                               SEQUENCE LISTING

<110> CLUBE, JASPER R.
 
<120> HUMAN TARGETS 

<130> 069496-082995-CIP

<140>
<141>

<150> 14/331,730
<151> 2014-07-15

<160> 134 

<170> PatentIn version 3.5

<210> 1
<211> 692
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 2
<211> 662
<212> PRT
<213> Homo sapiens

<400> 2
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 3
<211> 540
<212> PRT
<213> Homo sapiens

<400> 3
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 4
<211> 692
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 5
<211> 662
<212> PRT
<213> Homo sapiens

<400> 5
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 6
<211> 540
<212> PRT
<213> Homo sapiens

<400> 6
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Val Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 7
<211> 692
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 8
<211> 662
<212> PRT
<213> Homo sapiens

<400> 8
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 9
<211> 540
<212> PRT
<213> Homo sapiens

<400> 9
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Gly Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 10
<211> 692
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 11
<211> 662
<212> PRT
<213> Homo sapiens

<400> 11
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 12
<211> 540
<212> PRT
<213> Homo sapiens

<400> 12
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Val Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Gly Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 13
<211> 692
<212> PRT
<213> Homo sapiens

<400> 13
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Val Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 14
<211> 662
<212> PRT
<213> Homo sapiens

<400> 14
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Val Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 15
<211> 692
<212> PRT
<213> Homo sapiens

<400> 15
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 16
<211> 662
<212> PRT
<213> Homo sapiens

<400> 16
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 17
<211> 540
<212> PRT
<213> Homo sapiens

<400> 17
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Thr Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 18
<211> 692
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Ser Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 19
<211> 662
<212> PRT
<213> Homo sapiens

<400> 19
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Ser Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 20
<211> 540
<212> PRT
<213> Homo sapiens

<400> 20
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Ser Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Val Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 21
<211> 692
<212> PRT
<213> Homo sapiens

<400> 21
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Pro Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 22
<211> 662
<212> PRT
<213> Homo sapiens

<400> 22
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Pro Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 23
<211> 540
<212> PRT
<213> Homo sapiens

<400> 23
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Thr Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe 
    290                 295                 300                 


Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr 
305                 310                 315                 320 


Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser 
                325                 330                 335     


Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly 
            340                 345                 350         


Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val 
        355                 360                 365             


Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val 
    370                 375                 380                 


His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys 
385                 390                 395                 400 


His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val 
                405                 410                 415     


Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln 
            420                 425                 430         


Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys 
        435                 440                 445             


Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro 
    450                 455                 460                 


Ala Pro Pro Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu 
465                 470                 475                 480 


Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr 
                485                 490                 495     


Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr 
            500                 505                 510         


Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg 
        515                 520                 525             


Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
    530                 535                 540 


<210> 24
<211> 692
<212> PRT
<213> Homo sapiens

<400> 24
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Leu Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 25
<211> 662
<212> PRT
<213> Homo sapiens

<400> 25
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Leu 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 26
<211> 692
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Val Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210> 27
<211> 662
<212> PRT
<213> Homo sapiens

<400> 27
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Val Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210> 28
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 28
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 29
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 29
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 30
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 30
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaaggg gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 31
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 31
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaaggg gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 32
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 32
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggtcg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 33
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 33
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccaccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 34
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 34
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcagtgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 35
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 35
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccaccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctccggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 36
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 36
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgctttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 37
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 37
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggtcg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaagacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaaggg gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtgac                           2080


<210> 38
<211> 98
<212> PRT
<213> Homo sapiens

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210> 39
<211> 296
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 39
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ga                                                             296
Ala Lys                                                                   
                                                                          


<210> 40
<211> 25
<212> PRT
<213> Homo sapiens

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 41
<211> 990
<212> DNA
<213> Homo sapiens

<400> 41
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210> 42
<211> 330
<212> PRT
<213> Homo sapiens

<400> 42
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 43
<211> 978
<212> DNA
<213> Homo sapiens

<400> 43
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210> 44
<211> 326
<212> PRT
<213> Homo sapiens

<400> 44
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 45
<211> 296
<212> DNA
<213> Homo sapiens

<400> 45
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaga          296


<210> 46
<211> 98
<212> PRT
<213> Homo sapiens

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210> 47
<211> 296
<212> DNA
<213> Homo sapiens

<400> 47
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaga          296


<210> 48
<211> 98
<212> PRT
<213> Homo sapiens

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210> 49
<211> 321
<212> DNA
<213> Homo sapiens

<400> 49
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210> 50
<211> 107
<212> PRT
<213> Homo sapiens

<400> 50
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 51
<211> 318
<212> DNA
<213> Homo sapiens

<400> 51
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcttggaaag cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210> 52
<211> 106
<212> PRT
<213> Homo sapiens

<400> 52
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210> 53
<211> 365
<212> DNA
<213> Homo sapiens

<400> 53
atggtgttgc agacccaggt cttcatttct ctgttgctct ggatctctgg tgcctacggg       60

gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc      120

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      180

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      240

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      300

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      360

cctcc                                                                  365


<210> 54
<211> 101
<212> PRT
<213> Homo sapiens

<400> 54
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro 
            100     


<210> 55
<211> 654
<212> DNA
<213> Homo sapiens

<400> 55
atggacatga gggtccccgc tcagctcctg gggcttctgc tgctctggct cccagcaggt       60

gccagatgtg ccatccagtt gacccagtct ccatcctccc tgtctgcatc tgtaggagac      120

agagtcacca tcacttgccg ggcaagtcag ggcattagca gtgctttagc ctggtatcag      180

cagaaaccag ggaaagctcc taagctcctg atctatgatg cctccagttt ggaaagtggg      240

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      300

ctgcagcctg aagattttgc aacttattac tgtcaacagt ttaatagtta ccctcagtgc      360

cagatgtgcc atccagttga cccagtctcc atcctccctg tctgcatctg taggagacag      420

agtcaccatc acttgccggg caagtcaggg cattagcagt gctttagcct ggtatcagca      480

gaaaccaggg aaagctccta agctcctgat ctatgatgcc tccagtttgg aaagtggggt      540

cccatcaagg ttcagcggca gtggatctgg gacagatttc actctcacca tcagcagcct      600

gcagcctgaa gattttgcaa cttattactg tcaacagttt aatagttacc ctca            654


<210> 56

<400> 56
000


<210> 57
<211> 39
<212> DNA
<213> Homo sapiens

<400> 57
tgtacacttt tggccagggg accaagctgg agatcaaac                              39


<210> 58
<211> 12
<212> PRT
<213> Homo sapiens

<400> 58
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210> 59
<211> 38
<212> DNA
<213> Homo sapiens

<400> 59
tgtggtattc ggcggaggga ccaagctgac cgtcctag                               38


<210> 60
<211> 12
<212> PRT
<213> Homo sapiens

<400> 60
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10          


<210> 61
<211> 329
<212> PRT
<213> Homo sapiens

<400> 61
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210> 62
<211> 107
<212> PRT
<213> Homo sapiens

<400> 62
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 63
<211> 326
<212> PRT
<213> Homo sapiens

<400> 63
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 64
<211> 105
<212> PRT
<213> Homo sapiens

<400> 64
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210> 65
<211> 326
<212> PRT
<213> Homo sapiens

<400> 65
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 66
<211> 107
<212> PRT
<213> Homo sapiens

<400> 66
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 67
<211> 825
<212> PRT
<213> Homo sapiens

<400> 67
Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210> 68
<211> 2478
<212> DNA
<213> Homo sapiens

<400> 68
atggggtggc tttgctctgg gctcctgttc cctgtgagct gcctggtcct gctgcaggtg       60

gcaagctctg ggaacatgaa ggtcttgcag gagcccacct gcgtctccga ctacatgagc      120

atctctactt gcgagtggaa gatgaatggt cccaccaatt gcagcaccga gctccgcctg      180

ttgtaccagc tggtttttct gctctccgaa gcccacacgt gtatccctga gaacaacgga      240

ggcgcggggt gcgtgtgcca cctgctcatg gatgacgtgg tcagtgcgga taactataca      300

ctggacctgt gggctgggca gcagctgctg tggaagggct ccttcaagcc cagcgagcat      360

gtgaaaccca gggccccagg aaacctgaca gttcacacca atgtctccga cactctgctg      420

ctgacctgga gcaacccgta tccccctgac aattacctgt ataatcatct cacctatgca      480

gtcaacattt ggagtgaaaa cgacccggca gatttcagaa tctataacgt gacctaccta      540

gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg      600

gtgagggcct gggctcagtg ctataacacc acctggagtg agtggagccc cagcaccaag      660

tggcacaact cctacaggga gcccttcgag cagcacctcc tgctgggcgt cagcgtttcc      720

tgcattgtca tcctggccgt ctgcctgttg tgctatgtca gcatcaccaa gattaagaaa      780

gaatggtggg atcagattcc caacccagcc cgcagccgcc tcgtggctat aataatccag      840

gatgctcagg ggtcacagtg ggagaagcgg tcccgaggcc aggaaccagc caagtgccca      900

cactggaaga attgtcttac caagctcttg ccctgttttc tggagcacaa catgaaaagg      960

gatgaagatc ctcacaaggc tgccaaagag atgcctttcc agggctctgg aaaatcagca     1020

tggtgcccag tggagatcag caagacagtc ctctggccag agagcatcag cgtggtgcga     1080

tgtgtggagt tgtttgaggc cccggtggag tgtgaggagg aggaggaggt agaggaagaa     1140

aaagggagct tctgtgcatc gcctgagagc agcagggatg acttccagga gggaagggag     1200

ggcattgtgg cccggctaac agagagcctg ttcctggacc tgctcggaga ggagaatggg     1260

ggcttttgcc agcaggacat gggggagtca tgccttcttc caccttcggg aagtacgagt     1320

gctcacatgc cctgggatga gttcccaagt gcagggccca aggaggcacc tccctggggc     1380

aaggagcagc ctctccacct ggagccaagt cctcctgcca gcccgaccca gagtccagac     1440

aacctgactt gcacagagac gcccctcgtc atcgcaggca accctgctta ccgcagcttc     1500

agcaactccc tgagccagtc accgtgtccc agagagctgg gtccagaccc actgctggcc     1560

agacacctgg aggaagtaga acccgagatg ccctgtgtcc cccagctctc tgagccaacc     1620

actgtgcccc aacctgagcc agaaacctgg gagcagatcc tccgccgaaa tgtcctccag     1680

catggggcag ctgcagcccc cgtctcggcc cccaccagtg gctatcagga gtttgtacat     1740

gcggtggagc agggtggcac ccaggccagt gcggtggtgg gcttgggtcc cccaggagag     1800

gctggttaca aggccttctc aagcctgctt gccagcagtg ctgtgtcccc agagaaatgt     1860

gggtttgggg ctagcagtgg ggaagagggg tataagcctt tccaagacct cattcctggc     1920

tgccctgggg accctgcccc agtccctgtc cccttgttca cctttggact ggacagggag     1980

ccacctcgca gtccgcagag ctcacatctc ccaagcagct ccccagagca cctgggtctg     2040

gagccggggg aaaaggtaga ggacatgcca aagcccccac ttccccagga gcaggccaca     2100

gacccccttg tggacagcct gggcagtggc attgtctact cagcccttac ctgccacctg     2160

tgcggccacc tgaaacagtg tcatggccag gaggatggtg gccagacccc tgtcatggcc     2220

agtccttgct gtggctgctg ctgtggagac aggtcctcgc cccctacaac ccccctgagg     2280

gccccagacc cctctccagg tggggttcca ctggaggcca gtctgtgtcc ggcctccctg     2340

gcaccctcgg gcatctcaga gaagagtaaa tcctcatcat ccttccatcc tgcccctggc     2400

aatgctcaga gctcaagcca gacccccaaa atcgtgaact ttgtctccgt gggacccaca     2460

tacatgaggg tctcttag                                                   2478


<210> 69
<211> 125
<212> PRT
<213> Homo sapiens

<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Leu Ser Ile Thr Ile Arg Pro Arg Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 70
<211> 112
<212> PRT
<213> Homo sapiens

<400> 70
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ile Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ser Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 71
<211> 451
<212> PRT
<213> Homo sapiens

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Leu Ser Ile Thr Ile Arg Pro Arg Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210> 72
<211> 214
<212> PRT
<213> Homo sapiens

<400> 72
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ile Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ser Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe 
    210                 


<210> 73
<211> 327
<212> PRT
<213> Homo sapiens

<400> 73
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 74
<211> 984
<212> DNA
<213> Homo sapiens

<400> 74
gcttccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggctc accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa atga                                             984


<210> 75
<211> 1988
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210> 76
<211> 5965
<212> DNA
<213> Homo sapiens

<400> 76
atggcaatgt tgcctccccc aggacctcag agctttgtcc atttcacaaa acagtctctt       60

gccctcattg aacaacgcat tgctgaaaga aaatcaaagg aacccaaaga agaaaagaaa      120

gatgatgatg aagaagcccc aaagccaagc agtgacttgg aagctggcaa acagctgccc      180

ttcatctatg gggacattcc tcccggcatg gtgtcagagc ccctggagga cttggacccc      240

tactatgcag acaaaaagac tttcatagta ttgaacaaag ggaaaacaat cttccgtttc      300

aatgccacac ctgctttata tatgctttct cctttcagtc ctctaagaag aatatctatt      360

aagattttag tacactcctt attcagcatg ctcatcatgt gcactattct gacaaactgc      420

atatttatga ccatgaataa cccaccggac tggaccaaaa atgtcgagta cacttttact      480

ggaatatata cttttgaatc acttgtaaaa atccttgcaa gaggcttctg tgtaggagaa      540

ttcacttttc ttcgtgaccc gtggaactgg ctggattttg tcgtcattgt ttttgcgtat      600

ttaacagaat ttgtaaacct aggcaatgtt tcagctcttc gaactttcag agtattgaga      660

gctttgaaaa ctatttctgt aatcccaggc ctgaagacaa ttgtaggggc tttgatccag      720

tcagtgaaga agctttctga tgtcatgatc ctgactgtgt tctgtctgag tgtgtttgca      780

ctaattggac tacagctgtt catgggaaac ctgaagcata aatgttttcg aaattcactt      840

gaaaataatg aaacattaga aagcataatg aataccctag agagtgaaga agactttaga      900

aaatattttt attacttgga aggatccaaa gatgctctcc tttgtggttt cagcacagat      960

tcaggtcagt gtccagaggg gtacacctgt gtgaaaattg gcagaaaccc tgattatggc     1020

tacacgagct ttgacacttt cagctgggcc ttcttagcct tgtttaggct aatgacccaa     1080

gattactggg aaaaccttta ccaacagacg ctgcgtgctg ctggcaaaac ctacatgatc     1140

ttctttgtcg tagtgatttt cctgggctcc ttttatctaa taaacttgat cctggctgtg     1200

gttgccatgg catatgaaga acagaaccag gcaaacattg aagaagctaa acagaaagaa     1260

ttagaatttc aacagatgtt agaccgtctt aaaaaagagc aagaagaagc tgaggcaatt     1320

gcagcggcag cggctgaata tacaagtatt aggagaagca gaattatggg cctctcagag     1380

agttcttctg aaacatccaa actgagctct aaaagtgcta aagaaagaag aacagaagaa     1440

agaaaaagaa tcaaaagaag ctctccagtg gagaggaaaa gggagatgct gagaaattgt     1500

cgaaatcaga atcagaggac agcatcagaa gaaaaagttt ccaccttggt gtcgaagggc     1560

ataggcgagc acatgaaaag aggttgtcta cccccaatca gtcaccactc agcattcgtg     1620

gctccttgtt ttctgcaagg cgaagcagca gaacaagtct ttttagtttc aaaggcagag     1680

gaagagatat aggatctgag actgaatttg ccgatgatga gcacagcatt tttggagaca     1740

atgagagcag aaggggctca ctgtttgtgc cccacagacc ccaggagcga cgcagcagta     1800

acatcagcca agccagtagg tccccaccaa tgctgccggt gaacgggaaa atgcacagtg     1860

ctgtggactg caacggtgtg gtctccctgg ttgatggacg ctcagccctc atgctcccca     1920

atggacagct tctgccagag gtgataatag ataaggcaac ttctgatgac agcggcacga     1980

ccaatcaaat acacaagaaa aggcgttgta gttcctatct cctttcagag gatatgctga     2040

atgatcccaa cctcagacag agagcaatga gtagagcaag catattaaca aacactgtgg     2100

aagaacttga agagtccaga caaaaatgtc caccttggtg gtacagattt gcacacaaat     2160

tcttgatctg gaattgctct ccatattgga taaaattcaa aaagtgtatc tattttattg     2220

taatggatcc ttttgtagat cttgcaatta ccatttgcat agttttaaac acattattta     2280

tggctatgga acaccaccca atgactgagg aattcaaaaa tgtactgcta taggaaattt     2340

ggtctttact ggaatctttg cagctgaaat ggtattaaaa ctgattgcca tggatccata     2400

tgagtatttc caagtaggct ggaatatttt tgacagcctt attgtgactt taagtttagt     2460

ggagctcttt ctagcagatg tggaaggatt gtcagttctg cgatcattca gactgctccg     2520

agtcttcaag ttggcaaaat cctggccaac attgaacatg ctgattaaga tcattggtaa     2580

ctcagtaggg gctctaggta acctcacctt agtgttggcc atcatcgtct tcatttttgc     2640

tgtggtcggc atgcagctct ttggtaagag ctacaaagaa tgtgtctgca agatcaatga     2700

tgactgtacg ctcccacggt ggcacatgaa cgacttcttc cactccttcc tgattgtgtt     2760

ccgcgtgctg tgtggagagt ggatagagac catgtgggac tgtatggagg tcgctggtca     2820

agctatgtgc cttattgttt acatgatggt catggtcatt ggaaacctgg tggtcctaaa     2880

cctatttctg gccttattat tgagctcatt tagttcagac aatcttacag caattgaaga     2940

agaccctgat gcaaacaacc tccagattgc agtgactaga attaaaaagg gaataaatta     3000

tgtgaaacaa accttacgtg aatttattct aaaagcattt tccaaaaagc caaagatttc     3060

cagggagata agacaagcag aagatctgaa tactaagaag gaaaactata tttctaacca     3120

tacacttgct gaaatgagca aaggtcacaa tttcctcaag gaaaaagata aaatcagtgg     3180

ttttggaagc agcgtggaca aacacttgat ggaagacagt gatggtcaat catttattca     3240

caatcccagc ctcacagtga cagtgccaat tgcacctggg gaatccgatt tggaaaatat     3300

gaatgctgag gaacttagca gtgattcgga tagtgaatac agcaaagtga gattaaaccg     3360

gtcaagctcc tcagagtgca gcacagttga taaccctttg cctggagaag gagaagaagc     3420

agaggctgaa cctatgaatt ccgatgagcc agaggcctgt ttcacagatg gttgtgtatg     3480

gaggttctca tgctgccaag ttaacataga gtcagggaaa ggaaaaatct ggtggaacat     3540

caggaaaacc tgctacaaga ttgttgaaca cagttggttt gaaagcttca ttgtcctcat     3600

gatcctgctc agcagtggtg ccctggcttt tgaagatatt tatattgaaa ggaaaaagac     3660

cattaagatt atcctggagt atgcagacaa gatcttcact tacatcttca ttctggaaat     3720

gcttctaaaa tggatagcat atggttataa aacatatttc accaatgcct ggtgttggct     3780

ggatttccta attgttgatg tttctttggt tactttagtg gcaaacactc ttggctactc     3840

agatcttggc cccattaaat cccttcggac actgagagct ttaagacctc taagagcctt     3900

atctagattt gaaggaatga gggtcgttgt gaatgcactc ataggagcaa ttccttccat     3960

catgaatgtg ctacttgtgt gtcttatatt ctggctgata ttcagcatca tgggagtaaa     4020

tttgtttgct ggcaagttct atgagtgtat taacaccaca gatgggtcac ggtttcctgc     4080

aagtcaagtt ccaaatcgtt ccgaatgttt tgcccttatg aatgttagtc aaaatgtgcg     4140

atggaaaaac ctgaaagtga actttgataa tgtcggactt ggttacctat ctctgcttca     4200

agttgcaact tttaagggat ggacgattat tatgtatgca gcagtggatt ctgttaatgt     4260

agacaagcag cccaaatatg aatatagcct ctacatgtat atttattttg tcgtctttat     4320

catctttggg tcattcttca ctttgaactt gttcattggt gtcatcatag ataatttcaa     4380

ccaacagaaa aagaagcttg gaggtcaaga catctttatg acagaagaac agaagaaata     4440

ctataatgca atgaaaaagc tggggtccaa gaagccacaa aagccaattc ctcgaccagg     4500

gaacaaaatc caaggatgta tatttgacct agtgacaaat caagcctttg atattagtat     4560

catggttctt atctgtctca acatggtaac catgatggta gaaaaggagg gtcaaagtca     4620

acatatgact gaagttttat attggataaa tgtggttttt ataatccttt tcactggaga     4680

atgtgtgcta aaactgatct ccctcagaca ctactacttc actgtaggat ggaatatttt     4740

tgattttgtg gttgtgatta tctccattgt aggtatgttt ctagctgatt tgattgaaac     4800

gtattttgtg tcccctaccc tgttccgagt gatccgtctt gccaggattg gccgaatcct     4860

acgtctagtc aaaggagcaa aggggatccg cacgctgctc tttgctttga tgatgtccct     4920

tcctgcgttg tttaacatcg gcctcctgct cttcctggtc atgttcatct acgccatctt     4980

tggaatgtcc aactttgcct atgttaaaaa ggaagatgga attaatgaca tgttcaattt     5040

tgagaccttt ggcaacagta tgatttgcct gttccaaatt acaacctctg ctggctggga     5100

tggattgcta gcacctattc ttaacagtaa gccacccgac tgtgacccaa aaaaagttca     5160

tcctggaagt tcagttgaag gagactgtgg taacccatct gttggaatat tctactttgt     5220

tagttatatc atcatatcct tcctggttgt ggtgaacatg tacattgcag tcatactgga     5280

gaattttagt gttgccactg aagaaagtac tgaacctctg agtgaggatg actttgagat     5340

gttctatgag gtttgggaga agtttgatcc cgatgcgacc cagtttatag agttctctaa     5400

actctctgat tttgcagctg ccctggatcc tcctcttctc atagcaaaac ccaacaaagt     5460

ccagctcatt gccatggatc tgcccatggt tagtggtgac cggatccatt gtcttgacat     5520

cttatttgct tttacaaagc gtgttttggg tgagagtggg gagatggatt ctcttcgttc     5580

acagatggaa gaaaggttca tgtctgcaaa tccttccaaa gtgtcctatg aacccatcac     5640

aaccacacta aaacggaaac aagaggatgt gtctgctact gtcattcagc gtgcttatag     5700

acgttaccgc ttaaggcaaa atgtcaaaaa tatatcaagt atatacataa aagatggaga     5760

cagagatgat gatttactca ataaaaaaga tatggctttt gataatgtta atgagaactc     5820

aagtccagaa aaaacagatg ccacttcatc caccacctct ccaccttcat atgatagtgt     5880

aacaaagcca gacaaagaga aatatgaaca agacagaaca gaaaaggaag acaaagggaa     5940

agacagcaag gaaagcaaaa aatag                                           5965


<210> 77

<400> 77
000


<210> 78
<211> 468
<212> PRT
<213> Homo sapiens

<400> 78
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210> 79
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 79
atgctggccg tcggctgcgc gctgctggct gccctgctgg ccgcgccggg agcggcgctg       60

gccccaaggc gctgccctgc gcaggaggtg gcgagaggcg tgctgaccag tctgccagga      120

gacagcgtga ctctgacctg cccgggggta gagccggaag acaatgccac tgttcactgg      180

gtgctcagga agccggctgc aggctcccac cccagcagat gggctggcat gggaaggagg      240

ctgctgctga ggtcggtgca gctccacgac tctggaaact attcatgcta ccgggccggc      300

cgcccagctg ggactgtgca cttgctggtg gatgttcccc ccgaggagcc ccagctctcc      360

tgcttccgga agagccccct cagcaatgtt gtttgtgagt ggggtcctcg gagcacccca      420

tccctgacga caaaggctgt gctcttggtg aggaagtttc agaacagtcc ggccgaagac      480

ttccaggagc cgtgccagta ttcccaggag tcccagaagt tctcctgcca gttagcagtc      540

ccggagggag acagctcttt ctacatagtg tccatgtgcg tcgccagtag tgtcgggagc      600

aagttcagca aaactcaaac ctttcagggt tgtggaatct tgcagcctga tccgcctgcc      660

aacatcacag tcactgccgt ggccagaaac ccccgctggc tcagtgtcac ctggcaagac      720

ccccactcct ggaactcatc tttctacaga ctacggtttg agctcagata tcgggctgaa      780

cggtcaaaga cattcacaac atggatggtc aaggacctcc agcatcactg tgtcatccac      840

gacgcctgga gcggcctgag gcacgtggtg cagcttcgtg cccaggagga gttcgggcaa      900

ggcgagtgga gcgagtggag cccggaggcc atgggcacgc cttggacaga atccaggagt      960

cctccagctg agaacgaggt gtccaccccc atgcaggcac ttactactaa taaagacgat     1020

gataatattc tcttcagaga ttctgcaaat gcgacaagcc tcccagtgca agattcttct     1080

tcagtaccac tgcccacatt cctggttgct ggagggagcc tggccttcgg aacgctcctc     1140

tgcattgcca ttgttctgag gttcaagaag acgtggaagc tgcgggctct gaaggaaggc     1200

aagacaagca tgcatccgcc gtactctttg gggcagctgg tcccggagag gcctcgaccc     1260

accccagtgc ttgttcctct catctcccca ccggtgtccc ccagcagcct ggggtctgac     1320

aatacctcga gccacaaccg accagatgcc agggacccac ggagccctta tgacatcagc     1380

aatacagact acttcttccc cagatag                                         1407


<210> 80
<211> 990
<212> DNA
<213> Homo sapiens

<400> 80
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210> 81
<211> 330
<212> PRT
<213> Homo sapiens

<400> 81
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 82
<211> 978
<212> DNA
<213> Homo sapiens

<400> 82
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210> 83
<211> 326
<212> PRT
<213> Homo sapiens

<400> 83
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 84
<211> 298
<212> DNA
<213> Homo sapiens

<400> 84
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagata        298


<210> 85
<211> 99
<212> PRT
<213> Homo sapiens

<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp 
            


<210> 86
<211> 296
<212> DNA
<213> Homo sapiens

<400> 86
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaga          296


<210> 87
<211> 98
<212> PRT
<213> Homo sapiens

<400> 87
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210> 88
<211> 50
<212> DNA
<213> Homo sapiens

<400> 88
tgatgctttt gatatctggg gccaagggac aatggtcacc gtctcttcag                  50


<210> 89
<211> 16
<212> PRT
<213> Homo sapiens

<400> 89
Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10                  15      


<210> 90
<211> 63
<212> DNA
<213> Homo sapiens

<400> 90
attactacta ctactacggt atggacgtct gggggcaagg gaccacggtc accgtctcct       60

cag                                                                     63


<210> 91
<211> 20
<212> PRT
<213> Homo sapiens

<400> 91
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
1               5                   10                  15      


Thr Val Ser Ser 
            20  


<210> 92
<211> 321
<212> DNA
<213> Homo sapiens

<400> 92
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210> 93
<211> 107
<212> PRT
<213> Homo sapiens

<400> 93
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 94
<211> 312
<212> DNA
<213> Homo sapiens

<400> 94
cccaaggcca accccacggt cactctgttc ccgccctcct ctgaggagct ccaagccaac       60

aaggccacac tagtgtgtct gatcagtgac ttctacccgg gagctgtgac agtggcttgg      120

aaggcagatg gcagccccgt caaggcggga gtggagacga ccaaaccctc caaacagagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      240

agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      300

acagaatgtt ca                                                          312


<210> 95
<211> 104
<212> PRT
<213> Homo sapiens

<400> 95
Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210> 96
<211> 287
<212> DNA
<213> Homo sapiens

<400> 96
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tccctcc                    287


<210> 97
<211> 95
<212> PRT
<213> Homo sapiens

<400> 97
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 
                85                  90                  95  


<210> 98
<211> 287
<212> DNA
<213> Homo sapiens

<400> 98
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctcc                    287


<210> 99
<211> 95
<212> PRT
<213> Homo sapiens

<400> 99
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210> 100
<211> 39
<212> DNA
<213> Homo sapiens

<400> 100
tgtacacttt tggccagggg accaagctgg agatcaaac                              39


<210> 101
<211> 12
<212> PRT
<213> Homo sapiens

<400> 101
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210> 102
<211> 38
<212> DNA
<213> Homo sapiens

<400> 102
gctcactttc ggcggaggga ccaaggtgga gatcaaac                               38


<210> 103
<211> 12
<212> PRT
<213> Homo sapiens

<400> 103
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210> 104
<211> 446
<212> PRT
<213> Homo sapiens

<400> 104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Thr Tyr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210> 105
<211> 214
<212> PRT
<213> Homo sapiens

<400> 105
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 106
<211> 449
<212> PRT
<213> Homo sapiens

<400> 106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 107
<211> 213
<212> PRT
<213> Homo sapiens

<400> 107
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 108
<211> 24
<212> DNA
<213> Homo sapiens

<400> 108
ggattcacct ttgatgatta tgcc                                              24


<210> 109
<211> 8
<212> PRT
<213> Homo sapiens

<400> 109
Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210> 110
<211> 114
<212> DNA
<213> Homo sapiens

<400> 110
ggctatgcgg actctgtgaa gggccgattc accatctcca gagacaacgc caagaactcc       60

ctgtatctgc aaatgaacag tctgagagct gaggacacgg ccttgtatta ctgt            114


<210> 111
<211> 38
<212> PRT
<213> Homo sapiens

<400> 111
Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Leu Tyr Tyr Cys 
        35              


<210> 112
<211> 23
<212> DNA
<213> Homo sapiens

<400> 112
cagcagcgta gcaactggcc tcc                                               23


<210> 113
<211> 7
<212> PRT
<213> Homo sapiens

<400> 113
Gln Gln Arg Ser Asn Trp Pro 
1               5           


<210> 114
<211> 108
<212> DNA
<213> Homo sapiens

<400> 114
aacagggcca ctggcatccc agccaggttc agtggcagtg ggtctgggac agacttcact       60

ctcaccatca gcagcctaga gcctgaagat tttgcagttt attactgt                   108


<210> 115
<211> 36
<212> PRT
<213> Homo sapiens

<400> 115
Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210> 116
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 116
Val Phe Ala Gln Ser Ile Pro 
1               5           


<210> 117
<211> 296
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 117
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ga                                                             296
Ala Lys                                                                   
                                                                          


<210> 118
<211> 98
<212> PRT
<213> Homo sapiens

<400> 118
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 



<210> 119
<211> 294
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 119
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa                                                                294
Ala Lys                                                                   



<210> 120
<211> 296
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 120
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att agt ggt agt ggt ggt agc aca tac tac gga gac tcc gtg        192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Gly Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tca aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ga                                                             296
Ala Lys                                                                   
                                                                          


<210> 121
<211> 98
<212> PRT
<213> Homo sapiens

<400> 121
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 



<210> 122
<211> 294
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 122
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtt att tat agc ggt ggt agt agc aca tac tat gca gac tcc gtg        192
Ser Val Ile Tyr Ser Gly Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gat aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa                                                                294
Ala Lys                                                                   
                                                                          


<210> 123
<211> 98
<212> PRT
<213> Homo sapiens

<400> 123
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        
   
                                                                       
<210> 124
<211> 296
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 124
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtt att tat agc ggt ggt agt agc aca tac tat gca gac tcc gtg        192
Ser Val Ile Tyr Ser Gly Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gat aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ga                                                             296
Ala Lys                                                                   
    

                                                                      
<210> 125
<211> 294
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(294)

<400> 125
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att tat agc agt ggt agt agc aca tac tat gca gac tcc gtg        192
Ser Ala Ile Tyr Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa                                                                294
Ala Lys                                                                   
                                                                          


<210> 126
<211> 98
<212> PRT
<213> Homo sapiens

<400> 126
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210> 127
<211> 431
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210> 128
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 128
Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210> 129
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr 
1               5                   10                  15      


Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys 
            20                  25                  30          


Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr 
        35                  40                  45              


Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His 
    50                  55                  60                  


<210> 130
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Tyr Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly 
1               5                   10                  15      


Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly 
            20                  25                  30          


Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys 
        35                  40                  45              


Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys 
    50                  55                  60                  


Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly 
65                  70                  75                  80  


Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser 
                85                  90                  95      


Thr 
    


<210> 131
<211> 232
<212> PRT
<213> Homo sapiens

<400> 131
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210> 132
<211> 191
<212> PRT
<213> Homo sapiens

<400> 132
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210> 133
<211> 290
<212> PRT
<213> Homo sapiens

<400> 133
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 134
<211> 153
<212> PRT
<213> Homo sapiens

<400> 134
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             



