                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  MUTANT NNK1 ALLELE AND ITS USE

<130>  JT/NNK1/480

<150>  EP 13197206.9
<151>  2013-12-13

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  2787
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atgtttacgt cgcagcgaca gcttcgacaa aatgggagtc cgatgtcatc atcacgttca       60

tcacaacatt cctctggtac agcgtcgccg atatcagact ctccagcatc gaatcgcagc      120

tatggaagag atctacgagg cttaatggga attgatatac ctgctaacga accagctttt      180

aacagggcca atagcagtga tacaatctat ttcaggccta agaagattta caaaatggaa      240

catgagcacc catcacgatc tactttagta caactgcaga caagatcgca gccggacgat      300

gtcgcaagta gtcaagtaaa ccctgaaggc ggaaccgacg atctagagct gggcgatccg      360

tgtggcaatc aatctttata cactataggg gcggagtacg ttccagattt agactttaca      420

aagctagtga atgagtggca aaagtccacc gaggatttgt atgagttcag aagcagtgcc      480

actccgcagg tacaaatcaa agacagtgga aagggaaact acgaactttg gagctcaccg      540

gatgcaatat tgactcaaaa caaacttcga agagatagtt tttcgcaaga gaacagtgat      600

tcgttaagtc cagaagattc tattttatca agaaatttgc attctaaggt caaacccatc      660

cctctgccca gaaacagcca gcaaatattt acacccctgt ccaacttaga agcggaaagg      720

agatcctcat atacaactag tagcaacaac aatagcataa cacagaataa taaattctct      780

tttgcgaagt taaagtattc acttccaact caaagttctg cagttcctgc gtcgttcgat      840

tcaaatgctt cgtcactaaa ttttcttccg actactacat tatcgacctt atcagagcta      900

caaataagcc ccaacgatat gatggatttg attcagaagc ttcccagaaa ttttttgaac      960

ttgccgtata ctcaaaggaa aaaggtgatt atcgagcatg caccatctca tgactacaag     1020

gccatgatgt ccctagttaa gaagtttatg ttaacatctt ctagaagtaa cttttctctc     1080

gctgggtttg ccaataatgc ttcagtttcg caggccacgg ctaatgatga taacatcaat     1140

agtaggaaca cgcccaataa tagcaatgac acctacgtaa atacgcgtcc acttcaaaga     1200

tctaggcacg gttccattgc atcccaattt ttaagttctt tttcaccttc gatgacgtca     1260

atagctaaaa tgaattcgaa cccattgagt ggaagcgcag gtggcagtgc gagaccagac     1320

gataagggta tggaaatact aggtcatcgg ttgggtaaaa tcataggttt cggcgcatgg     1380

gggatcatac gggaatgctt tgatattgaa actggtgttg gtagagtgat aaaaattgtg     1440

aagttcaaag gacaccaaaa tatcaagaaa catgtgctga gagaagtagc catatggagg     1500

actttgaagc ataacagaat actccccctt ttagattgga agcttgatga caactatgca     1560

atgtattgtt taacggaaag aattaacgat ggtaccttat acgacttggt aatatcttgg     1620

gacgaattca aacgttcgaa gataccattt gcagagagat gcagattgac cattttttta     1680

agcttacaac tattatctgc attaaagtac atgcattcca aaacgattgt tcatggtgac     1740

atcaaattag aaaactgtct gttacaaaaa gaaggtaaaa aatcggattg gaaggttttc     1800

ctatgcgatt ttggaatgag ttgccacttc gatgagaagc atgtttatcg taacgatact     1860

tttgatgaaa acttgagtag tggcaacagc catagaaaga gaaaaagtat tgaacaaact     1920

aatttgataa agtatcccac aaccaatttt ttacctgacg accgaactaa tgattttgac     1980

gctagtgaaa acttaaaata ccaatttgaa aatcgaaagc atcaaccgtt tacaccaaaa     2040

ggaatggtta gctccagttc acattcatta aagcatctca atcaaccatc ctcttcttct     2100

tcttctaatc tatttcacaa gccagcctct caacctcaac cacagcatcg gagtcccttt     2160

catgggaggc acaagacaac cgatttttca aacctggaac ccgaaccttc taaatatatc     2220

ggatctctgc cttacgcttc gccagaactt ctaagatact cagatgcaag acgttcaaaa     2280

tcagttgaaa tgcatattta tgattcacca gactcctctc aatcggaaat tagcgcagca     2340

tcatcatctt cctctaattt atcttctcta tcatcctcta caaaggcgtc cgcagtcacg     2400

aattccggtg taactacaag ttcaccgtct ggttcatcga ctgattttcc atgtattgtt     2460

tctcctttag gaccagcatc cgatatttgg gccttgggag taatgctata tacaatgtta     2520

gtaggaaaat taccctttaa tcatgagttc gaacctaggt tacgctctct gattaaagta     2580

ggcgaatttg accgattttc tttagctcag gtctgtaaat ttgacaggaa aaaaaatgaa     2640

ggaacgattg gtcaaggctt gtatgacaca gtcattggat gtttgacgat tgacttggat     2700

aagaggtgga aattgaaaag gattgaagaa gtccttcaaa acgaaatgaa cctaagcgag     2760

gccattcacg ataataatgg ctcatga                                         2787


<210>  2
<211>  928
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Phe Thr Ser Gln Arg Gln Leu Arg Gln Asn Gly Ser Pro Met Ser 
1               5                   10                  15      


Ser Ser Arg Ser Ser Gln His Ser Ser Gly Thr Ala Ser Pro Ile Ser 
            20                  25                  30          


Asp Ser Pro Ala Ser Asn Arg Ser Tyr Gly Arg Asp Leu Arg Gly Leu 
        35                  40                  45              


Met Gly Ile Asp Ile Pro Ala Asn Glu Pro Ala Phe Asn Arg Ala Asn 
    50                  55                  60                  


Ser Ser Asp Thr Ile Tyr Phe Arg Pro Lys Lys Ile Tyr Lys Met Glu 
65                  70                  75                  80  


His Glu His Pro Ser Arg Ser Thr Leu Val Gln Leu Gln Thr Arg Ser 
                85                  90                  95      


Gln Pro Asp Asp Val Ala Ser Ser Gln Val Asn Pro Glu Gly Gly Thr 
            100                 105                 110         


Asp Asp Leu Glu Leu Gly Asp Pro Cys Gly Asn Gln Ser Leu Tyr Thr 
        115                 120                 125             


Ile Gly Ala Glu Tyr Val Pro Asp Leu Asp Phe Thr Lys Leu Val Asn 
    130                 135                 140                 


Glu Trp Gln Lys Ser Thr Glu Asp Leu Tyr Glu Phe Arg Ser Ser Ala 
145                 150                 155                 160 


Thr Pro Gln Val Gln Ile Lys Asp Ser Gly Lys Gly Asn Tyr Glu Leu 
                165                 170                 175     


Trp Ser Ser Pro Asp Ala Ile Leu Thr Gln Asn Lys Leu Arg Arg Asp 
            180                 185                 190         


Ser Phe Ser Gln Glu Asn Ser Asp Ser Leu Ser Pro Glu Asp Ser Ile 
        195                 200                 205             


Leu Ser Arg Asn Leu His Ser Lys Val Lys Pro Ile Pro Leu Pro Arg 
    210                 215                 220                 


Asn Ser Gln Gln Ile Phe Thr Pro Leu Ser Asn Leu Glu Ala Glu Arg 
225                 230                 235                 240 


Arg Ser Ser Tyr Thr Thr Ser Ser Asn Asn Asn Ser Ile Thr Gln Asn 
                245                 250                 255     


Asn Lys Phe Ser Phe Ala Lys Leu Lys Tyr Ser Leu Pro Thr Gln Ser 
            260                 265                 270         


Ser Ala Val Pro Ala Ser Phe Asp Ser Asn Ala Ser Ser Leu Asn Phe 
        275                 280                 285             


Leu Pro Thr Thr Thr Leu Ser Thr Leu Ser Glu Leu Gln Ile Ser Pro 
    290                 295                 300                 


Asn Asp Met Met Asp Leu Ile Gln Lys Leu Pro Arg Asn Phe Leu Asn 
305                 310                 315                 320 


Leu Pro Tyr Thr Gln Arg Lys Lys Val Ile Ile Glu His Ala Pro Ser 
                325                 330                 335     


His Asp Tyr Lys Ala Met Met Ser Leu Val Lys Lys Phe Met Leu Thr 
            340                 345                 350         


Ser Ser Arg Ser Asn Phe Ser Leu Ala Gly Phe Ala Asn Asn Ala Ser 
        355                 360                 365             


Val Ser Gln Ala Thr Ala Asn Asp Asp Asn Ile Asn Ser Arg Asn Thr 
    370                 375                 380                 


Pro Asn Asn Ser Asn Asp Thr Tyr Val Asn Thr Arg Pro Leu Gln Arg 
385                 390                 395                 400 


Ser Arg His Gly Ser Ile Ala Ser Gln Phe Leu Ser Ser Phe Ser Pro 
                405                 410                 415     


Ser Met Thr Ser Ile Ala Lys Met Asn Ser Asn Pro Leu Ser Gly Ser 
            420                 425                 430         


Ala Gly Gly Ser Ala Arg Pro Asp Asp Lys Gly Met Glu Ile Leu Gly 
        435                 440                 445             


His Arg Leu Gly Lys Ile Ile Gly Phe Gly Ala Trp Gly Ile Ile Arg 
    450                 455                 460                 


Glu Cys Phe Asp Ile Glu Thr Gly Val Gly Arg Val Ile Lys Ile Val 
465                 470                 475                 480 


Lys Phe Lys Gly His Gln Asn Ile Lys Lys His Val Leu Arg Glu Val 
                485                 490                 495     


Ala Ile Trp Arg Thr Leu Lys His Asn Arg Ile Leu Pro Leu Leu Asp 
            500                 505                 510         


Trp Lys Leu Asp Asp Asn Tyr Ala Met Tyr Cys Leu Thr Glu Arg Ile 
        515                 520                 525             


Asn Asp Gly Thr Leu Tyr Asp Leu Val Ile Ser Trp Asp Glu Phe Lys 
    530                 535                 540                 


Arg Ser Lys Ile Pro Phe Ala Glu Arg Cys Arg Leu Thr Ile Phe Leu 
545                 550                 555                 560 


Ser Leu Gln Leu Leu Ser Ala Leu Lys Tyr Met His Ser Lys Thr Ile 
                565                 570                 575     


Val His Gly Asp Ile Lys Leu Glu Asn Cys Leu Leu Gln Lys Glu Gly 
            580                 585                 590         


Lys Lys Ser Asp Trp Lys Val Phe Leu Cys Asp Phe Gly Met Ser Cys 
        595                 600                 605             


His Phe Asp Glu Lys His Val Tyr Arg Asn Asp Thr Phe Asp Glu Asn 
    610                 615                 620                 


Leu Ser Ser Gly Asn Ser His Arg Lys Arg Lys Ser Ile Glu Gln Thr 
625                 630                 635                 640 


Asn Leu Ile Lys Tyr Pro Thr Thr Asn Phe Leu Pro Asp Asp Arg Thr 
                645                 650                 655     


Asn Asp Phe Asp Ala Ser Glu Asn Leu Lys Tyr Gln Phe Glu Asn Arg 
            660                 665                 670         


Lys His Gln Pro Phe Thr Pro Lys Gly Met Val Ser Ser Ser Ser His 
        675                 680                 685             


Ser Leu Lys His Leu Asn Gln Pro Ser Ser Ser Ser Ser Ser Asn Leu 
    690                 695                 700                 


Phe His Lys Pro Ala Ser Gln Pro Gln Pro Gln His Arg Ser Pro Phe 
705                 710                 715                 720 


His Gly Arg His Lys Thr Thr Asp Phe Ser Asn Leu Glu Pro Glu Pro 
                725                 730                 735     


Ser Lys Tyr Ile Gly Ser Leu Pro Tyr Ala Ser Pro Glu Leu Leu Arg 
            740                 745                 750         


Tyr Ser Asp Ala Arg Arg Ser Lys Ser Val Glu Met His Ile Tyr Asp 
        755                 760                 765             


Ser Pro Asp Ser Ser Gln Ser Glu Ile Ser Ala Ala Ser Ser Ser Ser 
    770                 775                 780                 


Ser Asn Leu Ser Ser Leu Ser Ser Ser Thr Lys Ala Ser Ala Val Thr 
785                 790                 795                 800 


Asn Ser Gly Val Thr Thr Ser Ser Pro Ser Gly Ser Ser Thr Asp Phe 
                805                 810                 815     


Pro Cys Ile Val Ser Pro Leu Gly Pro Ala Ser Asp Ile Trp Ala Leu 
            820                 825                 830         


Gly Val Met Leu Tyr Thr Met Leu Val Gly Lys Leu Pro Phe Asn His 
        835                 840                 845             


Glu Phe Glu Pro Arg Leu Arg Ser Leu Ile Lys Val Gly Glu Phe Asp 
    850                 855                 860                 


Arg Phe Ser Leu Ala Gln Val Cys Lys Phe Asp Arg Lys Lys Asn Glu 
865                 870                 875                 880 


Gly Thr Ile Gly Gln Gly Leu Tyr Asp Thr Val Ile Gly Cys Leu Thr 
                885                 890                 895     


Ile Asp Leu Asp Lys Arg Trp Lys Leu Lys Arg Ile Glu Glu Val Leu 
            900                 905                 910         


Gln Asn Glu Met Asn Leu Ser Glu Ala Ile His Asp Asn Asn Gly Ser 
        915                 920                 925             


<210>  3
<211>  2787
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  3
atgtttacgt cgcagcgaca gcttcgacaa aatgggagtc cgatgtcatc atcacgttca       60

tcacaacatt cctctggtac agcgtcgccg atatcagact ctccagcatc gaatcgcagc      120

tatggaagag atctacgagg cttaatggga attgatatac ctgctaacga accagctttt      180

aacagggcca atagcagtga tacaatctat ttcaggccta agaagattta caaaatggaa      240

catgagcacc catcacgatc tactttagta caactgcaga caagatcgca gccggacgat      300

gtcgcaagta gtcaagtaaa ccctgaaggc ggaaccgacg atctagagct gggcgatccg      360

tgtggcaatc aatctttata cactataggg gcggagtacg ttccagattt agactttaca      420

aagctagtga atgagtggca aaagtccacc gaggatttgt atgagttcag aagcagtgcc      480

actccgcagg tacaaatcaa agacagtgga aagggaaact acgaactttg gagctcaccg      540

gatgcaatat tgactcaaaa caaacttcga agagatagtt tttcgcaaga gaacagtgat      600

tcgttaagtc cagaagattc tattttatca agaaatttgc attctaaggt caaacccatc      660

cctctgccca gaaacagcca gcaaatattt acacccctgt ccaacttaga agcggaaagg      720

agatcctcat atacaactag tagcaacaac aatagcataa cacagaataa taaattctct      780

tttgcgaagt taaagtattc acttccaact caaagttctg cagttcctgc gtcgttcgat      840

tcaaatgctt cgtcactaaa ttttcttccg actactacat tatcgacctt atcagagcta      900

caaataagcc ccaacgatat gatggatttg attcagaagc ttcccagaaa ttttttgaac      960

ttgccgtata ctcaaaggaa aaaggtgatt atcgagcatg caccatctca tgactacaag     1020

gccatgatgt ccctagttaa gaagtttatg ttaacatctt ctagaagtaa cttttctctc     1080

gctgggtttg ccaataatgc ttcagtttcg caggccacgg ctaatgatga taacatcaat     1140

agtaggaaca cgcccaataa tagcaatgac acctacgtaa atacgcgtcc acttcaaaga     1200

tctaggcacg gttccattgc atcccaattt ttaagttctt tttcaccttc gatgacgtca     1260

atagctaaaa tgaattcgaa cccattgagt ggaagcgcag gtggcagtgc gagaccagac     1320

gataagggta tggaaatact aggtcatcgg ttgggtaaaa tcataggttt cggcgcatgg     1380

gggatcatac gggaatgctt tgatattgaa actggtgttg gtagagtgat aaaaattgtg     1440

aagttcaaag gacaccaaaa tatcaagaaa catgtgctga gagaagtagc catatggagg     1500

actttgaagc ataacagaat actccccctt ttagattgga agcttgatga caactatgca     1560

atgtattgtt taacggaaag aattaacgat ggtaccttat acgacttggt aatatcttgg     1620

gacgaattca aacgttcgaa gataccattt gcagagagat gcagattgac cattttttta     1680

agcttacaac tattatctgc attaaagtac atgcattcca aaacgattgt tcatggtgac     1740

atcaaattag aaaactgtct gttacaaaaa gaaggtaaaa aatcggattg gaaggttttc     1800

ctatgcgatt ttggaatgag ttgccacttc gatgagaagc atgtttatcg taacgatact     1860

tttgatgaaa acttgagtag tggcaacagc catagaaaga gaaaaagtat tgaacaaact     1920

aatttgataa agtatcccac aaccaatttt ttacctgacg accgaactaa tgattttgac     1980

gctagtgaaa acttaaaata ccaatttgaa aatcgaaagc atcaaccgtt tacaccaaaa     2040

ggaatggtta gctccagttc acattcatta aagcatctca atcaaccatc ctcttcttct     2100

tcttctaatc tatttcacaa gccagcctct caacctcaac cacagcatcg gagtcccttt     2160

catgggaggc acaagacaac cgatttttca aacctggaac ccgaaccttc taaatatatc     2220

ggatctctgc cttacgcttc gccagaactt ctaagatact cagatgcaag acgttcaaaa     2280

tcagttgaaa tgcatattta tgattcacca gactcctctc aatcggaaat tagcgcagca     2340

tcatcatctt cctctaattt atcttctcta tcatcctcta caaaggcgtc cgcagtcacg     2400

aattccggtg taactacaaa ttcaccgtct ggttcatcga ctgattttcc atgtattgtt     2460

tctcctttag gaccagcatc cgatatttgg gccttgggag taatgctata tacaatgtta     2520

gtaggaaaat taccctttaa tcatgagttc gaacctaggt tacgctctct gattaaagta     2580

ggcgaatttg accgattttc tttagctcag gtctgtaaat ttgacaggaa aaaaaatgaa     2640

ggaacgattg gtcaaggctt gtatgacaca gtcattggat gtttgacgat tgacttggat     2700

aagaggtgga aattgaaaag gattgaagaa gtccttcaaa acgaaatgaa cctaagcgag     2760

gccattcacg ataataatgg ctcatga                                         2787


<210>  4
<211>  928
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Phe Thr Ser Gln Arg Gln Leu Arg Gln Asn Gly Ser Pro Met Ser 
1               5                   10                  15      


Ser Ser Arg Ser Ser Gln His Ser Ser Gly Thr Ala Ser Pro Ile Ser 
            20                  25                  30          


Asp Ser Pro Ala Ser Asn Arg Ser Tyr Gly Arg Asp Leu Arg Gly Leu 
        35                  40                  45              


Met Gly Ile Asp Ile Pro Ala Asn Glu Pro Ala Phe Asn Arg Ala Asn 
    50                  55                  60                  


Ser Ser Asp Thr Ile Tyr Phe Arg Pro Lys Lys Ile Tyr Lys Met Glu 
65                  70                  75                  80  


His Glu His Pro Ser Arg Ser Thr Leu Val Gln Leu Gln Thr Arg Ser 
                85                  90                  95      


Gln Pro Asp Asp Val Ala Ser Ser Gln Val Asn Pro Glu Gly Gly Thr 
            100                 105                 110         


Asp Asp Leu Glu Leu Gly Asp Pro Cys Gly Asn Gln Ser Leu Tyr Thr 
        115                 120                 125             


Ile Gly Ala Glu Tyr Val Pro Asp Leu Asp Phe Thr Lys Leu Val Asn 
    130                 135                 140                 


Glu Trp Gln Lys Ser Thr Glu Asp Leu Tyr Glu Phe Arg Ser Ser Ala 
145                 150                 155                 160 


Thr Pro Gln Val Gln Ile Lys Asp Ser Gly Lys Gly Asn Tyr Glu Leu 
                165                 170                 175     


Trp Ser Ser Pro Asp Ala Ile Leu Thr Gln Asn Lys Leu Arg Arg Asp 
            180                 185                 190         


Ser Phe Ser Gln Glu Asn Ser Asp Ser Leu Ser Pro Glu Asp Ser Ile 
        195                 200                 205             


Leu Ser Arg Asn Leu His Ser Lys Val Lys Pro Ile Pro Leu Pro Arg 
    210                 215                 220                 


Asn Ser Gln Gln Ile Phe Thr Pro Leu Ser Asn Leu Glu Ala Glu Arg 
225                 230                 235                 240 


Arg Ser Ser Tyr Thr Thr Ser Ser Asn Asn Asn Ser Ile Thr Gln Asn 
                245                 250                 255     


Asn Lys Phe Ser Phe Ala Lys Leu Lys Tyr Ser Leu Pro Thr Gln Ser 
            260                 265                 270         


Ser Ala Val Pro Ala Ser Phe Asp Ser Asn Ala Ser Ser Leu Asn Phe 
        275                 280                 285             


Leu Pro Thr Thr Thr Leu Ser Thr Leu Ser Glu Leu Gln Ile Ser Pro 
    290                 295                 300                 


Asn Asp Met Met Asp Leu Ile Gln Lys Leu Pro Arg Asn Phe Leu Asn 
305                 310                 315                 320 


Leu Pro Tyr Thr Gln Arg Lys Lys Val Ile Ile Glu His Ala Pro Ser 
                325                 330                 335     


His Asp Tyr Lys Ala Met Met Ser Leu Val Lys Lys Phe Met Leu Thr 
            340                 345                 350         


Ser Ser Arg Ser Asn Phe Ser Leu Ala Gly Phe Ala Asn Asn Ala Ser 
        355                 360                 365             


Val Ser Gln Ala Thr Ala Asn Asp Asp Asn Ile Asn Ser Arg Asn Thr 
    370                 375                 380                 


Pro Asn Asn Ser Asn Asp Thr Tyr Val Asn Thr Arg Pro Leu Gln Arg 
385                 390                 395                 400 


Ser Arg His Gly Ser Ile Ala Ser Gln Phe Leu Ser Ser Phe Ser Pro 
                405                 410                 415     


Ser Met Thr Ser Ile Ala Lys Met Asn Ser Asn Pro Leu Ser Gly Ser 
            420                 425                 430         


Ala Gly Gly Ser Ala Arg Pro Asp Asp Lys Gly Met Glu Ile Leu Gly 
        435                 440                 445             


His Arg Leu Gly Lys Ile Ile Gly Phe Gly Ala Trp Gly Ile Ile Arg 
    450                 455                 460                 


Glu Cys Phe Asp Ile Glu Thr Gly Val Gly Arg Val Ile Lys Ile Val 
465                 470                 475                 480 


Lys Phe Lys Gly His Gln Asn Ile Lys Lys His Val Leu Arg Glu Val 
                485                 490                 495     


Ala Ile Trp Arg Thr Leu Lys His Asn Arg Ile Leu Pro Leu Leu Asp 
            500                 505                 510         


Trp Lys Leu Asp Asp Asn Tyr Ala Met Tyr Cys Leu Thr Glu Arg Ile 
        515                 520                 525             


Asn Asp Gly Thr Leu Tyr Asp Leu Val Ile Ser Trp Asp Glu Phe Lys 
    530                 535                 540                 


Arg Ser Lys Ile Pro Phe Ala Glu Arg Cys Arg Leu Thr Ile Phe Leu 
545                 550                 555                 560 


Ser Leu Gln Leu Leu Ser Ala Leu Lys Tyr Met His Ser Lys Thr Ile 
                565                 570                 575     


Val His Gly Asp Ile Lys Leu Glu Asn Cys Leu Leu Gln Lys Glu Gly 
            580                 585                 590         


Lys Lys Ser Asp Trp Lys Val Phe Leu Cys Asp Phe Gly Met Ser Cys 
        595                 600                 605             


His Phe Asp Glu Lys His Val Tyr Arg Asn Asp Thr Phe Asp Glu Asn 
    610                 615                 620                 


Leu Ser Ser Gly Asn Ser His Arg Lys Arg Lys Ser Ile Glu Gln Thr 
625                 630                 635                 640 


Asn Leu Ile Lys Tyr Pro Thr Thr Asn Phe Leu Pro Asp Asp Arg Thr 
                645                 650                 655     


Asn Asp Phe Asp Ala Ser Glu Asn Leu Lys Tyr Gln Phe Glu Asn Arg 
            660                 665                 670         


Lys His Gln Pro Phe Thr Pro Lys Gly Met Val Ser Ser Ser Ser His 
        675                 680                 685             


Ser Leu Lys His Leu Asn Gln Pro Ser Ser Ser Ser Ser Ser Asn Leu 
    690                 695                 700                 


Phe His Lys Pro Ala Ser Gln Pro Gln Pro Gln His Arg Ser Pro Phe 
705                 710                 715                 720 


His Gly Arg His Lys Thr Thr Asp Phe Ser Asn Leu Glu Pro Glu Pro 
                725                 730                 735     


Ser Lys Tyr Ile Gly Ser Leu Pro Tyr Ala Ser Pro Glu Leu Leu Arg 
            740                 745                 750         


Tyr Ser Asp Ala Arg Arg Ser Lys Ser Val Glu Met His Ile Tyr Asp 
        755                 760                 765             


Ser Pro Asp Ser Ser Gln Ser Glu Ile Ser Ala Ala Ser Ser Ser Ser 
    770                 775                 780                 


Ser Asn Leu Ser Ser Leu Ser Ser Ser Thr Lys Ala Ser Ala Val Thr 
785                 790                 795                 800 


Asn Ser Gly Val Thr Thr Asn Ser Pro Ser Gly Ser Ser Thr Asp Phe 
                805                 810                 815     


Pro Cys Ile Val Ser Pro Leu Gly Pro Ala Ser Asp Ile Trp Ala Leu 
            820                 825                 830         


Gly Val Met Leu Tyr Thr Met Leu Val Gly Lys Leu Pro Phe Asn His 
        835                 840                 845             


Glu Phe Glu Pro Arg Leu Arg Ser Leu Ile Lys Val Gly Glu Phe Asp 
    850                 855                 860                 


Arg Phe Ser Leu Ala Gln Val Cys Lys Phe Asp Arg Lys Lys Asn Glu 
865                 870                 875                 880 


Gly Thr Ile Gly Gln Gly Leu Tyr Asp Thr Val Ile Gly Cys Leu Thr 
                885                 890                 895     


Ile Asp Leu Asp Lys Arg Trp Lys Leu Lys Arg Ile Glu Glu Val Leu 
            900                 905                 910         


Gln Asn Glu Met Asn Leu Ser Glu Ala Ile His Asp Asn Asn Gly Ser 
        915                 920                 925             


<210>  5
<211>  18
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  5
acgagagcta cctaagtc                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  6
acgagagcta ccgaagtc                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  7
acgatagcta ccgaagtc                                                     18


