                         б

<110>  йѧԺϺѧоԺ
 
<120>  ׼ƶ෢Ӳе;

<130>  136653

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2436
<212>  DNA
<213>  ˹

<220>
<223>  Fc-ECM1ںϵױ

<400>  1
atgctactag taaatcagtc acaccaaggc ttcaataagg aacacacaag caagatggta       60

agcgctattg ttttatatgt gcttttggcg gcggcggcgc attctgcctt tgcgggatcc      120

gcctctgagg gagccttcaa ggcttcagac cagcgagaga tgacgccaga gcgcctcttc      180

cagcacctcc atgaagtagg ttatgcagca cccccttccc caccacaaac ccggagactc      240

cgagttgacc actctgtaac ttctctgcat gaccctcccc tctttgagga acaaagagaa      300

gtgcagcccc cttcctctcc agaagacatc cctgtgtacg aggaagactg gcccactttc      360

ctaaacccta atgtagataa agctggtcct gctgtccctc aagaagccat ccccctgcag      420

aaagagcagc cccctcccca agtccatatt gaacagaagg aaatagaccc gcctgcccag      480

cctcaggagg agattgtcca gaaagaggtg aagccacaca ccttggcggg ccagctccct      540

ccagagcccc ggacttggaa tccagcccgt cactgccagc agggacggag aggtgtctgg      600

ggccaccggc tggatggctt ccctcctgga cggccttctc cagacaatct gaagcagatc      660

tgccttcctg agcgtcagca tgtgatctac ggcccctgga acctgccgca gactggctac      720

tctcacctta gtcgccaggg agagaccctc aatgtgctgg agaccggata ctcccgctgc      780

tgtcgctgcc gcagcgacac aaaccgccta gactgtttga agcttgtgtg ggaggatgca      840

atgacccaat tttgtgaggc cgaattctct gtcaagaccc gcccccacct gtgctgcaga      900

ctgcgtgggg aggagcgatt ctcttgcttc cagaaggaag ctcctcgccc agactacctg      960

ctccgaccct gccccgtcca ccagaatggc atgtcctcag ggccccagtt gcctttcccc     1020

ccggggttgc ccacaccgga caatgtcaaa aacatctgtc tcctgagacg cttccgcgcc     1080

gtgccacgca acctcccagc tactgacgcc atccagaggc agctgcaggc tctgactcgg     1140

ctggagacgg agttccagcg ctgctgccgc cagggccaca accacacttg cacatggaag     1200

gcctgggagg gtaccctgga tggatactgc gagcgggagc tggctataaa gacccacccc     1260

cactcgtgct gccactaccc tcctagtcct gcccgtgatg agtgcttcgc ccacctagct     1320

ccctatccca actatgaccg ggatatcttg acccttgacc tcagccgagt cacccccaac     1380

ctcatgggcc agctctgtgg aagtggaagg gtccttagca agcataaaca gattccgggg     1440

ctgatccaga atatgaccat ccgctgctgc gagcttccat atccagaaca ggcctgctgc     1500

ggcgaagagg agaaactggc cttcatcgag aacctctgtg gtccccggag gaattcgtgg     1560

aaagaccctg ccctctgctg tgacctgtct cctgaagata agcaaatcaa ctgcttcaat     1620

accaactacc tgaggaacgt ggctttagtg gctggagaca ctgggaatgc cactggcttg     1680

ggggagcagg gcccaactcg gggaacagat gccaaccccg cccctgggtc caaggaagaa     1740

ctcgagacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1800

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1860

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1920

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1980

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     2040

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     2100

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2160

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2220

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2280

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2340

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2400

ctgtctccgg gtaaaaagct tgtcgagaag tactag                               2436


<210>  2
<211>  811
<212>  PRT
<213>  ˹

<220>
<223>  Fc-ECM1ںϵ

<400>  2

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Gly Ser Ala Ser Glu Gly Ala Phe Lys Ala 
        35                  40                  45              


Ser Asp Gln Arg Glu Met Thr Pro Glu Arg Leu Phe Gln His Leu His 
    50                  55                  60                  


Glu Val Gly Tyr Ala Ala Pro Pro Ser Pro Pro Gln Thr Arg Arg Leu 
65                  70                  75                  80  


Arg Val Asp His Ser Val Thr Ser Leu His Asp Pro Pro Leu Phe Glu 
                85                  90                  95      


Glu Gln Arg Glu Val Gln Pro Pro Ser Ser Pro Glu Asp Ile Pro Val 
            100                 105                 110         


Tyr Glu Glu Asp Trp Pro Thr Phe Leu Asn Pro Asn Val Asp Lys Ala 
        115                 120                 125             


Gly Pro Ala Val Pro Gln Glu Ala Ile Pro Leu Gln Lys Glu Gln Pro 
    130                 135                 140                 


Pro Pro Gln Val His Ile Glu Gln Lys Glu Ile Asp Pro Pro Ala Gln 
145                 150                 155                 160 


Pro Gln Glu Glu Ile Val Gln Lys Glu Val Lys Pro His Thr Leu Ala 
                165                 170                 175     


Gly Gln Leu Pro Pro Glu Pro Arg Thr Trp Asn Pro Ala Arg His Cys 
            180                 185                 190         


Gln Gln Gly Arg Arg Gly Val Trp Gly His Arg Leu Asp Gly Phe Pro 
        195                 200                 205             


Pro Gly Arg Pro Ser Pro Asp Asn Leu Lys Gln Ile Cys Leu Pro Glu 
    210                 215                 220                 


Arg Gln His Val Ile Tyr Gly Pro Trp Asn Leu Pro Gln Thr Gly Tyr 
225                 230                 235                 240 


Ser His Leu Ser Arg Gln Gly Glu Thr Leu Asn Val Leu Glu Thr Gly 
                245                 250                 255     


Tyr Ser Arg Cys Cys Arg Cys Arg Ser Asp Thr Asn Arg Leu Asp Cys 
            260                 265                 270         


Leu Lys Leu Val Trp Glu Asp Ala Met Thr Gln Phe Cys Glu Ala Glu 
        275                 280                 285             


Phe Ser Val Lys Thr Arg Pro His Leu Cys Cys Arg Leu Arg Gly Glu 
    290                 295                 300                 


Glu Arg Phe Ser Cys Phe Gln Lys Glu Ala Pro Arg Pro Asp Tyr Leu 
305                 310                 315                 320 


Leu Arg Pro Cys Pro Val His Gln Asn Gly Met Ser Ser Gly Pro Gln 
                325                 330                 335     


Leu Pro Phe Pro Pro Gly Leu Pro Thr Pro Asp Asn Val Lys Asn Ile 
            340                 345                 350         


Cys Leu Leu Arg Arg Phe Arg Ala Val Pro Arg Asn Leu Pro Ala Thr 
        355                 360                 365             


Asp Ala Ile Gln Arg Gln Leu Gln Ala Leu Thr Arg Leu Glu Thr Glu 
    370                 375                 380                 


Phe Gln Arg Cys Cys Arg Gln Gly His Asn His Thr Cys Thr Trp Lys 
385                 390                 395                 400 


Ala Trp Glu Gly Thr Leu Asp Gly Tyr Cys Glu Arg Glu Leu Ala Ile 
                405                 410                 415     


Lys Thr His Pro His Ser Cys Cys His Tyr Pro Pro Ser Pro Ala Arg 
            420                 425                 430         


Asp Glu Cys Phe Ala His Leu Ala Pro Tyr Pro Asn Tyr Asp Arg Asp 
        435                 440                 445             


Ile Leu Thr Leu Asp Leu Ser Arg Val Thr Pro Asn Leu Met Gly Gln 
    450                 455                 460                 


Leu Cys Gly Ser Gly Arg Val Leu Ser Lys His Lys Gln Ile Pro Gly 
465                 470                 475                 480 


Leu Ile Gln Asn Met Thr Ile Arg Cys Cys Glu Leu Pro Tyr Pro Glu 
                485                 490                 495     


Gln Ala Cys Cys Gly Glu Glu Glu Lys Leu Ala Phe Ile Glu Asn Leu 
            500                 505                 510         


Cys Gly Pro Arg Arg Asn Ser Trp Lys Asp Pro Ala Leu Cys Cys Asp 
        515                 520                 525             


Leu Ser Pro Glu Asp Lys Gln Ile Asn Cys Phe Asn Thr Asn Tyr Leu 
    530                 535                 540                 


Arg Asn Val Ala Leu Val Ala Gly Asp Thr Gly Asn Ala Thr Gly Leu 
545                 550                 555                 560 


Gly Glu Gln Gly Pro Thr Arg Gly Thr Asp Ala Asn Pro Ala Pro Gly 
                565                 570                 575     


Ser Lys Glu Glu Leu Glu Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            580                 585                 590         


Leu Gly Gly Pro Ser Val Pro Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        595                 600                 605             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    610                 615                 620                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
625                 630                 635                 640 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                645                 650                 655     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            660                 665                 670         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        675                 680                 685             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    690                 695                 700                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
705                 710                 715                 720 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                725                 730                 735     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            740                 745                 750         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        755                 760                 765             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    770                 775                 780                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
785                 790                 795                 800 


Leu Ser Pro Gly Lys Lys Leu Val Glu Lys Tyr 
                805                 810     


