                         SEQUENCE LISTING

<110>  Moderna Therapeutics, Inc.
 
<120>  TARGETED ADAPTIVE VACCINES

<130>  3529.004PC03/ELE/BN-C

<140>  To be assigned
<141>  Herewith

<150>  61/912,635
<151>  2013-12-06

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  self-cleaving 2A peptide

<400>  1

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  2
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  self-cleaving 2A peptide

<400>  2
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  3
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-001 (Upstream UTR)

<400>  3
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  4
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-002 (Upstream UTR)

<400>  4
gggagatcag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  5
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-003 (Upstream UTR)

<400>  5
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcaac                                            145


<210>  6
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5UTR-004 (Upstream UTR)

<400>  6
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  7
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-005 (Upstream UTR)

<400>  7
gggagatcag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  8
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-006 (Upstream UTR)

<400>  8
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcaac                                            145


<210>  9
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5UTR-007 (Upstream UTR)

<400>  9
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  10
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-008 (Upstream UTR)

<400>  10
gggaattaac agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  11
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-009 (Upstream UTR)

<400>  11
gggaaattag acagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  12
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-010 (Upstream UTR)

<400>  12
gggaaataag agagtaaaga acagtaagaa gaaatataag agccacc                     47


<210>  13
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-011 (Upstream UTR)

<400>  13
gggaaaaaag agagaaaaga agactaagaa gaaatataag agccacc                     47


<210>  14
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-012 (Upstream UTR)

<400>  14
gggaaataag agagaaaaga agagtaagaa gatatataag agccacc                     47


<210>  15
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-013 (Upstream UTR)

<400>  15
gggaaataag agacaaaaca agagtaagaa gaaatataag agccacc                     47


<210>  16
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-014 (Upstream UTR)

<400>  16
gggaaattag agagtaaaga acagtaagta gaattaaaag agccacc                     47


<210>  17
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-015 (Upstream UTR)

<400>  17
gggaaataag agagaataga agagtaagaa gaaatataag agccacc                     47


<210>  18
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-016 (Upstream UTR)

<400>  18
gggaaataag agagaaaaga agagtaagaa gaaaattaag agccacc                     47


<210>  19
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-017 (Upstream UTR)

<400>  19
gggaaataag agagaaaaga agagtaagaa gaaatttaag agccacc                     47


<210>  20
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-001 (Creatine Kinase)

<400>  20
gcgcctgccc acctgccacc gactgctgga acccagccag tgggagggcc tggcccacca       60

gagtcctgct ccctcactcc tcgccccgcc ccctgtccca gagtcccacc tgggggctct      120

ctccaccctt ctcagagttc cagtttcaac cagagttcca accaatgggc tccatcctct      180

ggattctggc caatgaaata tctccctggc agggtcctct tcttttccca gagctccacc      240

ccaaccagga gctctagtta atggagagct cccagcacac tcggagcttg tgctttgtct      300

ccacgcaaag cgataaataa aagcattggt ggcctttggt ctttgaataa agcctgagta      360

ggaagtctag a                                                           371


<210>  21
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-002 (Myoglobin)

<400>  21
gcccctgccg ctcccacccc cacccatctg ggccccgggt tcaagagaga gcggggtctg       60

atctcgtgta gccatataga gtttgcttct gagtgtctgc tttgtttagt agaggtgggc      120

aggaggagct gaggggctgg ggctggggtg ttgaagttgg ctttgcatgc ccagcgatgc      180

gcctccctgt gggatgtcat caccctggga accgggagtg gcccttggct cactgtgttc      240

tgcatggttt ggatctgaat taattgtcct ttcttctaaa tcccaaccga acttcttcca      300

acctccaaac tggctgtaac cccaaatcca agccattaac tacacctgac agtagcaatt      360

gtctgattaa tcactggccc cttgaagaca gcagaatgtc cctttgcaat gaggaggaga      420

tctgggctgg gcgggccagc tggggaagca tttgactatc tggaacttgt gtgtgcctcc      480

tcaggtatgg cagtgactca cctggtttta ataaaacaac ctgcaacatc tcatggtctt      540

tgaataaagc ctgagtagga agtctaga                                         568


<210>  22
<211>  289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-003 (alpha-actin)

<400>  22
acacactcca cctccagcac gcgacttctc aggacgacga atcttctcaa tgggggggcg       60

gctgagctcc agccaccccg cagtcacttt ctttgtaaca acttccgttg ctgccatcgt      120

aaactgacac agtgtttata acgtgtacat acattaactt attacctcat tttgttattt      180

ttcgaaacaa agccctgtgg aagaaaatgg aaaacttgaa gaagcattaa agtcattctg      240

ttaagctgcg taaatggtct ttgaataaag cctgagtagg aagtctaga                  289


<210>  23
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-004 (Albumin)

<400>  23
catcacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa tgaagatcaa       60

aagcttattc atctgttttt ctttttcgtt ggtgtaaagc caacaccctg tctaaaaaac      120

ataaatttct ttaatcattt tgcctctttt ctctgtgctt caattaataa aaaatggaaa      180

gaatctaata gagtggtaca gcactgttat ttttcaaaga tgtgttgcta tcctgaaaat      240

tctgtaggtt ctgtggaagt tccagtgttc tctcttattc cacttcggta gaggatttct      300

agtttcttgt gggctaatta aataaatcat taatactctt ctaatggtct ttgaataaag      360

cctgagtagg aagtctaga                                                   379


<210>  24
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-005 (alpha-globin)

<400>  24
gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac       60

ctcttggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg catctaga        118


<210>  25
<211>  908
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-006 (G-CSF)

<400>  25
gccaagccct ccccatccca tgtatttatc tctatttaat atttatgtct atttaagcct       60

catatttaaa gacagggaag agcagaacgg agccccaggc ctctgtgtcc ttccctgcat      120

ttctgagttt cattctcctg cctgtagcag tgagaaaaag ctcctgtcct cccatcccct      180

ggactgggag gtagataggt aaataccaag tatttattac tatgactgct ccccagccct      240

ggctctgcaa tgggcactgg gatgagccgc tgtgagcccc tggtcctgag ggtccccacc      300

tgggaccctt gagagtatca ggtctcccac gtgggagaca agaaatccct gtttaatatt      360

taaacagcag tgttccccat ctgggtcctt gcacccctca ctctggcctc agccgactgc      420

acagcggccc ctgcatcccc ttggctgtga ggcccctgga caagcagagg tggccagagc      480

tgggaggcat ggccctgggg tcccacgaat ttgctgggga atctcgtttt tcttcttaag      540

acttttggga catggtttga ctcccgaaca tcaccgacgc gtctcctgtt tttctgggtg      600

gcctcgggac acctgccctg cccccacgag ggtcaggact gtgactcttt ttagggccag      660

gcaggtgcct ggacatttgc cttgctggac ggggactggg gatgtgggag ggagcagaca      720

ggaggaatca tgtcaggcct gtgtgtgaaa ggaagctcca ctgtcaccct ccacctcttc      780

accccccact caccagtgtc ccctccactg tcacattgta actgaacttc aggataataa      840

agtgtttgcc tccatggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg      900

catctaga                                                               908


<210>  26
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-007 (Col1a2; collagen, type I, alpha 2)

<400>  26
actcaatcta aattaaaaaa gaaagaaatt tgaaaaaact ttctctttgc catttcttct       60

tcttcttttt taactgaaag ctgaatcctt ccatttcttc tgcacatcta cttgcttaaa      120

ttgtgggcaa aagagaaaaa gaaggattga tcagagcatt gtgcaataca gtttcattaa      180

ctccttcccc cgctccccca aaaatttgaa tttttttttc aacactctta cacctgttat      240

ggaaaatgtc aacctttgta agaaaaccaa aataaaaatt gaaaaataaa aaccataaac      300

atttgcacca cttgtggctt ttgaatatct tccacagagg gaagtttaaa acccaaactt      360

ccaaaggttt aaactacctc aaaacacttt cccatgagtg tgatccacat tgttaggtgc      420

tgacctagac agagatgaac tgaggtcctt gttttgtttt gttcataata caaaggtgct      480

aattaatagt atttcagata cttgaagaat gttgatggtg ctagaagaat ttgagaagaa      540

atactcctgt attgagttgt atcgtgtggt gtatttttta aaaaatttga tttagcattc      600

atattttcca tcttattccc aattaaaagt atgcagatta tttgcccaaa tcttcttcag      660

attcagcatt tgttctttgc cagtctcatt ttcatcttct tccatggttc cacagaagct      720

ttgtttcttg ggcaagcaga aaaattaaat tgtacctatt ttgtatatgt gagatgttta      780

aataaattgt gaaaaaaatg aaataaagca tgtttggttt tccaaaagaa catat           835


<210>  27
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-008 (Col6a2; collagen, type VI, alpha 2)

<400>  27
cgccgccgcc cgggccccgc agtcgagggt cgtgagccca ccccgtccat ggtgctaagc       60

gggcccgggt cccacacggc cagcaccgct gctcactcgg acgacgccct gggcctgcac      120

ctctccagct cctcccacgg ggtccccgta gccccggccc ccgcccagcc ccaggtctcc      180

ccaggccctc cgcaggctgc ccggcctccc tccccctgca gccatcccaa ggctcctgac      240

ctacctggcc cctgagctct ggagcaagcc ctgacccaat aaaggctttg aacccat         297


<210>  28
<211>  602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-009 (RPN1; ribophorin I)

<400>  28
ggggctagag ccctctccgc acagcgtgga gacggggcaa ggaggggggt tattaggatt       60

ggtggttttg ttttgctttg tttaaagccg tgggaaaatg gcacaacttt acctctgtgg      120

gagatgcaac actgagagcc aaggggtggg agttgggata atttttatat aaaagaagtt      180

tttccacttt gaattgctaa aagtggcatt tttcctatgt gcagtcactc ctctcatttc      240

taaaataggg acgtggccag gcacggtggc tcatgcctgt aatcccagca ctttgggagg      300

ccgaggcagg cggctcacga ggtcaggaga tcgagactat cctggctaac acggtaaaac      360

cctgtctcta ctaaaagtac aaaaaattag ctgggcgtgg tggtgggcac ctgtagtccc      420

agctactcgg gaggctgagg caggagaaag gcatgaatcc aagaggcaga gcttgcagtg      480

agctgagatc acgccattgc actccagcct gggcaacagt gttaagactc tgtctcaaat      540

ataaataaat aaataaataa ataaataaat aaataaaaat aaagcgagat gttgccctca      600

aa                                                                     602


<210>  29
<211>  785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-010 (LRP1; low density lipoprotein receptor-related protein 
       1)

<400>  29
ggccctgccc cgtcggactg cccccagaaa gcctcctgcc ccctgccagt gaagtccttc       60

agtgagcccc tccccagcca gcccttccct ggccccgccg gatgtataaa tgtaaaaatg      120

aaggaattac attttatatg tgagcgagca agccggcaag cgagcacagt attatttctc      180

catcccctcc ctgcctgctc cttggcaccc ccatgctgcc ttcagggaga caggcaggga      240

gggcttgggg ctgcacctcc taccctccca ccagaacgca ccccactggg agagctggtg      300

gtgcagcctt cccctccctg tataagacac tttgccaagg ctctcccctc tcgccccatc      360

cctgcttgcc cgctcccaca gcttcctgag ggctaattct gggaagggag agttctttgc      420

tgcccctgtc tggaagacgt ggctctgggt gaggtaggcg ggaaaggatg gagtgtttta      480

gttcttgggg gaggccaccc caaaccccag ccccaactcc aggggcacct atgagatggc      540

catgctcaac ccccctccca gacaggccct ccctgtctcc agggccccca ccgaggttcc      600

cagggctgga gacttcctct ggtaaacatt cctccagcct cccctcccct ggggacgcca      660

aggaggtggg ccacacccag gaagggaaag cgggcagccc cgttttgggg acgtgaacgt      720

tttaataatt tttgctgaat tcctttacaa ctaaataaca cagatattgt tataaataaa      780

attgt                                                                  785


<210>  30
<211>  3001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-011 (Nnt1; cardiotrophin-like cytokine factor 1)

<400>  30
atattaagga tcaagctgtt agctaataat gccacctctg cagttttggg aacaggcaaa       60

taaagtatca gtatacatgg tgatgtacat ctgtagcaaa gctcttggag aaaatgaaga      120

ctgaagaaag caaagcaaaa actgtataga gagatttttc aaaagcagta atccctcaat      180

tttaaaaaag gattgaaaat tctaaatgtc tttctgtgca tattttttgt gttaggaatc      240

aaaagtattt tataaaagga gaaagaacag cctcatttta gatgtagtcc tgttggattt      300

tttatgcctc ctcagtaacc agaaatgttt taaaaaacta agtgtttagg atttcaagac      360

aacattatac atggctctga aatatctgac acaatgtaaa cattgcaggc acctgcattt      420

tatgtttttt ttttcaacaa atgtgactaa tttgaaactt ttatgaactt ctgagctgtc      480

cccttgcaat tcaaccgcag tttgaattaa tcatatcaaa tcagttttaa ttttttaaat      540

tgtacttcag agtctatatt tcaagggcac attttctcac tactatttta atacattaaa      600

ggactaaata atctttcaga gatgctggaa acaaatcatt tgctttatat gtttcattag      660

aataccaatg aaacatacaa cttgaaaatt agtaatagta tttttgaaga tcccatttct      720

aattggagat ctctttaatt tcgatcaact tataatgtgt agtactatat taagtgcact      780

tgagtggaat tcaacatttg actaataaaa tgagttcatc atgttggcaa gtgatgtggc      840

aattatctct ggtgacaaaa gagtaaaatc aaatatttct gcctgttaca aatatcaagg      900

aagacctgct actatgaaat agatgacatt aatctgtctt cactgtttat aatacggatg      960

gatttttttt caaatcagtg tgtgttttga ggtcttatgt aattgatgac atttgagaga     1020

aatggtggct ttttttagct acctctttgt tcatttaagc accagtaaag atcatgtctt     1080

tttatagaag tgtagatttt ctttgtgact ttgctatcgt gcctaaagct ctaaatatag     1140

gtgaatgtgt gatgaatact cagattattt gtctctctat ataattagtt tggtactaag     1200

tttctcaaaa aattattaac acatgaaaga caatctctaa accagaaaaa gaagtagtac     1260

aaattttgtt actgtaatgc tcgcgtttag tgagtttaaa acacacagta tcttttggtt     1320

ttataatcag tttctatttt gctgtgcctg agattaagat ctgtgtatgt gtgtgtgtgt     1380

gtgtgtgcgt ttgtgtgtta aagcagaaaa gactttttta aaagttttaa gtgataaatg     1440

caatttgtta attgatctta gatcactagt aaactcaggg ctgaattata ccatgtatat     1500

tctattagaa gaaagtaaac accatcttta ttcctgccct ttttcttctc tcaaagtagt     1560

tgtagttata tctagaaaga agcaattttg atttcttgaa aaggtagttc ctgcactcag     1620

tttaaactaa aaataatcat acttggattt tatttatttt tgtcatagta aaaattttaa     1680

tttatatata tttttattta gtattatctt attctttgct atttgccaat cctttgtcat     1740

caattgtgtt aaatgaattg aaaattcatg ccctgttcat tttattttac tttattggtt     1800

aggatattta aaggattttt gtatatataa tttcttaaat taatattcca aaaggttagt     1860

ggacttagat tataaattat ggcaaaaatc taaaaacaac aaaaatgatt tttatacatt     1920

ctatttcatt attcctcttt ttccaataag tcatacaatt ggtagatatg acttatttta     1980

tttttgtatt attcactata tctttatgat atttaagtat aaataattaa aaaaatttat     2040

tgtaccttat agtctgtcac caaaaaaaaa aaattatctg taggtagtga aatgctaatg     2100

ttgatttgtc tttaagggct tgttaactat cctttatttt ctcatttgtc ttaaattagg     2160

agtttgtgtt taaattactc atctaagcaa aaaatgtata taaatcccat tactgggtat     2220

atacccaaag gattataaat catgctgcta taaagacaca tgcacacgta tgtttattgc     2280

agcactattc acaatagcaa agacttggaa ccaacccaaa tgtccatcaa tgatagactt     2340

gattaagaaa atgtgcacat atacaccatg gaatactatg cagccataaa aaaggatgag     2400

ttcatgtcct ttgtagggac atggataaag ctggaaacca tcattctgag caaactattg     2460

caaggacaga aaaccaaaca ctgcatgttc tcactcatag gtgggaattg aacaatgaga     2520

acacttggac acaaggtggg gaacaccaca caccagggcc tgtcatgggg tggggggagt     2580

ggggagggat agcattagga gatataccta atgtaaatga tgagttaatg ggtgcagcac     2640

accaacatgg cacatgtata catatgtagc aaacctgcac gttgtgcaca tgtaccctag     2700

aacttaaagt ataattaaaa aaaaaaagaa aacagaagct atttataaag aagttatttg     2760

ctgaaataaa tgtgatcttt cccattaaaa aaataaagaa attttggggt aaaaaaacac     2820

aatatattgt attcttgaaa aattctaaga gagtggatgt gaagtgttct caccacaaaa     2880

gtgataacta attgaggtaa tgcacatatt aattagaaag attttgtcat tccacaatgt     2940

atatatactt aaaaatatgt tatacacaat aaatacatac attaaaaaat aagtaaatgt     3000

a                                                                     3001


<210>  31
<211>  1037
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-012 (Col6a1; collagen, type VI, alpha 1)

<400>  31
cccaccctgc acgccggcac caaaccctgt cctcccaccc ctccccactc atcactaaac       60

agagtaaaat gtgatgcgaa ttttcccgac caacctgatt cgctagattt tttttaagga      120

aaagcttgga aagccaggac acaacgctgc tgcctgcttt gtgcagggtc ctccggggct      180

cagccctgag ttggcatcac ctgcgcaggg ccctctgggg ctcagccctg agctagtgtc      240

acctgcacag ggccctctga ggctcagccc tgagctggcg tcacctgtgc agggccctct      300

ggggctcagc cctgagctgg cctcacctgg gttccccacc ccgggctctc ctgccctgcc      360

ctcctgcccg ccctccctcc tgcctgcgca gctccttccc taggcacctc tgtgctgcat      420

cccaccagcc tgagcaagac gccctctcgg ggcctgtgcc gcactagcct ccctctcctc      480

tgtccccata gctggttttt cccaccaatc ctcacctaac agttacttta caattaaact      540

caaagcaagc tcttctcctc agcttggggc agccattggc ctctgtctcg ttttgggaaa      600

ccaaggtcag gaggccgttg cagacataaa tctcggcgac tcggccccgt ctcctgaggg      660

tcctgctggt gaccggcctg gaccttggcc ctacagccct ggaggccgct gctgaccagc      720

actgaccccg acctcagaga gtactcgcag gggcgctggc tgcactcaag accctcgaga      780

ttaacggtgc taaccccgtc tgctcctccc tcccgcagag actggggcct ggactggaca      840

tgagagcccc ttggtgccac agagggctgt gtcttactag aaacaacgca aacctctcct      900

tcctcagaat agtgatgtgt tcgacgtttt atcaaaggcc ccctttctat gttcatgtta      960

gttttgctcc ttctgtgttt ttttctgaac catatccatg ttgctgactt ttccaaataa     1020

aggttttcac tcctctc                                                    1037


<210>  32
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-013 (Calr; calreticulin)

<400>  32
agaggcctgc ctccagggct ggactgaggc ctgagcgctc ctgccgcaga gctggccgcg       60

ccaaataatg tctctgtgag actcgagaac tttcattttt ttccaggctg gttcggattt      120

ggggtggatt ttggttttgt tcccctcctc cactctcccc caccccctcc ccgccctttt      180

tttttttttt ttttaaactg gtattttatc tttgattctc cttcagccct cacccctggt      240

tctcatcttt cttgatcaac atcttttctt gcctctgtcc ccttctctca tctcttagct      300

cccctccaac ctggggggca gtggtgtgga gaagccacag gcctgagatt tcatctgctc      360

tccttcctgg agcccagagg agggcagcag aagggggtgg tgtctccaac cccccagcac      420

tgaggaagaa cggggctctt ctcatttcac ccctcccttt ctcccctgcc cccaggactg      480

ggccacttct gggtggggca gtgggtccca gattggctca cactgagaat gtaagaacta      540

caaacaaaat ttctattaaa ttaaattttg tgtctcc                               577


<210>  33
<211>  2212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-014 (Col1a1; collagen, type I, alpha 1)

<400>  33
ctccctccat cccaacctgg ctccctccca cccaaccaac tttcccccca acccggaaac       60

agacaagcaa cccaaactga accccctcaa aagccaaaaa atgggagaca atttcacatg      120

gactttggaa aatatttttt tcctttgcat tcatctctca aacttagttt ttatctttga      180

ccaaccgaac atgaccaaaa accaaaagtg cattcaacct taccaaaaaa aaaaaaaaaa      240

aaagaataaa taaataactt tttaaaaaag gaagcttggt ccacttgctt gaagacccat      300

gcgggggtaa gtccctttct gcccgttggg cttatgaaac cccaatgctg ccctttctgc      360

tcctttctcc acacccccct tggggcctcc cctccactcc ttcccaaatc tgtctcccca      420

gaagacacag gaaacaatgt attgtctgcc cagcaatcaa aggcaatgct caaacaccca      480

agtggccccc accctcagcc cgctcctgcc cgcccagcac ccccaggccc tgggggacct      540

ggggttctca gactgccaaa gaagccttgc catctggcgc tcccatggct cttgcaacat      600

ctccccttcg tttttgaggg ggtcatgccg ggggagccac cagcccctca ctgggttcgg      660

aggagagtca ggaagggcca cgacaaagca gaaacatcgg atttggggaa cgcgtgtcaa      720

tcccttgtgc cgcagggctg ggcgggagag actgttctgt tccttgtgta actgtgttgc      780

tgaaagacta cctcgttctt gtcttgatgt gtcaccgggg caactgcctg ggggcgggga      840

tgggggcagg gtggaagcgg ctccccattt tataccaaag gtgctacatc tatgtgatgg      900

gtggggtggg gagggaatca ctggtgctat agaaattgag atgccccccc aggccagcaa      960

atgttccttt ttgttcaaag tctattttta ttccttgata tttttctttt tttttttttt     1020

tttttgtgga tggggacttg tgaatttttc taaaggtgct atttaacatg ggaggagagc     1080

gtgtgcggct ccagcccagc ccgctgctca ctttccaccc tctctccacc tgcctctggc     1140

ttctcaggcc tctgctctcc gacctctctc ctctgaaacc ctcctccaca gctgcagccc     1200

atcctcccgg ctccctccta gtctgtcctg cgtcctctgt ccccgggttt cagagacaac     1260

ttcccaaagc acaaagcagt ttttccccct aggggtggga ggaagcaaaa gactctgtac     1320

ctattttgta tgtgtataat aatttgagat gtttttaatt attttgattg ctggaataaa     1380

gcatgtggaa atgacccaaa cataatccgc agtggcctcc taatttcctt ctttggagtt     1440

gggggagggg tagacatggg gaaggggctt tggggtgatg ggcttgcctt ccattcctgc     1500

cctttccctc cccactattc tcttctagat ccctccataa ccccactccc ctttctctca     1560

cccttcttat accgcaaacc tttctacttc ctctttcatt ttctattctt gcaatttcct     1620

tgcacctttt ccaaatcctc ttctcccctg caataccata caggcaatcc acgtgcacaa     1680

cacacacaca cactcttcac atctggggtt gtccaaacct catacccact ccccttcaag     1740

cccatccact ctccaccccc tggatgccct gcacttggtg gcggtgggat gctcatggat     1800

actgggaggg tgaggggagt ggaacccgtg aggaggacct gggggcctct ccttgaactg     1860

acatgaaggg tcatctggcc tctgctccct tctcacccac gctgacctcc tgccgaagga     1920

gcaacgcaac aggagagggg tctgctgagc ctggcgaggg tctgggaggg accaggagga     1980

aggcgtgctc cctgctcgct gtcctggccc tgggggagtg agggagacag acacctggga     2040

gagctgtggg gaaggcactc gcaccgtgct cttgggaagg aaggagacct ggccctgctc     2100

accacggact gggtgcctcg acctcctgaa tccccagaac acaacccccc tgggctgggg     2160

tggtctgggg aaccatcgtg cccccgcctc ccgcctactc ctttttaagc tt             2212


<210>  34
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-015 (Plod1; procollagen-lysine, 2-oxoglutarate 5-dioxygenase
       1)

<400>  34
ttggccaggc ctgaccctct tggacctttc ttctttgccg acaaccactg cccagcagcc       60

tctgggacct cggggtccca gggaacccag tccagcctcc tggctgttga cttcccattg      120

ctcttggagc caccaatcaa agagattcaa agagattcct gcaggccaga ggcggaacac      180

acctttatgg ctggggctct ccgtggtgtt ctggacccag cccctggaga caccattcac      240

ttttactgct ttgtagtgac tcgtgctctc caacctgtct tcctgaaaaa ccaaggcccc      300

cttcccccac ctcttccatg gggtgagact tgagcagaac aggggcttcc ccaagttgcc      360

cagaaagact gtctgggtga gaagccatgg ccagagcttc tcccaggcac aggtgttgca      420

ccagggactt ctgcttcaag ttttggggta aagacacctg gatcagactc caagggctgc      480

cctgagtctg ggacttctgc ctccatggct ggtcatgaga gcaaaccgta gtcccctgga      540

gacagcgact ccagagaacc tcttgggaga cagaagaggc atctgtgcac agctcgatct      600

tctacttgcc tgtggggagg ggagtgacag gtccacacac cacactgggt caccctgtcc      660

tggatgcctc tgaagagagg gacagaccgt cagaaactgg agagtttcta ttaaaggtca      720

tttaaacca                                                              729


<210>  35
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-016 (Nucb1; nucleobindin 1)

<400>  35
tcctccggga ccccagccct caggattcct gatgctccaa ggcgactgat gggcgctgga       60

tgaagtggca cagtcagctt ccctgggggc tggtgtcatg ttgggctcct ggggcggggg      120

cacggcctgg catttcacgc attgctgcca ccccaggtcc acctgtctcc actttcacag      180

cctccaagtc tgtggctctt cccttctgtc ctccgagggg cttgccttct ctcgtgtcca      240

gtgaggtgct cagtgatcgg cttaacttag agaagcccgc cccctcccct tctccgtctg      300

tcccaagagg gtctgctctg agcctgcgtt cctaggtggc tcggcctcag ctgcctgggt      360

tgtggccgcc ctagcatcct gtatgcccac agctactgga atccccgctg ctgctccggg      420

ccaagcttct ggttgattaa tgagggcatg gggtggtccc tcaagacctt cccctacctt      480

ttgtggaacc agtgatgcct caaagacagt gtcccctcca cagctgggtg ccaggggcag      540

gggatcctca gtatagccgg tgaaccctga taccaggagc ctgggcctcc ctgaacccct      600

ggcttccagc catctcatcg ccagcctcct cctggacctc ttggccccca gccccttccc      660

cacacagccc cagaagggtc ccagagctga ccccactcca ggacctaggc ccagcccctc      720

agcctcatct ggagcccctg aagaccagtc ccacccacct ttctggcctc atctgacact      780

gctccgcatc ctgctgtgtg tcctgttcca tgttccggtt ccatccaaat acactttctg      840

gaacaaa                                                                847


<210>  36
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-017 (alpha-globin)

<400>  36
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc                 110


<210>  37
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PCSK9 (Full length)

<400>  37

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  38
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine PCSK9 (Full length)

<400>  38

Met Gly Thr His Cys Ser Ala Trp Leu Arg Trp Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ala 
            20                  25                  30          


Gly Ala Gln Asp Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu 
        35                  40                  45              


Pro Ser Gln Glu Asp Gly Leu Ala Asp Glu Ala Ala His Val Ala Thr 
    50                  55                  60                  


Ala Thr Phe Arg Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr 
65                  70                  75                  80  


Tyr Ile Val Val Leu Met Glu Glu Thr Gln Arg Leu Gln Ile Glu Gln 
                85                  90                  95      


Thr Ala His Arg Leu Gln Thr Arg Ala Ala Arg Arg Gly Tyr Val Ile 
            100                 105                 110         


Lys Val Leu His Ile Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys 
        115                 120                 125             


Met Ser Ser Asp Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu 
    130                 135                 140                 


Tyr Ile Glu Glu Asp Ser Phe Val Phe Ala Gln Ser Ile Pro Trp Asn 
145                 150                 155                 160 


Leu Glu Arg Ile Ile Pro Ala Trp His Gln Thr Glu Glu Asp Arg Ser 
                165                 170                 175     


Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile 
            180                 185                 190         


Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe 
        195                 200                 205             


Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser 
    210                 215                 220                 


Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg 
225                 230                 235                 240 


Asp Ala Gly Val Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu 
                245                 250                 255     


Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu 
            260                 265                 270         


Phe Ile Arg Lys Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val 
        275                 280                 285             


Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Ile Leu Asn Ala Ala Cys 
    290                 295                 300                 


Arg His Leu Ala Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn 
305                 310                 315                 320 


Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val 
                325                 330                 335     


Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly 
            340                 345                 350         


Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly 
        355                 360                 365             


Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Met Ser 
    370                 375                 380                 


Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala 
385                 390                 395                 400 


Arg Met Leu Ser Arg Glu Pro Thr Leu Thr Leu Ala Glu Leu Arg Gln 
                405                 410                 415     


Arg Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe 
            420                 425                 430         


Pro Glu Asp Gln Gln Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro 
        435                 440                 445             


Pro Ser Thr His Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val Trp 
    450                 455                 460                 


Ser Ala His Ser Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala Arg Cys 
465                 470                 475                 480 


Ala Pro Glu Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly 
                485                 490                 495     


Arg Arg Arg Gly Asp Trp Ile Glu Ala Ile Gly Gly Gln Gln Val Cys 
            500                 505                 510         


Lys Ala Leu Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg 
        515                 520                 525             


Cys Cys Leu Val Pro Arg Ala Asn Cys Ser Ile His Asn Thr Pro Ala 
    530                 535                 540                 


Ala Arg Ala Gly Leu Glu Thr His Val His Cys His Gln Lys Asp His 
545                 550                 555                 560 


Val Leu Thr Gly Cys Ser Phe His Trp Glu Val Glu Asp Leu Ser Val 
                565                 570                 575     


Arg Arg Gln Pro Ala Leu Arg Ser Arg Arg Gln Pro Gly Gln Cys Val 
            580                 585                 590         


Gly His Gln Ala Ala Ser Val Tyr Ala Ser Cys Cys His Ala Pro Gly 
        595                 600                 605             


Leu Glu Cys Lys Ile Lys Glu His Gly Ile Ser Gly Pro Ser Glu Gln 
    610                 615                 620                 


Val Thr Val Ala Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys Asn Val 
625                 630                 635                 640 


Leu Pro Gly Ala Ser Leu Thr Leu Gly Ala Tyr Ser Val Asp Asn Leu 
                645                 650                 655     


Cys Val Ala Arg Val His Asp Thr Ala Arg Ala Asp Arg Thr Ser Gly 
            660                 665                 670         


Glu Ala Thr Val Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala 
        675                 680                 685             


Lys Ala Ser Trp Val Gln 
    690                 


<210>  39
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PCSK9 - Fragment containing the catalytic domain 
       (C-terminal domain deletion)

<400>  39

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His 
    


<210>  40
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine PCSK9 - Fragment containing the catalytic domain 
       (C-terminal domain deletion)

<400>  40

Met Gly Thr His Cys Ser Ala Trp Leu Arg Trp Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ala 
            20                  25                  30          


Gly Ala Gln Asp Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu 
        35                  40                  45              


Pro Ser Gln Glu Asp Gly Leu Ala Asp Glu Ala Ala His Val Ala Thr 
    50                  55                  60                  


Ala Thr Phe Arg Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr 
65                  70                  75                  80  


Tyr Ile Val Val Leu Met Glu Glu Thr Gln Arg Leu Gln Ile Glu Gln 
                85                  90                  95      


Thr Ala His Arg Leu Gln Thr Arg Ala Ala Arg Arg Gly Tyr Val Ile 
            100                 105                 110         


Lys Val Leu His Ile Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys 
        115                 120                 125             


Met Ser Ser Asp Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu 
    130                 135                 140                 


Tyr Ile Glu Glu Asp Ser Phe Val Phe Ala Gln Ser Ile Pro Trp Asn 
145                 150                 155                 160 


Leu Glu Arg Ile Ile Pro Ala Trp His Gln Thr Glu Glu Asp Arg Ser 
                165                 170                 175     


Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile 
            180                 185                 190         


Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe 
        195                 200                 205             


Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser 
    210                 215                 220                 


Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg 
225                 230                 235                 240 


Asp Ala Gly Val Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu 
                245                 250                 255     


Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu 
            260                 265                 270         


Phe Ile Arg Lys Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val 
        275                 280                 285             


Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Ile Leu Asn Ala Ala Cys 
    290                 295                 300                 


Arg His Leu Ala Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn 
305                 310                 315                 320 


Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val 
                325                 330                 335     


Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly 
            340                 345                 350         


Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly 
        355                 360                 365             


Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Met Ser 
    370                 375                 380                 


Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala 
385                 390                 395                 400 


Arg Met Leu Ser Arg Glu Pro Thr Leu Thr Leu Ala Glu Leu Arg Gln 
                405                 410                 415     


Arg Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe 
            420                 425                 430         


Pro Glu Asp Gln Gln Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro 
        435                 440                 445             


Pro Ser Thr His 
    450         


