                               SEQUENCE LISTING

<110> LEE, ALLEN J.
 
<120> RATIONALE-BASED DESIGN OF A TARGETED THERAPY FOR CANCER

<130> 45824-701.601

<140> PCT/US2014/068373
<141> 2014-12-03

<150> 61/911,423
<151> 2013-12-03

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Asp Ser Thr Thr 
1               


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Asp Val Ser Ser Thr 
1               5   


<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Glu Val Thr Ser Thr Thr 
1               5       


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Asp Ser Thr Ser Ser 
1               5   


<210> 5
<211> 5
<212> PRT
<213> Homo sapiens

<400> 5
Asp Ser Ser Thr Thr 
1               5   


<210> 6
<211> 5
<212> PRT
<213> Homo sapiens

<400> 6
Asp Glu Ser Ser Ser 
1               5   


<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Lys Ala Ala Ser Ala Asp Ser Thr Thr Glu Gly Thr Pro Ala Asp 
1               5                   10                  15  


<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Asn Thr Leu Phe Pro Asp Val Ser Ser Ser Thr His 
1               5                   10          


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Asp Glu Val Thr Ser Thr Thr Ser Ser Ser 
1               5                   10  


<210> 10
<211> 170
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Gln Glu Thr Asn His Ser Gln Val Pro Met Leu Cys Ser Thr 
1               5                   10                  15      


Gly Cys Gly Phe Tyr Gly Asn Pro Arg Thr Asn Gly Met Cys Ser Val 
            20                  25                  30          


Cys Tyr Lys Glu His Leu Gln Arg Gln Asn Ser Ser Asn Gly Arg Ile 
        35                  40                  45              


Ser Pro Pro Ala Thr Ser Val Ser Ser Leu Ser Glu Ser Leu Pro Val 
    50                  55                  60                  


Gln Cys Thr Asp Gly Ser Val Pro Glu Ala Gln Ser Ala Leu Asp Ser 
65                  70                  75                  80  


Thr Ser Ser Ser Met Gln Pro Ser Pro Val Ser Asn Gln Ser Leu Leu 
                85                  90                  95      


Ser Glu Ser Val Ala Ser Ser Gln Leu Asp Ser Thr Ser Val Asp Lys 
            100                 105                 110         


Ala Val Pro Glu Thr Glu Asp Val Gln Gly Phe Glu Cys Arg Cys Gly 
        115                 120                 125             


Asn Val Tyr Cys Gly Val His Arg Tyr Ser Asp Val His Asn Cys Ser 
    130                 135                 140                 


Tyr Asn Tyr Lys Ala Asp Ala Ala Glu Lys Ile Arg Lys Glu Asn Pro 
145                 150                 155                 160 


Val Val Val Gly Glu Lys Ile Gln Lys Ile 
                165                 170 


<210> 11
<211> 232
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
                85                  90                  95      


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
            100                 105                 110         


Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn 
        115                 120                 125             


Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr 
    130                 135                 140                 


Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser 
145                 150                 155                 160 


Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser 
                165                 170                 175     


Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn 
            180                 185                 190         


Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala 
        195                 200                 205             


Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp 
    210                 215                 220                 


Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230         


<210> 12
<211> 280
<212> PRT
<213> Homo sapiens

<400> 12
Met Met Ser Gln Ser Ser Gly Ser Gly Asp Gly Asn Asp Asp Glu Ala 
1               5                   10                  15      


Thr Thr Ser Lys Asp Gly Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala 
            20                  25                  30          


Ala Ala Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr 
        35                  40                  45              


Thr Pro Pro Thr Ser Ala Lys Lys Arg Lys Leu Asn Ser Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Asn Ser Ser Asn Glu Arg Glu Asp Phe Asp Ser Thr Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Thr Pro Pro Leu Gln Pro Arg Asp Ser Ala Ser Pro 
                85                  90                  95      


Ser Thr Ser Ser Phe Cys Leu Gly Val Ser Val Ala Ala Ser Ser His 
            100                 105                 110         


Val Pro Ile Gln Lys Lys Leu Arg Phe Glu Asp Thr Leu Glu Phe Val 
        115                 120                 125             


Gly Phe Asp Ala Lys Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Pro Thr Ala Ala Thr Ser Gln Gln Gln Gln Leu Lys Asn Lys 
145                 150                 155                 160 


Ser Ile Leu Ile Ser Ser Val Ala Ser Val His His Ala Asn Gly Leu 
                165                 170                 175     


Ala Lys Ser Ser Thr Thr Val Ser Ser Phe Ala Asn Ser Lys Pro Gly 
            180                 185                 190         


Ser Ala Lys Lys Leu Val Ile Lys Asn Phe Lys Asp Lys Pro Lys Leu 
        195                 200                 205             


Pro Glu Asn Tyr Thr Asp Glu Thr Trp Gln Lys Leu Lys Glu Ala Val 
    210                 215                 220                 


Glu Ala Ile Gln Asn Ser Thr Ser Ile Lys Tyr Asn Leu Glu Glu Leu 
225                 230                 235                 240 


Tyr Gln Ala Val Glu Asn Leu Cys Ser Tyr Lys Ile Ser Ala Asn Leu 
                245                 250                 255     


Tyr Lys Gln Leu Arg Gln Ile Cys Glu Asp His Ile Lys Ala Gln Ile 
            260                 265                 270         


His Gln Phe Arg Glu Asp Ser Leu 
        275                 280 


<210> 13
<211> 210
<212> PRT
<213> Homo sapiens

<400> 13
Trp Glu Lys Val Glu Val Ser Ser Asn Pro His Arg Ala Ser Lys Leu 
1               5                   10                  15      


Thr Asp His Asn Pro Lys Thr Tyr Trp Glu Ser Asn Gly Ser Ala Gly 
            20                  25                  30          


Ser His Tyr Ile Thr Leu His Met Arg Arg Gly Ile Leu Ile Arg Gln 
        35                  40                  45              


Leu Thr Leu Leu Val Ala Ser Glu Asp Ser Ser Tyr Met Pro Ala Arg 
    50                  55                  60                  


Val Val Val Cys Gly Gly Asp Ser Thr Ser Ser Leu His Thr Glu Leu 
65                  70                  75                  80  


Asn Ser Val Asn Val Met Pro Ser Ala Ser Arg Val Ile Leu Leu Glu 
                85                  90                  95      


Asn Leu Thr Arg Phe Trp Pro Ile Ile Gln Ile Arg Ile Lys Arg Cys 
            100                 105                 110         


Gln Gln Gly Gly Ile Asp Thr Arg Ile Arg Gly Leu Glu Ile Leu Gly 
        115                 120                 125             


Pro Lys Pro Thr Phe Trp Pro Val Phe Arg Glu Gln Leu Cys Arg His 
    130                 135                 140                 


Thr Arg Leu Phe Tyr Met Val Arg Ala Gln Ala Trp Ser Gln Asp Met 
145                 150                 155                 160 


Ala Glu Asp Arg Arg Ser Leu Leu His Leu Ser Ser Arg Leu Asn Gly 
                165                 170                 175     


Ala Leu Arg Gln Glu Gln Asn Phe Ala Asp Arg Phe Leu Pro Asp Asp 
            180                 185                 190         


Glu Ala Ala Gln Ala Leu Gly Lys Thr Cys Trp Glu Ala Leu Val Ser 
        195                 200                 205             


Pro Val 
    210 


<210> 14
<211> 375
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Ala Ser Ala Pro Ala Ala Glu Gly Glu Gly Thr Pro Thr Gln 
1               5                   10                  15      


Pro Ala Ser Glu Lys Glu Pro Glu Met Pro Gly Pro Arg Glu Glu Ser 
            20                  25                  30          


Glu Glu Glu Glu Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Lys 
        35                  40                  45              


Glu Lys Ser Leu Ile Val Glu Gly Lys Arg Glu Lys Lys Lys Val Glu 
    50                  55                  60                  


Arg Leu Thr Met Gln Val Ser Ser Leu Gln Arg Glu Pro Phe Thr Ile 
65                  70                  75                  80  


Ala Gln Gly Lys Gly Gln Lys Leu Cys Glu Ile Glu Arg Ile His Phe 
                85                  90                  95      


Phe Leu Ser Lys Lys Lys Thr Asp Glu Leu Arg Asn Leu His Lys Leu 
            100                 105                 110         


Leu Tyr Asn Arg Pro Gly Thr Val Ser Ser Leu Lys Lys Asn Val Gly 
        115                 120                 125             


Gln Phe Ser Gly Phe Pro Phe Glu Lys Gly Ser Val Gln Tyr Lys Lys 
    130                 135                 140                 


Lys Glu Glu Met Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile 
145                 150                 155                 160 


Cys Glu Val Leu Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val 
                165                 170                 175     


Lys Arg Ile Leu Asn Phe Leu Met His Pro Lys Pro Ser Gly Lys Pro 
            180                 185                 190         


Leu Pro Lys Ser Lys Lys Thr Cys Ser Lys Gly Ser Lys Lys Glu Arg 
        195                 200                 205             


Asn Ser Ser Gly Met Ala Arg Lys Ala Lys Arg Thr Lys Cys Pro Glu 
    210                 215                 220                 


Ile Leu Ser Asp Glu Ser Ser Ser Asp Glu Asp Glu Lys Lys Asn Lys 
225                 230                 235                 240 


Glu Glu Ser Ser Asp Asp Glu Asp Lys Glu Ser Glu Glu Glu Pro Pro 
                245                 250                 255     


Lys Lys Thr Ala Lys Arg Glu Lys Pro Lys Gln Lys Ala Thr Ser Lys 
            260                 265                 270         


Ser Lys Lys Ser Val Lys Ser Ala Asn Val Lys Lys Ala Asp Ser Ser 
        275                 280                 285             


Thr Thr Lys Lys Asn Gln Asn Ser Ser Lys Lys Glu Ser Glu Ser Glu 
    290                 295                 300                 


Asp Ser Ser Asp Asp Glu Pro Leu Ile Lys Lys Leu Lys Lys Pro Pro 
305                 310                 315                 320 


Thr Asp Glu Glu Leu Lys Glu Thr Ile Lys Lys Leu Leu Ala Ser Ala 
                325                 330                 335     


Asn Leu Glu Glu Val Thr Met Lys Gln Ile Cys Lys Lys Val Tyr Glu 
            340                 345                 350         


Asn Tyr Pro Thr Tyr Asp Leu Thr Glu Arg Lys Asp Phe Ile Lys Thr 
        355                 360                 365             


Thr Val Lys Glu Leu Ile Ser 
    370                 375 


<210> 15
<211> 374
<212> PRT
<213> Homo sapiens

<400> 15
Met Ser Arg Val Pro Ser Pro Pro Pro Pro Ala Glu Met Ser Ser Gly 
1               5                   10                  15      


Pro Val Ala Glu Ser Trp Cys Tyr Thr Gln Ile Lys Val Val Lys Phe 
            20                  25                  30          


Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met 
        35                  40                  45              


Gly Glu Val Ile Lys Ser Ser Thr Phe Ser Ser Gly Ala Asn Asp Lys 
    50                  55                  60                  


Leu Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Glu Glu Ser 
65                  70                  75                  80  


Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser 
                85                  90                  95      


Glu Val Arg Ala Lys Phe Lys Phe Ser Ile Leu Asn Ala Lys Gly Glu 
            100                 105                 110         


Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly 
        115                 120                 125             


Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp 
    130                 135                 140                 


Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu 
145                 150                 155                 160 


Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly Gln Asn Thr Met 
                165                 170                 175     


Asn Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly 
            180                 185                 190         


Leu Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly 
        195                 200                 205             


Gln Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val 
    210                 215                 220                 


Phe Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg 
225                 230                 235                 240 


Val Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys 
                245                 250                 255     


Phe Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp 
            260                 265                 270         


Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met 
        275                 280                 285             


Cys Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu 
    290                 295                 300                 


Ile Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln 
305                 310                 315                 320 


Ala Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser 
                325                 330                 335     


Gly Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala 
            340                 345                 350         


Tyr Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg 
        355                 360                 365             


Lys Arg Leu Lys Gln Ser 
    370                 


