                         SEQUENCE LISTING

<110>  Intervet International BV
       Intervet Inc.
       Morsey, Mohamad
       Zhang, Yuanzheng
       Bartels-Morozov, Denise
       Erskine, Jason
       Tarpey, Ian
       Presta, Leonard G
 
<120>  CANINIZED MURINE ANTIBODIES TO HUMAN PD-1

<130>  23706

<150>  61/918,847
<151>  2013-12-20

<150>  62/030,812
<151>  2014-07-30

<150>  61/918,946
<151>  2013-12-20

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  795
<212>  DNA
<213>  Canis familiaris

<400>  1
ctagactccc ctgacaggcc ctggagcccg ctcaccttct ccccggcgca gctcacggtg       60

caggagggag agaacgccac gttcacctgc agcctggccg acatccccga cagcttcgtg      120

ctcaactggt accgcctgag cccccgcaac cagacggaca agctggccgc cttccaggag      180

gaccgcatcg agccgggccg ggacaggcgc ttccgcgtca tgcggctgcc caacgggcgg      240

gacttccaca tgagcatcgt cgctgcgcgc ctcaacgaca gcggcatcta cctgtgcggg      300

gccatctacc tgccccccaa cacacagatc aacgagagtc cccgcgcaga gctctccgtg      360

acggagagaa ccctggagcc ccccacacag agccccagcc ccccacccag actcagcggc      420

cagttgcagg ggctggtcat cggcgtcacg agcgtgctgg tgggtgtcct gctactgctg      480

ctgctgacct gggtcctggc cgctgtcttc cccagggcca cccgaggtgc ctgtgtgtgc      540

gggagcgagg acgagcctct gaaggagggc cccgatgcag cgcccgtctt caccctggac      600

tacggggagc tggacttcca gtggcgagag aagacgccgg agcccccggc gccctgtgcc      660

ccggagcaga ccgagtatgc caccatcgtc ttcccgggca ggccggcgtc cccgggccgc      720

agggcctcgg ccagcagcct gcagggagcc cagcctccga gccccgagga cggacccggc      780

ctgtggcccc tctga                                                       795


<210>  2
<211>  264
<212>  PRT
<213>  Canis familiaris

<400>  2

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala 
1               5                   10                  15      


Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu 
    50                  55                  60                  


Pro Gly Arg Asp Arg Arg Phe Arg Val Met Arg Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu 
            100                 105                 110         


Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro 
        115                 120                 125             


Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly 
    130                 135                 140                 


Leu Val Ile Gly Val Thr Ser Val Leu Val Gly Val Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Trp Val Leu Ala Ala Val Phe Pro Arg Ala Thr Arg Gly 
                165                 170                 175     


Ala Cys Val Cys Gly Ser Glu Asp Glu Pro Leu Lys Glu Gly Pro Asp 
            180                 185                 190         


Ala Ala Pro Val Phe Thr Leu Asp Tyr Gly Glu Leu Asp Phe Gln Trp 
        195                 200                 205             


Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro Cys Ala Pro Glu Gln Thr 
    210                 215                 220                 


Glu Tyr Ala Thr Ile Val Phe Pro Gly Arg Pro Ala Ser Pro Gly Arg 
225                 230                 235                 240 


Arg Ala Ser Ala Ser Ser Leu Gln Gly Ala Gln Pro Pro Ser Pro Glu 
                245                 250                 255     


Asp Gly Pro Gly Leu Trp Pro Leu 
            260                 


<210>  3
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  3
ctggattccc ccgacagacc ctggagccct ctcaccttct cccctgccca gctgaccgtc       60

caggaaggcg agaatgccac cttcacctgc agcctcgccg acatccccga cagcttcgtg      120

ctgaactggt acagactgag ccccaggaac cagaccgaca agctggccgc tttccaggag      180

gacaggatcg aacccggcag ggacaggagg tttagggtca tgaggctgcc caacggcagg      240

gacttccaca tgtccatcgt ggccgccaga ctgaacgact ccggcatcta cctgtgcggc      300

gctatctacc tgccccccaa cacccagatc aacgagagcc ccagggccga actgagcgtg      360

acagagagaa ccctggaacc tcccacccag agcccttccc ctcctcctag actgagcgga      420

cagctgcagg gcctggtg                                                    438


<210>  4
<211>  146
<212>  PRT
<213>  Canis familiaris

<400>  4

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala 
1               5                   10                  15      


Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu 
    50                  55                  60                  


Pro Gly Arg Asp Arg Arg Phe Arg Val Met Arg Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu 
            100                 105                 110         


Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro 
        115                 120                 125             


Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly 
    130                 135                 140                 


Leu Val 
145     


<210>  5
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  5
ctggattccc ccgacagacc ctggagccct ctcaccttct cccctgccca gctgaccgtc       60

caggaaggcg agaatgccac cttcacctgc agcctcgccg acatccccga cagcttcgtg      120

ctgaactggt acagactgag ccccaggaac cagaccgaca agctggccgc tttccaggag      180

gacaggatcg aacccggcag ggacaggagg tttagggtca tgaggctgcc caacggcagg      240

gacttccaca tgtccatcgt ggccgccaga ctgaacgact ccggcatcta cctgtgcggc      300

gctatctacc tgccccccaa cacccagatc aacgagagcc ccagggccga actgagcgtg      360

acagagagaa ccctggaacc tcccacccag agcccttccc ctcctcctag actgagcgga      420

cagctgcagg gcctggtggg taccgacaaa actcacacat gcccaccgtg cccagcacct      480

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      540

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      600

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      660

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      720

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      780

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      840

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      900

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      960

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1020

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1080

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1128


<210>  6
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  6

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala 
1               5                   10                  15      


Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu 
    50                  55                  60                  


Pro Gly Arg Asp Arg Arg Phe Arg Val Met Arg Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu 
            100                 105                 110         


Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro 
        115                 120                 125             


Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly 
    130                 135                 140                 


Leu Val Gly Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  7
<211>  816
<212>  DNA
<213>  Canis familiaris

<400>  7
tttacgatca cagtttctaa ggacctgtat gtggtagagt atggtggcaa tgtgacaatg       60

gaatgcaaat tcccggtgga aaaacagtta aacttgtttg cactaatcgt ctactgggaa      120

atggaggata aaaaaattat acaatttgtg aatggaaagg aagacctgaa agttcagcac      180

agcagctaca gccagagggc tcagctattg aaggaccagc tcttcttggg gaaggctgcg      240

cttcagatca cagatgtgag attgcaggat gcaggggttt actgctgctt gatcggctat      300

ggcggtgctg actacaagcg gattactttg aaagttcatg ccccgtaccg caacatcagc      360

caaagaattt ctgtggatcc tgtcacctct gaacatgaac taatgtgtca ggctgagggt      420

taccctgagg ctgaagtcat ctggacaagc agtgaccacc gagtcctgag tggcaaaacc      480

accatcacta attccaatag ggaagagaag cttttcaatg tgaccagcac gctgaacatc      540

aatgcaacag ctaatgagat tttctactgc acttttcaaa gatcaggtcc tgaggaaaac      600

aatactgccg agttggtcat cccagaacga ctgcccgttc cagcaagtga gaggactcat      660

ttcatgattc tgggaccttt cctgttgctt cttggtgtag tcctggcagt cactttctgt      720

ctaaaaaaac atgggagaat gatggatgtg gaaaaatgtt gcacccgaga taggaactca      780

aagaaacgaa atgatataca atttgaagag acataa                                816


<210>  8
<211>  271
<212>  PRT
<213>  Canis familiaris

<400>  8

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Phe Met Ile Leu 
    210                 215                 220                 


Gly Pro Phe Leu Leu Leu Leu Gly Val Val Leu Ala Val Thr Phe Cys 
225                 230                 235                 240 


Leu Lys Lys His Gly Arg Met Met Asp Val Glu Lys Cys Cys Thr Arg 
                245                 250                 255     


Asp Arg Asn Ser Lys Lys Arg Asn Asp Ile Gln Phe Glu Glu Thr 
            260                 265                 270     


<210>  9
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  9
tttaccatca ccgtgtccaa ggacctgtac gtggtcgagt acggcggcaa tgtgaccatg       60

gagtgcaagt tccccgtgga gaagcagctg aacctgttcg ccctcatcgt gtactgggag      120

atggaggaca agaagatcat ccagttcgtg aacggcaagg aggacctgaa ggtgcagcac      180

tccagctact cccagagagc ccagctgctg aaggaccagc tgttcctggg caaggccgcc      240

ctgcagatca ccgacgtgag actgcaggac gccggcgtgt attgctgcct gatcggctac      300

ggaggcgccg actacaagag gatcaccctg aaggtgcatg caccctacag gaacatcagc      360

cagaggatca gcgtcgatcc cgtgaccagc gagcacgagc tgatgtgcca agccgagggc      420

tatcccgagg ccgaagtgat ctggaccagc agcgaccaca gggtcctgag cggcaagacc      480

accatcacca acagcaacag ggaggagaag ctgttcaacg tgaccagcac cctcaacatc      540

aacgccaccg ccaacgagat cttctactgc accttccaga ggagcggccc cgaagagaac      600

aacaccgccg agctggtgat ccccgagaga ctgcctgtgc ctgccagcga gaggacccac      660


<210>  10
<211>  220
<212>  PRT
<213>  Canis familiaris

<400>  10

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His 
    210                 215                 220 


<210>  11
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  11
tttaccatca ccgtgtccaa ggacctgtac gtggtcgagt acggcggcaa tgtgaccatg       60

gagtgcaagt tccccgtgga gaagcagctg aacctgttcg ccctcatcgt gtactgggag      120

atggaggaca agaagatcat ccagttcgtg aacggcaagg aggacctgaa ggtgcagcac      180

tccagctact cccagagagc ccagctgctg aaggaccagc tgttcctggg caaggccgcc      240

ctgcagatca ccgacgtgag actgcaggac gccggcgtgt attgctgcct gatcggctac      300

ggaggcgccg actacaagag gatcaccctg aaggtgcatg caccctacag gaacatcagc      360

cagaggatca gcgtcgatcc cgtgaccagc gagcacgagc tgatgtgcca agccgagggc      420

tatcccgagg ccgaagtgat ctggaccagc agcgaccaca gggtcctgag cggcaagacc      480

accatcacca acagcaacag ggaggagaag ctgttcaacg tgaccagcac cctcaacatc      540

aacgccaccg ccaacgagat cttctactgc accttccaga ggagcggccc cgaagagaac      600

aacaccgccg agctggtgat ccccgagaga ctgcctgtgc ctgccagcga gaggacccac      660

ggtaccgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaatga                                      1350


<210>  12
<211>  449
<212>  PRT
<213>  Canis familiaris

<400>  12

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Gly Thr Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  13
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  13
agttattatc tgtac                                                        15


<210>  14
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  14

Ser Tyr Tyr Leu Tyr 
1               5   


<210>  15
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  15
ggggttaatc ctagtaatgg tggtactaac ttcagtgaga agttcaag                    48


<210>  16
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  16

Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe Lys 
1               5                   10                  15      


<210>  17
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  17
agggattcta actacgacgg gggctttgac tac                                    33


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  19
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  19
agggccagca aaagtgtcag tacatctggc tttagttatt tgcac                       45


<210>  20
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  20

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Phe Ser Tyr Leu His 
1               5                   10                  15  


<210>  21
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  21
cttgcatcca acctagagtc t                                                 21


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  23
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  23
cagcacagtt gggagcttcc gctcacg                                           27


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln His Ser Trp Glu Leu Pro Leu Thr 
1               5                   


<210>  25
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  25
gaggtgcagc tggtgcagtc cggcggcgat ctggtgaagc ctggaggcag cgtgagactg       60

agctgcgtgg ccagcggcta caccttcacc agctactacc tgtactgggt gaggcaggct      120

cctggcaaag gactgcagtg gatcggcggc gtgaatccta gcaacggcgg caccaacttc      180

agcgagaagt tcaagagcag ggccaccctg agcgtggaca aggccaagaa caccgcctac      240

atgcagctga actccctgag ggccgaggac accgccgtgt actactgcac caggagggac      300

agcaactacg acggcggctt cgactactgg ggacagggaa ccctgctgac cgtgtccagc      360

gcttccacaa cggctccgtc ggtgtttccc ctggcaccta gctgcgggtc gacctcgggt      420

agcacagtgg cgctggcgtg tttggtgtcg ggatactttc ccgagccggt aacggtgtca      480

tggaactcag ggtcacttac atcaggagtc catacttttc cgtccgtgct gcagtcaagc      540

ggcttgcatt cactgtcctc gatggtgacg gtgccttcgt cgaggtggcc cagcgaaacg      600

ttcacttgta acgtagtaca cccggcctcc aacacgaaag tcgataaacc ggtattcaat      660

gagtgcagat gtacagacac ccctccctgt ccggtacccg aaccccttgg agggccgagc      720

gtcctcatct tccctcccaa gccaaaagac atcttgcgca ttacgaggac accagaagtc      780

acgtgcgtag tgcttgatct cggtagagaa gatcccgagg tccagatctc gtggtttgtg      840

gatggaaagg aggtccacac cgcaaagact cagtcgcgcg agcagcagtt caatggcacg      900

tatcgggtcg tgagcgtgct tcctatcgag catcaggact ggctcaccgg gaaggagttc      960

aaatgccggg tcaatcatat cgacctcccg tcaccaatcg agcggaccat ctcgaaggct     1020

agaggaaggg cgcacaaacc ttcggtctat gtgcttcccc catcgcccaa agagctttcc     1080

tcgtcggata cggtgtccat tacatgcttg attaaggact tctatcctcc tgatattgat     1140

gtggaatggc aatcaaacgg acagcaggag ccggaacgca agcaccgaat gaccccaccg     1200

caattggacg aagatggtag ctactttctc tactcaaagc tctcagtcga caaatcccga     1260

tggcagcagg gagatccctt cacttgcgcc gtgatgcacg agacactcca aaatcattac     1320

acggaccttt cgttgagcca ctcgcccgga aag                                  1353


<210>  26
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro 
        195                 200                 205             


Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg Cys 
    210                 215                 220                 


Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala 
        275                 280                 285             


Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met 
            420                 425                 430         


His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  27
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  27
gaggtgcagc tggtgcagtc cggcggcgat ctggtgaagc ctggaggcag cgtgagactg       60

agctgcgtgg ccagcggcta caccttcacc agctactacc tgtactgggt gaggcaggct      120

cctggcaaag gactgcagtg gatcggcggc gtgaatccta gcaacggcgg caccaacttc      180

agcgagaagt tcaagagcag ggccaccctg agcgtggaca aggccaagaa caccgcctac      240

atgcagctga actccctgag ggccgaggac accgccgtgt actactgcac caggagggac      300

agcaactacg acggcggctt cgactactgg ggacagggaa ccctgctgac cgtgtccagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gaccttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcaacg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggcgt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaagtga                  1368


<210>  28
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  29
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  29
gaggtgcagc tggtgcagtc cggcggcgat ctggtgaagc ctggaggcag cgtgagactg       60

agctgcgtgg ccagcggcta caccttcacc agctactacc tgtactgggt gaggcaggct      120

cctggcaaag gactgcagtg gatcggcggc gtgaatccta gcaacggcgg caccaacttc      180

agcgagaagt tcaagagcag ggccaccctg agcgtggaca aggccaagaa caccgcctac      240

atgcagctga actccctgag ggccgaggac accgccgtgt actactgcac caggagggac      300

agcaactacg acggcggctt cgactactgg ggacagggaa ccctgctgac cgtgtccagc      360

gcttcaacca cagcgccgag cgtgttccct ctggcgccgt cgtgcggttc cacctcggga      420

tcaacagtgg ccctcgcctg tctcgtgagc ggatactttc cggagcctgt cacggtgtcg      480

tggaatagcg gatcactcac gtcgggcgtg catacttttc catccgtctt gcaatcgagc      540

ggattgtact cactctcctc aaccgtcact gtcccctcgt cgcgctggcc ctcggagact      600

tttacgtgca atgtagtcca tccggcgagc aacacgaagg tcgacaagcc cgtacccaag      660

gaatcaacat gcaagtgcat ctcgccctgt cccgtccccg aatcccttgg tggcccctca      720

gtgtttatct tccctccgaa gcctaaagac atcttgagaa tcacaagaac accggaaatc      780

acgtgtgtgg tccttgactt gggacgcgag gaccctgagg tacaaatctc gtggtttgtg      840

gacgggaaag aggtgcacac agcaaagaca caaccacgcg agcagcagtt taactcaacg      900

tacagggtag tatccgtact tcccattgaa caccaggatt ggctcaccgg taaagaattc      960

aaatgccgag tgaatcacat cgggcttcct agcccaattg agcggacgat ttccaaagct     1020

aggggtcagg cccaccagcc gagcgtatac gtgttgccgc cctccccgaa ggagctgtca     1080

tcgtcagata cggtaacgtt gacgtgtctg atcaaagatt tctttcctcc cgaaattgat     1140

gtggaatggc aaagcaatgg gcagcccgag cccgagtcaa agtaccatac tactgcacca     1200

cagctggacg aagatggatc gtatttcctc tactcgaaac tgtccgtgga taagtcccgg     1260

tggcagcaag gggacacctt cacttgcgcg gtcatgcacg aggcacttca gaaccactat     1320

acggacttga gcctctcgca ttcgccaggg aag                                  1353


<210>  30
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  30

Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro 
        195                 200                 205             


Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu Ser Thr Cys 
    210                 215                 220                 


Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg 
                245                 250                 255     


Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala 
        275                 280                 285             


Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  31
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  31
gatatcgtcc tgacccagac ccctctgagc ctgtccgtga gccctggaga acccgccagc       60

atcagctgca gggcctccaa gagcgtgagc accagcggct tcagctacct gcactggtac      120

aggcagaagc ccggacagag ccctcagctg ctgatcttcc tggccagcaa cctggagagc      180

ggcgtgcctg acaggtttag cggaagcggc agcggcaccg acttcacact gaggatctcc      240

agggtggaag ccgacgacgc cggagtgtac tactgccagc acagctggga actgcccctg      300

accttcggcc agggcaccaa ggtggagatc aagaggaacg acgctcagcc agccgtgtac      360

ctcttccagc cttcgccgga ccagcttcat acggggtcag cgtcggtggt gtgcctgttg      420

aactcgtttt accccaagga cattaacgtg aagtggaagg tagacggggt aattcaagac      480

actggcattc aagagtccgt cacggaacaa gactcaaaag actcaacgta ttcactgtcg      540

tcaaccttga cgatgtcaag caccgagtat cttagccatg agctgtattc gtgcgagatc      600

acccacaagt ccctcccctc cactcttatc aaatcctttc agcggtcgga atgtcagcgg      660

gtcgat                                                                 666


<210>  32
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  32

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Phe Ser Tyr Leu His Trp Tyr Arg Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Phe Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
            180                 185                 190         


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
        195                 200                 205             


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220         


<210>  33
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  33
gatatcgtcc tgacccagac ccctcctagc ctgtccgtga gccctggaga acccgccagc       60

atcagctgca gggcctccaa gagcgtgagc accagcggct tcagctacct gcactggtac      120

aggcagaagc ccggacagcc tcctcagctg ctgatcttcc tggccagcaa cctggagagc      180

ggcgtgcctg acaggtttag cggaagcggc agcggcaccg acttcacact gaggatctcc      240

agggtggaag ccgacgacgc cggagtgtac tactgccagc acagctggga actgcccctg      300

accttcggcc agggcaccaa ggtggagatc aagaggaacg acgctcagcc agccgtgtac      360

ctcttccagc cttcgccgga ccagcttcat acggggtcag cgtcggtggt gtgcctgttg      420

aactcgtttt accccaagga cattaacgtg aagtggaagg tagacggggt aattcaagac      480

actggcattc aagagtccgt cacggaacaa gactcaaaag actcaacgta ttcactgtcg      540

tcaaccttga cgatgtcaag caccgagtat cttagccatg agctgtattc gtgcgagatc      600

acccacaagt ccctcccctc cactcttatc aaatcctttc agcggtcgga atgtcagcgg      660

gtcgat                                                                 666


<210>  34
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  34

Asp Ile Val Leu Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Phe Ser Tyr Leu His Trp Tyr Arg Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Phe Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
            180                 185                 190         


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
        195                 200                 205             


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220         


<210>  35
<211>  867
<212>  DNA
<213>  Canis familiaris

<400>  35
atggggagcc ggcgggggcc ctggccgctc gtctgggccg tgctgcagct gggctggtgg       60

ccaggatggc tcctagactc ccctgacagg ccctggagcc cgctcacctt ctccccggcg      120

cagctcacgg tgcaggaggg agagaacgcc acgttcacct gcagcctggc cgacatcccc      180

gacagcttcg tgctcaactg gtaccgcctg agcccccgca accagacgga caagctggcc      240

gccttccagg aggaccgcat cgagccgggc cgggacaggc gcttccgcgt catgcggctg      300

cccaacgggc gggacttcca catgagcatc gtcgctgcgc gcctcaacga cagcggcatc      360

tacctgtgcg gggccatcta cctgcccccc aacacacaga tcaacgagag tccccgcgca      420

gagctctccg tgacggagag aaccctggag ccccccacac agagccccag ccccccaccc      480

agactcagcg gccagttgca ggggctggtc atcggcgtca cgagcgtgct ggtgggtgtc      540

ctgctactgc tgctgctgac ctgggtcctg gccgctgtct tccccagggc cacccgaggt      600

gcctgtgtgt gcgggagcga ggacgagcct ctgaaggagg gccccgatgc agcgcccgtc      660

ttcaccctgg actacgggga gctggacttc cagtggcgag agaagacgcc ggagcccccg      720

gcgccctgtg ccccggagca gaccgagtat gccaccatcg tcttcccggg caggccggcg      780

tccccgggcc gcagggcctc ggccagcagc ctgcagggag cccagcctcc gagccccgag      840

gacggacccg gcctgtggcc cctctga                                          867


<210>  36
<211>  288
<212>  PRT
<213>  Canis familiaris

<400>  36

Met Gly Ser Arg Arg Gly Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Trp Pro Gly Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu Gly Glu 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Met Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile Val Ala 
            100                 105                 110         


Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Ser Val 
    130                 135                 140                 


Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Arg Leu Ser Gly Gln Leu Gln Gly Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Val Gly Val Leu Leu Leu Leu Leu Leu Thr Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Pro Arg Ala Thr Arg Gly Ala Cys Val Cys Gly Ser Glu Asp 
        195                 200                 205             


Glu Pro Leu Lys Glu Gly Pro Asp Ala Ala Pro Val Phe Thr Leu Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
225                 230                 235                 240 


Ala Pro Cys Ala Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Pro Ala Ser Pro Gly Arg Arg Ala Ser Ala Ser Ser Leu Gln 
            260                 265                 270         


Gly Ala Gln Pro Pro Ser Pro Glu Asp Gly Pro Gly Leu Trp Pro Leu 
        275                 280                 285             


<210>  37
<211>  870
<212>  DNA
<213>  Canis familiaris

<400>  37
atgagaatgt ttagtgtctt tacattcatg gcctactgcc atttgctaaa agcatttacg       60

atcacagttt ctaaggacct gtatgtggta gagtatggtg gcaatgtgac aatggaatgc      120

aaattcccgg tggaaaaaca gttaaacttg tttgcactaa tcgtctactg ggaaatggag      180

gataaaaaaa ttatacaatt tgtgaatgga aaggaagacc tgaaagttca gcacagcagc      240

tacagccaga gggctcagct attgaaggac cagctcttct tggggaaggc tgcgcttcag      300

atcacagatg tgagattgca ggatgcaggg gtttactgct gcttgatcgg ctatggcggt      360

gctgactaca agcggattac tttgaaagtt catgccccgt accgcaacat cagccaaaga      420

atttctgtgg atcctgtcac ctctgaacat gaactaatgt gtcaggctga gggttaccct      480

gaggctgaag tcatctggac aagcagtgac caccgagtcc tgagtggcaa aaccaccatc      540

actaattcca atagggaaga gaagcttttc aatgtgacca gcacgctgaa catcaatgca      600

acagctaatg agattttcta ctgcactttt caaagatcag gtcctgagga aaacaatact      660

gccgagttgg tcatcccaga acgactgccc gttccagcaa gtgagaggac tcatttcatg      720

attctgggac ctttcctgtt gcttcttggt gtagtcctgg cagtcacttt ctgtctaaaa      780

aaacatggga gaatgatgga tgtggaaaaa tgttgcaccc gagataggaa ctcaaagaaa      840

cgaaatgata tacaatttga agagacataa                                       870


<210>  38
<211>  289
<212>  PRT
<213>  Canis familiaris

<400>  38

Met Arg Met Phe Ser Val Phe Thr Phe Met Ala Tyr Cys His Leu Leu 
1               5                   10                  15      


Lys Ala Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Gly Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asn Leu Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile 
    50                  55                  60                  


Ile Gln Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Ser Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Val Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly 
                165                 170                 175     


Lys Thr Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val 
            180                 185                 190         


Thr Ser Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys 
        195                 200                 205             


Thr Phe Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val 
    210                 215                 220                 


Ile Pro Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Phe Met 
225                 230                 235                 240 


Ile Leu Gly Pro Phe Leu Leu Leu Leu Gly Val Val Leu Ala Val Thr 
                245                 250                 255     


Phe Cys Leu Lys Lys His Gly Arg Met Met Asp Val Glu Lys Cys Cys 
            260                 265                 270         


Thr Arg Asp Arg Asn Ser Lys Lys Arg Asn Asp Ile Gln Phe Glu Glu 
        275                 280                 285             


Thr 
    


<210>  39
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  39
atggccgtgc tggggctgct cttctgcctg gtgacattcc caagctgtgt gctaagcgag       60

gtgcagctgg tgcagtccgg cggcgatctg gtgaagcctg gaggcagcgt gagactgagc      120

tgcgtggcca gcggctacac cttcaccagc tactacctgt actgggtgag gcaggctcct      180

ggcaaaggac tgcagtggat cggcggcgtg aatcctagca acggcggcac caacttcagc      240

gagaagttca agagcagggc caccctgagc gtggacaagg ccaagaacac cgcctacatg      300

cagctgaact ccctgagggc cgaggacacc gccgtgtact actgcaccag gagggacagc      360

aactacgacg gcggcttcga ctactgggga cagggaaccc tgctgaccgt gtccagcgct      420

tccacaacgg ctccgtcggt gtttcccctg gcacctagct gcgggtcgac ctcgggtagc      480

acagtggcgc tggcgtgttt ggtgtcggga tactttcccg agccggtaac ggtgtcatgg      540

aactcagggt cacttacatc aggagtccat acttttccgt ccgtgctgca gtcaagcggc      600

ttgcattcac tgtcctcgat ggtgacggtg ccttcgtcga ggtggcccag cgaaacgttc      660

acttgtaacg tagtacaccc ggcctccaac acgaaagtcg ataaaccggt attcaatgag      720

tgcagatgta cagacacccc tccctgtccg gtacccgaac cccttggagg gccgagcgtc      780

ctcatcttcc ctcccaagcc aaaagacatc ttgcgcatta cgaggacacc agaagtcacg      840

tgcgtagtgc ttgatctcgg tagagaagat cccgaggtcc agatctcgtg gtttgtggat      900

ggaaaggagg tccacaccgc aaagactcag tcgcgcgagc agcagttcaa tggcacgtat      960

cgggtcgtga gcgtgcttcc tatcgagcat caggactggc tcaccgggaa ggagttcaaa     1020

tgccgggtca atcatatcga cctcccgtca ccaatcgagc ggaccatctc gaaggctaga     1080

ggaagggcgc acaaaccttc ggtctatgtg cttcccccat cgcccaaaga gctttcctcg     1140

tcggatacgg tgtccattac atgcttgatt aaggacttct atcctcctga tattgatgtg     1200

gaatggcaat caaacggaca gcaggagccg gaacgcaagc accgaatgac cccaccgcaa     1260

ttggacgaag atggtagcta ctttctctac tcaaagctct cagtcgacaa atcccgatgg     1320

cagcagggag atcccttcac ttgcgccgtg atgcacgaga cactccaaaa tcattacacg     1380

gacctttcgt tgagccactc gcccggaaag                                      1410


<210>  40
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  40

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Ile Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu 
225                 230                 235                 240 


Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  41
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  41
atggccgtgc tggggctgct cttctgcctg gtgacattcc caagctgtgt gctaagcgag       60

gtgcagctgg tgcagtccgg cggcgatctg gtgaagcctg gaggcagcgt gagactgagc      120

tgcgtggcca gcggctacac cttcaccagc tactacctgt actgggtgag gcaggctcct      180

ggcaaaggac tgcagtggat cggcggcgtg aatcctagca acggcggcac caacttcagc      240

gagaagttca agagcagggc caccctgagc gtggacaagg ccaagaacac cgcctacatg      300

cagctgaact ccctgagggc cgaggacacc gccgtgtact actgcaccag gagggacagc      360

aactacgacg gcggcttcga ctactgggga cagggaaccc tgctgaccgt gtccagcgct      420

tccacaaccg cgccatcagt ctttccgttg gccccatcat gcgggtcgac gagcggatcg      480

actgtggccc tggcgtgctt ggtgtcggga tactttcccg aacccgtcac ggtcagctgg      540

aactccggat cgcttacgag cggtgtgcat acgttcccct cggtcttgca atcatcaggg      600

ctctactcgc tgtcgagcat ggtaacggtg ccctcatcga ggtggccctc cgaaacgttc      660

acatgtaacg tagcacatcc agcctccaaa accaaggtgg ataaacccgt gccgaaaaga      720

gagaatgggc gggtgcctcg accccctgat tgccccaagt gtccggctcc ggaaatgctc      780

ggtggaccct cagtgtttat cttccctccg aagcccaagg acactctgct gatcgcgcgc      840

actccagaag taacatgtgt agtggtggac cttgatcccg aggaccccga agtccagatc      900

tcctggtttg tagatgggaa acagatgcag accgcaaaaa ctcaacccag agaggagcag      960

ttcaacggaa cataccgagt ggtatccgtc cttccgattg gccaccagga ctggttgaaa     1020

gggaagcagt ttacgtgtaa agtcaacaat aaggcgttgc ctagccctat tgagcggacg     1080

atttcgaaag ctaggggaca ggcccaccag ccatcggtct atgtccttcc gccttcccgc     1140

gaggagctct cgaagaatac agtgagcctt acatgcctca ttaaggattt cttcccgcct     1200

gatatcgacg tagagtggca atcaaacggt caacaggagc cggaatccaa gtatagaacc     1260

actccgcccc agcttgacga ggacggatca tactttttgt attcaaaact gtcggtggat     1320

aagagccggt ggcagagagg tgacaccttc atctgtgcgg tgatgcacga agcactccat     1380

aatcactaca cccaagagag cctctcgcat tcccccggaa agtga                     1425


<210>  42
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  42

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Ile Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
225                 230                 235                 240 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
                245                 250                 255     


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
                325                 330                 335     


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
            340                 345                 350         


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
        355                 360                 365             


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
    370                 375                 380                 


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
385                 390                 395                 400 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
                405                 410                 415     


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
        435                 440                 445             


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 


<210>  43
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  43
atggccgtgc tggggctgct cttctgcctg gtgacattcc caagctgtgt gctaagcgag       60

gtgcagctgg tgcagtccgg cggcgatctg gtgaagcctg gaggcagcgt gagactgagc      120

tgcgtggcca gcggctacac cttcaccagc tactacctgt actgggtgag gcaggctcct      180

ggcaaaggac tgcagtggat cggcggcgtg aatcctagca acggcggcac caacttcagc      240

gagaagttca agagcagggc caccctgagc gtggacaagg ccaagaacac cgcctacatg      300

cagctgaact ccctgagggc cgaggacacc gccgtgtact actgcaccag gagggacagc      360

aactacgacg gcggcttcga ctactgggga cagggaaccc tgctgaccgt gtccagcgct      420

tcaaccacag cgccgagcgt gttccctctg gcgccgtcgt gcggttccac ctcgggatca      480

acagtggccc tcgcctgtct cgtgagcgga tactttccgg agcctgtcac ggtgtcgtgg      540

aatagcggat cactcacgtc gggcgtgcat acttttccat ccgtcttgca atcgagcgga      600

ttgtactcac tctcctcaac cgtcactgtc ccctcgtcgc gctggccctc ggagactttt      660

acgtgcaatg tagtccatcc ggcgagcaac acgaaggtcg acaagcccgt acccaaggaa      720

tcaacatgca agtgcatctc gccctgtccc gtccccgaat cccttggtgg cccctcagtg      780

tttatcttcc ctccgaagcc taaagacatc ttgagaatca caagaacacc ggaaatcacg      840

tgtgtggtcc ttgacttggg acgcgaggac cctgaggtac aaatctcgtg gtttgtggac      900

gggaaagagg tgcacacagc aaagacacaa ccacgcgagc agcagtttaa ctcaacgtac      960

agggtagtat ccgtacttcc cattgaacac caggattggc tcaccggtaa agaattcaaa     1020

tgccgagtga atcacatcgg gcttcctagc ccaattgagc ggacgatttc caaagctagg     1080

ggtcaggccc accagccgag cgtatacgtg ttgccgccct ccccgaagga gctgtcatcg     1140

tcagatacgg taacgttgac gtgtctgatc aaagatttct ttcctcccga aattgatgtg     1200

gaatggcaaa gcaatgggca gcccgagccc gagtcaaagt accatactac tgcaccacag     1260

ctggacgaag atggatcgta tttcctctac tcgaaactgt ccgtggataa gtcccggtgg     1320

cagcaagggg acaccttcac ttgcgcggtc atgcacgagg cacttcagaa ccactatacg     1380

gacttgagcc tctcgcattc gccagggaag                                      1410


<210>  44
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  44

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Val Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Ile Gly Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Leu Ser Val Asp Lys Ala Lys Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu 
225                 230                 235                 240 


Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr 
                405                 410                 415     


Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  45
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  45
atggatatga gagtacctgc acaacttctg ggattgctgc ttctttggct gagaggggcc       60

cgctgcgata tcgtcctgac ccagacccct ctgagcctgt ccgtgagccc tggagaaccc      120

gccagcatca gctgcagggc ctccaagagc gtgagcacca gcggcttcag ctacctgcac      180

tggtacaggc agaagcccgg acagagccct cagctgctga tcttcctggc cagcaacctg      240

gagagcggcg tgcctgacag gtttagcgga agcggcagcg gcaccgactt cacactgagg      300

atctccaggg tggaagccga cgacgccgga gtgtactact gccagcacag ctgggaactg      360

cccctgacct tcggccaggg caccaaggtg gagatcaaga ggaacgacgc tcagccagcc      420

gtgtacctct tccagccttc gccggaccag cttcatacgg ggtcagcgtc ggtggtgtgc      480

ctgttgaact cgttttaccc caaggacatt aacgtgaagt ggaaggtaga cggggtaatt      540

caagacactg gcattcaaga gtccgtcacg gaacaagact caaaagactc aacgtattca      600

ctgtcgtcaa ccttgacgat gtcaagcacc gagtatctta gccatgagct gtattcgtgc      660

gagatcaccc acaagtccct cccctccact cttatcaaat cctttcagcg gtcggaatgt      720

cagcgggtcg at                                                          732


<210>  46
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  46

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Lys Ser Val Ser Thr Ser Gly Phe Ser Tyr Leu His Trp Tyr Arg Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Asp Asp Ala Gly Val Tyr 
            100                 105                 110         


Tyr Cys Gln His Ser Trp Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe 
    130                 135                 140                 


Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val 
                165                 170                 175     


Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser 
        195                 200                 205             


Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His 
    210                 215                 220                 


Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys 
225                 230                 235                 240 


Gln Arg Val Asp 
                


<210>  47
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  47
atggatatga gagtacctgc acaacttctg ggattgctgc ttctttggct gagaggggcc       60

cgctgcgata tcgtcctgac ccagacccct cctagcctgt ccgtgagccc tggagaaccc      120

gccagcatca gctgcagggc ctccaagagc gtgagcacca gcggcttcag ctacctgcac      180

tggtacaggc agaagcccgg acagcctcct cagctgctga tcttcctggc cagcaacctg      240

gagagcggcg tgcctgacag gtttagcgga agcggcagcg gcaccgactt cacactgagg      300

atctccaggg tggaagccga cgacgccgga gtgtactact gccagcacag ctgggaactg      360

cccctgacct tcggccaggg caccaaggtg gagatcaaga ggaacgacgc tcagccagcc      420

gtgtacctct tccagccttc gccggaccag cttcatacgg ggtcagcgtc ggtggtgtgc      480

ctgttgaact cgttttaccc caaggacatt aacgtgaagt ggaaggtaga cggggtaatt      540

caagacactg gcattcaaga gtccgtcacg gaacaagact caaaagactc aacgtattca      600

ctgtcgtcaa ccttgacgat gtcaagcacc gagtatctta gccatgagct gtattcgtgc      660

gagatcaccc acaagtccct cccctccact cttatcaaat cctttcagcg gtcggaatgt      720

cagcgggtcg at                                                          732


<210>  48
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  48

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Thr Pro Pro Ser 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Lys Ser Val Ser Thr Ser Gly Phe Ser Tyr Leu His Trp Tyr Arg Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Phe Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Asp Asp Ala Gly Val Tyr 
            100                 105                 110         


Tyr Cys Gln His Ser Trp Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe 
    130                 135                 140                 


Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val 
                165                 170                 175     


Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser 
        195                 200                 205             


Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His 
    210                 215                 220                 


Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys 
225                 230                 235                 240 


Gln Arg Val Asp 
                


<210>  49
<211>  336
<212>  PRT
<213>  Canis familiaris

<400>  49

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  50
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine sequence

<400>  50

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
145                 150                 155                 160 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
            180                 185                 190         


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
        195                 200                 205             


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
    210                 215                 220                 


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
225                 230                 235                 240 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
    290                 295                 300                 


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  51
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine sequence

<400>  51

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
145                 150                 155                 160 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
            180                 185                 190         


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
        195                 200                 205             


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
    210                 215                 220                 


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
225                 230                 235                 240 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
    290                 295                 300                 


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  52
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine sequence

<400>  52

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  53
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  53

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Leu Asp Ser Pro Asp Arg 
            20                  25                  30          


Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu 
        35                  40                  45              


Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser 
    50                  55                  60                  


Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys 
65                  70                  75                  80  


Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg 
                85                  90                  95      


Phe Arg Val Met Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile 
            100                 105                 110         


Val Ala Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile 
        115                 120                 125             


Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu 
    130                 135                 140                 


Ser Val Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro 
145                 150                 155                 160 


Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly Leu Val Gly Thr Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys 
    


