                         SEQUENCE LISTING

<110>  Friedrich-Alexander Universitt Erlangen-Nrnberg
 
<120>  Influenza-specific T-cell receptor and its uses in the detection,
        prevention and/or treatment of influenza

<130>  U30517WO

<150>  EP 13 198 519.4
<151>  2013-12-19

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Asn Thr Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu 
1               5                   10                  15      


Thr Val Lys Pro 
            20  


<210>  2
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Leu Asn Thr Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  3
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Ser Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
1               5                   10                  15      


Val 
    


<210>  4
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Thr Ser Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  5
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  5
ttaacaccaa tgcaggcaaa tcaacctttg gggatgggac tacgctcact gtgaagccaa       60


<210>  6
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcctctg cacccatctc gatgcttgcg atgctcttca cattgagtgg gctgagagct       60

cagtcagtgg ctcagccgga agatcaggtc aacgttgctg aagggaatcc tctgactgtg      120

aaatgcacct attcagtctc tggaaaccct tatctttttt ggtatgttca ataccccaac      180

cgaggcctcc agttccttct gaaatacatc acaggggata acctggttaa aggcagctat      240

ggctttgaag ctgaatttaa caagagccaa acctccttcc acctgaagaa accatctgcc      300

cttgtgagcg actccgcttt gtacttctgt gctgtgagag atcttaacac caatgcaggc      360

aaatcaacct ttggggatgg gactacgctc actgtgaagc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagc                      825


<210>  7
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  7
atcgggcact gaagctttct ttggacaagg caccagactc acagttgta                   49


<210>  8
<211>  924
<212>  DNA
<213>  Homo sapiens

<400>  8
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat       60

ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg      120

agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa      180

gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct      240

gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc      300

caaaagaacc cgacagcttt ctatctctgt gccagtagtt ctacatcggg cactgaagct      360

ttctttggac aaggcaccag actcacagtt gtagaggacc tgaacaaggt gttcccaccc      420

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      480

gtgtgcctgg ccacaggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggg      540

aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc      600

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac      660

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg      720

acccaggata gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca      780

gactgtggct ttacctcggt gtcctaccag caaggggtcc tgtctgccac catcctctat      840

gagatcctgc tagggaaggc caccctgtat gctgtgctgg tcagcgccct tgtgttgatg      900

gccatggtca agagaaagga tttc                                             924


<210>  9
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  9

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  10

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  11
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  64T-Primer with V = A, G, C; N = A, C, G, T


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  n is a, c, g, or t

<400>  11
cgataaaagc tccggggata acagattttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt ttttttttvn                                        90


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Block primer

<400>  12
aagcagtggt aacaacgcag agtacgcgg                                         29


<210>  13
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7-capswitch primer

<400>  13
ttatacgact cactataggg aggaagcagt ggtaacaacg cagagt                      46


<210>  14
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SMARTarg primer

<400>  14
aagcagtggt aacaacgcag agtacg                                            26


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C alpha 3UTR primer

<400>  15
ctgtcttaca atcttgcaga tc                                                22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C beta 1 3`UTR primer

<400>  16
ccacttccag ggctgccttc                                                   20


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C beta 2 3UTR primer

<400>  17
tgacctggga tggttttgga gcta                                              24


<210>  18
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AV16s1_TRAV3 Primer

<400>  18
gactctagat ggcctctgca cccatc                                            26


<210>  19
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Calpha-XhoI primer

<400>  19
ctctcgagca tcttgcagat ctcagctgga ccaca                                  35


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BV17s1_TRBV19 primer

<400>  20
gactctagat gagcaaccag gtgctct                                           27


<210>  21
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCbeta1-XhoI/EcoRI  primer

<400>  21
ggaattcctc gagggatccc tgccttcaga aatcctttct c                           41


