                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Dual GLP-1/GIP Receptor Agonists

<130>  DE2013/241

<150>  EP13306713.2
<151>  2013-12-13

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Liraglutide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys derivatized at N6 with 
       (S)-4-carboxy-4-hexadecanoylamino-butyryl

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  4
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  5
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  6

Tyr Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP1 analogue


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  7

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ile Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  8

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  9

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  10

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  11

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Amidated C-terminus

<400>  12

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  L-methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  13

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  L-methionine-sulfone

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  14

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  15

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  16

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Xaa Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  (S)-alpha-methyl lysine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  17

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Lys Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  (R)-alpha-methyl lysine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  18

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Lys Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is (S)-alpha-methyl ornithine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  19

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Xaa Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  20

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


