                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHODS OF TREATING OR PREVENTING PRURITIS BY BLOCKING 
       NATRIURETIC POLYPEPTIDE B

<130>  718955

<150>  US 61/912,334
<151>  2013-12-05

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  1
ccccgcaggc tgagggcagg tgggaagcaa acccggacgc atcgcagcag cagcagcagc       60

agcagaagca gcagcagcag cctccgcagt ccctccagag acatggatcc ccagacagca      120

ccttcccggg cgctcctgct cctgctcttc ttgcatctgg ctttcctggg aggtcgttcc      180

cacccgctgg gcagccccgg ttcagcctcg gacttggaaa cgtccgggtt acaggagcag      240

cgcaaccatt tgcagggcaa actgtcggag ctgcaggtgg agcagacatc cctggagccc      300

ctccaggaga gcccccgtcc cacaggtgtc tggaagtccc gggaggtagc caccgagggc      360

atccgtgggc accgcaaaat ggtcctctac accctgcggg caccacgaag ccccaagatg      420

gtgcaagggt ctggctgctt tgggaggaag atggaccgga tcagctcctc cagtggcctg      480

ggctgcaaag tgctgaggcg gcattaagag gaagtcctgg ctgcagacac ctgcttctga      540

ttccacaagg ggctttttcc tcaaccctgt ggccgccttt gaagtgactc atttttttaa      600

tgtatttatg tatttatttg attgttttat ataagatggt ttcttacctt tgagcacaaa      660

atttccacgg tgaaataaag tcaacattat aagctttaaa aaaaaaaa                   708


<210>  2
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210>  3
<211>  4201
<212>  DNA
<213>  Homo sapiens

<400>  3
acactccctg gggcaggcgc tcacgcacgc tacaaacaca cactcctctt tcctccctcg       60

cgcgccctct ctcatccttc ttcacgaagc gctcactcgc accctttctc tctctctctc      120

tctctctcta acacgcacgc acactcccag ttgttcacac tcgggtcctc tccagcccga      180

cgttctcctg gcacccacct gctccgcggc gccctgcgcg cccccctcgg tcgcgcccct      240

tgcgctctcg gcccagaccg tcgcagctac agggggcctc gagccccggg gtgagcgtcc      300

ccgtcccgct cctgctcctt cccataggga cgcgcctgat gcctgggacc ggccgctgag      360

cccaagggga ccgaggaggc catggtagga gcgctcgcct gctgcggtgc ccgctgaggc      420

catgccgggg ccccggcgcc ccgctggctc ccgcctgcgc ctgctcctgc tcctgctgct      480

gccgccgctg ctgctgctgc tccggggcag ccacgcgggc aacctgacgg tagccgtggt      540

actgccgctg gccaatacct cgtacccctg gtcgtgggcg cgcgtgggac ccgccgtgga      600

gctggccctg gcccaggtga aggcgcgccc cgacttgctg ccgggctgga cggtccgcac      660

ggtgctgggc agcagcgaaa acgcgctggg cgtctgctcc gacaccgcag cgcccctggc      720

cgcggtggac ctcaagtggg agcacaaccc cgctgtgttc ctgggccccg gctgcgtgta      780

cgccgccgcc ccagtggggc gcttcaccgc gcactggcgg gtcccgctgc tgaccgccgg      840

cgccccggcg ctgggcttcg gtgtcaagga cgagtatgcg ctgaccaccc gcgcggggcc      900

cagctacgcc aagctggggg acttcgtggc ggcgctgcac cgacggctgg gctgggagcg      960

ccaagcgctc atgctctacg cctaccggcc gggtgacgaa gagcactgct tcttcctcgt     1020

ggaggggctg ttcatgcggg tccgcgaccg cctcaatatt acggtggacc acctggagtt     1080

cgccgaggac gacctcagcc actacaccag gctgctgcgg accatgccgc gcaaaggccg     1140

agttatctac atctgcagct cccctgatgc cttcagaacc ctcatgctcc tggccctgga     1200

agctggcttg tgtggggagg actacgtttt cttccacctg gatatctttg ggcaaagcct     1260

gcaaggtgga cagggccctg ctccccgcag gccctgggag agaggggatg ggcaggatgt     1320

cagtgcccgc caggcctttc aggctgccaa aatcattaca tataaagacc cagataatcc     1380

cgagtacttg gaattcctga agcagttaaa acacctggcc tatgagcagt tcaacttcac     1440

catggaggat ggcctggtga acaccatccc agcatccttc cacgacgggc tcctgctcta     1500

tatccaggca gtgacggaga ctctggcaca tgggggaact gttactgatg gggagaacat     1560

cactcagcgg atgtggaacc gaagctttca aggtgtgaca ggatacctga aaattgatag     1620

cagtggcgat cgggaaacag acttctccct ctgggatatg gatcccgaga atggtgcctt     1680

cagggttgta ctgaactaca atgggacttc ccaagagctg gtggctgtgt cggggcgcaa     1740

actgaactgg cccctggggt accctcctcc tgacatcccc aaatgtggct ttgacaacga     1800

agacccagca tgcaaccaag atcacctttc caccctggag gtgctggctt tggtgggcag     1860

cctctccttg ctcggcattc tgattgtctc cttcttcata tacaggaaga tgcagctgga     1920

gaaggaactg gcctcggagc tgtggcgggt gcgctgggag gacgttgagc ccagtagcct     1980

tgagaggcac ctgcggagtg caggcagccg gctgaccctg agcgggagag gctccaatta     2040

cggctccctg ctaaccacag agggccagtt ccaagtcttt gccaagacag catattataa     2100

gggcaacctc gtggctgtga aacgtgtgaa ccgtaaacgc attgagctga cacgaaaagt     2160

cctgtttgaa ctgaagcata tgcgggatgt gcagaatgaa cacctgacca ggtttgtggg     2220

agcctgcacc gaccccccca atatctgcat cctcacagag tactgtcccc gtgggagcct     2280

gcaggacatt ctggagaatg agagcatcac cctggactgg atgttccggt actcactcac     2340

caatgacatc gtcaagggca tgctgtttct acacaatggg gctatctgtt cccatgggaa     2400

cctcaagtca tccaactgcg tggtagatgg gcgctttgtg ctcaagatca ccgactatgg     2460

gctggagagc ttcagggacc tggacccaga gcaaggacac accgtttatg ccaaaaagct     2520

gtggacggcc cctgagctcc tgcgaatggc ttcaccccct gtgcggggct cccaggctgg     2580

tgacgtatac agctttggga tcatccttca ggagattgcc ctgaggagtg gggtcttcca     2640

cgtggaaggt ttggacctga gccccaaaga gatcatcgag cgggtgactc ggggtgagca     2700

gccccccttc cggccctccc tggccctgca gagtcacctg gaggagttgg ggctgctcat     2760

gcagcggtgc tgggctgagg acccacagga gaggccacca ttccagcaga tccgcctgac     2820

gttgcgcaaa tttaacaggg agaacagcag caacatcctg gacaacctgc tgtcccgcat     2880

ggagcagtac gcgaacaatc tggaggaact ggtggaggag cggacccagg catacctgga     2940

ggagaagcgc aaggctgagg ccctgctcta ccagatcctg cctcactcag tggctgagca     3000

gctgaagcgt ggggagacgg tgcaggccga agcctttgac agtgttacca tctacttcag     3060

tgacattgtg ggtttcacag cgctgtcggc ggagagcaca cccatgcagg tggtgaccct     3120

gctcaatgac ctgtacactt gctttgatgc tgtcatagac aactttgatg tgtacaaggt     3180

ggagacaatt ggcgatgcct acatggtggt gtcagggctc cctgtgcgga acgggcggct     3240

acacgcctgc gaggtagccc gcatggccct ggcactgctg gatgctgtgc gctccttccg     3300

aatccgccac cggccccagg agcagctgcg cttgcgcatt ggcatccaca caggacctgt     3360

gtgtgctgga gtggtgggac tgaagatgcc ccgttactgt ctctttgggg atacagtcaa     3420

cacagcctca agaatggagt ctaatgggga agccctgaag atccacttgt cttctgagac     3480

caaggctgtc ctggaggagt ttggtggttt cgagctggag cttcgagggg atgtagaaat     3540

gaagggcaaa ggcaaggttc ggacctactg gctccttggg gagaggggga gtagcacccg     3600

aggctgacct gcctcctctc ctatccctcc acacctccct accctgtgcc agaagcaaca     3660

gaggtgccag gcctcagcct cacccacagc agccccatcg ccaaaggatg gaagtaattt     3720

gaatagctca ggtgtgctga ccccagtgaa gacaccagat aggacctctg agaggggact     3780

ggcatggggg gatctcagag cttacaggct gagccaagcc cacggccatg cacagggaca     3840

ctcacacagg cacacgcacc tgctctccac ctggactcag gccgggctgg gctgtggatt     3900

cctgatcccc tcccctcccc atgctctcct ccctcagcct tgctaccctg tgacttactg     3960

ggaggagaaa gagtcacctg aaggggaaca tgaaaagaga ctaggtgaag agagggcagg     4020

ggagcccaca tctggggctg gcccacaata cctgctcccc cgaccccctc cacccagcag     4080

tagacacagt gcacagggga gaagaggggt ggcgcagaag ggttgggggc ctgtatgcct     4140

tgcttctacc atgagcagag acaattaaaa tctttattcc agtgaaaaaa aaaaaaaaaa     4200

a                                                                     4201


<210>  4
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Gly Pro Arg Arg Pro Ala Gly Ser Arg Leu Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Leu Arg Gly Ser His Ala 
            20                  25                  30          


Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu Ala Asn Thr Ser Tyr 
        35                  40                  45              


Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala 
    50                  55                  60                  


Gln Val Lys Ala Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Thr 
65                  70                  75                  80  


Val Leu Gly Ser Ser Glu Asn Ala Leu Gly Val Cys Ser Asp Thr Ala 
                85                  90                  95      


Ala Pro Leu Ala Ala Val Asp Leu Lys Trp Glu His Asn Pro Ala Val 
            100                 105                 110         


Phe Leu Gly Pro Gly Cys Val Tyr Ala Ala Ala Pro Val Gly Arg Phe 
        115                 120                 125             


Thr Ala His Trp Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu 
    130                 135                 140                 


Gly Phe Gly Val Lys Asp Glu Tyr Ala Leu Thr Thr Arg Ala Gly Pro 
145                 150                 155                 160 


Ser Tyr Ala Lys Leu Gly Asp Phe Val Ala Ala Leu His Arg Arg Leu 
                165                 170                 175     


Gly Trp Glu Arg Gln Ala Leu Met Leu Tyr Ala Tyr Arg Pro Gly Asp 
            180                 185                 190         


Glu Glu His Cys Phe Phe Leu Val Glu Gly Leu Phe Met Arg Val Arg 
        195                 200                 205             


Asp Arg Leu Asn Ile Thr Val Asp His Leu Glu Phe Ala Glu Asp Asp 
    210                 215                 220                 


Leu Ser His Tyr Thr Arg Leu Leu Arg Thr Met Pro Arg Lys Gly Arg 
225                 230                 235                 240 


Val Ile Tyr Ile Cys Ser Ser Pro Asp Ala Phe Arg Thr Leu Met Leu 
                245                 250                 255     


Leu Ala Leu Glu Ala Gly Leu Cys Gly Glu Asp Tyr Val Phe Phe His 
            260                 265                 270         


Leu Asp Ile Phe Gly Gln Ser Leu Gln Gly Gly Gln Gly Pro Ala Pro 
        275                 280                 285             


Arg Arg Pro Trp Glu Arg Gly Asp Gly Gln Asp Val Ser Ala Arg Gln 
    290                 295                 300                 


Ala Phe Gln Ala Ala Lys Ile Ile Thr Tyr Lys Asp Pro Asp Asn Pro 
305                 310                 315                 320 


Glu Tyr Leu Glu Phe Leu Lys Gln Leu Lys His Leu Ala Tyr Glu Gln 
                325                 330                 335     


Phe Asn Phe Thr Met Glu Asp Gly Leu Val Asn Thr Ile Pro Ala Ser 
            340                 345                 350         


Phe His Asp Gly Leu Leu Leu Tyr Ile Gln Ala Val Thr Glu Thr Leu 
        355                 360                 365             


Ala His Gly Gly Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met 
    370                 375                 380                 


Trp Asn Arg Ser Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Ser 
385                 390                 395                 400 


Ser Gly Asp Arg Glu Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu 
                405                 410                 415     


Asn Gly Ala Phe Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu 
            420                 425                 430         


Leu Val Ala Val Ser Gly Arg Lys Leu Asn Trp Pro Leu Gly Tyr Pro 
        435                 440                 445             


Pro Pro Asp Ile Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys 
    450                 455                 460                 


Asn Gln Asp His Leu Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser 
465                 470                 475                 480 


Leu Ser Leu Leu Gly Ile Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys 
                485                 490                 495     


Met Gln Leu Glu Lys Glu Leu Ala Ser Glu Leu Trp Arg Val Arg Trp 
            500                 505                 510         


Glu Asp Val Glu Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly 
        515                 520                 525             


Ser Arg Leu Thr Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu 
    530                 535                 540                 


Thr Thr Glu Gly Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys 
545                 550                 555                 560 


Gly Asn Leu Val Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu 
                565                 570                 575     


Thr Arg Lys Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn 
            580                 585                 590         


Glu His Leu Thr Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile 
        595                 600                 605             


Cys Ile Leu Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
    610                 615                 620                 


Glu Asn Glu Ser Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr 
625                 630                 635                 640 


Asn Asp Ile Val Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Cys 
                645                 650                 655     


Ser His Gly Asn Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe 
            660                 665                 670         


Val Leu Lys Ile Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Leu Asp 
        675                 680                 685             


Pro Glu Gln Gly His Thr Val Tyr Ala Lys Lys Leu Trp Thr Ala Pro 
    690                 695                 700                 


Glu Leu Leu Arg Met Ala Ser Pro Pro Val Arg Gly Ser Gln Ala Gly 
705                 710                 715                 720 


Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser 
                725                 730                 735     


Gly Val Phe His Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile 
            740                 745                 750         


Glu Arg Val Thr Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Leu Ala 
        755                 760                 765             


Leu Gln Ser His Leu Glu Glu Leu Gly Leu Leu Met Gln Arg Cys Trp 
    770                 775                 780                 


Ala Glu Asp Pro Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Thr 
785                 790                 795                 800 


Leu Arg Lys Phe Asn Arg Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu 
                805                 810                 815     


Leu Ser Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu 
            820                 825                 830         


Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu 
        835                 840                 845             


Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly 
    850                 855                 860                 


Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser 
865                 870                 875                 880 


Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln 
                885                 890                 895     


Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile 
            900                 905                 910         


Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met 
        915                 920                 925             


Val Val Ser Gly Leu Pro Val Arg Asn Gly Arg Leu His Ala Cys Glu 
    930                 935                 940                 


Val Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg 
945                 950                 955                 960 


Ile Arg His Arg Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His 
                965                 970                 975     


Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr 
            980                 985                 990         


Cys Leu Phe Gly Asp Thr Val Asn  Thr Ala Ser Arg Met  Glu Ser Asn 
        995                 1000                 1005             


Gly Glu  Ala Leu Lys Ile His  Leu Ser Ser Glu Thr  Lys Ala Val 
    1010                 1015                 1020             


Leu Glu  Glu Phe Gly Gly Phe  Glu Leu Glu Leu Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Met  Lys Gly Lys Gly Lys  Val Arg Thr Tyr Trp  Leu Leu Gly 
    1040                 1045                 1050             


Glu Arg  Gly Ser Ser Thr Arg  Gly 
    1055                 1060     


<210>  5
<211>  4178
<212>  DNA
<213>  Homo sapiens

<400>  5
gcttggctcg ggtcctccac ggttccctcc ggatagccgg agacttgggc cggccggacg       60

ccccttctgg cacactccct ggggcaggcg ctcacgcacg ctacaaacac acactcctct      120

ttcctccctc gcgcgccctc tctcatcctt cttcacgaag cgctcactcg caccctttct      180

ctctctctct ctctctctct aacacgcacg cacactccca gttgttcaca ctcgggtcct      240

ctccagcccg acgttctcct ggcacccacc tgctccgcgg cgccctgcgc gcccccctcg      300

gtcgcgcccc ttgcgctctc ggcccagacc gtcgcagcta cagggggcct cgagccccgg      360

ggtgagcgtc cccgtcccgc tcctgctcct tcccataggg acgcgcctga tgcctgggac      420

cggccgctga gcccaagggg accgaggagg ccatggtagg agcgctcgcc tgctgcggtg      480

cccgctgagg ccatgccggg gccccggcgc cccgctggct cccgcctgcg cctgctcctg      540

ctcctgctgc tgccgccgct gctgctgctg ctccggggca gccacgcggg caacctgacg      600

gtagccgtgg tactgccgct ggccaatacc tcgtacccct ggtcgtgggc gcgcgtggga      660

cccgccgtgg agctggccct ggcccaggtg aaggcgcgcc ccgacttgct gccgggctgg      720

acggtccgca cggtgctggg cagcagcgaa aacgcgctgg gcgtctgctc cgacaccgca      780

gcgcccctgg ccgcggtgga cctcaagtgg gagcacaacc ccgctgtgtt cctgggcccc      840

ggctgcgtgt acgccgccgc cccagtgggg cgcttcaccg cgcactggcg ggtcccgctg      900

ctgaccgccg gcgccccggc gctgggcttc ggtgtcaagg acgagtatgc gctgaccacc      960

cgcgcggggc ccagctacgc caagctgggg gacttcgtgg cggcgctgca ccgacggctg     1020

ggctgggagc gccaagcgct catgctctac gcctaccggc cgggtgacga agagcactgc     1080

ttcttcctcg tggaggggct gttcatgcgg gtccgcgacc gcctcaatat tacggtggac     1140

cacctggagt tcgccgagga cgacctcagc cactacacca ggctgctgcg gaccatgccg     1200

cgcaaaggcc gagttatcta catctgcagc tcccctgatg ccttcagaac cctcatgctc     1260

ctggccctgg aagctggctt gtgtggggag gactacgttt tcttccacct ggatatcttt     1320

gggcaaagcc tgcaaggtgg acagggccct gctccccgca ggccctggga gagaggggat     1380

gggcaggatg tcagtgcccg ccaggccttt caggctgcca aaatcattac atataaagac     1440

ccagataatc ccgagtactt ggaattcctg aagcagttaa aacacctggc ctatgagcag     1500

ttcaacttca ccatggagga tggcctggtg aacaccatcc cagcatcctt ccacgacggg     1560

ctcctgctct atatccaggc agtgacggag actctggcac atgggggaac tgttactgat     1620

ggggagaaca tcactcagcg gatgtggaac cgaagctttc aaggtgtgac aggatacctg     1680

aaaattgata gcagtggcga tcgggaaaca gacttctccc tctgggatat ggatcccgag     1740

aatggtgcct tcagggttgt actgaactac aatgggactt cccaagagct ggtggctgtg     1800

tcggggcgca aactgaactg gcccctgggg taccctcctc ctgacatccc caaatgtggc     1860

tttgacaacg aagacccagc atgcaaccaa gatcaccttt ccaccctgga ggtgctggct     1920

ttggtgggca gcctctcctt gctcggcatt ctgattgtct ccttcttcat atacaggaag     1980

atgcagctgg agaaggaact ggcctcggag ctgtggcggg tgcgctggga ggacgttgag     2040

cccagtagcc ttgagaggca cctgcggagt gcaggcagcc ggctgaccct gagcgggaga     2100

ggctccaatt acggctccct gctaaccaca gagggccagt tccaagtctt tgccaagaca     2160

gcatattata agatgcggga tgtgcagaat gaacacctga ccaggtttgt gggagcctgc     2220

accgaccccc ccaatatctg catcctcaca gagtactgtc cccgtgggag cctgcaggac     2280

attctggaga atgagagcat caccctggac tggatgttcc ggtactcact caccaatgac     2340

atcgtcaagg gcatgctgtt tctacacaat ggggctatct gttcccatgg gaacctcaag     2400

tcatccaact gcgtggtaga tgggcgcttt gtgctcaaga tcaccgacta tgggctggag     2460

agcttcaggg acctggaccc agagcaagga cacaccgttt atgccaaaaa gctgtggacg     2520

gcccctgagc tcctgcgaat ggcttcaccc cctgtgcggg gctcccaggc tggtgacgta     2580

tacagctttg ggatcatcct tcaggagatt gccctgagga gtggggtctt ccacgtggaa     2640

ggtttggacc tgagccccaa agagatcatc gagcgggtga ctcggggtga gcagcccccc     2700

ttccggccct ccctggccct gcagagtcac ctggaggagt tggggctgct catgcagcgg     2760

tgctgggctg aggacccaca ggagaggcca ccattccagc agatccgcct gacgttgcgc     2820

aaatttaaca gggagaacag cagcaacatc ctggacaacc tgctgtcccg catggagcag     2880

tacgcgaaca atctggagga actggtggag gagcggaccc aggcatacct ggaggagaag     2940

cgcaaggctg aggccctgct ctaccagatc ctgcctcact cagtggctga gcagctgaag     3000

cgtggggaga cggtgcaggc cgaagccttt gacagtgtta ccatctactt cagtgacatt     3060

gtgggtttca cagcgctgtc ggcggagagc acacccatgc aggtggtgac cctgctcaat     3120

gacctgtaca cttgctttga tgctgtcata gacaactttg atgtgtacaa ggtggagaca     3180

attggcgatg cctacatggt ggtgtcaggg ctccctgtgc ggaacgggcg gctacacgcc     3240

tgcgaggtag cccgcatggc cctggcactg ctggatgctg tgcgctcctt ccgaatccgc     3300

caccggcccc aggagcagct gcgcttgcgc attggcatcc acacaggacc tgtgtgtgct     3360

ggagtggtgg gactgaagat gccccgttac tgtctctttg gggatacagt caacacagcc     3420

tcaagaatgg agtctaatgg ggaagccctg aagatccact tgtcttctga gaccaaggct     3480

gtcctggagg agtttggtgg tttcgagctg gagcttcgag gggatgtaga aatgaagggc     3540

aaaggcaagg ttcggaccta ctggctcctt ggggagaggg ggagtagcac ccgaggctga     3600

cctgcctcct ctcctatccc tccacacctc cctaccctgt gccagaagca acagaggtgc     3660

caggcctcag cctcacccac agcagcccca tcgccaaagg atggaagtaa tttgaatagc     3720

tcaggtgtgc tgaccccagt gaagacacca gataggacct ctgagagggg actggcatgg     3780

ggggatctca gagcttacag gctgagccaa gcccacggcc atgcacaggg acactcacac     3840

aggcacacgc acctgctctc cacctggact caggccgggc tgggctgtgg attcctgatc     3900

ccctcccctc cccatgctct cctccctcag ccttgctacc ctgtgactta ctgggaggag     3960

aaagagtcac ctgaagggga acatgaaaag agactaggtg aagagagggc aggggagccc     4020

acatctgggg ctggcccaca atacctgctc ccccgacccc ctccacccag cagtagacac     4080

agtgcacagg ggagaagagg ggtggcgcag aagggttggg ggcctgtatg ccttgcttct     4140

accatgagca gagacaatta aaatctttat tccagtga                             4178


<210>  6
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Gly Pro Arg Arg Pro Ala Gly Ser Arg Leu Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Leu Arg Gly Ser His Ala 
            20                  25                  30          


Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu Ala Asn Thr Ser Tyr 
        35                  40                  45              


Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala 
    50                  55                  60                  


Gln Val Lys Ala Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Thr 
65                  70                  75                  80  


Val Leu Gly Ser Ser Glu Asn Ala Leu Gly Val Cys Ser Asp Thr Ala 
                85                  90                  95      


Ala Pro Leu Ala Ala Val Asp Leu Lys Trp Glu His Asn Pro Ala Val 
            100                 105                 110         


Phe Leu Gly Pro Gly Cys Val Tyr Ala Ala Ala Pro Val Gly Arg Phe 
        115                 120                 125             


Thr Ala His Trp Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu 
    130                 135                 140                 


Gly Phe Gly Val Lys Asp Glu Tyr Ala Leu Thr Thr Arg Ala Gly Pro 
145                 150                 155                 160 


Ser Tyr Ala Lys Leu Gly Asp Phe Val Ala Ala Leu His Arg Arg Leu 
                165                 170                 175     


Gly Trp Glu Arg Gln Ala Leu Met Leu Tyr Ala Tyr Arg Pro Gly Asp 
            180                 185                 190         


Glu Glu His Cys Phe Phe Leu Val Glu Gly Leu Phe Met Arg Val Arg 
        195                 200                 205             


Asp Arg Leu Asn Ile Thr Val Asp His Leu Glu Phe Ala Glu Asp Asp 
    210                 215                 220                 


Leu Ser His Tyr Thr Arg Leu Leu Arg Thr Met Pro Arg Lys Gly Arg 
225                 230                 235                 240 


Val Ile Tyr Ile Cys Ser Ser Pro Asp Ala Phe Arg Thr Leu Met Leu 
                245                 250                 255     


Leu Ala Leu Glu Ala Gly Leu Cys Gly Glu Asp Tyr Val Phe Phe His 
            260                 265                 270         


Leu Asp Ile Phe Gly Gln Ser Leu Gln Gly Gly Gln Gly Pro Ala Pro 
        275                 280                 285             


Arg Arg Pro Trp Glu Arg Gly Asp Gly Gln Asp Val Ser Ala Arg Gln 
    290                 295                 300                 


Ala Phe Gln Ala Ala Lys Ile Ile Thr Tyr Lys Asp Pro Asp Asn Pro 
305                 310                 315                 320 


Glu Tyr Leu Glu Phe Leu Lys Gln Leu Lys His Leu Ala Tyr Glu Gln 
                325                 330                 335     


Phe Asn Phe Thr Met Glu Asp Gly Leu Val Asn Thr Ile Pro Ala Ser 
            340                 345                 350         


Phe His Asp Gly Leu Leu Leu Tyr Ile Gln Ala Val Thr Glu Thr Leu 
        355                 360                 365             


Ala His Gly Gly Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met 
    370                 375                 380                 


Trp Asn Arg Ser Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Ser 
385                 390                 395                 400 


Ser Gly Asp Arg Glu Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu 
                405                 410                 415     


Asn Gly Ala Phe Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu 
            420                 425                 430         


Leu Val Ala Val Ser Gly Arg Lys Leu Asn Trp Pro Leu Gly Tyr Pro 
        435                 440                 445             


Pro Pro Asp Ile Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys 
    450                 455                 460                 


Asn Gln Asp His Leu Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser 
465                 470                 475                 480 


Leu Ser Leu Leu Gly Ile Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys 
                485                 490                 495     


Met Gln Leu Glu Lys Glu Leu Ala Ser Glu Leu Trp Arg Val Arg Trp 
            500                 505                 510         


Glu Asp Val Glu Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly 
        515                 520                 525             


Ser Arg Leu Thr Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu 
    530                 535                 540                 


Thr Thr Glu Gly Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys 
545                 550                 555                 560 


Met Arg Asp Val Gln Asn Glu His Leu Thr Arg Phe Val Gly Ala Cys 
                565                 570                 575     


Thr Asp Pro Pro Asn Ile Cys Ile Leu Thr Glu Tyr Cys Pro Arg Gly 
            580                 585                 590         


Ser Leu Gln Asp Ile Leu Glu Asn Glu Ser Ile Thr Leu Asp Trp Met 
        595                 600                 605             


Phe Arg Tyr Ser Leu Thr Asn Asp Ile Val Lys Gly Met Leu Phe Leu 
    610                 615                 620                 


His Asn Gly Ala Ile Cys Ser His Gly Asn Leu Lys Ser Ser Asn Cys 
625                 630                 635                 640 


Val Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp Tyr Gly Leu Glu 
                645                 650                 655     


Ser Phe Arg Asp Leu Asp Pro Glu Gln Gly His Thr Val Tyr Ala Lys 
            660                 665                 670         


Lys Leu Trp Thr Ala Pro Glu Leu Leu Arg Met Ala Ser Pro Pro Val 
        675                 680                 685             


Arg Gly Ser Gln Ala Gly Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln 
    690                 695                 700                 


Glu Ile Ala Leu Arg Ser Gly Val Phe His Val Glu Gly Leu Asp Leu 
705                 710                 715                 720 


Ser Pro Lys Glu Ile Ile Glu Arg Val Thr Arg Gly Glu Gln Pro Pro 
                725                 730                 735     


Phe Arg Pro Ser Leu Ala Leu Gln Ser His Leu Glu Glu Leu Gly Leu 
            740                 745                 750         


Leu Met Gln Arg Cys Trp Ala Glu Asp Pro Gln Glu Arg Pro Pro Phe 
        755                 760                 765             


Gln Gln Ile Arg Leu Thr Leu Arg Lys Phe Asn Arg Glu Asn Ser Ser 
    770                 775                 780                 


Asn Ile Leu Asp Asn Leu Leu Ser Arg Met Glu Gln Tyr Ala Asn Asn 
785                 790                 795                 800 


Leu Glu Glu Leu Val Glu Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys 
                805                 810                 815     


Arg Lys Ala Glu Ala Leu Leu Tyr Gln Ile Leu Pro His Ser Val Ala 
            820                 825                 830         


Glu Gln Leu Lys Arg Gly Glu Thr Val Gln Ala Glu Ala Phe Asp Ser 
        835                 840                 845             


Val Thr Ile Tyr Phe Ser Asp Ile Val Gly Phe Thr Ala Leu Ser Ala 
    850                 855                 860                 


Glu Ser Thr Pro Met Gln Val Val Thr Leu Leu Asn Asp Leu Tyr Thr 
865                 870                 875                 880 


Cys Phe Asp Ala Val Ile Asp Asn Phe Asp Val Tyr Lys Val Glu Thr 
                885                 890                 895     


Ile Gly Asp Ala Tyr Met Val Val Ser Gly Leu Pro Val Arg Asn Gly 
            900                 905                 910         


Arg Leu His Ala Cys Glu Val Ala Arg Met Ala Leu Ala Leu Leu Asp 
        915                 920                 925             


Ala Val Arg Ser Phe Arg Ile Arg His Arg Pro Gln Glu Gln Leu Arg 
    930                 935                 940                 


Leu Arg Ile Gly Ile His Thr Gly Pro Val Cys Ala Gly Val Val Gly 
945                 950                 955                 960 


Leu Lys Met Pro Arg Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala 
                965                 970                 975     


Ser Arg Met Glu Ser Asn Gly Glu Ala Leu Lys Ile His Leu Ser Ser 
            980                 985                 990         


Glu Thr Lys Ala Val Leu Glu Glu  Phe Gly Gly Phe Glu  Leu Glu Leu 
        995                 1000                 1005             


Arg Gly  Asp Val Glu Met Lys  Gly Lys Gly Lys Val  Arg Thr Tyr 
    1010                 1015                 1020             


Trp Leu  Leu Gly Glu Arg Gly  Ser Ser Thr Arg Gly  
    1025                 1030                 1035 


<210>  7
<211>  797
<212>  DNA
<213>  Mus musculus

<400>  7
ccggcaggaa tgcagctgat aaatcagaga taaccccacc cctactccgt gaaaaggtct       60

ggccggacac tcagccccag tataaaaggc agaggcaccg ttgttgaaga caccagtgca      120

caagctgctt ggggaggcga gacaagggag aacacggcat cattgcctgg cccatcgctt      180

ctgcggcatg gatctcctga aggtgctgtc ccagatgatt ctgtttctgc ttttccttta      240

tctgtcaccg ctgggaggtc actcctatcc tctgggaagt cctagccagt ctccagagca      300

attcaagatg cagaagctgc tggagctgat aagagaaaag tcggaggaaa tggcccagag      360

acagctcttg aaggaccaag gcctcacaaa agaacaccca aaaagagtcc ttcggtctca      420

aggcagcacc ctccgggtcc agcagagacc tcaaaattcc aaggtgacac atatctcaag      480

ctgctttggg cacaagatag accggatcgg atccgtcagt cgtttgggct gtaacgcact      540

gaagttgttg taggaagacc tcctggctgc aggagactcc agtttctgac tctgcctggg      600

tctctttccc cagctctggg accacctttg aagtgatcct atttatttat ttatttatat      660

ttatttttat ttttattttt taatttattt tgttgttttt ctacaagact gtttcttatc      720

ttggagcaca aacttgccac aacataataa acatagcgta tttcctgctt ttgaaaagga      780

aaaaaaaaaa aaaaaaa                                                     797


<210>  8
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  8

Met Asp Leu Leu Lys Val Leu Ser Gln Met Ile Leu Phe Leu Leu Phe 
1               5                   10                  15      


Leu Tyr Leu Ser Pro Leu Gly Gly His Ser Tyr Pro Leu Gly Ser Pro 
            20                  25                  30          


Ser Gln Ser Pro Glu Gln Phe Lys Met Gln Lys Leu Leu Glu Leu Ile 
        35                  40                  45              


Arg Glu Lys Ser Glu Glu Met Ala Gln Arg Gln Leu Leu Lys Asp Gln 
    50                  55                  60                  


Gly Leu Thr Lys Glu His Pro Lys Arg Val Leu Arg Ser Gln Gly Ser 
65                  70                  75                  80  


Thr Leu Arg Val Gln Gln Arg Pro Gln Asn Ser Lys Val Thr His Ile 
                85                  90                  95      


Ser Ser Cys Phe Gly His Lys Ile Asp Arg Ile Gly Ser Val Ser Arg 
            100                 105                 110         


Leu Gly Cys Asn Ala Leu Lys Leu Leu 
        115                 120     


<210>  9
<211>  4065
<212>  DNA
<213>  Mus musculus

<400>  9
atactcctgg ggcaagcgcg agcgcacact cccctttcct cgctggcgca cccgctcccc       60

tcgctcttct tagatcgccc tctcgttctc tcgctctcca cggactccct tcgggtgctg      120

cgctcgctct cacctgctct aaagcaccct ccgctctcgg acgctcccaa ttccgcgctc      180

ctgctcgacg gcgggacagt cgcagcctcg gcaggcagct tgctctcgcc gctgcggctt      240

caacccagcc ccctccctcg ctacggctcg ggcgctcttg actcccgacc ctcgcctctg      300

agcccgagga cggcgatcag accatggtga cagcgctgct ccgtcgctgc gctcgctgag      360

gccatgccgg gttcccgacg cgtccgtccg cgcctaaggg cgctgctgct gctaccgccg      420

ctgctgctgc tccgaagcgg ccacgcgagc gacctgaccg tggccgtggt gctgccgctg      480

accaacacct cgtacccgtg gtcttgggcg cgtgtagggc cggcggtgga actggctctc      540

gggagggtga aggctcggcc ggacttgctg ccgggttgga cggtccgtat ggtgctgggc      600

agcagcgaga acgcggcggg cgtctgctcc gacaccgctg caccgctggc cgcggtggat      660

ctcaagtggg agcacagccc cgcggtgttc ctgggccccg gctgcgtata ctctgctgcc      720

ccggtgggac gcttcaccgc gcactggcgg gtgccgctgc tgacggctgg cgccccggct      780

ctgggcatcg gggtgaagga tgagtacgcg ttaaccaccc gcacaggacc cagccatgtc      840

aagctgggcg acttcgtgac ggcgctgcat cgacggctgg gctgggagca ccaggcgctt      900

gtgctctatg cagatcggct gggcgacgac cggccgtgct tcttcatagt ggaggggctg      960

tacatgcggg tgcgtgagcg actcaacatc acagtaaatc accaggagtt cgtcgagggc     1020

gacccggacc actacaccaa gctactgcgg accgtgcagc gcaagggcag agttatctac     1080

atctgcagtt ctccggatgc cttcaggaat ctgatgcttt tggccctgga tgctggcctg     1140

actggggagg actatgtttt cttccacctg gatgtgtttg ggcaaagcct tcagggtgct     1200

cagggccctg ttcccaggaa gccctgggaa agagacgatg ggcaggatag gagagcccgc     1260

caggcctttc aggctgccaa aattattact tacaaagaac ccgataatcc tgagtacttg     1320

gaattcctga agcagctaaa actcttggct gacaagaaat tcaacttcac catggaggat     1380

ggcctgaaaa atatcatccc agcatccttc catgacgggc tcctgctcta tgtccaggca     1440

gtgacagaga ctctggcaca ggggggcact gtcactgatg gagagaacat cactcagcgg     1500

atgtggaacc gaagcttcca aggtgtgaca ggatacctga aaattgatag aaatggagat     1560

cgggacactg atttctccct ctgggatatg gaccccgaga caggtgcctt cagggttgtc     1620

ctgaacttta atggtacttc ccaggagctg atggctgtgt cagaacacag attatactgg     1680

cctctgggat acccacctcc tgacatccct aaatgtggct ttgacaatga ggacccagcc     1740

tgcaaccaag accacttttc cacactggag gttctggctt tggtgggcag cctctctctg     1800

gttagctttc tgatcgtgtc tttcttcata tacaggaaga tgcagctgga aaaggagctg     1860

gtctcagagt tgtggcgggt gcgctgggag gacttgcagc ccagcagcct ggagaggcac     1920

cttcggagcg ctggcagtcg gctgaccctg agtgggcgag gctccaatta tggctccctg     1980

ctaaccacgg agggccagtt ccaagtcttt gccaagacag catactataa gggcaacctc     2040

gtggctgtga aacgtgtgaa ccggaaacgc attgagttga cacgaaaagt cctgtttgaa     2100

cttaaacata tgcgggatgt gcagaatgag cacttgacca gatttgtggg agcttgtacc     2160

gaccctccca acatctgtat cctcacagag tactgtcccc gtgggagcct acaggacatt     2220

ctagagaatg agagtattac cctggactgg atgtttcggt actcactcac caatgacatt     2280

gtcaagggaa tgctctttct acacaacggg gccattggtt cccatgggaa cctcaagtca     2340

tccaactgcg tggtagatgg acgttttgtg ttaaagatca cagactatgg gctcgagagc     2400

ttcagagacc cggagccaga gcaaggacac accctctttg ccaaaaaact gtggactgca     2460

cctgagctcc tgcgaatggc ttccccacct gcccgtggct cccaagctgg ggatgtctac     2520

agttttggta tcatccttca ggaaattgcc ctaagaagtg gggtcttcta tgtggaaggt     2580

ttggacctca gcccaaaaga gatcattgag cgtgtgactc ggggcgagca gcccccattc     2640

cgaccttcca tggatctgca gagccacctg gaggaactgg ggcagctgat gcagaggtgc     2700

tgggcagagg atcctcagga gcggccaccc tttcaacaga tccgcctggc gctgcgcaag     2760

ttcaacaagg agaacagcag caacatcctg gacaacctgc tgtcacgcat ggaacagtac     2820

gccaacaacc tggaggaact ggtagaggag agaacacagg cttatctgga ggagaagcgc     2880

aaagctgagg ccctgcttta ccagattctg cctcactctg tggctgagca gctgaagaga     2940

ggcgagacag tccaggctga ggcatttgat agtgttacta tctatttcag tgatatcgtg     3000

ggctttacag ctctttcagc agagagcaca cccatgcagg tggtcaccct gctcaatgat     3060

ctgtacacct gttttgatgc tgtcatagac aactttgatg tgtacaaggt agagaccatt     3120

ggtgatgctt acatggtggt atcagggctc ccagtgagga atggacagct ccatgcccga     3180

gaggtagccc gaatggcact tgcactgctc gatgctgtac gctccttccg catccgccat     3240

aggccccagg aacagctgcg cttgcgcatt ggaattcaca caggtcccgt gtgtgctggt     3300

gtggtagggc taaagatgcc ccgatactgc ctctttggag acacagtcaa cacagcttca     3360

agaatggagt ctaatgggga agccctcagg atccacttgt cttcggagac caaggctgtg     3420

ctggaagagt tcgatggttt tgagctggag ctccgaggtg acgtggaaat gaagggcaaa     3480

ggcaaggttc gaacctattg gctcctcggg gagcggggat gcagcactcg aggctgacct     3540

actgccctgc tattccttgt cacctcccct ccctgtgcca gcaatgacac gggtgtccaa     3600

cttccgcctc tcccacagca gctcagccac tgtggaaaga ttagggacct aaccagcgca     3660

gtcatcagat gtgacctctg agagaggatg gagatggtgg ggactggagg gggactccta     3720

agtttatagg gctgactgaa atacccagtc actcccgtag cacatgcccc gccccccccc     3780

cgccccccca ctcagctgcc tagcagacag tgattccttc tgccgccctc aacttagctc     3840

cactgtgact tagagggagg gaaattgcca cctgaaggaa agagaaaaga gattctcggg     3900

gtttgcagga ggcaggcagt cctgtgtcac aaatactccc ctcactccca gtccaccacc     3960

tgccccaccg acttcccttc ccacacagtg cactgaggag aagagaggca tggggttgcc     4020

ttgcttctcc tatgagcaaa acccattaaa gtctttattc ctgtg                     4065


<210>  10
<211>  1057
<212>  PRT
<213>  Mus musculus

<400>  10

Met Pro Gly Ser Arg Arg Val Arg Pro Arg Leu Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Pro Pro Leu Leu Leu Leu Arg Ser Gly His Ala Ser Asp Leu Thr 
            20                  25                  30          


Val Ala Val Val Leu Pro Leu Thr Asn Thr Ser Tyr Pro Trp Ser Trp 
        35                  40                  45              


Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Gly Arg Val Lys Ala 
    50                  55                  60                  


Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Met Val Leu Gly Ser 
65                  70                  75                  80  


Ser Glu Asn Ala Ala Gly Val Cys Ser Asp Thr Ala Ala Pro Leu Ala 
                85                  90                  95      


Ala Val Asp Leu Lys Trp Glu His Ser Pro Ala Val Phe Leu Gly Pro 
            100                 105                 110         


Gly Cys Val Tyr Ser Ala Ala Pro Val Gly Arg Phe Thr Ala His Trp 
        115                 120                 125             


Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu Gly Ile Gly Val 
    130                 135                 140                 


Lys Asp Glu Tyr Ala Leu Thr Thr Arg Thr Gly Pro Ser His Val Lys 
145                 150                 155                 160 


Leu Gly Asp Phe Val Thr Ala Leu His Arg Arg Leu Gly Trp Glu His 
                165                 170                 175     


Gln Ala Leu Val Leu Tyr Ala Asp Arg Leu Gly Asp Asp Arg Pro Cys 
            180                 185                 190         


Phe Phe Ile Val Glu Gly Leu Tyr Met Arg Val Arg Glu Arg Leu Asn 
        195                 200                 205             


Ile Thr Val Asn His Gln Glu Phe Val Glu Gly Asp Pro Asp His Tyr 
    210                 215                 220                 


Thr Lys Leu Leu Arg Thr Val Gln Arg Lys Gly Arg Val Ile Tyr Ile 
225                 230                 235                 240 


Cys Ser Ser Pro Asp Ala Phe Arg Asn Leu Met Leu Leu Ala Leu Asp 
                245                 250                 255     


Ala Gly Leu Thr Gly Glu Asp Tyr Val Phe Phe His Leu Asp Val Phe 
            260                 265                 270         


Gly Gln Ser Leu Gln Gly Ala Gln Gly Pro Val Pro Arg Lys Pro Trp 
        275                 280                 285             


Glu Arg Asp Asp Gly Gln Asp Arg Arg Ala Arg Gln Ala Phe Gln Ala 
    290                 295                 300                 


Ala Lys Ile Ile Thr Tyr Lys Glu Pro Asp Asn Pro Glu Tyr Leu Glu 
305                 310                 315                 320 


Phe Leu Lys Gln Leu Lys Leu Leu Ala Asp Lys Lys Phe Asn Phe Thr 
                325                 330                 335     


Met Glu Asp Gly Leu Lys Asn Ile Ile Pro Ala Ser Phe His Asp Gly 
            340                 345                 350         


Leu Leu Leu Tyr Val Gln Ala Val Thr Glu Thr Leu Ala Gln Gly Gly 
        355                 360                 365             


Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met Trp Asn Arg Ser 
    370                 375                 380                 


Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Arg Asn Gly Asp Arg 
385                 390                 395                 400 


Asp Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu Thr Gly Ala Phe 
                405                 410                 415     


Arg Val Val Leu Asn Phe Asn Gly Thr Ser Gln Glu Leu Met Ala Val 
            420                 425                 430         


Ser Glu His Arg Leu Tyr Trp Pro Leu Gly Tyr Pro Pro Pro Asp Ile 
        435                 440                 445             


Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys Asn Gln Asp His 
    450                 455                 460                 


Phe Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser Leu Ser Leu Val 
465                 470                 475                 480 


Ser Phe Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys Met Gln Leu Glu 
                485                 490                 495     


Lys Glu Leu Val Ser Glu Leu Trp Arg Val Arg Trp Glu Asp Leu Gln 
            500                 505                 510         


Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly Ser Arg Leu Thr 
        515                 520                 525             


Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu Thr Thr Glu Gly 
    530                 535                 540                 


Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys Gly Asn Leu Val 
545                 550                 555                 560 


Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu Thr Arg Lys Val 
                565                 570                 575     


Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn Glu His Leu Thr 
            580                 585                 590         


Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile Cys Ile Leu Thr 
        595                 600                 605             


Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu Glu Asn Glu Ser 
    610                 615                 620                 


Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr Asn Asp Ile Val 
625                 630                 635                 640 


Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Gly Ser His Gly Asn 
                645                 650                 655     


Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe Val Leu Lys Ile 
            660                 665                 670         


Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Pro Glu Pro Glu Gln Gly 
        675                 680                 685             


His Thr Leu Phe Ala Lys Lys Leu Trp Thr Ala Pro Glu Leu Leu Arg 
    690                 695                 700                 


Met Ala Ser Pro Pro Ala Arg Gly Ser Gln Ala Gly Asp Val Tyr Ser 
705                 710                 715                 720 


Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser Gly Val Phe Tyr 
                725                 730                 735     


Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile Glu Arg Val Thr 
            740                 745                 750         


Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Met Asp Leu Gln Ser His 
        755                 760                 765             


Leu Glu Glu Leu Gly Gln Leu Met Gln Arg Cys Trp Ala Glu Asp Pro 
    770                 775                 780                 


Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Ala Leu Arg Lys Phe 
785                 790                 795                 800 


Asn Lys Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu Leu Ser Arg Met 
                805                 810                 815     


Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu Glu Arg Thr Gln 
            820                 825                 830         


Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu Leu Tyr Gln Ile 
        835                 840                 845             


Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly Glu Thr Val Gln 
    850                 855                 860                 


Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
865                 870                 875                 880 


Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln Val Val Thr Leu 
                885                 890                 895     


Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile Asp Asn Phe Asp 
            900                 905                 910         


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Val Ser Gly 
        915                 920                 925             


Leu Pro Val Arg Asn Gly Gln Leu His Ala Arg Glu Val Ala Arg Met 
    930                 935                 940                 


Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg Ile Arg His Arg 
945                 950                 955                 960 


Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His Thr Gly Pro Val 
                965                 970                 975     


Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr Cys Leu Phe Gly 
            980                 985                 990         


Asp Thr Val Asn Thr Ala Ser Arg  Met Glu Ser Asn Gly  Glu Ala Leu 
        995                 1000                 1005             


Arg Ile  His Leu Ser Ser Glu  Thr Lys Ala Val Leu  Glu Glu Phe 
    1010                 1015                 1020             


Asp Gly  Phe Glu Leu Glu Leu  Arg Gly Asp Val Glu  Met Lys Gly 
    1025                 1030                 1035             


Lys Gly  Lys Val Arg Thr Tyr  Trp Leu Leu Gly Glu  Arg Gly Cys 
    1040                 1045                 1050             


Ser Thr  Arg Gly 
    1055         


