                               SEQUENCE LISTING

<110> SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
 
<120> GLUCOCORTICOID INHIBITORS FOR TREATMENT OF PROSTATE CANCER

<130> 2003080-0784

<140> PCT/US2014/069584
<141> 2014-12-11

<150> 61/914,917
<151> 2013-12-11

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 919
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln 
                85                  90                  95      


Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln 
            100                 105                 110         


Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly 
        115                 120                 125             


Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro 
    130                 135                 140                 


Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser 
                165                 170                 175     


Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu 
            180                 185                 190         


Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg 
        195                 200                 205             


Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu 
    210                 215                 220                 


Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala 
225                 230                 235                 240 


Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser 
                245                 250                 255     


Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly 
            260                 265                 270         


Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys 
        275                 280                 285             


Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr 
    290                 295                 300                 


Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly 
305                 310                 315                 320 


Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr 
                325                 330                 335     


Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp 
            340                 345                 350         


Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala 
        355                 360                 365             


Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg 
    370                 375                 380                 


Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly 
                405                 410                 415     


Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser 
            420                 425                 430         


Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr 
465                 470                 475                 480 


Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe 
                485                 490                 495     


Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro 
            500                 505                 510         


Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp 
        515                 520                 525             


Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp 
    530                 535                 540                 


His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu 
545                 550                 555                 560 


Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys 
                565                 570                 575     


Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys 
            580                 585                 590         


Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg 
        595                 600                 605             


Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met 
    610                 615                 620                 


Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln 
625                 630                 635                 640 


Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr 
                645                 650                 655     


Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile 
            660                 665                 670         


Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly 
        675                 680                 685             


His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu 
    690                 695                 700                 


Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys 
705                 710                 715                 720 


Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val 
                725                 730                 735     


Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg 
            740                 745                 750         


Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu 
        755                 760                 765             


Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys 
    770                 775                 780                 


Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr 
785                 790                 795                 800 


Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile 
                805                 810                 815     


Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met 
            820                 825                 830         


Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn 
        835                 840                 845             


Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    850                 855                 860                 


Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu 
865                 870                 875                 880 


Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala 
                885                 890                 895     


Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys 
            900                 905                 910         


Pro Ile Tyr Phe His Thr Gln 
        915                 


<210> 2
<211> 3569
<212> DNA
<213> Homo sapiens

<400> 2
taataactca gttcttattt gcacctactt cagtggacac tgaatttgga aggtggagga       60

ttttgttttt ttcttttaag atctgggcat cttttgaatc tacccttcaa gtattaagag      120

acagactgtg agcctagcag ggcagatctt gtccaccgtg tgtcttcttc tgcacgagac      180

tttgaggctg tcagagcgct ttttgcgtgg ttgctcccgc aagtttcctt ctctggagct      240

tcccgcaggt gggcagctag ctgcagcgac taccgcatca tcacagcctg ttgaactctt      300

ctgagcaaga gaaggggagg cggggtaagg gaagtaggtg gaagattcag ccaagctcaa      360

ggatggaagt gcagttaggg ctgggaaggg tctaccctcg gccgccgtcc aagacctacc      420

gaggagcttt ccagaatctg ttccagagcg tgcgcgaagt gatccagaac ccgggcccca      480

ggcacccaga ggccgcgagc gcagcacctc ccggcgccag tttgctgctg ctgcagcagc      540

agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcaagaga      600

ctagccccag gcagcagcag cagcagcagg gtgaggatgg ttctccccaa gcccatcgta      660

gaggccccac aggctacctg gtcctggatg aggaacagca accttcacag ccgcagtcgg      720

ccctggagtg ccaccccgag agaggttgcg tcccagagcc tggagccgcc gtggccgcca      780

gcaaggggct gccgcagcag ctgccagcac ctccggacga ggatgactca gctgccccat      840

ccacgttgtc cctgctgggc cccactttcc ccggcttaag cagctgctcc gctgacctta      900

aagacatcct gagcgaggcc agcaccatgc aactccttca gcaacagcag caggaagcag      960

tatccgaagg cagcagcagc gggagagcga gggaggcctc gggggctccc acttcctcca     1020

aggacaatta cttagggggc acttcgacca tttctgacaa cgccaaggag ttgtgtaagg     1080

cagtgtcggt gtccatgggc ctgggtgtgg aggcgttgga gcatctgagt ccaggggaac     1140

agcttcgggg ggattgcatg tacgccccac ttttgggagt tccacccgct gtgcgtccca     1200

ctccttgtgc cccattggcc gaatgcaaag gttctctgct agacgacagc gcaggcaaga     1260

gcactgaaga tactgctgag tattcccctt tcaagggagg ttacaccaaa gggctagaag     1320

gcgagagcct aggctgctct ggcagcgctg cagcagggag ctccgggaca cttgaactgc     1380

cgtctaccct gtctctctac aagtccggag cactggacga ggcagctgcg taccagagtc     1440

gcgactacta caactttcca ctggctctgg ccggaccgcc gccccctccg ccgcctcccc     1500

atccccacgc tcgcatcaag ctggagaacc cgctggacta cggcagcgcc tgggcggctg     1560

cggcggcgca gtgccgctat ggggacctgg cgagcctgca tggcgcgggt gcagcgggac     1620

ccggttctgg gtcaccctca gccgccgctt cctcatcctg gcacactctc ttcacagccg     1680

aagaaggcca gttgtatgga ccgtgtggtg gtggtggggg tggtggcggc ggcggcggcg     1740

gcggcggcgg cggcggcggc ggcggcggcg gcggcggcga ggcgggagct gtagccccct     1800

acggctacac tcggccccct caggggctgg cgggccagga aagcgacttc accgcacctg     1860

atgtgtggta ccctggcggc atggtgagca gagtgcccta tcccagtccc acttgtgtca     1920

aaagcgaaat gggcccctgg atggatagct actccggacc ttacggggac atgcgtttgg     1980

agactgccag ggaccatgtt ttgcccattg actattactt tccaccccag aagacctgcc     2040

tgatctgtgg agatgaagct tctgggtgtc actatggagc tctcacatgt ggaagctgca     2100

aggtcttctt caaaagagcc gctgaaggga aacagaagta cctgtgcgcc agcagaaatg     2160

attgcactat tgataaattc cgaaggaaaa attgtccatc ttgtcgtctt cggaaatgtt     2220

atgaagcagg gatgactctg ggagcccgga agctgaagaa acttggtaat ctgaaactac     2280

aggaggaagg agaggcttcc agcaccacca gccccactga ggagacaacc cagaagctga     2340

cagtgtcaca cattgaaggc tatgaatgtc agcccatctt tctgaatgtc ctggaagcca     2400

ttgagccagg tgtagtgtgt gctggacacg acaacaacca gcccgactcc tttgcagcct     2460

tgctctctag cctcaatgaa ctgggagaga gacagcttgt acacgtggtc aagtgggcca     2520

aggccttgcc tggcttccgc aacttacacg tggacgacca gatggctgtc attcagtact     2580

cctggatggg gctcatggtg tttgccatgg gctggcgatc cttcaccaat gtcaactcca     2640

ggatgctcta cttcgcccct gatctggttt tcaatgagta ccgcatgcac aagtcccgga     2700

tgtacagcca gtgtgtccga atgaggcacc tctctcaaga gtttggatgg ctccaaatca     2760

ccccccagga attcctgtgc atgaaagcac tgctactctt cagcattatt ccagtggatg     2820

ggctgaaaaa tcaaaaattc tttgatgaac ttcgaatgaa ctacatcaag gaactcgatc     2880

gtatcattgc atgcaaaaga aaaaatccca catcctgctc aagacgcttc taccagctca     2940

ccaagctcct ggactccgtg cagcctattg cgagagagct gcatcagttc acttttgacc     3000

tgctaatcaa gtcacacatg gtgagcgtgg actttccgga aatgatggca gagatcatct     3060

ctgtgcaagt gcccaagatc ctttctggga aagtcaagcc catctatttc cacacccagt     3120

gaagcattgg aaaccctatt tccccacccc agctcatgcc ccctttcaga tgtcttctgc     3180

ctgttataac tctgcactac tcctctgcag tgccttgggg aatttcctct attgatgtac     3240

agtctgtcat gaacatgttc ctgaattcta tttgctgggc tttttttttc tctttctctc     3300

ctttcttttt cttcttccct ccctatctaa ccctcccatg gcaccttcag actttgcttc     3360

ccattgtggc tcctatctgt gttttgaatg gtgttgtatg cctttaaatc tgtgatgatc     3420

ctcatatggc ccagtgtcaa gttgtgcttg tttacagcac tactctgtgc cagccacaca     3480

aacgtttact tatcttatgc cacgggaagt ttagagagct aagattatct ggggaaatca     3540

aaacaaaaaa caagcaaaca aaaaaaaaa                                       3569


<210> 3
<211> 777
<212> PRT
<213> Homo sapiens

<400> 3
Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         


<210> 4
<211> 751
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Phe Tyr Lys Thr Leu Arg Gly Gly Ala Thr Val Lys Val Ser 
1               5                   10                  15      


Ala Ser Ser Pro Ser Leu Ala Val Ala Ser Gln Ser Asp Ser Lys Gln 
            20                  25                  30          


Arg Arg Leu Leu Val Asp Phe Pro Lys Gly Ser Val Ser Asn Ala Gln 
        35                  40                  45              


Gln Pro Asp Leu Ser Lys Ala Val Ser Leu Ser Met Gly Leu Tyr Met 
    50                  55                  60                  


Gly Glu Thr Glu Thr Lys Val Met Gly Asn Asp Leu Gly Phe Pro Gln 
65                  70                  75                  80  


Gln Gly Gln Ile Ser Leu Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu 
                85                  90                  95      


Glu Glu Ser Ile Ala Asn Leu Asn Arg Ser Thr Ser Val Pro Glu Asn 
            100                 105                 110         


Pro Lys Ser Ser Ala Ser Thr Ala Val Ser Ala Ala Pro Thr Glu Lys 
        115                 120                 125             


Glu Phe Pro Lys Thr His Ser Asp Val Ser Ser Glu Gln Gln His Leu 
    130                 135                 140                 


Lys Gly Gln Thr Gly Thr Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr 
145                 150                 155                 160 


Asp Gln Ser Thr Phe Asp Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly 
                165                 170                 175     


Ser Pro Gly Lys Glu Thr Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu 
            180                 185                 190         


Ile Asp Glu Asn Cys Leu Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser 
        195                 200                 205             


Phe Leu Leu Glu Gly Asn Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu 
    210                 215                 220                 


Pro Asp Thr Lys Pro Lys Ile Lys Asp Asn Gly Asp Leu Val Leu Ser 
225                 230                 235                 240 


Ser Pro Ser Asn Val Thr Leu Pro Gln Val Lys Thr Glu Lys Glu Asp 
                245                 250                 255     


Phe Ile Glu Leu Cys Thr Pro Gly Val Ile Lys Gln Glu Lys Leu Gly 
            260                 265                 270         


Thr Val Tyr Cys Gln Ala Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn 
        275                 280                 285             


Lys Met Ser Ala Ile Ser Val His Gly Val Ser Thr Ser Gly Gly Gln 
    290                 295                 300                 


Met Tyr His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp 
305                 310                 315                 320 


Gln Lys Pro Ile Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu 
                325                 330                 335     


Asn Trp Asn Arg Cys Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu 
            340                 345                 350         


Gly Thr Leu Asn Phe Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser 
        355                 360                 365             


Ser Pro Ser Met Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser 
    370                 375                 380                 


Thr Ala Thr Thr Gly Pro Pro Pro Lys Leu Cys Leu Val Cys Ser Asp 
385                 390                 395                 400 


Glu Ala Ser Gly Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys 
                405                 410                 415     


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
            420                 425                 430         


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
        435                 440                 445             


Ala Cys Arg Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala 
    450                 455                 460                 


Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly 
465                 470                 475                 480 


Val Ser Gln Glu Thr Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro 
                485                 490                 495     


Ala Thr Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val 
            500                 505                 510         


Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp 
        515                 520                 525             


Ser Thr Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln 
    530                 535                 540                 


Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn 
545                 550                 555                 560 


Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe 
                565                 570                 575     


Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala 
            580                 585                 590         


Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met 
        595                 600                 605             


Thr Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser 
    610                 615                 620                 


Ser Glu Leu His Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met 
625                 630                 635                 640 


Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser 
                645                 650                 655     


Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly 
            660                 665                 670         


Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg 
        675                 680                 685             


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val Glu 
    690                 695                 700                 


Asn Leu Leu Asn Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser 
705                 710                 715                 720 


Ile Glu Phe Pro Glu Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro 
                725                 730                 735     


Lys Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
            740                 745                 750     


<210> 5
<211> 692
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys Val Met Gly Asn Asp 
1               5                   10                  15      


Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu Ser Ser Gly Glu Thr 
            20                  25                  30          


Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn Leu Asn Arg Ser Thr 
        35                  40                  45              


Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser Thr Ala Val Ser Ala 
    50                  55                  60                  


Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His Ser Asp Val Ser Ser 
65                  70                  75                  80  


Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr Asn Gly Gly Asn Val 
                85                  90                  95      


Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp Ile Leu Gln Asp Leu 
            100                 105                 110         


Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr Asn Glu Ser Pro Trp 
        115                 120                 125             


Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu Leu Ser Pro Leu Ala 
    130                 135                 140                 


Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn Ser Asn Glu Asp Cys 
145                 150                 155                 160 


Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys Ile Lys Asp Asn Gly 
                165                 170                 175     


Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr Leu Pro Gln Val Lys 
            180                 185                 190         


Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr Pro Gly Val Ile Lys 
        195                 200                 205             


Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala Ser Phe Pro Gly Ala 
    210                 215                 220                 


Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser Val His Gly Val Ser 
225                 230                 235                 240 


Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met Asn Thr Ala Ser Leu 
                245                 250                 255     


Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn Val Ile Pro Pro Ile 
            260                 265                 270         


Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln Gly Ser Gly Asp Asp 
        275                 280                 285             


Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro Gly Arg Thr Val Phe 
    290                 295                 300                 


Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro Asp Val Ser Ser Pro 
305                 310                 315                 320 


Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro Pro Pro Lys Leu Cys 
                325                 330                 335     


Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His Tyr Gly Val Leu Thr 
            340                 345                 350         


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Val Glu Gly Gln His 
        355                 360                 365             


Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg 
    370                 375                 380                 


Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys Cys Leu Gln Ala Gly 
385                 390                 395                 400 


Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln 
                405                 410                 415     


Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser Glu Asn Pro Gly Asn 
            420                 425                 430         


Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu Thr Pro Thr Leu Val 
        435                 440                 445             


Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp 
    450                 455                 460                 


Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr Leu Asn Met 
465                 470                 475                 480 


Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile 
                485                 490                 495     


Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln 
            500                 505                 510         


Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr 
        515                 520                 525             


Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile 
    530                 535                 540                 


Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln Cys Lys His 
545                 550                 555                 560 


Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val Ser Tyr Glu 
                565                 570                 575     


Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys 
            580                 585                 590         


Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr 
        595                 600                 605             


Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser 
    610                 615                 620                 


Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met 
625                 630                 635                 640 


His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln Thr Phe Leu 
                645                 650                 655     


Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala Glu Ile Ile 
            660                 665                 670         


Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu 
        675                 680                 685             


Phe His Gln Lys 
    690         


<210> 6
<211> 688
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Glu Thr Glu Thr Lys Val Met Gly Asn Asp Leu Gly Phe Pro 
1               5                   10                  15      


Gln Gln Gly Gln Ile Ser Leu Ser Ser Gly Glu Thr Asp Leu Lys Leu 
            20                  25                  30          


Leu Glu Glu Ser Ile Ala Asn Leu Asn Arg Ser Thr Ser Val Pro Glu 
        35                  40                  45              


Asn Pro Lys Ser Ser Ala Ser Thr Ala Val Ser Ala Ala Pro Thr Glu 
    50                  55                  60                  


Lys Glu Phe Pro Lys Thr His Ser Asp Val Ser Ser Glu Gln Gln His 
65                  70                  75                  80  


Leu Lys Gly Gln Thr Gly Thr Asn Gly Gly Asn Val Lys Leu Tyr Thr 
                85                  90                  95      


Thr Asp Gln Ser Thr Phe Asp Ile Leu Gln Asp Leu Glu Phe Ser Ser 
            100                 105                 110         


Gly Ser Pro Gly Lys Glu Thr Asn Glu Ser Pro Trp Arg Ser Asp Leu 
        115                 120                 125             


Leu Ile Asp Glu Asn Cys Leu Leu Ser Pro Leu Ala Gly Glu Asp Asp 
    130                 135                 140                 


Ser Phe Leu Leu Glu Gly Asn Ser Asn Glu Asp Cys Lys Pro Leu Ile 
145                 150                 155                 160 


Leu Pro Asp Thr Lys Pro Lys Ile Lys Asp Asn Gly Asp Leu Val Leu 
                165                 170                 175     


Ser Ser Pro Ser Asn Val Thr Leu Pro Gln Val Lys Thr Glu Lys Glu 
            180                 185                 190         


Asp Phe Ile Glu Leu Cys Thr Pro Gly Val Ile Lys Gln Glu Lys Leu 
        195                 200                 205             


Gly Thr Val Tyr Cys Gln Ala Ser Phe Pro Gly Ala Asn Ile Ile Gly 
    210                 215                 220                 


Asn Lys Met Ser Ala Ile Ser Val His Gly Val Ser Thr Ser Gly Gly 
225                 230                 235                 240 


Gln Met Tyr His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln Gln 
                245                 250                 255     


Asp Gln Lys Pro Ile Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser 
            260                 265                 270         


Glu Asn Trp Asn Arg Cys Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser 
        275                 280                 285             


Leu Gly Thr Leu Asn Phe Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr 
    290                 295                 300                 


Ser Ser Pro Ser Met Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser 
305                 310                 315                 320 


Ser Thr Ala Thr Thr Gly Pro Pro Pro Lys Leu Cys Leu Val Cys Ser 
                325                 330                 335     


Asp Glu Ala Ser Gly Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys 
            340                 345                 350         


Lys Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys 
        355                 360                 365             


Ala Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys 
    370                 375                 380                 


Pro Ala Cys Arg Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu 
385                 390                 395                 400 


Ala Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr 
                405                 410                 415     


Gly Val Ser Gln Glu Thr Ser Glu Asn Pro Gly Asn Lys Thr Ile Val 
            420                 425                 430         


Pro Ala Thr Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu 
        435                 440                 445             


Val Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro 
    450                 455                 460                 


Asp Ser Thr Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg 
465                 470                 475                 480 


Gln Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg 
                485                 490                 495     


Asn Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met 
            500                 505                 510         


Phe Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser 
        515                 520                 525             


Ala Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg 
    530                 535                 540                 


Met Thr Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Tyr Val 
545                 550                 555                 560 


Ser Ser Glu Leu His Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys 
                565                 570                 575     


Met Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Asp Gly Leu Lys 
            580                 585                 590         


Ser Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu 
        595                 600                 605             


Gly Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln 
    610                 615                 620                 


Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val 
625                 630                 635                 640 


Glu Asn Leu Leu Asn Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met 
                645                 650                 655     


Ser Ile Glu Phe Pro Glu Met Leu Ala Glu Ile Ile Thr Asn Gln Ile 
            660                 665                 670         


Pro Lys Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
        675                 680                 685             


<210> 7
<211> 680
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu Ser 
1               5                   10                  15      


Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn Leu 
            20                  25                  30          


Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser Thr 
        35                  40                  45              


Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His Ser 
    50                  55                  60                  


Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr Asn 
65                  70                  75                  80  


Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp Ile 
                85                  90                  95      


Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr Asn 
            100                 105                 110         


Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu Leu 
        115                 120                 125             


Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn Ser 
    130                 135                 140                 


Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys Ile 
145                 150                 155                 160 


Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr Leu 
                165                 170                 175     


Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr Pro 
            180                 185                 190         


Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala Ser 
        195                 200                 205             


Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser Val 
    210                 215                 220                 


His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met Asn 
225                 230                 235                 240 


Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn Val 
                245                 250                 255     


Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln Gly 
            260                 265                 270         


Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro Gly 
        275                 280                 285             


Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro Asp 
    290                 295                 300                 


Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro Pro 
305                 310                 315                 320 


Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His Tyr 
                325                 330                 335     


Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Val 
            340                 345                 350         


Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile Ile 
        355                 360                 365             


Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys Cys 
    370                 375                 380                 


Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys Ile 
385                 390                 395                 400 


Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser Glu 
                405                 410                 415     


Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu Thr 
            420                 425                 430         


Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr 
        435                 440                 445             


Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr 
    450                 455                 460                 


Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp 
465                 470                 475                 480 


Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met 
                485                 490                 495     


Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly 
            500                 505                 510         


Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro 
        515                 520                 525             


Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp 
    530                 535                 540                 


Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln 
545                 550                 555                 560 


Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser 
                565                 570                 575     


Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile 
            580                 585                 590         


Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu 
        595                 600                 605             


Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu 
    610                 615                 620                 


Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe 
625                 630                 635                 640 


Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu 
                645                 650                 655     


Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile 
            660                 665                 670         


Lys Lys Leu Leu Phe His Gln Lys 
        675                 680 


<210> 8
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8
Met Ser Ala Ile Ser Val His Gly Val Ser Thr Ser Gly Gly Gln Met 
1               5                   10                  15      


Tyr His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln 
            20                  25                  30          


Lys Pro Ile Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn 
        35                  40                  45              


Trp Asn Arg Cys Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly 
    50                  55                  60                  


Thr Leu Asn Phe Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser 
65                  70                  75                  80  


Pro Ser Met Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr 
                85                  90                  95      


Ala Thr Thr Gly Pro Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu 
            100                 105                 110         


Ala Ser Gly Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val 
        115                 120                 125             


Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly 
    130                 135                 140                 


Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala 
145                 150                 155                 160 


Cys Arg Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg 
                165                 170                 175     


Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val 
            180                 185                 190         


Ser Gln Glu Thr Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala 
        195                 200                 205             


Thr Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile 
    210                 215                 220                 


Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser 
225                 230                 235                 240 


Thr Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val 
                245                 250                 255     


Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu 
            260                 265                 270         


His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu 
        275                 280                 285             


Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn 
    290                 295                 300                 


Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr 
305                 310                 315                 320 


Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser 
                325                 330                 335     


Glu Leu His Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys 
            340                 345                 350         


Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln 
        355                 360                 365             


Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys 
    370                 375                 380                 


Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe 
385                 390                 395                 400 


Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn 
                405                 410                 415     


Leu Leu Asn Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile 
            420                 425                 430         


Glu Phe Pro Glu Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys 
        435                 440                 445             


Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
    450                 455                 460         


<210> 9
<211> 447
<212> PRT
<213> Homo sapiens

<400> 9
Met Tyr His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp 
1               5                   10                  15      


Gln Lys Pro Ile Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu 
            20                  25                  30          


Asn Trp Asn Arg Cys Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu 
        35                  40                  45              


Gly Thr Leu Asn Phe Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser 
    50                  55                  60                  


Ser Pro Ser Met Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser 
65                  70                  75                  80  


Thr Ala Thr Thr Gly Pro Pro Pro Lys Leu Cys Leu Val Cys Ser Asp 
                85                  90                  95      


Glu Ala Ser Gly Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys 
            100                 105                 110         


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
        115                 120                 125             


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
    130                 135                 140                 


Ala Cys Arg Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala 
145                 150                 155                 160 


Arg Lys Thr Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly 
                165                 170                 175     


Val Ser Gln Glu Thr Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro 
            180                 185                 190         


Ala Thr Leu Pro Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val 
        195                 200                 205             


Ile Glu Pro Glu Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp 
    210                 215                 220                 


Ser Thr Trp Arg Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln 
225                 230                 235                 240 


Val Ile Ala Ala Val Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn 
                245                 250                 255     


Leu His Leu Asp Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe 
            260                 265                 270         


Leu Met Ala Phe Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala 
        275                 280                 285             


Asn Leu Leu Cys Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met 
    290                 295                 300                 


Thr Leu Pro Cys Met Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser 
305                 310                 315                 320 


Ser Glu Leu His Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met 
                325                 330                 335     


Lys Thr Leu Leu Leu Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser 
            340                 345                 350         


Gln Glu Leu Phe Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly 
        355                 360                 365             


Lys Ala Ile Val Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg 
    370                 375                 380                 


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Glu Val Val Glu 
385                 390                 395                 400 


Asn Leu Leu Asn Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser 
                405                 410                 415     


Ile Glu Phe Pro Glu Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro 
            420                 425                 430         


Lys Tyr Ser Asn Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
        435                 440                 445         


<210> 10
<211> 442
<212> PRT
<213> Homo sapiens

<400> 10
Met Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe 
1               5                   10                  15      


Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys 
            20                  25                  30          


Gln Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe 
        35                  40                  45              


Pro Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg 
    50                  55                  60                  


Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly 
65                  70                  75                  80  


Pro Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys 
                85                  90                  95      


His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg 
            100                 105                 110         


Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys 
        115                 120                 125             


Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg 
    130                 135                 140                 


Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys 
145                 150                 155                 160 


Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr 
                165                 170                 175     


Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln 
            180                 185                 190         


Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val 
        195                 200                 205             


Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile 
    210                 215                 220                 


Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val 
225                 230                 235                 240 


Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp 
                245                 250                 255     


Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala 
            260                 265                 270         


Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe 
        275                 280                 285             


Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met 
    290                 295                 300                 


Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg 
305                 310                 315                 320 


Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu 
                325                 330                 335     


Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp 
            340                 345                 350         


Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys 
        355                 360                 365             


Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr 
    370                 375                 380                 


Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr 
385                 390                 395                 400 


Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu 
                405                 410                 415     


Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly 
            420                 425                 430         


Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
        435                 440         


<210> 11
<211> 676
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Gly Trp 
        675     


<210> 12
<211> 778
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Arg Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys 
    450                 455                 460                 


Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg 
465                 470                 475                 480 


Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys 
                485                 490                 495     


Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr 
            500                 505                 510         


Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln 
        515                 520                 525             


Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val 
    530                 535                 540                 


Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile 
545                 550                 555                 560 


Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val 
                565                 570                 575     


Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp 
            580                 585                 590         


Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala 
        595                 600                 605             


Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe 
    610                 615                 620                 


Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met 
625                 630                 635                 640 


Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg 
                645                 650                 655     


Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu 
            660                 665                 670         


Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp 
        675                 680                 685             


Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys 
    690                 695                 700                 


Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr 
705                 710                 715                 720 


Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr 
                725                 730                 735     


Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu 
            740                 745                 750         


Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly 
        755                 760                 765             


Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775             


<210> 13
<211> 742
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Asn Val Met Trp Leu Lys Pro Glu Ser 
                725                 730                 735     


Thr Ser His Thr Leu Ile 
            740         


<210> 14
<211> 6801
<212> DNA
<213> Homo sapiens

<400> 14
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct       60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc      120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag      180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac      240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga      300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt      360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt      420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt      480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc      540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga      600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc      660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca      720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa      780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa      840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca      900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt      960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc     1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat     1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac     1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt     1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa     1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg     1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa     1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg     1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg     1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca     1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact     1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc     1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca     1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta     1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta     1860

tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc     1920

cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa     1980

ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt     2040

aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg     2100

gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact     2160

tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa     2220

tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg     2280

cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca     2340

agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta     2400

ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt     2460

caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct     2520

aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag     2580

ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat     2640

caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct taactattgc     2700

ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt agctgaaatc     2760

atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct gtttcatcaa     2820

aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata gcttttattg     2880

tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt gttttcatct     2940

gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac ttggcaacag     3000

aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa atttattagt     3060

taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca gtcaaagaag     3120

gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct tcatactttt     3180

tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc ccccctgtat     3240

agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta caagtgtata     3300

tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac aatttccttt     3360

atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc aagttattgt     3420

acagctgttt aagatgggca gctagttcgt agctttccca aataaactct aaacattaat     3480

caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag ctatcagaag     3540

accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa aaaaagctca     3600

tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt aacagtccta     3660

actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga tggttgcaaa     3720

agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc ctatttttgc     3780

aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt ttgaagtagt     3840

ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag ctgagagact     3900

tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa tctctaatat     3960

ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg gttaatcttt     4020

cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt atgtcagaca     4080

tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca caagtcctgt     4140

gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta gccctttctg     4200

tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa gccacaagaa     4260

atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga aaatctaata     4320

ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag atatatatca     4380

tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg caatttatta     4440

aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga tgagattgtt     4500

ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg gataacctat     4560

atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa accaaacagt     4620

ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg ttgctgaggc     4680

tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga ccacccttct     4740

cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc ttgcactaaa     4800

gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta aaggcaccat     4860

ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac aacagaagct     4920

tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag tgcagaatct     4980

cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt tatttccaaa     5040

taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt tgttattttc     5100

agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa tgctctctaa     5160

aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt tggtgcctaa     5220

gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga gcttctaaaa     5280

cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc acatctcaca     5340

cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact caatgagaaa     5400

aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat cgacaactat     5460

aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg tgggggaaaa     5520

gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg tgctgtttga     5580

aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac tgttgaagtt     5640

tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta tttttagtgt     5700

ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga cataacactt     5760

ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc accccaaaag     5820

gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga tgagctctgg     5880

gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag caattccagt     5940

ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta catcaccatg     6000

gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac catggtagcc     6060

ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg tgaatgtgtt     6120

tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa ggaggacact     6180

ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa cctggtccac     6240

ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa atgtctgaaa     6300

ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa cttgcttaac     6360

tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta tataatgggg     6420

acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta ttttttatca     6480

cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa ataaaagttg     6540

tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc tttttaccta     6600

cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt attttttcat     6660

ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg cagtaaatgt     6720

tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat ctgctttttc     6780

attaaaaaaa aaaaaaaaaa a                                               6801


<210> 15
<211> 6614
<212> DNA
<213> Homo sapiens

<400> 15
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct       60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac      120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga      180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac      240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac      300

agaaagaggt tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga      360

aaaccccagc agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct      420

aagaggagga gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca      480

atcagactcc aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc      540

gcagcagcca gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac      600

agaaacaaaa gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc      660

ctcgggggaa acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac      720

cagtgttcca gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga      780

gaaggagttt ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca      840

gactggcacc aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat      900

tttgcaggat ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg      960

gagatcagac ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga     1020

ttcattcctt ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac     1080

taaacccaaa attaaggata atggagatct ggttttgtca agccccagta atgtaacact     1140

gccccaagtg aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa     1200

gcaagagaaa ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg     1260

taataaaatg tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca     1320

ctatgacatg aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt     1380

cattccacca attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga     1440

caacttgact tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta     1500

ttcaagcccc agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac     1560

aacaggacca cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta     1620

tggagtctta acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca     1680

caattaccta tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg     1740

cccagcatgc cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac     1800

aaagaaaaaa ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga     1860

aaatcctggt aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt     1920

gtcactgttg gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc     1980

agactcaact tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc     2040

agcagtgaaa tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat     2100

gaccctactg cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata     2160

tagacaatca agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag     2220

aatgactcta ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt     2280

acacaggctt caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc     2340

ttcagttcct aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta     2400

catcaaagag ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca     2460

gcggttttat caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct     2520

taactattgc ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt     2580

agctgaaatc atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct     2640

gtttcatcaa aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata     2700

gcttttattg tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt     2760

gttttcatct gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac     2820

ttggcaacag aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa     2880

atttattagt taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca     2940

gtcaaagaag gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct     3000

tcatactttt tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc     3060

ccccctgtat agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta     3120

caagtgtata tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac     3180

aatttccttt atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc     3240

aagttattgt acagctgttt aagatgggca gctagttcgt agctttccca aataaactct     3300

aaacattaat caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag     3360

ctatcagaag accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa     3420

aaaaagctca tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt     3480

aacagtccta actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga     3540

tggttgcaaa agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc     3600

ctatttttgc aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt     3660

ttgaagtagt ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag     3720

ctgagagact tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa     3780

tctctaatat ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg     3840

gttaatcttt cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt     3900

atgtcagaca tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca     3960

caagtcctgt gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta     4020

gccctttctg tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa     4080

gccacaagaa atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga     4140

aaatctaata ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag     4200

atatatatca tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg     4260

caatttatta aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga     4320

tgagattgtt ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg     4380

gataacctat atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa     4440

accaaacagt ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg     4500

ttgctgaggc tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga     4560

ccacccttct cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc     4620

ttgcactaaa gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta     4680

aaggcaccat ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac     4740

aacagaagct tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag     4800

tgcagaatct cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt     4860

tatttccaaa taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt     4920

tgttattttc agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa     4980

tgctctctaa aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt     5040

tggtgcctaa gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga     5100

gcttctaaaa cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc     5160

acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact     5220

caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat     5280

cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg     5340

tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg     5400

tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac     5460

tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta     5520

tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga     5580

cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc     5640

accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga     5700

tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag     5760

caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta     5820

catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac     5880

catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg     5940

tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa     6000

ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa     6060

cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa     6120

atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa     6180

cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta     6240

tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta     6300

ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa     6360

ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc     6420

tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt     6480

attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg     6540

cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat     6600

ctgctttttc atta                                                       6614


<210> 16
<211> 6517
<212> DNA
<213> Homo sapiens

<400> 16
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct       60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac      120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga      180

tcttctgata ccaaatcact ggaccttaga agttgatatt cactgatgga ctccaaagaa      240

tcattaactc ctggtagaga agaaaacccc agcagtgtgc ttgctcagga gaggggagat      300

gtgatggact tctataaaac cctaagagga ggagctactg tgaaggtttc tgcgtcttca      360

ccctcactgg ctgtcgcttc tcaatcagac tccaagcagc gaagactttt ggttgatttt      420

ccaaaaggct cagtaagcaa tgcgcagcag ccagatctgt ccaaagcagt ttcactctca      480

atgggactgt atatgggaga gacagaaaca aaagtgatgg gaaatgacct gggattccca      540

cagcagggcc aaatcagcct ttcctcgggg gaaacagact taaagctttt ggaagaaagc      600

attgcaaacc tcaataggtc gaccagtgtt ccagagaacc ccaagagttc agcatccact      660

gctgtgtctg ctgcccccac agagaaggag tttccaaaaa ctcactctga tgtatcttca      720

gaacagcaac atttgaaggg ccagactggc accaacggtg gcaatgtgaa attgtatacc      780

acagaccaaa gcacctttga cattttgcag gatttggagt tttcttctgg gtccccaggt      840

aaagagacga atgagagtcc ttggagatca gacctgttga tagatgaaaa ctgtttgctt      900

tctcctctgg cgggagaaga cgattcattc cttttggaag gaaactcgaa tgaggactgc      960

aagcctctca ttttaccgga cactaaaccc aaaattaagg ataatggaga tctggttttg     1020

tcaagcccca gtaatgtaac actgccccaa gtgaaaacag aaaaagaaga tttcatcgaa     1080

ctctgcaccc ctggggtaat taagcaagag aaactgggca cagtttactg tcaggcaagc     1140

tttcctggag caaatataat tggtaataaa atgtctgcca tttctgttca tggtgtgagt     1200

acctctggag gacagatgta ccactatgac atgaatacag catccctttc tcaacagcag     1260

gatcagaagc ctatttttaa tgtcattcca ccaattcccg ttggttccga aaattggaat     1320

aggtgccaag gatctggaga tgacaacttg acttctctgg ggactctgaa cttccctggt     1380

cgaacagttt tttctaatgg ctattcaagc cccagcatga gaccagatgt aagctctcct     1440

ccatccagct cctcaacagc aacaacagga ccacctccca aactctgcct ggtgtgctct     1500

gatgaagctt caggatgtca ttatggagtc ttaacttgtg gaagctgtaa agttttcttc     1560

aaaagagcag tggaaggaca gcacaattac ctatgtgctg gaaggaatga ttgcatcatc     1620

gataaaattc gaagaaaaaa ctgcccagca tgccgctatc gaaaatgtct tcaggctgga     1680

atgaacctgg aagctcgaaa aacaaagaaa aaaataaaag gaattcagca ggccactaca     1740

ggagtctcac aagaaacctc tgaaaatcct ggtaacaaaa caatagttcc tgcaacgtta     1800

ccacaactca cccctaccct ggtgtcactg ttggaggtta ttgaacctga agtgttatat     1860

gcaggatatg atagctctgt tccagactca acttggagga tcatgactac gctcaacatg     1920

ttaggagggc ggcaagtgat tgcagcagtg aaatgggcaa aggcaatacc aggtttcagg     1980

aacttacacc tggatgacca aatgacccta ctgcagtact cctggatgtt tcttatggca     2040

tttgctctgg ggtggagatc atatagacaa tcaagtgcaa acctgctgtg ttttgctcct     2100

gatctgatta ttaatgagca gagaatgact ctaccctgca tgtacgacca atgtaaacac     2160

atgctgtatg tttcctctga gttacacagg cttcaggtat cttatgaaga gtatctctgt     2220

atgaaaacct tactgcttct ctcttcagtt cctaaggacg gtctgaagag ccaagagcta     2280

tttgatgaaa ttagaatgac ctacatcaaa gagctaggaa aagccattgt caagagggaa     2340

ggaaactcca gccagaactg gcagcggttt tatcaactga caaaactctt ggattctatg     2400

catgaagtgg ttgaaaatct ccttaactat tgcttccaaa catttttgga taagaccatg     2460

agtattgaat tccccgagat gttagctgaa atcatcacca atcagatacc aaaatattca     2520

aatggaaata tcaaaaaact tctgtttcat caaaagtgac tgccttaata agaatggttg     2580

ccttaaagaa agtcgaatta atagctttta ttgtataaac tatcagtttg tcctgtagag     2640

gttttgttgt tttatttttt attgttttca tctgttgttt tgttttaaat acgcactaca     2700

tgtggtttat agagggccaa gacttggcaa cagaagcagt tgagtcgtca tcacttttca     2760

gtgatgggag agtagatggt gaaatttatt agttaatata tcccagaaat tagaaacctt     2820

aatatgtgga cgtaatctcc acagtcaaag aaggatggca cctaaaccac cagtgcccaa     2880

agtctgtgtg atgaactttc tcttcatact ttttttcaca gttggctgga tgaaattttc     2940

tagactttct gttggtgtat cccccccctg tatagttagg atagcatttt tgatttatgc     3000

atggaaacct gaaaaaaagt ttacaagtgt atatcagaaa agggaagttg tgccttttat     3060

agctattact gtctggtttt aacaatttcc tttatattta gtgaactacg cttgctcatt     3120

ttttcttaca taatttttta ttcaagttat tgtacagctg tttaagatgg gcagctagtt     3180

cgtagctttc ccaaataaac tctaaacatt aatcaatcat ctgtgtgaaa atgggttggt     3240

gcttctaacc tgatggcact tagctatcag aagaccacaa aaattgactc aaatctccag     3300

tattcttgtc aaaaaaaaaa aaaaaaaagc tcatattttg tatatatctg cttcagtgga     3360

gaattatata ggttgtgcaa attaacagtc ctaactggta tagagcacct agtccagtga     3420

cctgctgggt aaactgtgga tgatggttgc aaaagactaa tttaaaaaat aactaccaag     3480

aggccctgtc tgtacctaac gccctatttt tgcaatggct atatggcaag aaagctggta     3540

aactatttgt ctttcaggac cttttgaagt agtttgtata acttcttaaa agttgtgatt     3600

ccagataacc agctgtaaca cagctgagag acttttaatc agacaaagta attcctctca     3660

ctaaacttta cccaaaaact aaatctctaa tatggcaaaa atggctagac acccattttc     3720

acattcccat ctgtcaccaa ttggttaatc tttcctgatg gtacaggaaa gctcagctac     3780

tgatttttgt gatttagaac tgtatgtcag acatccatgt ttgtaaaact acacatccct     3840

aatgtgtgcc atagagttta acacaagtcc tgtgaatttc ttcactgttg aaaattattt     3900

taaacaaaat agaagctgta gtagcccttt ctgtgtgcac cttaccaact ttctgtaaac     3960

tcaaaactta acatatttac taagccacaa gaaatttgat ttctattcaa ggtggccaaa     4020

ttatttgtgt aatagaaaac tgaaaatcta atattaaaaa tatggaactt ctaatatatt     4080

tttatattta gttatagttt cagatatata tcatattggt attcactaat ctgggaaggg     4140

aagggctact gcagctttac atgcaattta ttaaaatgat tgtaaaatag cttgtatagt     4200

gtaaaataag aatgattttt agatgagatt gttttatcat gacatgttat atattttttg     4260

taggggtcaa agaaatgctg atggataacc tatatgattt atagtttgta catgcattca     4320

tacaggcagc gatggtctca gaaaccaaac agtttgctct aggggaagag ggagatggag     4380

actggtcctg tgtgcagtga aggttgctga ggctctgacc cagtgagatt acagaggaag     4440

ttatcctctg cctcccattc tgaccaccct tctcattcca acagtgagtc tgtcagcgca     4500

ggtttagttt actcaatctc cccttgcact aaagtatgta aagtatgtaa acaggagaca     4560

ggaaggtggt gcttacatcc ttaaaggcac catctaatag cgggttactt tcacatacag     4620

ccctccccca gcagttgaat gacaacagaa gcttcagaag tttggcaata gtttgcatag     4680

aggtaccagc aatatgtaaa tagtgcagaa tctcataggt tgccaataat acactaattc     4740

ctttctatcc tacaacaaga gtttatttcc aaataaaatg aggacatgtt tttgttttct     4800

ttgaatgctt tttgaatgtt atttgttatt ttcagtattt tggagaaatt atttaataaa     4860

aaaacaatca tttgcttttt gaatgctctc taaaagggaa tgtaatattt taagatggtg     4920

tgtaacccgg ctggataaat ttttggtgcc taagaaaact gcttgaatat tcttatcaat     4980

gacagtgtta agtttcaaaa agagcttcta aaacgtagat tatcattcct ttatagaatg     5040

ttatgtggtt aaaaccagaa agcacatctc acacattaat ctgattttca tcccaacaat     5100

cttggcgctc aaaaaataga actcaatgag aaaaagaaga ttatgtgcac ttcgttgtca     5160

ataataagtc aactgatgct catcgacaac tataggaggc ttttcattaa atgggaaaag     5220

aagctgtgcc cttttaggat acgtggggga aaagaaagtc atcttaatta tgtttaattg     5280

tggatttaag tgctatatgg tggtgctgtt tgaaagcaga tttatttcct atgtatgtgt     5340

tatctggcca tcccaaccca aactgttgaa gtttgtagta acttcagtga gagttggtta     5400

ctcacaacaa atcctgaaaa gtatttttag tgtttgtagg tattctgtgg gatactatac     5460

aagcagaact gaggcactta ggacataaca cttttggggt atatatatcc aaatgcctaa     5520

aactatggga ggaaaccttg gccaccccaa aaggaaaact aacatgattt gtgtctatga     5580

agtgctggat aattagcatg ggatgagctc tgggcatgcc atgaaggaaa gccacgctcc     5640

cttcagaatt cagaggcagg gagcaattcc agtttcacct aagtctcata attttagttc     5700

ccttttaaaa accctgaaaa ctacatcacc atggaatgaa aaatattgtt atacaataca     5760

ttgatctgtc aaacttccag aaccatggta gccttcagtg agatttccat cttggctggt     5820

cactccctga ctgtagctgt aggtgaatgt gtttttgtgt gtgtgtgtct ggttttagtg     5880

tcagaaggga aataaaagtg taaggaggac actttaaacc ctttgggtgg agtttcgtaa     5940

tttcccagac tattttcaag caacctggtc cacccaggat tagtgaccag gttttcagga     6000

aaggatttgc ttctctctag aaaatgtctg aaaggatttt attttctgat gaaaggctgt     6060

atgaaaatac cctcctcaaa taacttgctt aactacatat agattcaagt gtgtcaatat     6120

tctattttgt atattaaatg ctatataatg gggacaaatc tatattatac tgtgtatggc     6180

attattaaga agctttttca ttatttttta tcacagtaat tttaaaatgt gtaaaaatta     6240

aaaccagtga ctcctgttta aaaataaaag ttgtagtttt ttattcatgc tgaataataa     6300

tctgtagtta aaaaaaaagt gtctttttac ctacgcagtg aaatgtcaga ctgtaaaacc     6360

ttgtgtggaa atgtttaact tttatttttt catttaaatt tgctgttctg gtattaccaa     6420

accacacatt tgtaccgaat tggcagtaaa tgttagccat ttacagcaat gccaaatatg     6480

gagaaacatc ataataaaaa aatctgcttt ttcatta                              6517


<210> 17
<211> 6410
<212> DNA
<213> Homo sapiens

<400> 17
cttctctccc agtgcgagag cgcggcggcg gcagctgaag acccggccgc ccagatgatg       60

cggtggtggg ggacctgccg gcacgcgact ccccccgggc ccaaattgat attcactgat      120

ggactccaaa gaatcattaa ctcctggtag agaagaaaac cccagcagtg tgcttgctca      180

ggagagggga gatgtgatgg acttctataa aaccctaaga ggaggagcta ctgtgaaggt      240

ttctgcgtct tcaccctcac tggctgtcgc ttctcaatca gactccaagc agcgaagact      300

tttggttgat tttccaaaag gctcagtaag caatgcgcag cagccagatc tgtccaaagc      360

agtttcactc tcaatgggac tgtatatggg agagacagaa acaaaagtga tgggaaatga      420

cctgggattc ccacagcagg gccaaatcag cctttcctcg ggggaaacag acttaaagct      480

tttggaagaa agcattgcaa acctcaatag gtcgaccagt gttccagaga accccaagag      540

ttcagcatcc actgctgtgt ctgctgcccc cacagagaag gagtttccaa aaactcactc      600

tgatgtatct tcagaacagc aacatttgaa gggccagact ggcaccaacg gtggcaatgt      660

gaaattgtat accacagacc aaagcacctt tgacattttg caggatttgg agttttcttc      720

tgggtcccca ggtaaagaga cgaatgagag tccttggaga tcagacctgt tgatagatga      780

aaactgtttg ctttctcctc tggcgggaga agacgattca ttccttttgg aaggaaactc      840

gaatgaggac tgcaagcctc tcattttacc ggacactaaa cccaaaatta aggataatgg      900

agatctggtt ttgtcaagcc ccagtaatgt aacactgccc caagtgaaaa cagaaaaaga      960

agatttcatc gaactctgca cccctggggt aattaagcaa gagaaactgg gcacagttta     1020

ctgtcaggca agctttcctg gagcaaatat aattggtaat aaaatgtctg ccatttctgt     1080

tcatggtgtg agtacctctg gaggacagat gtaccactat gacatgaata cagcatccct     1140

ttctcaacag caggatcaga agcctatttt taatgtcatt ccaccaattc ccgttggttc     1200

cgaaaattgg aataggtgcc aaggatctgg agatgacaac ttgacttctc tggggactct     1260

gaacttccct ggtcgaacag ttttttctaa tggctattca agccccagca tgagaccaga     1320

tgtaagctct cctccatcca gctcctcaac agcaacaaca ggaccacctc ccaaactctg     1380

cctggtgtgc tctgatgaag cttcaggatg tcattatgga gtcttaactt gtggaagctg     1440

taaagttttc ttcaaaagag cagtggaagg acagcacaat tacctatgtg ctggaaggaa     1500

tgattgcatc atcgataaaa ttcgaagaaa aaactgccca gcatgccgct atcgaaaatg     1560

tcttcaggct ggaatgaacc tggaagctcg aaaaacaaag aaaaaaataa aaggaattca     1620

gcaggccact acaggagtct cacaagaaac ctctgaaaat cctggtaaca aaacaatagt     1680

tcctgcaacg ttaccacaac tcacccctac cctggtgtca ctgttggagg ttattgaacc     1740

tgaagtgtta tatgcaggat atgatagctc tgttccagac tcaacttgga ggatcatgac     1800

tacgctcaac atgttaggag ggcggcaagt gattgcagca gtgaaatggg caaaggcaat     1860

accaggtttc aggaacttac acctggatga ccaaatgacc ctactgcagt actcctggat     1920

gtttcttatg gcatttgctc tggggtggag atcatataga caatcaagtg caaacctgct     1980

gtgttttgct cctgatctga ttattaatga gcagagaatg actctaccct gcatgtacga     2040

ccaatgtaaa cacatgctgt atgtttcctc tgagttacac aggcttcagg tatcttatga     2100

agagtatctc tgtatgaaaa ccttactgct tctctcttca gttcctaagg acggtctgaa     2160

gagccaagag ctatttgatg aaattagaat gacctacatc aaagagctag gaaaagccat     2220

tgtcaagagg gaaggaaact ccagccagaa ctggcagcgg ttttatcaac tgacaaaact     2280

cttggattct atgcatgaag tggttgaaaa tctccttaac tattgcttcc aaacattttt     2340

ggataagacc atgagtattg aattccccga gatgttagct gaaatcatca ccaatcagat     2400

accaaaatat tcaaatggaa atatcaaaaa acttctgttt catcaaaagt gactgcctta     2460

ataagaatgg ttgccttaaa gaaagtcgaa ttaatagctt ttattgtata aactatcagt     2520

ttgtcctgta gaggttttgt tgttttattt tttattgttt tcatctgttg ttttgtttta     2580

aatacgcact acatgtggtt tatagagggc caagacttgg caacagaagc agttgagtcg     2640

tcatcacttt tcagtgatgg gagagtagat ggtgaaattt attagttaat atatcccaga     2700

aattagaaac cttaatatgt ggacgtaatc tccacagtca aagaaggatg gcacctaaac     2760

caccagtgcc caaagtctgt gtgatgaact ttctcttcat actttttttc acagttggct     2820

ggatgaaatt ttctagactt tctgttggtg tatccccccc ctgtatagtt aggatagcat     2880

ttttgattta tgcatggaaa cctgaaaaaa agtttacaag tgtatatcag aaaagggaag     2940

ttgtgccttt tatagctatt actgtctggt tttaacaatt tcctttatat ttagtgaact     3000

acgcttgctc attttttctt acataatttt ttattcaagt tattgtacag ctgtttaaga     3060

tgggcagcta gttcgtagct ttcccaaata aactctaaac attaatcaat catctgtgtg     3120

aaaatgggtt ggtgcttcta acctgatggc acttagctat cagaagacca caaaaattga     3180

ctcaaatctc cagtattctt gtcaaaaaaa aaaaaaaaaa agctcatatt ttgtatatat     3240

ctgcttcagt ggagaattat ataggttgtg caaattaaca gtcctaactg gtatagagca     3300

cctagtccag tgacctgctg ggtaaactgt ggatgatggt tgcaaaagac taatttaaaa     3360

aataactacc aagaggccct gtctgtacct aacgccctat ttttgcaatg gctatatggc     3420

aagaaagctg gtaaactatt tgtctttcag gaccttttga agtagtttgt ataacttctt     3480

aaaagttgtg attccagata accagctgta acacagctga gagactttta atcagacaaa     3540

gtaattcctc tcactaaact ttacccaaaa actaaatctc taatatggca aaaatggcta     3600

gacacccatt ttcacattcc catctgtcac caattggtta atctttcctg atggtacagg     3660

aaagctcagc tactgatttt tgtgatttag aactgtatgt cagacatcca tgtttgtaaa     3720

actacacatc cctaatgtgt gccatagagt ttaacacaag tcctgtgaat ttcttcactg     3780

ttgaaaatta ttttaaacaa aatagaagct gtagtagccc tttctgtgtg caccttacca     3840

actttctgta aactcaaaac ttaacatatt tactaagcca caagaaattt gatttctatt     3900

caaggtggcc aaattatttg tgtaatagaa aactgaaaat ctaatattaa aaatatggaa     3960

cttctaatat atttttatat ttagttatag tttcagatat atatcatatt ggtattcact     4020

aatctgggaa gggaagggct actgcagctt tacatgcaat ttattaaaat gattgtaaaa     4080

tagcttgtat agtgtaaaat aagaatgatt tttagatgag attgttttat catgacatgt     4140

tatatatttt ttgtaggggt caaagaaatg ctgatggata acctatatga tttatagttt     4200

gtacatgcat tcatacaggc agcgatggtc tcagaaacca aacagtttgc tctaggggaa     4260

gagggagatg gagactggtc ctgtgtgcag tgaaggttgc tgaggctctg acccagtgag     4320

attacagagg aagttatcct ctgcctccca ttctgaccac ccttctcatt ccaacagtga     4380

gtctgtcagc gcaggtttag tttactcaat ctccccttgc actaaagtat gtaaagtatg     4440

taaacaggag acaggaaggt ggtgcttaca tccttaaagg caccatctaa tagcgggtta     4500

ctttcacata cagccctccc ccagcagttg aatgacaaca gaagcttcag aagtttggca     4560

atagtttgca tagaggtacc agcaatatgt aaatagtgca gaatctcata ggttgccaat     4620

aatacactaa ttcctttcta tcctacaaca agagtttatt tccaaataaa atgaggacat     4680

gtttttgttt tctttgaatg ctttttgaat gttatttgtt attttcagta ttttggagaa     4740

attatttaat aaaaaaacaa tcatttgctt tttgaatgct ctctaaaagg gaatgtaata     4800

ttttaagatg gtgtgtaacc cggctggata aatttttggt gcctaagaaa actgcttgaa     4860

tattcttatc aatgacagtg ttaagtttca aaaagagctt ctaaaacgta gattatcatt     4920

cctttataga atgttatgtg gttaaaacca gaaagcacat ctcacacatt aatctgattt     4980

tcatcccaac aatcttggcg ctcaaaaaat agaactcaat gagaaaaaga agattatgtg     5040

cacttcgttg tcaataataa gtcaactgat gctcatcgac aactatagga ggcttttcat     5100

taaatgggaa aagaagctgt gcccttttag gatacgtggg ggaaaagaaa gtcatcttaa     5160

ttatgtttaa ttgtggattt aagtgctata tggtggtgct gtttgaaagc agatttattt     5220

cctatgtatg tgttatctgg ccatcccaac ccaaactgtt gaagtttgta gtaacttcag     5280

tgagagttgg ttactcacaa caaatcctga aaagtatttt tagtgtttgt aggtattctg     5340

tgggatacta tacaagcaga actgaggcac ttaggacata acacttttgg ggtatatata     5400

tccaaatgcc taaaactatg ggaggaaacc ttggccaccc caaaaggaaa actaacatga     5460

tttgtgtcta tgaagtgctg gataattagc atgggatgag ctctgggcat gccatgaagg     5520

aaagccacgc tcccttcaga attcagaggc agggagcaat tccagtttca cctaagtctc     5580

ataattttag ttccctttta aaaaccctga aaactacatc accatggaat gaaaaatatt     5640

gttatacaat acattgatct gtcaaacttc cagaaccatg gtagccttca gtgagatttc     5700

catcttggct ggtcactccc tgactgtagc tgtaggtgaa tgtgtttttg tgtgtgtgtg     5760

tctggtttta gtgtcagaag ggaaataaaa gtgtaaggag gacactttaa accctttggg     5820

tggagtttcg taatttccca gactattttc aagcaacctg gtccacccag gattagtgac     5880

caggttttca ggaaaggatt tgcttctctc tagaaaatgt ctgaaaggat tttattttct     5940

gatgaaaggc tgtatgaaaa taccctcctc aaataacttg cttaactaca tatagattca     6000

agtgtgtcaa tattctattt tgtatattaa atgctatata atggggacaa atctatatta     6060

tactgtgtat ggcattatta agaagctttt tcattatttt ttatcacagt aattttaaaa     6120

tgtgtaaaaa ttaaaaccag tgactcctgt ttaaaaataa aagttgtagt tttttattca     6180

tgctgaataa taatctgtag ttaaaaaaaa agtgtctttt tacctacgca gtgaaatgtc     6240

agactgtaaa accttgtgtg gaaatgttta acttttattt tttcatttaa atttgctgtt     6300

ctggtattac caaaccacac atttgtaccg aattggcagt aaatgttagc catttacagc     6360

aatgccaaat atggagaaac atcataataa aaaaatctgc tttttcatta                6410


<210> 18
<211> 7286
<212> DNA
<213> Homo sapiens

<400> 18
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct       60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac      120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga      180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac      240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac      300

agaaagaggg taagagaaga aaaaagggaa agtggtgaag gcagggagga aaattgctta      360

gtgtgaatat gcacgcattc atttagtttt caaatccttg ttgagcatga taaaattccc      420

agcatcagac ctcacatgtt ggtttccatt aggatctgcc tgggggaata tctgctgaat      480

cagtggctct gagctgaact aggaaattca ccataattag gagagtcact gtatttctct      540

ccaaaaaaaa aaaagttata cccgagagac aggatcttct gatctgaaat tttcttcact      600

tctgaaattc tctggtttgt gctcatcgtt ggtagctatt tgttcatcaa gagttgtgta      660

gctggcttct tctgaaaaaa ggaatctgcg tcatatctaa gtcagatttc attctggtgc      720

tctcagagca gttagcccag gaaaggggcc agcttctgtg acgactgctg cagaggcagg      780

tgcagtttgt gtgccacaga tattaacttt gataagcact taatgagtgc cttctctgtg      840

cgagaatggg gaggaacaaa atgcagctcc taccctcctc gggctttagt tgtaccttaa      900

taacaggaat tttcatctgc ctggctcctt tcctcaaaga acaaagaaga ctttgcttca      960

ttaaagtgtc tgagaaggaa gttgatattc actgatggac tccaaagaat cattaactcc     1020

tggtagagaa gaaaacccca gcagtgtgct tgctcaggag aggggagatg tgatggactt     1080

ctataaaacc ctaagaggag gagctactgt gaaggtttct gcgtcttcac cctcactggc     1140

tgtcgcttct caatcagact ccaagcagcg aagacttttg gttgattttc caaaaggctc     1200

agtaagcaat gcgcagcagc cagatctgtc caaagcagtt tcactctcaa tgggactgta     1260

tatgggagag acagaaacaa aagtgatggg aaatgacctg ggattcccac agcagggcca     1320

aatcagcctt tcctcggggg aaacagactt aaagcttttg gaagaaagca ttgcaaacct     1380

caataggtcg accagtgttc cagagaaccc caagagttca gcatccactg ctgtgtctgc     1440

tgcccccaca gagaaggagt ttccaaaaac tcactctgat gtatcttcag aacagcaaca     1500

tttgaagggc cagactggca ccaacggtgg caatgtgaaa ttgtatacca cagaccaaag     1560

cacctttgac attttgcagg atttggagtt ttcttctggg tccccaggta aagagacgaa     1620

tgagagtcct tggagatcag acctgttgat agatgaaaac tgtttgcttt ctcctctggc     1680

gggagaagac gattcattcc ttttggaagg aaactcgaat gaggactgca agcctctcat     1740

tttaccggac actaaaccca aaattaagga taatggagat ctggttttgt caagccccag     1800

taatgtaaca ctgccccaag tgaaaacaga aaaagaagat ttcatcgaac tctgcacccc     1860

tggggtaatt aagcaagaga aactgggcac agtttactgt caggcaagct ttcctggagc     1920

aaatataatt ggtaataaaa tgtctgccat ttctgttcat ggtgtgagta cctctggagg     1980

acagatgtac cactatgaca tgaatacagc atccctttct caacagcagg atcagaagcc     2040

tatttttaat gtcattccac caattcccgt tggttccgaa aattggaata ggtgccaagg     2100

atctggagat gacaacttga cttctctggg gactctgaac ttccctggtc gaacagtttt     2160

ttctaatggc tattcaagcc ccagcatgag accagatgta agctctcctc catccagctc     2220

ctcaacagca acaacaggac cacctcccaa actctgcctg gtgtgctctg atgaagcttc     2280

aggatgtcat tatggagtct taacttgtgg aagctgtaaa gttttcttca aaagagcagt     2340

ggaaggacag cacaattacc tatgtgctgg aaggaatgat tgcatcatcg ataaaattcg     2400

aagaaaaaac tgcccagcat gccgctatcg aaaatgtctt caggctggaa tgaacctgga     2460

agctcgaaaa acaaagaaaa aaataaaagg aattcagcag gccactacag gagtctcaca     2520

agaaacctct gaaaatcctg gtaacaaaac aatagttcct gcaacgttac cacaactcac     2580

ccctaccctg gtgtcactgt tggaggttat tgaacctgaa gtgttatatg caggatatga     2640

tagctctgtt ccagactcaa cttggaggat catgactacg ctcaacatgt taggagggcg     2700

gcaagtgatt gcagcagtga aatgggcaaa ggcaatacca ggtttcagga acttacacct     2760

ggatgaccaa atgaccctac tgcagtactc ctggatgttt cttatggcat ttgctctggg     2820

gtggagatca tatagacaat caagtgcaaa cctgctgtgt tttgctcctg atctgattat     2880

taatgagcag agaatgactc taccctgcat gtacgaccaa tgtaaacaca tgctgtatgt     2940

ttcctctgag ttacacaggc ttcaggtatc ttatgaagag tatctctgta tgaaaacctt     3000

actgcttctc tcttcagttc ctaaggacgg tctgaagagc caagagctat ttgatgaaat     3060

tagaatgacc tacatcaaag agctaggaaa agccattgtc aagagggaag gaaactccag     3120

ccagaactgg cagcggtttt atcaactgac aaaactcttg gattctatgc atgaagtggt     3180

tgaaaatctc cttaactatt gcttccaaac atttttggat aagaccatga gtattgaatt     3240

ccccgagatg ttagctgaaa tcatcaccaa tcagatacca aaatattcaa atggaaatat     3300

caaaaaactt ctgtttcatc aaaagtgact gccttaataa gaatggttgc cttaaagaaa     3360

gtcgaattaa tagcttttat tgtataaact atcagtttgt cctgtagagg ttttgttgtt     3420

ttatttttta ttgttttcat ctgttgtttt gttttaaata cgcactacat gtggtttata     3480

gagggccaag acttggcaac agaagcagtt gagtcgtcat cacttttcag tgatgggaga     3540

gtagatggtg aaatttatta gttaatatat cccagaaatt agaaacctta atatgtggac     3600

gtaatctcca cagtcaaaga aggatggcac ctaaaccacc agtgcccaaa gtctgtgtga     3660

tgaactttct cttcatactt tttttcacag ttggctggat gaaattttct agactttctg     3720

ttggtgtatc ccccccctgt atagttagga tagcattttt gatttatgca tggaaacctg     3780

aaaaaaagtt tacaagtgta tatcagaaaa gggaagttgt gccttttata gctattactg     3840

tctggtttta acaatttcct ttatatttag tgaactacgc ttgctcattt tttcttacat     3900

aattttttat tcaagttatt gtacagctgt ttaagatggg cagctagttc gtagctttcc     3960

caaataaact ctaaacatta atcaatcatc tgtgtgaaaa tgggttggtg cttctaacct     4020

gatggcactt agctatcaga agaccacaaa aattgactca aatctccagt attcttgtca     4080

aaaaaaaaaa aaaaaaagct catattttgt atatatctgc ttcagtggag aattatatag     4140

gttgtgcaaa ttaacagtcc taactggtat agagcaccta gtccagtgac ctgctgggta     4200

aactgtggat gatggttgca aaagactaat ttaaaaaata actaccaaga ggccctgtct     4260

gtacctaacg ccctattttt gcaatggcta tatggcaaga aagctggtaa actatttgtc     4320

tttcaggacc ttttgaagta gtttgtataa cttcttaaaa gttgtgattc cagataacca     4380

gctgtaacac agctgagaga cttttaatca gacaaagtaa ttcctctcac taaactttac     4440

ccaaaaacta aatctctaat atggcaaaaa tggctagaca cccattttca cattcccatc     4500

tgtcaccaat tggttaatct ttcctgatgg tacaggaaag ctcagctact gatttttgtg     4560

atttagaact gtatgtcaga catccatgtt tgtaaaacta cacatcccta atgtgtgcca     4620

tagagtttaa cacaagtcct gtgaatttct tcactgttga aaattatttt aaacaaaata     4680

gaagctgtag tagccctttc tgtgtgcacc ttaccaactt tctgtaaact caaaacttaa     4740

catatttact aagccacaag aaatttgatt tctattcaag gtggccaaat tatttgtgta     4800

atagaaaact gaaaatctaa tattaaaaat atggaacttc taatatattt ttatatttag     4860

ttatagtttc agatatatat catattggta ttcactaatc tgggaaggga agggctactg     4920

cagctttaca tgcaatttat taaaatgatt gtaaaatagc ttgtatagtg taaaataaga     4980

atgattttta gatgagattg ttttatcatg acatgttata tattttttgt aggggtcaaa     5040

gaaatgctga tggataacct atatgattta tagtttgtac atgcattcat acaggcagcg     5100

atggtctcag aaaccaaaca gtttgctcta ggggaagagg gagatggaga ctggtcctgt     5160

gtgcagtgaa ggttgctgag gctctgaccc agtgagatta cagaggaagt tatcctctgc     5220

ctcccattct gaccaccctt ctcattccaa cagtgagtct gtcagcgcag gtttagttta     5280

ctcaatctcc ccttgcacta aagtatgtaa agtatgtaaa caggagacag gaaggtggtg     5340

cttacatcct taaaggcacc atctaatagc gggttacttt cacatacagc cctcccccag     5400

cagttgaatg acaacagaag cttcagaagt ttggcaatag tttgcataga ggtaccagca     5460

atatgtaaat agtgcagaat ctcataggtt gccaataata cactaattcc tttctatcct     5520

acaacaagag tttatttcca aataaaatga ggacatgttt ttgttttctt tgaatgcttt     5580

ttgaatgtta tttgttattt tcagtatttt ggagaaatta tttaataaaa aaacaatcat     5640

ttgctttttg aatgctctct aaaagggaat gtaatatttt aagatggtgt gtaacccggc     5700

tggataaatt tttggtgcct aagaaaactg cttgaatatt cttatcaatg acagtgttaa     5760

gtttcaaaaa gagcttctaa aacgtagatt atcattcctt tatagaatgt tatgtggtta     5820

aaaccagaaa gcacatctca cacattaatc tgattttcat cccaacaatc ttggcgctca     5880

aaaaatagaa ctcaatgaga aaaagaagat tatgtgcact tcgttgtcaa taataagtca     5940

actgatgctc atcgacaact ataggaggct tttcattaaa tgggaaaaga agctgtgccc     6000

ttttaggata cgtgggggaa aagaaagtca tcttaattat gtttaattgt ggatttaagt     6060

gctatatggt ggtgctgttt gaaagcagat ttatttccta tgtatgtgtt atctggccat     6120

cccaacccaa actgttgaag tttgtagtaa cttcagtgag agttggttac tcacaacaaa     6180

tcctgaaaag tatttttagt gtttgtaggt attctgtggg atactataca agcagaactg     6240

aggcacttag gacataacac ttttggggta tatatatcca aatgcctaaa actatgggag     6300

gaaaccttgg ccaccccaaa aggaaaacta acatgatttg tgtctatgaa gtgctggata     6360

attagcatgg gatgagctct gggcatgcca tgaaggaaag ccacgctccc ttcagaattc     6420

agaggcaggg agcaattcca gtttcaccta agtctcataa ttttagttcc cttttaaaaa     6480

ccctgaaaac tacatcacca tggaatgaaa aatattgtta tacaatacat tgatctgtca     6540

aacttccaga accatggtag ccttcagtga gatttccatc ttggctggtc actccctgac     6600

tgtagctgta ggtgaatgtg tttttgtgtg tgtgtgtctg gttttagtgt cagaagggaa     6660

ataaaagtgt aaggaggaca ctttaaaccc tttgggtgga gtttcgtaat ttcccagact     6720

attttcaagc aacctggtcc acccaggatt agtgaccagg ttttcaggaa aggatttgct     6780

tctctctaga aaatgtctga aaggatttta ttttctgatg aaaggctgta tgaaaatacc     6840

ctcctcaaat aacttgctta actacatata gattcaagtg tgtcaatatt ctattttgta     6900

tattaaatgc tatataatgg ggacaaatct atattatact gtgtatggca ttattaagaa     6960

gctttttcat tattttttat cacagtaatt ttaaaatgtg taaaaattaa aaccagtgac     7020

tcctgtttaa aaataaaagt tgtagttttt tattcatgct gaataataat ctgtagttaa     7080

aaaaaaagtg tctttttacc tacgcagtga aatgtcagac tgtaaaacct tgtgtggaaa     7140

tgtttaactt ttattttttc atttaaattt gctgttctgg tattaccaaa ccacacattt     7200

gtaccgaatt ggcagtaaat gttagccatt tacagcaatg ccaaatatgg agaaacatca     7260

taataaaaaa atctgctttt tcatta                                          7286


<210> 19
<211> 4154
<212> DNA
<213> Homo sapiens

<400> 19
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct       60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc      120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag      180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac      240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga      300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt      360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt      420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt      480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc      540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga      600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc      660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca      720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa      780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa      840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca      900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt      960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc     1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat     1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac     1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt     1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa     1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg     1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa     1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg     1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg     1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca     1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact     1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc     1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca     1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta     1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta     1860

tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc     1920

cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa     1980

ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt     2040

aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg     2100

gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact     2160

tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa     2220

tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg     2280

cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca     2340

agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta     2400

ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt     2460

caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct     2520

aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag     2580

ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat     2640

caactgacaa aactcttgga ttctatgcat gaaaatgtta tgtggttaaa accagaaagc     2700

acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact     2760

caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat     2820

cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg     2880

tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg     2940

tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac     3000

tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta     3060

tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga     3120

cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc     3180

accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga     3240

tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag     3300

caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta     3360

catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac     3420

catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg     3480

tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa     3540

ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa     3600

cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa     3660

atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa     3720

cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta     3780

tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta     3840

ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa     3900

ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc     3960

tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt     4020

attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg     4080

cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat     4140

ctgctttttc atta                                                       4154


<210> 20
<211> 6787
<212> DNA
<213> Homo sapiens

<400> 20
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct       60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc      120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag      180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac      240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga      300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt      360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt      420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt      480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc      540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga      600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc      660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca      720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa      780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa      840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca      900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt      960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc     1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat     1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac     1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt     1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa     1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg     1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa     1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg     1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg     1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca     1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact     1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc     1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca     1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta     1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggtagaca gcacaattac     1860

ctatgtgctg gaaggaatga ttgcatcatc gataaaattc gaagaaaaaa ctgcccagca     1920

tgccgctatc gaaaatgtct tcaggctgga atgaacctgg aagctcgaaa aacaaagaaa     1980

aaaataaaag gaattcagca ggccactaca ggagtctcac aagaaacctc tgaaaatcct     2040

ggtaacaaaa caatagttcc tgcaacgtta ccacaactca cccctaccct ggtgtcactg     2100

ttggaggtta ttgaacctga agtgttatat gcaggatatg atagctctgt tccagactca     2160

acttggagga tcatgactac gctcaacatg ttaggagggc ggcaagtgat tgcagcagtg     2220

aaatgggcaa aggcaatacc aggtttcagg aacttacacc tggatgacca aatgacccta     2280

ctgcagtact cctggatgtt tcttatggca tttgctctgg ggtggagatc atatagacaa     2340

tcaagtgcaa acctgctgtg ttttgctcct gatctgatta ttaatgagca gagaatgact     2400

ctaccctgca tgtacgacca atgtaaacac atgctgtatg tttcctctga gttacacagg     2460

cttcaggtat cttatgaaga gtatctctgt atgaaaacct tactgcttct ctcttcagtt     2520

cctaaggacg gtctgaagag ccaagagcta tttgatgaaa ttagaatgac ctacatcaaa     2580

gagctaggaa aagccattgt caagagggaa ggaaactcca gccagaactg gcagcggttt     2640

tatcaactga caaaactctt ggattctatg catgaagtgg ttgaaaatct ccttaactat     2700

tgcttccaaa catttttgga taagaccatg agtattgaat tccccgagat gttagctgaa     2760

atcatcacca atcagatacc aaaatattca aatggaaata tcaaaaaact tctgtttcat     2820

caaaagtgac tgccttaata agaatggttg ccttaaagaa agtcgaatta atagctttta     2880

ttgtataaac tatcagtttg tcctgtagag gttttgttgt tttatttttt attgttttca     2940

tctgttgttt tgttttaaat acgcactaca tgtggtttat agagggccaa gacttggcaa     3000

cagaagcagt tgagtcgtca tcacttttca gtgatgggag agtagatggt gaaatttatt     3060

agttaatata tcccagaaat tagaaacctt aatatgtgga cgtaatctcc acagtcaaag     3120

aaggatggca cctaaaccac cagtgcccaa agtctgtgtg atgaactttc tcttcatact     3180

ttttttcaca gttggctgga tgaaattttc tagactttct gttggtgtat cccccccctg     3240

tatagttagg atagcatttt tgatttatgc atggaaacct gaaaaaaagt ttacaagtgt     3300

atatcagaaa agggaagttg tgccttttat agctattact gtctggtttt aacaatttcc     3360

tttatattta gtgaactacg cttgctcatt ttttcttaca taatttttta ttcaagttat     3420

tgtacagctg tttaagatgg gcagctagtt cgtagctttc ccaaataaac tctaaacatt     3480

aatcaatcat ctgtgtgaaa atgggttggt gcttctaacc tgatggcact tagctatcag     3540

aagaccacaa aaattgactc aaatctccag tattcttgtc aaaaaaaaaa aaaaaaaagc     3600

tcatattttg tatatatctg cttcagtgga gaattatata ggttgtgcaa attaacagtc     3660

ctaactggta tagagcacct agtccagtga cctgctgggt aaactgtgga tgatggttgc     3720

aaaagactaa tttaaaaaat aactaccaag aggccctgtc tgtacctaac gccctatttt     3780

tgcaatggct atatggcaag aaagctggta aactatttgt ctttcaggac cttttgaagt     3840

agtttgtata acttcttaaa agttgtgatt ccagataacc agctgtaaca cagctgagag     3900

acttttaatc agacaaagta attcctctca ctaaacttta cccaaaaact aaatctctaa     3960

tatggcaaaa atggctagac acccattttc acattcccat ctgtcaccaa ttggttaatc     4020

tttcctgatg gtacaggaaa gctcagctac tgatttttgt gatttagaac tgtatgtcag     4080

acatccatgt ttgtaaaact acacatccct aatgtgtgcc atagagttta acacaagtcc     4140

tgtgaatttc ttcactgttg aaaattattt taaacaaaat agaagctgta gtagcccttt     4200

ctgtgtgcac cttaccaact ttctgtaaac tcaaaactta acatatttac taagccacaa     4260

gaaatttgat ttctattcaa ggtggccaaa ttatttgtgt aatagaaaac tgaaaatcta     4320

atattaaaaa tatggaactt ctaatatatt tttatattta gttatagttt cagatatata     4380

tcatattggt attcactaat ctgggaaggg aagggctact gcagctttac atgcaattta     4440

ttaaaatgat tgtaaaatag cttgtatagt gtaaaataag aatgattttt agatgagatt     4500

gttttatcat gacatgttat atattttttg taggggtcaa agaaatgctg atggataacc     4560

tatatgattt atagtttgta catgcattca tacaggcagc gatggtctca gaaaccaaac     4620

agtttgctct aggggaagag ggagatggag actggtcctg tgtgcagtga aggttgctga     4680

ggctctgacc cagtgagatt acagaggaag ttatcctctg cctcccattc tgaccaccct     4740

tctcattcca acagtgagtc tgtcagcgca ggtttagttt actcaatctc cccttgcact     4800

aaagtatgta aagtatgtaa acaggagaca ggaaggtggt gcttacatcc ttaaaggcac     4860

catctaatag cgggttactt tcacatacag ccctccccca gcagttgaat gacaacagaa     4920

gcttcagaag tttggcaata gtttgcatag aggtaccagc aatatgtaaa tagtgcagaa     4980

tctcataggt tgccaataat acactaattc ctttctatcc tacaacaaga gtttatttcc     5040

aaataaaatg aggacatgtt tttgttttct ttgaatgctt tttgaatgtt atttgttatt     5100

ttcagtattt tggagaaatt atttaataaa aaaacaatca tttgcttttt gaatgctctc     5160

taaaagggaa tgtaatattt taagatggtg tgtaacccgg ctggataaat ttttggtgcc     5220

taagaaaact gcttgaatat tcttatcaat gacagtgtta agtttcaaaa agagcttcta     5280

aaacgtagat tatcattcct ttatagaatg ttatgtggtt aaaaccagaa agcacatctc     5340

acacattaat ctgattttca tcccaacaat cttggcgctc aaaaaataga actcaatgag     5400

aaaaagaaga ttatgtgcac ttcgttgtca ataataagtc aactgatgct catcgacaac     5460

tataggaggc ttttcattaa atgggaaaag aagctgtgcc cttttaggat acgtggggga     5520

aaagaaagtc atcttaatta tgtttaattg tggatttaag tgctatatgg tggtgctgtt     5580

tgaaagcaga tttatttcct atgtatgtgt tatctggcca tcccaaccca aactgttgaa     5640

gtttgtagta acttcagtga gagttggtta ctcacaacaa atcctgaaaa gtatttttag     5700

tgtttgtagg tattctgtgg gatactatac aagcagaact gaggcactta ggacataaca     5760

cttttggggt atatatatcc aaatgcctaa aactatggga ggaaaccttg gccaccccaa     5820

aaggaaaact aacatgattt gtgtctatga agtgctggat aattagcatg ggatgagctc     5880

tgggcatgcc atgaaggaaa gccacgctcc cttcagaatt cagaggcagg gagcaattcc     5940

agtttcacct aagtctcata attttagttc ccttttaaaa accctgaaaa ctacatcacc     6000

atggaatgaa aaatattgtt atacaataca ttgatctgtc aaacttccag aaccatggta     6060

gccttcagtg agatttccat cttggctggt cactccctga ctgtagctgt aggtgaatgt     6120

gtttttgtgt gtgtgtgtct ggttttagtg tcagaaggga aataaaagtg taaggaggac     6180

actttaaacc ctttgggtgg agtttcgtaa tttcccagac tattttcaag caacctggtc     6240

cacccaggat tagtgaccag gttttcagga aaggatttgc ttctctctag aaaatgtctg     6300

aaaggatttt attttctgat gaaaggctgt atgaaaatac cctcctcaaa taacttgctt     6360

aactacatat agattcaagt gtgtcaatat tctattttgt atattaaatg ctatataatg     6420

gggacaaatc tatattatac tgtgtatggc attattaaga agctttttca ttatttttta     6480

tcacagtaat tttaaaatgt gtaaaaatta aaaccagtga ctcctgttta aaaataaaag     6540

ttgtagtttt ttattcatgc tgaataataa tctgtagtta aaaaaaaagt gtctttttac     6600

ctacgcagtg aaatgtcaga ctgtaaaacc ttgtgtggaa atgtttaact tttatttttt     6660

catttaaatt tgctgttctg gtattaccaa accacacatt tgtaccgaat tggcagtaaa     6720

tgttagccat ttacagcaat gccaaatatg gagaaacatc ataataaaaa aatctgcttt     6780

ttcatta                                                               6787


<210> 21
<211> 4104
<212> DNA
<213> Homo sapiens

<400> 21
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct       60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc      120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag      180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac      240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga      300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt      360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt      420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt      480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc      540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga      600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc      660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca      720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa      780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa      840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca      900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt      960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc     1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat     1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac     1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt     1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa     1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg     1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa     1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg     1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg     1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca     1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact     1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc     1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca     1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta     1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta     1860

tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc     1920

cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa     1980

ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt     2040

aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg     2100

gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact     2160

tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa     2220

tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg     2280

cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca     2340

agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta     2400

ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt     2460

caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcaggttgg     2520

tagaacacct tttcacctta tgtcaaaagc atgaaatatg aaggcctaga aacaaaggtt     2580

aatttatata catagtacta ataattatac caagtctact attatttcct actagtcaga     2640

tgatttttat gaatgtaaaa tattagaaag gcacagtaag tgacaccaag attaataaga     2700

caaataggta tggcagaaac agagaggtat atgagctgca tagggatctc tgttgataag     2760

aatctgtgta gacttttttc tccttccttc ctttgatctt tgatcatggg aagacatgga     2820

aaaagaaagc taactacagt gattttgtcc actacactgt tatttggtta aaaattttag     2880

tttcctaatg agtattagca tgtatgagaa attatgggag aaaaaggcgc atcctagaaa     2940

aggtgtgctt aattactatt ggggattggt taacatagca tgggagctgg attgtcagag     3000

attcattatc tagaaaatgg caacaagagt ttataaaacg aacttctgtg agattacttt     3060

ttagctagca aagacaaaga tgtccttcag taggtgaagt gataaactat gatacatcca     3120

gatgatggaa tactattgag gactaaaaag aaataagctg tcaagccatg aaaacacatg     3180

gagggacgtt aaatgcatat tactaagtga aaaaagctaa tctgaaaggg ctacatactg     3240

tgtgattcta actatataac attccataaa aggcaaaact gtgaagacag caaaaaaaaa     3300

tcagcggttg ccagggttta gaaggaaggg agggataaat gtgcagagca cagaggattt     3360

ttagggcagt gaaaatactt cgtatgatac tacaatggtg gaaacatgtc attatacatt     3420

tatccaaacc caaagaatgt ccaccaccaa gagtgaaccc tcaactatgg actttgggtg     3480

atgatgtgtg ggacaggagg tatatgaaaa atctctgtac cttcctccca attttgctgt     3540

gaacttaaaa ctgctctaaa aaaagtcttt tttaaaaaaa gctctatgaa ctagttggta     3600

ttataaacct taggccattt caagtaaaaa ttacatatca atgtttatta aatactgagt     3660

taatagctga atacctcttt catatacaaa taagtacatt tgcaattttt taaaaagtct     3720

taattccatt agtaactgtg gtttcatagt tgccaaataa ctgtaagcta tggatgttgc     3780

acaagactgt gattttattt aatcatttca tatctattta aacatttcca aagcgcacat     3840

tcatcttaat gttttcacac tatttttgct caacaaaaag ttattttatg ttaatggata     3900

taagaagtat taataatatt tcagtcaagg caagagaacc cgataaagat cattgctaga     3960

gacgtttaat gttacctgta gcggtacact tgttaaagaa gtgattaagc agttacataa     4020

aattctgatc atagctttga ttgataccat gaaggtataa ttcagtgcct ggatactaac     4080

aactttactt gtttaaaaaa aaaa                                            4104


<210> 22
<211> 431
<212> PRT
<213> Homo sapiens

<400> 22
Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15      


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30          


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45              


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60                  


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80  


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95      


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110         


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125             


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140                 


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160 


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175     


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190         


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205             


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220                 


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240 


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255     


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270         


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285             


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300                 


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335     


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His 
            340                 345                 350         


Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile 
        355                 360                 365             


Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His 
    370                 375                 380                 


Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys 
385                 390                 395                 400 


Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu 
                405                 410                 415     


Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            420                 425                 430     


<210> 23
<211> 526
<212> PRT
<213> Homo sapiens

<400> 23
Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15      


Phe Gln Phe Phe Lys Lys Arg Val Arg Arg Trp Ile Lys Ser Pro Met 
            20                  25                  30          


Val Ser Val Asp Lys His Gln Ser Pro Ser Leu Lys Tyr Thr Gly Ser 
        35                  40                  45              


Ser Met Val His Ile Pro Pro Gly Glu Pro Asp Phe Glu Ser Ser Leu 
    50                  55                  60                  


Cys Gln Thr Cys Leu Gly Glu His Ala Phe Gln Arg Gly Val Leu Pro 
65                  70                  75                  80  


Gln Glu Asn Glu Ser Cys Ser Trp Glu Thr Gln Ser Gly Cys Glu Val 
                85                  90                  95      


Arg Glu Pro Cys Asn His Ala Asn Ile Leu Thr Lys Pro Asp Pro Arg 
            100                 105                 110         


Thr Phe Trp Thr Asn Asp Asp Pro Ala Phe Met Lys Gln Arg Arg Met 
        115                 120                 125             


Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys 
    130                 135                 140                 


Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu 
145                 150                 155                 160 


Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln 
                165                 170                 175     


Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp 
            180                 185                 190         


Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu 
        195                 200                 205             


Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu 
    210                 215                 220                 


Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser 
225                 230                 235                 240 


Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly 
                245                 250                 255     


Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp 
            260                 265                 270         


Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys 
        275                 280                 285             


Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala 
    290                 295                 300                 


Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe 
                325                 330                 335     


Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe 
            340                 345                 350         


Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro 
        355                 360                 365             


Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu 
    370                 375                 380                 


Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met 
385                 390                 395                 400 


Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr 
                405                 410                 415     


Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr 
            420                 425                 430         


Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val 
        435                 440                 445             


Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr 
    450                 455                 460                 


Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe 
465                 470                 475                 480 


Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser 
                485                 490                 495     


Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala 
            500                 505                 510         


Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
        515                 520                 525     


<210> 24
<211> 459
<212> PRT
<213> Homo sapiens

<400> 24
Met Ser Ser Gln Ser Ser Ser Leu Ser Glu Ala Cys Ser Arg Glu Ala 
1               5                   10                  15      


Tyr Ser Ser His Asn Trp Ala Leu Pro Pro Ala Ser Arg Ser Asn Pro 
            20                  25                  30          


Gln Pro Ala Tyr Pro Trp Ala Thr Arg Arg Met Lys Glu Glu Ala Ile 
        35                  40                  45              


Lys Pro Pro Leu Lys Ala Phe Met Lys Gln Arg Arg Met Gly Leu Asn 
    50                  55                  60                  


Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys His Pro 
65                  70                  75                  80  


Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro Glu Leu 
                85                  90                  95      


Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln Ile Asn 
            100                 105                 110         


Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe His Phe 
        115                 120                 125             


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Arg 
    130                 135                 140                 


His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln Lys Lys 
145                 150                 155                 160 


Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser Glu Arg Asn 
                165                 170                 175     


Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly Leu His Phe 
            180                 185                 190         


Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp Tyr Ile Asn 
        195                 200                 205             


Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys Phe Leu Glu 
    210                 215                 220                 


Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala Leu Gly Tyr 
225                 230                 235                 240 


Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
                245                 250                 255     


Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe Gly Leu Cys 
            260                 265                 270         


Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe Cys Gly Thr 
        275                 280                 285             


Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro Tyr Asp Arg 
    290                 295                 300                 


Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu Met Leu Tyr 
305                 310                 315                 320 


Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met Tyr Asp Asn 
                325                 330                 335     


Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr Asn Ser Ala 
            340                 345                 350         


Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr Lys Arg Leu 
        355                 360                 365             


Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val Phe Phe Ser 
    370                 375                 380                 


Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr Pro Pro Phe 
385                 390                 395                 400 


Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe Asp Pro Glu 
                405                 410                 415     


Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser Pro Asp Ser 
            420                 425                 430         


Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala Phe Leu Gly 
        435                 440                 445             


Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
    450                 455                 


<210> 25
<211> 445
<212> PRT
<213> Homo sapiens

<400> 25
Met Gly Glu Met Gln Gly Ala Leu Ala Arg Ala Arg Leu Glu Ser Leu 
1               5                   10                  15      


Leu Arg Pro Arg His Lys Lys Arg Ala Glu Ala Gln Lys Arg Ser Glu 
            20                  25                  30          


Ser Phe Leu Leu Ser Gly Leu Ala Phe Met Lys Gln Arg Arg Met Gly 
        35                  40                  45              


Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys 
    50                  55                  60                  


His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro 
65                  70                  75                  80  


Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln 
                85                  90                  95      


Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe 
            100                 105                 110         


His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu 
        115                 120                 125             


Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln 
    130                 135                 140                 


Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser Glu 
145                 150                 155                 160 


Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly Leu 
                165                 170                 175     


His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp Tyr 
            180                 185                 190         


Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys Phe 
        195                 200                 205             


Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala Leu 
    210                 215                 220                 


Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro Glu 
225                 230                 235                 240 


Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe Gly 
                245                 250                 255     


Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe Cys 
            260                 265                 270         


Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro Tyr 
        275                 280                 285             


Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu Met 
    290                 295                 300                 


Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met Tyr 
305                 310                 315                 320 


Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr Asn 
                325                 330                 335     


Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr Lys 
            340                 345                 350         


Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val Phe 
        355                 360                 365             


Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr Pro 
    370                 375                 380                 


Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe Asp 
385                 390                 395                 400 


Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser Pro 
                405                 410                 415     


Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala Phe 
            420                 425                 430         


Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
        435                 440                 445 


<210> 26
<211> 2414
<212> DNA
<213> Homo sapiens

<400> 26
ttttttataa ggccgagcgc gcggcctggc gcagcatacg ccgagccggt ctttgagcgc       60

taacgtcttt ctgtctcccc gcggtggtga tgacggtgaa aactgaggct gctaagggca      120

ccctcactta ctccaggatg aggggcatgg tggcaattct catcgctttc atgaagcaga      180

ggaggatggg tctgaacgac tttattcaga agattgccaa taactcctat gcatgcaaac      240

accctgaagt tcagtccatc ttgaagatct cccaacctca ggagcctgag cttatgaatg      300

ccaacccttc tcctccacca agtccttctc agcaaatcaa ccttggcccg tcgtccaatc      360

ctcatgctaa accatctgac tttcacttct tgaaagtgat cggaaagggc agttttggaa      420

aggttcttct agcaagacac aaggcagaag aagtgttcta tgcagtcaaa gttttacaga      480

agaaagcaat cctgaaaaag aaagaggaga agcatattat gtcggagcgg aatgttctgt      540

tgaagaatgt gaagcaccct ttcctggtgg gccttcactt ctctttccag actgctgaca      600

aattgtactt tgtcctagac tacattaatg gtggagagtt gttctaccat ctccagaggg      660

aacgctgctt cctggaacca cgggctcgtt tctatgctgc tgaaatagcc agtgccttgg      720

gctacctgca ttcactgaac atcgtttata gagacttaaa accagagaat attttgctag      780

attcacaggg acacattgtc cttactgact tcggactctg caaggagaac attgaacaca      840

acagcacaac atccaccttc tgtggcacgc cggagtatct cgcacctgag gtgcttcata      900

agcagcctta tgacaggact gtggactggt ggtgcctggg agctgtcttg tatgagatgc      960

tgtatggcct gccgcctttt tatagccgaa acacagctga aatgtacgac aacattctga     1020

acaagcctct ccagctgaaa ccaaatatta caaattccgc aagacacctc ctggagggcc     1080

tcctgcagaa ggacaggaca aagcggctcg gggccaagga tgacttcatg gagattaaga     1140

gtcatgtctt cttctcctta attaactggg atgatctcat taataagaag attactcccc     1200

cttttaaccc aaatgtgagt gggcccaacg acctacggca ctttgacccc gagtttaccg     1260

aagagcctgt ccccaactcc attggcaagt cccctgacag cgtcctcgtc acagccagcg     1320

tcaaggaagc tgccgaggct ttcctaggct tttcctatgc gcctcccacg gactctttcc     1380

tctgaaccct gttagggctt ggttttaaag gattttatgt gtgtttccga atgttttagt     1440

tagccttttg gtggagccgc cagctgacag gacatcttac aagagaattt gcacatctct     1500

ggaagcttag caatcttatt gcacactgtt cgctggaagc tttttgaaga gcacattctc     1560

ctcagtgagc tcatgaggtt ttcattttta ttcttccttc caacgtggtg ctatctctga     1620

aacgagcgtt agagtgccgc cttagacgga ggcaggagtt tcgttagaaa gcggacgctg     1680

ttctaaaaaa ggtctcctgc agatctgtct gggctgtgat gacgaatatt atgaaatgtg     1740

ccttttctga agagattgtg ttagctccaa agcttttcct atcgcagtgt ttcagttctt     1800

tattttccct tgtggatatg ctgtgtgaac cgtcgtgtga gtgtggtatg cctgatcaca     1860

gatggatttt gttataagca tcaatgtgac acttgcagga cactacaacg tgggacattg     1920

tttgtttctt ccatatttgg aagataaatt tatgtgtaga cttttttgta agatacggtt     1980

aataactaaa atttattgaa atggtcttgc aatgactcgt attcagatgc ttaaagaaag     2040

cattgctgct acaaatattt ctatttttag aaagggtttt tatggaccaa tgccccagtt     2100

gtcagtcaga gccgttggtg tttttcattg tttaaaatgt cacctgtaaa atgggcatta     2160

tttatgtttt tttttttgca ttcctgataa ttgtatgtat tgtataaaga acgtctgtac     2220

attgggttat aacactagta tatttaaact tacaggctta tttgtaatgt aaaccaccat     2280

tttaatgtac tgtaattaac atggttataa tacgtacaat ccttccctca tcccatcaca     2340

caactttttt tgtgtgtgat aaactgattt tggtttgcaa taaaaccttg aaaaatattt     2400

acatataaaa aaaa                                                       2414


<210> 27
<211> 3208
<212> DNA
<213> Homo sapiens

<400> 27
agatattcat gaaccgttgc ttcttccagc ctcgccttct cgctccctct gcctttctgg       60

cgctgttctc cctccctccc tctggcttct gctctttctt actccttctc tcagctgctt      120

aactacagct cccactggaa cttgcacaat caaaaacaac tctcctctct caagccgcct      180

ccaggagcgc atcacctgga gaagagcgac tcgctccccg cgccggccgc ggaagagcag      240

ccaggtagct gggggcgggg aggcgtaccc ttctcccgct cggtaagagc cacagcatct      300

ccccggagat tggccgtatc ccaccgtccg gcccccaggg tcctgcagcg gtgatgcata      360

tgtttcggag caatgatgga aggagaaaag ccgctgtcgg tggcaactga aagtggggag      420

aggttgctgc agtagctggt gctgcagaat gcgcgagtga agaactgagc cccgctagat      480

tctccatccc gctcagtctt cattaactgt ctgcaggagg taaaccgggg aaacagatat      540

gcactaacca ggcgggtgcc aacctggatc tataactgtg aattccccac ggtggaaaat      600

ggtaaacaaa gacatgaatg gattcccagt caagaaatgc tcagccttcc aattttttaa      660

gaagcgggta cgaaggtgga tcaagagccc aatggtcagt gtggacaagc atcagagtcc      720

cagcctgaag tacaccggct cctccatggt gcacatccct ccaggggagc cagacttcga      780

gtcttccttg tgtcaaacat gcctgggtga acatgctttc caaagagggg ttctccctca      840

ggagaacgag tcatgttcat gggaaactca atctgggtgt gaagtgagag agccatgtaa      900

tcatgccaac atcctgacca agcccgatcc aagaaccttc tggactaatg atgatccagc      960

tttcatgaag cagaggagga tgggtctgaa cgactttatt cagaagattg ccaataactc     1020

ctatgcatgc aaacaccctg aagttcagtc catcttgaag atctcccaac ctcaggagcc     1080

tgagcttatg aatgccaacc cttctcctcc accaagtcct tctcagcaaa tcaaccttgg     1140

cccgtcgtcc aatcctcatg ctaaaccatc tgactttcac ttcttgaaag tgatcggaaa     1200

gggcagtttt ggaaaggttc ttctagcaag acacaaggca gaagaagtgt tctatgcagt     1260

caaagtttta cagaagaaag caatcctgaa aaagaaagag gagaagcata ttatgtcgga     1320

gcggaatgtt ctgttgaaga atgtgaagca ccctttcctg gtgggccttc acttctcttt     1380

ccagactgct gacaaattgt actttgtcct agactacatt aatggtggag agttgttcta     1440

ccatctccag agggaacgct gcttcctgga accacgggct cgtttctatg ctgctgaaat     1500

agccagtgcc ttgggctacc tgcattcact gaacatcgtt tatagagact taaaaccaga     1560

gaatattttg ctagattcac agggacacat tgtccttact gacttcggac tctgcaagga     1620

gaacattgaa cacaacagca caacatccac cttctgtggc acgccggagt atctcgcacc     1680

tgaggtgctt cataagcagc cttatgacag gactgtggac tggtggtgcc tgggagctgt     1740

cttgtatgag atgctgtatg gcctgccgcc tttttatagc cgaaacacag ctgaaatgta     1800

cgacaacatt ctgaacaagc ctctccagct gaaaccaaat attacaaatt ccgcaagaca     1860

cctcctggag ggcctcctgc agaaggacag gacaaagcgg ctcggggcca aggatgactt     1920

catggagatt aagagtcatg tcttcttctc cttaattaac tgggatgatc tcattaataa     1980

gaagattact ccccctttta acccaaatgt gagtgggccc aacgacctac ggcactttga     2040

ccccgagttt accgaagagc ctgtccccaa ctccattggc aagtcccctg acagcgtcct     2100

cgtcacagcc agcgtcaagg aagctgccga ggctttccta ggcttttcct atgcgcctcc     2160

cacggactct ttcctctgaa ccctgttagg gcttggtttt aaaggatttt atgtgtgttt     2220

ccgaatgttt tagttagcct tttggtggag ccgccagctg acaggacatc ttacaagaga     2280

atttgcacat ctctggaagc ttagcaatct tattgcacac tgttcgctgg aagctttttg     2340

aagagcacat tctcctcagt gagctcatga ggttttcatt tttattcttc cttccaacgt     2400

ggtgctatct ctgaaacgag cgttagagtg ccgccttaga cggaggcagg agtttcgtta     2460

gaaagcggac gctgttctaa aaaaggtctc ctgcagatct gtctgggctg tgatgacgaa     2520

tattatgaaa tgtgcctttt ctgaagagat tgtgttagct ccaaagcttt tcctatcgca     2580

gtgtttcagt tctttatttt cccttgtgga tatgctgtgt gaaccgtcgt gtgagtgtgg     2640

tatgcctgat cacagatgga ttttgttata agcatcaatg tgacacttgc aggacactac     2700

aacgtgggac attgtttgtt tcttccatat ttggaagata aatttatgtg tagacttttt     2760

tgtaagatac ggttaataac taaaatttat tgaaatggtc ttgcaatgac tcgtattcag     2820

atgcttaaag aaagcattgc tgctacaaat atttctattt ttagaaaggg tttttatgga     2880

ccaatgcccc agttgtcagt cagagccgtt ggtgtttttc attgtttaaa atgtcacctg     2940

taaaatgggc attatttatg tttttttttt tgcattcctg ataattgtat gtattgtata     3000

aagaacgtct gtacattggg ttataacact agtatattta aacttacagg cttatttgta     3060

atgtaaacca ccattttaat gtactgtaat taacatggtt ataatacgta caatccttcc     3120

ctcatcccat cacacaactt tttttgtgtg tgataaactg attttggttt gcaataaaac     3180

cttgaaaaat atttacatat aaaaaaaa                                        3208


<210> 28
<211> 2459
<212> DNA
<213> Homo sapiens

<400> 28
aagtggggtt cataacagaa cagggatagc cgtctctggc tcgtgctctc atgtcatctc       60

agagttccag cttatcagag gcatgtagca gggaggctta ttccagccat aactgggctc      120

tacctccagc ctccagaagt aatccccaac ctgcatatcc ttgggcaacc cgaagaatga      180

aagaagaagc tataaaaccc cctttgaaag ctttcatgaa gcagaggagg atgggtctga      240

acgactttat tcagaagatt gccaataact cctatgcatg caaacaccct gaagttcagt      300

ccatcttgaa gatctcccaa cctcaggagc ctgagcttat gaatgccaac ccttctcctc      360

caccaagtcc ttctcagcaa atcaaccttg gcccgtcgtc caatcctcat gctaaaccat      420

ctgactttca cttcttgaaa gtgatcggaa agggcagttt tggaaaggtt cttctagcaa      480

gacacaaggc agaagaagtg ttctatgcag tcaaagtttt acagaagaaa gcaatcctga      540

aaaagaaaga ggagaagcat attatgtcgg agcggaatgt tctgttgaag aatgtgaagc      600

accctttcct ggtgggcctt cacttctctt tccagactgc tgacaaattg tactttgtcc      660

tagactacat taatggtgga gagttgttct accatctcca gagggaacgc tgcttcctgg      720

aaccacgggc tcgtttctat gctgctgaaa tagccagtgc cttgggctac ctgcattcac      780

tgaacatcgt ttatagagac ttaaaaccag agaatatttt gctagattca cagggacaca      840

ttgtccttac tgacttcgga ctctgcaagg agaacattga acacaacagc acaacatcca      900

ccttctgtgg cacgccggag tatctcgcac ctgaggtgct tcataagcag ccttatgaca      960

ggactgtgga ctggtggtgc ctgggagctg tcttgtatga gatgctgtat ggcctgccgc     1020

ctttttatag ccgaaacaca gctgaaatgt acgacaacat tctgaacaag cctctccagc     1080

tgaaaccaaa tattacaaat tccgcaagac acctcctgga gggcctcctg cagaaggaca     1140

ggacaaagcg gctcggggcc aaggatgact tcatggagat taagagtcat gtcttcttct     1200

ccttaattaa ctgggatgat ctcattaata agaagattac tccccctttt aacccaaatg     1260

tgagtgggcc caacgaccta cggcactttg accccgagtt taccgaagag cctgtcccca     1320

actccattgg caagtcccct gacagcgtcc tcgtcacagc cagcgtcaag gaagctgccg     1380

aggctttcct aggcttttcc tatgcgcctc ccacggactc tttcctctga accctgttag     1440

ggcttggttt taaaggattt tatgtgtgtt tccgaatgtt ttagttagcc ttttggtgga     1500

gccgccagct gacaggacat cttacaagag aatttgcaca tctctggaag cttagcaatc     1560

ttattgcaca ctgttcgctg gaagcttttt gaagagcaca ttctcctcag tgagctcatg     1620

aggttttcat ttttattctt ccttccaacg tggtgctatc tctgaaacga gcgttagagt     1680

gccgccttag acggaggcag gagtttcgtt agaaagcgga cgctgttcta aaaaaggtct     1740

cctgcagatc tgtctgggct gtgatgacga atattatgaa atgtgccttt tctgaagaga     1800

ttgtgttagc tccaaagctt ttcctatcgc agtgtttcag ttctttattt tcccttgtgg     1860

atatgctgtg tgaaccgtcg tgtgagtgtg gtatgcctga tcacagatgg attttgttat     1920

aagcatcaat gtgacacttg caggacacta caacgtggga cattgtttgt ttcttccata     1980

tttggaagat aaatttatgt gtagactttt ttgtaagata cggttaataa ctaaaattta     2040

ttgaaatggt cttgcaatga ctcgtattca gatgcttaaa gaaagcattg ctgctacaaa     2100

tatttctatt tttagaaagg gtttttatgg accaatgccc cagttgtcag tcagagccgt     2160

tggtgttttt cattgtttaa aatgtcacct gtaaaatggg cattatttat gttttttttt     2220

ttgcattcct gataattgta tgtattgtat aaagaacgtc tgtacattgg gttataacac     2280

tagtatattt aaacttacag gcttatttgt aatgtaaacc accattttaa tgtactgtaa     2340

ttaacatggt tataatacgt acaatccttc cctcatccca tcacacaact ttttttgtgt     2400

gtgataaact gattttggtt tgcaataaaa ccttgaaaaa tatttacata taaaaaaaa      2459


<210> 29
<211> 2638
<212> DNA
<213> Homo sapiens

<400> 29
acattcctga cctctccctc ccccttttcc ctctttcttt ccttccttcc tcctcttcca       60

agttctggga tttttcagcc ttgcttggtt ttggccaaaa gcacaaaaaa ggcgttttcg      120

gaagcgaccc gaccgtgcac aagggccatt tgtttgtttt gggactcggg gcaggaaatc      180

ttgcccggcc tgagtcacgg cggctccttc aaggaaacgt cagtgctcgc cggtcgctct      240

cgtctgccgc gcgccccgcc gcccgctgcc catgggggag atgcagggcg cgctggccag      300

agcccggctc gagtccctgc tgcggccccg ccacaaaaag agggccgagg cgcagaaaag      360

gagcgagtcc ttcctgctga gcggactggc tttcatgaag cagaggagga tgggtctgaa      420

cgactttatt cagaagattg ccaataactc ctatgcatgc aaacaccctg aagttcagtc      480

catcttgaag atctcccaac ctcaggagcc tgagcttatg aatgccaacc cttctcctcc      540

accaagtcct tctcagcaaa tcaaccttgg cccgtcgtcc aatcctcatg ctaaaccatc      600

tgactttcac ttcttgaaag tgatcggaaa gggcagtttt ggaaaggttc ttctagcaag      660

acacaaggca gaagaagtgt tctatgcagt caaagtttta cagaagaaag caatcctgaa      720

aaagaaagag gagaagcata ttatgtcgga gcggaatgtt ctgttgaaga atgtgaagca      780

ccctttcctg gtgggccttc acttctcttt ccagactgct gacaaattgt actttgtcct      840

agactacatt aatggtggag agttgttcta ccatctccag agggaacgct gcttcctgga      900

accacgggct cgtttctatg ctgctgaaat agccagtgcc ttgggctacc tgcattcact      960

gaacatcgtt tatagagact taaaaccaga gaatattttg ctagattcac agggacacat     1020

tgtccttact gacttcggac tctgcaagga gaacattgaa cacaacagca caacatccac     1080

cttctgtggc acgccggagt atctcgcacc tgaggtgctt cataagcagc cttatgacag     1140

gactgtggac tggtggtgcc tgggagctgt cttgtatgag atgctgtatg gcctgccgcc     1200

tttttatagc cgaaacacag ctgaaatgta cgacaacatt ctgaacaagc ctctccagct     1260

gaaaccaaat attacaaatt ccgcaagaca cctcctggag ggcctcctgc agaaggacag     1320

gacaaagcgg ctcggggcca aggatgactt catggagatt aagagtcatg tcttcttctc     1380

cttaattaac tgggatgatc tcattaataa gaagattact ccccctttta acccaaatgt     1440

gagtgggccc aacgacctac ggcactttga ccccgagttt accgaagagc ctgtccccaa     1500

ctccattggc aagtcccctg acagcgtcct cgtcacagcc agcgtcaagg aagctgccga     1560

ggctttccta ggcttttcct atgcgcctcc cacggactct ttcctctgaa ccctgttagg     1620

gcttggtttt aaaggatttt atgtgtgttt ccgaatgttt tagttagcct tttggtggag     1680

ccgccagctg acaggacatc ttacaagaga atttgcacat ctctggaagc ttagcaatct     1740

tattgcacac tgttcgctgg aagctttttg aagagcacat tctcctcagt gagctcatga     1800

ggttttcatt tttattcttc cttccaacgt ggtgctatct ctgaaacgag cgttagagtg     1860

ccgccttaga cggaggcagg agtttcgtta gaaagcggac gctgttctaa aaaaggtctc     1920

ctgcagatct gtctgggctg tgatgacgaa tattatgaaa tgtgcctttt ctgaagagat     1980

tgtgttagct ccaaagcttt tcctatcgca gtgtttcagt tctttatttt cccttgtgga     2040

tatgctgtgt gaaccgtcgt gtgagtgtgg tatgcctgat cacagatgga ttttgttata     2100

agcatcaatg tgacacttgc aggacactac aacgtgggac attgtttgtt tcttccatat     2160

ttggaagata aatttatgtg tagacttttt tgtaagatac ggttaataac taaaatttat     2220

tgaaatggtc ttgcaatgac tcgtattcag atgcttaaag aaagcattgc tgctacaaat     2280

atttctattt ttagaaaggg tttttatgga ccaatgcccc agttgtcagt cagagccgtt     2340

ggtgtttttc attgtttaaa atgtcacctg taaaatgggc attatttatg tttttttttt     2400

tgcattcctg ataattgtat gtattgtata aagaacgtct gtacattggg ttataacact     2460

agtatattta aacttacagg cttatttgta atgtaaacca ccattttaat gtactgtaat     2520

taacatggtt ataatacgta caatccttcc ctcatcccat cacacaactt tttttgtgtg     2580

tgataaactg attttggttt gcaataaaac cttgaaaaat atttacatat aaaaaaaa       2638


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
cttcccaccc acttgtgctt                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gaaaggtgcc agaggagacc                                                   20


<210> 32
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ccccctattt taatcggagt ac                                                22


<210> 33
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
ttttgaagag cacagaacac cct                                               23


<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
atgttcacat tagtacacct tgcc                                              24


<210> 35
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
tctcagatcc aggcttgctt actgtc                                            26


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
atggccccag atatgttcca                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
cccaaggtct cagagccagt                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
cgtctgggga gtaggcaaat                                                   20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
cccgagggag gatgtgaaac                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
accagactga atgtgcaagc                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
agggtttttg atggcactga                                                   20


<210> 42
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
gggataatgg tgattgagat ggctcgagcc atctcaatca ccattatcct tttt             54


<210> 43
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
ccggcacagg cttcaggtat cttatctcga gataagatac ctgaagcctg tgtttttg         58


<210> 44
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
ccatcttgtc gtcaatgtta tgaagc                                            26


<210> 45
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
agcttctggg ttgtctcctc agtgg                                             25


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
cagatctcca tgtgccagaa                                                   20


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
cttgcccatt gctttattgg                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
tgcaccacca actgcttagc                                                   20


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
ggcatggact gtggtcatga g                                                 21


<210> 50
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
gtctgcggcg gtgttctg                                                     18


<210> 51
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
tgccgaccca gcaagatc                                                     18


