                         SEQUENCE LISTING

<110>  Westfaelische Wilhelms-Universitaet Muenster
 
<120>  MEANS AND METHODS FOR TREATING A PRURITUS-LIKE SKIN-DISEASE

<130>  UKM14831PCT

<150>  US61/916,993
<151>  2013-12-17

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2236
<212>  DNA
<213>  Homo sapiens

<400>  1
tgcagaagcc tgaagaccaa ggagtggaaa gttctccggc agccctgaga tctcaagagt       60

gacatttgtg agaccagcta atttgattaa aattctcttg gaatcagctt tgctagtatc      120

atacctgtgc cagatttcat catgggaaac agctgttaca acatagtagc cactctgttg      180

ctggtcctca actttgagag gacaagatca ttgcaggatc cttgtagtaa ctgcccagct      240

ggtacattct gtgataataa caggaatcag atttgcagtc cctgtcctcc aaatagtttc      300

tccagcgcag gtggacaaag gacctgtgac atatgcaggc agtgtaaagg tgttttcagg      360

accaggaagg agtgttcctc caccagcaat gcagagtgtg actgcactcc agggtttcac      420

tgcctggggg caggatgcag catgtgtgaa caggattgta aacaaggtca agaactgaca      480

aaaaaaggtt gtaaagactg ttgctttggg acatttaacg atcagaaacg tggcatctgt      540

cgaccctgga caaactgttc tttggatgga aagtctgtgc ttgtgaatgg gacgaaggag      600

agggacgtgg tctgtggacc atctccagcc gacctctctc cgggagcatc ctctgtgacc      660

ccgcctgccc ctgcgagaga gccaggacac tctccgcaga tcatctcctt ctttcttgcg      720

ctgacgtcga ctgcgttgct cttcctgctg ttcttcctca cgctccgttt ctctgttgtt      780

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa      840

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      900

gaactgtgaa atggaagtca atagggctgt tgggactttc ttgaaaagaa gcaaggaaat      960

atgagtcatc cgctatcaca gctttcaaaa gcaagaacac catcctacat aatacccagg     1020

attcccccaa cacacgttct tttctaaatg ccaatgagtt ggcctttaaa aatgcaccac     1080

tttttttttt tttttgacag ggtctcactc tgtcacccag gctggagtgc agtggcacca     1140

ccatggctct ctgcagcctt gacctctggg agctcaagtg atcctcctgc ctcagtctcc     1200

tgagtagctg gaactacaag gaagggccac cacacctgac taactttttt gttttttgtt     1260

tggtaaagat ggcatttcac catgttgtac aggctggtct caaactccta ggttcacttt     1320

ggcctcccaa agtgctggga ttacagacat gaactgccag gcccggccaa aataatgcac     1380

cacttttaac agaacagaca gatgaggaca gagctggtga taaaaaaaaa aaaaaaaaag     1440

cattttctag ataccactta acaggtttga gctagttttt ttgaaatcca aagaaaatta     1500

tagtttaaat tcaattacat agtccagtgg tccaactata attataatca aaatcaatgc     1560

aggtttgttt tttggtgcta atatgacata tgacaataag ccacgaggtg cagtaagtac     1620

ccgactaaag tttccgtggg ttctgtcatg taacacgaca tgctccaccg tcagggggga     1680

gtatgagcag agtgcctgag tttagggtca aggacaaaaa acctcaggcc tggaggaagt     1740

tttggaaaga gttcaagtgt ctgtatatcc tatggtcttc tccatcctca caccttctgc     1800

ctttgtcctg ctccctttta agccaggtta cattctaaaa attcttaact tttaacataa     1860

tattttatac caaagccaat aaatgaactg catatgatag gtatgaagta cagtgagaaa     1920

attaacacct gtgagctcat tgtcctacca cagcactaga gtgggggccg ccaaactccc     1980

atggccaaac ctggtgcacc atttgccttt gtttgtctgt tggtttgctt gagacagtct     2040

tgctctgttg cccaggctgg aatggagtgg ctattcacag gcacaatcat agcacacttt     2100

agccttaaac tcctgggctc aagtgatcca cccgcctcag tctcccaagt agctgggatt     2160

acaggtgcaa acctggcatg cctgccattg tttggcttat gatctaagga tagcttttta     2220

aattttattc atttta                                                     2236


<210>  2
<211>  2134
<212>  DNA
<213>  Mus musculus

<400>  2
ttcctgaaat tcaggtgctg caggcagccc tcagcacaga gagctgacag ggaccctggg       60

tcaggggttc tgagttccag ctgccactat tcttcttcac ctttggtgtc ctgtgcatgt      120

gacatttcgc catgggaaac aactgttaca acgtggtggt cattgtgctg ctgctagtgg      180

gctgtgagaa ggtgggagcc gtgcagaact cctgtgataa ctgtcagcct ggtactttct      240

gcagaaaata caatccagtc tgcaagagct gccctccaag taccttctcc agcataggtg      300

gacagccgaa ctgtaacatc tgcagagtgt gtgcaggcta tttcaggttc aagaagtttt      360

gctcctctac ccacaacgcg gagtgtgagt gcattgaagg attccattgc ttggggccac      420

agtgcaccag atgtgaaaag gactgcaggc ctggccagga gctaacgaag cagggttgca      480

aaacctgtag cttgggaaca tttaatgacc agaacggtac tggcgtctgt cgaccctgga      540

cgaactgctc tctagacgga aggtctgtgc ttaagaccgg gaccacggag aaggacgtgg      600

tgtgtggacc ccctgtggtg agcttctctc ccagtaccac catttctgtg actccagagg      660

gaggaccagg agggcactcc ttgcaggtcc ttaccttgtt cctggcgctg acatcggctt      720

tgctgctggc cctgatcttc attactctcc tgttctctgt gctcaaatgg atcaggaaaa      780

aattccccca catattcaag caaccattta agaagaccac tggagcagct caagaggaag      840

atgcttgtag ctgccgatgt ccacaggaag aagaaggagg aggaggaggc tatgagctgt      900

gatgtactat cctaggagat gtgtgggccg aaaccgagaa gcactaggac cccaccatcc      960

tgtggaacag cacaagcaac cccaccaccc tgttcttaca catcatccta gatgatgtgt     1020

gggcgcgcac ctcatccaag tctcttctaa cgctaacata tttgtcttta ccttttttaa     1080

atcttttttt aaatttaaat tttatgtgtg tgagtgtttt gcctgcctgt atgcacacgt     1140

gtgtgtgtgt gtgtgtgtga cactcctgat gcctgaggag gtcagaagag aaagggttgg     1200

ttccataaga actggagtta tggatggctg tgagcctttg tgtgggtgct aggaatcaaa     1260

cctgggtcct ctacaagggc agccagtgct cttaaccact gagtcagctt tccagccctg     1320

ccctggacag tttttaaaat ttaacttaat tttttttttt ttttacttaa gcccttaaca     1380

tttttaatag gactgtggga agatcaattt ctagattctc cttaacaata tacatcatat     1440

acatatacac atacatatac atatacatat atattctgag aaaatgacag tttcagttgg     1500

atctcataga ccaatggtcc agttaaaata actgtaaaat cagtgtgtgt gtgtgtgtgt     1560

gtgtgtgtgt gcaaatatga tgcatgacaa tagccataag atgcagtata ttaccctatc     1620

ccattttcct ttggtttctc actcactata ataacacctc cactgtctga agggggagac     1680

ccatgcatcc ctgtctggag gaagcctgac agattttgag gggaatcttc agagcagttc     1740

aagggcctgc ttctcctgtt tcctctgtgt caggcttttc aataaaaagg ccgtttagga     1800

aagggacaaa gcactgtgag gtggggaaca cctgtgaact cacagtagga acgcggcctt     1860

ccagtccacc atgggcagac atggctgccg cttgcctctg catgactcct ggacagctca     1920

agagctgaga atggttgtta cttttcttta ttttgagaca gcacctccct ctgtagtgct     1980

ggctggcctg gaagtcacag aaatcctcct gcctctgctt ccagagtact gggtcttaaa     2040

ctgttcacca cgtctcccct ccccaacccc caaactagcc tttccatttt taaaagccag     2100

ctaaaaatat taaagttgtg ctcttacaaa agtc                                 2134


<210>  3
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  4
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer used for K14-4-1BB amplification

<400>  5
caatgatata cactgtttga gatg                                              24


<210>  6
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer used for K14-4-1BB amplification

<400>  6
gatagtacat cacactcata gcctcctcc                                         29


