﻿               SEQUENCE LISTING

<110> LABORATOIRE FRANÇAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

<120> Protéines recombinantes possédant une activité de facteur H

<130> B1740PC00

<160> 159

<170> BiSSAP 1.2

<210> 1
<211> 1213
<212> PRT
<213> Homo sapiens


<400> 1
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 
Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     
Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         
His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             
Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 
Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 
Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     
Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         
Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             
Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 
Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 
Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     
Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         
Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             
Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 
Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 
Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     
Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         
Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             
Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 
Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 
Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     
Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        995                 1000                1005            
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    1010                1015                1020                
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
1025                1030                1035                1040
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                1045                1050                1055    
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            1060                1065                1070        
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        1075                1080                1085            
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    1090                1095                1100                
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
1105                1110                1115                1120
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                1125                1130                1135    
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            1140                1145                1150        
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        1155                1160                1165            
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    1170                1175                1180                
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
1185                1190                1195                1200
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                1205                1210            

<210> 2
<211> 1213
<212> PRT
<213> Homo sapiens


<400> 2
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 
Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     
Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         
His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             
Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn His 
    370                 375                 380                 
Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 
Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     
Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         
Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             
Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 
Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 
Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     
Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         
Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             
Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 
Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 
Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     
Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         
Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             
Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 
Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 
Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     
Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        995                 1000                1005            
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    1010                1015                1020                
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
1025                1030                1035                1040
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                1045                1050                1055    
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            1060                1065                1070        
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        1075                1080                1085            
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    1090                1095                1100                
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
1105                1110                1115                1120
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                1125                1130                1135    
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            1140                1145                1150        
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        1155                1160                1165            
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    1170                1175                1180                
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
1185                1190                1195                1200
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                1205                1210            

<210> 3
<211> 4
<212> PRT
<213> Sequence artificielle

<220> 
<223> linker

<400> 3
Gly Ala Ser Gly 
1               

<210> 4
<211> 60
<212> PRT
<213> Homo sapiens


<400> 4
Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser 
1               5                   10                  15      
Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys 
            20                  25                  30          
Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg Lys 
        35                  40                  45              
Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
    50                  55                  60  

<210> 5
<211> 57
<212> PRT
<213> Homo sapiens


<400> 5
Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly 
1               5                   10                  15      
Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu 
            20                  25                  30          
Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp 
        35                  40                  45              
Gly Trp Thr Asn Asp Ile Pro Ile Cys 
    50                  55          

<210> 6
<211> 60
<212> PRT
<213> Homo sapiens


<400> 6
Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
1               5                   10                  15      
Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
            20                  25                  30          
Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
        35                  40                  45              
Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys 
    50                  55                  60  

<210> 7
<211> 53
<212> PRT
<213> Homo sapiens


<400> 7
Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
1               5                   10                  15      
Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
            20                  25                  30          
Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
        35                  40                  45              
Pro Leu Pro Ser Cys 
    50              

<210> 8
<211> 54
<212> PRT
<213> Homo sapiens


<400> 8
Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile 
1               5                   10                  15      
Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe 
            20                  25                  30          
Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp 
        35                  40                  45              
Ile Pro Ala Pro Arg Cys 
    50                  

<210> 9
<211> 61
<212> PRT
<213> Homo sapiens


<400> 9
Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn Met 
1               5                   10                  15      
Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr Tyr 
            20                  25                  30          
Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His Ile 
        35                  40                  45              
His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys 
    50                  55                  60      

<210> 10
<211> 54
<212> PRT
<213> Homo sapiens


<400> 10
Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly Arg 
1               5                   10                  15      
Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly Tyr 
            20                  25                  30          
Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly Trp 
        35                  40                  45              
Ser Pro Thr Pro Arg Cys 
    50                  

<210> 11
<211> 58
<212> PRT
<213> Homo sapiens


<400> 11
Cys Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser 
1               5                   10                  15      
Gln Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu 
            20                  25                  30          
Gly Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly 
        35                  40                  45              
Lys Asp Gly Trp Ser Ala Gln Pro Thr Cys 
    50                  55              

<210> 12
<211> 56
<212> PRT
<213> Homo sapiens


<400> 12
Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr 
1               5                   10                  15      
Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr 
            20                  25                  30          
Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn 
        35                  40                  45              
Gly Trp Ser Asp Leu Pro Ile Cys 
    50                  55      

<210> 13
<211> 55
<212> PRT
<213> Homo sapiens


<400> 13
Cys Glu Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys 
1               5                   10                  15      
Asp Gln Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly 
            20                  25                  30          
Phe Thr Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu 
        35                  40                  45              
Ser Pro Asp Leu Pro Ile Cys 
    50                  55  

<210> 14
<211> 55
<212> PRT
<213> Homo sapiens


<400> 14
Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr 
1               5                   10                  15      
Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro 
            20                  25                  30          
Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu 
        35                  40                  45              
Trp Thr Thr Leu Pro Val Cys 
    50                  55  

<210> 15
<211> 54
<212> PRT
<213> Homo sapiens


<400> 15
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
1               5                   10                  15      
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
            20                  25                  30          
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
        35                  40                  45              
Thr Gln Leu Pro Gln Cys 
    50                  

<210> 16
<211> 51
<212> PRT
<213> Homo sapiens


<400> 16
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
1               5                   10                  15      
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
            20                  25                  30          
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
        35                  40                  45              
Val Asn Cys 
    50      

<210> 17
<211> 54
<212> PRT
<213> Homo sapiens


<400> 17
Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr 
1               5                   10                  15      
Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn 
            20                  25                  30          
Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp 
        35                  40                  45              
Gln Ser Ile Pro Leu Cys 
    50                  

<210> 18
<211> 57
<212> PRT
<213> Homo sapiens


<400> 18
Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg 
1               5                   10                  15      
Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys 
            20                  25                  30          
Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met 
        35                  40                  45              
Gly Lys Trp Ser Ser Pro Pro Gln Cys 
    50                  55          

<210> 19
<211> 54
<212> PRT
<213> Homo sapiens


<400> 19
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
1               5                   10                  15      
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
            20                  25                  30          
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
        35                  40                  45              
Ser His Pro Pro Ser Cys 
    50                  

<210> 20
<211> 55
<212> PRT
<213> Homo sapiens


<400> 20
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
1               5                   10                  15      
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
            20                  25                  30          
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
        35                  40                  45              
Trp Thr Gly Arg Pro Thr Cys 
    50                  55  

<210> 21
<211> 55
<212> PRT
<213> Homo sapiens


<400> 21
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
1               5                   10                  15      
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
            20                  25                  30          
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
        35                  40                  45              
Trp Thr Glu Pro Pro Gln Cys 
    50                  55  

<210> 22
<211> 55
<212> PRT
<213> Homo sapiens


<400> 22
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
1               5                   10                  15      
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            20                  25                  30          
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        35                  40                  45              
Trp Ser Glu Pro Pro Lys Cys 
    50                  55  

<210> 23
<211> 65
<212> PRT
<213> Homo sapiens


<400> 23
Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
1               5                   10                  15      
Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
            20                  25                  30          
Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
        35                  40                  45              
Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
    50                  55                  60                  
Arg 
65  

<210> 24
<211> 18
<212> PRT
<213> Homo sapiens


<400> 24
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala 
        

<210> 25
<211> 18
<212> PRT
<213> Sequence artificielle

<220> 
<223> peptide signal

<400> 25
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala 
        

<210> 26
<211> 402
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 26
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Gly 
            260                 265                 270         
Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
        275                 280                 285             
Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
    290                 295                 300                 
Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
305                 310                 315                 320 
Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
                325                 330                 335     
Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
            340                 345                 350         
Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
        355                 360                 365             
Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
    370                 375                 380                 
Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His 
385                 390                 395                 400 
His His 
        

<210> 27
<211> 581
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 27
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Lys 
            260                 265                 270         
Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser 
        275                 280                 285             
Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly 
    290                 295                 300                 
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His 
305                 310                 315                 320 
Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu 
                325                 330                 335     
Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu 
            340                 345                 350         
Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser 
        355                 360                 365             
Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg 
    370                 375                 380                 
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
385                 390                 395                 400 
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
                405                 410                 415     
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
            420                 425                 430         
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
        435                 440                 445             
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    450                 455                 460                 
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
465                 470                 475                 480 
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                485                 490                 495     
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            500                 505                 510         
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        515                 520                 525             
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
    530                 535                 540                 
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
545                 550                 555                 560 
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
                565                 570                 575     
His His His His His 
            580     

<210> 28
<211> 642
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 28
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Ser 
            260                 265                 270         
Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser 
        275                 280                 285             
Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly 
    290                 295                 300                 
Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys 
305                 310                 315                 320 
Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro 
                325                 330                 335     
Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr 
            340                 345                 350         
Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly 
        355                 360                 365             
Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser 
    370                 375                 380                 
Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile 
385                 390                 395                 400 
Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr 
                405                 410                 415     
Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr 
            420                 425                 430         
Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser 
        435                 440                 445             
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
    450                 455                 460                 
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
465                 470                 475                 480 
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                485                 490                 495     
Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            500                 505                 510         
Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        515                 520                 525             
Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    530                 535                 540                 
Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
545                 550                 555                 560 
Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                565                 570                 575     
Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
            580                 585                 590         
Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        595                 600                 605             
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    610                 615                 620                 
Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His 
625                 630                 635                 640 
His His 
        

<210> 29
<211> 701
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 29
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Pro 
            260                 265                 270         
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
        275                 280                 285             
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
    290                 295                 300                 
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
305                 310                 315                 320 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
                325                 330                 335     
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
            340                 345                 350         
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
        355                 360                 365             
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
    370                 375                 380                 
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
385                 390                 395                 400 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
                405                 410                 415     
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
            420                 425                 430         
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
        435                 440                 445             
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
    450                 455                 460                 
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
465                 470                 475                 480 
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
                485                 490                 495     
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
            500                 505                 510         
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
        515                 520                 525             
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
    530                 535                 540                 
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
545                 550                 555                 560 
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
                565                 570                 575     
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
            580                 585                 590         
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
        595                 600                 605             
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
    610                 615                 620                 
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
625                 630                 635                 640 
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
                645                 650                 655     
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
            660                 665                 670         
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
        675                 680                 685             
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    690                 695                 700     

<210> 30
<211> 759
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 30
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Lys 
            260                 265                 270         
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
        275                 280                 285             
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
    290                 295                 300                 
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
305                 310                 315                 320 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
                325                 330                 335     
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
            340                 345                 350         
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
        355                 360                 365             
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
    370                 375                 380                 
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
385                 390                 395                 400 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
                405                 410                 415     
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
            420                 425                 430         
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
        435                 440                 445             
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
    450                 455                 460                 
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
465                 470                 475                 480 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
                485                 490                 495     
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
            500                 505                 510         
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
        515                 520                 525             
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
    530                 535                 540                 
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
545                 550                 555                 560 
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
                565                 570                 575     
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
            580                 585                 590         
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
        595                 600                 605             
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
    610                 615                 620                 
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
625                 630                 635                 640 
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
                645                 650                 655     
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
            660                 665                 670         
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
        675                 680                 685             
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
    690                 695                 700                 
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
705                 710                 715                 720 
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
                725                 730                 735     
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
            740                 745                 750         
Gly His His His His His His 
        755                 

<210> 31
<211> 821
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 31
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Gly 
            260                 265                 270         
Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro 
        275                 280                 285             
Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr 
    290                 295                 300                 
Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln 
305                 310                 315                 320 
Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser 
                325                 330                 335     
Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp 
            340                 345                 350         
His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile 
        355                 360                 365             
His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser 
    370                 375                 380                 
Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser 
385                 390                 395                 400 
His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser 
                405                 410                 415     
Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr 
            420                 425                 430         
Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile 
        435                 440                 445             
Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser 
    450                 455                 460                 
Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr 
465                 470                 475                 480 
Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr 
                485                 490                 495     
Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys 
            500                 505                 510         
Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser 
        515                 520                 525             
Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly 
    530                 535                 540                 
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His 
545                 550                 555                 560 
Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu 
                565                 570                 575     
Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu 
            580                 585                 590         
Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser 
        595                 600                 605             
Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg 
    610                 615                 620                 
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
625                 630                 635                 640 
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
                645                 650                 655     
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
            660                 665                 670         
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
        675                 680                 685             
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    690                 695                 700                 
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
705                 710                 715                 720 
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                725                 730                 735     
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            740                 745                 750         
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        755                 760                 765             
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
    770                 775                 780                 
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
785                 790                 795                 800 
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
                805                 810                 815     
His His His His His 
            820     

<210> 32
<211> 882
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 32
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Gly 
            260                 265                 270         
Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu 
        275                 280                 285             
Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe 
    290                 295                 300                 
Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr 
305                 310                 315                 320 
Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro 
                325                 330                 335     
Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr 
            340                 345                 350         
Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly 
        355                 360                 365             
His Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln 
    370                 375                 380                 
Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile 
385                 390                 395                 400 
Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser 
                405                 410                 415     
Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val 
            420                 425                 430         
Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln 
        435                 440                 445             
Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met 
    450                 455                 460                 
Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys 
465                 470                 475                 480 
Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp 
                485                 490                 495     
Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser 
            500                 505                 510         
Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser 
        515                 520                 525             
Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly 
    530                 535                 540                 
Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys 
545                 550                 555                 560 
Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro 
                565                 570                 575     
Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr 
            580                 585                 590         
Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly 
        595                 600                 605             
Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser 
    610                 615                 620                 
Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile 
625                 630                 635                 640 
Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr 
                645                 650                 655     
Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr 
            660                 665                 670         
Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser 
        675                 680                 685             
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
    690                 695                 700                 
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
705                 710                 715                 720 
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                725                 730                 735     
Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            740                 745                 750         
Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        755                 760                 765             
Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    770                 775                 780                 
Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
785                 790                 795                 800 
Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                805                 810                 815     
Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
            820                 825                 830         
Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        835                 840                 845             
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    850                 855                 860                 
Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His 
865                 870                 875                 880 
His His 
        

<210> 33
<211> 943
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 33
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Glu 
            260                 265                 270         
Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln 
        275                 280                 285             
Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr 
    290                 295                 300                 
Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro 
305                 310                 315                 320 
Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro 
                325                 330                 335     
Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly 
            340                 345                 350         
His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys 
        355                 360                 365             
Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro 
    370                 375                 380                 
Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu 
385                 390                 395                 400 
His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser 
                405                 410                 415     
Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser 
            420                 425                 430         
Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala 
        435                 440                 445             
Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu 
    450                 455                 460                 
Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg 
465                 470                 475                 480 
Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn 
                485                 490                 495     
Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu 
            500                 505                 510         
Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr 
        515                 520                 525             
Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn 
    530                 535                 540                 
Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp 
545                 550                 555                 560 
Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro 
                565                 570                 575     
Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser 
            580                 585                 590         
Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg 
        595                 600                 605             
Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser 
    610                 615                 620                 
Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser 
625                 630                 635                 640 
His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu 
                645                 650                 655     
Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile 
            660                 665                 670         
Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys 
        675                 680                 685             
Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly 
    690                 695                 700                 
Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys 
705                 710                 715                 720 
Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn 
                725                 730                 735     
Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn 
            740                 745                 750         
Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys 
        755                 760                 765             
Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
    770                 775                 780                 
Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 
785                 790                 795                 800 
Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
                805                 810                 815     
Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
            820                 825                 830         
Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
        835                 840                 845             
Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
    850                 855                 860                 
Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
865                 870                 875                 880 
Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
                885                 890                 895     
Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
            900                 905                 910         
Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
        915                 920                 925             
Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    930                 935                 940             

<210> 34
<211> 1003
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 34
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Asp 
            260                 265                 270         
Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe 
        275                 280                 285             
Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser 
    290                 295                 300                 
Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp 
305                 310                 315                 320 
Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile 
                325                 330                 335     
Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly 
            340                 345                 350         
Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro 
        355                 360                 365             
Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile 
    370                 375                 380                 
Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn 
385                 390                 395                 400 
Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val 
                405                 410                 415     
Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys 
            420                 425                 430         
Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val 
        435                 440                 445             
Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala 
    450                 455                 460                 
Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn 
465                 470                 475                 480 
Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile 
                485                 490                 495     
His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu 
            500                 505                 510         
Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys 
        515                 520                 525             
Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg 
    530                 535                 540                 
Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp 
545                 550                 555                 560 
Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro 
                565                 570                 575     
Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg 
            580                 585                 590         
Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln 
        595                 600                 605             
Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro 
    610                 615                 620                 
Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His 
625                 630                 635                 640 
Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly 
                645                 650                 655     
Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu 
            660                 665                 670         
Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys 
        675                 680                 685             
Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val 
    690                 695                 700                 
Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys 
705                 710                 715                 720 
Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu 
                725                 730                 735     
Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu 
            740                 745                 750         
Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp 
        755                 760                 765             
Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr 
    770                 775                 780                 
Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr 
785                 790                 795                 800 
Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val 
                805                 810                 815     
Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly 
            820                 825                 830         
Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp 
        835                 840                 845             
Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys 
    850                 855                 860                 
Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
865                 870                 875                 880 
Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
                885                 890                 895     
Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
            900                 905                 910         
Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
        915                 920                 925             
Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
    930                 935                 940                 
Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
945                 950                 955                 960 
Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
                965                 970                 975     
Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
            980                 985                 990         
Arg Gly Gly Ser Gly His His His His His His 
        995                 1000            

<210> 35
<211> 1064
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 35
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Cys Ser 
            260                 265                 270         
Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr 
        275                 280                 285             
Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr 
    290                 295                 300                 
Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp 
305                 310                 315                 320 
Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val 
                325                 330                 335     
Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn 
            340                 345                 350         
Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly 
        355                 360                 365             
Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu 
    370                 375                 380                 
Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His 
385                 390                 395                 400 
Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu 
                405                 410                 415     
Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val 
            420                 425                 430         
Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu 
        435                 440                 445             
Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val 
    450                 455                 460                 
Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr 
465                 470                 475                 480 
Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys 
                485                 490                 495     
Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser 
            500                 505                 510         
Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser 
        515                 520                 525             
Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu 
    530                 535                 540                 
Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val 
545                 550                 555                 560 
Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys 
                565                 570                 575     
Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys 
            580                 585                 590         
Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu 
        595                 600                 605             
Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val 
    610                 615                 620                 
Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile 
625                 630                 635                 640 
Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu 
                645                 650                 655     
Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu 
            660                 665                 670         
Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val 
        675                 680                 685             
Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile 
    690                 695                 700                 
Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu 
705                 710                 715                 720 
Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr 
                725                 730                 735     
Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu 
            740                 745                 750         
Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met 
        755                 760                 765             
Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu 
    770                 775                 780                 
Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys 
785                 790                 795                 800 
Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro 
                805                 810                 815     
Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys 
            820                 825                 830         
Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp 
        835                 840                 845             
Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro 
    850                 855                 860                 
Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala 
865                 870                 875                 880 
Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val 
                885                 890                 895     
Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val 
            900                 905                 910         
Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser 
        915                 920                 925             
Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
    930                 935                 940                 
Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
945                 950                 955                 960 
Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
                965                 970                 975     
Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
            980                 985                 990         
Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
        995                 1000                1005            
Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
    1010                1015                1020                
Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
1025                1030                1035                1040
Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly 
                1045                1050                1055    
Ser Gly His His His His His His 
            1060                

<210> 36
<211> 584
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 36
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
    450                 455                 460                 
Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
465                 470                 475                 480 
Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
                485                 490                 495     
Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
            500                 505                 510         
Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
        515                 520                 525             
Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
    530                 535                 540                 
Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
545                 550                 555                 560 
Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly 
                565                 570                 575     
Ser Gly His His His His His His 
            580                 

<210> 37
<211> 762
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 37
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala 
    450                 455                 460                 
His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys 
465                 470                 475                 480 
Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly 
                485                 490                 495     
Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser 
            500                 505                 510         
Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val 
        515                 520                 525             
Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys 
    530                 535                 540                 
Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly 
545                 550                 555                 560 
Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln 
                565                 570                 575     
Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu 
            580                 585                 590         
Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu 
        595                 600                 605             
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys 
    610                 615                 620                 
Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
625                 630                 635                 640 
Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
                645                 650                 655     
Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
            660                 665                 670         
Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
        675                 680                 685             
Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
    690                 695                 700                 
Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
705                 710                 715                 720 
Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
                725                 730                 735     
Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            740                 745                 750         
Gly Gly Ser Gly His His His His His His 
        755                 760         

<210> 38
<211> 823
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 38
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    450                 455                 460                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
465                 470                 475                 480 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                485                 490                 495     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            500                 505                 510         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        515                 520                 525             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    530                 535                 540                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
545                 550                 555                 560 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                565                 570                 575     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            580                 585                 590         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        595                 600                 605             
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    610                 615                 620                 
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
625                 630                 635                 640 
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                645                 650                 655     
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            660                 665                 670         
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        675                 680                 685             
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    690                 695                 700                 
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
705                 710                 715                 720 
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                725                 730                 735     
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            740                 745                 750         
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        755                 760                 765             
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    770                 775                 780                 
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
785                 790                 795                 800 
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
                805                 810                 815     
Gly His His His His His His 
            820             

<210> 39
<211> 882
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 39
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met 
    450                 455                 460                 
Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys 
465                 470                 475                 480 
Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp 
                485                 490                 495     
Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser 
            500                 505                 510         
Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser 
        515                 520                 525             
Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly 
    530                 535                 540                 
Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys 
545                 550                 555                 560 
Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro 
                565                 570                 575     
Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr 
            580                 585                 590         
Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly 
        595                 600                 605             
Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser 
    610                 615                 620                 
Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile 
625                 630                 635                 640 
Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr 
                645                 650                 655     
Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr 
            660                 665                 670         
Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser 
        675                 680                 685             
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
    690                 695                 700                 
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
705                 710                 715                 720 
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                725                 730                 735     
Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            740                 745                 750         
Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        755                 760                 765             
Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    770                 775                 780                 
Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
785                 790                 795                 800 
Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                805                 810                 815     
Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
            820                 825                 830         
Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        835                 840                 845             
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    850                 855                 860                 
Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His 
865                 870                 875                 880 
His His 
        

<210> 40
<211> 940
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 40
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu 
    450                 455                 460                 
Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys 
465                 470                 475                 480 
Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp 
                485                 490                 495     
Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro 
            500                 505                 510         
Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr 
        515                 520                 525             
Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile 
    530                 535                 540                 
Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile 
545                 550                 555                 560 
Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu 
                565                 570                 575     
His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His 
            580                 585                 590         
Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu 
        595                 600                 605             
Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln 
    610                 615                 620                 
Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val 
625                 630                 635                 640 
Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr 
                645                 650                 655     
Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys 
            660                 665                 670         
Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys 
        675                 680                 685             
Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys 
    690                 695                 700                 
Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr 
705                 710                 715                 720 
Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp 
                725                 730                 735     
Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr 
            740                 745                 750         
Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser 
        755                 760                 765             
Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly 
    770                 775                 780                 
Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln 
785                 790                 795                 800 
Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn 
                805                 810                 815     
Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser 
            820                 825                 830         
Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg 
        835                 840                 845             
Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His 
    850                 855                 860                 
Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu 
865                 870                 875                 880 
Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val 
                885                 890                 895     
Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr 
            900                 905                 910         
Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala 
        915                 920                 925             
Lys Arg Gly Gly Ser Gly His His His His His His 
    930                 935                 940 

<210> 41
<211> 1002
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 41
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln 
    450                 455                 460                 
Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys 
465                 470                 475                 480 
Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His 
                485                 490                 495     
Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys 
            500                 505                 510         
Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn 
        515                 520                 525             
Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly 
    530                 535                 540                 
Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro 
545                 550                 555                 560 
Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro 
                565                 570                 575     
Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp 
            580                 585                 590         
Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu 
        595                 600                 605             
Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu 
    610                 615                 620                 
Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly 
625                 630                 635                 640 
Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr 
                645                 650                 655     
Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn 
            660                 665                 670         
Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu 
        675                 680                 685             
Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala 
    690                 695                 700                 
His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys 
705                 710                 715                 720 
Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly 
                725                 730                 735     
Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser 
            740                 745                 750         
Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val 
        755                 760                 765             
Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys 
    770                 775                 780                 
Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly 
785                 790                 795                 800 
Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln 
                805                 810                 815     
Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu 
            820                 825                 830         
Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu 
        835                 840                 845             
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys 
    850                 855                 860                 
Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
865                 870                 875                 880 
Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
                885                 890                 895     
Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
            900                 905                 910         
Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
        915                 920                 925             
Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
    930                 935                 940                 
Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
945                 950                 955                 960 
Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
                965                 970                 975     
Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            980                 985                 990         
Gly Gly Ser Gly His His His His His His 
        995                 1000        

<210> 42
<211> 1063
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 42
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    450                 455                 460                 
Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
465                 470                 475                 480 
Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                485                 490                 495     
Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            500                 505                 510         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        515                 520                 525             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    530                 535                 540                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
545                 550                 555                 560 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                565                 570                 575     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            580                 585                 590         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        595                 600                 605             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    610                 615                 620                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
625                 630                 635                 640 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                645                 650                 655     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            660                 665                 670         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        675                 680                 685             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    690                 695                 700                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
705                 710                 715                 720 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                725                 730                 735     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            740                 745                 750         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        755                 760                 765             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    770                 775                 780                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
785                 790                 795                 800 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                805                 810                 815     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            820                 825                 830         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        835                 840                 845             
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    850                 855                 860                 
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
865                 870                 875                 880 
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                885                 890                 895     
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            900                 905                 910         
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        915                 920                 925             
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    930                 935                 940                 
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
945                 950                 955                 960 
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                965                 970                 975     
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            980                 985                 990         
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        995                 1000                1005            
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    1010                1015                1020                
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
1025                1030                1035                1040
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
                1045                1050                1055    
Gly His His His His His His 
            1060            

<210> 43
<211> 1124
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 43
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Glu Leu Pro Lys Ile Asp Val His Leu Val Pro Asp 
    450                 455                 460                 
Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys 
465                 470                 475                 480 
Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His 
                485                 490                 495     
Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser 
            500                 505                 510         
Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr 
        515                 520                 525             
Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro 
    530                 535                 540                 
Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu 
545                 550                 555                 560 
Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp 
                565                 570                 575     
Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr 
            580                 585                 590         
Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met 
        595                 600                 605             
Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu 
    610                 615                 620                 
Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn 
625                 630                 635                 640 
Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His 
                645                 650                 655     
Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His 
            660                 665                 670         
Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met 
        675                 680                 685             
Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His 
    690                 695                 700                 
Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val 
705                 710                 715                 720 
Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys 
                725                 730                 735     
Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro 
            740                 745                 750         
Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg 
        755                 760                 765             
Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys 
    770                 775                 780                 
Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met 
785                 790                 795                 800 
Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser 
                805                 810                 815     
Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr 
            820                 825                 830         
Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile 
        835                 840                 845             
Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro 
    850                 855                 860                 
Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn 
865                 870                 875                 880 
Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln 
                885                 890                 895     
Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn 
            900                 905                 910         
Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp 
        915                 920                 925             
Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser 
    930                 935                 940                 
Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys 
945                 950                 955                 960 
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
                965                 970                 975     
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
            980                 985                 990         
Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
        995                 1000                1005            
Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
    1010                1015                1020                
Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
1025                1030                1035                1040
Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
                1045                1050                1055    
Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
            1060                1065                1070        
Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr 
        1075                1080                1085            
Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
    1090                1095                1100                
Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His 
1105                1110                1115                1120
His His His His 
                

<210> 44
<211> 1184
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 44
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn 
    450                 455                 460                 
Asp Phe Thr Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His 
465                 470                 475                 480 
Asp Gly Tyr Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys 
                485                 490                 495     
Gly Tyr Asn Gly Trp Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys 
            500                 505                 510         
Glu Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp 
        515                 520                 525             
Gln Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe 
    530                 535                 540                 
Thr Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser 
545                 550                 555                 560 
Pro Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro 
                565                 570                 575     
Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr 
            580                 585                 590         
Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met 
        595                 600                 605             
Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu 
    610                 615                 620                 
Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu 
625                 630                 635                 640 
Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp 
                645                 650                 655     
Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg 
            660                 665                 670         
Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val 
        675                 680                 685             
Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu 
    690                 695                 700                 
Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile 
705                 710                 715                 720 
Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile 
                725                 730                 735     
Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln 
            740                 745                 750         
Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr 
        755                 760                 765             
Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu 
    770                 775                 780                 
Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg 
785                 790                 795                 800 
Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro 
                805                 810                 815     
Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu 
            820                 825                 830         
Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe 
        835                 840                 845             
Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser 
    850                 855                 860                 
Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile 
865                 870                 875                 880 
Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu 
                885                 890                 895     
Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala 
            900                 905                 910         
Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile 
        915                 920                 925             
Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met 
    930                 935                 940                 
Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr 
945                 950                 955                 960 
Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile 
                965                 970                 975     
Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val 
            980                 985                 990         
Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
        995                 1000                1005            
Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
    1010                1015                1020                
Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
1025                1030                1035                1040
Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
                1045                1050                1055    
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
            1060                1065                1070        
Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
        1075                1080                1085            
Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
    1090                1095                1100                
Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
1105                1110                1115                1120
Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
                1125                1130                1135    
Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
            1140                1145                1150        
Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
        1155                1160                1165            
Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    1170                1175                1180                



<210> 45
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 45
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly 
        435                 440                 445             
Ala Ser Gly Cys Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile 
    450                 455                 460                 
Ser Glu Ser Gln Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln 
465                 470                 475                 480 
Cys Lys Leu Gly Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile 
                485                 490                 495     
Thr Cys Gly Lys Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser 
            500                 505                 510         
Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr 
        515                 520                 525             
Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr 
    530                 535                 540                 
Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn 
545                 550                 555                 560 
Gly Trp Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro 
                565                 570                 575     
Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys 
            580                 585                 590         
Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val 
        595                 600                 605             
Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu 
    610                 615                 620                 
Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu 
625                 630                 635                 640 
Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser 
                645                 650                 655     
Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro 
            660                 665                 670         
Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys 
        675                 680                 685             
Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly 
    690                 695                 700                 
Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu 
705                 710                 715                 720 
Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr 
                725                 730                 735     
Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp 
            740                 745                 750         
Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 46
<211> 645
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 46
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
        515                 520                 525             
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
    530                 535                 540                 
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
545                 550                 555                 560 
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
                565                 570                 575     
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
            580                 585                 590         
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
        595                 600                 605             
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
    610                 615                 620                 
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
625                 630                 635                 640 
His His His His His 
                645 

<210> 47
<211> 823
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 47
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        515                 520                 525             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    530                 535                 540                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
545                 550                 555                 560 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                565                 570                 575     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            580                 585                 590         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        595                 600                 605             
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    610                 615                 620                 
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
625                 630                 635                 640 
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                645                 650                 655     
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            660                 665                 670         
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        675                 680                 685             
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    690                 695                 700                 
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
705                 710                 715                 720 
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                725                 730                 735     
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            740                 745                 750         
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        755                 760                 765             
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    770                 775                 780                 
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
785                 790                 795                 800 
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
                805                 810                 815     
Gly His His His His His His 
            820             

<210> 48
<211> 884
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 48
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg 
        515                 520                 525             
Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys 
    530                 535                 540                 
Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met 
545                 550                 555                 560 
Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser 
                565                 570                 575     
Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr 
            580                 585                 590         
Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile 
        595                 600                 605             
Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro 
    610                 615                 620                 
Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn 
625                 630                 635                 640 
Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln 
                645                 650                 655     
Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn 
            660                 665                 670         
Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp 
        675                 680                 685             
Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser 
    690                 695                 700                 
Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys 
705                 710                 715                 720 
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
                725                 730                 735     
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
            740                 745                 750         
Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
        755                 760                 765             
Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
    770                 775                 780                 
Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
785                 790                 795                 800 
Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
                805                 810                 815     
Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
            820                 825                 830         
Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr 
        835                 840                 845             
Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
    850                 855                 860                 
Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His 
865                 870                 875                 880 
His His His His 
                

<210> 49
<211> 943
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 49
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr 
        515                 520                 525             
Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn 
    530                 535                 540                 
Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp 
545                 550                 555                 560 
Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro 
                565                 570                 575     
Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser 
            580                 585                 590         
Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg 
        595                 600                 605             
Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser 
    610                 615                 620                 
Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser 
625                 630                 635                 640 
His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu 
                645                 650                 655     
Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile 
            660                 665                 670         
Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys 
        675                 680                 685             
Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly 
    690                 695                 700                 
Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys 
705                 710                 715                 720 
Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn 
                725                 730                 735     
Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn 
            740                 745                 750         
Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys 
        755                 760                 765             
Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
    770                 775                 780                 
Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 
785                 790                 795                 800 
Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
                805                 810                 815     
Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
            820                 825                 830         
Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
        835                 840                 845             
Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
    850                 855                 860                 
Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
865                 870                 875                 880 
Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
                885                 890                 895     
Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
            900                 905                 910         
Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
        915                 920                 925             
Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    930                 935                 940             

<210> 50
<211> 1001
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 50
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        515                 520                 525             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    530                 535                 540                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
545                 550                 555                 560 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                565                 570                 575     
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            580                 585                 590         
Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        595                 600                 605             
Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    610                 615                 620                 
Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
625                 630                 635                 640 
Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                645                 650                 655     
Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            660                 665                 670         
Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        675                 680                 685             
Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    690                 695                 700                 
Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
705                 710                 715                 720 
Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                725                 730                 735     
Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            740                 745                 750         
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
        755                 760                 765             
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
    770                 775                 780                 
Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
785                 790                 795                 800 
Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
                805                 810                 815     
Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
            820                 825                 830         
Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
        835                 840                 845             
Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp 
    850                 855                 860                 
Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
865                 870                 875                 880 
Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
                885                 890                 895     
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
            900                 905                 910         
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
        915                 920                 925             
Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
    930                 935                 940                 
Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
945                 950                 955                 960 
Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
                965                 970                 975     
Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly 
            980                 985                 990         
Gly Ser Gly His His His His His His 
        995                 1000    

<210> 51
<211> 1063
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 51
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        515                 520                 525             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    530                 535                 540                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
545                 550                 555                 560 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                565                 570                 575     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            580                 585                 590         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        595                 600                 605             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    610                 615                 620                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
625                 630                 635                 640 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                645                 650                 655     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            660                 665                 670         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        675                 680                 685             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    690                 695                 700                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
705                 710                 715                 720 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                725                 730                 735     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            740                 745                 750         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        755                 760                 765             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    770                 775                 780                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
785                 790                 795                 800 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                805                 810                 815     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            820                 825                 830         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        835                 840                 845             
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    850                 855                 860                 
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
865                 870                 875                 880 
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                885                 890                 895     
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            900                 905                 910         
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        915                 920                 925             
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    930                 935                 940                 
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
945                 950                 955                 960 
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                965                 970                 975     
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            980                 985                 990         
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        995                 1000                1005            
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    1010                1015                1020                
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
1025                1030                1035                1040
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
                1045                1050                1055    
Gly His His His His His His 
            1060            

<210> 52
<211> 1124
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 52
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr 
        515                 520                 525             
Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro 
    530                 535                 540                 
Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu 
545                 550                 555                 560 
Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp 
                565                 570                 575     
Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr 
            580                 585                 590         
Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met 
        595                 600                 605             
Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu 
    610                 615                 620                 
Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn 
625                 630                 635                 640 
Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His 
                645                 650                 655     
Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His 
            660                 665                 670         
Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met 
        675                 680                 685             
Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His 
    690                 695                 700                 
Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val 
705                 710                 715                 720 
Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys 
                725                 730                 735     
Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro 
            740                 745                 750         
Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg 
        755                 760                 765             
Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys 
    770                 775                 780                 
Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met 
785                 790                 795                 800 
Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser 
                805                 810                 815     
Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr 
            820                 825                 830         
Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile 
        835                 840                 845             
Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro 
    850                 855                 860                 
Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn 
865                 870                 875                 880 
Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln 
                885                 890                 895     
Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn 
            900                 905                 910         
Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp 
        915                 920                 925             
Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser 
    930                 935                 940                 
Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys 
945                 950                 955                 960 
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
                965                 970                 975     
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
            980                 985                 990         
Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
        995                 1000                1005            
Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
    1010                1015                1020                
Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
1025                1030                1035                1040
Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
                1045                1050                1055    
Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
            1060                1065                1070        
Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr 
        1075                1080                1085            
Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
    1090                1095                1100                
Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His 
1105                1110                1115                1120
His His His His 
                

<210> 53
<211> 1185
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 53
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Glu Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys 
        515                 520                 525             
Asp Gln Tyr Lys Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly 
    530                 535                 540                 
Phe Thr Ile Val Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu 
545                 550                 555                 560 
Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro 
                565                 570                 575     
Pro Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu 
            580                 585                 590         
Tyr Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu 
        595                 600                 605             
Met Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr 
    610                 615                 620                 
Leu Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu 
625                 630                 635                 640 
Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly 
                645                 650                 655     
Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His 
            660                 665                 670         
Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys 
        675                 680                 685             
Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile 
    690                 695                 700                 
Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn 
705                 710                 715                 720 
Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys 
                725                 730                 735     
Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile 
            740                 745                 750         
Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr 
        755                 760                 765             
Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln 
    770                 775                 780                 
Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly 
785                 790                 795                 800 
Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln 
                805                 810                 815     
Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln 
            820                 825                 830         
Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly 
        835                 840                 845             
Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp 
    850                 855                 860                 
Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu 
865                 870                 875                 880 
Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly 
                885                 890                 895     
Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro 
            900                 905                 910         
Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys 
        915                 920                 925             
Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro 
    930                 935                 940                 
Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr 
945                 950                 955                 960 
Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys 
                965                 970                 975     
Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys 
            980                 985                 990         
Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met 
        995                 1000                1005            
Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro 
    1010                1015                1020                
Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp 
1025                1030                1035                1040
Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro 
                1045                1050                1055    
Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr 
            1060                1065                1070        
Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu 
        1075                1080                1085            
Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro 
    1090                1095                1100                
Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn 
1105                1110                1115                1120
Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg 
                1125                1130                1135    
Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser 
            1140                1145                1150        
Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu 
        1155                1160                1165            
Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His 
    1170                1175                1180                
His 
1185

<210> 54
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 54
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Gly Ala Ser Gly 
            500                 505                 510         
Cys Asp Ile Pro Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr 
        515                 520                 525             
Trp Phe Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr 
    530                 535                 540                 
Glu Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn 
545                 550                 555                 560 
Gly Trp Ser Asp Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro 
                565                 570                 575     
Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys 
            580                 585                 590         
Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val 
        595                 600                 605             
Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu 
    610                 615                 620                 
Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu 
625                 630                 635                 640 
Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser 
                645                 650                 655     
Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro 
            660                 665                 670         
Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys 
        675                 680                 685             
Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly 
    690                 695                 700                 
Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu 
705                 710                 715                 720 
Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr 
                725                 730                 735     
Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp 
            740                 745                 750         
Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 55
<211> 705
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 55
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Gly Pro Pro 
                565                 570                 575     
Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr 
            580                 585                 590         
Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu 
        595                 600                 605             
Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro 
    610                 615                 620                 
Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn 
625                 630                 635                 640 
Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg 
                645                 650                 655     
Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser 
            660                 665                 670         
Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu 
        675                 680                 685             
Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His 
    690                 695                 700                 
His 
705 

<210> 56
<211> 883
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 56
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Lys Ser Pro 
                565                 570                 575     
Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln 
            580                 585                 590         
Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp 
        595                 600                 605             
Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro 
    610                 615                 620                 
Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala 
625                 630                 635                 640 
Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val 
                645                 650                 655     
Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val 
            660                 665                 670         
Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr 
        675                 680                 685             
Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg 
    690                 695                 700                 
Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg 
705                 710                 715                 720 
Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly 
                725                 730                 735     
Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly 
            740                 745                 750         
Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
        755                 760                 765             
Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
    770                 775                 780                 
Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
785                 790                 795                 800 
Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
                805                 810                 815     
Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
            820                 825                 830         
Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
        835                 840                 845             
Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
    850                 855                 860                 
Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His 
865                 870                 875                 880 
His His His 
            

<210> 57
<211> 944
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 57
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Ser Gln Pro 
                565                 570                 575     
Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu 
            580                 585                 590         
Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe 
        595                 600                 605             
Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser 
    610                 615                 620                 
Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile 
625                 630                 635                 640 
Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu 
                645                 650                 655     
Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala 
            660                 665                 670         
Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile 
        675                 680                 685             
Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met 
    690                 695                 700                 
Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr 
705                 710                 715                 720 
Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile 
                725                 730                 735     
Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val 
            740                 745                 750         
Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
        755                 760                 765             
Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
    770                 775                 780                 
Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
785                 790                 795                 800 
Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
                805                 810                 815     
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
            820                 825                 830         
Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
        835                 840                 845             
Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
    850                 855                 860                 
Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
865                 870                 875                 880 
Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
                885                 890                 895     
Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
            900                 905                 910         
Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
        915                 920                 925             
Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    930                 935                 940                 



<210> 58
<211> 1003
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 58
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Pro Pro Pro 
                565                 570                 575     
Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg 
            580                 585                 590         
Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln 
        595                 600                 605             
Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro 
    610                 615                 620                 
Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His 
625                 630                 635                 640 
Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly 
                645                 650                 655     
Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu 
            660                 665                 670         
Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys 
        675                 680                 685             
Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val 
    690                 695                 700                 
Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys 
705                 710                 715                 720 
Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu 
                725                 730                 735     
Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu 
            740                 745                 750         
Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp 
        755                 760                 765             
Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr 
    770                 775                 780                 
Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr 
785                 790                 795                 800 
Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val 
                805                 810                 815     
Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly 
            820                 825                 830         
Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp 
        835                 840                 845             
Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys 
    850                 855                 860                 
Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
865                 870                 875                 880 
Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
                885                 890                 895     
Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
            900                 905                 910         
Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
        915                 920                 925             
Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
    930                 935                 940                 
Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
945                 950                 955                 960 
Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
                965                 970                 975     
Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
            980                 985                 990         
Arg Gly Gly Ser Gly His His His His His His 
        995                 1000            

<210> 59
<211> 1061
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 59
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Lys Ser Ser 
                565                 570                 575     
Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp 
            580                 585                 590         
His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile 
        595                 600                 605             
His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser 
    610                 615                 620                 
Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser 
625                 630                 635                 640 
His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser 
                645                 650                 655     
Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr 
            660                 665                 670         
Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile 
        675                 680                 685             
Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser 
    690                 695                 700                 
Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr 
705                 710                 715                 720 
Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr 
                725                 730                 735     
Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys 
            740                 745                 750         
Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser 
        755                 760                 765             
Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly 
    770                 775                 780                 
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His 
785                 790                 795                 800 
Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu 
                805                 810                 815     
Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu 
            820                 825                 830         
Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser 
        835                 840                 845             
Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg 
    850                 855                 860                 
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
865                 870                 875                 880 
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
                885                 890                 895     
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
            900                 905                 910         
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
        915                 920                 925             
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    930                 935                 940                 
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
945                 950                 955                 960 
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                965                 970                 975     
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            980                 985                 990         
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        995                 1000                1005            
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
    1010                1015                1020                
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
1025                1030                1035                1040
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
                1045                1050                1055    
His His His His His 
            1060    

<210> 60
<211> 1123
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 60
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Gly Asp Ile 
                565                 570                 575     
Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr 
            580                 585                 590         
Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile 
        595                 600                 605             
Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro 
    610                 615                 620                 
Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu 
625                 630                 635                 640 
Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn 
                645                 650                 655     
Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr 
            660                 665                 670         
Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala 
        675                 680                 685             
Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn 
    690                 695                 700                 
Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu 
705                 710                 715                 720 
Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys 
                725                 730                 735     
Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys 
            740                 745                 750         
Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser 
        755                 760                 765             
Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu 
    770                 775                 780                 
Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly 
785                 790                 795                 800 
Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro 
                805                 810                 815     
Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln 
            820                 825                 830         
Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp 
        835                 840                 845             
Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro 
    850                 855                 860                 
Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala 
865                 870                 875                 880 
Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val 
                885                 890                 895     
Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val 
            900                 905                 910         
Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr 
        915                 920                 925             
Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg 
    930                 935                 940                 
Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg 
945                 950                 955                 960 
Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly 
                965                 970                 975     
Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly 
            980                 985                 990         
Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
        995                 1000                1005            
Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
    1010                1015                1020                
Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
1025                1030                1035                1040
Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
                1045                1050                1055    
Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
            1060                1065                1070        
Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
        1075                1080                1085            
Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
    1090                1095                1100                
Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His 
1105                1110                1115                1120
His His His 
            

<210> 61
<211> 1184
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 61
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Gly Pro Pro 
                565                 570                 575     
Pro Glu Leu Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr 
            580                 585                 590         
Gly His Ser Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met 
        595                 600                 605             
Lys Gly Pro Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu 
    610                 615                 620                 
Pro Val Cys Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu 
625                 630                 635                 640 
Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp 
                645                 650                 655     
Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg 
            660                 665                 670         
Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val 
        675                 680                 685             
Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu 
    690                 695                 700                 
Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile 
705                 710                 715                 720 
Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile 
                725                 730                 735     
Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln 
            740                 745                 750         
Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr 
        755                 760                 765             
Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu 
    770                 775                 780                 
Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg 
785                 790                 795                 800 
Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro 
                805                 810                 815     
Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu 
            820                 825                 830         
Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe 
        835                 840                 845             
Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser 
    850                 855                 860                 
Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile 
865                 870                 875                 880 
Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu 
                885                 890                 895     
Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala 
            900                 905                 910         
Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile 
        915                 920                 925             
Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met 
    930                 935                 940                 
Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr 
945                 950                 955                 960 
Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile 
                965                 970                 975     
Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val 
            980                 985                 990         
Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
        995                 1000                1005            
Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
    1010                1015                1020                
Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
1025                1030                1035                1040
Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
                1045                1050                1055    
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
            1060                1065                1070        
Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
        1075                1080                1085            
Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
    1090                1095                1100                
Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
1105                1110                1115                1120
Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
                1125                1130                1135    
Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
            1140                1145                1150        
Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
        1155                1160                1165            
Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    1170                1175                1180                



<210> 62
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 62
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Gly Ala Ser Gly Cys Glu Leu Pro 
                565                 570                 575     
Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys 
            580                 585                 590         
Val Gly Glu Val Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val 
        595                 600                 605             
Gly Pro Asn Ser Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu 
    610                 615                 620                 
Pro Ile Cys Lys Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu 
625                 630                 635                 640 
Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser 
                645                 650                 655     
Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro 
            660                 665                 670         
Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys 
        675                 680                 685             
Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly 
    690                 695                 700                 
Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu 
705                 710                 715                 720 
Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr 
                725                 730                 735     
Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp 
            740                 745                 750         
Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 63
<211> 766
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 63
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Gly Pro Pro Pro Pro Ile 
625                 630                 635                 640 
Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala 
                645                 650                 655     
Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn 
            660                 665                 670         
Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys 
        675                 680                 685             
Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile 
    690                 695                 700                 
Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu 
705                 710                 715                 720 
Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser 
                725                 730                 735     
His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr 
            740                 745                 750         
Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        755                 760                 765     

<210> 64
<211> 944
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 64
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Lys Ser Pro Pro Glu Ile 
625                 630                 635                 640 
Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu 
                645                 650                 655     
Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala 
            660                 665                 670         
Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile 
        675                 680                 685             
Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met 
    690                 695                 700                 
Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr 
705                 710                 715                 720 
Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile 
                725                 730                 735     
Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val 
            740                 745                 750         
Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
        755                 760                 765             
Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
    770                 775                 780                 
Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
785                 790                 795                 800 
Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
                805                 810                 815     
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
            820                 825                 830         
Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
        835                 840                 845             
Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
    850                 855                 860                 
Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
865                 870                 875                 880 
Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
                885                 890                 895     
Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
            900                 905                 910         
Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
        915                 920                 925             
Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    930                 935                 940                 



<210> 65
<211> 1005
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 65
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Ser Gln Pro Pro Gln Ile 
625                 630                 635                 640 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                645                 650                 655     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            660                 665                 670         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        675                 680                 685             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    690                 695                 700                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
705                 710                 715                 720 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                725                 730                 735     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            740                 745                 750         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        755                 760                 765             
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    770                 775                 780                 
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
785                 790                 795                 800 
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                805                 810                 815     
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            820                 825                 830         
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        835                 840                 845             
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    850                 855                 860                 
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
865                 870                 875                 880 
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                885                 890                 895     
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            900                 905                 910         
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        915                 920                 925             
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    930                 935                 940                 
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
945                 950                 955                 960 
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                965                 970                 975     
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            980                 985                 990         
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        995                 1000                1005

<210> 66
<211> 1064
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 66
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Pro Pro Pro Pro Gln Ile 
625                 630                 635                 640 
Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu 
                645                 650                 655     
Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu 
            660                 665                 670         
Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val 
        675                 680                 685             
Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile 
    690                 695                 700                 
Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu 
705                 710                 715                 720 
Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr 
                725                 730                 735     
Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu 
            740                 745                 750         
Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met 
        755                 760                 765             
Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu 
    770                 775                 780                 
Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys 
785                 790                 795                 800 
Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro 
                805                 810                 815     
Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys 
            820                 825                 830         
Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp 
        835                 840                 845             
Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro 
    850                 855                 860                 
Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala 
865                 870                 875                 880 
Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val 
                885                 890                 895     
Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val 
            900                 905                 910         
Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser 
        915                 920                 925             
Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
    930                 935                 940                 
Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
945                 950                 955                 960 
Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
                965                 970                 975     
Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
            980                 985                 990         
Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
        995                 1000                1005            
Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
    1010                1015                1020                
Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
1025                1030                1035                1040
Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly 
                1045                1050                1055    
Ser Gly His His His His His His 
            1060                

<210> 67
<211> 1122
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 67
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Lys Ser Ser Asn Leu Ile 
625                 630                 635                 640 
Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser 
                645                 650                 655     
Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val 
            660                 665                 670         
Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln 
        675                 680                 685             
Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met 
    690                 695                 700                 
Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys 
705                 710                 715                 720 
Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp 
                725                 730                 735     
Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser 
            740                 745                 750         
Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser 
        755                 760                 765             
Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly 
    770                 775                 780                 
Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys 
785                 790                 795                 800 
Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro 
                805                 810                 815     
Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr 
            820                 825                 830         
Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly 
        835                 840                 845             
Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser 
    850                 855                 860                 
Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile 
865                 870                 875                 880 
Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr 
                885                 890                 895     
Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr 
            900                 905                 910         
Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser 
        915                 920                 925             
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
    930                 935                 940                 
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
945                 950                 955                 960 
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                965                 970                 975     
Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            980                 985                 990         
Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        995                 1000                1005            
Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    1010                1015                1020                
Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
1025                1030                1035                1040
Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                1045                1050                1055    
Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
            1060                1065                1070        
Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        1075                1080                1085            
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    1090                1095                1100                
Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His 
1105                1110                1115                1120
His His 
        

<210> 68
<211> 1184
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 68
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Gly Asp Ile Pro Glu Leu 
625                 630                 635                 640 
Glu His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp 
                645                 650                 655     
Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg 
            660                 665                 670         
Ser Ile Thr Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val 
        675                 680                 685             
Ala Ile Asp Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu 
    690                 695                 700                 
Glu Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile 
705                 710                 715                 720 
Arg Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile 
                725                 730                 735     
Asn Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln 
            740                 745                 750         
Leu Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr 
        755                 760                 765             
Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu 
    770                 775                 780                 
Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg 
785                 790                 795                 800 
Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro 
                805                 810                 815     
Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu 
            820                 825                 830         
Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe 
        835                 840                 845             
Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser 
    850                 855                 860                 
Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile 
865                 870                 875                 880 
Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu 
                885                 890                 895     
Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala 
            900                 905                 910         
Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile 
        915                 920                 925             
Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met 
    930                 935                 940                 
Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr 
945                 950                 955                 960 
Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile 
                965                 970                 975     
Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val 
            980                 985                 990         
Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
        995                 1000                1005            
Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
    1010                1015                1020                
Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
1025                1030                1035                1040
Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
                1045                1050                1055    
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
            1060                1065                1070        
Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
        1075                1080                1085            
Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
    1090                1095                1100                
Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
1105                1110                1115                1120
Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
                1125                1130                1135    
Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
            1140                1145                1150        
Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
        1155                1160                1165            
Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    1170                1175                1180                



<210> 69
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 69
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Gly Ala Ser Gly Cys Gly Pro Pro Pro Glu Leu 
625                 630                 635                 640 
Leu Asn Gly Asn Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser 
                645                 650                 655     
Glu Val Val Glu Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro 
            660                 665                 670         
Asn Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys 
        675                 680                 685             
Ile Val Glu Glu Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly 
    690                 695                 700                 
Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu 
705                 710                 715                 720 
Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr 
                725                 730                 735     
Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp 
            740                 745                 750         
Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 70
<211> 827
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 70
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
    690                 695                 700                 
Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
705                 710                 715                 720 
Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
                725                 730                 735     
Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
            740                 745                 750         
Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
        755                 760                 765             
Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
    770                 775                 780                 
Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
785                 790                 795                 800 
Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
                805                 810                 815     
Arg Gly Gly Ser Gly His His His His His His 
            820                 825         

<210> 71
<211> 1005
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 71
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    690                 695                 700                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
705                 710                 715                 720 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                725                 730                 735     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            740                 745                 750         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        755                 760                 765             
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    770                 775                 780                 
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
785                 790                 795                 800 
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                805                 810                 815     
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            820                 825                 830         
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        835                 840                 845             
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    850                 855                 860                 
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
865                 870                 875                 880 
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                885                 890                 895     
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            900                 905                 910         
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        915                 920                 925             
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    930                 935                 940                 
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
945                 950                 955                 960 
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                965                 970                 975     
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            980                 985                 990         
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        995                 1000                1005

<210> 72
<211> 1066
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 72
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Ser Gln Pro Pro Gln Ile Glu His Gly 
    690                 695                 700                 
Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr 
705                 710                 715                 720 
Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn 
                725                 730                 735     
Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu 
            740                 745                 750         
Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala 
        755                 760                 765             
His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys 
    770                 775                 780                 
Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly 
785                 790                 795                 800 
Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser 
                805                 810                 815     
Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val 
            820                 825                 830         
Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys 
        835                 840                 845             
Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly 
    850                 855                 860                 
Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln 
865                 870                 875                 880 
Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu 
                885                 890                 895     
Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu 
            900                 905                 910         
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys 
        915                 920                 925             
Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
    930                 935                 940                 
Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
945                 950                 955                 960 
Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
                965                 970                 975     
Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
            980                 985                 990         
Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
        995                 1000                1005            
Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
    1010                1015                1020                
Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
1025                1030                1035                1040
Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                1045                1050                1055    
Gly Gly Ser Gly His His His His His His 
            1060                1065    

<210> 73
<211> 1125
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 73
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser 
    690                 695                 700                 
His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser 
705                 710                 715                 720 
Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr 
                725                 730                 735     
Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile 
            740                 745                 750         
Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser 
        755                 760                 765             
Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr 
    770                 775                 780                 
Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr 
785                 790                 795                 800 
Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys 
                805                 810                 815     
Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser 
            820                 825                 830         
Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly 
        835                 840                 845             
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His 
    850                 855                 860                 
Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu 
865                 870                 875                 880 
Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu 
                885                 890                 895     
Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser 
            900                 905                 910         
Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg 
        915                 920                 925             
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
    930                 935                 940                 
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
945                 950                 955                 960 
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
                965                 970                 975     
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
            980                 985                 990         
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
        995                 1000                1005            
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
    1010                1015                1020                
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
1025                1030                1035                1040
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
                1045                1050                1055    
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
            1060                1065                1070        
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
        1075                1080                1085            
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
    1090                1095                1100                
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
1105                1110                1115                1120
His His His His His 
                1125

<210> 74
<211> 1183
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 74
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu 
    690                 695                 700                 
Glu His Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg 
705                 710                 715                 720 
Tyr Arg Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn 
                725                 730                 735     
Gly Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu 
            740                 745                 750         
Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr 
        755                 760                 765             
Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn 
    770                 775                 780                 
Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp 
785                 790                 795                 800 
Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro 
                805                 810                 815     
Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser 
            820                 825                 830         
Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg 
        835                 840                 845             
Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser 
    850                 855                 860                 
Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser 
865                 870                 875                 880 
His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu 
                885                 890                 895     
Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile 
            900                 905                 910         
Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys 
        915                 920                 925             
Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly 
    930                 935                 940                 
Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys 
945                 950                 955                 960 
Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn 
                965                 970                 975     
Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn 
            980                 985                 990         
Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys 
        995                 1000                1005            
Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
    1010                1015                1020                
Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 
1025                1030                1035                1040
Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
                1045                1050                1055    
Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
            1060                1065                1070        
Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
        1075                1080                1085            
Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
    1090                1095                1100                
Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
1105                1110                1115                1120
Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
                1125                1130                1135    
Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
            1140                1145                1150        
Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
        1155                1160                1165            
Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His His His 
    1170                1175                1180            

<210> 75
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 75
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Gly Ala Ser Gly Cys Gly Asp Ile Pro Glu Leu Glu His Gly 
    690                 695                 700                 
Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu 
705                 710                 715                 720 
Phe Asn Cys Ser Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr 
                725                 730                 735     
Cys Ile His Gly Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp 
            740                 745                 750         
Lys Leu Lys Lys Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 76
<211> 889
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 76
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Gly Ala Ser Gly Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
        755                 760                 765             
Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
    770                 775                 780                 
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
785                 790                 795                 800 
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
                805                 810                 815     
Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
            820                 825                 830         
Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
        835                 840                 845             
Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
    850                 855                 860                 
Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly 
865                 870                 875                 880 
Gly Ser Gly His His His His His His 
                885                 

<210> 77
<211> 1067
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 77
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Gly Ala Ser Gly Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val 
        755                 760                 765             
Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys 
    770                 775                 780                 
Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu 
785                 790                 795                 800 
Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu 
                805                 810                 815     
Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp 
            820                 825                 830         
Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr 
        835                 840                 845             
Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr 
    850                 855                 860                 
Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val 
865                 870                 875                 880 
Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly 
                885                 890                 895     
Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp 
            900                 905                 910         
Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys 
        915                 920                 925             
Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
    930                 935                 940                 
Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
945                 950                 955                 960 
Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
                965                 970                 975     
Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
            980                 985                 990         
Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
        995                 1000                1005            
Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
    1010                1015                1020                
Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
1025                1030                1035                1040
Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
                1045                1050                1055    
Arg Gly Gly Ser Gly His His His His His His 
            1060                1065        

<210> 78
<211> 1128
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 78
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Gly Ala Ser Gly Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile 
        755                 760                 765             
Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu 
    770                 775                 780                 
Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr 
785                 790                 795                 800 
Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu 
                805                 810                 815     
Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met 
            820                 825                 830         
Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu 
        835                 840                 845             
Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys 
    850                 855                 860                 
Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro 
865                 870                 875                 880 
Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys 
                885                 890                 895     
Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp 
            900                 905                 910         
Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro 
        915                 920                 925             
Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala 
    930                 935                 940                 
Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val 
945                 950                 955                 960 
Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val 
                965                 970                 975     
Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser 
            980                 985                 990         
Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
        995                 1000                1005            
Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
    1010                1015                1020                
Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
1025                1030                1035                1040
Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
                1045                1050                1055    
Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
            1060                1065                1070        
Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
        1075                1080                1085            
Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
    1090                1095                1100                
Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly 
1105                1110                1115                1120
Ser Gly His His His His His His 
                1125            

<210> 79
<211> 1187
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 79
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Gly Ala Ser Gly Cys Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn 
        755                 760                 765             
Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys Val Ser Val Leu 
    770                 775                 780                 
Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys 
785                 790                 795                 800 
Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu Lys Ile Pro Cys 
                805                 810                 815     
Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser 
            820                 825                 830         
Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu 
        835                 840                 845             
Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly 
    850                 855                 860                 
Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro 
865                 870                 875                 880 
Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln 
                885                 890                 895     
Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp 
            900                 905                 910         
Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro 
        915                 920                 925             
Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala 
    930                 935                 940                 
Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val 
945                 950                 955                 960 
Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val 
                965                 970                 975     
Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr 
            980                 985                 990         
Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg 
        995                 1000                1005            
Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg 
    1010                1015                1020                
Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly 
1025                1030                1035                1040
Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly 
                1045                1050                1055    
Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
            1060                1065                1070        
Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
        1075                1080                1085            
Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
    1090                1095                1100                
Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
1105                1110                1115                1120
Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
                1125                1130                1135    
Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
            1140                1145                1150        
Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
        1155                1160                1165            
Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His 
    1170                1175                1180                
His His His 
1185        

<210> 80
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 80
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Gly Ala Ser Gly Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His 
        755                 760                 765             
Leu Lys Asn Lys Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg 
    770                 775                 780                 
Cys Arg Gly Lys Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg 
785                 790                 795                 800 
Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 81
<211> 947
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 81
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Gly Ala Ser Gly Cys Gly 
                805                 810                 815     
Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
            820                 825                 830         
Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
        835                 840                 845             
Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
    850                 855                 860                 
Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
865                 870                 875                 880 
Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
                885                 890                 895     
Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
            900                 905                 910         
Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
        915                 920                 925             
Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His 
    930                 935                 940                 
His His His 
945         

<210> 82
<211> 1125
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 82
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Gly Ala Ser Gly Cys Lys 
                805                 810                 815     
Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser 
            820                 825                 830         
Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly 
        835                 840                 845             
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His 
    850                 855                 860                 
Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu 
865                 870                 875                 880 
Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu 
                885                 890                 895     
Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser 
            900                 905                 910         
Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg 
        915                 920                 925             
Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
    930                 935                 940                 
Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
945                 950                 955                 960 
Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
                965                 970                 975     
Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
            980                 985                 990         
Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
        995                 1000                1005            
Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
    1010                1015                1020                
Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
1025                1030                1035                1040
Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
                1045                1050                1055    
Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
            1060                1065                1070        
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
        1075                1080                1085            
Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
    1090                1095                1100                
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His 
1105                1110                1115                1120
His His His His His 
                1125

<210> 83
<211> 1186
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 83
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Gly Ala Ser Gly Cys Ser 
                805                 810                 815     
Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser 
            820                 825                 830         
Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly 
        835                 840                 845             
Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys 
    850                 855                 860                 
Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro 
865                 870                 875                 880 
Glu Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr 
                885                 890                 895     
Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly 
            900                 905                 910         
Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser 
        915                 920                 925             
Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile 
    930                 935                 940                 
Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr 
945                 950                 955                 960 
Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr 
                965                 970                 975     
Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser 
            980                 985                 990         
Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln 
        995                 1000                1005            
Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser 
    1010                1015                1020                
Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
1025                1030                1035                1040
Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
                1045                1050                1055    
Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
            1060                1065                1070        
Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
        1075                1080                1085            
Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
    1090                1095                1100                
Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
1105                1110                1115                1120
Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
                1125                1130                1135    
Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
            1140                1145                1150        
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
        1155                1160                1165            
Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser Gly His His His His 
    1170                1175                1180                
His His 
1185    

<210> 84
<211> 1245
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 84
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Gly Ala Ser Gly Cys Pro 
                805                 810                 815     
Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn 
            820                 825                 830         
Tyr Arg Asp Gly Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu 
        835                 840                 845             
Ile Gln Glu Gly Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser 
    850                 855                 860                 
Ile Pro Leu Cys Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile 
865                 870                 875                 880 
Glu His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala 
                885                 890                 895     
His Gly Thr Lys Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser 
            900                 905                 910         
Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro 
        915                 920                 925             
Gln Cys Glu Gly Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly 
    930                 935                 940                 
Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr 
945                 950                 955                 960 
Tyr Lys Cys Phe Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys 
                965                 970                 975     
Cys Leu Gly Glu Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp 
            980                 985                 990         
Cys Leu Ser Leu Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys 
        995                 1000                1005            
Lys Asp Val Tyr Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr 
    1010                1015                1020                
Tyr Tyr Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg 
1025                1030                1035                1040
Trp Thr Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro 
                1045                1050                1055    
Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
            1060                1065                1070        
Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
        1075                1080                1085            
Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
    1090                1095                1100                
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
1105                1110                1115                1120
Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
                1125                1130                1135    
Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
            1140                1145                1150        
Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
        1155                1160                1165            
His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
    1170                1175                1180                
Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
1185                1190                1195                1200
Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
                1205                1210                1215    
Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
            1220                1225                1230        
Ala Lys Arg Gly Gly Ser Gly His His His His His His 
        1235                1240                1245

<210> 85
<211> 3699
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..3699
<223> /mol_type="unassigned ADN"
      /note="séquence FH optimisée"
      /organism="Sequence artificielle"

<400> 85
atgagactgc tggctaagat tatttgcctg atgctgtggg ctatttgcgt cgccgaagac       60

tgtaacgaac tgcctccaag aagaaacacc gaaatcctga cagggagttg gtcagaccag      120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga      180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc      240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc      300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg      360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt      420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc      480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc      540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag      600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca      660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc      720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct      780

tcctgcgagg aaaaatcttg tgacaacccc tacatcccta atggggatta ttccccactg      840

cgcatcaagc accgaactgg agacgagatt acctaccagt gcaggaatgg cttctacccc      900

gctacacgcg gcaacactgc aaagtgtact tctaccggat ggattcccgc tccccggtgc      960

acactgaaac cttgtgacta cccagatatt aagcacggag gcctgtacca tgagaatatg     1020

cggagaccat atttccccgt ggcagtcggc aagtactatt cctactattg cgatgaacac     1080

tttgagaccc ccagcggctc ctattgggac cacatccatt gcacacagga tgggtggtct     1140

cctgccgtgc catgcctgcg aaaatgttat ttcccttacc tggagaacgg ctacaaccag     1200

aattacgggc gcaaatttgt gcagggcaag agcatcgacg tggcttgcca tcccggctat     1260

gctctgccta aggcacagac cacagtgacc tgtatggaga atgggtggtc ccctacacca     1320

aggtgcatcc gcgtgaaaac ttgttctaag agcagcatcg acattgaaaa cgggttcatt     1380

tctgagagtc agtatacata cgccctgaaa gagaaggcta aataccagtg caagctggga     1440

tatgtgacag ccgacggcga aacttcaggg agcatcacct gcgggaaaga tggatggtcc     1500

gcccagccta cctgcatcaa gtcttgtgac attccagtgt ttatgaacgc tagaacaaag     1560

aacgatttca cttggttcaa gctgaatgac actctggatt acgaatgcca cgacggctat     1620

gagtccaata ccggatctac taccggcagt atcgtgtgcg gctacaacgg gtggagcgac     1680

ctgcccatct gctatgagcg ggaatgtgag ctgccaaaaa ttgatgtgca cctggtcccc     1740

gacagaaaga aagatcagta caaagtgggc gaggtcctga aattcagctg caagcccggg     1800

tttaccatcg tgggacctaa cagcgtccag tgttatcatt tcgggctgtc ccccgatctg     1860

cctatttgca aggagcaggt gcagagctgt ggaccacctc cagaactgct gaacggaaat     1920

gtgaaggaga aaacaaagga ggaatacggc cacagcgaag tggtcgagta ctattgcaat     1980

ccacggtttc tgatgaaagg ccccaacaag atccagtgcg tggacgggga gtggacaact     2040

ctgcccgtgt gcatcgtcga ggaatccacc tgtggcgata ttccagaact ggagcatggg     2100

tgggcacagc tgtcaagccc cccttactat tacggcgaca gcgtggaatt caactgctcc     2160

gagtctttta caatgatcgg acacagatcc atcacttgta ttcatggcgt gtggacccag     2220

ctgccacagt gcgtcgccat tgacaaactg aagaaatgca agtcctctaa tctgatcatt     2280

ctggaggaac acctgaagaa caagaaggaa ttcgatcata actctaatat caggtaccgc     2340

tgccgaggaa aggagggctg gattcacacc gtgtgcatta atgggaggtg ggaccccgaa     2400

gtcaactgct ctatggcaca gatccagctg tgcccaccac ctccacagat tcctaacagt     2460

cataatatga ccacaactct gaattacagg gacggcgaga aggtgtctgt cctgtgccag     2520

gaaaactatc tgatccagga gggagaggaa attacctgta aagatggccg ctggcagtca     2580

atccctctgt gcgtggaaaa gattccatgt agccagcccc ctcagatcga gcacggaaca     2640

attaatagtt cacggagctc ccaggagagt tacgctcatg gcaccaagct gtcatataca     2700

tgcgaagggg gattcagaat cagcgaggaa aacgagacca catgttacat gggcaaatgg     2760

tctagtccac cccagtgcga agggctgcct tgtaagagtc ctccagagat ttcacacgga     2820

gtggtcgcac atatgagtga ctcatatcag tacggcgagg aagtgacata caaatgcttc     2880

gagggctttg ggatcgacgg ccctgccatt gctaaatgtc tgggagaaaa gtggtcacac     2940

ccccctagct gcatcaagac tgactgtctg tcactgccca gctttgaaaa tgctattcct     3000

atgggggaga agaaagacgt gtacaaagca ggagagcagg tcacatatac ttgcgccaca     3060

tattacaaga tggacggcgc ttcaaacgtg acttgtatca atagccggtg gaccgggaga     3120

cctacatgca gggatactag ctgcgtgaac ccacccaccg tccagaatgc ctacatcgtg     3180

agccggcaga tgtctaagta tccaagtggc gaacgggtga gataccagtg ccgcagcccc     3240

tatgagatgt tcggcgacga ggaagtgatg tgcctgaacg ggaattggac cgagcctcca     3300

cagtgcaaag atagcaccgg gaagtgtgga ccccctccac ccatcgacaa cggcgatatt     3360

acttcatttc cactgagcgt gtacgcaccc gcctcaagcg tcgaatacca gtgccagaac     3420

ctgtatcagc tggagggaaa caagcgcatc acctgtcgaa acggccagtg gagtgagcct     3480

ccaaagtgcc tgcacccatg cgtgatctca cgggaaatta tggagaacta caatattgca     3540

ctgagatgga ctgccaaaca gaagctgtat agcaggaccg gagaatccgt ggagttcgtc     3600

tgcaagcgag gctaccggct gtcctctaga agccataccc tgaggactac ctgttgggac     3660

ggaaaactgg aataccccac ttgtgctaaa cgctgataa                            3699


<210> 86
<211> 12
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..12
<223> /mol_type="unassigned ADN"
      /note="linker"
      /organism="Sequence artificielle"

<400> 86
gccgctagcg cc                                                        12


<210> 87
<211> 54
<212> ADN
<213> Homo sapiens

<220> 
<221> source
<222> 1..54
<223> /mol_type="unassigned ADN"
      /organism="Homo sapiens"

<400> 87
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agca           54


<210> 88
<211> 54
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..54
<223> /mol_type="unassigned ADN"
      /note="séquence peptide signal"
      /organism="Sequence artificielle"

<400> 88
atgagactgc tggctaagat tatttgcctg atgctgtggg ctatttgcgt cgcc           54


<210> 89
<211> 54
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..54
<223> /mol_type="unassigned ADN"
      /note="séquence peptide signal"
      /organism="Sequence artificielle"

<400> 89
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgct           54


<210> 90
<211> 3699
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..3699
<223> /mol_type="unassigned ADN"
      /note="MD3"
      /organism="Sequence artificielle"

<400> 90
atgcgatggt cttggatttt tctgctgctg ctgtctatca cttctgctaa cgctgaagac       60

tgtaacgaac tgcctccaag aagaaacacc gaaatcctga cagggagttg gtcagaccag      120

acctaccccg agggaacaca ggcaatctat aaatgcagac ctgggtacag gagcctggga      180

aatgtgatta tggtctgtag gaagggagag tgggtggccc tgaacccact gcggaaatgc      240

cagaagagac catgtggaca ccccggcgac acacctttcg ggacttttac cctgacaggc      300

gggaacgtgt tcgaatatgg agtgaaggcc gtctacactt gcaatgaggg ctatcagctg      360

ctgggggaaa tcaactaccg cgagtgtgac actgatggct ggaccaatga tatccctatt      420

tgcgaagtgg tcaaatgtct gccagtgacc gcacccgaga acgggaagat cgtcagctcc      480

gccatggaac cagaccgaga gtaccacttc ggacaggctg tgcggtttgt ctgcaattcc      540

ggatataaga tcgagggcga tgaggaaatg cattgttctg acgatggatt ctggagtaag      600

gaaaaaccta agtgcgtgga gattagctgt aaatcccctg acgtgatcaa cggctctcca      660

attagtcaga aaatcatcta caaggagaat gaacgctttc agtataagtg caacatgggc      720

tatgaatact ctgagcgagg ggatgccgtg tgcaccgaga gtggatggcg acccctgcct      780

tcctgcgagg aaaaatcttg tgacaacccc tacatcccta atggggatta ttccccactg      840

cgcatcaagc accgaactgg agacgagatt acctaccagt gcaggaatgg cttctacccc      900

gctacacgcg gcaacactgc aaagtgtact tctaccggat ggattcccgc tccccggtgc      960

acactgaaac cttgtgacta cccagatatt aagcacggag gcctgtacca tgagaatatg     1020

cggagaccat atttccccgt ggcagtcggc aagtactatt cctactattg cgatgaacac     1080

tttgagaccc ccagcggctc ctattgggac cacatccatt gcacacagga tgggtggtct     1140

cctgccgtgc catgcctgcg aaaatgttat ttcccttacc tggagaacgg ctacaaccag     1200

aattacgggc gcaaatttgt gcagggcaag agcatcgacg tggcttgcca tcccggctat     1260

gctctgccta aggcacagac cacagtgacc tgtatggaga atgggtggtc ccctacacca     1320

aggtgcatcc gcgtgaaaac ttgttctaag agcagcatcg acattgaaaa cgggttcatt     1380

tctgagagtc agtatacata cgccctgaaa gagaaggcta aataccagtg caagctggga     1440

tatgtgacag ccgacggcga aacttcaggg agcatcacct gcgggaaaga tggatggtcc     1500

gcccagccta cctgcatcaa gtcttgtgac attccagtgt ttatgaacgc tagaacaaag     1560

aacgatttca cttggttcaa gctgaatgac actctggatt acgaatgcca cgacggctat     1620

gagtccaata ccggatctac taccggcagt atcgtgtgcg gctacaacgg gtggagcgac     1680

ctgcccatct gctatgagcg ggaatgtgag ctgccaaaaa ttgatgtgca cctggtcccc     1740

gacagaaaga aagatcagta caaagtgggc gaggtcctga aattcagctg caagcccggg     1800

tttaccatcg tgggacctaa cagcgtccag tgttatcatt tcgggctgtc ccccgatctg     1860

cctatttgca aggagcaggt gcagagctgt ggaccacctc cagaactgct gaacggaaat     1920

gtgaaggaga aaacaaagga ggaatacggc cacagcgaag tggtcgagta ctattgcaat     1980

ccacggtttc tgatgaaagg ccccaacaag atccagtgcg tggacgggga gtggacaact     2040

ctgcccgtgt gcatcgtcga ggaatccacc tgtggcgata ttccagaact ggagcatggg     2100

tgggcacagc tgtcaagccc cccttactat tacggcgaca gcgtggaatt caactgctcc     2160

gagtctttta caatgatcgg acacagatcc atcacttgta ttcatggcgt gtggacccag     2220

ctgccacagt gcgtcgccat tgacaaactg aagaaatgca agtcctctaa tctgatcatt     2280

ctggaggaac acctgaagaa caagaaggaa ttcgatcata actctaatat caggtaccgc     2340

tgccgaggaa aggagggctg gattcacacc gtgtgcatta atgggaggtg ggaccccgaa     2400

gtcaactgct ctatggcaca gatccagctg tgcccaccac ctccacagat tcctaacagt     2460

cataatatga ccacaactct gaattacagg gacggcgaga aggtgtctgt cctgtgccag     2520

gaaaactatc tgatccagga gggagaggaa attacctgta aagatggccg ctggcagtca     2580

atccctctgt gcgtggaaaa gattccatgt agccagcccc ctcagatcga gcacggaaca     2640

attaatagtt cacggagctc ccaggagagt tacgctcatg gcaccaagct gtcatataca     2700

tgcgaagggg gattcagaat cagcgaggaa aacgagacca catgttacat gggcaaatgg     2760

tctagtccac cccagtgcga agggctgcct tgtaagagtc ctccagagat ttcacacgga     2820

gtggtcgcac atatgagtga ctcatatcag tacggcgagg aagtgacata caaatgcttc     2880

gagggctttg ggatcgacgg ccctgccatt gctaaatgtc tgggagaaaa gtggtcacac     2940

ccccctagct gcatcaagac tgactgtctg tcactgccca gctttgaaaa tgctattcct     3000

atgggggaga agaaagacgt gtacaaagca ggagagcagg tcacatatac ttgcgccaca     3060

tattacaaga tggacggcgc ttcaaacgtg acttgtatca atagccggtg gaccgggaga     3120

cctacatgca gggatactag ctgcgtgaac ccacccaccg tccagaatgc ctacatcgtg     3180

agccggcaga tgtctaagta tccaagtggc gaacgggtga gataccagtg ccgcagcccc     3240

tatgagatgt tcggcgacga ggaagtgatg tgcctgaacg ggaattggac cgagcctcca     3300

cagtgcaaag atagcaccgg gaagtgtgga ccccctccac ccatcgacaa cggcgatatt     3360

acttcatttc cactgagcgt gtacgcaccc gcctcaagcg tcgaatacca gtgccagaac     3420

ctgtatcagc tggagggaaa caagcgcatc acctgtcgaa acggccagtg gagtgagcct     3480

ccaaagtgcc tgcacccatg cgtgatctca cgggaaatta tggagaacta caatattgca     3540

ctgagatgga ctgccaaaca gaagctgtat agcaggaccg gagaatccgt ggagttcgtc     3600

tgcaagcgag gctaccggct gtcctctaga agccataccc tgaggactac ctgttgggac     3660

ggaaaactgg aataccccac ttgtgctaaa cgctgataa                            3699


<210> 91
<211> 21
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 91
ctctagcggc cgcgcgccac c                                              21


<210> 92
<211> 74
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..74
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 92
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc agatttttcc     60

tcgcaggaag gcag                                                       74


<210> 93
<211> 73
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..73
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 93
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc agttttcacg     60

cggatgcacc ttg                                                        73


<210> 94
<211> 72
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..72
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 94
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc agacttgatg     60

caggtaggct gg                                                         72


<210> 95
<211> 74
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..74
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 95
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc ttcccgctca     60

tagcagatgg gcag                                                       74


<210> 96
<211> 76
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..76
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 96
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc gctctgcacc     60

tgctccttgc aaatag                                                     76


<210> 97
<211> 72
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..72
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 97
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc ggtggattcc     60

tcgacgatgc ac                                                         72


<210> 98
<211> 74
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..74
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 98
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc tttcttcagt     60

ttgtcaatgg cgac                                                       74


<210> 99
<211> 75
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..75
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 99
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagcgcc cagctggatc     60

tgtgccatag agcag                                                      75


<210> 100
<211> 47
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..47
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 100
ctctaggatc cttatcaatg gtggtgatgg tggtggctgc cgctagc                   47


<210> 101
<211> 42
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..42
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 101
ctgccttcct gcgaggaaaa atctggcgct agcggcagcc ac                        42


<210> 102
<211> 41
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..41
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 102
caaggtgcat ccgcgtgaaa actggcgcta gcggcagcca c                         41


<210> 103
<211> 40
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..40
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 103
ccagcctacc tgcatcaagt ctggcgctag cggcagccac                           40


<210> 104
<211> 42
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..42
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 104
ctgcccatct gctatgagcg ggaaggcgct agcggcagcc ac                        42


<210> 105
<211> 43
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..43
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 105
tatttgcaag gagcaggtgc agagcggcgc tagcggcagc cac                       43


<210> 106
<211> 40
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..40
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 106
gtgcatcgtc gaggaatcca ccggcgctag cggcagccac                           40


<210> 107
<211> 42
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..42
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 107
gtcgccattg acaaactgaa gaaaggcgct agcggcagcc ac                        42


<210> 108
<211> 43
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..43
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 108
ctgctctatg gcacagatcc agctgggcgc tagcggcagc cac                       43


<210> 109
<211> 23
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 109
ccattgacgt caatgggagt ttg                                            23


<210> 110
<211> 20
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 110
tgtcacactc gcggtagttg                                                20


<210> 111
<211> 22
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 111
ttcactgcat tctagttgtg gt                                             22


<210> 112
<211> 105
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..105
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 112
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtgga ccccctccac ccatc                    105


<210> 113
<211> 110
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..110
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 113
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtaag agtcctccag agatttcaca               110


<210> 114
<211> 105
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..105
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 114
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtagc cagccccctc agatc                    105


<210> 115
<211> 106
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..106
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 115
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgccca ccacctccac agattc                   106


<210> 116
<211> 109
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..109
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 116
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgcaag tcctctaatc tgatcattc                109


<210> 117
<211> 106
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..106
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 117
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtggc gatattccag aactgg                   106


<210> 118
<211> 106
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..106
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 118
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtgga ccacctccag aactgc                   106


<210> 119
<211> 106
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..106
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 119
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtgag ctgccaaaaa ttgatg                   106


<210> 120
<211> 109
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..109
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 120
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgtgac attccagtgt ttatgaacg                109


<210> 121
<211> 109
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..109
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 121
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acgctgctag cggctgttct aagagcagca tcgacattg                109


<210> 122
<211> 74
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..74
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 122
gagtaggatc cttatcaatg gtggtgatgg tggtggccgc ttccgcctct cttagcacaa     60

gtagggtatt ccag                                                       74


<210> 123
<211> 45
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..45
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 123
gagtaggatc cttatcaatg gtggtgatgg tggtggccgc ttccg                     45


<210> 124
<211> 45
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..45
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 124
ctggaatacc ctacttgtgc taagagaggc ggaagcggcc accac                     45


<210> 125
<211> 35
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..35
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 125
ctctagcggc cgcgcgccac catgcgatgg tcttg                                35


<210> 126
<211> 53
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..53
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 126
cgttagcaga agtgatagac agcagcagca gaaaaatcca agaccatcgc atg            53


<210> 127
<211> 73
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..73
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 127
ctctagcggc cgcgcgccac catgcgatgg tcttggattt ttctgctgct gctgtctatc     60

acttctgcta acg                                                        73


<210> 128
<211> 47
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..47
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 128
gatgggtgga gggggtccac agccgctagc agcgttagca gaagtga                   47


<210> 129
<211> 52
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..52
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 129
tgtgaaatct ctggaggact cttacagccg ctagcagcgt tagcagaagt ga             52


<210> 130
<211> 47
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..47
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 130
gatctgaggg ggctggctac agccgctagc agcgttagca gaagtga                   47


<210> 131
<211> 48
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..48
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 131
gaatctgtgg aggtggtggg cagccgctag cagcgttagc agaagtga                  48


<210> 132
<211> 51
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..51
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 132
gaatgatcag attagaggac ttgcagccgc tagcagcgtt agcagaagtg a              51


<210> 133
<211> 48
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..48
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 133
ccagttctgg aatatcgcca cagccgctag cagcgttagc agaagtga                  48


<210> 134
<211> 48
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..48
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 134
gcagttctgg aggtggtcca cagccgctag cagcgttagc agaagtga                  48


<210> 135
<211> 48
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..48
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 135
catcaatttt tggcagctca cagccgctag cagcgttagc agaagtga                  48


<210> 136
<211> 51
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..51
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 136
cgttcataaa cactggaatg tcacagccgc tagcagcgtt agcagaagtg a              51


<210> 137
<211> 51
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..51
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 137
caatgtcgat gctgctctta gaacagccgc tagcagcgtt agcagaagtg a              51


<210> 138
<211> 40
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..40
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 138
tggtgatgct cagcagcagc aggaagatcc agctccatcg                           40


<210> 139
<211> 24
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 139
ggattcacac cgtgtgcatt aatg                                           24


<210> 140
<211> 21
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 140
agggaaacaa gcgcatcacc t                                              21


<210> 141
<211> 20
<212> ADN
<213> Sequence artificielle

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned ADN"
      /note="amorce"
      /organism="Sequence artificielle"

<400> 141
cagatggctg gcaactagaa                                                20


<210> 142
<211> 600
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 142
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ser Ser Gly Lys Glu 
            260                 265                 270         
Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val 
        275                 280                 285             
Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr 
    290                 295                 300                 
Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys 
305                 310                 315                 320 
Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser 
                325                 330                 335     
Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser 
            340                 345                 350         
Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu 
        355                 360                 365             
Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val 
    370                 375                 380                 
Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys 
385                 390                 395                 400 
Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys 
                405                 410                 415     
Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu 
            420                 425                 430         
Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val 
        435                 440                 445             
Asn Cys Ser Met Ala Gln Ile Gln Leu Gly Ser Ser Gly Lys Asp Ser 
    450                 455                 460                 
Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
465                 470                 475                 480 
Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
                485                 490                 495     
Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
            500                 505                 510         
Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
        515                 520                 525             
Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
    530                 535                 540                 
Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
545                 550                 555                 560 
Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
                565                 570                 575     
Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly 
            580                 585                 590         
Ser Gly His His His His His His 
        595                 600 

<210> 143
<211> 4
<212> PRT
<213> Homo sapiens


<400> 143
Gln Lys Arg Pro 
1               

<210> 144
<211> 4
<212> PRT
<213> Homo sapiens


<400> 144
Glu Val Val Lys 
1               

<210> 145
<211> 4
<212> PRT
<213> Homo sapiens


<400> 145
Val Glu Ile Ser 
1               

<210> 146
<211> 4
<212> PRT
<213> Homo sapiens


<400> 146
Glu Glu Lys Ser 
1               

<210> 147
<211> 4
<212> PRT
<213> Homo sapiens


<400> 147
Thr Leu Lys Pro 
1               

<210> 148
<211> 5
<212> PRT
<213> Homo sapiens


<400> 148
Ile Arg Val Lys Thr 
1               5   

<210> 149
<211> 4
<212> PRT
<213> Homo sapiens


<400> 149
Tyr Glu Arg Glu 
1               

<210> 150
<211> 6
<212> PRT
<213> Homo sapiens


<400> 150
Lys Glu Gln Val Gln Ser 
1               5       

<210> 151
<211> 6
<212> PRT
<213> Homo sapiens


<400> 151
Ile Val Glu Glu Ser Thr 
1               5       

<210> 152
<211> 8
<212> PRT
<213> Homo sapiens


<400> 152
Val Ala Ile Asp Lys Leu Lys Lys 
1               5               

<210> 153
<211> 7
<212> PRT
<213> Homo sapiens


<400> 153
Ser Met Ala Gln Ile Gln Leu 
1               5           

<210> 154
<211> 5
<212> PRT
<213> Homo sapiens


<400> 154
Val Glu Lys Ile Pro 
1               5   

<210> 155
<211> 4
<212> PRT
<213> Homo sapiens


<400> 155
Glu Gly Leu Pro 
1               

<210> 156
<211> 4
<212> PRT
<213> Homo sapiens


<400> 156
Ile Lys Thr Asp 
1               

<210> 157
<211> 4
<212> PRT
<213> Homo sapiens


<400> 157
Arg Asp Thr Ser 
1               

<210> 158
<211> 6
<212> PRT
<213> Homo sapiens


<400> 158
Lys Asp Ser Thr Gly Lys 
1               5       

<210> 159
<211> 647
<212> PRT
<213> Sequence artificielle

<220> 
<223> fragment FH

<400> 159
Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      
Asn Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Gly Ala Ser Gly Leu Arg 
            260                 265                 270         
Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
        275                 280                 285             
Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
    290                 295                 300                 
Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
305                 310                 315                 320 
Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Gly Ala Ser Gly 
                325                 330                 335     
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
            340                 345                 350         
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
        355                 360                 365             
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
    370                 375                 380                 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
385                 390                 395                 400 
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
                405                 410                 415     
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
            420                 425                 430         
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
        435                 440                 445             
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
    450                 455                 460                 
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
465                 470                 475                 480 
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
                485                 490                 495     
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
            500                 505                 510         
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
        515                 520                 525             
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
    530                 535                 540                 
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
545                 550                 555                 560 
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
                565                 570                 575     
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
            580                 585                 590         
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
        595                 600                 605             
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
    610                 615                 620                 
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Ser 
625                 630                 635                 640 
Gly His His His His His His 
                645         

