               SEQUENCE LISTING

<110> ARSANIS Biosciences GmbH

<120> ANTIBODIES DIRECTED AGAINST THE LUKGH (LUKAB) TOXIN OF STAPHYLOCOCCUS AUREUS AND ANTIBODY SEQUENCES

<130> AR008P

<160> 188

<170> BiSSAP 1.3

<210> 1
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 1
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 2
Gly Ser Ile Val Asn Gly Met Tyr Tyr Trp Ser 
1               5                   10      

<210> 3
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 3
Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 4
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 4
Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 5
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 6
Ala Arg Asp Val Gly Arg Trp Phe Gly Asn Ile 
1               5                   10      

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 7
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 8
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 8
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 9
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 10
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 11
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 12
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 12
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 13
Gln Gln Arg Tyr Val Met Pro Pro Thr 
1               5                   

<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 14
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 15
Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10      

<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 16
Asp Ser Ser Asn Arg Ala Thr 
1               5           

<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 17
Gln Gln Arg Phe Asn Met Pro Pro Thr 
1               5                   

<210> 18
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 19
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 20
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 21
Asp Ser Ser Asn Arg Ala Thr 
1               5           

<210> 22
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 22
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 23
Gln Gln Tyr Asp Tyr Leu Pro Pro Thr 
1               5                   

<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 24
Gln Gln Val Tyr Asp Leu Pro Pro Thr 
1               5                   

<210> 25
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 26
Gly Thr Phe Ser Ala Tyr Glu Ile Ser 
1               5                   

<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 27
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 28
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 28
Ser Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 29
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 29
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 30
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 30
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
1               5                   10                  15      
Phe Asp Tyr 
            

<210> 31
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 31
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 32
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 33
Gly Ala Ser Ser Leu Gln Ser 
1               5           

<210> 34
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 34
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 35
Gln Gln Ala Tyr Tyr Pro Pro Trp Thr 
1               5                   

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 36
Gly Thr Phe Ser Ser Tyr Ser Ile Ser 
1               5                   

<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 37
Ser Ile Ile Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 38
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   

<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 39
Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 40
Ser Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 41
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 42
Gln Gln Ala Tyr Thr Pro Pro Trp Thr 
1               5                   

<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 43
Gln Gln Ala Tyr Thr Pro Pro Trp Thr 
1               5                   

<210> 44
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 44
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 45
Gln Gln Ser Tyr Tyr Pro Pro Trp Thr 
1               5                   

<210> 46
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      

<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 47
Phe Thr Phe Tyr Asp Tyr Asn Met His 
1               5                   

<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 48
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 49
Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 50
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 50
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
            20                  25                  30  

<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 51
Ala Lys Ala Gln Lys Gly Thr Ala Phe Asp Ile 
1               5                   10      

<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 52
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 53
Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      

<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 54
Gln Gln Tyr Pro Val Tyr Pro Pro Thr 
1               5                   

<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 55
Phe Thr Phe Ala Asp Tyr Asn Met His 
1               5                   

<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 56
Gly Ile Ser Trp Asn Ser Gly Leu Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 57
Phe Thr Phe Gly Asp Tyr Asn Met His 
1               5                   

<210> 58
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 58
Gly Ile Ser Trp Asn Ser Gly Met Ser Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 59
Phe Thr Phe Asp Leu Phe Ala Met His 
1               5                   

<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 60
Gly Ile Thr Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 61
Phe Thr Phe Ala Glu Tyr Ala Met His 
1               5                   

<210> 62
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 62
Gly Ile Thr Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 63
Phe Thr Phe Asp Ser Tyr Asn Met His 
1               5                   

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 64
Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   

<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 65
Gly Ile Ser Trp Asn Ser Gly Ala Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 66
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 66
Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 67
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 67
Gln Ala Ser Gln Asp Ile Ala Asn Tyr Leu Asn 
1               5                   10      

<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 68
Gln Gln Tyr Pro Thr Tyr Pro Pro Thr 
1               5                   

<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 69
Gln Gln Tyr Pro Ile Tyr Pro Pro Thr 
1               5                   

<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 70
Gln Gln Leu Pro Tyr Leu Pro Phe Thr 
1               5                   

<210> 71
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 71
Gly Ser Ile Ser Ser Gly Trp Tyr Tyr Trp Ser 
1               5                   10      

<210> 72
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 72
Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 73
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 73
Ala Arg Glu Arg Gly Met His Tyr Met Asp Val 
1               5                   10      

<210> 74
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 74
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 75
Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asn 
1               5                   10      

<210> 76
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 76
Gln Gln Gln Phe Asp Pro Pro Phe Thr 
1               5                   

<210> 77
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 77
Gly Ser Ile Ser Ser Gly His Tyr Tyr Trp Gly 
1               5                   10      

<210> 78
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 78
Asn Ile Tyr Gly Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 79
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 79
Gly Ser Ile Glu Ser Gly Phe Tyr Tyr Trp Ser 
1               5                   10      

<210> 80
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 80
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 81
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 81
Gly Ser Ile Ser Ser Ser Gly Tyr Tyr Trp Val 
1               5                   10      

<210> 82
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 82
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 83
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 83
Gly Ser Ile Ser Ser Gly Ser Tyr Tyr Trp Asp 
1               5                   10      

<210> 84
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 84
Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 85
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 85
Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 
1               5                   10      

<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 86
Gln Gln Gln Tyr Leu Pro Pro Phe Thr 
1               5                   

<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 87
Gly Thr Phe Trp Ser Gly Ala Ile Ser 
1               5                   

<210> 88
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 88
Gly Ile Ile Pro Ile Glu Gly Pro Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 89
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 89
Ala Arg Gly Ile Val Ala Ala Asp His Leu Tyr Phe Asp Leu 
1               5                   10                  

<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 90
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 91
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 91
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys 
            20              

<210> 92
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 92
Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      



<210> 93
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 93
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 94
Leu Gly Ser Asn Arg Ala Ser 
1               5           

<210> 95
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 95
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          



<210> 96
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 96
Met Gln Ala Leu Gln Gly Leu Thr 
1               5               

<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 97
Gly Thr Phe Ser Leu Tyr Ala Ile Ser 
1               5                   

<210> 98
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 98
Gly Ile Ile Pro Ile Asp Gly Pro Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 99
Gly Thr Phe Trp Glu Tyr Ala Ile Ser 
1               5                   

<210> 100
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 100
Gly Ile Ile Pro Ile Glu Gly Asp Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 101
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 101
Gly Thr Phe Ser Asn Tyr Ala Ile Ser 
1               5                   

<210> 102
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 102
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 103
Met Gln Ala Lys Gln Gly Leu Thr 
1               5               

<210> 104
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 104
Gly Thr Phe Ser Ser Trp Ala Ile Ser 
1               5                   

<210> 105
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 105
Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 106
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 106
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val 
1               5                   10                  

<210> 107
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 107
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 108
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 108
Met Gln Ala Lys Arg Leu Phe Thr 
1               5               

<210> 109
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 109
Gly Ile Ile Pro Ile Phe Gly Pro Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 110
Gly Thr Phe Ser Asn Trp Ala Ile Ser 
1               5                   

<210> 111
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 111
Gly Ile Ile Pro Ile Phe Gly Ser Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 112
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 112
Gly Thr Phe Gly Ser Met Ala Ile Ser 
1               5                   

<210> 113
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 113
Gly Ile Ile Pro Ile Phe Gly Pro Ala Val Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 114
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 114
Gly Thr Ile Trp Ser Glu Ala Ile Ser 
1               5                   

<210> 115
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 115
Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 116
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 116
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      



<210> 117
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 117
Leu Ala Ser Asn Arg Ala Ser 
1               5           

<210> 118
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 118
Met Gln Ala Arg Arg Leu Phe Thr 
1               5               

<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 119
Gly Thr Phe Lys Ser Trp Ala Ile Ser 
1               5                   

<210> 120
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 120
Gly Thr Phe Trp Ser Trp Ala Ile Ser 
1               5                   

<210> 121
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 121
Gly Ile Ile Pro Thr Phe Gly Glu Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 122
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 122
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Phe 
1               5                   10                  15  

<210> 123
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 123
Met Gln Ala Arg Gln Leu Phe Thr 
1               5               

<210> 124
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 124
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
            20                  25      

<210> 125
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 125
Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly 
1               5                   10  

<210> 126
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 126
Thr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 127
Ala Arg Thr Trp Ser Ser Met Asp Val 
1               5                   

<210> 128
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 128
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 129
Gln Gln Ile Tyr Leu His Pro Ile Thr 
1               5                   

<210> 130
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 130
Gln Gln Ile Tyr Ser His Pro Ile Thr 
1               5                   

<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 131
Gln Gln Ile Phe Ser His Pro Ile Thr 
1               5                   

<210> 132
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 132
Gln Gln Val Tyr Ser His Pro Ile Thr 
1               5                   

<210> 133
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 133
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      

<210> 134
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 134
Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   

<210> 135
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 135
Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 136
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 136
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 137
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 137
Ala Lys Ser Leu Arg Tyr Gly Tyr Ala Phe Asp Leu 
1               5                   10          

<210> 138
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 138
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 139
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 139
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr 
1               5                   10                  15  

<210> 140
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 140
Met Gln Ala Lys Gln Gly Ile Thr 
1               5               

<210> 141
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 141
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 142
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 142
Met Gln Ala Arg Gln Gly Ile Thr 
1               5               

<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 143
Met Gln Ala Arg Gln Gly Leu Thr 
1               5               

<210> 144
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 144
Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 145
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 145
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 146
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 146
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 147
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 147
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Val Asn Gly 
            20                  25                  30          
Met Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Val Gly Arg Trp Phe Gly Asn Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 148
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 148
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Val Met Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 149
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 149
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          
Glu Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ser Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 150
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 150
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 151
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 151
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 152
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 152
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 153
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 153
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 154
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 154
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 155
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 155
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Asp Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ala Gln Lys Gly Thr Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 156
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 156
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Pro Val Tyr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 157
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 157
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Trp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 158
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 158
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 159
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 159
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Ser Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 160
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 160
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 161
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 161
Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Ser Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             



<210> 162
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 162
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 163
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 163
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Trp Ser Gly 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Glu Gly Pro Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ile Val Ala Ala Asp His Leu Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         
Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 164
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 164
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Leu Gln Gly Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 165
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 165
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Trp 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 166
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 166
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Lys Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 167
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 167
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Trp 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly 
    450 

<210> 168
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 168
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Lys Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 169
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 169
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Trp Ser Glu 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 170
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 170
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Arg Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 171
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 171
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Trp Ser Glu 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly 
    450 

<210> 172
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 172
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Arg Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 173
<211> 972
<212> DNA
<213> Staphylococcus aureus

<400> 173
aactcggctc ataaagatag tcaggatcaa aataaaaaag aacacgtgga taaatcacaa      60

cagaaagata aacgcaatgt caccaataaa gataaaaata gcaccgcacc ggatgacatt     120

ggcaaaaacg gtaaaatcac caaacgtacc gaaacggtgt atgatgaaaa aacgaatatt     180

ctgcagaacc tgcaatttga tttcatcgat gacccgacct acgacaaaaa tgtgctgctg     240

gttaaaaaac agggcagcat tcattctaac ctgaaattcg aaagtcacaa agaagagaaa     300

aactccaact ggctgaaata tccgtcagaa taccatgtcg atttccaggt gaaacgtaat     360

cgcaaaaccg aaattctgga ccaactgccg aaaaacaaaa tcagtaccgc caaagttgat     420

agtacgtttt cctatagctc tggcggtaaa ttcgactcta ccaaaggcat cggtcgtacg     480

agttccaact catactcgaa aaccatctcg tacaaccagc aaaactacga tacgatcgca     540

agcggcaaaa acaataactg gcatgttcac tggtctgtca ttgctaacga tctgaaatat     600

ggcggtgaag ttaaaaatcg caacgacgaa ctgctgtttt accgtaatac ccgcatcgcg     660

acggtcgaaa acccggaact gtcattcgcg tcgaaatatc gttacccggc cctggtgcgc     720

tccggtttta atccggaatt cctgacctac ctgagcaacg aaaaatctaa cgaaaaaacg     780

cagttcgaag tcacctatac gcgtaatcaa gatattctga aaaaccgtcc gggcattcac     840

tacgcaccgc cgatcctgga gaaaaacaaa gatggtcagc gcctgatcgt gacctatgaa     900

gttgactgga aaaacaaaac cgtgaaagtg gtggacaaat actcggacga caataaaccg     960

tacaaagaag gt                                                         972


<210> 174
<211> 324
<212> PRT
<213> Staphylococcus aureus

<400> 174
Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      
Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          
Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              
Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  
Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  
Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      
Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         
Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             
Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 
Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 
Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     
Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         
Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             
Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 
Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 
Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     
Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         
Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             
Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 
Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 
Tyr Lys Glu Gly 
                

<210> 175
<211> 927
<212> DNA
<213> Staphylococcus aureus

<400> 175
aaaatcaaca gcgaaatcaa acaagtcagc gaaaaaaatc tggatggcga tacgaaaatg      60

tacacgcgca cggcaaccac gagcgattcg cagaaaaaca tcacccagag cctgcaattt     120

aatttcctga ccgaaccgaa ctacgataaa gaaacggtgt tcatcaaagc aaaaggcacc     180

atcggctcag gtctgcgtat tctggacccg aatggctact ggaactcgac cctgcgctgg     240

ccgggtagct attctgtgag tattcagaat gttgatgaca acaataacac caacgttacg     300

gattttgctc cgaaaaatca agatgaaagc cgtgaagtca aatataccta cggctataaa     360

acgggcggtg atttctctat caatcgcggc ggtctgaccg gtaatattac gaaagaatcg     420

aactatagcg aaaccatctc ctaccagcaa ccgtcatatc gtaccctgct ggatcagtcc     480

acgtcacata aaggcgttgg ttggaaagtc gaagcgcacc tgatcaataa catgggccat     540

gatcacaccc gtcaactgac gaatgatagc gacaaccgca cgaaatctga aatttttagt     600

ctgacccgca atggtaacct gtgggcgaaa gataacttca cgccgaaaga caaaatgccg     660

gtcaccgtgt ccgaaggctt taatccggaa ttcctggccg ttatgtctca tgataaaaaa     720

gacaaaggta aaagtcagtt cgtggttcac tacaaacgtt ccatggatga attcaaaatc     780

gactggaacc gccatggctt ctggggttac tggagcggtg aaaaccacgt cgataaaaaa     840

gaagaaaaac tgtctgcact gtatgaagtg gactggaaaa cccacaatgt caaattcgtg     900

aaagttctga atgataatga aaaaaaa                                         927


<210> 176
<211> 309
<212> PRT
<213> Staphylococcus aureus

<400> 176
Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      
Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          
Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              
Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  
Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  
Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      
Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         
Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             
Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 
Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 
Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     
Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         
Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             
Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 
Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 
Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     
Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         
Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             
Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 
Asp Asn Glu Lys Lys 
305                 

<210> 177
<211> 966
<212> DNA
<213> Staphylococcus aureus

<400> 177
gcaaacaagg actcccagga ccagaccaaa aaagaacacg tcgataaagc acagcagaaa      60

gaaaagcgta atgtcaacga taaagataaa aataccccgg gcccggatga cattggcaaa     120

aacggcaagg ttaccaaacg taccgtcagt gaatatgaca aagaaaccaa tattctgcag     180

aacctgcaat ttgatttcat cgatgacccg acgtacgaca aaaatgtgct gctggttaaa     240

aagcaaggta gtatccattc caacctgaag tttgaaagcc accgtaatga aaccaacgcg     300

agttggctga aatatccgtc cgaataccat gtcgatttcc aggtgcaacg caatccgaaa     360

acggaaattc tggaccagct gccgaaaaac aagatctcaa ccgcaaaagt ggattcgacg     420

tttagttatt ccctgggcgg taaattcgac agcaccaaag gcattggtcg caccagcagc     480

aacagctact cgaagagcat ctcttacaac cagcaaaact acgataccat cgcaagcggc     540

aaaaacaata accgtcatgt tcactggtct gtggttgcta atgatctgaa gtatggtaac     600

gaaatcaaaa atcgcaacga cgaatttctg ttctaccgta atacccgcct gagtacggtc     660

gaaaacccgg aactgtcatt tgcgtcgaaa tatcgttacc cggccctggt tcgctccggc     720

tttaatccgg aatttctgac ctacatcagc aacgaaaagt ctaacgaaaa gacgcgtttc     780

gaagtgacct atacgcgcaa tcaggatatc ctgaaaaaca agccgggcat tcactacggt     840

cagccgatcc tggaacaaaa caaagatggc cagcgtttta ttgtcgtgta tgaagtggac     900

tggaaaaata agaccgttaa ggttgtcgaa aaatattctg atcagaacaa gccgtacaaa     960

gaaggt                                                                966


<210> 178
<211> 322
<212> PRT
<213> Staphylococcus aureus

<400> 178
Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys 
1               5                   10                  15      
Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr 
            20                  25                  30          
Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr 
        35                  40                  45              
Val Ser Glu Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu Gln Phe 
    50                  55                  60                  
Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys 
65                  70                  75                  80  
Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Arg Asn 
                85                  90                  95      
Glu Thr Asn Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
            100                 105                 110         
Phe Gln Val Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro 
        115                 120                 125             
Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser 
    130                 135                 140                 
Leu Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser 
145                 150                 155                 160 
Asn Ser Tyr Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr 
                165                 170                 175     
Ile Ala Ser Gly Lys Asn Asn Asn Arg His Val His Trp Ser Val Val 
            180                 185                 190         
Ala Asn Asp Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn Asp Glu 
        195                 200                 205             
Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu 
    210                 215                 220                 
Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly 
225                 230                 235                 240 
Phe Asn Pro Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser Asn Glu 
                245                 250                 255     
Lys Thr Arg Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys 
            260                 265                 270         
Asn Lys Pro Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln Asn Lys 
        275                 280                 285             
Asp Gly Gln Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys Asn Lys 
    290                 295                 300                 
Thr Val Lys Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro Tyr Lys 
305                 310                 315                 320 
Glu Gly 
        

<210> 179
<211> 945
<212> DNA
<213> Staphylococcus aureus

<400> 179
gcaagctcgt atgcggaaat caaaagcaag atcaccaccg tctcagaaaa gaacctggat      60

ggcgacacca agatgtacac ccgtaccgcg accacgagcg atacggaaaa gaaaattagc     120

cagtctctgc aatttaattt cctgaccgaa ccgaactacg acaaagaaac ggtgtttatt     180

aaagccaagg gcaccatcgg cagcggtctg aaaattctga atccgaacgg ctactggaac     240

agcaccctgc gttggccggg tagttattcc gtttcaattc agaacgtcga tgacaacaat     300

aactcaacca atgtcacgga ttttgcaccg aaaaaccaag acgaatcgcg tgaagtgaaa     360

tatacctacg gctataagac gggcggtgat ttcagtatca atcgcggcgg tctgaccggt     420

aacatcacga aggaaaagaa ctactcggaa accatcagct accagcaacc gtcttatcgt     480

accctgattg atcagccgac cacgaataaa ggcgtcgcgt ggaaggtgga agcccatagc     540

atcaataaca tgggtcatga tcacacccgt caactgacga acgactctga tgaccgcgtg     600

aaatctgaaa tttttagtct gacccgcaat ggcaacctgt gggcaaaaga taatttcacg     660

ccgaaaaaca agatgccggt gaccgtttcc gaaggcttta atccggaatt tctggctgtt     720

atgtcccatg ataaaaacga caaaggtaag tcacgtttca tcgtccacta taaacgctcg     780

atggatgact ttaaactgga ttggaataag catggcttct ggggttactg gagtggtgaa     840

aaccacgttg accagaaaga agaaaagctg tccgccctgt atgaagtgga ttggaaaacg     900

cacgacgtta aactgattaa gaccatcaac gataaagaac agaag                     945


<210> 180
<211> 315
<212> PRT
<213> Staphylococcus aureus

<400> 180
Ala Ser Ser Tyr Ala Glu Ile Lys Ser Lys Ile Thr Thr Val Ser Glu 
1               5                   10                  15      
Lys Asn Leu Asp Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr 
            20                  25                  30          
Ser Asp Thr Glu Lys Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu 
        35                  40                  45              
Thr Glu Pro Asn Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly 
    50                  55                  60                  
Thr Ile Gly Ser Gly Leu Lys Ile Leu Asn Pro Asn Gly Tyr Trp Asn 
65                  70                  75                  80  
Ser Thr Leu Arg Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val 
                85                  90                  95      
Asp Asp Asn Asn Asn Ser Thr Asn Val Thr Asp Phe Ala Pro Lys Asn 
            100                 105                 110         
Gln Asp Glu Ser Arg Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly 
        115                 120                 125             
Gly Asp Phe Ser Ile Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys 
    130                 135                 140                 
Glu Lys Asn Tyr Ser Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg 
145                 150                 155                 160 
Thr Leu Ile Asp Gln Pro Thr Thr Asn Lys Gly Val Ala Trp Lys Val 
                165                 170                 175     
Glu Ala His Ser Ile Asn Asn Met Gly His Asp His Thr Arg Gln Leu 
            180                 185                 190         
Thr Asn Asp Ser Asp Asp Arg Val Lys Ser Glu Ile Phe Ser Leu Thr 
        195                 200                 205             
Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys 
    210                 215                 220                 
Met Pro Val Thr Val Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val 
225                 230                 235                 240 
Met Ser His Asp Lys Asn Asp Lys Gly Lys Ser Arg Phe Ile Val His 
                245                 250                 255     
Tyr Lys Arg Ser Met Asp Asp Phe Lys Leu Asp Trp Asn Lys His Gly 
            260                 265                 270         
Phe Trp Gly Tyr Trp Ser Gly Glu Asn His Val Asp Gln Lys Glu Glu 
        275                 280                 285             
Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp Lys Thr His Asp Val Lys 
    290                 295                 300                 
Leu Ile Lys Thr Ile Asn Asp Lys Glu Gln Lys 
305                 310                 315 

<210> 181
<211> 954
<212> DNA
<213> Staphylococcus aureus

<400> 181
gactcacagg accaaaacaa aaaggaacac gttgataagg cacagcagaa agacaagcaa      60

gatagcacca agaaaggcaa aaacgttgcg gccccggatg acgtcggcaa aaacggcaag     120

gtgaccaaac gtacggaaag cgaatacgat gaaaagacca acatcctgca gaacctggaa     180

tttaatttca tcgatgaccc gacctacgat aaagacgtcc tgctggtgaa aaagcaaggc     240

agtattcatt ccaacctgaa gttcgaaagt cacaaagaag aaaagaacag cacctggctg     300

aaatatccgt cagaatacca tgttgatttc caggtcaagc gtaacccgaa aaccgaaatt     360

ctggaccaac tgccgaaaaa taagatcagt acggcaaaag tggattcaac cttttcgtat     420

acgctgggcg gtaaattcga ctccattaaa ggcatcggtc gcaatagctc taacagctat     480

tctcagacca tttcgtataa tcagcaaaac tacgatacga tcgcgagcgg caaaaacaat     540

aactggcatg tgcactggtc tgttattgcc aacgatctga agtatggcgg tgaagttaaa     600

aatcgtaacg acgaatttct gttctaccgt aacacccgca cgagttccgt tgataatccg     660

gaatcatcgt ttgcagctaa atatcgttac ccggcactgg tccgcagtgg ttttaatccg     720

gaatttctga cctatctgag caacgaaaag tctaatgaaa aaacgcagtt tgaagtgacc     780

tatacgcgta accaagatat cctgaaaaat agcccgggcc tgcattacgc tccgccgatt     840

ctggaaaaga acaaggttgg tcaccgcttt atcgtcacct atgaagtgga ttggaaaaat     900

aagacggtga aggtggttga caaatactct gatgaccagc cgttccgcga aggt           954


<210> 182
<211> 318
<212> PRT
<213> Staphylococcus aureus

<400> 182
Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ala Gln Gln 
1               5                   10                  15      
Lys Asp Lys Gln Asp Ser Thr Lys Lys Gly Lys Asn Val Ala Ala Pro 
            20                  25                  30          
Asp Asp Val Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Glu Ser Glu 
        35                  40                  45              
Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Glu Phe Asn Phe Ile 
    50                  55                  60                  
Asp Asp Pro Thr Tyr Asp Lys Asp Val Leu Leu Val Lys Lys Gln Gly 
65                  70                  75                  80  
Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
                85                  90                  95      
Ser Thr Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
            100                 105                 110         
Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
        115                 120                 125             
Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Thr Leu Gly Gly 
    130                 135                 140                 
Lys Phe Asp Ser Ile Lys Gly Ile Gly Arg Asn Ser Ser Asn Ser Tyr 
145                 150                 155                 160 
Ser Gln Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
                165                 170                 175     
Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
            180                 185                 190         
Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Phe Leu Phe 
        195                 200                 205             
Tyr Arg Asn Thr Arg Thr Ser Ser Val Asp Asn Pro Glu Ser Ser Phe 
    210                 215                 220                 
Ala Ala Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
225                 230                 235                 240 
Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
                245                 250                 255     
Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Ser Pro 
            260                 265                 270         
Gly Leu His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Val Gly His 
        275                 280                 285             
Arg Phe Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
    290                 295                 300                 
Val Val Asp Lys Tyr Ser Asp Asp Gln Pro Phe Arg Glu Gly 
305                 310                 315             

<210> 183
<211> 927
<212> DNA
<213> Staphylococcus aureus

<400> 183
aaaatcaaat cggaaatcac gcaagttagc gaacagaata tcgacggcaa tacgaagatg      60

tttacccgca cggcaacgac ctcggatagc cagaaaaaga tcagccagtc tctgcaattt     120

aacttcctga ccgaaccgaa ctacgacaag gaaacggtgt tcatcaaggc aaagggcacc     180

atcggctctg gtctgaaaat tctggacccg aacggctact ggaatagtac cctgcgttgg     240

ccgggtagtt attccgtgtc aatccagaac gttgataaca ataccaatac gaaggttacg     300

gattttgccc cgaaaaacca agacgaaacc cgcgaagtca agtataccta cggctataaa     360

acgggcggtg atttctcgat tagcccgggc ggtattaccg gtaacatcac gaaagaacgt     420

aattattctg aaaccatcag ttaccagcaa ccgagttatc gcaccctgat tgaccagccg     480

gcgacgaata agggcgttgg ttggaaagtc gaagcccatc tgatcaacaa tatgggccat     540

gatcacaccc gtcaactgac gaacgattcc gacaatcgcg tgggctcaga aatttttacc     600

ctgacgcgta acggtaatct gtgggcgaaa gataacttca cgccgaaaaa taagatgccg     660

gtcaccgtgt ccgaaggctt taacccggaa tttctggccg ttatgtcgca tgataaaaag     720

gacaaaggca agagcaaatt tgtggttcac tataaacgta cgatggatga ctttaaaatc     780

gattggatgc gccatggctt ctggggttac tggaccggta aaaatcacgt tgaccagaag     840

gaagaaaaac tgtctgcact gtatgaagtc gattggaaaa cccacgacgt gaagttcatt     900

aaagctctgg atgacaaaga aaagaaa                                         927


<210> 184
<211> 309
<212> PRT
<213> Staphylococcus aureus

<400> 184
Lys Ile Lys Ser Glu Ile Thr Gln Val Ser Glu Gln Asn Ile Asp Gly 
1               5                   10                  15      
Asn Thr Lys Met Phe Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          
Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              
Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  
Leu Lys Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  
Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asn Asn Thr Asn 
                85                  90                  95      
Thr Lys Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Thr Arg Glu 
            100                 105                 110         
Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Ser 
        115                 120                 125             
Pro Gly Gly Ile Thr Gly Asn Ile Thr Lys Glu Arg Asn Tyr Ser Glu 
    130                 135                 140                 
Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro 
145                 150                 155                 160 
Ala Thr Asn Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     
Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         
Arg Val Gly Ser Glu Ile Phe Thr Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             
Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 
Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 
Asp Lys Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Thr Met Asp 
                245                 250                 255     
Asp Phe Lys Ile Asp Trp Met Arg His Gly Phe Trp Gly Tyr Trp Thr 
            260                 265                 270         
Gly Lys Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             
Glu Val Asp Trp Lys Thr His Asp Val Lys Phe Ile Lys Ala Leu Asp 
    290                 295                 300                 
Asp Lys Glu Lys Lys 
305                 

<210> 185
<211> 966
<212> DNA
<213> Staphylococcus aureus

<400> 185
gccaacaagg acagccagga ccaaaccaag aaggagcacg tggacaaggc ccagcaaaag      60

gagaagcgca acgtgaacga caaggataag aacacacctg gcccggatga tatcggcaag     120

aacggtaagg tgaccaagcg cacagagacc gtttacgacg agaagaccaa catcctgcag     180

aacctgcagt tcgacttcat cgacgacccg acctacgaca agaacatcct gttagtgaaa     240

aagcagggca gcatccacag caacctgaag ttcgaaagcc acaaagagga gaacaacagc     300

agctggctga aataccctag cgagtaccac gtggatttcc aggtgaagcg caaccgtaag     360

accgagatcc tggaccagct gccgaagaac aagatcagta ccgcaaaggt ggacagcacc     420

ttcagttaca acagcggcgg caagtttgat agtgttaagg gcgttggccg cacaagtagc     480

aacagctaca gcaagacaat tagttataac cagcagaact atgacacaat cgccagcggc     540

aagaacaaca actggcacgt gcattggagc gtggtggcaa atgacctgaa atacggcggc     600

gaggtgaaaa atcgcaacga cgagttcctg ttttaccgca caacccgcct gagcaccgtg     660

gagaaccctg agctgagctt tgccagcaag tatcgctatc cggcactggt gcgtagcggc     720

ttcaacccgg agttcctgac ctacctgagt aacgagaaga gcaatgagaa aacacagttc     780

gaggtgacct acacccgcaa ccaggacatc ctgaagaaca aaccgggcat ccactatgcc     840

ccgccgatcc tggagaagaa taaggacggc cagcgcctga ttgtgaccta cgaggtggac     900

tggaagaaca aaaccgtgaa ggtgatcgac aaatacagcg acgacaacaa gccgtataaa     960

gagggg                                                                966


<210> 186
<211> 322
<212> PRT
<213> Staphylococcus aureus

<400> 186
Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys 
1               5                   10                  15      
Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr 
            20                  25                  30          
Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr 
        35                  40                  45              
Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe 
    50                  55                  60                  
Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Ile Leu Leu Val Lys 
65                  70                  75                  80  
Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu 
                85                  90                  95      
Glu Asn Asn Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
            100                 105                 110         
Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro 
        115                 120                 125             
Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Asn 
    130                 135                 140                 
Ser Gly Gly Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr Ser Ser 
145                 150                 155                 160 
Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr 
                165                 170                 175     
Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Val 
            180                 185                 190         
Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu 
        195                 200                 205             
Phe Leu Phe Tyr Arg Thr Thr Arg Leu Ser Thr Val Glu Asn Pro Glu 
    210                 215                 220                 
Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly 
225                 230                 235                 240 
Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu 
                245                 250                 255     
Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys 
            260                 265                 270         
Asn Lys Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys 
        275                 280                 285             
Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys 
    290                 295                 300                 
Thr Val Lys Val Ile Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys 
305                 310                 315                 320 
Glu Gly 
        

<210> 187
<211> 921
<212> DNA
<213> Staphylococcus aureus

<400> 187
aacagcgaga tcaagcaggt gagcgagaaa aacctggacg gcgagaccaa gatgtacaca      60

cgcacagcca ccaccagcga cagccagaaa aacatcaccc agagtctgca gttcaacttc     120

ctgaccgaga agaactatga caaagaaacc gttttcatca aggccaaagg caccatcggc     180

agtggtctgc gcattctgga gccgaacggc tactggaaca gcaccttacg ttggcctggt     240

agttacagcg tgagcatcca gaatgtggac gacaacaaca acaccaacgt gaccgacttc     300

gcaccgaaga atcaggacga gagccgcgag gtgaagtaca cctacggcta caagaccggc     360

ggtgacttta gcatcaacca gggtggcctg accggcaaca tcaccaagga gagcaactac     420

agcgagacca tcagctatca gcaaccgagt taccgcacac tgattgacca gccgacaacc     480

aacaagggcg ttgcctggaa agtggaggcc cacctgatca acaacatggg ccatgaccac     540

acacgtcagc tgaccaacga tagcgatgac cgtgtgaaga gcgagatctt cagcctgacc     600

cgcaacggta atctgtgggc caaggacaac ttcaccccga aaaacaagat gccggtgacc     660

gttagcgaag gcttcaatcc ggagttcctg gccgttatga gccacgacaa gaaggacgag     720

ggcaagagta agttcgtggt gcactacaag cgcagcatgg acgagttcaa gattgactgg     780

aacaagcacg gcttctgggg ctactggagc ggcgagaacc acgtggacaa gaaagaggag     840

aagctgagcg cactgtacga agtggactgg aagacccata acgtgaagtt tattaaggtt     900

ttaaacgata aagagaaaaa a                                               921


<210> 188
<211> 307
<212> PRT
<213> Staphylococcus aureus

<400> 188
Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Glu Thr 
1               5                   10                  15      
Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile 
            20                  25                  30          
Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Lys Asn Tyr Asp Lys 
        35                  40                  45              
Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg 
    50                  55                  60                  
Ile Leu Glu Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly 
65                  70                  75                  80  
Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn 
                85                  90                  95      
Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys 
            100                 105                 110         
Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Gln Gly 
        115                 120                 125             
Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile 
    130                 135                 140                 
Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr 
145                 150                 155                 160 
Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Leu Ile Asn Asn Met 
                165                 170                 175     
Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val 
            180                 185                 190         
Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys 
        195                 200                 205             
Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly 
    210                 215                 220                 
Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu 
225                 230                 235                 240 
Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe 
                245                 250                 255     
Lys Ile Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu 
            260                 265                 270         
Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val 
        275                 280                 285             
Asp Trp Lys Thr His Asn Val Lys Phe Ile Lys Val Leu Asn Asp Lys 
    290                 295                 300                 
Glu Lys Lys 
305         

