                         SEQUENCE LISTING

<110>  KING'S COLLEGE LONDON and GALDERMA RESEARCH & DEVELOPMENT
 
<120>  OVOL1 as a new marker for moderate to severe acne

<130>  B1737PC00

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  3039
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (341)..(1144)

<400>  1
aataaagcgt gaacccgtcc gtccggctcg cactttaaga cttcccgagc ggcggcgggg       60

acgccagtcg agccgggaga cgcttacctg ccgcttcccc gcgccgcccg gtgcacctgg      120

ccgcaaggga cctcgttctc agggaagacg gcgacattcc gcggaggtgg aaccgccgcg      180

cgccgtccgg gctcggacct tccccggaac gtgggggcgc cttagcgact ccttccctgt      240

tgtgcccccg ttcccggcgt tcagcccggc cccgcaaagg tgggacggct cccggcttca      300

gttacggaag cggcccgtgt ccagcgacga gggttcgaaa atg ccc cgc gcg ttc        355
                                            Met Pro Arg Ala Phe           
                                            1               5             

ctg gtg aag aag ccg tgc gtc tcc acg tgc aag agg aac tgg agc gag        403
Leu Val Lys Lys Pro Cys Val Ser Thr Cys Lys Arg Asn Trp Ser Glu           
                10                  15                  20                

ctc ccc gac gag gag cgc ggc gag atc tac gtg cca gtc agc ctg ggc        451
Leu Pro Asp Glu Glu Arg Gly Glu Ile Tyr Val Pro Val Ser Leu Gly           
            25                  30                  35                    

ttc tgc cca cca cag ccc tac cgg gag ccg gaa ccc tct gtg gcc gaa        499
Phe Cys Pro Pro Gln Pro Tyr Arg Glu Pro Glu Pro Ser Val Ala Glu           
        40                  45                  50                        

ccc cct tcc tgc ccg ctg gct ttg aac atg agc ctt cga gac tct agc        547
Pro Pro Ser Cys Pro Leu Ala Leu Asn Met Ser Leu Arg Asp Ser Ser           
    55                  60                  65                            

tac agc atg gcc ccc ggg ccc tgt gtg gtg gcc cag ctg ccc tct gaa        595
Tyr Ser Met Ala Pro Gly Pro Cys Val Val Ala Gln Leu Pro Ser Glu           
70                  75                  80                  85            

gac atg ggc cac ttg aca gac ccc cag agc aga gac cat ggc ttc ctg        643
Asp Met Gly His Leu Thr Asp Pro Gln Ser Arg Asp His Gly Phe Leu           
                90                  95                  100               

cgc acc aag atg aag gtg acc ctt ggg gac agt ccc agt gga gac ctg        691
Arg Thr Lys Met Lys Val Thr Leu Gly Asp Ser Pro Ser Gly Asp Leu           
            105                 110                 115                   

ttc acc tgc cgt gtc tgc cag aag gcc ttc acc tac cag cgc atg ctg        739
Phe Thr Cys Arg Val Cys Gln Lys Ala Phe Thr Tyr Gln Arg Met Leu           
        120                 125                 130                       

aac cgc cac atg aag tgt cac aac gac gtc aag agg cac ctc tgc acg        787
Asn Arg His Met Lys Cys His Asn Asp Val Lys Arg His Leu Cys Thr           
    135                 140                 145                           

tac tgc ggg aag ggc ttc aat gac acc ttc gac ctc aag aga cac gtc        835
Tyr Cys Gly Lys Gly Phe Asn Asp Thr Phe Asp Leu Lys Arg His Val           
150                 155                 160                 165           

cga act cac act ggc gtg cgg ccc tac aag tgc agc ctg tgt gac aag        883
Arg Thr His Thr Gly Val Arg Pro Tyr Lys Cys Ser Leu Cys Asp Lys           
                170                 175                 180               

gcc ttc acg cag cgc tgc tct ctg gag tct cac ctc aag aag atc cat        931
Ala Phe Thr Gln Arg Cys Ser Leu Glu Ser His Leu Lys Lys Ile His           
            185                 190                 195                   

ggt gtg cag cag aag tac gcg tac aag gag cgg cgg gcc aag ctg tac        979
Gly Val Gln Gln Lys Tyr Ala Tyr Lys Glu Arg Arg Ala Lys Leu Tyr           
        200                 205                 210                       

gtg tgt gag gag tgc ggc tgc aca tct gag agc cag gag ggc cac gtc       1027
Val Cys Glu Glu Cys Gly Cys Thr Ser Glu Ser Gln Glu Gly His Val           
    215                 220                 225                           

ctg cac ctg aag gag cac cac cct gac agc ccg ctg ctg cgc aag acc       1075
Leu His Leu Lys Glu His His Pro Asp Ser Pro Leu Leu Arg Lys Thr           
230                 235                 240                 245           

tcc aag aag gtg gcc gtg gca cta cag aac act gtc act tcc ctg ctg       1123
Ser Lys Lys Val Ala Val Ala Leu Gln Asn Thr Val Thr Ser Leu Leu           
                250                 255                 260               

cag ggc agc ccc cac ctg tga gtggctcgag ccctgggggt gctcctggaa          1174
Gln Gly Ser Pro His Leu                                                   
            265                                                           

gccccaagag catccaggat tgcctcccag ctgcctggcc agcccaccct cctgcaacct     1234

ctcacccgaa caccagtgat caggactgga gcccccgtgc cttggtctcc cccctgggca     1294

cacgtgctca ctcaggccca gcaatgacct ctgctcattt ttgcattttt gacttatggg     1354

ccgaggctgt tctgagcctg ggaagatgta cctatgtcaa gagaagggat gaggccaagg     1414

ctgccttcaa ttagaagcag ccgcccacag agacaggcac tgtgtgcctg gcagcaggac     1474

ttcctaccca gaggaggttc gagctaggat cccactgccc ccgcctctca gcacagggca     1534

ggggctgcag gtccccagtg gacatcagag tcaaaagcac tggcaaaggg tacccctgca     1594

aacaactgtg gtgggggctg gcagcagacc ccccacctgg cagggcttct aatgctcagg     1654

gttctggagg gctctgtcct tccggcaagg agaggcacac atgtgtgccc agccgtgtgt     1714

gtgcgtgtgc ttgtgtgtgt gcactgctgt gtgtgtgtgc acgcacagga agcctttcca     1774

catatcacct catttctaag aaataaacta caaggtgcca agaaggtttt atttcctttt     1834

attttttaaa gatgacaaat gtacagatgt taatatattt ttggtgccaa tggcgatgtt     1894

tttaagagtg ggatggagct ggcttttctc cattcccgtg cgcttctatt tatcctggac     1954

atttcaaacc tcctctgtgc cttggctctg ggcgggggct gccccaaccc acccccgttc     2014

tttgtacgtg ctgagacagc cactagaaga tcttcctcca gcggcgccct ggacggctgc     2074

tcctgcgaac agcccatggc atcttctgct cttccctccc ggctctgccc tgcacatcct     2134

gttgagccaa gccccagtga cccggagagc tggcctgatg ctgagagtgt gtcctcctgg     2194

ggctttaggg ggcaggaagg tgggacgaat gacgatgccc atccactacc tgaagcacta     2254

ggacactctt gcagggccag gctggaagac cggccctttt cttggttgag tcaaaagcct     2314

tagcacagtg gcaaaaaatg ggacagaatg atgaccagca cctcagaaac ttccagaggg     2374

aggagaggat ttgatggcta ccaaattgta tctgttgcct tttttctgac tttttcacct     2434

gaccaggctg gggtttggag tggctgtggg gagacccgtc ctggctggct ggctggctcc     2494

cttgctccct tgctgcagct gggaaagggg ttctgggtgt aaagaggtgt gcgtcttgtg     2554

ggccaaaggg aaaaacaggc aggggtcaga gccagcctgc cagaggcaaa tgcaaaagag     2614

gtccccagaa cacagccagc tgggcagccc cttaaagcca aaccccacct gaagcagaac     2674

cactttggcc tcccctgccc aaaatgggta gtgtctacac gtccccgggc tcaggctcag     2734

gcccagccct gggctgacct gagaggaagg ctccttcctg gactgccctc tgaaatgtgt     2794

atagattgat tctaaaatct cttgtttcac ttgactttag agtgtctggg acgctgctgt     2854

attctgaaag tcacatagca cacagtaatg ttatctggaa gctctgtttt tgtttacatt     2914

tctgtatccc tgggttgact gccaatccga ggccgtcatg aagctctgtg ttgtctgttt     2974

tattttataa ccttcctctc aactattaaa attagagatc taatgtttaa aaaaaaaaaa     3034

aaaaa                                                                 3039


<210>  2
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Ala Phe Leu Val Lys Lys Pro Cys Val Ser Thr Cys Lys 
1               5                   10                  15      


Arg Asn Trp Ser Glu Leu Pro Asp Glu Glu Arg Gly Glu Ile Tyr Val 
            20                  25                  30          


Pro Val Ser Leu Gly Phe Cys Pro Pro Gln Pro Tyr Arg Glu Pro Glu 
        35                  40                  45              


Pro Ser Val Ala Glu Pro Pro Ser Cys Pro Leu Ala Leu Asn Met Ser 
    50                  55                  60                  


Leu Arg Asp Ser Ser Tyr Ser Met Ala Pro Gly Pro Cys Val Val Ala 
65                  70                  75                  80  


Gln Leu Pro Ser Glu Asp Met Gly His Leu Thr Asp Pro Gln Ser Arg 
                85                  90                  95      


Asp His Gly Phe Leu Arg Thr Lys Met Lys Val Thr Leu Gly Asp Ser 
            100                 105                 110         


Pro Ser Gly Asp Leu Phe Thr Cys Arg Val Cys Gln Lys Ala Phe Thr 
        115                 120                 125             


Tyr Gln Arg Met Leu Asn Arg His Met Lys Cys His Asn Asp Val Lys 
    130                 135                 140                 


Arg His Leu Cys Thr Tyr Cys Gly Lys Gly Phe Asn Asp Thr Phe Asp 
145                 150                 155                 160 


Leu Lys Arg His Val Arg Thr His Thr Gly Val Arg Pro Tyr Lys Cys 
                165                 170                 175     


Ser Leu Cys Asp Lys Ala Phe Thr Gln Arg Cys Ser Leu Glu Ser His 
            180                 185                 190         


Leu Lys Lys Ile His Gly Val Gln Gln Lys Tyr Ala Tyr Lys Glu Arg 
        195                 200                 205             


Arg Ala Lys Leu Tyr Val Cys Glu Glu Cys Gly Cys Thr Ser Glu Ser 
    210                 215                 220                 


Gln Glu Gly His Val Leu His Leu Lys Glu His His Pro Asp Ser Pro 
225                 230                 235                 240 


Leu Leu Arg Lys Thr Ser Lys Lys Val Ala Val Ala Leu Gln Asn Thr 
                245                 250                 255     


Val Thr Ser Leu Leu Gln Gly Ser Pro His Leu 
            260                 265         


