                         SEQUENCE LISTING

<110>  Syddansk Universitet
 
<120>  RAS Exon 2 skipping for cancer treatment

<130>  P1362DK00

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oliogonucleotide

<400>  1
cugccaagga gggcccugcu cagcc                                             25


<210>  2
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  2
cgcacucuug cccacaccgc cggcg                                             25


<210>  3
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  3
cucaccucua uagugggguc guauu                                             25


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  4
uugcccacac cgccggcgcc c                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oliognucleotide

<400>  5
uugcccacac cgacggcgcc c                                                 21


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  6
uauagugggg ucguauucgu ccaca                                             25


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  7
ugguucugga ucagcuggau gguca                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  8
cgggguccuc cuacaggguc uccug                                             25


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  9
gucaucgcuc cucaggggcc ugcgg                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  10
cccaccacca ccagcuuaua uuccg                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  11
gggucuccug ccccaccugc caagg                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  12
uucagucauu uucagcaggc cuuau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  13
uuuaccucua uuguuggauc auauu                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  14
augaaaaugg ucagagaaac cuuua                                             25


<210>  15
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  15
ucuguaucaa agaauggucc ugcac                                             25


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  16
caguaauaug cauauuaaaa caaga                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  17
aauaaaaaua augaaaaugu gacua                                             25


<210>  18
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  18
uauuagaaca ugucacacau aaggu                                             25


<210>  19
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  19
aguuuauauu cagucauuuu cagca                                             25


<210>  20
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  20
uacgccacca gcuccaacua ccaca                                             25


<210>  21
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  21
gcuguaucgu caaggcacuc uugcc                                             25


<210>  22
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  22
ucguccacaa aaugauucug aauua                                             25


<210>  23
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  23
uuucacacca gcaagaaccu guugg                                             25


<210>  24
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  24
ccucaccucu auggugggau cauau                                             25


<210>  25
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  25
accaccaguu uguacucagu cauuu                                             25


<210>  26
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotides

<400>  26
caacaccacc ugcuccaacc accac                                             25


<210>  27
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotides

<400>  27
gugcgcuuuu cccaacacca ccugc                                             25


<210>  28
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  28
ugguucugga uuagcuggau uguca                                             25


<210>  29
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  29
ggugggauca uauucaucua caaag                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  30
aaucaggguu aauuggcgag ccaca                                             25


<210>  31
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  31
caggaucagg ucagcgggcu accac                                             25


<210>  32
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  32
gacgaaucag gguucagggu                                                   20


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  33
caggguucag gguuagagg                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  34
gacgaauagg gauuaggga                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  35
uagggauuag ggauagagg                                                    19


<210>  36
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  36
gacgaaucag gguuucaggg u                                                 21


<210>  37
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  37
caggguuuca ggguuagagg                                                   20


<210>  38
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  38
gcgcccaggg ugu                                                          13


<210>  39
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  39
cagggugugg gca                                                          13


<210>  40
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  40
gcgccuaggg agu                                                          13


<210>  41
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tail sequence

<400>  41
cuagggagug ggca                                                         14


<210>  42
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  control splice shifting oligonucleotide

<400>  42
gcucaauaug cuacugccau gcuug                                             25


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
aggctcagcg gctcccaggt g                                                 21


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
gagtccttaa ctcttttaat ttgttctcta taatgg                                 36


<210>  45
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
ggccccgcta gcagtcgcgc ctgtgaa                                           27


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
cgtttgatct gctccctgta c                                                 21


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
attaatacga ctcactatag gg                                                22


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
cgtttgatct gctccctgta c                                                 21


<210>  49
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
ctaaatctgt ccaaagcaga ggcagtggag c                                      31


<210>  50
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
tcttttactc gcttaatctg ctccctgtag aggtt                                  35


<210>  51
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  affinity sequence

<400>  51
ggugggcgcc ggcggugugg gc                                                22


<210>  52
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  affinity seqquence

<400>  52
ggugggcgcc gucggugugg gc                                                22


<210>  53
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  affinity sequence

<400>  53
ggugggcgcc gugggugugg gc                                                22


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gtgaaggact cgagtgacgt gcccat                                            26


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
cgtttgatct gctcctgtac                                                   20


<210>  56
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  56
GUAUUCGUCC ACAAAAUGGU UCUGG                                             25


<210>  57
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  57
UUCGUCCACA AAAUGGUUCU                                                   20


<210>  58
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  58
GUAUUCGUCC ACAAAGUGGU UCUGG                                             25


<210>  59
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  59
UUCGUCCACA AAGUGGUUCU                                                   20


<210>  60
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  60
GCCUACGCCA CCAGCUCCAA CUACC                                             25


<210>  61
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  61
CUUGCCUACG CCACCAGCUC CAACU                                             25


<210>  62
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  62
ACUCUUGCCU ACGCCACCAG CUCCA                                             25


<210>  63
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  63
GGCACUCUUG CCUACGCCAC CAGCU                                             25


<210>  64
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  64
CAAGGCACUC UUGCCUACGC CACCA                                             25


<210>  65
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  65
CGUCAAGGCA CUCUUGCCUA CGCCA                                             25


<210>  66
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  66
UAUCGUCAAG GCACUCUUGC CUACG                                             25


<210>  67
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  67
GCCACCAGCU CCAACUACCA CAAGU                                             25


<210>  68
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  68
UACGCCACCA GCUCCAACUA CC                                                22


<210>  69
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  69
GCCUACGCCA CCAGCUCCAA CU                                                22


<210>  70
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  70
CUUGCCUACG CCACCAGCUC CA                                                22


<210>  71
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  71
ACUCUUGCCU ACGCCACCAG CU                                                22


<210>  72
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  72
GGCACUCUUG CCUACGCCAC CA                                                22


<210>  73
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  73
CAAGGCACUC UUGCCUACGC CA                                                22


<210>  74
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  74
CUUGCCUACG CCAUCAGCUC                                                   20


<210>  75
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  splice shifting oligonucleotide

<400>  75
UUCGUCCACA AAAUGAUUCU                                                   20


<210>  76
<211>  270
<212>  DNA
<213>  Genomic Sequence

<220>
<223>  HRAS exon 2 and flanking sequences

<400>  76
ccctgtgggg cctggggctg ggcctgggcc tggctgagca gggccctcct 
tggcaggtgg ggcaggagac cctgtaggag gaccccgggc cgcaggcccc
tgaggagcga tgacggaata taagctggtg gtggtgggcg ccggcggtgt
gggcaagagt gcgctgacca tccagctgat ccagaaccat tttgtggacg
aatacgaccc cactatagag gtgagcctgg cgccgccgtc caggtgccag
cagctgctgc gggcgagccc                                                  270


<210>  77
<211>  260
<212>  DNA
<213>  Genomic Sequence

<220>
<223>  KRAS exon2 and flanking sequences

<400>  77
ggagtatttg atagtgtatt aaccttatgt gtgacatgtt ctaatatagt
cacattttca ttatttttat tataaggcct gctgaaaatg actgaatata
aacttgtggt agttggagct ggtggcgtag gcaagagtgc cttgacgata
cagctaattc agaatcattt tgtggacgaa tatgatccaa caatagaggt
aaatcttgtt ttaatatgca tattactggt gcaggaccat tctttgatac
agataaaggt                                                             260


<210>  78
<211>  260
<212>  DNA
<213>  Genomic Sequence

<220>
<223>  NRAS exon2 and flanking sequences

<400>  78
ctttaaagta ctgtagatgt ggctcgccaa ttaaccctga ttactggttt
ccaacaggtt cttgctggtg tgaaatgact gagtacaaac tggtggtggt
tggagcaggt ggtgttggga aaagcgcact gacaatccag ctaatccaga
accactttgt agatgaatat gatcccacca tagaggtgag gcccagtggt
agcccgctga cctgatcctg tctctcactt gtcggatcat ctttacccat
attctgtatt                                                             260