                         SEQUENCE LISTING

<110>  Technical University of Denmark
 
<120>  Stereo-specific biosynthesis of (13R) manoyl oxide

<130>  P3406EP00

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  773
<212>  PRT
<213>  Unknown

<220>
<223>  TPS2 from Coleus forskohlii


<220>
<221>  CfTPS2
<222>  (1)..(773)
<223>  Coleus forskohlii TPS2

<400>  1

Met Lys Met Leu Met Ile Lys Ser Gln Phe Arg Val His Ser Ile Val 
1               5                   10                  15      


Ser Ala Trp Ala Asn Asn Ser Asn Lys Arg Gln Ser Leu Gly His Gln 
            20                  25                  30          


Ile Arg Arg Lys Gln Arg Ser Gln Val Thr Glu Cys Arg Val Ala Ser 
        35                  40                  45              


Leu Asp Ala Leu Asn Gly Ile Gln Lys Val Gly Pro Ala Thr Ile Gly 
    50                  55                  60                  


Thr Pro Glu Glu Glu Asn Lys Lys Ile Glu Asp Ser Ile Glu Tyr Val 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Thr Met Gly Asp Gly Arg Ile Ser Val Ser Pro 
                85                  90                  95      


Tyr Asp Thr Ala Ile Val Ala Leu Ile Lys Asp Leu Glu Gly Gly Asp 
            100                 105                 110         


Gly Pro Glu Phe Pro Ser Cys Leu Glu Trp Ile Ala Gln Asn Gln Leu 
        115                 120                 125             


Ala Asp Gly Ser Trp Gly Asp His Phe Phe Cys Ile Tyr Asp Arg Val 
    130                 135                 140                 


Val Asn Thr Ala Ala Cys Val Val Ala Leu Lys Ser Trp Asn Val His 
145                 150                 155                 160 


Ala Asp Lys Ile Glu Lys Gly Ala Val Tyr Leu Lys Glu Asn Val His 
                165                 170                 175     


Lys Leu Lys Asp Gly Lys Ile Glu His Met Pro Ala Gly Phe Glu Phe 
            180                 185                 190         


Val Val Pro Ala Thr Leu Glu Arg Ala Lys Ala Leu Gly Ile Lys Gly 
        195                 200                 205             


Leu Pro Tyr Asp Asp Pro Phe Ile Arg Glu Ile Tyr Ser Ala Lys Gln 
    210                 215                 220                 


Thr Arg Leu Thr Lys Ile Pro Lys Gly Met Ile Tyr Glu Ser Pro Thr 
225                 230                 235                 240 


Ser Leu Leu Tyr Ser Leu Asp Gly Leu Glu Gly Leu Glu Trp Asp Lys 
                245                 250                 255     


Ile Leu Lys Leu Gln Ser Ala Asp Gly Ser Phe Ile Thr Ser Val Ser 
            260                 265                 270         


Ser Thr Ala Phe Val Phe Met His Thr Asn Asp Leu Lys Cys His Ala 
        275                 280                 285             


Phe Ile Lys Asn Ala Leu Thr Asn Cys Asn Gly Gly Val Pro His Thr 
    290                 295                 300                 


Tyr Pro Val Asp Ile Phe Ala Arg Leu Trp Ala Val Asp Arg Leu Gln 
305                 310                 315                 320 


Arg Leu Gly Ile Ser Arg Phe Phe Glu Pro Glu Ile Lys Tyr Leu Met 
                325                 330                 335     


Asp His Ile Asn Asn Val Trp Arg Glu Lys Gly Val Phe Ser Ser Arg 
            340                 345                 350         


His Ser Gln Phe Ala Asp Ile Asp Asp Thr Ser Met Gly Ile Arg Leu 
        355                 360                 365             


Leu Lys Met His Gly Tyr Asn Val Asn Pro Asn Ala Leu Glu His Phe 
    370                 375                 380                 


Lys Gln Lys Asp Gly Lys Phe Thr Cys Tyr Ala Asp Gln His Ile Glu 
385                 390                 395                 400 


Ser Pro Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe 
                405                 410                 415     


Pro Gly Glu Glu Ile Leu Gln Gln Ala Leu Gln Phe Ala Tyr Asn Phe 
            420                 425                 430         


Leu His Glu Asn Leu Ala Ser Asn His Phe Gln Glu Lys Trp Val Ile 
        435                 440                 445             


Ser Asp His Leu Ile Asp Glu Val Arg Ile Gly Leu Lys Met Pro Trp 
    450                 455                 460                 


Tyr Ala Thr Leu Pro Arg Val Glu Ala Ser Tyr Tyr Leu Gln His Tyr 
465                 470                 475                 480 


Gly Gly Ser Ser Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro 
                485                 490                 495     


Glu Ile Ser Asn Asp Thr Tyr Lys Ile Leu Ala Gln Leu Asp Phe Asn 
            500                 505                 510         


Lys Cys Gln Ala Gln His Gln Leu Glu Trp Met Ser Met Lys Glu Trp 
        515                 520                 525             


Tyr Gln Ser Asn Asn Val Lys Glu Phe Gly Ile Ser Lys Lys Glu Leu 
    530                 535                 540                 


Leu Leu Ala Tyr Phe Leu Ala Ala Ala Thr Met Phe Glu Pro Glu Arg 
545                 550                 555                 560 


Thr Gln Glu Arg Ile Met Trp Ala Lys Thr Gln Val Val Ser Arg Met 
                565                 570                 575     


Ile Thr Ser Phe Leu Asn Lys Glu Asn Thr Met Ser Phe Asp Leu Lys 
            580                 585                 590         


Ile Ala Leu Leu Thr Gln Pro Gln His Gln Ile Asn Gly Ser Glu Met 
        595                 600                 605             


Lys Asn Gly Leu Ala Gln Thr Leu Pro Ala Ala Phe Arg Gln Leu Leu 
    610                 615                 620                 


Lys Glu Phe Asp Lys Tyr Thr Arg His Gln Leu Arg Asn Thr Trp Asn 
625                 630                 635                 640 


Lys Trp Leu Met Lys Leu Lys Gln Gly Asp Asp Asn Gly Gly Ala Asp 
                645                 650                 655     


Ala Glu Leu Leu Ala Asn Thr Leu Asn Ile Cys Ala Gly His Asn Glu 
            660                 665                 670         


Asp Ile Leu Ser His Tyr Glu Tyr Thr Ala Leu Ser Ser Leu Thr Asn 
        675                 680                 685             


Lys Ile Cys Gln Arg Leu Ser Gln Ile Gln Asp Lys Lys Met Leu Glu 
    690                 695                 700                 


Ile Glu Glu Gly Ser Ile Lys Asp Lys Glu Met Glu Leu Glu Ile Gln 
705                 710                 715                 720 


Thr Leu Val Lys Leu Val Leu Gln Glu Thr Ser Gly Gly Ile Asp Arg 
                725                 730                 735     


Asn Ile Lys Gln Thr Phe Leu Ser Val Phe Lys Thr Phe Tyr Tyr Arg 
            740                 745                 750         


Ala Tyr His Asp Ala Lys Thr Ile Asp Ala His Ile Phe Gln Val Leu 
        755                 760                 765             


Phe Glu Pro Val Val 
    770             


<210>  2
<211>  785
<212>  PRT
<213>  Salvia sclarea


<220>
<221>  SsLPPS
<222>  (1)..(785)

<400>  2

Met Thr Ser Val Asn Leu Ser Arg Ala Pro Ala Ala Ile Thr Arg Arg 
1               5                   10                  15      


Arg Leu Gln Leu Gln Pro Glu Phe His Ala Glu Cys Ser Trp Leu Lys 
            20                  25                  30          


Ser Ser Ser Lys His Ala Pro Leu Thr Leu Ser Cys Gln Ile Arg Pro 
        35                  40                  45              


Lys Gln Leu Ser Gln Ile Ala Glu Leu Arg Val Thr Ser Leu Asp Ala 
    50                  55                  60                  


Ser Gln Ala Ser Glu Lys Asp Ile Ser Leu Val Gln Thr Pro His Lys 
65                  70                  75                  80  


Val Glu Val Asn Glu Lys Ile Glu Glu Ser Ile Glu Tyr Val Gln Asn 
                85                  90                  95      


Leu Leu Met Thr Ser Gly Asp Gly Arg Ile Ser Val Ser Pro Tyr Asp 
            100                 105                 110         


Thr Ala Val Ile Ala Leu Ile Lys Asp Leu Lys Gly Arg Asp Ala Pro 
        115                 120                 125             


Gln Phe Pro Ser Cys Leu Glu Trp Ile Ala His His Gln Leu Ala Asp 
    130                 135                 140                 


Gly Ser Trp Gly Asp Glu Phe Phe Cys Ile Tyr Asp Arg Ile Leu Asn 
145                 150                 155                 160 


Thr Leu Ala Cys Val Val Ala Leu Lys Ser Trp Asn Leu His Ser Asp 
                165                 170                 175     


Ile Ile Glu Lys Gly Val Thr Tyr Ile Lys Glu Asn Val His Lys Leu 
            180                 185                 190         


Lys Gly Ala Asn Val Glu His Arg Thr Ala Gly Phe Glu Leu Val Val 
        195                 200                 205             


Pro Thr Phe Met Gln Met Ala Thr Asp Leu Gly Ile Gln Asp Leu Pro 
    210                 215                 220                 


Tyr Asp His Pro Leu Ile Lys Glu Ile Ala Asp Thr Lys Gln Gln Arg 
225                 230                 235                 240 


Leu Lys Glu Ile Pro Lys Asp Leu Val Tyr Gln Met Pro Thr Asn Leu 
                245                 250                 255     


Leu Tyr Ser Leu Glu Gly Leu Gly Asp Leu Glu Trp Glu Arg Leu Leu 
            260                 265                 270         


Lys Leu Gln Ser Gly Asn Gly Ser Phe Leu Thr Ser Pro Ser Ser Thr 
        275                 280                 285             


Ala Ala Val Leu Met His Thr Lys Asp Glu Lys Cys Leu Lys Tyr Ile 
    290                 295                 300                 


Glu Asn Ala Leu Lys Asn Cys Asp Gly Gly Ala Pro His Thr Tyr Pro 
305                 310                 315                 320 


Val Asp Ile Phe Ser Arg Leu Trp Ala Ile Asp Arg Leu Gln Arg Leu 
                325                 330                 335     


Gly Ile Ser Arg Phe Phe Gln His Glu Ile Lys Tyr Phe Leu Asp His 
            340                 345                 350         


Ile Glu Ser Val Trp Glu Glu Thr Gly Val Phe Ser Gly Arg Tyr Thr 
        355                 360                 365             


Lys Phe Ser Asp Ile Asp Asp Thr Ser Met Gly Val Arg Leu Leu Lys 
    370                 375                 380                 


Met His Gly Tyr Asp Val Asp Pro Asn Val Leu Lys His Phe Lys Gln 
385                 390                 395                 400 


Gln Asp Gly Lys Phe Ser Cys Tyr Ile Gly Gln Ser Val Glu Ser Ala 
                405                 410                 415     


Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe Pro Gly 
            420                 425                 430         


Glu Glu Val Leu Glu Glu Ala Thr Lys Phe Ala Phe Asn Phe Leu Gln 
        435                 440                 445             


Glu Met Leu Val Lys Asp Arg Leu Gln Glu Arg Trp Val Ile Ser Asp 
    450                 455                 460                 


His Leu Phe Asp Glu Ile Lys Leu Gly Leu Lys Met Pro Trp Tyr Ala 
465                 470                 475                 480 


Thr Leu Pro Arg Val Glu Ala Ala Tyr Tyr Leu Asp His Tyr Ala Gly 
                485                 490                 495     


Ser Gly Asp Val Trp Ile Gly Lys Ser Phe Tyr Arg Met Pro Glu Ile 
            500                 505                 510         


Ser Asn Asp Thr Tyr Lys Glu Leu Ala Ile Leu Asp Phe Asn Arg Cys 
        515                 520                 525             


Gln Thr Gln His Gln Leu Glu Trp Ile His Met Gln Glu Trp Tyr Asp 
    530                 535                 540                 


Arg Cys Ser Leu Ser Glu Phe Gly Ile Ser Lys Arg Glu Leu Leu Arg 
545                 550                 555                 560 


Ser Tyr Phe Leu Ala Ala Ala Thr Ile Phe Glu Pro Glu Arg Thr Gln 
                565                 570                 575     


Glu Arg Leu Leu Trp Ala Lys Thr Arg Ile Leu Ser Lys Met Ile Thr 
            580                 585                 590         


Ser Phe Val Asn Ile Ser Gly Thr Thr Leu Ser Leu Asp Tyr Asn Phe 
        595                 600                 605             


Asn Gly Leu Asp Glu Ile Ile Ser Ser Ala Asn Glu Asp Gln Gly Leu 
    610                 615                 620                 


Ala Gly Thr Leu Leu Ala Thr Phe His Gln Leu Leu Asp Gly Phe Asp 
625                 630                 635                 640 


Ile Tyr Thr Leu His Gln Leu Lys His Val Trp Ser Gln Trp Phe Met 
                645                 650                 655     


Lys Val Gln Gln Gly Glu Gly Ser Gly Gly Glu Asp Ala Val Leu Leu 
            660                 665                 670         


Ala Asn Thr Leu Asn Ile Cys Ala Gly Leu Asn Glu Asp Val Leu Ser 
        675                 680                 685             


Asn Asn Glu Tyr Thr Ala Leu Ser Thr Leu Thr Asn Lys Ile Cys Asn 
    690                 695                 700                 


Arg Leu Ala Gln Ile Gln Asp Asn Lys Ile Leu Gln Val Val Asp Gly 
705                 710                 715                 720 


Ser Ile Lys Asp Lys Glu Leu Glu Gln Asp Met Gln Ala Leu Val Lys 
                725                 730                 735     


Leu Val Leu Gln Glu Asn Gly Gly Ala Val Asp Arg Asn Ile Arg His 
            740                 745                 750         


Thr Phe Leu Ser Val Ser Lys Thr Phe Tyr Tyr Asp Ala Tyr His Asp 
        755                 760                 765             


Asp Glu Thr Thr Asp Leu His Ile Phe Lys Val Leu Phe Arg Pro Val 
    770                 775                 780                 


Val 
785 


<210>  3
<211>  587
<212>  PRT
<213>  Unknown

<220>
<223>  CfTPS4 from Coleus forskohlii


<220>
<221>  CfTPS4
<222>  (1)..(587)

<400>  3

Met Ser Ile Thr Ile Asn Leu Arg Val Ile Ala Phe Pro Gly His Gly 
1               5                   10                  15      


Val Gln Ser Arg Gln Gly Ile Phe Ala Val Met Glu Phe Pro Arg Asn 
            20                  25                  30          


Lys Asn Thr Phe Lys Ser Ser Phe Ala Val Lys Cys Ser Leu Ser Thr 
        35                  40                  45              


Pro Thr Asp Leu Met Gly Lys Ile Lys Glu Lys Leu Arg Glu Lys Val 
    50                  55                  60                  


Asp Asn Ser Gly Ala Ala Met Ala Thr Asp Ser Ala Asp Met Pro Thr 
65                  70                  75                  80  


Asn Leu Cys Ile Val Asp Ser Leu Gln Arg Leu Gly Val Glu Lys Tyr 
                85                  90                  95      


Phe Gln Ser Glu Ile Asp Thr Val Leu Asp Asp Ala Tyr Arg Leu Trp 
            100                 105                 110         


Gln Leu Lys Gln Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met 
        115                 120                 125             


Ala Phe Arg Leu Leu Arg Val Lys Gly Tyr Asp Val Ser Ser Glu Glu 
    130                 135                 140                 


Leu Ala Pro Tyr Ala Asp Gln Glu Gly Met Asn Leu Gln Thr Ile Asp 
145                 150                 155                 160 


Leu Ala Ala Val Ile Glu Leu Tyr Arg Ala Ala Gln Glu Arg Val Ala 
                165                 170                 175     


Glu Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Thr Phe 
            180                 185                 190         


Leu Lys Gln Gln Leu Leu Ala Gly Ala Ile Pro Asp Gln Lys Leu His 
        195                 200                 205             


Lys Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg 
    210                 215                 220                 


Met Gly Val Arg Lys Gly Leu Asp Leu Tyr Asp Ala Gly Tyr Tyr Lys 
225                 230                 235                 240 


Ala Leu Lys Ala Ala Asp Arg Leu Val Asp Leu Cys Asn Glu Asp Leu 
                245                 250                 255     


Leu Ala Phe Ala Arg Gln Asp Phe Asn Ile Asn Gln Ala Gln His Arg 
            260                 265                 270         


Lys Glu Leu Glu Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp 
        275                 280                 285             


Lys Leu Glu Phe Gly Arg Asp Val Val Arg Val Ser Asn Phe Leu Thr 
    290                 295                 300                 


Ser Ala Ile Leu Gly Asp Pro Glu Leu Ser Glu Val Arg Leu Val Phe 
305                 310                 315                 320 


Ala Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His 
                325                 330                 335     


Gly Gly Pro Arg Glu Glu Ser His Lys Ile Leu Glu Leu Ile Lys Glu 
            340                 345                 350         


Trp Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Lys Glu Val Glu Ile 
        355                 360                 365             


Leu Tyr Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Arg Ala 
    370                 375                 380                 


Asn Val Glu Gln Gly Arg Asn Val Glu Pro Phe Leu Arg Thr Leu Trp 
385                 390                 395                 400 


Val Gln Ile Leu Ser Ile Phe Lys Ile Glu Leu Asp Thr Trp Ser Asp 
                405                 410                 415     


Asp Thr Ala Leu Thr Leu Asp Asp Tyr Leu Asn Asn Ser Trp Val Ser 
            420                 425                 430         


Ile Gly Cys Arg Ile Cys Ile Leu Met Ser Met Gln Phe Ile Gly Met 
        435                 440                 445             


Lys Leu Pro Glu Glu Met Leu Leu Ser Glu Glu Cys Val Asp Leu Cys 
    450                 455                 460                 


Arg His Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe 
465                 470                 475                 480 


Glu Lys Glu Arg Lys Glu Asn Thr Gly Asn Ala Val Ser Leu Leu Leu 
                485                 490                 495     


Ala Ala His Lys Gly Glu Arg Ala Phe Ser Glu Glu Glu Ala Ile Ala 
            500                 505                 510         


Lys Ala Lys Tyr Leu Ala Asp Cys Asn Arg Arg Ser Leu Met Gln Ile 
        515                 520                 525             


Val Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Met Phe 
    530                 535                 540                 


Leu Lys Val Cys Arg Ile Gly Cys Tyr Leu Tyr Ala Ser Gly Asp Glu 
545                 550                 555                 560 


Phe Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr 
                565                 570                 575     


Glu Pro Leu Gln Ile His Pro Pro Pro Ala Asn 
            580                 585         


<210>  4
<211>  598
<212>  PRT
<213>  Unknown

<220>
<223>  TPS3 from Coleus forskohlii


<220>
<221>  CfTPS3
<222>  (1)..(598)

<400>  4

Met Ser Ser Leu Ala Gly Asn Leu Arg Val Ile Pro Phe Ser Gly Asn 
1               5                   10                  15      


Arg Val Gln Thr Arg Thr Gly Ile Leu Pro Val His Gln Thr Pro Met 
            20                  25                  30          


Ile Thr Ser Lys Ser Ser Ala Ala Val Lys Cys Ser Leu Thr Thr Pro 
        35                  40                  45              


Thr Asp Leu Met Gly Lys Ile Lys Glu Val Phe Asn Arg Glu Val Asp 
    50                  55                  60                  


Thr Ser Pro Ala Ala Met Thr Thr His Ser Thr Asp Ile Pro Ser Asn 
65                  70                  75                  80  


Leu Cys Ile Ile Asp Thr Leu Gln Arg Leu Gly Ile Asp Gln Tyr Phe 
                85                  90                  95      


Gln Ser Glu Ile Asp Ala Val Leu His Asp Thr Tyr Arg Leu Trp Gln 
            100                 105                 110         


Leu Lys Lys Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met Ala 
        115                 120                 125             


Phe Arg Leu Leu Arg Val Lys Gly Tyr Glu Val Ala Ser Asp Glu Leu 
    130                 135                 140                 


Ala Pro Tyr Ala Asp Gln Glu Arg Ile Asn Leu Gln Thr Ile Asp Val 
145                 150                 155                 160 


Pro Thr Val Val Glu Leu Tyr Arg Ala Ala Gln Glu Arg Leu Thr Glu 
                165                 170                 175     


Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Ala Phe Leu 
            180                 185                 190         


Lys Gln Gln Leu Leu Thr Asp Ala Ile Pro Asp Lys Lys Leu His Lys 
        195                 200                 205             


Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg Met 
    210                 215                 220                 


Gly Val Arg Arg Asn Leu Asp Leu Tyr Asp Ile Ser His Tyr Lys Ser 
225                 230                 235                 240 


Leu Lys Ala Ala His Arg Phe Tyr Asn Leu Ser Asn Glu Asp Ile Leu 
                245                 250                 255     


Ala Phe Ala Arg Gln Asp Phe Asn Ile Ser Gln Ala Gln His Gln Lys 
            260                 265                 270         


Glu Leu Gln Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp Thr 
        275                 280                 285             


Leu Lys Phe Gly Arg Asp Val Val Arg Ile Gly Asn Phe Leu Thr Ser 
    290                 295                 300                 


Ala Met Ile Gly Asp Pro Glu Leu Ser Asp Leu Arg Leu Ala Phe Ala 
305                 310                 315                 320 


Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His Gly 
                325                 330                 335     


Gly Pro Lys Glu Glu Ser Tyr Glu Ile Leu Glu Leu Val Lys Glu Trp 
            340                 345                 350         


Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Glu Glu Val Glu Ile Leu 
        355                 360                 365             


Phe Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Met Ala His 
    370                 375                 380                 


Ile Glu Gln Gly Arg Ser Val Lys Asp Leu Leu Val Lys Leu Trp Val 
385                 390                 395                 400 


Glu Ile Leu Ser Val Phe Arg Ile Glu Leu Asp Thr Trp Thr Asn Asp 
                405                 410                 415     


Thr Ala Leu Thr Leu Glu Glu Tyr Leu Ser Gln Ser Trp Val Ser Ile 
            420                 425                 430         


Gly Cys Arg Ile Cys Ile Leu Ile Ser Met Gln Phe Gln Gly Val Lys 
        435                 440                 445             


Leu Ser Asp Glu Met Leu Gln Ser Glu Glu Cys Thr Asp Leu Cys Arg 
    450                 455                 460                 


Tyr Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe Glu 
465                 470                 475                 480 


Lys Glu Arg Lys Glu Asn Thr Gly Asn Ser Val Ser Leu Leu Gln Ala 
                485                 490                 495     


Ala His Lys Asp Glu Arg Val Ile Asn Glu Glu Glu Ala Cys Ile Lys 
            500                 505                 510         


Val Lys Glu Leu Ala Glu Tyr Asn Arg Arg Lys Leu Met Gln Ile Val 
        515                 520                 525             


Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Leu Phe Leu 
    530                 535                 540                 


Lys Ala Cys Arg Ile Gly Cys Tyr Leu Tyr Ser Ser Gly Asp Glu Phe 
545                 550                 555                 560 


Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr Glu 
                565                 570                 575     


Pro Leu Pro Ile Ser Pro Pro Glu Ala Asn Asn Ala Ser Gly Glu Lys 
            580                 585                 590         


Met Ser Cys Val Ser Asn 
        595             


<210>  5
<211>  792
<212>  PRT
<213>  Euphorbia peplus


<220>
<221>  EpTPS8
<222>  (1)..(792)

<400>  5

Met Gln Val Ser Leu Ser Leu Thr Thr Gly Ser Glu Pro Cys Ile Thr 
1               5                   10                  15      


Arg Ile His Ala Pro Ser Asp Ala Pro Leu Lys Gln Arg Asn Asn Glu 
            20                  25                  30          


Arg Glu Lys Gly Thr Leu Glu Leu Asn Gly Lys Val Ser Leu Lys Lys 
        35                  40                  45              


Met Gly Glu Met Leu Arg Thr Ile Glu Asn Val Pro Ile Val Gly Ser 
    50                  55                  60                  


Thr Ser Ser Tyr Asp Thr Ala Trp Val Gly Met Val Pro Cys Ser Ser 
65                  70                  75                  80  


Asn Ser Ser Lys Pro Leu Phe Pro Glu Ser Leu Lys Trp Ile Met Glu 
                85                  90                  95      


Asn Gln Asn Pro Glu Gly Asn Trp Ala Val Asp His Ala His His Pro 
            100                 105                 110         


Leu Leu Leu Lys Asp Ser Leu Ser Ser Thr Leu Ala Cys Val Leu Ala 
        115                 120                 125             


Leu His Lys Trp Asn Leu Ala Pro Gln Leu Val His Ser Gly Leu Asp 
    130                 135                 140                 


Phe Ile Gly Ser Asn Leu Trp Ala Ala Met Asp Phe Arg Gln Arg Ser 
145                 150                 155                 160 


Pro Leu Gly Phe Asp Val Ile Phe Pro Gly Met Ile His Gln Ala Ile 
                165                 170                 175     


Asp Leu Gly Ile Asn Leu Pro Phe Asn Asn Ser Ser Ile Glu Asn Met 
            180                 185                 190         


Leu Thr Asn Pro Leu Leu Asp Ile Gln Ser Phe Glu Ala Gly Lys Thr 
        195                 200                 205             


Ser His Ile Ala Tyr Phe Ala Glu Gly Leu Gly Ser Arg Leu Lys Asp 
    210                 215                 220                 


Trp Glu Gln Leu Leu Gln Tyr Gln Thr Ser Asn Gly Ser Leu Phe Asn 
225                 230                 235                 240 


Ser Pro Ser Thr Thr Ala Ala Ala Ala Ile His Leu Arg Asp Glu Lys 
                245                 250                 255     


Cys Leu Asn Tyr Leu His Ser Leu Thr Lys Gln Phe Asp Asn Gly Ala 
            260                 265                 270         


Val Pro Thr Leu Tyr Pro Leu Asp Ala Arg Thr Arg Ile Ser Ile Ile 
        275                 280                 285             


Asp Ser Leu Glu Lys Phe Gly Ile His Ser His Phe Ile Gln Glu Met 
    290                 295                 300                 


Thr Ile Leu Leu Asp Gln Ile Tyr Ser Phe Trp Lys Glu Gly Asn Glu 
305                 310                 315                 320 


Glu Ile Phe Lys Asp Pro Gly Cys Cys Ala Thr Ala Phe Arg Leu Leu 
                325                 330                 335     


Arg Lys His Gly Tyr Asp Val Ser Ser Asp Ser Leu Ala Glu Phe Glu 
            340                 345                 350         


Lys Lys Glu Ile Phe Tyr His Ser Ser Ala Ala Ser Ala His Glu Ile 
        355                 360                 365             


Asp Thr Lys Ser Ile Leu Glu Leu Phe Arg Ala Ser Gln Met Lys Ile 
    370                 375                 380                 


Leu Gln Asn Glu Pro Ile Leu Asp Arg Ile Tyr Asp Trp Thr Ser Ile 
385                 390                 395                 400 


Phe Leu Arg Asp Gln Leu Val Lys Gly Leu Ile Glu Asn Lys Ser Leu 
                405                 410                 415     


Tyr Glu Glu Val Asn Phe Ala Leu Gly His Pro Phe Ala Asn Leu Asp 
            420                 425                 430         


Arg Leu Glu Ala Arg Ser Tyr Ile Asp Asn Tyr Asp Pro Tyr Asp Val 
        435                 440                 445             


Pro Leu Leu Lys Thr Ser Tyr Arg Ser Ser Asn Ile Asp Asn Lys Asp 
    450                 455                 460                 


Leu Trp Thr Ile Ala Phe Gln Asp Phe Asn Lys Cys Gln Ala Leu His 
465                 470                 475                 480 


Arg Val Glu Leu Asp Tyr Leu Glu Lys Trp Val Lys Glu Tyr Lys Leu 
                485                 490                 495     


Asp Thr Leu Lys Trp Ala Arg Gln Lys Thr Glu Tyr Ala Leu Phe Thr 
            500                 505                 510         


Ile Gly Ala Ile Leu Ser Glu Pro Glu Tyr Ala Asp Ala Arg Ile Ser 
        515                 520                 525             


Trp Ser Gln Asn Thr Val Phe Val Thr Ile Val Asp Asp Phe Phe Asp 
    530                 535                 540                 


Tyr Gly Gly Ser Leu Asp Glu Cys Arg Asn Leu Ile Asn Leu Met His 
545                 550                 555                 560 


Lys Trp Asp Asp His Leu Thr Val Gly Phe Leu Ser Glu Lys Val Glu 
                565                 570                 575     


Ile Val Phe Tyr Ser Met Tyr Gly Thr Leu Asn Asp Leu Ala Ala Lys 
            580                 585                 590         


Ala Glu Val Arg Gln Gly Arg Cys Val Arg Ser His Leu Val Asn Leu 
        595                 600                 605             


Trp Ile Trp Val Met Glu Asn Met Leu Lys Glu Arg Glu Trp Ala Asp 
    610                 615                 620                 


Tyr Asn Leu Val Pro Thr Phe Tyr Glu Tyr Val Ala Ala Gly His Ile 
625                 630                 635                 640 


Thr Ile Gly Leu Gly Pro Val Leu Leu Ile Ala Leu Tyr Phe Met Gly 
                645                 650                 655     


Tyr Pro Leu Ser Glu Asp Val Val Gln Ser Gln Glu Tyr Lys Gly Val 
            660                 665                 670         


Tyr Leu Asn Val Ser Ile Ile Ala Arg Leu Leu Asn Asp Arg Val Thr 
        675                 680                 685             


Val Lys Arg Glu Ser Ala Gln Gly Lys Leu Asn Gly Val Ser Leu Phe 
    690                 695                 700                 


Val Glu His Gly Arg Gly Ala Val Asp Glu Glu Thr Ser Met Lys Glu 
705                 710                 715                 720 


Val Glu Arg Leu Val Glu Ser His Lys Arg Glu Leu Leu Arg Leu Ile 
                725                 730                 735     


Val Gln Lys Thr Glu Gly Ser Val Val Pro Gln Ser Cys Lys Asp Leu 
            740                 745                 750         


Ala Trp Arg Val Ser Lys Val Leu His Leu Leu Tyr Met Asp Asp Asp 
        755                 760                 765             


Gly Phe Thr Cys Pro Val Lys Met Leu Asn Ala Thr Asn Ala Ile Val 
    770                 775                 780                 


Asn Glu Pro Leu Leu Leu Thr Ser 
785                 790         


<210>  6
<211>  2322
<212>  DNA
<213>  Unknown

<220>
<223>  CfTPS2 from Coleus forskohlii


<220>
<221>  CfTPS2
<222>  (1)..(2322)

<400>  6
atgaaaatgt tgatgatcaa aagtcaattt cgtgtacatt caatagtcag tgcatgggcg       60

aacaacagca ataaaaggca gtcattgggt caccaaattc gtcgaaagca aagatcacaa      120

gtaaccgagt gtcgagttgc aagtctggat gcgttgaatg gaattcaaaa agtcggccca      180

gccaccattg ggactcctga agaggaaaat aaaaagattg aggattccat tgagtacgtg      240

aaggagttgt tgaagacaat gggcgacggg cgaatcagcg tttccccgta cgacacagca      300

atagttgccc tgattaagga cttggaagga ggtgatggac cagagtttcc atcttgtcta      360

gagtggattg cacagaatca actggctgat ggttcttggg gggatcactt cttctgtatt      420

tatgatcggg ttgttaatac agcagcttgt gtggtcgcct taaagtcgtg gaacgttcac      480

gcagacaaga ttgagaaagg agcagtgtac ctgaaggaga atgtgcataa acttaaagat      540

gggaagattg agcacatgcc cgcagggttt gaatttgtgg ttcctgccac tcttgaaaga      600

gccaaagcct tggggatcaa aggtcttccc tatgatgatc ctttcatcag ggaaatttat      660

agtgcaaaac aaacaagatt gaccaagata ccaaagggca tgatctacga atctccaact      720

tctttattat atagtttaga cggtctggaa ggcttggagt gggacaagat actgaaactg      780

cagtcggccg atggctcatt catcacctct gtgtcgtcta ctgccttcgt attcatgcac      840

accaacgacc ttaaatgcca cgccttcatc aaaaatgccc tcaccaattg caacggggga      900

gtaccccaca cgtatccagt ggatatcttc gcacgacttt gggcagtgga ccgactgcaa      960

cgcctcggaa tatctcgatt ctttgagcct gagatcaaat atttaatgga tcacatcaat     1020

aacgtgtgga gggagaaggg agttttcagt tcaaggcatt cacaatttgc ggatattgac     1080

gacacatcca tgggcatcag gcttctgaaa atgcacggat acaatgtcaa cccaaatgca     1140

cttgaacatt tcaaacagaa agatgggaag tttacatgct atgctgatca acatatcgag     1200

tctccatccc ccatgtacaa tctctacagg gctgctcagc ttcgttttcc aggagaagaa     1260

attcttcaac aagcccttca atttgcctat aattttctac atgaaaacct agccagcaat     1320

cactttcaag aaaaatgggt catatccgac cacctaattg atgaggtaag gatcgggctg     1380

aagatgccat ggtacgccac cctaccgcga gtggaggctt catactatct tcaacattat     1440

ggtggatcca gcgacgtatg gattggcaaa actttataca gaatgccaga aatcagtaac     1500

gacacataca aaatacttgc acaattggac ttcaacaaat gtcaagcaca acatcagttg     1560

gaatggatgt ccatgaaaga gtggtatcaa agtaataatg ttaaagaatt tgggataagc     1620

aagaaagaac ttcttcttgc ttactttttg gctgctgcaa ccatgtttga acccgaacgc     1680

acacaagaga ggattatgtg ggcgaaaact caagtcgttt ctcggatgat cacatcattt     1740

ctcaacaaag aaaacacaat gtcattcgac ctaaagattg cacttttaac ccaaccccaa     1800

catcaaataa atggttctga gatgaagaat ggacttgctc aaactcttcc tgcagccttc     1860

cgacaactac tcaaggaatt cgacaaatac acaagacatc aattgaggaa tacttggaac     1920

aaatggttga tgaaactgaa gcaaggagat gacaatggcg gcgcagatgc agagctcctt     1980

gcaaacacat taaacatatg tgctggacat aacgaagaca tattatcgca ctatgaatac     2040

accgctctct cctccctcac aaacaaaata tgtcagcgtc taagtcaaat tcaagataaa     2100

aagatgctgg aaattgagga ggggagcata aaagataagg agatggagct cgaaatacaa     2160

acattggtga agttagtcct ccaagaaacc agtgggggta tcgatagaaa catcaagcaa     2220

acatttttat cagtattcaa gacattttac tacagggcct accacgatgc taagactatc     2280

gatgcccata ttttccaagt actatttgaa ccagtggtct ga                        2322


<210>  7
<211>  2358
<212>  DNA
<213>  Salvia sclarea


<220>
<221>  SsLPPS
<222>  (1)..(2358)

<400>  7
atgacttctg taaatttgag cagagcacca gcagcgatta cccggcgcag gctgcagcta       60

cagccggaat ttcatgccga gtgttcatgg ctgaaaagca gcagcaaaca cgcgcccttg      120

accttgagtt gccaaatccg tcctaagcaa ctctcccaaa tagctgaatt gagagtaaca      180

agcctggatg cgtcgcaagc gagtgaaaaa gacatttccc ttgttcaaac tccgcataag      240

gttgaggtta atgaaaagat cgaggagtca atcgagtacg tccaaaatct gttgatgacg      300

tcgggcgacg ggcgaataag cgtgtcaccc tatgacacgg cagtgatcgc cctgatcaag      360

gacttgaaag ggcgcgacgc cccgcagttt ccgtcatgtc tcgagtggat cgcgcaccac      420

caactggctg atggctcatg gggcgacgaa ttcttctgta tttatgatcg gattctaaat      480

acattggcat gtgtcgtagc cttgaaatca tggaaccttc actctgatat tattgaaaaa      540

ggagtgacgt acatcaagga gaatgtgcat aaacttaaag gtgcaaatgt tgagcacagg      600

acagcggggt tcgaacttgt ggttcctact tttatgcaaa tggccacaga tttgggcatc      660

caagatctgc cctatgatca tcccctcatc aaggagattg ctgacacaaa acaacaaaga      720

ttgaaagaga tacccaagga tttggtttac caaatgccaa cgaatttact gtacagttta      780

gaagggttag gagatttgga gtgggaaagg ctactgaaac tgcagtcggg caatggctcc      840

ttcctcactt cgccgtcgtc caccgccgcc gtcttgatgc ataccaaaga tgaaaaatgt      900

ttgaaataca tcgaaaacgc cctcaagaat tgcgacggag gagcaccaca tacttatcca      960

gtcgatatct tctcaagact ttgggcaatc gataggctac aacgcctagg aatttctcgt     1020

ttcttccagc acgagatcaa gtatttctta gatcacatcg aaagcgtttg ggaggagacc     1080

ggagttttca gtggaagata tacgaaattt agcgatattg atgacacgtc catgggcgtt     1140

aggcttctca aaatgcacgg atacgacgtc gatccaaatg tactaaaaca tttcaagcaa     1200

caagatggta aattttcctg ctacattggt caatcggtcg agtctgcatc tccaatgtac     1260

aatctttata gggctgctca actaagattt ccaggagaag aagttcttga agaagccact     1320

aaatttgcct ttaacttctt gcaagaaatg ctagtcaaag atcgacttca agaaagatgg     1380

gtgatatccg accacttatt tgatgagata aagctggggt tgaagatgcc atggtacgcc     1440

actctacccc gagtcgaggc tgcatattat ctagaccatt atgctggttc tggtgatgta     1500

tggattggca agagtttcta caggatgcca gaaatcagca atgatacata caaggagctt     1560

gcgatattgg atttcaacag atgccaaaca caacatcagt tggagtggat ccacatgcag     1620

gaatggtacg acagatgcag ccttagcgaa ttcgggataa gcaaaagaga gttgcttcgc     1680

tcttactttc tggccgcagc aaccatattc gaaccggaga gaactcaaga gaggcttctg     1740

tgggccaaaa ccagaattct ttctaagatg atcacttcat ttgtcaacat tagtggaaca     1800

acactatctt tggactacaa tttcaatggc ctcgatgaaa taattagtag tgccaatgaa     1860

gatcaaggac tggctgggac tctgctggca accttccatc aacttctaga cggattcgat     1920

atatacactc tccatcaact caaacatgtt tggagccaat ggttcatgaa agtgcagcaa     1980

ggagagggaa gcggcgggga agacgcggtg ctcctagcga acacgctcaa catctgcgcc     2040

ggcctcaacg aagacgtgtt gtccaacaat gaatacacgg ctctgtccac cctcacaaat     2100

aaaatctgca atcgcctcgc ccaaattcaa gacaataaga ttctccaagt tgtggatggg     2160

agcataaagg ataaggagct agaacaggat atgcaggcgt tggtgaagtt agtgcttcaa     2220

gaaaatggcg gcgccgtaga cagaaacatc agacacacgt ttttgtcggt ttccaagact     2280

ttctactacg atgcctacca cgacgatgag acgaccgatc ttcatatctt caaagtactc     2340

tttcgaccgg ttgtatga                                                   2358


<210>  8
<211>  1764
<212>  DNA
<213>  Unknown

<220>
<223>  CfTPS4 from Coleus forskohlii


<220>
<221>  CfTPS4
<222>  (1)..(1764)

<400>  8
atgtcaatca ccatcaacct tcgagttatc gctttccccg gccatggagt tcagagcagg       60

caaggaatat ttgcagtcat ggaatttcca aggaacaaga acacctttaa atcatccttt      120

gctgttaaat gcagcctctc tactccaaca gatttgatgg gaaagataaa agaaaagttg      180

agcgagaagg ttgataattc tgtggcagcc atggctactg attctgccga tatgcccact      240

aatctctgca tcgtcgactc cctccagagg ctgggagtcg aaaaatattt ccaatccgaa      300

atcgacactg ttctcgatga tgcataccgg ttatggcagc tgaagcagaa agatatattt      360

tcagacatta ctactcatgc aatggcgttt agacttctgc gagtcaaagg atacgatgtt      420

tcatcagagg agctggctcc atacgctgat caagagggca tgaacttgca aacgattgat      480

ctggcggcgg tcatcgagct gtacagagca gcacaggaga gagtggctga ggaagacagc      540

actcttgaga aactgtatgt ctggaccagc acctttctga agcagcagtt gctggctggc      600

gccattcctg accagaaatt gcacaaacag gtggagtact acttgaagaa ctaccacggc      660

atattagata gaatgggagt tagaaaagga ctcgacctgt atgatgctgg ctattacaag      720

gccctcaaag ctgcagatag gttggttgat ctatgcaatg aagaccttct agcatttgca      780

aggcaagatt ttaatattaa ccaagcccaa caccgcaaag aacttgagca actgcaaagg      840

tggtatgcag attgtaggtt ggacaaactc gagtttggaa gagatgtggt gcgtgtatcg      900

aattttctga cttcagccat ccttggtgat ccagagcttt ctgaagtccg tctagtgttt      960

gccaaacata ttgtgctagt gactaggata gatgattttt tcgatcatgg cgggcctaga     1020

gaagaatcac acaagatcct tgaactaata aaagaatgga aagagaagcc agctggagaa     1080

tatgtttcca aagaagttga gatcctatat accgcggtgt acaatacggt aaacgagttg     1140

gcagagaggg caaatgttga acaagggcga aatgttgaac catttctacg tacactgtgg     1200

gttcaaatac tgtcgatttt caagatagag ttggatacat ggagcgatga cacagcacta     1260

accttggatg attacttgaa caactcatgg gtgtcgattg gttgtagaat ctgcattctc     1320

atgtccatgc aattcattgg tatgaagtta ccagaagaaa tgcttctcag tgaagagtgc     1380

gttgatttgt gtaggcatgt ttccatggtc gaccgtctgc tcaatgatgt ccaaactttt     1440

gagaaggaac ggaaagaaaa tacaggaaac gctgtgagcc ttctgctagc agctcacaag     1500

ggtgaaagag ccttcagtga agaggaagcc atagcaaaag cgaaatattt ggctgactgt     1560

aacaggagaa gtctgatgca gattgtgtat aaaacaggaa ccattttccc aagaaaatgc     1620

aaagatatgt tcttgaaggt gtgcaggatt ggttgctatt tgtatgcgag tggcgacgaa     1680

tttacttccc ctcaacaaat gatggaagat atgaagtcat tagtttatga gcccctccaa     1740

attcaccctc cacctgctaa ctaa                                            1764


<210>  9
<211>  1704
<212>  DNA
<213>  Unknown

<220>
<223>  CfTPS3 from Coleus forskohlii


<220>
<221>  CfTPS3
<222>  (1)..(1704)

<400>  9
atgatcacct ctaaatcatc tgcagctgtt aaatgcagcc tcaccacgcc aacagatttg       60

atggggaaaa taaaagaggt cttcaacagg gaagtcgata cttctccggc agccatgact      120

actcattcta cagatatacc ctctaatctc tgcataatcg acaccctcca gaggctggga      180

atcgaccaat acttccaatc cgaaatcgac gctgttctac atgatacata caggttatgg      240

caactgaaaa agaaagatat attttcggat attactactc atgcaatggc gttcagactt      300

ttgcgagtca aaggatatga agttgcatca gacgaactgg ctccatacgc tgatcaagag      360

cgcattaacc tgcaaaccat tgatgtgccg acagttgttg agctatacag agcagcacag      420

gagagattaa ctgaagaaga tagcactctt gagaaactgt atgtttggac cagcgccttt      480

ctgaagcagc agttgctcac tgatgccatt cctgacaaga aattgcacaa acaagtggaa      540

tactacttga agaactacca tggcatatta gatagaatgg gagtgagacg aaacctcgac      600

ctatatgaca taagccatta taaaagtctc aaagctgctc acaggttcta taatctgagt      660

aatgaagata tcctagcatt tgcgaggcaa gattttaata ttagccaagc ccaacaccag      720

aaagaacttc agcagctgca aaggtggtat gcagattgta ggttggacac gttgaaattt      780

ggaagagatg tagtgcgtat aggaaatttt ctgacttcag caatgattgg tgatcctgaa      840

ttgtctgacc tccgtctagc gtttgccaaa catatagtgc tcgtaacacg tattgatgat      900

tttttcgatc acggtgggcc taaagaagaa tcatacgaga tccttgaatt agtaaaagaa      960

tggaaagaga agccagcagg agaatatgtt tctgaagaag ttgaaatcct atttacagca     1020

gtatacaata cagtaaacga gttggcagaa atggctcata tcgaacaagg acgaagcgtt     1080

aaagaccttc tagttaaact gtgggttgaa atactatcag ttttcagaat agaattggat     1140

acatggacca acgacacagc acttacctta gaagagtact tgtcacaatc ctgggtgtcc     1200

attggctgca gaatctgcat tctcatatca atgcaattcc aaggtgtaaa attatctgat     1260

gaaatgcttc agagtgaaga atgcactgat ttgtgtcggt atgtttcaat ggttgaccgg     1320

ctgctcaacg atgtgcaaac ttttgagaag gaacgcaagg aaaatacagg aaatagtgtg     1380

agccttctgc aagcagctca caaagatgaa agagtcatta atgaagagga agcttgtata     1440

aaggtaaaag aattggctga atataacagg agaaaactga tgcagattgt ctacaaaaca     1500

ggaaccattt tcccaagaaa atgcaaagat ctgtttttga aggcatgcag aattggttgt     1560

tatttgtact caagtggcga cgaatttact tcgcctcaac aaatgatgga agatatgaag     1620

tcactggttt atgaacccct accaatttct cctcctgaag ctaataatgc aagtggagaa     1680

aaaatgagtt gtgtcagcaa ctag                                            1704


<210>  10
<211>  2379
<212>  DNA
<213>  Euphorbia peplus


<220>
<221>  EpTPS8
<222>  (1)..(2379)

<400>  10
atgcaagtct ctctctccct caccactggc tccgagcctt gcattaccag aatccatgct       60

ccatctgatg caccattgaa acagcggaac aatgaaagag agaaggggac actagaacta      120

aatgggaaag tttcgctgaa gaaaatggga gagatgctga ggacaataga aaatgtacct      180

atagtaggta gtacgtcgtc gtatgataca gcatgggtcg gtatggtgcc ttgttcatcg      240

aattcgtcga aaccgctatt tccagaaagc ttgaaatgga taatggagaa tcaaaatcca      300

gaagggaatt gggcagttga tcatgctcat catcctcttc ttcttaaaga ctctctttct      360

tccactcttg cttgtgtcct tgctttgcac aaatggaatt tggctcccca gcttgttcac      420

tccggtttgg acttcatcgg ctctaatcta tgggcagcta tggactttcg acaacgatct      480

cctctcggat ttgatgttat atttccagga atgatccacc aagctattga tttgggcatc      540

aatcttcctt tcaacaactc ttcaattgag aacatgctca ctaacccact tttggacatt      600

caaagttttg aagcaggaaa aactagccat attgcatact ttgccgaggg attaggaagt      660

agattaaagg attgggaaca acttcttcaa tatcaaacaa gtaacggttc gctcttcaat      720

tcaccttcta caactgctgc cgctgctatt catctacgtg acgaaaaatg tcttaattac      780

ttgcattctc taaccaaaca attcgataat ggtgctgttc caacacttta tcctctcgat      840

gcgcgtacca gaatctccat aatcgatagt ttggaaaagt ttgggatcca ttcacatttc      900

atccaagaaa tgacaattct actagatcaa atatacagct tctggaaaga agggaatgaa      960

gaaatattta aagaccctgg atgttgtgca acagcattcc gactgctgcg aaagcatggt     1020

tatgatgttt cttcagattc cttggcagag tttgagaaaa aagagatatt ttaccattca     1080

tcagcagcta gtgcacacga aatcgatacc aagtctattc tagaattatt cagagcttcc     1140

caaatgaaaa ttttgcaaaa tgaaccaata ctcgacagaa tttacgattg gactagcatt     1200

tttctgagag accagctagt gaaaggtcta atcgaaaaca agagtctgta cgaagaagtt     1260

aattttgctt tgggacatcc atttgctaat ctggatagac tcgaagctcg ttcttacatc     1320

gacaattacg atccatatga tgtcccactt cttaagacat cttacaggtc atccaatatt     1380

gataacaaag atctatggac aattgcattc caagatttca acaagtgcca agccttgcac     1440

cgtgtggaac ttgattatct ggagaaatgg gtgaaagaat acaaattgga cactctgaag     1500

tgggcaaggc agaagactga gtatgcatta tttacgatag gcgcaatcct ttcggagcct     1560

gaatacgctg atgctcgcat ctcatggtca cagaatactg tttttgtgac tattgttgat     1620

gatttctttg actatggtgg ttcgttggat gaatgtcgta acctcattaa ccttatgcac     1680

aagtgggatg atcacttaac cgttggattc ttgtcggaaa aagtggaaat cgtattttat     1740

tcgatgtatg gcacactcaa tgaccttgct gccaaagccg aagtacgaca aggccgatgt     1800

gttcgaagtc acttagttaa tttatggatc tgggtgatgg aaaacatgtt aaaggagaga     1860

gaatgggcag attacaatct ggtgcctaca ttttacgagt acgtagccgc tggacatata     1920

actatcggct taggacctgt gcttcttatt gccctctatt ttatggggta tccgctttct     1980

gaggatgtgg ttcaaagtca agaatacaag ggtgtttatt tgaatgtcag catcattgct     2040

cgacttctaa atgatcgcgt aactgttaag agggaaagtg cgcaaggaaa gcttaatggt     2100

gtgtcattgt tcgtcgaaca tggtcgtggc gcggttgatg aggaaactag tatgaaggaa     2160

gtagaaagac tggtagagag ccataagaga gaattattaa gattgattgt gcagaaaacg     2220

gaaggcagtg tcgtcccgca aagttgcaaa gatctagctt ggagggttag caaagttttg     2280

caccttctat atatggatga tgatggtttt acatgtcctg tgaagatgct taatgctaca     2340

aatgcaattg tcaacgaacc actcctttta acttcataa                            2379


<210>  11
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Class II diterpene synthase domain


<220>
<221>  DOMAIN
<222>  (1)..(4)
<223>  X: any amino acid

<400>  11

Asp Xaa Asp Asp 
1               


<210>  12
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Class I diterpene synthase domain


<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  X: any amino acid

<400>  12

Asp Asp Xaa Xaa Asp 
1               5   


<210>  13
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri046 forward primer for amplification of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(28)
<223>  CfTPS1_F

<400>  13
cagaatgggg tctctatcca ctatgaac                                          28


<210>  14
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri047 reverse primer for amplification of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  CfTPS1_R

<400>  14
cagcatattc aggcgactgg tt                                                22


<210>  15
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri048 forward primer for amplification of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(30)
<223>  CfTPS2_F

<400>  15
agattgagga ttccattgag tacgtgaagg                                        30


<210>  16
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri049 reverse primer for amplification of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(30)
<223>  CfTPS2_R

<400>  16
gaagtttaat atccttcatt ctttattaca                                        30


<210>  17
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri099 forward primer for amplification of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(27)
<223>  CfTPS3_F

<400>  17
agctccattc aactagagtc atgtcgt                                           27


<210>  18
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri100 reverse primer for amplification of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(28)
<223>  CfTPS3_R

<400>  18
ttcatctggc ttaactagtt gctgacac                                          28


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri0101 forward primer for amplification of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(25)
<223>  CfTPS4_F

<400>  19
gtgcactctc caccaacgat aaact                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri102 reverse primer for amplification of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(25)
<223>  CfTPS4_R

<400>  20
gcttcacagc ctatgaatac atgat                                             25


<210>  21
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri051 forward primer for amplification of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  CfTPS14_F

<400>  21
tatgacacgg catgggttgc ta                                                22


<210>  22
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri052 reverse primer for amplification of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(29)
<223>  CfTPS14_R

<400>  22
tcactcaaaa tttattctaa gacaagagg                                         29


<210>  23
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri064 forward primer for E. coli expression of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CfTPS1_PciI_pmF

<400>  23
gctttagcaa catgtcatgg atgaac                                            26


<210>  24
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri065 reverse primer for E. coli expression of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  CfTPS1_XhoI_R

<400>  24
cagcactcga gggcgactgg tt                                                22


<210>  25
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri068 forward primer for E. coli expression of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(25)
<223>  CfTPS2_BspHI_pmF

<400>  25
cacaagtaat catgagtcga gttgc                                             25


<210>  26
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri069 reverse primer for E. coli expression of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(23)
<223>  CfTPS2_XhoI_R

<400>  26
ccaatgttct cgagcactgg ttc                                               23


<210>  27
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri146 forward primer for E. coli expression of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(37)
<223>  CfTPS3_NcoI_inFusion_F

<400>  27
aggagatata ccatggctcc gatgatcacc tctaaat                                37


<210>  28
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri147 reverse primer for E. coli expression  of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(35)
<223>  CfTPS3_XhoI_inFusion_R

<400>  28
ggtggtggtg ctcgaggttg ctgacacaac tcatt                                  35


<210>  29
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri117 forward primer for E. coli expression of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CfTPS4_BspHI_pmF

<400>  29
catcctttgt catgaaatgc agcctc                                            26


<210>  30
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri118 reverse primer for E. coli expression of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(29)
<223>  CfTPS4_NotI_R

<400>  30
ttgttaggcg gccgctggag ggtgaattt                                         29


<210>  31
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri066 forward primer for E. coli expression of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(25)
<223>  CfTPS14_NcoI_pmF

<400>  31
ttacgccatg gcttccctgg aagtt                                             25


<210>  32
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bri 067 reverse primer for E. coli expression of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(27)
<223>  CfTPS14_XhoI_R

<400>  32
actcaactcg agttctaaga caagagg                                           27


<210>  33
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB156 forward primer for tobacco expression of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(33)
<223>  CfTPS1 (f)

<400>  33
ggcttaauat ggggtctcta tccactatga acc                                    33


<210>  34
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB157 reverse primer for tobacco expression of CfTPS1


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CfTPS1 (rc)

<400>  34
ggtttaautc aggcgactgg ttcgaa                                            26


<210>  35
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB158 forward primer for tobacco expression of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(34)
<223>  CfTPS2 (f)

<400>  35
ggcttaauat gaaaatgttg atgatcaaaa gtca                                   34


<210>  36
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB159 reverse primer for tobacco expression of CfTPS2


<220>
<221>  primer_bind
<222>  (1)..(35)
<223>  CfTPS2 (rc)

<400>  36
ggtttaautc agaccactgg ttcaaatagt acttg                                  35


<210>  37
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB178 forward primer for tobacco expression of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(24)
<223>  CfTPS3 (f)

<400>  37
ggcttaauat gtcgtccctc gccg                                              24


<210>  38
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB179 reverse primer for tobacco expression of CfTPS3


<220>
<221>  primer_bind
<222>  (1)..(35)
<223>  CfTPS3 (rc)

<400>  38
ggtttaauct agttgctgac acaactcatt ttttc                                  35


<210>  39
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB180 forward primer for tobacco expression of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  CfTPS4 (f)

<400>  39
ggcttaauat gtcaatcacc atcaaccttc g                                      31


<210>  40
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB181 reverse primer for tobacco expression of CfTPS4


<220>
<221>  primer_bind
<222>  (1)..(32)
<223>  CfTPS4 (rc)

<400>  40
ggtttaautt agttagcagg tggagggtga at                                     32


<210>  41
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB160 forward primer for tobacco expression of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  CfTPS14 (f)

<400>  41
ggcttaauat gtctctcccg ctctctactt g                                      31


<210>  42
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oSSB161 reverse primer for tobacco expression of CfTPS14


<220>
<221>  primer_bind
<222>  (1)..(41)
<223>  CfTPS14 (rc)

<400>  42
ggtttaautt attctaagac aagaggttga taaataattg c                           41


<210>  43
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS1 forward primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  CfTPS1.for

<400>  43
tagtctggaa gggctggaga at                                                22


<210>  44
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS1 reverse primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(24)
<223>  CfTPS1.rev

<400>  44
ttggtagcat ttaggatcac gagt                                              24


<210>  45
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS2 forward primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(28)
<223>  CfTPS2.for

<400>  45
gacatattat cgcactatga atacaccg                                          28


<210>  46
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS2 reverse primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(29)
<223>  CfTPS2.rev

<400>  46
ctaacttcac caatgtttgt atttcgagc                                         29


<210>  47
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS3 forward primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(29)
<223>  CfTPS3.for

<400>  47
catgcagaat tggttgttat ttgtactca                                         29


<210>  48
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS3 reverse primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(27)
<223>  CfTPS3.rev

<400>  48
tttctccact tgcattatta gcttcag                                           27


<210>  49
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS4 forward primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(25)
<223>  CfTPS4.for

<400>  49
aacggaaaga aaatacagga aacgc                                             25


<210>  50
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS4 reverse primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CfTPS4.rev

<400>  50
cagccaaata tttcgctttt gctatg                                            26


<210>  51
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS14 forward primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(27)
<223>  CfTPS14 (f)

<400>  51
atgcatatgt atcatttgct ctagggc                                           27


<210>  52
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTPS14 reverse primer for qPCR


<220>
<221>  primer_bind
<222>  (1)..(30)
<223>  CfTPS14 .rev

<400>  52
ggatttgaat agattgtggt agtcagcatg                                        30


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfEF1a forward primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  CfEF1a (f)

<400>  53
tgcatcacga ggctctccag                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfEF1a reverse primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  CfEF1a (rc)

<400>  54
ggcaacaaac ccacgcttca                                                   20


<210>  55
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfH3 forward primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(23)
<223>  CfH3 (f)

<400>  55
gagattcgca agtaccagaa gag                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfH3 reverse primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(23)
<223>  CfH3 (rc)

<400>  56
aatcgcagat cagtcttgaa gtc                                               23


<210>  57
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTIF4a forward primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  CfTIF4a (f)

<400>  57
ctatgatctg ccaactcagc c                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CfTIF4a reverse primer for qPCR reference


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  CfTIF4a (rc)

<400>  58
ccttggtcac gaagtttatg g                                                 21


<210>  59
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gCfTIF4a forward primer for qPCR gDNA check


<220>
<221>  primer_bind
<222>  (1)..(23)
<223>  gCfTIF4a (f)

<400>  59
tttgacatgy tgagaaggca gtc                                               23


<210>  60
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gCfTIF4a reverse primer for qPCR gDNA check


<220>
<221>  primer_bind
<222>  (1)..(21)
<223>  gCfTIF4a (rc)

<400>  60
aacatagaac tgcttgatac c                                                 21


<210>  61
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gCfEF1a forward primer for qPCR gDNA check


<220>
<221>  primer_bind
<222>  (1)..(23)
<223>  gCfEF1a (f)

<400>  61
tactactgca ctgtcattga tgc                                               23


<210>  62
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gCfEF1a reverse primer for qPCR gDNA check


<220>
<221>  primer_bind
<222>  (1)..(22)
<223>  gCfEF1a (rc)

<400>  62
tggacctctc aatcatgttg tc                                                22


<210>  63
<211>  1710
<212>  DNA
<213>  Unknown

<220>
<223>  CfTPS3 codon optimised for E. coli


<220>
<221>  CfTPS3_co
<222>  (1)..(1710)
<223>  CfTPS3 from Coleus forskohlii, gene optimised

<400>  63
atgggcatta ccagcaagtc ctccgcagca gtcaaatgta gcctgaccac gccgaccgac       60

ctgatgggca agattaaaga agttttcaat cgtgaagtgg ataccagccc ggcagcaatg      120

accacgcaca gtacggacat cccgtccaac ctgtgcatta tcgataccct gcaacgtctg      180

ggcatcgacc aatattttca gtctgaaatt gatgcagttc tgcatgacac ctaccgcctg      240

tggcagctga aaaagaaaga tatctttagt gacatcacca cgcacgcgat ggccttccgt      300

ctgctgcgtg tcaaaggtta tgaagtggcg agcgatgaac tggcaccgta cgctgaccaa      360

gaacgtatca atctgcagac cattgatgtc ccgacggtgg ttgaactgta tcgtgcagct      420

caggaacgcc tgaccgaaga agatagtacg ctggaaaagc tgtacgtttg gaccagcgcg      480

tttctgaaac agcaactgct gacggatgcc attccggaca agaaactgca taagcaggtt      540

gaatattacc tgaaaaacta tcacggcatc ctggatcgca tgggtgtccg tcgcaatctg      600

gatctgtatg acattagcca ttacaagtct ctgaaagcgg cccaccgttt ctacaacctg      660

tcaaatgaag atatcctggc atttgctcgc caagacttca acatttcgca ggcacaacat      720

cagaaagaac tgcagcaact gcagcgttgg tatgctgatt gtcgcctgga caccctgaaa      780

tttggccgtg atgtcgtgcg catcggtaat ttcctgacga gcgccatgat tggcgatccg      840

gaactgtctg acctgcgtct ggcgtttgcc aaacatatcg ttctggtcac ccgcattgat      900

gactttttcg atcacggcgg tccgaaggaa gaaagctatg aaatcctgga actggtgaaa      960

gaatggaagg aaaaaccggc gggcgaatat gtctctgaag aagtggaaat cctgtttacc     1020

gccgtttaca acacggtcaa tgaactggcg gaaatggccc acattgaaca gggtcgtagt     1080

gtgaaggatc tgctggtgaa actgtgggtt gaaatcctgt ccgttttccg cattgaactg     1140

gatacctgga cgaacgacac cgcactgacg ctggaagaat atctgagtca gtcctgggtg     1200

tcaattggct gccgcatttg tatcctgatt tcgatgcaat ttcagggtgt taaactgtca     1260

gatgaaatgc tgcagtcgga agaatgcacc gacctgtgtc gttacgtgag catggttgat     1320

cgcctgctga atgacgtcca aaccttcgaa aaggaacgta aagaaaacac gggcaattca     1380

gtgtcgctgc tgcaggcagc tcataaagat gaacgcgtta tcaacgaaga agaagcgtgc     1440

attaaggtca aagaactggc tgaatataat cgtcgcaagc tgatgcagat cgtgtacaaa     1500

accggtacga tttttccgcg taagtgtaaa gacctgtttc tgaaagcgtg ccgcattggc     1560

tgttatctgt acagctctgg tgatgaattt accagcccgc agcaaatgat ggaagacatg     1620

aaatctctgg tttatgaacc gctgccgatt agcccgccgg aagccaacaa tgcgtcaggt     1680

gaaaagatgt cgtgtgtctc aaacctcgag                                      1710


