                         SEQUENCE LISTING

<110>  INSERM
 
<120>  CD300A RECEPTORS AS VIRUS ENTRY COFACTORS

<130>  BEX 14P0613

<150>  EP 13306820.5
<151>  2013-12-20

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  2
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  2
cggggaagtg agagtcgggg atcagtcctg caagctacgg agtcactaca gggagaggtc       60

tcatcactag aaatagccga agaacctgca gcctcaacca gcgttaagga ggacgtgccg      120

tttctaggga gtcttagtcg gggctcacca gcttcctgca ttttctgacc ggctccagga      180

atagaaccaa aagaagctga acaaggaagc agcgcggcac caagaaaagc agaagtcggg      240

gccttggagg cgtgactttc ccctcgggtc caggtagggc ctggagctgc tgcaagtgcc      300

gcctgtgctg gggaagggac catgtggctg ccttgggctc tgttgcttct ctgggtccca      360

ggatgttttg ctctgagcaa atgcaggacc gtggcgggcc ccgtgggggg atccctgagt      420

gtgcagtgtc cctatgagaa ggaacacagg accctcaaca aatactggtg cagaccacca      480

cagattttcc tatgtgacaa gattgtggag accaaagggt cagcaggaaa aaggaacggc      540

cgagtgtcca tcagggacag tcctgcaaac ctcagcttca cagtgaccct ggagaatctc      600

acagaggagg atgcaggcac ctactggtgt ggggtggata caccatggct ccgagacttt      660

catgatcccg ttgtcgaggt tgaggtgtcc gtgttcccgg catcaacgtc aatgacacct      720

gcaagtatca ctgcggccaa gacctcaaca atcacaactg catttccacc tgtatcatcc      780

actaccctgt ttgcagtggg tgccacccac agtgccagca tccaggagga aactgaggag      840

gtggtgaact cacagctccc gctgctcctc tccctgctgg cattgttgct gcttctgttg      900

gtgggggcct ccctgctagc ctggaggatg tttcagaaat ggatcaaagc tggtgaccat      960

tcagagctgt cccagaaccc caagcaggct gccacgcaga gtgagctgca ctacgcaaat     1020

ctggagctgc tgatgtggcc tctgcaggaa aagccagcac caccaaggga ggtggaggtg     1080

gaatacagca ctgtggcctc ccccagggaa gaacttcact atgcctcggt ggtgtttgat     1140

tctaacacca acaggatagc tgctcagagg cctcgggagg aggaaccaga ttcagattac     1200

agtgtgataa ggaagacata ggcttttgtc ctgcctcgcc atcggagctc tcatgggccc     1260

caggaagtcc agggacagct cccttatacc tggcccacgt ccttctcagc ctgccctcga     1320

caacagtgac caacagacag gcagctgggt ttcccaggcc atccctctgt tgccatcagc     1380

ttgattggct tccccgaggg ccagcagggc tgggggctcc ggagagcagc aggaagcact     1440

cccagccacc agtgcctgtc acctctttcc cctttgcccc tgcttcatcc cagctctgtg     1500

tgtggaggac aaagcttctt cctgcgtggc tccaggaaaa gatgtggctc acgtaggtgg     1560

cacctgccaa tagctttgtc aatcacagcc ccataggaac gtctggaatt gcttgggagt     1620

tggggagaac tgtcaagaag agtgaagaga gtgccaaagc ggagatctgt tcacctgggg     1680

gccatggagg ggggacccac taaagatcaa gatcaaagat tctccccatc tcacagacaa     1740

ggaaactgag gccagaggga ggagagaatt gctcatggct ccagaactgg tggcaagttt     1800

ctctggactc ttaggtttat ttttaatatg aaatataaaa acagtttcaa atatcttatt     1860

gagggagaag taaaaactta tttaaacaat gcc                                  1893


<210>  3
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  4
<211>  1624
<212>  DNA
<213>  Homo sapiens

<400>  4
gttgcttgga tcagtctagg tgcagctgcc ggatccttca gcgtctgcat ctcggcgtcg       60

ccccgcgtac cgtcgcccgg ctctccgccg ctctcccggg gtttcggggc acttgggtcc      120

cacagtctgg tcctgcttca ccttcccctg acctgagtag tcgccatggc acaggttctc      180

agaggcactg tgactgactt ccctggattt gatgagcggg ctgatgcaga aactcttcgg      240

aaggctatga aaggcttggg cacagatgag gagagcatcc tgactctgtt gacatcccga      300

agtaatgctc agcgccagga aatctctgca gcttttaaga ctctgtttgg cagggatctt      360

ctggatgacc tgaaatcaga actaactgga aaatttgaaa aattaattgt ggctctgatg      420

aaaccctctc ggctttatga tgcttatgaa ctgaaacatg ccttgaaggg agctggaaca      480

aatgaaaaag tactgacaga aattattgct tcaaggacac ctgaagaact gagagccatc      540

aaacaagttt atgaagaaga atatggctca agcctggaag atgacgtggt gggggacact      600

tcagggtact accagcggat gttggtggtt ctccttcagg ctaacagaga ccctgatgct      660

ggaattgatg aagctcaagt tgaacaagat gctcaggctt tatttcaggc tggagaactt      720

aaatggggga cagatgaaga aaagtttatc accatctttg gaacacgaag tgtgtctcat      780

ttgagaaagg tgtttgacaa gtacatgact atatcaggat ttcaaattga ggaaaccatt      840

gaccgcgaga cttctggcaa tttagagcaa ctactccttg ctgttgtgaa atctattcga      900

agtatacctg cctaccttgc agagaccctc tattatgcta tgaagggagc tgggacagat      960

gatcataccc tcatcagagt catggtttcc aggagtgaga ttgatctgtt taacatcagg     1020

aaggagttta ggaagaattt tgccacctct ctttattcca tgattaaggg agatacatct     1080

ggggactata agaaagctct tctgctgctc tgtggagaag atgactaacg tgtcacgggg     1140

aagagctccc tgctgtgtgc ctgcaccacc ccactgcctt ccttcagcac ctttagctgc     1200

atttgtatgc cagtgcttaa cacattgcct tattcatact agcatgctca tgaccaacac     1260

atacacgtca tagaagaaaa tagtggtgct tctttctgat ctctagtgga gatctctttg     1320

actgctgtag tactaaagtg tacttaatgt tactaagttt aatgcctggc cattttccat     1380

ttatatatat tttttaagag gctagagtgc ttttagcctt ttttaaaaac tccatttata     1440

ttacatttgt aaccatgata ctttaatcag aagcttagcc ttgaaattgt gaactcttgg     1500

aaatgttatt agtgaagttc gcaactaaac taaacctgta aaattatgat gattgtattc     1560

aaaagattaa tgaaaaataa acatttctgt ccccctgaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaa                                                                  1624


<210>  5
<211>  19
<212>  PRT
<213>  Streptomyces griseoverticillatus

<400>  5

Cys Lys Gln Ser Cys Ser Phe Gly Pro Phe Thr Phe Val Cys Asp Gly 
1               5                   10                  15      


Asn Thr Lys 
            


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif

<400>  6

Trp Leu Arg Asp 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif

<400>  7

Trp Ser Arg Asp 
1               


<210>  8
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu Ser Val 
1               5                   10                  15      


Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr Trp Cys 
            20                  25                  30          


Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr Lys Gly 
        35                  40                  45              


Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser Pro Ala 
    50                  55                  60                  


Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu Asp Ala 
65                  70                  75                  80  


Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Asp Phe His 
                85                  90                  95      


Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser Thr Ser 
            100                 105                 110         


Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile Thr Thr 
        115                 120                 125             


Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly Ala Thr 
    130                 135                 140                 


His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn Ser Gln 
145                 150                 155                 160 


Leu Pro 
        


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Thr Pro Trp Leu Arg Asp Phe His Asp 
1               5                   10  


<210>  10
<211>  19
<212>  PRT
<213>  Streptomyces sp. R2075

<400>  10

Cys Arg Gln Ser Cys Ser Phe Gly Pro Leu Thr Phe Val Cys Asp Gly 
1               5                   10                  15      


Asn Thr Lys 
            


<210>  11
<211>  19
<212>  PRT
<213>  Streptomyces griseoluteus

<400>  11

Cys Ala Asn Ser Cys Ser Tyr Gly Pro Leu Thr Trp Ser Cys Asp Gly 
1               5                   10                  15      


Asn Thr Lys 
            


<210>  12
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtggctgc cttgggctct gttgcttctc tgggtcccag gatgttttgc tctgagcaaa       60

tgcaggaccg tggcgggccc cgtgggggga tccctgagtg tgcagtgtcc ctatgagaag      120

gaacacagga ccctcaacaa atactggtgc agaccaccac agattttcct atgtgacaag      180

attgtggaga ccaaagggtc agcaggaaaa aggaacggcc gagtgtccat cagggacagt      240

cctgcaaacc tcagcttcac agtgaccctg gagaatctca cagaggagga tgcaggcacc      300

tactggtgtg gggtggatac accatggctc cgagactttc atgatcccgt tgtcgaggtt      360

gaggtgtccg tgttcccggc atcaacgtca atgacacctg caagtatcac tgcggccaag      420

acctcaacaa tcacaactgc atttccacct gtatcatcca ctaccctgtt tgcagtgggt      480

gccacccaca gtgccagcat ccaggaggaa actgaggagg tggtgaactc acagctcccg      540

ctgctcctct ccctgctggc attgttgctg cttctgttgg tgggggcctc cctgctagcc      600

tggaggatgt ttcagaaatg gatcaaagct ggtgaccatt cagagctgtc ccagaacccc      660

aagcaggctg ccacgcagag tgagctgcac tacgcaaatc tggagctgct gatgtggcct      720

ctgcaggaaa agccagcacc accaagggag gtggaggtgg aatacagcac tgtggcctcc      780

cccagggaag aacttcacta tgcctcggtg gtgtttgatt ctaacaccaa caggatagct      840

gctcagaggc ctcgggagga ggaaccagat tcagattaca gtgtgataag gaagacatag      900


<210>  13
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant

<400>  13

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Ala Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Ala Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  14
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant

<400>  14

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Ala Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  15
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant

<400>  15

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Ala 
            100                 105                 110         


Phe His Ala Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  16
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant

<400>  16

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Ala Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  17
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Asn Gly Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe 
1               5                   10                  15      


Thr Val Thr Leu Glu Asn Leu Thr Glu Glu Asp Ala Gly Thr Tyr Trp 
            20                  25                  30          


Cys Gly Val Asp Thr Pro Trp Leu Arg Asp Phe His Asp Pro Val Val 
        35                  40                  45              


Glu Val Glu 
    50      


<210>  18
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Ser Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asp Arg Thr Phe 
1               5                   10                  15      


Thr Val Thr Met Glu Gly Leu Arg Arg Asp Asp Ala Asp Val Tyr Trp 
            20                  25                  30          


Cys Gly Ile Glu Arg Arg Gly Pro Asp Leu Gly 
        35                  40              


<210>  19
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Asn Gly Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe 
1               5                   10                  15      


Thr Val Thr Leu Glu Asn Leu Thr Glu Glu Asp Ala Gly Thr Tyr Trp 
            20                  25                  30          


Cys Gly Val Asp Thr Pro Trp Leu Arg Asp Phe His Asp Pro Ile Val 
        35                  40                  45              


Glu Val Glu 
    50      


<210>  20
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Lys Asn Arg Val Ser Ile Arg Asp Asn Gln Lys Asn His Val Phe 
1               5                   10                  15      


Thr Val Thr Met Glu Asn Leu Lys Arg Asp Asp Ala Asp Ser Tyr Trp 
            20                  25                  30          


Cys Gly Thr Glu Arg Pro Gly Ile Asp Leu Gly Val Lys Val Gln 
        35                  40                  45          


<210>  21
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Asn Gly Arg Val Ser Ile Arg Asp His Pro Glu Ala Leu Ala Phe 
1               5                   10                  15      


Thr Val Thr Met Gln Asn Leu Asn Glu Asp Asp Ala Gly Ser Tyr Trp 
            20                  25                  30          


Cys Lys Ile Gln Thr Val Trp Val Leu Asp Ser Trp Ser Arg Asp Pro 
        35                  40                  45              


Ser Asp Leu Val Arg 
    50              


<210>  22
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Arg Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe 
1               5                   10                  15      


Thr Val Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp 
            20                  25                  30          


Cys Gly Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln 
        35                  40                  45          


