cgacgcgggc ggactgcccg cccgtgtcct gccccgggac      840

gacgaccgga ccccccgagc ccgtacgaca gccgcgagcg cggacctccc gaagaaagcg      900

gagaacacag catga                                                       915


<210>  398
<211>  304
<212>  PRT
<213>  Streptomyces sp. SolWspMP

<400>  398

Val Ser Asp Gln Ser Ser His Ala Leu Pro Tyr Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu 
    50                  55                  60                  


Ala Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Gly Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Gln Pro Gly Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Gln Arg Val Val Ser Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Val Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Asp Leu Arg Arg His Val Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Ser Asp Val Ala Gln Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Arg Asp Asp Asp Arg Thr Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Ala Asp Leu Pro Lys Lys Ala Glu Asn Thr Ala 
    290                 295                 300                 


<210>  399
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant11 of nonO polypeptide

<400>  399

Val Ser Asp Gln Ser Ser His Ala Met Pro Tyr Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Glu Ser Leu Glu Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu 
    50                  55                  60                  


Ala Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Gly Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Ile Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Gln Pro Gly Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Gln Arg Val Val Ser Ser Leu Leu Thr Gly Thr Tyr Val Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Leu Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Val Glu Leu Ala Glu Phe Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Leu Ile Asp Gly Glu Ala Met Arg Lys Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Leu Thr Asp Leu Arg Lys His Leu Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Ser Asp Val Ala Gln Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Arg Asp Glu Asp Arg Thr Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Gly Asp Leu Pro Lys Lys Ala Glu Asn Thr Ala 
    290                 295                 300                 


<210>  400
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant12 of nonO polypeptide

<400>  400

Val Ser Asp Gln Ser Ser His Ala Leu Pro Tyr Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Asp Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu 
    50                  55                  60                  


Ala Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Gly Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Tyr Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Gln Pro Gly Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Glu 
        115                 120                 125             


Phe Gln Arg Met Val Ser Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Ile Arg His Gly Ala Tyr Ala Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Ser Trp Ala 
            180                 185                 190         


Val Glu Leu Ala Glu Phe Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Lys 
    210                 215                 220                 


His Ala Ala Tyr Met Thr Asp Val Arg Lys His Ile Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Ser Asp Val Ala Gln Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Asp Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Arg Asp Asp Glu Arg Ser Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Ala Asp Leu Pro Lys Lys Ala Glu Asn Thr Ala 
    290                 295                 300                 


<210>  401
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant13 of nonO polypeptide

<400>  401

Val Ser Asp Gln Ser Thr His Ala Val Pro Tyr Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Lys His Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu 
    50                  55                  60                  


Ala Ile His Gly Ile Arg Ala Asp Val Thr Asp Glu Ala Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Lys Leu Ala Glu Asp Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Arg 
            100                 105                 110         


Glu Gln Pro Gly Gly Pro Pro Leu Leu Ser Pro His Pro Leu Asp Asp 
        115                 120                 125             


Phe Gln Lys Val Val Ser Ser Leu Leu Thr Gly Thr Trp Leu Val Gly 
    130                 135                 140                 


Lys His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Val Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Ala Leu Lys Arg Arg Ser Ala Ala Thr Glu Arg 
    210                 215                 220                 


His Ala Ala Phe Met Thr Asp Leu Arg Arg His Val Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Ser Asp Val Ala Gln Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Met Ser Gly Ser Leu Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Met Pro Arg Asp Asp Asp Arg Thr Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Ala Asp Leu Pro Lys Lys Ala Asp Asn Thr Ala 
    290                 295                 300                 


<210>  402
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant14 of nonO polypeptide

<400>  402

Val Ser Asp Asn Ser Ser His Ala Leu Pro Tyr Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Lys His Leu Ala Ala Val Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Glu Ser Leu Glu Ala Ala Val Lys Ala Ala Ala Asp Glu Ala Leu 
    50                  55                  60                  


Ala Val His Ala Val Arg Gly Asp Val Thr Asp Glu Gly Ser Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Glu Asp Ala Pro Pro Leu Gly Val Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Gln Pro Ala Gly Pro Pro Leu Met Thr Pro His Pro Leu Asp Glu 
        115                 120                 125             


Trp Gln Arg Val Val Ser Ser Leu Leu Thr Gly Thr Phe Met Val Gly 
    130                 135                 140                 


Lys His Ala Ala Gln Gly Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg His Ala Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Asp Ala Leu Thr Arg Ser Trp Ala 
            180                 185                 190         


Val Glu Leu Ala Glu Tyr Gly Ile Arg Val Thr Ala Val Ala Pro Gly 
        195                 200                 205             


Val Ile Asp Gly Glu Gly Leu Arg Lys Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Val Thr Asp Met Arg Arg His Val Pro Met Lys Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Ser Asp Val Ala Gln Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Leu Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Val 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Arg Asp Asp Asp Arg Thr Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Ala Asp Leu Pro Arg Lys Ala Glu Asn Thr Ala 
    290                 295                 300                 


<210>  403
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant15 of nonO polypeptide

<400>  403

Val Ser Asp Gln Ser Ser His Ala Leu Pro Phe Pro Ser Gly Arg Gly 
1               5                   10                  15      


Thr Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ala Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Val Gly Tyr His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Thr Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Leu 
    50                  55                  60                  


Ala Ile His Ala Met Arg Ala Asp Val Thr Asp Glu Ala Thr Val Ala 
65                  70                  75                  80  


Ala Leu Phe Glu Arg Leu Ala Asp Asp Ala Pro Pro Leu Gly Val Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Gln Phe Ser Arg Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Gln Pro Gly Gly Pro Pro Ile Ile Ser Pro His Pro Ile Glu Glu 
        115                 120                 125             


Phe Gln Arg Val Val Ser Ser Leu Leu Thr Gly Thr Phe Leu Val Ala 
    130                 135                 140                 


Lys His Ala Ala Gln Ala Met Met Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Leu Arg His Gly Ala Tyr Gly Asn Thr Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Ile Glu Leu Gly Glu Tyr Gly Ile Arg Val Thr Ala Val Ala Pro Gly 
        195                 200                 205             


Leu Ile Asp Gly Asp Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Gly Tyr Met Thr Glu Met Arg Arg His Val Pro Leu Arg Arg 
225                 230                 235                 240 


Phe Cys Asp Glu Ser Asp Val Ala Gln Gly Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Leu Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Leu Leu Pro Arg Asp Asp Asp Arg Thr Pro Arg Ala Arg 
        275                 280                 285             


Thr Thr Ala Ala Ser Ala Asp Leu Pro Lys Lys Ala Glu Asn Thr Ala 
    290                 295                 300                 


<210>  404
<211>  888
<212>  DNA
<213>  Streptomyces sp. W007

<400>  404
atgccgcgca ccggcgttcg cggcaccgcc ctcgtcaccg gcggcagccg gggcctcggc       60

gccgccatcg cccgaaagct ggccgccgtc ggctggcaca ccgtgatctg cgggcgcgac      120

ccggagagcc tggacgacgc ggtgaaggcg gcggccgacg acgggctcgt cctgcacgcc      180

gtgcgggcgg acgtcaccga cgagcggtcg gtggccgccc tcttcgagcg gctggccgag      240

gacgccccgc cgctcgggct ctgcgtcaac aacgcgggga acaacttctc ccgccgcctg      300

gtgagcgtca gggaacggag cgacggcccg ccgctgctct ccccgcaccc gctggaggac      360

ttcgagcggg tggtgacgtc cctgctcacc ggcaccttcc tcgtcggccg ccacgcggct      420

caggcgatgc tgaccgccgg cacgcccggg gcgatcgtca acatctcctc cacggtccgg      480

cacggcgcgt acgggcagtc ggcgtactgc gcggccaagt ccggggtgga ggcgctgacc      540

cgcacctggg cgaccgagct gggcgagtac ggcatccggg tcagcgcggt ggcgcccgga      600

gtcatcgacg gcgaggcgct gcgccgccgt tcggcggcga acgagcggca cgcggcctat      660

atgaccgacc tccggcgcca tgtgccgctg cgccgctggt gcgacgagag ggacgtggcc      720

gaggcggtcg ccttcgccgc cgacaacccc tccgtgaccg gcaccgtgct ggaggtcgac      780

gcgggcggac tgcccgcccg cgtcctgccc ccggccgacc ggaccaccac accacgtacg      840

acagccgcaa cggcggacct ccccgagaaa gcggagaaaa cagcatga                   888


<210>  405
<211>  295
<212>  PRT
<213>  Streptomyces sp. W007

<400>  405

Met Pro Arg Thr Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Lys Leu Ala Ala Val Gly Trp 
            20                  25                  30          


His Thr Val Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Val 
        35                  40                  45              


Lys Ala Ala Ala Asp Asp Gly Leu Val Leu His Ala Val Arg Ala Asp 
    50                  55                  60                  


Val Thr Asp Glu Arg Ser Val Ala Ala Leu Phe Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Asp Ala Pro Pro Leu Gly Leu Cys Val Asn Asn Ala Gly Asn Asn Phe 
                85                  90                  95      


Ser Arg Arg Leu Val Ser Val Arg Glu Arg Ser Asp Gly Pro Pro Leu 
            100                 105                 110         


Leu Ser Pro His Pro Leu Glu Asp Phe Glu Arg Val Val Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Phe Leu Val Gly Arg His Ala Ala Gln Ala Met Leu 
    130                 135                 140                 


Thr Ala Gly Thr Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Val Arg 
145                 150                 155                 160 


His Gly Ala Tyr Gly Gln Ser Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Ala Leu Thr Arg Thr Trp Ala Thr Glu Leu Gly Glu Tyr Gly Ile 
            180                 185                 190         


Arg Val Ser Ala Val Ala Pro Gly Val Ile Asp Gly Glu Ala Leu Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Glu Arg His Ala Ala Tyr Met Thr Asp Leu 
    210                 215                 220                 


Arg Arg His Val Pro Leu Arg Arg Trp Cys Asp Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Ala Val Ala Phe Ala Ala Asp Asn Pro Ser Val Thr Gly Thr Val 
                245                 250                 255     


Leu Glu Val Asp Ala Gly Gly Leu Pro Ala Arg Val Leu Pro Pro Ala 
            260                 265                 270         


Asp Arg Thr Thr Thr Pro Arg Thr Thr Ala Ala Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  406
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant16 of nonO polypeptide

<400>  406

Met Pro Arg Thr Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Arg Leu Ala Ala Val Gly Trp 
            20                  25                  30          


His Thr Val Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Val 
        35                  40                  45              


Lys Ala Ala Ala Asp Asp Gly Leu Val Leu His Ala Val Arg Ala Asp 
    50                  55                  60                  


Val Thr Asp Glu Arg Ser Val Ala Ala Leu Phe Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Asp Ala Pro Pro Leu Gly Leu Cys Val Asn Asn Ala Gly Asn Asn Phe 
                85                  90                  95      


Ser Arg Arg Val Val Ser Val Arg Glu Arg Ser Asp Gly Pro Pro Leu 
            100                 105                 110         


Leu Ser Pro His Pro Leu Glu Asp Phe Glu Arg Val Leu Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Tyr Leu Val Gly Arg His Ala Ala Gln Ala Met Ile 
    130                 135                 140                 


Thr Ala Gly Ser Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Val Arg 
145                 150                 155                 160 


His Gly Ala Tyr Gly Gln Thr Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Ala Leu Thr Arg Thr Trp Ala Thr Glu Leu Gly Glu Tyr Gly Ile 
            180                 185                 190         


Arg Val Ser Ala Val Ala Pro Gly Val Ile Glu Gly Glu Ala Leu Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Glu Arg His Ala Ala Tyr Met Thr Asp Leu 
    210                 215                 220                 


Arg Lys His Leu Pro Val Arg Arg Trp Cys Asp Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Gly Val Ala Phe Ala Ala Asp Asn Pro Ser Leu Thr Gly Thr Val 
                245                 250                 255     


Leu Glu Val Asp Ala Gly Gly Leu Pro Ala Lys Val Leu Pro Pro Gly 
            260                 265                 270         


Asp Arg Thr Thr Thr Pro Arg Thr Thr Ala Ala Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  407
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant17 of nonO polypeptide

<400>  407

Met Pro Arg Thr Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Lys Leu Ala Ala Val Gly Trp 
            20                  25                  30          


His Thr Ile Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Val 
        35                  40                  45              


Lys Ala Ala Ala Asp Asp Gly Val Val Val His Ala Val Arg Ala Asp 
    50                  55                  60                  


Val Thr Asp Glu Arg Ser Val Ala Ala Leu Phe Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Asp Ala Pro Pro Leu Gly Leu Cys Val Asn Asn Ala Gly Asn Asn Phe 
                85                  90                  95      


Ser Arg Arg Leu Leu Ser Val Lys Glu Arg Ser Asp Gly Pro Pro Leu 
            100                 105                 110         


Leu Ser Pro His Pro Leu Glu Asp Phe Asp Arg Val Val Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Phe Leu Val Gly Arg His Ala Ala Gln Ala Met Leu 
    130                 135                 140                 


Thr Ala Gly Thr Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Leu Arg 
145                 150                 155                 160 


His Gly Ala Tyr Gly Asn Ser Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Ala Leu Thr Arg Thr Trp Ala Thr Glu Leu Ala Glu Tyr Gly Ile 
            180                 185                 190         


Arg Val Ser Ala Val Ala Pro Gly Val Ile Asp Gly Glu Ala Leu Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Glu Arg His Ala Ala Tyr Met Thr Asp Leu 
    210                 215                 220                 


Arg Arg His Val Pro Met Arg Arg Phe Cys Asp Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Ala Val Ala Trp Ala Ala Asp Asn Pro Ser Val Thr Gly Thr Val 
                245                 250                 255     


Leu Asp Val Asp Ala Gly Gly Leu Pro Gly Arg Val Met Pro Pro Ala 
            260                 265                 270         


Asp Arg Thr Thr Thr Pro Arg Thr Thr Ala Ala Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  408
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant18 of nonO polypeptide

<400>  408

Met Pro Arg Thr Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Lys Leu Ala Gly Val Gly Trp 
            20                  25                  30          


His Thr Val Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Val 
        35                  40                  45              


Lys Ala Ala Ala Asp Asp Gly Leu Val Val His Ala Val Arg Ala Asp 
    50                  55                  60                  


Val Ser Asp Glu Lys Ser Val Ala Ala Leu Phe Glu Lys Leu Ala Glu 
65                  70                  75                  80  


Asp Ala Pro Pro Leu Gly Leu Cys Val Asn Asn Ala Gly Asn Asn Phe 
                85                  90                  95      


Ser Arg Arg Leu Val Ser Leu Arg Glu Arg Ser Asp Gly Pro Pro Leu 
            100                 105                 110         


Leu Thr Pro His Pro Leu Glu Asp Trp Glu Arg Leu Val Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Phe Leu Val Ala Arg His Ala Gly Gln Ala Met Leu 
    130                 135                 140                 


Thr Gly Gly Thr Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Val Arg 
145                 150                 155                 160 


His Gly Ala Tyr Gly Gln Ser Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Ala Leu Thr Arg Thr Trp Ala Thr Glu Leu Gly Glu Tyr Gly Ile 
            180                 185                 190         


Arg Val Ser Ala Val Ala Pro Gly Val Ile Asp Gly Glu Ala Val Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Asp Lys His Ala Ala Tyr Ile Thr Asp Ile 
    210                 215                 220                 


Arg Arg His Val Pro Leu Arg Arg Trp Cys Glu Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Ala Val Ala Phe Ala Ala Asp Asn Pro Ser Ile Thr Gly Thr Val 
                245                 250                 255     


Leu Glu Val Asp Ala Gly Gly Leu Pro Gly Arg Val Leu Pro Pro Ala 
            260                 265                 270         


Asp Arg Thr Thr Ser Pro Arg Thr Thr Ala Ala Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  409
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant19 of nonO polypeptide

<400>  409

Met Pro Arg Ser Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Lys Leu Ala Ala Val Gly Trp 
            20                  25                  30          


His Thr Ile Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Leu 
        35                  40                  45              


Lys Ala Ala Ala Asp Glu Gly Leu Val Val His Gly Val Arg Ala Asp 
    50                  55                  60                  


Val Thr Asp Glu Arg Ser Val Ala Ala Leu Phe Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Glu Ala Pro Pro Leu Gly Ile Cys Val Asn Asn Ala Gly Asn Asn Phe 
                85                  90                  95      


Ser Arg Arg Leu Leu Ser Val Lys Glu Arg Ser Asp Gly Pro Pro Leu 
            100                 105                 110         


Ile Ser Pro His Pro Leu Glu Asp Phe Glu Arg Leu Val Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Phe Leu Val Ala Arg His Ala Ala Gln Ala Met Leu 
    130                 135                 140                 


Thr Ala Gly Thr Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Val Arg 
145                 150                 155                 160 


His Gly Ala Tyr Gly Gln Ser Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Gly Leu Thr Lys Thr Trp Ala Thr Glu Leu Ala Asp Tyr Gly Ile 
            180                 185                 190         


Arg Val Ser Ala Val Ala Pro Gly Val Ile Glu Gly Glu Gly Leu Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Asp Arg His Gly Ala Phe Met Thr Glu Met 
    210                 215                 220                 


Arg Arg His Val Pro Leu Arg Lys Trp Cys Asp Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Ala Val Ala Tyr Ala Ala Asp Asn Pro Ser Val Ser Gly Thr Val 
                245                 250                 255     


Leu Glu Val Asp Ala Gly Gly Leu Pro Ala Lys Val Leu Pro Pro Ala 
            260                 265                 270         


Asp Arg Thr Thr Thr Pro Lys Thr Ser Ala Ala Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  410
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant20 of nonO polypeptide

<400>  410

Met Pro Arg Thr Gly Val Arg Gly Thr Ala Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Arg Gly Leu Gly Ala Ala Ile Ala Arg Arg Leu Ala Ala Val Gly Trp 
            20                  25                  30          


His Thr Ile Ile Cys Gly Arg Asp Pro Glu Ser Leu Asp Asp Ala Val 
        35                  40                  45              


Lys Ala Ala Ala Asp Asp Gly Leu Val Leu His Ala Val Arg Gly Asp 
    50                  55                  60                  


Val Thr Asp Glu Arg Ser Val Ala Ala Leu Phe Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Glu Ala Pro Pro Leu Gly Leu Cys Val Asn Asn Ala Gly Asn Asn Tyr 
                85                  90                  95      


Ser Arg Arg Leu Val Ser Val Arg Asp Arg Ser Asp Ala Pro Pro Ile 
            100                 105                 110         


Ile Ser Pro His Pro Leu Glu Asp Phe Glu Arg Met Met Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Thr Phe Leu Val Gly Arg His Ala Ala Gln Ala Met Leu 
    130                 135                 140                 


Thr Ala Gly Thr Pro Gly Ala Ile Val Asn Ile Ser Ser Thr Val Arg 
145                 150                 155                 160 


His Gly Gly Tyr Ala Gln Ser Ala Tyr Cys Ala Ala Lys Ser Gly Val 
                165                 170                 175     


Glu Ala Leu Thr Lys Thr Trp Ala Thr Glu Leu Ala Glu Tyr Gly Ile 
            180                 185                 190         


Arg Val Thr Ala Val Ala Pro Gly Leu Ile Asp Gly Asp Ala Val Arg 
        195                 200                 205             


Arg Arg Ser Ala Ala Asn Glu Lys His Ala Gly Phe Val Thr Asp Leu 
    210                 215                 220                 


Arg Arg His Leu Pro Leu Arg Arg Trp Cys Asp Glu Arg Asp Val Ala 
225                 230                 235                 240 


Glu Ala Val Ala Phe Ala Ala Asp Asn Pro Ser Ile Ser Gly Thr Val 
                245                 250                 255     


Leu Glu Val Asp Ala Gly Gly Ile Pro Ala Arg Val Leu Pro Pro Gly 
            260                 265                 270         


Asp Arg Thr Ser Thr Pro Arg Thr Thr Ala Gly Thr Ala Asp Leu Pro 
        275                 280                 285             


Glu Lys Ala Glu Lys Thr Ala 
    290                 295 


<210>  411
<211>  912
<212>  DNA
<213>  Streptomyces californicus

<400>  411
gtgtctgatc aaccgtcatc atctctacga ggcagcgccg ttcggggtgc cgccctggtc       60

accgggggaa gccgggggct cggttcggcc atcgcccgcc atctcgccgg cgctggatgg      120

cacaccgtga tctgcgggcg tgacccggac agcctggacg ccgccgtgaa ggccgcggcg      180

gacgacggga tcgccctgca cgccgtacgg gcggacgtca ccgacgagga gtcggtggcc      240

gggctcttcg accacttggc cgtggaggcc ccgccgctgg gcctctgcgt caacaacgcg      300

ggcaacaact tctcccgccg cctggtgagc gtcagggagc ggcccgacgg accgccgctg      360

ctctccccgc atccgctcga ggacttcgag cgggtggtga cctcgctgct caccggcacc      420

ttcctggtcg gccggcacgc cgcgcaggcg atgctggccg ccggcacgcc cggcgcgatc      480

gtcaacatct cctccaccgt gcgccggggc gcgtacggcc agtcggcgta ctgcgcggcc      540

aagtccgggg tggaggcgct cacccgcacc tgggcgaccg agctgggcga gtacggcatc      600

cgggtcagcg cggtggcccc cggagtcatc gacggcgagg cgctgcgccg ccgttcggcg      660

gcgaacgagc ggcacgcggc ctatatgacc gacctccggc gccatgtgcc gctgcgccgc      720

tggtgcgacg agagggacgt ggccgaggcg gtcgccttcg ccgccgacaa cccctccgtg      780

accggcaccg tgctggaggt cgacgcgggc ggactgcccg cccgcgtcct gcccccggcc      840

gaccggacca ccacaccacg tacgacagcc gcaacggcgg acctccccga gaaagcggag      900

aaaacagcat ga                                                          912


<210>  412
<211>  303
<212>  PRT
<213>  Streptomyces californicus

<400>  412

Met Ser Asp Gln Pro Ser Ser Ser Leu Arg Gly Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ser Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Ile 
    50                  55                  60                  


Ala Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Asp His Leu Ala Val Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Arg 
            100                 105                 110         


Glu Arg Pro Asp Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg Arg Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Val Asp Gly Glu Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Ala Asp Leu Arg Arg His Val Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Pro Ala Gly Pro Asp Thr Glu Thr Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


<210>  413
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant21 of nonO polypeptide

<400>  413

Met Ser Asp Gln Pro Ser Thr Ser Ile Lys Ala Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ser Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Glu Asp Gly Ile 
    50                  55                  60                  


Ala Leu His Ala Val Arg Ala Asp Val Thr Asp Glu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Asp His Leu Ala Val Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Arg 
            100                 105                 110         


Glu Arg Pro Asp Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Glu 
        115                 120                 125             


Phe Glu Arg Val Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Ala 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Leu Arg Arg Gly Ala Tyr Ala Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Val Asp Gly Asp Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Gly Tyr Met Ala Asp Val Arg Arg His Val Pro Met Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Asp Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Ile Leu Pro Pro Ala Gly Pro Asp Thr Glu Thr Arg Ser 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


<210>  414
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant22 of nonO polypeptide

<400>  414

Met Ser Asp Gln Pro Ser Ser Ser Leu Arg Gly Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ser Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Ala Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Thr Ile Asp Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Ile 
    50                  55                  60                  


Ala Val His Ala Val Arg Ala Asp Val Thr Asp Glu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Asp His Leu Ala Leu Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Ile Ser Val Arg 
            100                 105                 110         


Glu Arg Pro Asp Gly Pro Pro Leu Leu Ser Pro His Pro Val Glu Asp 
        115                 120                 125             


Phe Glu Arg Val Ile Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Gly Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg Arg Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Gly Leu Thr Arg Ser Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Met Val Asp Gly Asp Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Ala Asp Leu Arg Arg His Val Pro Met Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Gly Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Ser Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Pro Ala Gly Pro Asp Thr Glu Thr Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


<210>  415
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant23 of nonO polypeptide

<400>  415

Met Ser Glu Gln Pro Thr Thr Ser Leu Arg Gly Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Thr Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Glu Ala Ala Val Lys Ala Ala Ala Asp Asp Gly Ile 
    50                  55                  60                  


Ala Ile His Ala Leu Arg Ala Asp Val Thr Asp Asp Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Asp His Leu Ala Val Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Lys Arg Leu Val Ser Val Lys 
            100                 105                 110         


Glu Arg Pro Asp Gly Pro Pro Leu Leu Ser Pro His Pro Leu Glu Glu 
        115                 120                 125             


Tyr Asp Arg Met Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg Lys Gly Ala Tyr Gly Gln Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Ala Leu Thr Lys Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Ala Pro Gly 
        195                 200                 205             


Val Val Asp Gly Asp Ala Leu Arg Arg Arg Ser Ala Ala Ser Glu Arg 
    210                 215                 220                 


His Ala Ala Tyr Leu Ala Asp Leu Arg Arg His Leu Pro Val Arg Arg 
225                 230                 235                 240 


Trp Cys Asp Glu Arg Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Ser Val Thr Gly Thr Val Leu Glu Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Leu Leu Pro Pro Ala Gly Pro Asp Thr Glu Thr Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


<210>  416
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant24 of nonO polypeptide

<400>  416

Met Ser Asp Gln Pro Ser Ser Ser Leu Arg Gly Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ser Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Glu Ser Leu Asp Ala Ala Val Lys Ala Ala Ala Glu Asp Gly Ile 
    50                  55                  60                  


Gly Leu His Ala Leu Arg Ala Asp Val Thr Asp Glu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Asp His Leu Ala Val Asp Gly Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Ser Arg Arg Leu Val Ser Val Arg 
            100                 105                 110         


Asp Arg Pro Asp Gly Pro Pro Leu Leu Ser Pro His Pro Val Asp Asp 
        115                 120                 125             


Phe Glu Arg Ile Met Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Gly 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg Arg Gly Ala Tyr Gly Asn Ser Gly 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Gly Leu Thr Lys Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Ala Asp Tyr Gly Ile Arg Val Thr Ala Val Ala Pro Gly 
        195                 200                 205             


Met Val Asp Gly Glu Ala Leu Arg Arg Lys Ser Ala Ala Ser Glu Lys 
    210                 215                 220                 


His Ala Gly Tyr Met Ala Asp Ile Lys Arg His Leu Pro Leu Arg Arg 
225                 230                 235                 240 


Trp Cys Glu Glu Arg Asp Val Ala Glu Ala Val Ala Trp Ala Ala Asp 
                245                 250                 255     


Gln Pro Ser Val Thr Gly Thr Val Leu Asp Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Val Leu Pro Pro Ala Gly Pro Glu Thr Glu Thr Arg Ser 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


<210>  417
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant25 of nonO polypeptide

<400>  417

Met Thr Asp Gln Pro Ser Ser Ser Leu Arg Gly Ser Ala Val Arg Gly 
1               5                   10                  15      


Ala Ala Leu Val Thr Gly Gly Ser Arg Gly Leu Gly Ser Ala Ile Ala 
            20                  25                  30          


Arg His Leu Ala Gly Ala Gly Trp His Thr Val Ile Cys Gly Arg Asp 
        35                  40                  45              


Pro Asp Thr Leu Asp Ala Ala Leu Lys Ala Ala Ala Asp Asp Gly Ile 
    50                  55                  60                  


Ala Met His Ala Leu Arg Gly Asp Val Thr Asp Glu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Leu Phe Glu His Leu Ala Val Glu Ala Pro Pro Leu Gly Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Gly Asn Asn Phe Thr Arg Arg Leu Val Thr Val Arg 
            100                 105                 110         


Asp Arg Pro Asp Gly Pro Pro Leu Ile Ser Pro His Pro Leu Glu Asp 
        115                 120                 125             


Phe Asp Arg Met Val Thr Ser Leu Leu Thr Gly Thr Phe Leu Val Ala 
    130                 135                 140                 


Arg His Ala Ala Gln Ala Met Leu Ala Ala Gly Thr Pro Gly Ala Ile 
145                 150                 155                 160 


Val Asn Ile Ser Ser Thr Val Arg Arg Gly Ala Tyr Gly Asn Ser Ala 
                165                 170                 175     


Tyr Cys Ala Ala Lys Ser Gly Val Glu Gly Leu Thr Arg Thr Trp Ala 
            180                 185                 190         


Thr Glu Leu Gly Glu Tyr Gly Ile Arg Val Ser Ala Val Gly Pro Gly 
        195                 200                 205             


Val Val Asp Gly Glu Gly Leu Arg Arg Lys Ser Gly Ala Ser Asp Arg 
    210                 215                 220                 


His Ala Ala Tyr Met Ala Glu Leu Arg Lys His Leu Pro Leu Arg Arg 
225                 230                 235                 240 


Phe Cys Asp Glu Lys Asp Val Ala Glu Ala Val Ala Phe Ala Ala Asp 
                245                 250                 255     


Asn Pro Thr Val Thr Gly Thr Val Leu Asp Val Asp Ala Gly Gly Leu 
            260                 265                 270         


Pro Ala Arg Leu Ile Pro Pro Ala Gly Pro Asp Thr Glu Ser Arg Thr 
        275                 280                 285             


Thr Ala Ala Thr Ala Asp Leu Pro Glu Lys Ala Glu Asn Thr Ala 
    290                 295                 300             


