                         SEQUENCE LISTING

<110>  Yu, Fu-Shin
 
<120>  COMPOSITIONS AND METHODS TO DIAGNOSE DIABETES AND/OR TO TREAT 
       NEGATIVE EFFECTS OF DIABETES

<130>  W063-0013PCT

<150>  61/910,831
<151>  2013-12-02

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  2
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Val Lys Pro Gln Gly Leu Val Val Thr Ser Ser Ala Val Cys 
1               5                   10                  15      


Ser Ser Pro Asp Tyr Leu Arg Glu Pro Lys Tyr Tyr Pro Gly Gly Pro 
            20                  25                  30          


Pro Thr Pro Arg Pro Leu Leu Pro Thr Arg Pro Pro Ala Ser Pro Pro 
        35                  40                  45              


Asp Lys Ala Phe Ser Thr His Ala Phe Ser Glu Asn Pro Arg Pro Pro 
    50                  55                  60                  


Pro Arg Arg Asp Pro Ser Thr Arg Arg Pro Pro Val Leu Ala Lys Gly 
65                  70                  75                  80  


Asp Asp Pro Leu Pro Pro Arg Ala Ala Arg Pro Val Ser Gln Ala Arg 
                85                  90                  95      


Cys Pro Thr Pro Val Gly Asp Gly Ser Ser Ser Arg Arg Cys Trp Asp 
            100                 105                 110         


Asn Gly Arg Val Asn Leu Arg Pro Val Val Gln Leu Ile Asp Ile Met 
        115                 120                 125             


Lys Asp Leu Thr Arg Leu Ser Gln Asp Leu Gln His Ser Gly Val His 
    130                 135                 140                 


Leu Asp Cys Gly Gly Leu Arg Leu Ser Arg Pro Pro Ala Pro Pro Pro 
145                 150                 155                 160 


Gly Asp Leu Gln Tyr Ser Phe Phe Ser Ser Pro Ser Leu Ala Asn Ser 
                165                 170                 175     


Ile Arg Ser Pro Glu Glu Arg Ala Thr Pro His Ala Lys Ser Glu Arg 
            180                 185                 190         


Pro Ser His Pro Leu Tyr Glu Pro Glu Pro Glu Pro Arg Asp Ser Pro 
        195                 200                 205             


Gln Pro Gly Gln Gly His Ser Pro Gly Ala Thr Ala Ala Ala Thr Gly 
    210                 215                 220                 


Leu Pro Pro Glu Pro Glu Pro Asp Ser Thr Asp Tyr Ser Glu Leu Ala 
225                 230                 235                 240 


Asp Ala Asp Ile Leu Ser Glu Leu Ala Ser Leu Thr Cys Pro Glu Ala 
                245                 250                 255     


Gln Leu Leu Glu Ala Gln Ala Leu Glu Pro Pro Ser Pro Glu Pro Glu 
            260                 265                 270         


Pro Gln Leu Leu Asp Pro Gln Pro Arg Phe Leu Asp Pro Gln Ala Leu 
        275                 280                 285             


Glu Pro Leu Gly Glu Ala Leu Glu Leu Pro Pro Leu Gln Pro Leu Ala 
    290                 295                 300                 


Asp Pro Leu Gly Leu Pro Gly Leu Ala Leu Gln Ala Leu Asp Thr Leu 
305                 310                 315                 320 


Pro Asp Ser Leu Glu Ser Gln Leu Leu Asp Pro Gln Ala Leu Asp Pro 
                325                 330                 335     


Leu Pro Lys Leu Leu Asp Val Pro Gly Arg Arg Leu Glu Pro Gln Gln 
            340                 345                 350         


Pro Leu Gly His Cys Pro Leu Ala Glu Pro Leu Arg Leu Asp Leu Cys 
        355                 360                 365             


Ser Pro His Gly Pro Pro Gly Pro Glu Gly His Pro Lys Tyr Ala Leu 
    370                 375                 380                 


Arg Arg Thr Asp Arg Pro Lys Ile Leu Cys Arg Arg Arg Lys Ala Gly 
385                 390                 395                 400 


Arg Gly Arg Lys Ala Asp Ala Gly Pro Glu Gly Arg Leu Leu Pro Leu 
                405                 410                 415     


Pro Met Pro Thr Gly Leu Val Ala Ala Leu Ala Glu Pro Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Pro Pro Pro Ala Leu Pro Gly Pro Gly Pro Val Ser Val 
        435                 440                 445             


Pro Glu Leu Lys Pro Glu Ser Ser Gln Thr Pro Val Val Ser Thr Arg 
    450                 455                 460                 


Lys Gly Lys Cys Arg Gly Val Arg Arg Met Val Val Lys Met Ala Lys 
465                 470                 475                 480 


Ile Pro Val Ser Leu Gly Arg Arg Asn Lys Thr Thr Tyr Lys Val Ser 
                485                 490                 495     


Ser Leu Ser Ser Ser Leu Ser Val Glu Gly Lys Glu Leu Gly Leu Arg 
            500                 505                 510         


Val Ser Ala Glu Pro Thr Pro Leu Leu Lys Met Lys Asn Asn Gly Arg 
        515                 520                 525             


Asn Val Val Val Val Phe Pro Pro Gly Glu Met Pro Ile Ile Leu Lys 
    530                 535                 540                 


Arg Lys Arg Gly Arg Pro Pro Lys Asn Leu Leu Leu Gly Pro Gly Lys 
545                 550                 555                 560 


Pro Lys Glu Pro Ala Val Val Ala Ala Glu Ala Ala Thr Val Ala Ala 
                565                 570                 575     


Ala Thr Met Ala Met Pro Glu Val Lys Lys Arg Arg Arg Arg Lys Gln 
            580                 585                 590         


Lys Leu Ala Ser Pro Gln Pro Ser Tyr Ala Ala Asp Ala Asn Asp Ser 
        595                 600                 605             


Lys Ala Glu Tyr Ser Asp Val Leu Ala Lys Leu Ala Phe Leu Asn Arg 
    610                 615                 620                 


Gln Ser Gln Cys Ala Gly Arg Cys Ser Pro Pro Arg Cys Trp Thr Pro 
625                 630                 635                 640 


Ser Glu Pro Glu Ser Val His Gln Ala Pro Asp Thr Gln Ser Ile Ser 
                645                 650                 655     


His Phe Leu His Arg Val Gln Gly Phe Arg Arg Arg Gly Gly Lys Ala 
            660                 665                 670         


Gly Gly Phe Gly Gly Arg Gly Gly Gly His Ala Ala Lys Ser Ala Arg 
        675                 680                 685             


Cys Ser Phe Ser Asp Phe Phe Glu Gly Ile Gly Lys Lys Lys Lys Val 
    690                 695                 700                 


Val Ala Val Ala Ala Ala Gly Val Gly Gly Pro Gly Leu Thr Glu Leu 
705                 710                 715                 720 


Gly His Pro Arg Lys Arg Gly Arg Gly Glu Val Asp Ala Val Thr Gly 
                725                 730                 735     


Lys Pro Lys Arg Lys Arg Arg Ser Arg Lys Asn Gly Thr Leu Phe Pro 
            740                 745                 750         


Glu Gln Val Pro Ser Gly Pro Gly Phe Gly Glu Ala Gly Ala Glu Trp 
        755                 760                 765             


Ala Gly Asp Lys Gly Gly Gly Trp Ala Pro His His Gly His Pro Gly 
    770                 775                 780                 


Gly Gln Ala Gly Arg Asn Cys Gly Phe Gln Gly Thr Glu Ala Arg Ala 
785                 790                 795                 800 


Phe Ala Ser Thr Gly Leu Glu Ser Gly Ala Ser Gly Arg Gly Ser Tyr 
                805                 810                 815     


Tyr Ser Thr Gly Ala Pro Ser Gly Gln Thr Glu Leu Ser Gln Glu Arg 
            820                 825                 830         


Gln Asn Leu Phe Thr Gly Tyr Phe Arg Ser Leu Leu Asp Ser Asp Asp 
        835                 840                 845             


Ser Ser Asp Leu Leu Asp Phe Ala Leu Ser Ala Ser Arg Pro Glu Ser 
    850                 855                 860                 


Arg Lys Ala Ser Gly Thr Tyr Ala Gly Pro Pro Thr Ser Ala Leu Pro 
865                 870                 875                 880 


Ala Gln Arg Gly Leu Ala Thr Phe Pro Ser Arg Gly Ala Lys Ala Ser 
                885                 890                 895     


Pro Val Ala Val Gly Ser Ser Gly Ala Gly Ala Asp Pro Ser Phe Gln 
            900                 905                 910         


Pro Val Leu Ser Ala Arg Gln Thr Phe Pro Pro Gly Arg Ala Ala Ser 
        915                 920                 925             


Tyr Gly Leu Thr Pro Ala Ala Ser Asp Cys Arg Ala Ala Glu Thr Phe 
    930                 935                 940                 


Pro Lys Leu Val Pro Pro Pro Ser Ala Met Ala Arg Ser Pro Thr Thr 
945                 950                 955                 960 


His Pro Pro Ala Asn Thr Tyr Leu Pro Gln Tyr Gly Gly Tyr Gly Ala 
                965                 970                 975     


Gly Gln Ser Val Phe Ala Pro Thr Lys Pro Phe Thr Gly Gln Asp Cys 
            980                 985                 990         


Ala Asn Ser Lys Asp Cys Ser Phe  Ala Tyr Gly Ser Gly  Asn Ser Leu 
        995                 1000                 1005             


Pro Ala  Ser Pro Ser Ser Ala  His Ser Ala Gly Tyr  Ala Pro Pro 
    1010                 1015                 1020             


Pro Thr  Gly Gly Pro Cys Leu  Pro Pro Ser Lys Ala  Ser Phe Phe 
    1025                 1030                 1035             


Ser Ser  Ser Glu Gly Ala Pro  Phe Ser Gly Ser Ala  Pro Thr Pro 
    1040                 1045                 1050             


Leu Arg  Cys Asp Ser Arg Ala  Ser Thr Val Ser Pro  Gly Gly Tyr 
    1055                 1060                 1065             


Met Val  Pro Lys Gly Thr Thr  Ala Ser Ala Thr Ser  Ala Ala Ser 
    1070                 1075                 1080             


Ala Ala  Ser Ser Ser Ser Ser  Ser Phe Gln Pro Ser  Pro Glu Asn 
    1085                 1090                 1095             


Cys Arg  Gln Phe Ala Gly Ala  Ser Gln Trp Pro Phe  Arg Gln Gly 
    1100                 1105                 1110             


Tyr Gly  Gly Leu Asp Trp Ala  Ser Glu Ala Phe Ser  Gln Leu Tyr 
    1115                 1120                 1125             


Asn Pro  Ser Phe Asp Cys His  Val Ser Glu Pro Asn  Val Ile Leu 
    1130                 1135                 1140             


Asp Ile  Ser Asn Tyr Thr Pro  Gln Lys Val Lys Gln  Gln Thr Ala 
    1145                 1150                 1155             


Val Ser  Glu Thr Phe Ser Glu  Ser Ser Ser Asp Ser  Thr Gln Phe 
    1160                 1165                 1170             


Asn Gln  Pro Val Gly Gly Gly  Gly Phe Arg Arg Ala  Asn Ser Glu 
    1175                 1180                 1185             


Ala Ser  Ser Ser Glu Gly Gln  Ser Ser Leu Ser Ser  Leu Glu Lys 
    1190                 1195                 1200             


Leu Met  Met Asp Trp Asn Glu  Ala Ser Ser Ala Pro  Gly Tyr Asn 
    1205                 1210                 1215             


Trp Asn  Gln Ser Val Leu Phe  Gln Ser Ser Ser Lys  Pro Gly Arg 
    1220                 1225                 1230             


Gly Arg  Arg Lys Lys Val Asp  Leu Phe Glu Ala Ser  His Leu Gly 
    1235                 1240                 1245             


Phe Pro  Thr Ser Ala Ser Ala  Ala Ala Ser Gly Tyr  Pro Ser Lys 
    1250                 1255                 1260             


Arg Ser  Thr Gly Pro Arg Gln  Pro Arg Gly Gly Arg  Gly Gly Gly 
    1265                 1270                 1275             


Ala Cys  Ser Ala Lys Lys Glu  Arg Gly Gly Ala Ala  Ala Lys Ala 
    1280                 1285                 1290             


Lys Phe  Ile Pro Lys Pro Gln  Pro Val Asn Pro Leu  Phe Gln Asp 
    1295                 1300                 1305             


Ser Pro  Asp Leu Gly Leu Asp  Tyr Tyr Ser Gly Asp  Ser Ser Met 
    1310                 1315                 1320             


Ser Pro  Leu Pro Ser Gln Ser  Arg Ala Phe Gly Val  Gly Glu Arg 
    1325                 1330                 1335             


Asp Pro  Cys Asp Phe Ile Gly  Pro Tyr Ser Met Asn  Pro Ser Thr 
    1340                 1345                 1350             


Pro Ser  Asp Gly Thr Phe Gly  Gln Gly Phe His Cys  Asp Ser Pro 
    1355                 1360                 1365             


Ser Leu  Gly Ala Pro Glu Leu  Asp Gly Lys His Phe  Pro Pro Leu 
    1370                 1375                 1380             


Ala His  Pro Pro Thr Val Phe  Asp Ala Gly Leu Gln  Lys Ala Tyr 
    1385                 1390                 1395             


Ser Pro  Thr Cys Ser Pro Thr  Leu Gly Phe Lys Glu  Glu Leu Arg 
    1400                 1405                 1410             


Pro Pro  Pro Thr Lys Leu Ala  Ala Cys Glu Pro Leu  Lys His Gly 
    1415                 1420                 1425             


Leu Gln  Gly Ala Ser Leu Gly  His Ala Ala Ala Ala  Gln Ala His 
    1430                 1435                 1440             


Leu Ser  Cys Arg Asp Leu Pro  Leu Gly Gln Pro His  Tyr Asp Ser 
    1445                 1450                 1455             


Pro Ser  Cys Lys Gly Thr Ala  Tyr Trp Tyr Pro Pro  Gly Ser Ala 
    1460                 1465                 1470             


Ala Arg  Ser Pro Pro Tyr Glu  Gly Lys Val Gly Thr  Gly Leu Leu 
    1475                 1480                 1485             


Ala Asp  Phe Leu Gly Arg Thr  Glu Ala Ala Cys Leu  Ser Ala Pro 
    1490                 1495                 1500             


His Leu  Ala Ser Pro Pro Ala  Thr Pro Lys Ala Asp  Lys Glu Pro 
    1505                 1510                 1515             


Leu Glu  Met Ala Arg Pro Pro  Gly Pro Pro Arg Gly  Pro Ala Ala 
    1520                 1525                 1530             


Ala Ala  Ala Gly Tyr Gly Cys  Pro Leu Leu Ser Asp  Leu Thr Leu 
    1535                 1540                 1545             


Ser Pro  Val Pro Arg Asp Ser  Leu Leu Pro Leu Gln  Asp Thr Ala 
    1550                 1555                 1560             


Tyr Arg  Tyr Pro Gly Phe Met  Pro Gln Ala His Pro  Gly Leu Gly 
    1565                 1570                 1575             


Gly Gly  Pro Lys Ser Gly Phe  Leu Gly Pro Met Ala  Glu Pro His 
    1580                 1585                 1590             


Pro Glu  Asp Thr Phe Thr Val  Thr Ser Leu 
    1595                 1600             


<210>  3
<211>  316
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Pro Asn Gln Val Lys Glu Ala Val 
            20                  25                  30          


Lys Ala Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Ala 
        35                  40                  45              


Tyr Cys Asn Glu Asn Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Lys 
    50                  55                  60                  


Glu Lys Ala Val Gln Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Cys Phe Glu Lys Lys Leu Leu Lys Glu Ala Phe Gln Lys Thr 
                85                  90                  95      


Leu Thr Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Leu Gln Pro Gly Lys Glu Leu Phe Pro Lys Asp Asp Gln 
        115                 120                 125             


Gly Arg Ile Leu Thr Ser Lys Thr Thr Phe Leu Glu Ala Trp Glu Gly 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Gln Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Asn His Phe Gln Ile Glu Arg Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys His Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Ser Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Ser Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ser Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Val Val Ile Pro Lys Ser Val Thr Pro Ser Arg Ile Gln Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Gln Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Leu Leu Pro Glu Thr 
    290                 295                 300                 


Val Asn Met Glu Glu Tyr Pro Tyr Asp Ala Glu Tyr 
305                 310                 315     


<210>  4
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Glu Leu Arg Ser Ile Ala Phe Ser Arg Ala Val Phe Ala Glu 
1               5                   10                  15      


Phe Leu Ala Thr Leu Leu Phe Val Phe Phe Gly Leu Gly Ser Ala Leu 
            20                  25                  30          


Asn Trp Pro Gln Ala Leu Pro Ser Val Leu Gln Ile Ala Met Ala Phe 
        35                  40                  45              


Gly Leu Gly Ile Gly Thr Arg Val Gln Ala Leu Gly His Ile Ser Gly 
    50                  55                  60                  


Ala His Ile Asn Pro Ala Val Thr Val Ala Cys Leu Val Gly Cys His 
65                  70                  75                  80  


Val Ser Val Leu Arg Ala Ala Phe Tyr Val Ala Ala Gln Leu Leu Gly 
                85                  90                  95      


Ala Val Ala Gly Ala Ala Leu Leu His Glu Ile Thr Pro Ala Asp Ile 
            100                 105                 110         


Arg Gly Asp Leu Ala Val Asn Ala Leu Ser Asn Ser Thr Thr Ala Gly 
        115                 120                 125             


Gln Ala Val Thr Val Glu Leu Phe Leu Thr Leu Gln Leu Val Leu Cys 
    130                 135                 140                 


Ile Phe Ala Ser Thr Asp Glu Arg Arg Gly Glu Asn Pro Gly Thr Pro 
145                 150                 155                 160 


Ala Leu Ser Ile Gly Phe Ser Val Ala Leu Gly His Leu Leu Gly Ile 
                165                 170                 175     


His Tyr Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Leu Ala Pro Ala 
            180                 185                 190         


Val Val Thr Gly Lys Phe Asp Asp His Trp Val Phe Trp Ile Gly Pro 
        195                 200                 205             


Leu Val Gly Ala Ile Leu Gly Ser Leu Leu Tyr Asn Tyr Val Leu Phe 
    210                 215                 220                 


Pro Pro Ala Lys Ser Leu Ser Glu Arg Leu Ala Val Leu Lys Gly Leu 
225                 230                 235                 240 


Glu Pro Asp Thr Asp Trp Glu Glu Arg Glu Val Arg Arg Arg Gln Ser 
                245                 250                 255     


Val Glu Leu His Ser Pro Gln Ser Leu Pro Arg Gly Thr Lys Ala 
            260                 265                 270     


<210>  5
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Asn Ser Thr Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Thr Arg Val Thr Thr Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Thr Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Thr Leu Gly Ser Phe Ser Thr Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Thr Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Thr Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Thr Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Thr Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Thr Thr 
            340                 345                 350         


His Leu Met Phe His Thr Val Thr Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Thr Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Thr Leu Glu Val Leu Tyr Met Leu Thr Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Thr Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Thr Gln Thr His Val Ala 
                485                 490                 495     


Ser Ala Pro Gly 
            500 


<210>  6
<211>  1793
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asn Ser Thr Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Thr Arg Val Thr Thr Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Thr Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Thr Leu Gly Ser Phe Ser Thr Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Thr Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Thr Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Thr Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Thr Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Thr Thr 
            340                 345                 350         


His Leu Met Phe His Thr Val Thr Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Thr Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Thr Leu Glu Val Leu Tyr Met Leu Thr Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Thr Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Thr Gln Thr His Val Ala 
                485                 490                 495     


Ser Ala Pro Ala Ser Arg Ala Val Val Ala Gln His Val Ala Pro Pro 
            500                 505                 510         


Pro Gly Ile Val Glu Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu 
        515                 520                 525             


Asn Ala His Phe Glu Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu 
    530                 535                 540                 


Met Tyr Ser Glu Tyr Leu Ser Thr Cys Ser Lys Leu Ala Arg Gly Gly 
545                 550                 555                 560 


Ile Leu Thr Ser Thr Gly Phe Tyr Lys Cys Leu Arg Thr Val Phe Pro 
                565                 570                 575     


Asn His Thr Val Lys Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala 
            580                 585                 590         


His Ile His Val Val Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile 
        595                 600                 605             


Gln Met Tyr Tyr Gln Gln Gln Pro Val Ser Thr Ser Val Val Arg Val 
    610                 615                 620                 


Asp Ser Val Pro Asp Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro 
625                 630                 635                 640 


His Gly Ser Gln Thr Ile Gly Asn His Phe Gln Arg Thr Pro Val Ala 
                645                 650                 655     


Asn Gln Ser Ser Asn Leu Thr Ala Thr Gln Met Ser Phe Pro Val Gln 
            660                 665                 670         


Gly Val His Thr Val Ala Gln Thr Val Ser Arg Ile Pro Gln Asn Pro 
        675                 680                 685             


Ser Pro His Thr His Gln Gln Gln Asn Ala Pro Val Thr Val Ile Gln 
    690                 695                 700                 


Ser Lys Ala Pro Ile Pro Cys Glu Val Val Lys Ala Thr Val Ile Gln 
705                 710                 715                 720 


Asn Ser Ile Pro Gln Thr Gly Val Pro Val Ser Ile Ala Val Gly Gly 
                725                 730                 735     


Gly Pro Pro Gln Ser Ser Val Val Gln Asn His Ser Thr Gly Pro Gln 
            740                 745                 750         


Pro Val Thr Val Val Asn Ser Gln Thr Leu Leu His His Pro Ser Val 
        755                 760                 765             


Ile Pro Gln Gln Ser Pro Leu His Thr Val Val Pro Gly Gln Ile Pro 
    770                 775                 780                 


Ser Gly Thr Pro Val Thr Val Ile Gln Gln Ala Val Pro Gln Ser His 
785                 790                 795                 800 


Met Phe Gly Arg Val Gln Asn Ile Pro Ala Cys Thr Ser Thr Val Ser 
                805                 810                 815     


Gln Gly Gln Gln Leu Ile Thr Thr Ser Pro Gln Pro Val Gln Thr Ser 
            820                 825                 830         


Ser Gln Gln Thr Ser Ala Gly Ser Gln Ser Gln Asp Thr Val Ile Ile 
        835                 840                 845             


Ala Pro Pro Gln Tyr Val Thr Thr Ser Ala Ser Asn Ile Val Ser Ala 
    850                 855                 860                 


Thr Ser Val Gln Asn Phe Gln Val Ala Thr Gly Gln Met Val Thr Ile 
865                 870                 875                 880 


Ala Gly Val Pro Ser Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile 
                885                 890                 895     


Ala Pro Lys Pro Leu Pro Ser Gln Gln Val Ser Ser Thr Val Val Gln 
            900                 905                 910         


Gln Pro Ile Gln Gln Pro Gln Gln Pro Thr Gln Gln Ser Val Val Ile 
        915                 920                 925             


Val Ser Gln Pro Ala Gln Gln Gly Gln Thr Tyr Ala Pro Ala Ile His 
    930                 935                 940                 


Gln Ile Val Leu Ala Asn Pro Ala Ala Leu Pro Ala Gly Gln Thr Val 
945                 950                 955                 960 


Gln Leu Thr Gly Gln Pro Asn Ile Thr Pro Ser Ser Ser Pro Ser Pro 
                965                 970                 975     


Val Pro Ala Thr Asn Asn Gln Val Pro Thr Ala Met Ser Ser Ser Ser 
            980                 985                 990         


Thr Pro Gln Ser Gln Gly Pro Pro  Pro Thr Val Ser Gln  Met Leu Ser 
        995                 1000                 1005             


Val Lys  Arg Gln Gln Gln Gln  Gln His Ser Pro Ala  Pro Pro Pro 
    1010                 1015                 1020             


Gln Gln  Val Gln Val Gln Val  Gln Gln Pro Gln Gln  Val Gln Met 
    1025                 1030                 1035             


Gln Val  Gln Pro Gln Gln Ser  Asn Ala Gly Val Gly  Gln Pro Ala 
    1040                 1045                 1050             


Ser Gly  Glu Ser Ser Leu Ile  Lys Gln Leu Leu Leu  Pro Lys Arg 
    1055                 1060                 1065             


Gly Pro  Ser Thr Pro Gly Gly  Lys Leu Ile Leu Pro  Ala Pro Gln 
    1070                 1075                 1080             


Ile Pro  Pro Pro Asn Asn Ala  Arg Ala Pro Ser Pro  Gln Val Val 
    1085                 1090                 1095             


Tyr Gln  Val Ala Ser Asn Gln  Ala Ala Gly Phe Gly  Val Gln Gly 
    1100                 1105                 1110             


Gln Thr  Pro Ala Gln Gln Leu  Leu Val Gly Gln Gln  Asn Val Gln 
    1115                 1120                 1125             


Leu Val  Pro Ser Ala Met Pro  Pro Ser Gly Gly Val  Gln Thr Val 
    1130                 1135                 1140             


Pro Ile  Ser Asn Leu Gln Ile  Leu Pro Gly Pro Leu  Ile Ser Asn 
    1145                 1150                 1155             


Ser Pro  Ala Thr Ile Phe Gln  Gly Thr Ser Gly Asn  Gln Val Thr 
    1160                 1165                 1170             


Ile Thr  Val Val Pro Asn Thr  Ser Phe Ala Pro Ala  Thr Val Ser 
    1175                 1180                 1185             


Gln Gly  Asn Ala Thr Gln Leu  Ile Ala Pro Ala Gly  Ile Thr Met 
    1190                 1195                 1200             


Ser Gly  Thr Gln Thr Gly Val  Gly Leu Pro Val Gln  Thr Leu Pro 
    1205                 1210                 1215             


Ala Thr  Gln Ala Ser Pro Ala  Gly Gln Ser Ser Cys  Thr Thr Ala 
    1220                 1225                 1230             


Thr Pro  Pro Phe Lys Gly Asp  Lys Ile Ile Cys Gln  Lys Glu Glu 
    1235                 1240                 1245             


Glu Ala  Lys Glu Ala Thr Gly  Leu His Val His Glu  Arg Lys Ile 
    1250                 1255                 1260             


Glu Val  Met Glu Asn Pro Ser  Cys Arg Arg Gly Ala  Thr Asn Thr 
    1265                 1270                 1275             


Ser Asn  Gly Asp Thr Lys Glu  Asn Glu Met His Val  Gly Ser Leu 
    1280                 1285                 1290             


Leu Asn  Gly Arg Lys Tyr Ser  Asp Ser Ser Leu Pro  Pro Ser Asn 
    1295                 1300                 1305             


Ser Gly  Lys Ile Gln Ser Glu  Thr Asn Gln Cys Ser  Leu Ile Ser 
    1310                 1315                 1320             


Asn Gly  Pro Ser Leu Glu Leu  Gly Glu Asn Gly Ala  Ser Gly Lys 
    1325                 1330                 1335             


Gln Asn  Ser Glu Gln Ile Asp  Met Gln Asp Ile Lys  Ser Asp Leu 
    1340                 1345                 1350             


Arg Lys  Pro Leu Val Asn Gly  Ile Cys Asp Phe Asp  Lys Gly Asp 
    1355                 1360                 1365             


Gly Ser  His Leu Ser Lys Asn  Ile Pro Asn His Lys  Thr Ser Asn 
    1370                 1375                 1380             


His Val  Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Thr 
    1385                 1390                 1395             


Leu Asp  Ile Thr Gln Gln Asp  Thr Ala Lys Gly Asp  Gln Leu Glu 
    1400                 1405                 1410             


Arg Ile  Ser Asn Gly Pro Val  Leu Thr Leu Gly Gly  Ser Ser Val 
    1415                 1420                 1425             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Thr Gln  Gln Phe Ser 
    1430                 1435                 1440             


Gly Thr  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1445                 1450                 1455             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1460                 1465                 1470             


Thr Thr  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1475                 1480                 1485             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1490                 1495                 1500             


Arg Ser  Thr Asn Gly Thr Ala  Glu Cys Lys Thr Val  Lys Arg Pro 
    1505                 1510                 1515             


Ala Glu  Asp Thr Asp Arg Glu  Thr Val Ala Gly Ile  Pro Asn Lys 
    1520                 1525                 1530             


Val Gly  Val Arg Ile Val Thr  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1535                 1540                 1545             


Cys Ser  Ala Thr Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1550                 1555                 1560             


Thr Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1565                 1570                 1575             


Gln His  Pro Pro Thr Tyr Val  Gln Asn Val Val Pro  Gln Asn Thr 
    1580                 1585                 1590             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1595                 1600                 1605             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1610                 1615                 1620             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1625                 1630                 1635             


Cys Lys  Lys Trp Phe Gln Thr  Pro Ser Gln Val Phe  Tyr His Ala 
    1640                 1645                 1650             


Ala Thr  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1655                 1660                 1665             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1670                 1675                 1680             


Thr His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1685                 1690                 1695             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1700                 1705                 1710             


Ser Thr  Lys Gln Pro Thr Val  Gly Gly Thr Ser Ser  Thr Pro Arg 
    1715                 1720                 1725             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1730                 1735                 1740             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Thr Asp 
    1745                 1750                 1755             


Glu Lys  Glu Gly Pro Ile Thr  Lys His Ile Arg Leu  Thr Ala Ala 
    1760                 1765                 1770             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1775                 1780                 1785             


Asn Met  Asn Glu Asp 
    1790             


<210>  7
<211>  1835
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Asn Ser Thr Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Thr Arg Val Thr Thr Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Thr Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Thr Leu Gly Ser Phe Ser Thr Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Thr Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Thr Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Thr Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Thr Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Thr Thr 
            340                 345                 350         


His Leu Met Phe His Thr Val Thr Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Thr Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Thr Leu Glu Val Leu Tyr Met Leu Thr Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Thr Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Thr Gln Thr His Val Ala 
                485                 490                 495     


Ser Ala Pro Ala Ser Arg Ala Val Val Ala Gln His Val Ala Pro Pro 
            500                 505                 510         


Pro Gly Ile Val Glu Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu 
        515                 520                 525             


Asn Ala His Phe Glu Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu 
    530                 535                 540                 


Met Tyr Ser Glu Tyr Leu Ser Thr Cys Ser Lys Leu Ala Arg Gly Gly 
545                 550                 555                 560 


Ile Leu Thr Ser Thr Gly Phe Tyr Lys Cys Leu Arg Thr Val Phe Pro 
                565                 570                 575     


Asn His Thr Val Lys Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala 
            580                 585                 590         


His Ile His Val Val Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile 
        595                 600                 605             


Gln Met Tyr Tyr Gln Gln Gln Pro Val Ser Thr Ser Val Val Arg Val 
    610                 615                 620                 


Asp Ser Val Pro Asp Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro 
625                 630                 635                 640 


His Gly Ser Gln Thr Ile Gly Asn His Phe Gln Arg Thr Pro Val Ala 
                645                 650                 655     


Asn Gln Ser Ser Asn Leu Thr Ala Thr Gln Met Ser Phe Pro Val Gln 
            660                 665                 670         


Gly Val His Thr Val Ala Gln Thr Val Ser Arg Ile Pro Gln Asn Pro 
        675                 680                 685             


Ser Pro His Thr His Gln Gln Gln Asn Ala Pro Val Thr Val Ile Gln 
    690                 695                 700                 


Ser Lys Ala Pro Ile Pro Cys Glu Val Val Lys Ala Thr Val Ile Gln 
705                 710                 715                 720 


Asn Ser Ile Pro Gln Thr Gly Val Pro Val Ser Ile Ala Val Gly Gly 
                725                 730                 735     


Gly Pro Pro Gln Ser Ser Val Val Gln Asn His Ser Thr Gly Pro Gln 
            740                 745                 750         


Pro Val Thr Val Val Asn Ser Gln Thr Leu Leu His His Pro Ser Val 
        755                 760                 765             


Ile Pro Gln Gln Ser Pro Leu His Thr Val Val Pro Gly Gln Ile Pro 
    770                 775                 780                 


Ser Gly Thr Pro Val Thr Val Ile Gln Gln Ala Val Pro Gln Ser His 
785                 790                 795                 800 


Met Phe Gly Arg Val Gln Asn Ile Pro Ala Cys Thr Ser Thr Val Ser 
                805                 810                 815     


Gln Gly Gln Gln Leu Ile Thr Thr Ser Pro Gln Pro Val Gln Thr Ser 
            820                 825                 830         


Ser Gln Gln Thr Ser Ala Gly Ser Gln Ser Gln Asp Thr Val Ile Ile 
        835                 840                 845             


Ala Pro Pro Gln Tyr Val Thr Thr Ser Ala Ser Asn Ile Val Ser Ala 
    850                 855                 860                 


Thr Ser Val Gln Asn Phe Gln Val Ala Thr Gly Gln Met Val Thr Ile 
865                 870                 875                 880 


Ala Gly Val Pro Ser Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile 
                885                 890                 895     


Ala Pro Lys Pro Leu Pro Ser Gln Gln Val Ser Ser Thr Val Val Gln 
            900                 905                 910         


Gln Pro Ile Gln Gln Pro Gln Gln Pro Thr Gln Gln Ser Val Val Ile 
        915                 920                 925             


Val Ser Gln Pro Ala Gln Gln Gly Gln Thr Tyr Ala Pro Ala Ile His 
    930                 935                 940                 


Gln Ile Val Leu Ala Asn Pro Ala Ala Leu Pro Ala Gly Gln Thr Val 
945                 950                 955                 960 


Gln Leu Thr Gly Gln Pro Asn Ile Thr Pro Ser Ser Ser Pro Ser Pro 
                965                 970                 975     


Val Pro Ala Thr Asn Asn Gln Val Pro Thr Ala Met Ser Ser Ser Ser 
            980                 985                 990         


Thr Pro Gln Ser Gln Gly Pro Pro  Pro Thr Val Ser Gln  Met Leu Ser 
        995                 1000                 1005             


Val Lys  Arg Gln Gln Gln Gln  Gln His Ser Pro Ala  Pro Pro Pro 
    1010                 1015                 1020             


Gln Gln  Val Gln Val Gln Val  Gln Gln Pro Gln Gln  Val Gln Met 
    1025                 1030                 1035             


Gln Val  Gln Pro Gln Gln Ser  Asn Ala Gly Val Gly  Gln Pro Ala 
    1040                 1045                 1050             


Ser Gly  Glu Ser Ser Leu Ile  Lys Gln Leu Leu Leu  Pro Lys Arg 
    1055                 1060                 1065             


Gly Pro  Ser Thr Pro Gly Gly  Lys Leu Ile Leu Pro  Ala Pro Gln 
    1070                 1075                 1080             


Ile Pro  Pro Pro Asn Asn Ala  Arg Ala Pro Ser Pro  Gln Val Val 
    1085                 1090                 1095             


Tyr Gln  Val Ala Ser Asn Gln  Ala Ala Gly Phe Gly  Val Gln Gly 
    1100                 1105                 1110             


Gln Thr  Pro Ala Gln Gln Leu  Leu Val Gly Gln Gln  Asn Val Gln 
    1115                 1120                 1125             


Leu Val  Pro Ser Ala Met Pro  Pro Ser Gly Gly Val  Gln Thr Val 
    1130                 1135                 1140             


Pro Ile  Ser Asn Leu Gln Ile  Leu Pro Gly Pro Leu  Ile Ser Asn 
    1145                 1150                 1155             


Ser Pro  Ala Thr Ile Phe Gln  Gly Thr Ser Gly Asn  Gln Val Thr 
    1160                 1165                 1170             


Ile Thr  Val Val Pro Asn Thr  Ser Phe Ala Pro Ala  Thr Val Ser 
    1175                 1180                 1185             


Gln Gly  Asn Ala Thr Gln Leu  Ile Ala Pro Ala Gly  Ile Thr Met 
    1190                 1195                 1200             


Ser Gly  Thr Gln Thr Gly Val  Gly Leu Pro Val Gln  Thr Leu Pro 
    1205                 1210                 1215             


Ala Thr  Gln Ala Ser Pro Ala  Gly Gln Ser Ser Cys  Thr Thr Ala 
    1220                 1225                 1230             


Thr Pro  Pro Phe Lys Gly Asp  Lys Ile Ile Cys Gln  Lys Glu Glu 
    1235                 1240                 1245             


Glu Ala  Lys Glu Ala Thr Gly  Leu His Val His Glu  Arg Lys Ile 
    1250                 1255                 1260             


Glu Val  Met Glu Asn Pro Ser  Cys Arg Arg Gly Ala  Thr Asn Thr 
    1265                 1270                 1275             


Ser Asn  Gly Asp Thr Lys Glu  Asn Glu Met His Val  Gly Ser Leu 
    1280                 1285                 1290             


Leu Asn  Gly Arg Lys Tyr Ser  Asp Ser Ser Leu Pro  Pro Ser Asn 
    1295                 1300                 1305             


Ser Gly  Lys Ile Gln Ser Glu  Thr Asn Gln Cys Ser  Leu Ile Ser 
    1310                 1315                 1320             


Asn Gly  Pro Ser Leu Glu Leu  Gly Glu Asn Gly Ala  Ser Gly Lys 
    1325                 1330                 1335             


Gln Asn  Ser Glu Gln Ile Asp  Met Gln Asp Ile Lys  Ser Asp Leu 
    1340                 1345                 1350             


Arg Lys  Pro Leu Val Asn Gly  Ile Cys Asp Phe Asp  Lys Gly Asp 
    1355                 1360                 1365             


Gly Ser  His Leu Ser Lys Asn  Ile Pro Asn His Lys  Thr Ser Asn 
    1370                 1375                 1380             


His Val  Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Thr 
    1385                 1390                 1395             


Leu Asp  Ile Thr Gln Gln Asp  Thr Ala Lys Gly Asp  Gln Leu Glu 
    1400                 1405                 1410             


Arg Ile  Ser Asn Gly Pro Val  Leu Thr Leu Gly Gly  Ser Ser Val 
    1415                 1420                 1425             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Thr Gln  Gln Phe Ser 
    1430                 1435                 1440             


Gly Thr  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1445                 1450                 1455             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1460                 1465                 1470             


Thr Thr  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1475                 1480                 1485             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1490                 1495                 1500             


Arg Ser  Thr Asn Gly Thr Ala  Glu Cys Lys Thr Val  Lys Arg Pro 
    1505                 1510                 1515             


Ala Glu  Asp Thr Asp Arg Glu  Thr Val Ala Gly Ile  Pro Asn Lys 
    1520                 1525                 1530             


Val Gly  Val Arg Ile Val Thr  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1535                 1540                 1545             


Cys Ser  Ala Thr Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1550                 1555                 1560             


Thr Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1565                 1570                 1575             


Gln His  Pro Pro Thr Tyr Val  Gln Asn Val Val Pro  Gln Asn Thr 
    1580                 1585                 1590             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1595                 1600                 1605             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1610                 1615                 1620             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1625                 1630                 1635             


Cys Lys  Lys Trp Phe Gln Thr  Pro Ser Gln Val Phe  Tyr His Ala 
    1640                 1645                 1650             


Ala Thr  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1655                 1660                 1665             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1670                 1675                 1680             


Thr His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1685                 1690                 1695             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1700                 1705                 1710             


Ser Thr  Lys Gln Pro Thr Val  Gly Gly Thr Ser Ser  Thr Pro Arg 
    1715                 1720                 1725             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1730                 1735                 1740             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Thr Asp 
    1745                 1750                 1755             


Glu Lys  Glu Gly Pro Ile Thr  Lys His Ile Arg Leu  Thr Ala Ala 
    1760                 1765                 1770             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1775                 1780                 1785             


Leu Leu  Lys Arg His Glu Asn  Asn Leu Ser Val Leu  Ala Ile Ser 
    1790                 1795                 1800             


Asn Met  Glu Ala Ser Ser Thr  Leu Ala Lys Cys Leu  Tyr Glu Leu 
    1805                 1810                 1815             


Asn Phe  Thr Val Gln Ser Lys  Glu Gln Glu Lys Asp  Ser Glu Met 
    1820                 1825                 1830             


Leu Gln  
    1835 


<210>  8
<211>  1788
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Asn Ser Thr Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Thr Arg Val Thr Thr Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Thr Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Thr Leu Gly Ser Phe Ser Thr Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Thr Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Thr Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Thr Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Thr Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Thr Thr 
            340                 345                 350         


His Leu Met Phe His Thr Val Thr Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Thr Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Thr Leu Glu Val Leu Tyr Met Leu Thr Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Thr Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Thr Gln Thr His Val Ala 
                485                 490                 495     


Ser Ala Pro Ala Ser Arg Ala Val Val Ala Gln His Val Ala Pro Pro 
            500                 505                 510         


Pro Gly Ile Val Glu Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu 
        515                 520                 525             


Asn Ala His Phe Glu Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu 
    530                 535                 540                 


Met Tyr Ser Glu Tyr Leu Ser Thr Cys Ser Lys Leu Ala Arg Gly Gly 
545                 550                 555                 560 


Ile Leu Thr Ser Thr Gly Phe Tyr Lys Cys Leu Arg Thr Val Phe Pro 
                565                 570                 575     


Asn His Thr Val Lys Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala 
            580                 585                 590         


His Ile His Val Val Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile 
        595                 600                 605             


Gln Met Tyr Tyr Gln Gln Gln Pro Val Ser Thr Ser Val Val Arg Val 
    610                 615                 620                 


Asp Ser Val Pro Asp Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro 
625                 630                 635                 640 


His Gly Ser Gln Thr Ile Gly Asn His Phe Gln Arg Thr Pro Val Ala 
                645                 650                 655     


Asn Gln Ser Ser Asn Leu Thr Ala Thr Gln Met Ser Phe Pro Val Gln 
            660                 665                 670         


Gly Val His Thr Val Ala Gln Thr Val Ser Arg Ile Pro Gln Asn Pro 
        675                 680                 685             


Ser Pro His Thr His Gln Gln Gln Asn Ala Pro Val Thr Val Ile Gln 
    690                 695                 700                 


Ser Lys Ala Pro Ile Pro Cys Glu Val Val Lys Ala Thr Val Ile Gln 
705                 710                 715                 720 


Asn Ser Ile Pro Gln Thr Gly Val Pro Val Ser Ile Ala Val Gly Gly 
                725                 730                 735     


Gly Pro Pro Gln Ser Ser Val Val Gln Asn His Ser Thr Gly Pro Gln 
            740                 745                 750         


Pro Val Thr Val Val Asn Ser Gln Thr Leu Leu His His Pro Ser Val 
        755                 760                 765             


Ile Pro Gln Gln Ser Pro Leu His Thr Val Val Pro Gly Gln Ile Pro 
    770                 775                 780                 


Ser Gly Thr Pro Val Thr Val Ile Gln Gln Ala Val Pro Gln Ser His 
785                 790                 795                 800 


Met Phe Gly Arg Val Gln Asn Ile Pro Ala Cys Thr Ser Thr Val Ser 
                805                 810                 815     


Gln Gly Gln Gln Leu Ile Thr Thr Ser Pro Gln Pro Val Gln Thr Ser 
            820                 825                 830         


Ser Gln Gln Thr Ser Ala Gly Ser Gln Ser Gln Asp Thr Val Ile Ile 
        835                 840                 845             


Ala Pro Pro Gln Tyr Val Thr Thr Ser Ala Ser Asn Ile Val Ser Ala 
    850                 855                 860                 


Thr Ser Val Gln Asn Phe Gln Val Ala Thr Gly Gln Met Val Thr Ile 
865                 870                 875                 880 


Ala Gly Val Pro Ser Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile 
                885                 890                 895     


Ala Pro Lys Pro Leu Pro Ser Gln Gln Val Ser Ser Thr Val Val Gln 
            900                 905                 910         


Gln Pro Ile Gln Gln Pro Gln Gln Pro Thr Gln Gln Ser Val Val Ile 
        915                 920                 925             


Val Ser Gln Pro Ala Gln Gln Gly Gln Thr Tyr Ala Pro Ala Ile His 
    930                 935                 940                 


Gln Ile Val Leu Ala Asn Pro Ala Ala Leu Pro Ala Gly Gln Thr Val 
945                 950                 955                 960 


Gln Leu Thr Gly Gln Pro Asn Ile Thr Pro Ser Ser Ser Pro Ser Pro 
                965                 970                 975     


Val Pro Ala Thr Asn Asn Gln Val Pro Thr Ala Met Ser Ser Ser Ser 
            980                 985                 990         


Thr Pro Gln Ser Gln Gly Pro Pro  Pro Thr Val Ser Gln  Met Leu Ser 
        995                 1000                 1005             


Val Lys  Arg Gln Gln Gln Gln  Gln His Ser Pro Ala  Pro Pro Pro 
    1010                 1015                 1020             


Gln Gln  Val Gln Val Gln Val  Gln Gln Pro Gln Gln  Val Gln Met 
    1025                 1030                 1035             


Gln Val  Gln Pro Gln Gln Ser  Asn Ala Gly Val Gly  Gln Pro Ala 
    1040                 1045                 1050             


Ser Gly  Glu Ser Ser Leu Ile  Lys Gln Leu Leu Leu  Pro Lys Arg 
    1055                 1060                 1065             


Gly Pro  Ser Thr Pro Gly Gly  Lys Leu Ile Leu Pro  Ala Pro Gln 
    1070                 1075                 1080             


Ile Pro  Pro Pro Asn Asn Ala  Arg Ala Pro Ser Pro  Gln Val Val 
    1085                 1090                 1095             


Tyr Gln  Val Ala Ser Asn Gln  Ala Ala Gly Phe Gly  Val Gln Gly 
    1100                 1105                 1110             


Gln Thr  Pro Ala Gln Gln Leu  Leu Val Gly Gln Gln  Asn Val Gln 
    1115                 1120                 1125             


Leu Val  Pro Ser Ala Met Pro  Pro Ser Gly Gly Val  Gln Thr Val 
    1130                 1135                 1140             


Pro Ile  Ser Asn Leu Gln Ile  Leu Pro Gly Pro Leu  Ile Ser Asn 
    1145                 1150                 1155             


Ser Pro  Ala Thr Ile Phe Gln  Gly Thr Ser Gly Asn  Gln Val Thr 
    1160                 1165                 1170             


Ile Thr  Val Val Pro Asn Thr  Ser Phe Ala Pro Ala  Thr Val Ser 
    1175                 1180                 1185             


Gln Gly  Asn Ala Thr Gln Leu  Ile Ala Pro Ala Gly  Ile Thr Met 
    1190                 1195                 1200             


Ser Gly  Thr Gln Thr Gly Val  Gly Leu Pro Val Gln  Thr Leu Pro 
    1205                 1210                 1215             


Ala Thr  Gln Ala Ser Pro Ala  Gly Gln Ser Ser Cys  Thr Thr Ala 
    1220                 1225                 1230             


Thr Pro  Pro Phe Lys Gly Asp  Lys Ile Ile Cys Gln  Lys Glu Glu 
    1235                 1240                 1245             


Glu Ala  Lys Glu Ala Thr Gly  Leu His Val His Glu  Arg Lys Ile 
    1250                 1255                 1260             


Glu Val  Met Glu Asn Pro Ser  Cys Arg Arg Gly Ala  Thr Asn Thr 
    1265                 1270                 1275             


Ser Asn  Gly Asp Thr Lys Glu  Asn Glu Met His Val  Gly Ser Leu 
    1280                 1285                 1290             


Leu Asn  Gly Arg Lys Tyr Ser  Asp Ser Ser Leu Pro  Pro Ser Asn 
    1295                 1300                 1305             


Ser Gly  Lys Ile Gln Ser Glu  Thr Asn Gln Cys Ser  Leu Ile Ser 
    1310                 1315                 1320             


Asn Gly  Pro Ser Leu Glu Leu  Gly Glu Asn Gly Ala  Ser Gly Lys 
    1325                 1330                 1335             


Gln Asn  Ser Glu Gln Ile Asp  Met Gln Asp Ile Lys  Ser Asp Leu 
    1340                 1345                 1350             


Arg Lys  Pro Leu Val Asn Gly  Ile Cys Asp Phe Asp  Lys Gly Asp 
    1355                 1360                 1365             


Gly Ser  His Leu Ser Lys Asn  Ile Pro Asn His Lys  Thr Ser Asn 
    1370                 1375                 1380             


His Val  Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Thr 
    1385                 1390                 1395             


Leu Asp  Ile Thr Gln Gln Asp  Thr Ala Lys Gly Asp  Gln Leu Glu 
    1400                 1405                 1410             


Arg Ile  Ser Asn Gly Pro Val  Leu Thr Leu Gly Gly  Ser Ser Val 
    1415                 1420                 1425             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Thr Gln  Gln Phe Ser 
    1430                 1435                 1440             


Gly Thr  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1445                 1450                 1455             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1460                 1465                 1470             


Thr Thr  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1475                 1480                 1485             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1490                 1495                 1500             


Arg Ser  Thr Asn Gly Thr Ala  Glu Cys Lys Thr Val  Lys Arg Pro 
    1505                 1510                 1515             


Ala Glu  Asp Thr Asp Arg Glu  Thr Val Ala Gly Ile  Pro Asn Lys 
    1520                 1525                 1530             


Val Gly  Val Arg Ile Val Thr  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1535                 1540                 1545             


Cys Ser  Ala Thr Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1550                 1555                 1560             


Thr Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1565                 1570                 1575             


Gln His  Pro Pro Thr Tyr Val  Gln Asn Val Val Pro  Gln Asn Thr 
    1580                 1585                 1590             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1595                 1600                 1605             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1610                 1615                 1620             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1625                 1630                 1635             


Cys Lys  Lys Trp Phe Gln Thr  Pro Ser Gln Val Phe  Tyr His Ala 
    1640                 1645                 1650             


Ala Thr  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1655                 1660                 1665             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1670                 1675                 1680             


Thr His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1685                 1690                 1695             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1700                 1705                 1710             


Ser Thr  Lys Gln Pro Thr Val  Gly Gly Thr Ser Ser  Thr Pro Arg 
    1715                 1720                 1725             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1730                 1735                 1740             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Thr Asp 
    1745                 1750                 1755             


Glu Lys  Glu Gly Pro Ile Thr  Lys His Ile Arg Leu  Thr Ala Ala 
    1760                 1765                 1770             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1775                 1780                 1785             


<210>  9
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  10
<211>  1045
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Ala Lys Val Arg Pro Ser Arg Arg Ser Arg Ala Gln Arg Asp 
1               5                   10                  15      


Arg Gly Arg Arg Arg Glu Ala Ala Arg Asp Ala Arg Ala Gln Ser Pro 
            20                  25                  30          


Ser Ser Gly Asp Glu Pro Glu Pro Ser Pro Gly Lys Glu Asn Ala Gly 
        35                  40                  45              


Leu Arg Gly Ala Pro Pro Arg Gly Ala Ala Pro Ala Pro Arg Thr Ala 
    50                  55                  60                  


Arg Pro Pro Arg Arg Arg Arg Arg Glu Ser Ser Ser Gln Glu Glu Glu 
65                  70                  75                  80  


Val Ile Asp Gly Phe Ala Ile Ala Ser Phe Ser Thr Leu Glu Ala Leu 
                85                  90                  95      


Glu Lys Asp Met Ala Leu Lys Pro His Glu Arg Lys Glu Lys Trp Glu 
            100                 105                 110         


Arg Arg Leu Ile Lys Lys Pro Arg Glu Ser Glu Thr Cys Pro Pro Ala 
        115                 120                 125             


Glu Pro Ser Glu Asn Arg Arg Pro Leu Glu Ala Gly Ser Pro Gly Gln 
    130                 135                 140                 


Asp Leu Glu Pro Ala Cys Asp Gly Ala Arg Lys Val Pro Leu Gln Pro 
145                 150                 155                 160 


Ser Lys Gln Met Lys Val Thr Val Ser Lys Gly Gly Asp Arg Asp Ser 
                165                 170                 175     


Asp Asp Asp Ser Val Leu Glu Ala Thr Ser Ser Arg Asp Pro Leu Ser 
            180                 185                 190         


Asp Ser Ser Ala His Ala Val Ser Gly Arg Gly Tyr Ser Cys Asp Ser 
        195                 200                 205             


Glu Ser Gly Pro Asp Asp Lys Ala Ser Val Gly Ser Glu Lys Leu Phe 
    210                 215                 220                 


Ala Pro Gly Thr Asp Lys Gly Pro Ala Leu Glu Lys Ser Glu Ala Lys 
225                 230                 235                 240 


Ala Gly Pro Val Pro Lys Val Ser Gly Leu Glu Arg Ser Arg Glu Leu 
                245                 250                 255     


Ser Ala Glu Ser Phe Leu Pro Thr Ala Ser Pro Ala Pro His Ala Ala 
            260                 265                 270         


Pro Cys Pro Gly Pro Pro Pro Gly Ser Arg Ala Asn Pro Leu Val Lys 
        275                 280                 285             


Lys Glu Pro Pro Ala Pro His Arg His Thr Pro Gln Pro Pro Pro Pro 
    290                 295                 300                 


Gln Pro Arg Gly Leu Leu Pro Thr His Val Pro Ala Ser Leu Gly Ala 
305                 310                 315                 320 


Phe Ala Gly His Ser Gln Ala Ala Ala Asn Gly Leu His Gly Leu Ser 
                325                 330                 335     


Arg Ser Ser Ser Ala Pro Leu Gly Leu Gly Lys His Val Ser Leu Ser 
            340                 345                 350         


Pro His Gly Pro Gly Pro His Leu Ser Thr Ser His Leu Ala Leu Arg 
        355                 360                 365             


Ser Gln Ala Gln His Gln Leu His Ala Ala Met Phe Ala Ala Pro Pro 
    370                 375                 380                 


Thr Leu Pro Pro Pro Pro Ala Leu Pro Ala Ser Ser Leu Val Leu Pro 
385                 390                 395                 400 


Gly His Pro Ala Asp His Glu Leu Leu Arg Gln Glu Leu Asn Thr Arg 
                405                 410                 415     


Phe Leu Val Gln Ser Ala Glu Arg Pro Gly Ala Ser Leu Gly Pro Gly 
            420                 425                 430         


Ala Leu Leu Arg Ala Glu Phe His Gln His Gln His Thr His Gln His 
        435                 440                 445             


Thr His Gln His Thr His Gln His Gln His Thr Phe Ala Pro Phe Pro 
    450                 455                 460                 


Ala Gly Leu Pro Pro Thr Pro Pro Ala Ala Pro Pro Pro Phe Asp Lys 
465                 470                 475                 480 


Tyr Ala Pro Lys Leu Asp Ser Pro Tyr Phe Arg His Ser Ser Val Ser 
                485                 490                 495     


Phe Phe Pro Ser Phe Pro Pro Ala Ile Pro Gly Leu Pro Thr Leu Leu 
            500                 505                 510         


Pro His Pro Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln Pro Lys 
        515                 520                 525             


Val Ser Asp Pro Tyr Arg Ala Val Val Lys Val Ser Thr Cys Trp Glu 
    530                 535                 540                 


Gly Pro Trp Gln Gly Arg Thr Leu Val Pro Pro Gly Arg Pro Arg Gly 
545                 550                 555                 560 


Ala Arg Asp Ser Arg Ser Leu Gln Lys Thr Trp Val Gly Val Ala Pro 
                565                 570                 575     


Ala Pro Leu Ser Ala Ser Ile Leu Ser Gln Lys Pro Gly Arg Trp Cys 
            580                 585                 590         


Ala Val His Val Gln Ile Ala Trp Gln Ile Tyr Arg His Gln Gln Lys 
        595                 600                 605             


Ile Lys Glu Met Gln Leu Asp Pro His Lys Leu Glu Val Gly Ala Lys 
    610                 615                 620                 


Leu Asp Leu Phe Gly Arg Pro Pro Ala Pro Gly Val Phe Ala Gly Phe 
625                 630                 635                 640 


His Tyr Pro Gln Asp Leu Ala Arg Pro Leu Phe Pro Ser Thr Gly Ala 
                645                 650                 655     


Ala His Pro Ala Ser Asn Pro Phe Gly Pro Ser Ala His Pro Gly Ser 
            660                 665                 670         


Phe Leu Pro Thr Gly Pro Leu Thr Asp Pro Phe Ser Arg Pro Ser Thr 
        675                 680                 685             


Phe Gly Gly Leu Gly Ser Leu Ser Ser His Ala Phe Gly Gly Leu Gly 
    690                 695                 700                 


Ser His Ala Leu Ala Pro Gly Gly Ser Ile Phe Ala Pro Lys Glu Gly 
705                 710                 715                 720 


Ser Ser Val His Gly Leu Pro Ser Pro His Glu Ala Trp Asn Arg Leu 
                725                 730                 735     


His Arg Ala Pro Pro Ser Phe Pro Ala Pro Pro Pro Trp Pro Lys Ser 
            740                 745                 750         


Val Asp Ala Glu Arg Val Ser Ala Leu Thr Asn His Asp Arg Glu Pro 
        755                 760                 765             


Asp Asn Gly Lys Glu Glu Gln Glu Arg Asp Leu Leu Glu Lys Thr Arg 
    770                 775                 780                 


Leu Leu Ser Arg Ala Ser Pro Ala Thr Pro Ala Gly His Pro Val Ser 
785                 790                 795                 800 


Gly Leu Leu Leu Arg Ala Gln Ser Glu Leu Gly Arg Ser Gly Ala Pro 
                805                 810                 815     


Ala Glu Arg Glu Ala Glu Pro Arg Val Lys Glu Ser Arg Ser Pro Ala 
            820                 825                 830         


Lys Glu Glu Ala Ala Lys Met Pro Ala Arg Ala Ser Pro Pro His Ser 
        835                 840                 845             


Lys Ala Ala Pro Gly Asp Val Lys Val Lys Glu Glu Arg Gly Glu Asp 
    850                 855                 860                 


Glu Ala Ser Glu Pro Pro Ala Gly Gly Leu His Pro Ala Pro Leu Gln 
865                 870                 875                 880 


Leu Gly Leu Gly Arg Glu Arg Leu Gly Ala Pro Gly Phe Ala Trp Glu 
                885                 890                 895     


Pro Phe Arg Gly Leu Glu Leu Pro Arg Arg Ala Phe Pro Ala Ala Ala 
            900                 905                 910         


Pro Ala Pro Gly Ser Ala Ala Leu Leu Glu Pro Pro Glu Arg Pro Tyr 
        915                 920                 925             


Arg Asp Arg Glu Pro His Gly Tyr Ser Pro Glu Arg Leu Arg Gly Glu 
    930                 935                 940                 


Leu Glu Arg Ala Arg Ala Pro His Leu Pro Pro Ala Ala Pro Ala Leu 
945                 950                 955                 960 


Asp Gly Ala Leu Leu Pro Ser Leu Gly Ala Leu His Phe Pro Arg Leu 
                965                 970                 975     


Ser Pro Ala Ala Leu His Asn Gly Leu Leu Ala Arg Thr Pro Pro Ala 
            980                 985                 990         


Ala Ala Ala Leu Gly Ala Pro Pro  Pro Leu Val Thr Ala  Ala Gly Pro 
        995                 1000                 1005             


Pro Thr  Pro Pro Gly Pro Pro  Arg Ser Arg Thr Thr  Pro Leu Gly 
    1010                 1015                 1020             


Gly Leu  Gly Pro Gly Glu Ala  Arg Asp Tyr Ser Pro  Ser Arg Asn 
    1025                 1030                 1035             


Pro Pro  Glu Val Glu Ala Arg  
    1040                 1045 


<210>  11
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Val Leu Val Leu Arg Leu Thr Val Val Leu Gly Leu Leu Val 
1               5                   10                  15      


Leu Phe Leu Thr Cys Tyr Ala Asp Asp Lys Pro Asp Lys Pro Asp Asp 
            20                  25                  30          


Lys Pro Asp Asp Ser Gly Lys Asp Pro Lys Pro Asp Phe Pro Lys Phe 
        35                  40                  45              


Leu Ser Leu Leu Gly Thr Glu Ile Ile Glu Asn Ala Val Glu Phe Ile 
    50                  55                  60                  


Leu Arg Ser Met Ser Arg Ser Thr Gly Phe Met Glu Phe Asp Asp Asn 
65                  70                  75                  80  


Glu Gly Lys His Ser Ser Lys 
                85          


<210>  12
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Val Ser Ser Ala 
1               5                   10                  15      


Gly Thr Ser Ala His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp 
        35                  40                  45              


Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro 
                85                  90                  95      


Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn Ala 
            100                 105                 110         


Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Val Pro Lys Ile Ala 
        115                 120                 125             


Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val Leu Lys 
    130                 135                 140                 


Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr 
145                 150                 155                 160 


Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His 
                165                 170                 175     


Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys 
            180                 185                 190         


Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln 
        195                 200                 205             


Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly 
    210                 215                 220                 


Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn 
225                 230                 235                 240 


Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala Asp 
                245                 250                 255 


<210>  13
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Ile 
        195                 200                 205             


Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys 
    210                 215                 220                 


Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn 
225                 230                 235                 240 


Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser 
                245                 250                 255     


Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala 
            260                 265                 270         


Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg 
        275                 280                 285             


Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln 
    290                 295                 300                 


Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg 
305                 310                 315                 320 


Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala 
                325                 330                 335     


Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu 
            340                 345                 350         


Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro 
        355                 360                 365             


Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro 
    370                 375                 380                 


Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys 
385                 390                 395                 400 


Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile 
                405                 410                 415     


Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu 
            420                 425                 430         


Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro 
        435                 440                 445             


Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly 
    450                 455                 460                 


Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr 
465                 470                 475                 480 


Ala Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr 
                485                 490                 495     


Lys Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu 
            500                 505                 510         


Arg Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser 
        515                 520                 525             


Val Asp Lys Val Thr Ser Pro Thr Lys Val 
    530                 535             


<210>  14
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  15
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro Ser Thr 
            340                 345                 350         


Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val Gly Ala 
        355                 360                 365             


Glu Arg Arg Pro Arg Pro Thr Thr Val Thr Ala Val His Ser Gly Ser 
    370                 375                 380                 


Lys 
385 


<210>  16
<211>  354
<212>  PRT
<213>  Mus musculus

<400>  16

Met Pro His Arg Ser Leu Arg Ala Thr Val Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Lys Gln Pro Ser Ser Ser Ala Pro Leu Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Val Gly Pro Ala Gly Glu Lys Asn Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Ala Pro Leu Gln Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Val Ser Val Glu Lys Leu Leu Asn Leu Thr Asn Asp Gly His Ser Val 
                85                  90                  95      


Arg Leu Asn Leu Asn Ser Asp Met Tyr Ile Gln Gly Leu Gln Pro His 
            100                 105                 110         


His Tyr Arg Ala Glu Gln Leu His Leu His Trp Gly Asn Arg Asn Asp 
        115                 120                 125             


Pro His Gly Ser Glu His Thr Val Ser Gly Lys His Phe Ala Ala Glu 
    130                 135                 140                 


Leu His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Phe Ser Thr 
145                 150                 155                 160 


Ala Ser Asp Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu 
                165                 170                 175     


Ile Gly Ser Ala Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln 
            180                 185                 190         


His Val Lys Tyr Lys Gly Gln Gln Val Leu Ile Pro Gly Phe Asn Ile 
        195                 200                 205             


Glu Glu Leu Leu Pro Glu Ser Pro Gly Glu Tyr Tyr Arg Tyr Glu Gly 
    210                 215                 220                 


Ser Leu Thr Thr Pro Pro Cys Tyr Pro Thr Val Leu Trp Thr Val Phe 
225                 230                 235                 240 


Arg Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr 
                245                 250                 255     


Ala Leu Tyr Phe Thr His Met Asp Asp Pro Thr Pro Arg Glu Met Ile 
            260                 265                 270         


Asn Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Ile 
        275                 280                 285             


Ser Phe Arg Gln Gly Leu Leu Thr Asp Thr Gly Leu Ser Leu Gly Ile 
    290                 295                 300                 


Ile Leu Ser Val Ala Leu Ala Gly Val Leu Gly Ile Ser Ile Val Leu 
305                 310                 315                 320 


Ala Val Ser Ile Trp Leu Phe Lys Arg Lys Lys Ser Lys Lys Gly Asp 
                325                 330                 335     


Asn Lys Gly Val Ile Tyr Lys Pro Ala Ile Lys Lys Glu Ala Glu Val 
            340                 345                 350         


His Ala 
        


<210>  17
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Ala Trp Arg Ser Ala Phe Leu Val Cys Leu Ala Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Ser Gly Asp Phe Asp Asp Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Val Lys Glu Thr Ser Ser Val Lys Gln Pro Trp Asp His 
        35                  40                  45              


Thr Thr Thr Thr Thr Thr Asn Arg Pro Gly Thr Thr Arg Ala Pro Ala 
    50                  55                  60                  


Lys Pro Pro Gly Ser Gly Leu Asp Leu Ala Asp Ala Leu Asp Asp Gln 
65                  70                  75                  80  


Asp Asp Gly Arg Arg Lys Pro Gly Ile Gly Gly Arg Glu Arg Trp Asn 
                85                  90                  95      


His Val Thr Thr Thr Thr Lys Arg Pro Val Thr Thr Arg Ala Pro Ala 
            100                 105                 110         


Asn Thr Leu Gly Asn Asp Phe Asp Leu Ala Asp Ala Leu Asp Asp Arg 
        115                 120                 125             


Asn Asp Arg Asp Asp Gly Arg Arg Lys Pro Ile Ala Gly Gly Gly Gly 
    130                 135                 140                 


Phe Ser Asp Lys Asp Leu Glu Asp Ile Val Gly Gly Gly Glu Tyr Lys 
145                 150                 155                 160 


Pro Asp Lys Gly Lys Gly Asp Gly Arg Tyr Gly Ser Asn Asp Asp Pro 
                165                 170                 175     


Gly Ser Gly Met Val Ala Glu Pro Gly Thr Ile Ala Gly Val Ala Ser 
            180                 185                 190         


Ala Leu Ala Met Ala Leu Ile Gly Ala Val Ser Ser Tyr Ile Ser Tyr 
        195                 200                 205             


Gln Gln Lys Lys Phe Cys Phe Ser Ile Gln Gln Gly Leu Asn Ala Asp 
    210                 215                 220                 


Tyr Val Lys Gly Glu Asn Leu Glu Ala Val Val Cys Glu Glu Pro Gln 
225                 230                 235                 240 


Val Lys Tyr Ser Thr Leu His Thr Gln Ser Ala Glu Pro Pro Pro Pro 
                245                 250                 255     


Pro Glu Pro Ala Arg Ile 
            260         


<210>  18
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  19
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  20
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Arg Gln Asn Leu Thr Met Leu Pro Arg Leu Asp Ser Asn Ser Trp Ala 
                325                 330                 335     


Gln Ala Ile Leu Pro Ser Val Ser Gln Ser Ala Glu Ile Thr Asp Asn 
            340                 345                 350         


Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile 
        355                 360                 365             


Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala 
    370                 375                 380                 


Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp 
385                 390                 395                 400 


Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser 
                405                 410                 415     


Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn 
            420                 425                 430         


Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu 
        435                 440                 445             


Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
    450                 455                 460     


<210>  21
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
        355                 360                 365             


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
    370                 375                 380                 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
385                 390                 395                 400 


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
                405                 410                 415     


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
            420                 425                 430 


<210>  22
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
        355                 360                 365             


<210>  23
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Thr Thr Pro Met Thr 
    450                 455                 460                 


His Leu Thr Arg 
465             


<210>  24
<211>  1899
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Gly Met Glu Cys Leu Thr Arg Ala 
            20                  25                  30          


Glu Ala Asp Ile Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg 
        35                  40                  45              


Ala Asn Phe Arg Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val 
    50                  55                  60                  


Phe Asp Ile Gly Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser 
65                  70                  75                  80  


Gly Asp Pro Arg Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys 
                85                  90                  95      


Ser Leu Leu Gln Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr 
            100                 105                 110         


Leu Thr Gly Met Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr 
        115                 120                 125             


Gln Ala Gly Met Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr 
    130                 135                 140                 


Asp Gly Lys Ser Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys 
145                 150                 155                 160 


Asp Glu Gly Val Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu 
                165                 170                 175     


Val Glu Leu Lys Met Ile Ala Thr Asp Pro Asp Asp Thr His Ala Tyr 
            180                 185                 190         


Asn Val Ala Asp Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr 
        195                 200                 205             


Ile Asn Leu Cys Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro 
    210                 215                 220                 


Ser Asn Leu Val Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser 
225                 230                 235                 240 


Trp Thr Pro Pro Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr 
                245                 250                 255     


Pro Val Ser Gly Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu 
            260                 265                 270         


Thr Ser Thr Val Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val 
        275                 280                 285             


Asn Val Tyr Ser Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly 
    290                 295                 300                 


Thr Glu Lys Thr Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp 
305                 310                 315                 320 


Val Gly Pro Thr Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala 
                325                 330                 335     


Thr Gly Tyr Ile Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr 
            340                 345                 350         


Arg Pro Lys Glu Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu 
        355                 360                 365             


Thr Asp Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val 
    370                 375                 380                 


Leu His Asp Leu Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu 
385                 390                 395                 400 


Pro Leu Pro Arg Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser 
                405                 410                 415     


Thr Met Asn Val Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr 
            420                 425                 430         


Ile Val Arg Tyr Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val 
        435                 440                 445             


Asp Arg Ser Glu Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr 
    450                 455                 460                 


Leu Tyr Thr Val Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro 
465                 470                 475                 480 


Pro Val Thr Ala Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn 
                485                 490                 495     


Leu Lys Ile Thr Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp 
            500                 505                 510         


His Gly Ala Ser Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala Pro Phe 
        515                 520                 525             


Gly Ser Ser Asp Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr 
    530                 535                 540                 


Leu Val Phe Glu Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile 
545                 550                 555                 560 


Thr Ala Ile Tyr Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser 
                565                 570                 575     


Glu Arg Thr Leu Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro 
            580                 585                 590         


Arg Asn Leu Gln Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys 
        595                 600                 605             


Trp Asp Pro Ala Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln 
    610                 615                 620                 


Pro Ser Thr Gly Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg 
625                 630                 635                 640 


Gln Asn Ser Val Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr 
                645                 650                 655     


Ile Thr Val Ser Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr 
            660                 665                 670         


Gly Arg Gly Lys Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val 
        675                 680                 685             


Tyr Asp Pro Ser Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu 
    690                 695                 700                 


Gly Asn Pro Arg Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly 
705                 710                 715                 720 


Pro Glu Glu Leu Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu 
                725                 730                 735     


Arg Asn Leu Gln Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val 
            740                 745                 750         


Tyr Thr Glu Gly Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu 
        755                 760                 765             


Met Arg Gly Leu Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn 
    770                 775                 780                 


Ser Leu Asp Val Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr 
785                 790                 795                 800 


Arg Val Val Tyr Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile 
                805                 810                 815     


Val Val Pro Gly Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro 
            820                 825                 830         


Asp Thr Leu Tyr Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu 
        835                 840                 845             


Gly Asn Pro Ser Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro 
    850                 855                 860                 


Arg Asn Leu Arg Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala 
865                 870                 875                 880 


Trp Asp His Ala Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser 
                885                 890                 895     


Pro Thr Val Gly Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg 
            900                 905                 910         


Arg Asn Asn Val Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys 
        915                 920                 925             


Ile Thr Val Ile Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr 
    930                 935                 940                 


Gly Asn Gly Arg Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile 
945                 950                 955                 960 


Ser Asp Glu Trp Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro 
                965                 970                 975     


Ser Pro Val Leu Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn 
            980                 985                 990         


Glu Pro Met Glu Ala Phe Val Gly  Glu Met Thr Ser Tyr  Thr Leu His 
        995                 1000                 1005             


Asn Leu  Asn Pro Ser Thr Thr  Tyr Asp Val Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Tyr Asp  Ser Gly Leu Ser Val  Pro Leu Thr Asp Gln  Gly Thr Thr 
    1025                 1030                 1035             


Leu Tyr  Leu Asn Val Thr Asp  Leu Lys Thr Tyr Gln  Ile Gly Trp 
    1040                 1045                 1050             


Asp Thr  Phe Cys Val Lys Trp  Ser Pro His Arg Ala  Ala Thr Ser 
    1055                 1060                 1065             


Tyr Arg  Leu Lys Leu Ser Pro  Ala Asp Gly Thr Arg  Gly Gln Glu 
    1070                 1075                 1080             


Ile Thr  Val Arg Gly Ser Glu  Thr Ser His Cys Phe  Thr Gly Leu 
    1085                 1090                 1095             


Ser Pro  Asp Thr Asp Tyr Gly  Val Thr Val Phe Val  Gln Thr Pro 
    1100                 1105                 1110             


Asn Leu  Glu Gly Pro Gly Val  Ser Val Lys Glu His  Thr Thr Val 
    1115                 1120                 1125             


Lys Pro  Thr Glu Ala Pro Thr  Glu Pro Pro Thr Pro  Pro Pro Pro 
    1130                 1135                 1140             


Pro Thr  Ile Pro Pro Ala Arg  Asp Val Cys Lys Gly  Ala Lys Ala 
    1145                 1150                 1155             


Asp Ile  Val Phe Leu Thr Asp  Ala Ser Trp Ser Ile  Gly Asp Asp 
    1160                 1165                 1170             


Asn Phe  Asn Lys Val Val Lys  Phe Ile Phe Asn Thr  Val Gly Gly 
    1175                 1180                 1185             


Phe Asp  Glu Ile Ser Pro Ala  Gly Ile Gln Val Ser  Phe Val Gln 
    1190                 1195                 1200             


Tyr Ser  Asp Glu Val Lys Ser  Glu Phe Lys Leu Asn  Thr Tyr Asn 
    1205                 1210                 1215             


Asp Lys  Ala Leu Ala Leu Gly  Ala Leu Gln Asn Ile  Arg Tyr Arg 
    1220                 1225                 1230             


Gly Gly  Asn Thr Arg Thr Gly  Lys Ala Leu Thr Phe  Ile Lys Glu 
    1235                 1240                 1245             


Lys Val  Leu Thr Trp Glu Ser  Gly Met Arg Lys Asn  Val Pro Lys 
    1250                 1255                 1260             


Val Leu  Val Val Val Thr Asp  Gly Arg Ser Gln Asp  Glu Val Lys 
    1265                 1270                 1275             


Lys Ala  Ala Leu Val Ile Gln  Gln Ser Gly Phe Ser  Val Phe Val 
    1280                 1285                 1290             


Val Gly  Val Ala Asp Val Asp  Tyr Asn Glu Leu Ala  Asn Ile Ala 
    1295                 1300                 1305             


Ser Lys  Pro Ser Glu Arg His  Val Phe Ile Val Asp  Asp Phe Glu 
    1310                 1315                 1320             


Ser Phe  Glu Lys Ile Glu Asp  Asn Leu Ile Thr Phe  Val Cys Glu 
    1325                 1330                 1335             


Thr Ala  Thr Ser Ser Cys Pro  Leu Ile Tyr Leu Asp  Gly Tyr Thr 
    1340                 1345                 1350             


Ser Pro  Gly Phe Lys Met Leu  Glu Ala Tyr Asn Leu  Thr Glu Lys 
    1355                 1360                 1365             


Asn Phe  Ala Ser Val Gln Gly  Val Ser Leu Glu Ser  Gly Ser Phe 
    1370                 1375                 1380             


Pro Ser  Tyr Ser Ala Tyr Arg  Ile Gln Lys Asn Ala  Phe Val Asn 
    1385                 1390                 1395             


Gln Pro  Thr Ala Asp Leu His  Pro Asn Gly Leu Pro  Pro Ser Tyr 
    1400                 1405                 1410             


Thr Ile  Ile Leu Leu Phe Arg  Leu Leu Pro Glu Thr  Pro Ser Asp 
    1415                 1420                 1425             


Pro Phe  Ala Ile Trp Gln Ile  Thr Asp Arg Asp Tyr  Lys Pro Gln 
    1430                 1435                 1440             


Val Gly  Val Ile Ala Asp Pro  Ser Ser Lys Thr Leu  Ser Phe Phe 
    1445                 1450                 1455             


Asn Lys  Asp Thr Arg Gly Glu  Val Gln Thr Val Thr  Phe Asp Thr 
    1460                 1465                 1470             


Glu Glu  Val Lys Thr Leu Phe  Tyr Gly Ser Phe His  Lys Val His 
    1475                 1480                 1485             


Ile Val  Val Thr Ser Lys Ser  Val Lys Ile Tyr Ile  Asp Cys Tyr 
    1490                 1495                 1500             


Glu Ile  Ile Glu Lys Asp Ile  Lys Glu Ala Gly Asn  Ile Thr Thr 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Ile Leu Gly  Lys Leu Leu Lys Gly  Glu Arg Lys 
    1520                 1525                 1530             


Ser Ala  Ala Phe Gln Ile Gln  Ser Phe Asp Ile Val  Cys Ser Pro 
    1535                 1540                 1545             


Val Trp  Thr Ser Arg Asp Arg  Cys Cys Asp Ile Pro  Ser Arg Arg 
    1550                 1555                 1560             


Asp Glu  Gly Lys Cys Pro Ala  Phe Pro Asn Ser Cys  Thr Cys Thr 
    1565                 1570                 1575             


Gln Asp  Ser Val Gly Pro Pro  Gly Pro Pro Gly Pro  Ala Gly Gly 
    1580                 1585                 1590             


Pro Gly  Ala Lys Gly Pro Arg  Gly Glu Arg Gly Ile  Ser Gly Ala 
    1595                 1600                 1605             


Ile Gly  Pro Pro Gly Pro Arg  Gly Asp Ile Gly Pro  Pro Gly Pro 
    1610                 1615                 1620             


Gln Gly  Pro Pro Gly Pro Gln  Gly Pro Asn Gly Leu  Ser Ile Pro 
    1625                 1630                 1635             


Gly Glu  Gln Gly Arg Gln Gly  Met Lys Gly Asp Ala  Gly Glu Pro 
    1640                 1645                 1650             


Gly Leu  Pro Gly Arg Thr Gly  Thr Pro Gly Leu Pro  Gly Pro Pro 
    1655                 1660                 1665             


Gly Pro  Met Gly Pro Pro Gly  Asp Arg Gly Phe Thr  Gly Lys Asp 
    1670                 1675                 1680             


Gly Ala  Met Gly Pro Arg Gly  Pro Pro Gly Pro Pro  Gly Ser Pro 
    1685                 1690                 1695             


Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly Lys Pro  Gly Lys Pro 
    1700                 1705                 1710             


Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly Leu Lys  Gly Glu Lys 
    1715                 1720                 1725             


Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn Met Met  Arg Ala Val 
    1730                 1735                 1740             


Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser Gly Gln  Met Asn Arg 
    1745                 1750                 1755             


Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn Asp Tyr  Gln Ser Ser 
    1760                 1765                 1770             


Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ser 
    1775                 1780                 1785             


Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly Gly Arg  Pro Gly Phe 
    1790                 1795                 1800             


Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro Gly Glu  Arg Gly Leu 
    1805                 1810                 1815             


Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly Ser Ser  Gly Pro Arg 
    1820                 1825                 1830             


Gly Leu  Pro Gly Pro Gln Gly  Pro Gln Gly Glu Ser  Arg Thr Gly 
    1835                 1840                 1845             


Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1850                 1855                 1860             


Arg Pro  Gly Asn Ser Gly Ile  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1865                 1870                 1875             


Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile Pro Tyr  Asn Gly Gln 
    1880                 1885                 1890             


Ser Tyr  Pro Gly Ser Gly 
    1895                 


<210>  25
<211>  1500
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu Leu Ser Val Lys Ala Gln Thr Ala His Ile 
        35                  40                  45              


Val Leu Glu Asp Gly Thr Lys Met Lys Gly Tyr Ser Phe Gly His Pro 
    50                  55                  60                  


Ser Ser Val Ala Gly Glu Val Val Phe Asn Thr Gly Leu Gly Gly Tyr 
65                  70                  75                  80  


Pro Glu Ala Ile Thr Asp Pro Ala Tyr Lys Gly Gln Ile Leu Thr Met 
                85                  90                  95      


Ala Asn Pro Ile Ile Gly Asn Gly Gly Ala Pro Asp Thr Thr Ala Leu 
            100                 105                 110         


Asp Glu Leu Gly Leu Ser Lys Tyr Leu Glu Ser Asn Gly Ile Lys Val 
        115                 120                 125             


Ser Gly Leu Leu Val Leu Asp Tyr Ser Lys Asp Tyr Asn His Trp Leu 
    130                 135                 140                 


Ala Thr Lys Ser Leu Gly Gln Trp Leu Gln Glu Glu Lys Val Pro Ala 
145                 150                 155                 160 


Ile Tyr Gly Val Asp Thr Arg Met Leu Thr Lys Ile Ile Arg Asp Lys 
                165                 170                 175     


Gly Thr Met Leu Gly Lys Ile Glu Phe Glu Gly Gln Pro Val Asp Phe 
            180                 185                 190         


Val Asp Pro Asn Lys Gln Asn Leu Ile Ala Glu Val Ser Thr Lys Asp 
        195                 200                 205             


Val Lys Val Tyr Gly Lys Gly Asn Pro Thr Lys Val Val Ala Val Asp 
    210                 215                 220                 


Cys Gly Ile Lys Asn Asn Val Ile Arg Leu Leu Val Lys Arg Gly Ala 
225                 230                 235                 240 


Glu Val His Leu Val Pro Trp Asn His Asp Phe Thr Lys Met Glu Tyr 
                245                 250                 255     


Asp Gly Ile Leu Ile Ala Gly Gly Pro Gly Asn Pro Ala Leu Ala Glu 
            260                 265                 270         


Pro Leu Ile Gln Asn Val Arg Lys Ile Leu Glu Ser Asp Arg Lys Glu 
        275                 280                 285             


Pro Leu Phe Gly Ile Ser Thr Gly Asn Leu Ile Thr Gly Leu Ala Ala 
    290                 295                 300                 


Gly Ala Lys Thr Tyr Lys Met Ser Met Ala Asn Arg Gly Gln Asn Gln 
305                 310                 315                 320 


Pro Val Leu Asn Ile Thr Asn Lys Gln Ala Phe Ile Thr Ala Gln Asn 
                325                 330                 335     


His Gly Tyr Ala Leu Asp Asn Thr Leu Pro Ala Gly Trp Lys Pro Leu 
            340                 345                 350         


Phe Val Asn Val Asn Asp Gln Thr Asn Glu Gly Ile Met His Glu Ser 
        355                 360                 365             


Lys Pro Phe Phe Ala Val Gln Phe His Pro Glu Val Thr Pro Gly Pro 
    370                 375                 380                 


Ile Asp Thr Glu Tyr Leu Phe Asp Ser Phe Phe Ser Leu Ile Lys Lys 
385                 390                 395                 400 


Gly Lys Ala Thr Thr Ile Thr Ser Val Leu Pro Lys Pro Ala Leu Val 
                405                 410                 415     


Ala Ser Arg Val Glu Val Ser Lys Val Leu Ile Leu Gly Ser Gly Gly 
            420                 425                 430         


Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly Ser Gln Ala 
        435                 440                 445             


Val Lys Ala Met Lys Glu Glu Asn Val Lys Thr Val Leu Met Asn Pro 
    450                 455                 460                 


Asn Ile Ala Ser Val Gln Thr Asn Glu Val Gly Leu Lys Gln Ala Asp 
465                 470                 475                 480 


Thr Val Tyr Phe Leu Pro Ile Thr Pro Gln Phe Val Thr Glu Val Ile 
                485                 490                 495     


Lys Ala Glu Gln Pro Asp Gly Leu Ile Leu Gly Met Gly Gly Gln Thr 
            500                 505                 510         


Ala Leu Asn Cys Gly Val Glu Leu Phe Lys Arg Gly Val Leu Lys Glu 
        515                 520                 525             


Tyr Gly Val Lys Val Leu Gly Thr Ser Val Glu Ser Ile Met Ala Thr 
    530                 535                 540                 


Glu Asp Arg Gln Leu Phe Ser Asp Lys Leu Asn Glu Ile Asn Glu Lys 
545                 550                 555                 560 


Ile Ala Pro Ser Phe Ala Val Glu Ser Ile Glu Asp Ala Leu Lys Ala 
                565                 570                 575     


Ala Asp Thr Ile Gly Tyr Pro Val Met Ile Arg Ser Ala Tyr Ala Leu 
            580                 585                 590         


Gly Gly Leu Gly Ser Gly Ile Cys Pro Asn Arg Glu Thr Leu Met Asp 
        595                 600                 605             


Leu Ser Thr Lys Ala Phe Ala Met Thr Asn Gln Ile Leu Val Glu Lys 
    610                 615                 620                 


Ser Val Thr Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
625                 630                 635                 640 


Asp Asp Asn Cys Val Thr Val Cys Asn Met Glu Asn Val Asp Ala Met 
                645                 650                 655     


Gly Val His Thr Gly Asp Ser Val Val Val Ala Pro Ala Gln Thr Leu 
            660                 665                 670         


Ser Asn Ala Glu Phe Gln Met Leu Arg Arg Thr Ser Ile Asn Val Val 
        675                 680                 685             


Arg His Leu Gly Ile Val Gly Glu Cys Asn Ile Gln Phe Ala Leu His 
    690                 695                 700                 


Pro Thr Ser Met Glu Tyr Cys Ile Ile Glu Val Asn Ala Arg Leu Ser 
705                 710                 715                 720 


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Phe 
                725                 730                 735     


Ile Ala Ala Lys Ile Ala Leu Gly Ile Pro Leu Pro Glu Ile Lys Asn 
            740                 745                 750         


Val Val Ser Gly Lys Thr Ser Ala Cys Phe Glu Pro Ser Leu Asp Tyr 
        755                 760                 765             


Met Val Thr Lys Ile Pro Arg Trp Asp Leu Asp Arg Phe His Gly Thr 
    770                 775                 780                 


Ser Ser Arg Ile Gly Ser Ser Met Lys Ser Val Gly Glu Val Met Ala 
785                 790                 795                 800 


Ile Gly Arg Thr Phe Glu Glu Ser Phe Gln Lys Ala Leu Arg Met Cys 
                805                 810                 815     


His Pro Ser Ile Glu Gly Phe Thr Pro Arg Leu Pro Met Asn Lys Glu 
            820                 825                 830         


Trp Pro Ser Asn Leu Asp Leu Arg Lys Glu Leu Ser Glu Pro Ser Ser 
        835                 840                 845             


Thr Arg Ile Tyr Ala Ile Ala Lys Ala Ile Asp Asp Asn Met Ser Leu 
    850                 855                 860                 


Asp Glu Ile Glu Lys Leu Thr Tyr Ile Asp Lys Trp Phe Leu Tyr Lys 
865                 870                 875                 880 


Met Arg Asp Ile Leu Asn Met Glu Lys Thr Leu Lys Gly Leu Asn Ser 
                885                 890                 895     


Glu Ser Met Thr Glu Glu Thr Leu Lys Arg Ala Lys Glu Ile Gly Phe 
            900                 905                 910         


Ser Asp Lys Gln Ile Ser Lys Cys Leu Gly Leu Thr Glu Ala Gln Thr 
        915                 920                 925             


Arg Glu Leu Arg Leu Lys Lys Asn Ile His Pro Trp Val Lys Gln Ile 
    930                 935                 940                 


Asp Thr Leu Ala Ala Glu Tyr Pro Ser Val Thr Asn Tyr Leu Tyr Val 
945                 950                 955                 960 


Thr Tyr Asn Gly Gln Glu His Asp Val Asn Phe Asp Asp His Gly Met 
                965                 970                 975     


Met Val Leu Gly Cys Gly Pro Tyr His Ile Gly Ser Ser Val Glu Phe 
            980                 985                 990         


Asp Trp Cys Ala Val Ser Ser Ile  Arg Thr Leu Arg Gln  Leu Gly Lys 
        995                 1000                 1005             


Lys Thr  Val Val Val Asn Cys  Asn Pro Glu Thr Val  Ser Thr Asp 
    1010                 1015                 1020             


Phe Asp  Glu Cys Asp Lys Leu  Tyr Phe Glu Glu Leu  Ser Leu Glu 
    1025                 1030                 1035             


Arg Ile  Leu Asp Ile Tyr His  Gln Glu Ala Cys Gly  Gly Cys Ile 
    1040                 1045                 1050             


Ile Ser  Val Gly Gly Gln Ile  Pro Asn Asn Leu Ala  Val Pro Leu 
    1055                 1060                 1065             


Tyr Lys  Asn Gly Val Lys Ile  Met Gly Thr Ser Pro  Leu Gln Ile 
    1070                 1075                 1080             


Asp Arg  Ala Glu Asp Arg Ser  Ile Phe Ser Ala Val  Leu Asp Glu 
    1085                 1090                 1095             


Leu Lys  Val Ala Gln Ala Pro  Trp Lys Ala Val Asn  Thr Leu Asn 
    1100                 1105                 1110             


Glu Ala  Leu Glu Phe Ala Lys  Ser Val Asp Tyr Pro  Cys Leu Leu 
    1115                 1120                 1125             


Arg Pro  Ser Tyr Val Leu Ser  Gly Ser Ala Met Asn  Val Val Phe 
    1130                 1135                 1140             


Ser Glu  Asp Glu Met Lys Lys  Phe Leu Glu Glu Ala  Thr Arg Val 
    1145                 1150                 1155             


Ser Gln  Glu His Pro Val Val  Leu Thr Lys Phe Val  Glu Gly Ala 
    1160                 1165                 1170             


Arg Glu  Val Glu Met Asp Ala  Val Gly Lys Asp Gly  Arg Val Ile 
    1175                 1180                 1185             


Ser His  Ala Ile Ser Glu His  Val Glu Asp Ala Gly  Val His Ser 
    1190                 1195                 1200             


Gly Asp  Ala Thr Leu Met Leu  Pro Thr Gln Thr Ile  Ser Gln Gly 
    1205                 1210                 1215             


Ala Ile  Glu Lys Val Lys Asp  Ala Thr Arg Lys Ile  Ala Lys Ala 
    1220                 1225                 1230             


Phe Ala  Ile Ser Gly Pro Phe  Asn Val Gln Phe Leu  Val Lys Gly 
    1235                 1240                 1245             


Asn Asp  Val Leu Val Ile Glu  Cys Asn Leu Arg Ala  Ser Arg Ser 
    1250                 1255                 1260             


Phe Pro  Phe Val Ser Lys Thr  Leu Gly Val Asp Phe  Ile Asp Val 
    1265                 1270                 1275             


Ala Thr  Lys Val Met Ile Gly  Glu Asn Val Asp Glu  Lys His Leu 
    1280                 1285                 1290             


Pro Thr  Leu Asp His Pro Ile  Ile Pro Ala Asp Tyr  Val Ala Ile 
    1295                 1300                 1305             


Lys Ala  Pro Met Phe Ser Trp  Pro Arg Leu Arg Asp  Ala Asp Pro 
    1310                 1315                 1320             


Ile Leu  Arg Cys Glu Met Ala  Ser Thr Gly Glu Val  Ala Cys Phe 
    1325                 1330                 1335             


Gly Glu  Gly Ile His Thr Ala  Phe Leu Lys Ala Met  Leu Ser Thr 
    1340                 1345                 1350             


Gly Phe  Lys Ile Pro Gln Lys  Gly Ile Leu Ile Gly  Ile Gln Gln 
    1355                 1360                 1365             


Ser Phe  Arg Pro Arg Phe Leu  Gly Val Ala Glu Gln  Leu His Asn 
    1370                 1375                 1380             


Glu Gly  Phe Lys Leu Phe Ala  Thr Glu Ala Thr Ser  Asp Trp Leu 
    1385                 1390                 1395             


Asn Ala  Asn Asn Val Pro Ala  Thr Pro Val Ala Trp  Pro Ser Gln 
    1400                 1405                 1410             


Glu Gly  Gln Asn Pro Ser Leu  Ser Ser Ile Arg Lys  Leu Ile Arg 
    1415                 1420                 1425             


Asp Gly  Ser Ile Asp Leu Val  Ile Asn Leu Pro Asn  Asn Asn Thr 
    1430                 1435                 1440             


Lys Phe  Val His Asp Asn Tyr  Val Ile Arg Arg Thr  Ala Val Asp 
    1445                 1450                 1455             


Ser Gly  Ile Pro Leu Leu Thr  Asn Phe Gln Val Thr  Lys Leu Phe 
    1460                 1465                 1470             


Ala Glu  Ala Val Gln Lys Ser  Arg Lys Val Asp Ser  Lys Ser Leu 
    1475                 1480                 1485             


Phe His  Tyr Arg Gln Tyr Ser  Ala Gly Lys Ala Ala  
    1490                 1495                 1500 


<210>  26
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Gly Asp 
65                  70                  75                  80  


Gln Arg Gln Val Ile Pro Ile Pro Ser Pro Pro Ala Lys Tyr Leu Leu 
                85                  90                  95      


Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys Cys Val Val Ile Asp 
            100                 105                 110         


Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Ile Ser Asn Ala 
        115                 120                 125             


Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr Ile His Gln Val Tyr 
    130                 135                 140                 


Val Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Gln 
145                 150                 155                 160 


Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp 
                165                 170                 175     


Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val Phe Arg Ala Arg Leu 
            180                 185                 190         


Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu 
        195                 200                 205             


Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile Ile Val Asp Asn Ser 
    210                 215                 220                 


Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala Val Pro Val Gln Ser 
225                 230                 235                 240 


Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu Asp Leu Ile Pro Phe 
                245                 250                 255     


Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr Ser Met Leu His Arg 
            260                 265                 270         


Leu Cys Asn Arg 
        275     


<210>  27
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Pro Pro 
65                  70                  75                  80  


Ala Lys Tyr Leu Leu Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys 
                85                  90                  95      


Cys Val Val Ile Asp Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys 
            100                 105                 110         


Pro Ile Ser Asn Ala Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr 
        115                 120                 125             


Ile His Gln Val Tyr Val Leu Lys Arg Pro His Val Asp Glu Phe Leu 
    130                 135                 140                 


Gln Arg Met Gly Gln Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu 
145                 150                 155                 160 


Ala Lys Tyr Ala Asp Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val 
                165                 170                 175     


Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn 
            180                 185                 190         


Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile 
        195                 200                 205             


Ile Val Asp Asn Ser Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala 
    210                 215                 220                 


Val Pro Val Gln Ser Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu 
225                 230                 235                 240 


Asp Leu Ile Pro Phe Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr 
                245                 250                 255     


Ser Met Leu His Arg Leu Cys Asn Arg 
            260                 265 


<210>  28
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  29
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Thr Leu Glu Arg His Thr Lys Lys Thr Gly Phe Glu Lys Thr 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Thr Pro Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Leu Asn Tyr Lys Phe Pro Ala Thr Val His Met 
65                  70                  75                  80  


Ala His Gln Lys Pro Thr Pro Ala Leu Glu Lys Val Val Pro Leu Lys 
                85                  90                  95      


Arg Ile Tyr Ile Ile Gln Gln Pro Arg Lys Cys 
            100                 105         


<210>  30
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Gly Leu Gly His Pro Ala Ala Phe Gly Arg Ala Thr His Ala 
1               5                   10                  15      


Val Val Arg Ala Leu Pro Glu Ser Leu Gly Gln His Ala Leu Arg Ser 
            20                  25                  30          


Ala Lys Gly Glu Glu Val Asp Val Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Glu 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Ala Asp Gly Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Ile Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Asn Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met 
                245                 250                 255     


Leu Ile Pro Val Ser Met Ser Glu Leu Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Cys Ser Val Leu Ile Asn Lys Lys Val Asp Ser 
        275                 280                 285 


<210>  31
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Val Leu Tyr Leu Leu Phe Ser Phe Leu Phe Ile Phe Leu Met 
1               5                   10                  15      


Pro Leu Pro Gly Val Phe Gly Gly Ile Gly Asp Pro Val Thr Cys Leu 
            20                  25                  30          


Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys Pro Arg Arg Tyr Lys 
        35                  40                  45              


Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys Cys Cys Lys Lys Pro 
    50                  55                  60                  


<210>  32
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe 
65                  70                  75                  80  


Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met 
                85                  90                  95      


Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln 
            100                 105                 110         


Asp Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr 
        115                 120                 125             


Asp Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg 
    130                 135                 140                 


Leu His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro 
145                 150                 155                 160 


Arg Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr 
                165                 170                 175     


His Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys 
            180                 185                 190         


Val Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val 
        195                 200                 205             


Lys Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile 
    210                 215                 220                 


Leu His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val 
225                 230                 235                 240 


Ile Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser 
                245                 250                 255     


Gly Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn 
            260                 265                 270         


Leu Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg 
        275                 280                 285             


Val Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val 
    290                 295                 300                 


Ala Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val 
305                 310                 315                 320 


Ala Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val 
                325                 330                 335     


Phe His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His 
            340                 345                 350         


Pro Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp 
        355                 360                 365             


Asp Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser 
    370                 375                 380                 


Ala Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr 
385                 390                 395                 400 


Gln Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys 
                405                 410                 415     


Ser Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu 
            420                 425                 430         


Val Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro 
        435                 440                 445             


Thr Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val 
    450                 455                 460                 


Tyr Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe 
465                 470                 475                 480 


Glu Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val 
                485                 490                 495     


Gly Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp 
            500                 505                 510         


Thr Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe 
        515                 520                 525             


Glu Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His 
    530                 535                 540                 


Pro Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp 
545                 550                 555                 560 


Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu 
                565                 570                 575     


Gly Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu 
            580                 585                 590         


Val Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly 
        595                 600                 605             


Glu Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr 
    610                 615                 620                 


Leu Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr 
625                 630                 635                 640 


Val Glu Leu Ser Ala 
                645 


<210>  33
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp 
            100                 105                 110         


Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg Leu 
        115                 120                 125             


His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg 
    130                 135                 140                 


Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His 
145                 150                 155                 160 


Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val 
                165                 170                 175     


Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys 
            180                 185                 190         


Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu 
        195                 200                 205             


His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile 
    210                 215                 220                 


Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly 
225                 230                 235                 240 


Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu 
                245                 250                 255     


Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val 
            260                 265                 270         


Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala 
        275                 280                 285             


Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala 
    290                 295                 300                 


Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe 
305                 310                 315                 320 


His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro 
                325                 330                 335     


Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp 
            340                 345                 350         


Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala 
        355                 360                 365             


Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln 
    370                 375                 380                 


Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser 
385                 390                 395                 400 


Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val 
                405                 410                 415     


Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr 
            420                 425                 430         


Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr 
        435                 440                 445             


Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu 
    450                 455                 460                 


Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly 
465                 470                 475                 480 


Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr 
                485                 490                 495     


Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu 
            500                 505                 510         


Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro 
        515                 520                 525             


Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn 
    530                 535                 540                 


Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly 
545                 550                 555                 560 


Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val 
                565                 570                 575     


Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu 
            580                 585                 590         


Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu 
        595                 600                 605             


Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val 
    610                 615                 620                 


Glu Leu Ser Ala 
625             


<210>  34
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly 
            100                 105                 110         


Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser 
        115                 120                 125             


Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro 
                165                 170                 175     


Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu 
            180                 185                 190         


Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu 
        195                 200                 205             


Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu 
    210                 215                 220                 


Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg 
225                 230                 235                 240 


Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met 
                245                 250                 255     


Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn 
            260                 265                 270         


Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn 
        275                 280                 285             


Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser 
    290                 295                 300                 


Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val 
305                 310                 315                 320 


Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His 
                325                 330                 335     


Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr 
            340                 345                 350         


His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn 
        355                 360                 365             


Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser 
385                 390                 395                 400 


Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn 
                405                 410                 415     


Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg 
            420                 425                 430         


His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly 
        435                 440                 445             


Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe 
    450                 455                 460                 


Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp 
465                 470                 475                 480 


Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp 
                485                 490                 495     


Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala 
            500                 505                 510         


Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp 
        515                 520                 525             


Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu 
    530                 535                 540                 


Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp 
545                 550                 555                 560 


Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Leu Ala Val Pro 
                565                 570                 575     


His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val Glu Ile Arg 
            580                 585                 590         


Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val Glu Leu Ser Ala 
        595                 600                 605             


<210>  35
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe 
65                  70                  75                  80  


Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met 
                85                  90                  95      


Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln 
            100                 105                 110         


Asp Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu 
        115                 120                 125             


Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val 
    130                 135                 140                 


Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu 
145                 150                 155                 160 


Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp 
                165                 170                 175     


Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro 
            180                 185                 190         


Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu 
        195                 200                 205             


Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala 
    210                 215                 220                 


Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu 
225                 230                 235                 240 


Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn 
                245                 250                 255     


Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys 
            260                 265                 270         


Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn 
        275                 280                 285             


Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp 
    290                 295                 300                 


Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln 
305                 310                 315                 320 


Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val 
                325                 330                 335     


Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser 
            340                 345                 350         


His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His 
        355                 360                 365             


Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His 
    370                 375                 380                 


Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu 
385                 390                 395                 400 


Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys 
                405                 410                 415     


Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val 
            420                 425                 430         


Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys 
        435                 440                 445             


Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln 
    450                 455                 460                 


Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp 
465                 470                 475                 480 


Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu 
                485                 490                 495     


Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala 
            500                 505                 510         


Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe 
        515                 520                 525             


Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn 
    530                 535                 540                 


Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala 
545                 550                 555                 560 


Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly 
                565                 570                 575     


Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Leu Ala Val 
            580                 585                 590         


Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val Glu Ile 
        595                 600                 605             


Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val Glu Leu Ser 
    610                 615                 620                 


Ala 
625 


<210>  36
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly 
            100                 105                 110         


Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser 
        115                 120                 125             


Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro 
                165                 170                 175     


Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu 
            180                 185                 190         


Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu 
        195                 200                 205             


Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu 
    210                 215                 220                 


Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg 
225                 230                 235                 240 


Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met 
                245                 250                 255     


Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn 
            260                 265                 270         


Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn 
        275                 280                 285             


Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser 
    290                 295                 300                 


Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val 
305                 310                 315                 320 


Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His 
                325                 330                 335     


Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr 
            340                 345                 350         


His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn 
        355                 360                 365             


Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser 
385                 390                 395                 400 


Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn 
                405                 410                 415     


Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg 
            420                 425                 430         


His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly 
        435                 440                 445             


Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe 
    450                 455                 460                 


Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp 
465                 470                 475                 480 


Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp 
                485                 490                 495     


Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala 
            500                 505                 510         


Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp 
        515                 520                 525             


Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu 
    530                 535                 540                 


Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp 
545                 550                 555                 560 


Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Gly Leu Ala Met 
                565                 570                 575     


Leu Pro Gly Trp Ser Gln Asn Ser Trp Thr Gln Ala Ile Leu Leu Cys 
            580                 585                 590         


Trp Pro Pro Lys Val Leu Gly Leu Gln Thr 
        595                 600         


<210>  37
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  38
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Thr Leu Arg Ala Ala Val Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ala Val Phe Gly Val Leu Gly Arg Thr Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Gly Leu Leu Asn Asp Ala Phe Gln Lys Gly Gly Pro Glu Gly 
        35                  40                  45              


Ala Thr Thr Arg Leu Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile 
    50                  55                  60                  


Pro Leu Met Glu Glu Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val 
65                  70                  75                  80  


Cys Leu Pro Lys Asn Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile 
                85                  90                  95      


Ser Ala Arg Lys Ile Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu 
            100                 105                 110         


Arg Lys Lys Gly Phe Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp 
        115                 120                 125             


Asp Arg Ala Glu Arg Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys 
    130                 135                 140                 


Met His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser 
                165                 170                 175     


Pro Ser Glu Val Val Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr 
        195                 200                 205             


Ala Leu Lys Glu Leu Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr 
    210                 215                 220                 


Pro Ala Pro Leu Pro Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly 
225                 230                 235                 240 


Tyr Val Thr Val Lys Pro Arg Val Arg Leu His Phe Val Glu Leu Gly 
                245                 250                 255     


Ser Gly Pro Ala Val Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr 
            260                 265                 270         


Ser Trp Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val 
        275                 280                 285             


Leu Ala Met Asp Met Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu 
    290                 295                 300                 


Ile Glu Glu Tyr Cys Met Glu Val Leu Cys Lys Glu Met Val Thr Phe 
305                 310                 315                 320 


Leu Asp Lys Leu Gly Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp 
                325                 330                 335     


Gly Gly Met Leu Val Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val 
            340                 345                 350         


Arg Ala Val Ala Ser Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn 
        355                 360                 365             


Met Ser Pro Leu Glu Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln 
    370                 375                 380                 


Leu Tyr Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn 
385                 390                 395                 400 


Leu Ser Arg Thr Phe Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val 
                405                 410                 415     


Leu Ser Met His Lys Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser 
            420                 425                 430         


Pro Glu Glu Pro Ser Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln 
        435                 440                 445             


Phe Tyr Val Gln Gln Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn 
    450                 455                 460                 


Trp Tyr Arg Asn Met Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu 
465                 470                 475                 480 


Gly Arg Lys Ile Leu Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp 
                485                 490                 495     


Phe Val Leu Val Pro Gln Met Ser Gln His Met Glu Asp Trp Ile Pro 
            500                 505                 510         


His Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Met 
        515                 520                 525             


Asp Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser 
    530                 535                 540                 


Asp Ala Arg Asn Pro Pro Val Val Ser Lys Met 
545                 550                 555 


<210>  39
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Cys Lys Lys Gln Arg Ser Arg Lys His Ser Val Asn Glu Lys 
1               5                   10                  15      


Cys Asn Met Lys Ile Glu His Tyr Phe Ser Pro Val Ser Lys Glu Gln 
            20                  25                  30          


Gln Asn Asn Cys Ser Thr Ser Leu Met Arg Met Glu Ser Arg Gly Asp 
        35                  40                  45              


Pro Arg Ala Thr Thr Asn Thr Gln Ala Gln Arg Phe His Ser Pro Lys 
    50                  55                  60                  


Lys Asn Pro Glu Asp Gln Thr Met Pro Gln Asn Arg Thr Ile Tyr Val 
65                  70                  75                  80  


Thr Leu Lys Val Asn His Arg Arg Asn Gln Asp Met Lys Leu Lys Leu 
                85                  90                  95      


Thr His Ser Glu Asn Ser Ser Leu Tyr Met Ala Leu Asn Thr Leu Gln 
            100                 105                 110         


Ala Val Arg Lys Glu Ile Glu Thr His Gln Gly Gln Glu Met Leu Val 
        115                 120                 125             


Arg Gly Thr Glu Gly Ile Lys Glu Tyr Ile Asn Leu Gly Met Pro Leu 
    130                 135                 140                 


Ser Cys Phe Pro Glu Gly Gly Gln Val Val Ile Thr Phe Ser Gln Ser 
145                 150                 155                 160 


Lys Ser Lys Gln Lys Glu Asp Asn His Ile Phe Gly Arg Gln Asp Lys 
                165                 170                 175     


Ala Ser Thr Glu Cys Val Lys Phe Tyr Ile His Ala Ile Gly Ile Gly 
            180                 185                 190         


Lys Cys Lys Arg Arg Ile Val Lys Cys Gly Lys Leu His Lys Lys Gly 
        195                 200                 205             


Arg Lys Leu Cys Val Tyr Ala Phe Lys Gly Glu Thr Ile Lys Asp Ala 
    210                 215                 220                 


Leu Cys Lys Asp Gly Arg Phe Leu Ser Phe Leu Glu Asn Asp Asp Trp 
225                 230                 235                 240 


Lys Leu Ile Glu Asn Asn Asp Thr Ile Leu Glu Ser Thr Gln Pro Val 
                245                 250                 255     


Asp Glu Leu Glu Gly Arg Tyr Phe Gln Val Glu Val Glu Lys Arg Met 
            260                 265                 270         


Val Pro Ser Ala Ala Ala Ser Gln Asn Pro Glu Ser Glu Lys Arg Asn 
        275                 280                 285             


Thr Cys Val Leu Arg Glu Gln Ile Val Ala Gln Tyr Pro Ser Leu Lys 
    290                 295                 300                 


Arg Glu Ser Glu Lys Ile Ile Glu Asn Phe Lys Lys Lys Met Lys Val 
305                 310                 315                 320 


Lys Asn Gly Glu Thr Leu Phe Glu Leu His Arg Thr Thr Phe Gly Lys 
                325                 330                 335     


Val Thr Lys Asn Ser Ser Ser Ile Lys Val Val Lys Leu Leu Val Arg 
            340                 345                 350         


Leu Ser Asp Ser Val Gly Tyr Leu Phe Trp Asp Ser Ala Thr Thr Gly 
        355                 360                 365             


Tyr Ala Thr Cys Phe Val Phe Lys Gly Leu Phe Ile Leu Thr Cys Arg 
    370                 375                 380                 


His Val Ile Asp Ser Ile Val Gly Asp Gly Ile Glu Pro Ser Lys Trp 
385                 390                 395                 400 


Ala Thr Ile Ile Gly Gln Cys Val Arg Val Thr Phe Gly Tyr Glu Glu 
                405                 410                 415     


Leu Lys Asp Lys Glu Thr Asn Tyr Phe Phe Val Glu Pro Trp Phe Glu 
            420                 425                 430         


Ile His Asn Glu Glu Leu Asp Tyr Ala Val Leu Lys Leu Lys Glu Asn 
        435                 440                 445             


Gly Gln Gln Val Pro Met Glu Leu Tyr Asn Gly Ile Thr Pro Val Pro 
    450                 455                 460                 


Leu Ser Gly Leu Ile His Ile Ile Gly His Pro Tyr Gly Glu Lys Lys 
465                 470                 475                 480 


Gln Ile Asp Ala Cys Ala Val Ile Pro Gln Gly Gln Arg Ala Lys Lys 
                485                 490                 495     


Cys Gln Glu Arg Val Gln Ser Lys Lys Ala Glu Ser Pro Glu Tyr Val 
            500                 505                 510         


His Met Tyr Thr Gln Arg Ser Phe Gln Lys Ile Val His Asn Pro Asp 
        515                 520                 525             


Val Ile Thr Tyr Asp Thr Glu Phe Phe Phe Gly Ala Ser Gly Ser Pro 
    530                 535                 540                 


Val Phe Asp Ser Lys Gly Ser Leu Val Ala Met His Ala Ala Gly Phe 
545                 550                 555                 560 


Ala Tyr Thr Tyr Gln Asn Glu Thr Arg Ser Ile Ile Glu Phe Gly Ser 
                565                 570                 575     


Thr Met Glu Ser Ile Leu Leu Asp Ile Lys Gln Arg His Lys Pro Trp 
            580                 585                 590         


Tyr Glu Glu Val Phe Val Asn Gln Gln Asp Val Glu Met Met Ser Asp 
        595                 600                 605             


Glu Asp Leu 
    610     


<210>  40
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Pro Leu Ala Gly Gly Leu Leu Lys Val Val Phe Val Val Phe 
1               5                   10                  15      


Ala Ser Leu Cys Ala Trp Tyr Ser Gly Tyr Leu Leu Ala Glu Leu Ile 
            20                  25                  30          


Pro Asp Ala Pro Leu Ser Ser Ala Ala Tyr Ser Ile Arg Ser Ile Gly 
        35                  40                  45              


Glu Arg Pro Val Leu Lys Ala Pro Val Pro Lys Arg Gln Lys Cys Asp 
    50                  55                  60                  


His Trp Thr Pro Cys Pro Ser Asp Thr Tyr Ala Tyr Arg Leu Leu Ser 
65                  70                  75                  80  


Gly Gly Gly Arg Ser Lys Tyr Ala Lys Ile Cys Phe Glu Asp Asn Leu 
                85                  90                  95      


Leu Met Gly Glu Gln Leu Gly Asn Val Ala Arg Gly Ile Asn Ile Ala 
            100                 105                 110         


Ile Val Asn Tyr Val Thr Gly Asn Val Thr Ala Thr Arg Cys Phe Asp 
        115                 120                 125             


Met Tyr Glu Gly Asp Asn Ser Gly Pro Met Thr Lys Phe Ile Gln Ser 
    130                 135                 140                 


Ala Ala Pro Lys Ser Leu Leu Phe Met Val Thr Tyr Asp Asp Gly Ser 
145                 150                 155                 160 


Thr Arg Leu Asn Asn Asp Ala Lys Asn Ala Ile Glu Ala Leu Gly Ser 
                165                 170                 175     


Lys Glu Ile Arg Asn Met Lys Phe Arg Ser Ser Trp Val Phe Ile Ala 
            180                 185                 190         


Ala Lys Gly Leu Glu Leu Pro Ser Glu Ile Gln Arg Glu Lys Ile Asn 
        195                 200                 205             


His Ser Asp Ala Lys Asn Asn Arg Tyr Ser Gly Trp Pro Ala Glu Ile 
    210                 215                 220                 


Gln Ile Glu Gly Cys Ile Pro Lys Glu Arg Ser 
225                 230                 235 


<210>  41
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser Arg Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Glu Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210>  42
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Ser Gly Pro Lys Met Leu Ala Pro Val Cys Leu Val Glu Asn 
1               5                   10                  15      


Asn Asn Glu Gln Leu Leu Val Asn Gln Gln Ala Ile Gln Ile Leu Glu 
            20                  25                  30          


Lys Ile Ser Gln Pro Val Val Val Val Ala Ile Val Gly Leu Tyr Arg 
        35                  40                  45              


Thr Gly Lys Ser Tyr Leu Met Asn His Leu Ala Gly Gln Asn His Gly 
    50                  55                  60                  


Phe Pro Leu Gly Ser Thr Val Gln Ser Glu Thr Lys Gly Ile Trp Met 
65                  70                  75                  80  


Trp Cys Val Pro His Pro Ser Lys Pro Asn His Thr Leu Val Leu Leu 
                85                  90                  95      


Asp Thr Glu Gly Leu Gly Asp Val Glu Lys Gly Asp Pro Lys Asn Asp 
            100                 105                 110         


Ser Trp Ile Phe Ala Leu Ala Val Leu Leu Cys Ser Thr Phe Val Tyr 
        115                 120                 125             


Asn Ser Met Ser Thr Ile Asn His Gln Ala Leu Glu Gln Leu His Tyr 
    130                 135                 140                 


Val Thr Glu Leu Thr Glu Leu Ile Lys Ala Lys Ser Ser Pro Arg Pro 
145                 150                 155                 160 


Asp Gly Val Glu Asp Ser Thr Glu Phe Val Ser Phe Phe Pro Asp Phe 
                165                 170                 175     


Leu Trp Thr Val Arg Asp Phe Thr Leu Glu Leu Lys Leu Asn Gly His 
            180                 185                 190         


Pro Ile Thr Glu Asp Glu Tyr Leu Glu Asn Ala Leu Lys Leu Ile Gln 
        195                 200                 205             


Gly Asn Asn Pro Arg Val Gln Thr Ser Asn Phe Pro Arg Glu Cys Ile 
    210                 215                 220                 


Arg Arg Phe Phe Pro Lys Arg Lys Cys Phe Val Phe Asp Arg Pro Thr 
225                 230                 235                 240 


Asn Asp Lys Asp Leu Leu Ala Asn Ile Glu Lys Val Ser Glu Lys Gln 
                245                 250                 255     


Leu Asp Pro Lys Phe Gln Glu Gln Thr Asn Ile Phe Cys Ser Tyr Ile 
            260                 265                 270         


Phe Thr His Ala Arg Thr Lys Thr Leu Arg Glu Gly Ile Thr Val Thr 
        275                 280                 285             


Gly Asn Arg Leu Gly Thr Leu Ala Val Thr Tyr Val Glu Ala Ile Asn 
    290                 295                 300                 


Ser Gly Ala Val Pro Cys Leu Glu Asn Ala Val Ile Thr Leu Ala Gln 
305                 310                 315                 320 


Arg Glu Asn Ser Ala Ala Val Gln Arg Ala Ala Asp Tyr Tyr Ser Gln 
                325                 330                 335     


Gln Met Ala Gln Arg Val Lys Leu Pro Thr Asp Thr Leu Gln Glu Leu 
            340                 345                 350         


Leu Asp Met His Ala Ala Cys Glu Arg Glu Ala Ile Ala Ile Phe Met 
        355                 360                 365             


Glu His Ser Phe Lys Asp Glu Asn Gln Glu Phe Gln Lys Lys Phe Met 
    370                 375                 380                 


Glu Thr Thr Met Asn Lys Lys Gly Asp Phe Leu Leu Gln Asn Glu Glu 
385                 390                 395                 400 


Ser Ser Val Gln Tyr Cys Gln Ala Lys Leu Asn Glu Leu Ser Lys Gly 
                405                 410                 415     


Leu Met Glu Ser Ile Ser Ala Gly Ser Phe Ser Val Pro Gly Gly His 
            420                 425                 430         


Lys Leu Tyr Met Glu Thr Lys Glu Arg Ile Glu Gln Asp Tyr Trp Gln 
        435                 440                 445             


Val Pro Arg Lys Gly Val Lys Ala Lys Glu Val Phe Gln Arg Phe Leu 
    450                 455                 460                 


Glu Ser Gln Met Val Ile Glu Glu Ser Ile Leu Gln Ser Asp Lys Ala 
465                 470                 475                 480 


Leu Thr Asp Arg Glu Lys Ala Val Ala Val Asp Arg Ala Lys Lys Glu 
                485                 490                 495     


Ala Ala Glu Lys Glu Gln Glu Leu Leu Lys Gln Lys Leu Gln Glu Gln 
            500                 505                 510         


Gln Gln Gln Met Glu Ala Gln Asp Lys Ser Arg Lys Glu Asn Ile Ala 
        515                 520                 525             


Gln Leu Lys Glu Lys Leu Gln Met Glu Arg Glu His Leu Leu Arg Glu 
    530                 535                 540                 


Gln Ile Met Met Leu Glu His Thr Gln Lys Val Gln Asn Asp Trp Leu 
545                 550                 555                 560 


His Glu Gly Phe Lys Lys Lys Tyr Glu Glu Met Asn Ala Glu Ile Ser 
                565                 570                 575     


Gln Phe Lys Arg Met Ile Asp Thr Thr Lys Asn Asp Asp Thr Pro Trp 
            580                 585                 590         


Ile Ala Arg Thr Leu Asp Asn Leu Ala Asp Glu Leu Thr Ala Ile Leu 
        595                 600                 605             


Ser Ala Pro Ala Lys Leu Ile Gly His Gly Val Lys Gly Val Ser Ser 
    610                 615                 620                 


Leu Phe Lys Lys His Lys Leu Pro Phe 
625                 630             


<210>  43
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln 
    450                 455                 460                 


Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala 
465                 470                 475                 480 


Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys 
                485                 490                 495     


Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val 
            500                 505                 510         


Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu 
        515                 520                 525             


Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val 
    530                 535                 540                 


Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser 
545                 550                 555                 560 


Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                565                 


<210>  44
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Ile Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  45
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ala Arg Pro Lys Leu His Tyr Pro Asn Gly Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Val Arg Trp Val Leu Ala Ala Ala Gly Val Glu Phe Asp Glu 
            20                  25                  30          


Glu Phe Leu Glu Thr Lys Glu Gln Leu Tyr Lys Leu Gln Asp Gly Asn 
        35                  40                  45              


His Leu Leu Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ser Ile Leu His Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Leu Phe Gly Lys Asn Leu Lys Glu Arg Thr Leu Ile Asp Met Tyr Val 
                85                  90                  95      


Glu Gly Thr Leu Asp Leu Leu Glu Leu Leu Ile Met His Pro Phe Leu 
            100                 105                 110         


Lys Pro Asp Asp Gln Gln Lys Glu Val Val Asn Met Ala Gln Lys Ala 
        115                 120                 125             


Ile Ile Arg Tyr Phe Pro Val Phe Glu Lys Ile Leu Arg Gly His Gly 
    130                 135                 140                 


Gln Ser Phe Leu Val Gly Asn Gln Leu Ser Leu Ala Asp Val Ile Leu 
145                 150                 155                 160 


Leu Gln Thr Ile Leu Ala Leu Glu Glu Lys Ile Pro Asn Ile Leu Ser 
                165                 170                 175     


Ala Phe Pro Phe Leu Gln Glu Tyr Thr Val Lys Leu Ser Asn Ile Pro 
            180                 185                 190         


Thr Ile Lys Arg Phe Leu Glu Pro Gly Ser Lys Lys Lys Pro Pro Pro 
        195                 200                 205             


Asp Glu Ile Tyr Val Arg Thr Val Tyr Asn Ile Phe Arg Pro 
    210                 215                 220         


<210>  46
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  47
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Thr Thr Ser Ile Arg Gln Phe Thr Ser Ser Ser Ser Ile Lys Gly 
1               5                   10                  15      


Ser Ser Gly Leu Gly Gly Gly Ser Ser Arg Thr Ser Cys Arg Leu Ser 
            20                  25                  30          


Gly Gly Leu Gly Ala Gly Ser Cys Arg Leu Gly Ser Ala Gly Gly Leu 
        35                  40                  45              


Gly Ser Thr Leu Gly Gly Ser Ser Tyr Ser Ser Cys Tyr Ser Phe Gly 
    50                  55                  60                  


Ser Gly Gly Gly Tyr Gly Ser Ser Phe Gly Gly Val Asp Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Gly Glu Lys Ala Thr Met Gln Asn Leu Asn Asp Arg Leu Ala 
                85                  90                  95      


Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Thr Glu Leu 
            100                 105                 110         


Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Ala Pro Gly Pro Ala 
        115                 120                 125             


Arg Asp Tyr Ser Gln Tyr Tyr Arg Thr Ile Glu Glu Leu Gln Asn Lys 
    130                 135                 140                 


Ile Leu Thr Ala Thr Val Asp Asn Ala Asn Ile Leu Leu Gln Ile Asp 
145                 150                 155                 160 


Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu 
                165                 170                 175     


Gln Ala Leu Arg Leu Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg 
            180                 185                 190         


Val Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile 
        195                 200                 205             


Glu Asn Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu 
    210                 215                 220                 


Glu Met Asn Ala Leu Arg Gly Gln Val Gly Gly Glu Ile Asn Val Glu 
225                 230                 235                 240 


Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met 
                245                 250                 255     


Arg Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu 
            260                 265                 270         


Asp Trp Phe Phe Ser Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr 
        275                 280                 285             


Asn Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg 
    290                 295                 300                 


Arg Thr Met Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met 
305                 310                 315                 320 


Lys Ala Ser Leu Glu Gly Asn Leu Ala Glu Thr Glu Asn Arg Tyr Cys 
                325                 330                 335     


Val Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu Gln 
            340                 345                 350         


Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys 
        355                 360                 365             


Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr 
    370                 375                 380                 


Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr Lys Lys 
385                 390                 395                 400 


Glu Pro Val Thr Thr Arg Gln Val Arg Thr Ile Val Glu Glu Val Gln 
                405                 410                 415     


Asp Gly Lys Val Ile Ser Ser Arg Glu Gln Val His Gln Thr Thr Arg 
            420                 425                 430         


<210>  48
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 
1               5                   10                  15      


Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 
            20                  25                  30          


Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 
        35                  40                  45              


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 
    50                  55                  60                  


Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 
65                  70                  75                  80  


Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
        115                 120                 125             


Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 
    130                 135                 140                 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 
                165                 170                 175     


Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 
            180                 185                 190         


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 
        195                 200                 205             


Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
    210                 215                 220                 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
225                 230                 235                 240 


Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 
                245                 250                 255     


Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 
            260                 265                 270         


Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 
    290                 295                 300                 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 
305                 310                 315                 320 


Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 
                325                 330                 335     


Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 
            340                 345                 350         


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 
        355                 360                 365             


Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
385                 390                 395                 400 


Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 
                405                 410                 415     


Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 
            420                 425                 430         


Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly 
        435                 440                 445             


Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys 
    450                 455                 460                 


Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val 
465                 470                 475                 480 


Leu Pro Lys 
            


<210>  49
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Glu Gly Glu Ser Met Thr Phe Asp 
            260                 265                 270         


Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg Ser 
        275                 280                 285             


Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr Pro 
    290                 295                 300                 


Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile Met 
305                 310                 315                 320 


Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330             


<210>  50
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Ser 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile His Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  51
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Asp Arg Pro Ala Ala Ala Ala Ala Ala Gly Cys Glu Gly Gly Gly 
1               5                   10                  15      


Gly Pro Asn Pro Gly Pro Ala Gly Gly Arg Arg Pro Pro Arg Ala Ala 
            20                  25                  30          


Gly Gly Ala Thr Ala Gly Ser Arg Gln Pro Ser Val Glu Thr Leu Asp 
        35                  40                  45              


Ser Pro Thr Gly Ser His Val Glu Trp Cys Lys Gln Leu Ile Ala Ala 
    50                  55                  60                  


Thr Ile Ser Ser Gln Ile Ser Gly Ser Val Thr Ser Glu Asn Val Ser 
65                  70                  75                  80  


Arg Asp Tyr Lys Ala Leu Arg Asp Gly Asn Lys Leu Ala Gln Met Glu 
                85                  90                  95      


Glu Ala Pro Leu Phe Pro Gly Glu Ser Ile Lys Ala Ile Val Lys Asp 
            100                 105                 110         


Val Met Tyr Ile Cys Pro Phe Met Gly Ala Val Ser Gly Thr Leu Thr 
        115                 120                 125             


Val Thr Asp Phe Lys Leu Tyr Phe Lys Asn Val Glu Arg Asp Pro His 
    130                 135                 140                 


Phe Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Val Glu Lys Ile 
145                 150                 155                 160 


Gly Ala Gln Ser His Gly Asp Asn Ser Cys Gly Ile Glu Ile Val Cys 
                165                 170                 175     


Lys Asp Met Arg Asn Leu Arg Leu Ala Tyr Lys Gln Glu Glu Gln Ser 
            180                 185                 190         


Lys Leu Gly Ile Phe Glu Asn Leu Asn Lys His Ala Phe Pro Leu Ser 
        195                 200                 205             


Asn Gly Gln Ala Leu Phe Ala Phe Ser Tyr Lys Glu Lys Phe Pro Ile 
    210                 215                 220                 


Asn Gly Trp Lys Val Tyr Asp Pro Val Ser Glu Tyr Lys Arg Gln Gly 
225                 230                 235                 240 


Leu Pro Asn Glu Ser Trp Lys Ile Ser Lys Ile Asn Ser Asn Tyr Glu 
                245                 250                 255     


Phe Cys Asp Thr Tyr Pro Ala Ile Ile Val Val Pro Thr Ser Val Lys 
            260                 265                 270         


Asp Asp Asp Leu Ser Lys Val Ala Ala Phe Arg Ala Lys Gly Arg Val 
        275                 280                 285             


Pro Val Leu Ser Trp Ile His Pro Glu Ser Gln Ala Thr Ile Thr Arg 
    290                 295                 300                 


Cys Ser Gln Pro Leu Val Gly Pro Asn Asp Lys Arg Cys Lys Glu Asp 
305                 310                 315                 320 


Glu Lys Tyr Leu Gln Thr Ile Met Asp Ala Asn Ala Gln Ser His Lys 
                325                 330                 335     


Leu Ile Ile Phe Asp Ala Arg Gln Asn Ser Val Ala Asp Thr Asn Lys 
            340                 345                 350         


Thr Lys Gly Gly Gly Tyr Glu Ser Glu Ser Ala Tyr Pro Asn Ala Glu 
        355                 360                 365             


Leu Val Phe Leu Glu Ile His Asn Ile His Val Met Arg Glu Ser Leu 
    370                 375                 380                 


Arg Lys Leu Lys Glu Ile Val Tyr Pro Ser Ile Asp Glu Ala Arg Trp 
385                 390                 395                 400 


Leu Ser Asn Val Asp Gly Thr His Trp Leu Glu Tyr Ile Arg Met Leu 
                405                 410                 415     


Leu Ala Gly Ala Val Arg Ile Ala Asp Lys Ile Glu Ser Gly Lys Thr 
            420                 425                 430         


Ser Val Val Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln Leu 
        435                 440                 445             


Thr Ser Leu Ala Met Leu Met Leu Asp Ser Tyr Tyr Arg Thr Ile Lys 
    450                 455                 460                 


Gly Phe Glu Thr Leu Val Glu Lys Glu Trp Ile Ser Phe Gly His Arg 
465                 470                 475                 480 


Phe Ala Leu Arg Val Gly His Gly Asn Asp Asn His Ala Asp Ala Asp 
                485                 490                 495     


Arg Ser Pro Ile Phe Leu Gln Phe Val Asp Cys Val Trp Gln Met Thr 
            500                 505                 510         


Arg Gln Phe Pro Ser Ala Phe Glu Phe Asn Glu Leu Phe Leu Ile Thr 
        515                 520                 525             


Ile Leu Asp His Leu Tyr Ser Cys Leu Phe Gly Thr Phe Leu Cys Asn 
    530                 535                 540                 


Cys Glu Gln Gln Arg Phe Lys Glu Asp Val Tyr Thr Lys Thr Ile Ser 
545                 550                 555                 560 


Leu Trp Ser Tyr Ile Asn Ser Gln Leu Asp Glu Phe Ser Asn Pro Phe 
                565                 570                 575     


Phe Val Asn Tyr Glu Asn His Val Leu Tyr Pro Val Ala Ser Leu Ser 
            580                 585                 590         


His Leu Glu Leu Trp Val Asn Tyr Tyr Val Arg Trp Asn Pro Arg Met 
        595                 600                 605             


Arg Pro Gln Met Pro Ile His Gln Asn Leu Lys Glu Leu Leu Ala Val 
    610                 615                 620                 


Arg Ala Glu Leu Gln Lys Arg Val Glu Gly Leu Gln Arg Glu Val Ala 
625                 630                 635                 640 


Thr Arg Ala Val Ser Ser Ser Ser Glu Arg Gly Ser Ser Pro Ser His 
                645                 650                 655     


Ser Ala Thr Ser Val His Thr Ser Val 
            660                 665 


<210>  52
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Trp Lys Val Ser Ala Leu Leu Phe Val Leu Gly Ser Ala Ser Leu 
1               5                   10                  15      


Trp Val Leu Ala Glu Gly Ala Ser Thr Gly Gln Pro Glu Asp Asp Thr 
            20                  25                  30          


Glu Thr Thr Gly Leu Glu Gly Gly Val Ala Met Pro Gly Ala Glu Asp 
        35                  40                  45              


Asp Val Val Thr Pro Gly Thr Ser Glu Asp Arg Tyr Lys Ser Gly Leu 
    50                  55                  60                  


Thr Thr Leu Val Ala Thr Ser Val Asn Ser Val Thr Gly Ile Arg Ile 
65                  70                  75                  80  


Glu Asp Leu Pro Thr Ser Glu Ser Thr Val His Ala Gln Glu Gln Ser 
                85                  90                  95      


Pro Ser Ala Thr Ala Ser Asn Val Ala Thr Ser His Ser Thr Glu Lys 
            100                 105                 110         


Val Asp Gly Asp Thr Gln Thr Thr Val Glu Lys Asp Gly Leu Ser Thr 
        115                 120                 125             


Val Thr Leu Val Gly Ile Ile Val Gly Val Leu Leu Ala Ile Gly Phe 
    130                 135                 140                 


Ile Gly Gly Ile Ile Val Val Val Met Arg Lys Met Ser Gly Arg Tyr 
145                 150                 155                 160 


Ser Pro 
        


<210>  53
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  54
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Gln Asn Leu Lys Asp Leu Ala Gly Arg Leu Pro Ala Gly Pro 
1               5                   10                  15      


Arg Gly Met Gly Thr Ala Leu Lys Leu Leu Leu Gly Ala Gly Ala Val 
            20                  25                  30          


Ala Tyr Gly Val Arg Glu Ser Val Phe Thr Val Glu Gly Gly His Arg 
        35                  40                  45              


Ala Ile Phe Phe Asn Arg Ile Gly Gly Val Gln Gln Asp Thr Ile Leu 
    50                  55                  60                  


Ala Glu Gly Leu His Phe Arg Ile Pro Trp Phe Gln Tyr Pro Ile Ile 
65                  70                  75                  80  


Tyr Asp Ile Arg Ala Arg Pro Arg Lys Ile Ser Ser Pro Thr Gly Ser 
                85                  90                  95      


Lys Asp Leu Gln Met Val Asn Ile Ser Leu Arg Val Leu Ser Arg Pro 
            100                 105                 110         


Asn Ala Gln Glu Leu Pro Ser Met Tyr Gln Arg Leu Gly Leu Asp Tyr 
        115                 120                 125             


Glu Glu Arg Val Leu Pro Ser Ile Val Asn Glu Val Leu Lys Ser Val 
    130                 135                 140                 


Val Ala Lys Phe Asn Ala Ser Gln Leu Ile Thr Gln Arg Ala Gln Val 
145                 150                 155                 160 


Ser Leu Leu Ile Arg Arg Glu Leu Thr Glu Arg Ala Lys Asp Phe Ser 
                165                 170                 175     


Leu Ile Leu Asp Asp Val Ala Ile Thr Glu Leu Ser Phe Ser Arg Glu 
            180                 185                 190         


Tyr Thr Ala Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu Ala Gln 
        195                 200                 205             


Arg Ala Gln Phe Leu Val Glu Lys Ala Lys Gln Glu Gln Arg Gln Lys 
    210                 215                 220                 


Ile Val Gln Ala Glu Gly Glu Ala Glu Ala Ala Lys Met Leu Gly Glu 
225                 230                 235                 240 


Ala Leu Ser Lys Asn Pro Gly Tyr Ile Lys Leu Arg Lys Ile Arg Ala 
                245                 250                 255     


Ala Gln Asn Ile Ser Lys Thr Ile Ala Thr Ser Gln Asn Arg Ile Tyr 
            260                 265                 270         


Leu Thr Ala Asp Asn Leu Val Leu Asn Leu Gln Asp Glu Ser Phe Thr 
        275                 280                 285             


Arg Gly Ser Asp Ser Leu Ile Lys Gly Lys Lys 
    290                 295                 


<210>  55
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Phe Ala Asn Leu Arg Lys Val Leu Ile Ser Asp Ser Leu Asp 
1               5                   10                  15      


Pro Cys Cys Arg Lys Ile Leu Gln Asp Gly Gly Leu Gln Val Val Glu 
            20                  25                  30          


Lys Gln Asn Leu Ser Lys Glu Glu Leu Ile Ala Glu Leu Gln Asp Cys 
        35                  40                  45              


Glu Gly Leu Ile Val Arg Ser Ala Thr Lys Val Thr Ala Asp Val Ile 
    50                  55                  60                  


Asn Ala Ala Glu Lys Leu Gln Val Val Gly Arg Ala Gly Thr Gly Val 
65                  70                  75                  80  


Asp Asn Val Asp Leu Glu Ala Ala Thr Arg Lys Gly Ile Leu Val Met 
                85                  90                  95      


Asn Thr Pro Asn Gly Asn Ser Leu Ser Ala Ala Glu Leu Thr Cys Gly 
            100                 105                 110         


Met Ile Met Cys Leu Ala Arg Gln Ile Pro Gln Ala Thr Ala Ser Met 
        115                 120                 125             


Lys Asp Gly Lys Trp Glu Arg Lys Lys Phe Met Gly Thr Glu Leu Asn 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg Glu Val 
145                 150                 155                 160 


Ala Thr Arg Met Gln Ser Phe Gly Met Lys Thr Ile Gly Tyr Asp Pro 
                165                 170                 175     


Ile Ile Ser Pro Glu Val Ser Ala Ser Phe Gly Val Gln Gln Leu Pro 
            180                 185                 190         


Leu Glu Glu Ile Trp Pro Leu Cys Asp Phe Ile Thr Val His Thr Pro 
        195                 200                 205             


Leu Leu Pro Ser Thr Thr Gly Leu Leu Asn Asp Asn Thr Phe Ala Gln 
    210                 215                 220                 


Cys Lys Lys Gly Val Arg Val Val Asn Cys Ala Arg Gly Gly Ile Val 
225                 230                 235                 240 


Asp Glu Gly Ala Leu Leu Arg Ala Leu Gln Ser Gly Gln Cys Ala Gly 
                245                 250                 255     


Ala Ala Leu Asp Val Phe Thr Glu Glu Pro Pro Arg Asp Arg Ala Leu 
            260                 265                 270         


Val Asp His Glu Asn Val Ile Ser Cys Pro His Leu Gly Ala Ser Thr 
        275                 280                 285             


Lys Glu Ala Gln Ser Arg Cys Gly Glu Glu Ile Ala Val Gln Phe Val 
    290                 295                 300                 


Asp Met Val Lys Gly Lys Ser Leu Thr Gly Val Val Asn Ala Gln Ala 
305                 310                 315                 320 


Leu Thr Ser Ala Phe Ser Pro His Thr Lys Pro Trp Ile Gly Leu Ala 
                325                 330                 335     


Glu Ala Leu Gly Thr Leu Met Arg Ala Trp Ala Gly Ser Pro Lys Gly 
            340                 345                 350         


Thr Ile Gln Val Ile Thr Gln Gly Thr Ser Leu Lys Asn Ala Gly Asn 
        355                 360                 365             


Cys Leu Ser Pro Ala Val Ile Val Gly Leu Leu Lys Glu Ala Ser Lys 
    370                 375                 380                 


Gln Ala Asp Val Asn Leu Val Asn Ala Lys Leu Leu Val Lys Glu Ala 
385                 390                 395                 400 


Gly Leu Asn Val Thr Thr Ser His Ser Pro Ala Ala Pro Gly Glu Gln 
                405                 410                 415     


Gly Phe Gly Glu Cys Leu Leu Ala Val Ala Leu Ala Gly Ala Pro Tyr 
            420                 425                 430         


Gln Ala Val Gly Leu Val Gln Gly Thr Thr Pro Val Leu Gln Gly Leu 
        435                 440                 445             


Asn Gly Ala Val Phe Arg Pro Glu Val Pro Leu Arg Arg Asp Leu Pro 
    450                 455                 460                 


Leu Leu Leu Phe Arg Thr Gln Thr Ser Asp Pro Ala Met Leu Pro Thr 
465                 470                 475                 480 


Met Ile Gly Leu Leu Ala Glu Ala Gly Val Arg Leu Leu Ser Tyr Gln 
                485                 490                 495     


Thr Ser Leu Val Ser Asp Gly Glu Thr Trp His Val Met Gly Ile Ser 
            500                 505                 510         


Ser Leu Leu Pro Ser Leu Glu Ala Trp Lys Gln His Val Thr Glu Ala 
        515                 520                 525             


Phe Gln Phe His Phe 
    530             


<210>  56
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp Ser Glu Lys Pro Ser 
            20                  25                  30          


Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr Val Ala Thr Lys Glu 
        35                  40                  45              


Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala Lys Tyr Phe Asn Tyr 
    50                  55                  60                  


Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp Arg Gly Gly Asp Gly 
65                  70                  75                  80  


Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg Leu Met Lys Glu Val 
                85                  90                  95      


Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val Val Met Phe Thr Glu 
            100                 105                 110         


Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu Glu Val Leu Lys Lys 
        115                 120                 125             


Phe Gln Lys Ala Asn His Lys Val Val Phe Ala Ala Asp Gly Ile Leu 
    130                 135                 140                 


Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro Val Val His Ile Gly 
145                 150                 155                 160 


Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly Tyr Ala Pro Tyr Val 
                165                 170                 175     


Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp Asn Asp Asp Asp Gln 
            180                 185                 190         


Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu Lys Arg Glu Ala Ile 
        195                 200                 205             


Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe Gln Thr Leu Asn Gly 
    210                 215                 220                 


Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn Gly Lys Ala Arg Ala 
225                 230                 235                 240 


Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala Ile Asn Gly Asn Gly 
                245                 250                 255     


Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn Tyr Val Pro Asn Ser 
            260                 265                 270         


Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu Phe Asp Thr Val Asp 
        275                 280                 285             


Leu Ser Ala Val Asp Val His Pro Asn Val Ser Ile Gly Val Phe Ile 
    290                 295                 300                 


Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Asp Ile Leu Leu Thr 
305                 310                 315                 320 


Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe Ile His Asn Lys Glu 
                325                 330                 335     


Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe Asp Lys Ala Lys His 
            340                 345                 350         


Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln 
        355                 360                 365             


Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys Arg Gln Asp Glu Lys 
    370                 375                 380                 


Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val Val Leu Thr Asn Pro 
385                 390                 395                 400 


Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg Lys Ile Ile Ala Pro 
                405                 410                 415     


Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 
            420                 425                 430         


Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Asp Ile Val 
        435                 440                 445             


Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro Tyr Met Ala Asn Val 
    450                 455                 460                 


Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu Met Asn Glu Arg Asn 
465                 470                 475                 480 


Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met Ala Leu Cys Arg Asn 
                485                 490                 495     


Ala Arg Glu Met Thr Leu Gln Arg Glu Lys Asp Ser Pro Thr Pro Glu 
            500                 505                 510         


Thr Phe Gln Met Leu Ser Pro Pro Lys Gly Val Phe Met Tyr Ile Ser 
        515                 520                 525             


Asn Arg His Glu Phe Gly Arg Leu Leu Ser Thr Ala Asn Tyr Asn Thr 
    530                 535                 540                 


Ser His Tyr Asn Asn Asp Leu Trp Gln Ile Phe Glu Asn Pro Val Asp 
545                 550                 555                 560 


Trp Lys Glu Lys Tyr Ile Asn Arg Asp Tyr Ser Lys Ile Phe Thr Glu 
                565                 570                 575     


Asn Ile Val Glu Gln Pro Cys Pro Asp Val Phe Trp Phe Pro Ile Phe 
            580                 585                 590         


Ser Glu Lys Ala Cys Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly 
        595                 600                 605             


Lys Trp Ser Gly Gly Lys His His Asp Ser Arg Ile Ser Gly Gly Tyr 
    610                 615                 620                 


Glu Asn Val Pro Thr Asp Asp Ile His Met Lys Gln Val Asp Leu Glu 
625                 630                 635                 640 


Asn Val Trp Leu His Phe Ile Arg Glu Phe Ile Ala Pro Val Thr Leu 
                645                 650                 655     


Lys Val Phe Ala Gly Tyr Tyr Thr Lys Gly Phe Ala Leu Leu Asn Phe 
            660                 665                 670         


Val Val Lys Tyr Ser Pro Glu Arg Gln Arg Ser Leu Arg Pro His His 
        675                 680                 685             


Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu Asn Asn Val Gly Glu 
    690                 695                 700                 


Asp Phe Gln Gly Gly Gly Cys Lys Phe Leu Arg Tyr Asn Cys Ser Ile 
705                 710                 715                 720 


Glu Ser Pro Arg Lys Gly Trp Ser Phe Met His Pro Gly Arg Leu Thr 
                725                 730                 735     


His Leu His Glu Gly Leu Pro Val Lys Asn Gly Thr Arg Tyr Ile Ala 
            740                 745                 750         


Val Ser Phe Ile Asp Pro 
        755             


<210>  57
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  58
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly 
                725                 730                 735     


Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln 
            740                 745                 750         


Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly 
        755                 760                 765             


Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 


<210>  59
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
        755                 760                 765             


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 780     


<210>  60
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys 
                725                 730                 735     


Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 750     


<210>  61
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp 
        755                 760                 765             


Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp 
    770                 775                 780                 


Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg 
785                 790                 795                 800 


Arg Arg Leu Arg Glu Gly Arg Ser Gln 
                805                 


<210>  62
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile 
    690                 695                 700                 


Glu Gly Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu 
705                 710                 715                 720 


Leu Gln Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
                725                 730                 735     


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 


<210>  63
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala 
    690                 695                 700                 


Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser 
705                 710                 715                 720 


Gln 
    


<210>  64
<211>  1216
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly His Leu Pro Thr Gly Ile His Gly Ala Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Phe Val Leu Phe Lys Asn Ala Thr Ala Phe His Val 
            20                  25                  30          


Thr Val Gln Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
        35                  40                  45              


Val Ile Ser Pro Ala Ser Val Tyr Val Val Lys Ile Thr Gly Glu Ser 
    50                  55                  60                  


Lys Asn Tyr Phe Phe Glu Phe Glu Glu Phe Asn Ser Thr Leu Pro Pro 
65                  70                  75                  80  


Pro Val Ile Phe Lys Ala Ser Tyr His Gly Leu Tyr Tyr Ile Ile Thr 
                85                  90                  95      


Leu Val Val Val Asn Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
            100                 105                 110         


Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
        115                 120                 125             


Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
    130                 135                 140                 


Glu Lys Tyr Asn Val Phe Thr Arg Val Asn Ile Ser Tyr Trp Glu Gly 
145                 150                 155                 160 


Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Phe Lys Gly Lys Thr 
                165                 170                 175     


Val Phe Asn His Trp Leu Pro Gly Met Cys Tyr Ser Asn Ile Thr Phe 
            180                 185                 190         


Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Tyr 
        195                 200                 205             


Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
    210                 215                 220                 


Pro Gln Asn Ile Ser Val Arg Ile Val Asn Leu Asn Lys Asn Asn Trp 
225                 230                 235                 240 


Glu Glu Gln Ser Gly Asn Phe Pro Glu Glu Ser Phe Met Arg Ser Gln 
                245                 250                 255     


Asp Thr Ile Gly Lys Glu Lys Leu Phe His Phe Thr Glu Glu Thr Pro 
            260                 265                 270         


Glu Ile Pro Ser Gly Asn Ile Ser Ser Gly Trp Pro Asp Phe Asn Ser 
        275                 280                 285             


Ser Asp Tyr Glu Thr Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
    290                 295                 300                 


Ala Ala Pro Glu Ser Glu Asp Glu Phe Val Ser Val Leu Pro Met Glu 
305                 310                 315                 320 


Tyr Glu Asn Asn Ser Thr Leu Ser Glu Thr Glu Lys Ser Thr Ser Gly 
                325                 330                 335     


Ser Phe Ser Phe Phe Pro Val Gln Met Ile Leu Thr Trp Leu Pro Pro 
            340                 345                 350         


Lys Pro Pro Thr Ala Phe Asp Gly Phe His Ile His Ile Glu Arg Glu 
        355                 360                 365             


Glu Asn Phe Thr Glu Tyr Leu Met Val Asp Glu Glu Ala His Glu Phe 
    370                 375                 380                 


Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Lys Leu Ser Val Thr Thr 
385                 390                 395                 400 


Phe Ser Ser Ser Gly Ser Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                405                 410                 415     


Ser Leu Ser Phe Tyr Ile Ser Pro Ser Gly Glu Trp Ile Glu Glu Leu 
            420                 425                 430         


Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
        435                 440                 445             


Ala Leu Met Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
    450                 455                 460                 


Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
465                 470                 475                 480 


Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Ile Ile 
                485                 490                 495     


Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Ile Tyr Leu Arg 
            500                 505                 510         


Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
        515                 520                 525             


Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
    530                 535                 540                 


Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
545                 550                 555                 560 


Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Ala Thr Met Thr Ser Glu 
                565                 570                 575     


Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ala Ser 
            580                 585                 590         


Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
        595                 600                 605             


Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
    610                 615                 620                 


Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
625                 630                 635                 640 


Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Asp 
                645                 650                 655     


Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
            660                 665                 670         


Glu Gly Lys Lys Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
        675                 680                 685             


Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
    690                 695                 700                 


Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
705                 710                 715                 720 


Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                725                 730                 735     


Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
            740                 745                 750         


Glu Val Phe Cys Gln Gln Val Gly Ser Ser Gln Lys Thr Lys Leu Gln 
        755                 760                 765             


Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
    770                 775                 780                 


Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
785                 790                 795                 800 


Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Met 
                805                 810                 815     


Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Thr Leu 
            820                 825                 830         


Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile Leu Arg Lys Lys His 
        835                 840                 845             


Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
    850                 855                 860                 


Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn Trp Arg Arg Ser Ile 
865                 870                 875                 880 


Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu Trp Thr Asp Tyr Leu 
                885                 890                 895     


Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn Gly Leu Lys Lys Arg 
            900                 905                 910         


Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp Ala Tyr Ile Lys 
        915                 920                 925             


Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu Gln Phe Glu Glu 
    930                 935                 940                 


Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala Ala Asp Leu Pro 
945                 950                 955                 960 


Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu Pro Tyr Asp Phe 
                965                 970                 975     


Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu Gly Ala Asp Tyr 
            980                 985                 990         


Ile Asn Ala Asn Tyr Ile Pro Gly  Tyr Asn Ser Pro Gln  Glu Tyr Ile 
        995                 1000                 1005             


Ala Thr  Gln Gly Pro Leu Pro  Glu Thr Arg Asn Asp  Phe Trp Lys 
    1010                 1015                 1020             


Met Val  Leu Gln Gln Lys Ser  Gln Ile Ile Val Met  Leu Thr Gln 
    1025                 1030                 1035             


Cys Asn  Glu Lys Arg Arg Val  Lys Cys Asp His Tyr  Trp Pro Phe 
    1040                 1045                 1050             


Thr Glu  Glu Pro Ile Ala Tyr  Gly Asp Ile Thr Val  Glu Met Ile 
    1055                 1060                 1065             


Ser Glu  Glu Glu Gln Asp Asp  Trp Ala Cys Arg His  Phe Arg Ile 
    1070                 1075                 1080             


Asn Tyr  Ala Asp Glu Met Gln  Asp Val Met His Phe  Asn Tyr Thr 
    1085                 1090                 1095             


Ala Trp  Pro Asp His Gly Val  Pro Thr Ala Asn Ala  Ala Glu Ser 
    1100                 1105                 1110             


Ile Leu  Gln Phe Val His Met  Val Arg Gln Gln Ala  Thr Lys Ser 
    1115                 1120                 1125             


Lys Gly  Pro Met Ile Ile His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1130                 1135                 1140             


Gly Thr  Phe Ile Ala Leu Asp  Arg Leu Leu Gln His  Ile Arg Asp 
    1145                 1150                 1155             


His Glu  Phe Val Asp Ile Leu  Gly Leu Val Ser Glu  Met Arg Ser 
    1160                 1165                 1170             


Tyr Arg  Met Ser Met Val Gln  Thr Glu Glu Gln Tyr  Ile Phe Ile 
    1175                 1180                 1185             


His Gln  Cys Val Gln Leu Met  Trp Met Lys Lys Lys  Gln Gln Phe 
    1190                 1195                 1200             


Cys Ile  Ser Asp Val Ile Tyr  Glu Asn Val Ser Lys  Ser 
    1205                 1210                 1215     


<210>  65
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  66
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  67
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Asp Ser Leu Ala Thr Ser Ile Asn Gln Phe Ala Leu Glu Leu Ser 
1               5                   10                  15      


Lys Lys Leu Ala Glu Ser Ala Gln Gly Lys Asn Ile Phe Phe Ser Ser 
            20                  25                  30          


Trp Ser Ile Ser Thr Ser Leu Thr Ile Val Tyr Leu Gly Ala Lys Gly 
        35                  40                  45              


Thr Thr Ala Ala Gln Met Ala Gln Val Leu Gln Phe Asn Arg Asp Gln 
    50                  55                  60                  


Gly Val Lys Cys Asp Pro Glu Ser Glu Lys Lys Arg Lys Met Glu Phe 
65                  70                  75                  80  


Asn Leu Ser Asn Ser Glu Glu Ile His Ser Asp Phe Gln Thr Leu Ile 
                85                  90                  95      


Ser Glu Ile Leu Lys Pro Asn Asp Asp Tyr Leu Leu Lys Thr Ala Asn 
            100                 105                 110         


Ala Ile Tyr Gly Glu Lys Thr Tyr Ala Phe His Asn Lys Tyr Leu Glu 
        115                 120                 125             


Asp Met Lys Thr Tyr Phe Gly Ala Glu Pro Gln Pro Val Asn Phe Val 
    130                 135                 140                 


Glu Ala Ser Asp Gln Ile Arg Lys Asp Ile Asn Ser Trp Val Glu Arg 
145                 150                 155                 160 


Gln Thr Glu Gly Lys Ile Gln Asn Leu Leu Pro Asp Asp Ser Val Asp 
                165                 170                 175     


Ser Thr Thr Arg Met Ile Leu Val Asn Ala Leu Tyr Phe Lys Gly Ile 
            180                 185                 190         


Trp Glu His Gln Phe Leu Val Gln Asn Thr Thr Glu Lys Pro Phe Arg 
        195                 200                 205             


Ile Asn Glu Thr Thr Ser Lys Pro Val Gln Met Met Phe Met Lys Lys 
    210                 215                 220                 


Lys Leu His Ile Phe His Ile Glu Lys Pro Lys Ala Val Gly Leu Gln 
225                 230                 235                 240 


Leu Tyr Tyr Lys Ser Arg Asp Leu Ser Leu Leu Ile Leu Leu Pro Glu 
                245                 250                 255     


Asp Ile Asn Gly Leu Glu Gln Leu Glu Lys Ala Ile Thr Tyr Glu Lys 
            260                 265                 270         


Leu Asn Glu Trp Thr Ser Ala Asp Met Met Glu Leu Tyr Glu Val Gln 
        275                 280                 285             


Leu His Leu Pro Lys Phe Lys Leu Glu Asp Ser Tyr Asp Leu Lys Ser 
    290                 295                 300                 


Thr Leu Ser Ser Met Gly Met Ser Asp Ala Phe Ser Gln Ser Lys Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Met Ser Ser Ala Arg Asn Leu Phe Leu Ser Asn Val 
                325                 330                 335     


Phe His Lys Ala Phe Val Glu Ile Asn Glu Gln Gly Thr Glu Ala Ala 
            340                 345                 350         


Ala Gly Ser Gly Ser Glu Ile Asn Ile Arg Ile Arg Val Pro Ser Ile 
        355                 360                 365             


Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys 
    370                 375                 380                 


Thr Asn Thr Ile Leu Phe Tyr Gly Arg Leu Cys Ser Pro 
385                 390                 395         


<210>  68
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Asp Leu Cys Val Ala Asn Thr Leu Phe Ala Leu Asn Leu Phe 
1               5                   10                  15      


Lys His Leu Ala Lys Ala Ser Pro Thr Gln Asn Leu Phe Leu Ser Pro 
            20                  25                  30          


Trp Ser Ile Ser Ser Thr Met Ala Met Val Tyr Met Gly Ser Arg Gly 
        35                  40                  45              


Ser Thr Glu Asp Gln Met Ala Lys Val Leu Gln Phe Asn Glu Val Gly 
    50                  55                  60                  


Ala Asn Ala Val Thr Pro Met Thr Pro Glu Asn Phe Thr Ser Cys Gly 
65                  70                  75                  80  


Phe Met Gln Gln Ile Gln Lys Gly Ser Tyr Pro Asp Ala Ile Leu Gln 
                85                  90                  95      


Ala Gln Ala Ala Asp Lys Ile His Ser Ser Phe Arg Ser Leu Ser Ser 
            100                 105                 110         


Ala Ile Asn Ala Ser Thr Gly Asn Tyr Leu Leu Glu Ser Val Asn Lys 
        115                 120                 125             


Leu Phe Gly Glu Lys Ser Ala Ser Phe Arg Glu Glu Tyr Ile Arg Leu 
    130                 135                 140                 


Cys Gln Lys Tyr Tyr Ser Ser Glu Pro Gln Ala Val Asp Phe Leu Glu 
145                 150                 155                 160 


Cys Ala Glu Glu Ala Arg Lys Lys Ile Tyr Ser Trp Val Lys Thr Gln 
                165                 170                 175     


Thr Lys Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly 
            180                 185                 190         


Asp Thr Arg Met Val Leu Val Asn Ala Val Tyr Phe Lys Gly Lys Trp 
        195                 200                 205             


Lys Thr Pro Phe Glu Lys Lys Leu Asn Gly Leu Tyr Pro Phe Arg Val 
    210                 215                 220                 


Asn Ser Ala Gln Arg Thr Pro Val Gln Met Met Tyr Leu Arg Glu Lys 
225                 230                 235                 240 


Leu Asn Ile Gly Tyr Ile Glu Asp Leu Lys Ala Gln Ile Leu Glu Leu 
                245                 250                 255     


Pro Tyr Ala Gly Asp Val Ser Met Phe Leu Leu Leu Pro Asp Glu Ile 
            260                 265                 270         


Ala Asp Val Ser Thr Gly Leu Glu Leu Leu Glu Ser Glu Ile Thr Tyr 
        275                 280                 285             


Asp Lys Leu Asn Lys Trp Thr Ser Lys Asp Lys Met Ala Glu Asp Glu 
    290                 295                 300                 


Val Glu Val Tyr Ile Pro Gln Phe Lys Leu Glu Glu His Tyr Glu Leu 
305                 310                 315                 320 


Arg Ser Ile Leu Arg Ser Met Gly Met Glu Asp Ala Phe Asn Lys Gly 
                325                 330                 335     


Arg Ala Asn Phe Ser Gly Met Ser Glu Arg Asn Asp Leu Phe Leu Ser 
            340                 345                 350         


Glu Val Phe His Gln Ala Met Val Asp Val Asn Glu Glu Gly Thr Glu 
        355                 360                 365             


Ala Ala Ala Gly Thr Gly Gly Val Met Thr Gly Arg Thr Gly His Gly 
    370                 375                 380                 


Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Leu Ile Met His 
385                 390                 395                 400 


Lys Ile Thr Asn Cys Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 
                405                 410                 415 


<210>  69
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Phe Pro Glu Gln Gln Lys Glu Glu Phe Val Ser Val Trp Val Arg 
1               5                   10                  15      


Asp Pro Arg Ile Gln Lys Glu Asp Phe Trp His Ser Tyr Ile Asp Tyr 
            20                  25                  30          


Glu Ile Cys Ile His Thr Asn Ser Met Cys Phe Thr Met Lys Thr Ser 
        35                  40                  45              


Cys Val Arg Arg Arg Tyr Arg Glu Phe Val Trp Leu Arg Gln Arg Leu 
    50                  55                  60                  


Gln Ser Asn Ala Leu Leu Val Gln Leu Pro Glu Leu Pro Ser Lys Asn 
65                  70                  75                  80  


Leu Phe Phe Asn Met Asn Asn Arg Gln His Val Asp Gln Arg Arg Gln 
                85                  90                  95      


Gly Leu Glu Asp Phe Leu Arg Lys Val Leu Gln Asn Ala Leu Leu Leu 
            100                 105                 110         


Ser Asp Ser Ser Leu His Leu Phe Leu Gln Ser His Leu Asn Ser Glu 
        115                 120                 125             


Asp Ile Glu Ala Cys Val Ser Gly Gln Thr Lys Tyr Ser Val Glu Glu 
    130                 135                 140                 


Ala Ile His Lys Phe Ala Leu Met Asn Arg Arg Phe Pro Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Gly Lys Lys Glu Asn Asp Ile Asp Tyr Asp Ser Glu Ser Ser 
                165                 170                 175     


Ser Ser Gly Leu Gly His Ser Ser Asp Asp Ile Ser Ser His Gly Cys 
            180                 185                 190         


Lys Val Asn Thr Ala Pro Gln Glu Ser 
        195                 200     


<210>  70
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Ile Pro Pro Pro Gln Leu 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
            20                  25                  30          


Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 
        35                  40                  45              


Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 
    50                  55                  60                  


Cys His Pro Lys Val Pro Glu Pro Cys Pro Ser Ile Val Thr Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                85                  


<210>  71
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Thr Cys Asp Ile Val Thr Glu Ala Asn Ile Ser Ser Gly Pro 
1               5                   10                  15      


Glu Ser Asn Thr Thr Gly Ile Thr Ala Phe Ser Met Pro Ser Trp Gln 
            20                  25                  30          


Leu Ala Leu Trp Ala Thr Ala Tyr Leu Ala Leu Val Leu Val Ala Val 
        35                  40                  45              


Thr Gly Asn Ala Ile Val Ile Trp Ile Ile Leu Ala His Arg Arg Met 
    50                  55                  60                  


Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Leu Ala Asp Leu 
65                  70                  75                  80  


Cys Met Ala Ala Phe Asn Ala Ala Phe Asn Phe Val Tyr Ala Ser His 
                85                  90                  95      


Asn Ile Trp Tyr Phe Gly Arg Ala Phe Cys Tyr Phe Gln Asn Leu Phe 
            100                 105                 110         


Pro Ile Thr Ala Met Phe Val Ser Ile Tyr Ser Met Thr Ala Ile Ala 
        115                 120                 125             


Ala Asp Arg Tyr Met Ala Ile Val His Pro Phe Gln Pro Arg Leu Ser 
    130                 135                 140                 


Ala Pro Ser Thr Lys Ala Val Ile Ala Gly Ile Trp Leu Val Ala Leu 
145                 150                 155                 160 


Ala Leu Ala Ser Pro Gln Cys Phe Tyr Ser Thr Val Thr Met Asp Gln 
                165                 170                 175     


Gly Ala Thr Lys Cys Val Val Ala Trp Pro Glu Asp Ser Gly Gly Lys 
            180                 185                 190         


Thr Leu Leu Leu Tyr His Leu Val Val Ile Ala Leu Ile Tyr Phe Leu 
        195                 200                 205             


Pro Leu Ala Val Met Phe Val Ala Tyr Ser Val Ile Gly Leu Thr Leu 
    210                 215                 220                 


Trp Arg Arg Ala Val Pro Gly His Gln Ala His Gly Ala Asn Leu Arg 
225                 230                 235                 240 


His Leu Gln Ala Lys Lys Lys Phe Val Lys Thr Met Val Leu Val Val 
                245                 250                 255     


Leu Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Leu Tyr Phe Ile Leu 
            260                 265                 270         


Gly Ser Phe Gln Glu Asp Ile Tyr Cys His Lys Phe Ile Gln Gln Val 
        275                 280                 285             


Tyr Leu Ala Leu Phe Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Cys Cys Leu Asn His Arg Phe Arg Ser Gly Phe Arg Leu 
305                 310                 315                 320 


Ala Phe Arg Cys Cys Pro Trp Val Thr Pro Thr Lys Glu Asp Lys Leu 
                325                 330                 335     


Glu Leu Thr Pro Thr Thr Ser Leu Ser Thr Arg Val Asn Arg Cys His 
            340                 345                 350         


Thr Lys Glu Thr Leu Phe Met Ala Gly Asp Thr Ala Pro Ser Glu Ala 
        355                 360                 365             


Thr Ser Gly Glu Ala Gly Arg Pro Gln Asp Gly Ser Gly Leu Trp Phe 
    370                 375                 380                 


Gly Tyr Gly Leu Leu Ala Pro Thr Lys Thr His Val Glu Ile 
385                 390                 395             


<210>  72
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ser Pro Arg Thr Val Thr Ile Val Ala Leu Ser Val Ala Leu 
1               5                   10                  15      


Gly Leu Phe Phe Val Phe Met Gly Thr Ile Lys Leu Thr Pro Arg Leu 
            20                  25                  30          


Ser Lys Asp Ala Tyr Ser Glu Met Lys Arg Ala Tyr Lys Ser Tyr Val 
        35                  40                  45              


Arg Ala Leu Pro Leu Leu Lys Lys Met Gly Ile Asn Ser Ile Leu Leu 
    50                  55                  60                  


Arg Lys Ser Ile Gly Ala Leu Glu Val Ala Cys Gly Ile Val Met Thr 
65                  70                  75                  80  


Leu Val Pro Gly Arg Pro Lys Asp Val Ala Asn Phe Phe Leu Leu Leu 
                85                  90                  95      


Leu Val Leu Ala Val Leu Phe Phe His Gln Leu Val Gly Asp Pro Leu 
            100                 105                 110         


Lys Arg Tyr Ala His Ala Leu Val Phe Gly Ile Leu Leu Thr Cys Arg 
        115                 120                 125             


Leu Leu Ile Ala Arg Lys Pro Glu Asp Arg Ser Ser Glu Lys Lys Pro 
    130                 135                 140                 


Leu Pro Gly Asn Ala Glu Glu Gln Pro Ser Leu Tyr Glu Lys Ala Pro 
145                 150                 155                 160 


Gln Gly Lys Val Lys Val Ser 
                165         


<210>  73
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  74
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Ala Ala Arg Ala Leu Arg Leu Leu Leu Val Val Cys Gly Cys 
1               5                   10                  15      


Leu Ala Leu Pro Pro Leu Ala Glu Pro Val Cys Pro Glu Arg Cys Asp 
            20                  25                  30          


Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Val 
        35                  40                  45              


Val Pro Lys Thr Ser Ser Leu Pro Ser Pro His Asp Val Leu Thr Tyr 
    50                  55                  60                  


Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His 
65                  70                  75                  80  


Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg 
                85                  90                  95      


Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu 
            100                 105                 110         


Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Ala Pro Gly Thr Leu Ala 
        115                 120                 125             


Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Ser 
    130                 135                 140                 


Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu 
145                 150                 155                 160 


Arg Leu Asp Gly Asn Ala Leu Gly Ala Leu Pro Asp Ala Val Phe Ala 
                165                 170                 175     


Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg 
            180                 185                 190         


Phe Leu Gly Lys Asn Ala Phe Ala Gln Leu Gly Lys Leu Arg Phe Leu 
        195                 200                 205             


Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr 
    210                 215                 220                 


Phe Ala Pro Leu Arg Ser Leu Ser Ser Leu Ile Leu Ser Ala Asn Asn 
225                 230                 235                 240 


Leu Gln His Leu Gly Pro Arg Ile Phe Gln His Leu Pro Arg Leu Gly 
                245                 250                 255     


Leu Leu Ser Leu Arg Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala 
            260                 265                 270         


Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg 
        275                 280                 285             


Leu Ser Gln Leu Pro Thr Ala Leu Leu Glu Pro Leu His Ser Leu Glu 
    290                 295                 300                 


Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr 
305                 310                 315                 320 


Phe Gly His Leu Gly Arg Leu Arg Glu Leu Ser Leu Arg Asn Asn Ala 
                325                 330                 335     


Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr 
            340                 345                 350         


Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg 
        355                 360                 365             


Gly Leu Lys Arg Trp Met Gly Asp Trp His Ser Gln Gly Arg Leu Leu 
    370                 375                 380                 


Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr 
385                 390                 395                 400 


Leu Asp Tyr Leu Asp Asp Gln Gln Leu Gln Asn Gly Ser Cys Ala Asp 
                405                 410                 415     


Pro Ser Pro Ser Ala Ser Leu Thr Ala Asp Arg Arg Arg Gln Pro Leu 
            420                 425                 430         


Pro Thr Ala Ala Gly Glu Glu Met Thr Pro Pro Ala Gly Leu Ala Glu 
        435                 440                 445             


Glu Leu Pro Pro Gln Pro Gln Leu Gln Gln Gln Gly Arg Phe Leu Ala 
    450                 455                 460                 


Gly Val Ala Trp Asp Gly Ala Ala Arg Glu Leu Val Gly Asn Arg Ser 
465                 470                 475                 480 


Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Leu Gln Gln Pro Ser Pro 
                485                 490                 495     


Ser Val Ala Ala Ala Ala Gly Pro Ala Pro Gln Ser Leu Asp Leu His 
            500                 505                 510         


Lys Lys Pro Gln Arg Gly Arg Pro Thr Arg Ala Asp Pro Ala Leu Ala 
        515                 520                 525             


Glu Pro Thr Pro Thr Ala Ser Pro Gly Ser Ala Pro Ser Pro Ala Gly 
    530                 535                 540                 


Asp Pro Trp Gln Arg Ala Thr Lys His Arg Leu Gly Thr Glu His Gln 
545                 550                 555                 560 


Glu Arg Ala Ala Gln Ser Asp Gly Gly Ala Gly Leu Pro Pro Leu Val 
                565                 570                 575     


Ser Asp Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val 
            580                 585                 590         


Glu Ala Val Gly Ala Asp Ser Ala Ser Val Arg Trp Ala Val Arg Glu 
        595                 600                 605             


His Arg Ser Pro Arg Pro Leu Gly Gly Ala Arg Phe Arg Leu Leu Phe 
    610                 615                 620                 


Asp Arg Phe Gly Gln Gln Pro Lys Phe His Arg Phe Val Tyr Leu Pro 
625                 630                 635                 640 


Glu Ser Ser Asp Ser Ala Thr Leu Arg Glu Leu Arg Gly Asp Thr Pro 
                645                 650                 655     


Tyr Leu Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val 
            660                 665                 670         


Ala Pro Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly 
        675                 680                 685             


Ser Arg Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Ala Leu Leu Thr 
    690                 695                 700                 


Val Asn Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Ala Ser Arg 
705                 710                 715                 720 


Trp Leu Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val 
                725                 730                 735     


His Val Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly 
            740                 745                 750         


Thr Gly Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg 
        755                 760                 765             


Thr Thr Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys 
    770                 775                 780                 


Asp Arg Phe Met Asp Ser Ala Gly Gly Gly Ala Gly Gly Ser Leu Arg 
785                 790                 795                 800 


Arg Glu Asp Arg Leu Leu Gln Arg Phe Ala Asp 
                805                 810     


<210>  75
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  76
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Arg Thr Gln Ser Leu Leu Leu Leu Gly Ala Leu Leu Ala Val Gly 
1               5                   10                  15      


Ser Gln Leu Pro Ala Val Phe Gly Arg Lys Lys Gly Glu Lys Ser Gly 
            20                  25                  30          


Gly Cys Pro Pro Asp Asp Gly Pro Cys Leu Leu Ser Val Pro Asp Gln 
        35                  40                  45              


Cys Val Glu Asp Ser Gln Cys Pro Leu Thr Arg Lys Cys Cys Tyr Arg 
    50                  55                  60                  


Ala Cys Phe Arg Gln Cys Val Pro Arg Val Ser Val Lys Leu Gly Ser 
65                  70                  75                  80  


Cys Pro Glu Asp Gln Leu Arg Cys Leu Ser Pro Met Asn His Leu Cys 
                85                  90                  95      


His Lys Asp Ser Asp Cys Ser Gly Lys Lys Arg Cys Cys His Ser Ala 
            100                 105                 110         


Cys Gly Arg Asp Cys Arg Asp Pro Ala Arg Gly 
        115                 120             


<210>  77
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Asn Ala Pro Leu Gly Gly Ile Trp Leu Trp Leu Pro Leu Leu Leu 
1               5                   10                  15      


Thr Trp Leu Thr Pro Glu Val Asn Ser Ser Trp Trp Tyr Met Arg Ala 
            20                  25                  30          


Thr Gly Gly Ser Ser Arg Val Met Cys Asp Asn Val Pro Gly Leu Val 
        35                  40                  45              


Ser Ser Gln Arg Gln Leu Cys His Arg His Pro Asp Val Met Arg Ala 
    50                  55                  60                  


Ile Ser Gln Gly Val Ala Glu Trp Thr Ala Glu Cys Gln His Gln Phe 
65                  70                  75                  80  


Arg Gln His Arg Trp Asn Cys Asn Thr Leu Asp Arg Asp His Ser Leu 
                85                  90                  95      


Phe Gly Arg Val Leu Leu Arg Ser Ser Arg Glu Ser Ala Phe Val Tyr 
            100                 105                 110         


Ala Ile Ser Ser Ala Gly Val Val Phe Ala Ile Thr Arg Ala Cys Ser 
        115                 120                 125             


Gln Gly Glu Val Lys Ser Cys Ser Cys Asp Pro Lys Lys Met Gly Ser 
    130                 135                 140                 


Ala Lys Asp Ser Lys Gly Ile Phe Asp Trp Gly Gly Cys Ser Asp Asn 
145                 150                 155                 160 


Ile Asp Tyr Gly Ile Lys Phe Ala Arg Ala Phe Val Asp Ala Lys Glu 
                165                 170                 175     


Arg Lys Gly Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg 
            180                 185                 190         


Ala Gly Arg Lys Ala Val Lys Arg Phe Leu Lys Gln Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Thr Leu Arg Thr Cys Trp Leu Ala Met 
    210                 215                 220                 


Ala Asp Phe Arg Lys Thr Gly Asp Tyr Leu Trp Arg Lys Tyr Asn Gly 
225                 230                 235                 240 


Ala Ile Gln Val Val Met Asn Gln Asp Gly Thr Gly Phe Thr Val Ala 
                245                 250                 255     


Asn Glu Arg Phe Lys Lys Pro Thr Lys Asn Asp Leu Val Tyr Phe Glu 
            260                 265                 270         


Asn Ser Pro Asp Tyr Cys Ile Arg Asp Arg Glu Ala Gly Ser Leu Gly 
        275                 280                 285             


Thr Ala Gly Arg Val Cys Asn Leu Thr Ser Arg Gly Met Asp Ser Cys 
    290                 295                 300                 


Glu Val Met Cys Cys Gly Arg Gly Tyr Asp Thr Ser His Val Thr Arg 
305                 310                 315                 320 


Met Thr Lys Cys Gly Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys 
                325                 330                 335     


Gln Asp Cys Leu Glu Ala Leu Asp Val His Thr Cys Lys Ala Pro Lys 
            340                 345                 350         


Asn Ala Asp Trp Thr Thr Ala Thr 
        355                 360 


<210>  78
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  79
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  80
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  81
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Thr Leu Arg Ala Ala Val Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ala Val Phe Gly Val Leu Gly Arg Thr Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Gly Leu Leu Asn Asp Ala Phe Gln Lys Gly Gly Pro Glu Gly 
        35                  40                  45              


Ala Thr Thr Arg Leu Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile 
    50                  55                  60                  


Pro Leu Met Glu Glu Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val 
65                  70                  75                  80  


Cys Leu Pro Lys Asn Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile 
                85                  90                  95      


Ser Ala Arg Lys Ile Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu 
            100                 105                 110         


Arg Lys Lys Gly Phe Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp 
        115                 120                 125             


Asp Arg Ala Glu Arg Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys 
    130                 135                 140                 


Met His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser 
                165                 170                 175     


Pro Ser Glu Val Val Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr 
        195                 200                 205             


Ala Leu Lys Glu Leu Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr 
    210                 215                 220                 


Pro Ala Pro Leu Pro Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly 
225                 230                 235                 240 


Tyr Val Thr Val Lys Pro Arg Val Arg Leu His Phe Val Glu Leu Gly 
                245                 250                 255     


Ser Gly Pro Ala Val Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr 
            260                 265                 270         


Ser Trp Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val 
        275                 280                 285             


Leu Ala Met Asp Met Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu 
    290                 295                 300                 


Ile Glu Glu Tyr Cys Met Glu Val Leu Cys Lys Glu Met Val Thr Phe 
305                 310                 315                 320 


Leu Asp Lys Leu Gly Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp 
                325                 330                 335     


Gly Gly Met Leu Val Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val 
            340                 345                 350         


Arg Ala Val Ala Ser Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn 
        355                 360                 365             


Met Ser Pro Leu Glu Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln 
    370                 375                 380                 


Leu Tyr Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn 
385                 390                 395                 400 


Leu Ser Arg Thr Phe Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val 
                405                 410                 415     


Leu Ser Met His Lys Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser 
            420                 425                 430         


Pro Glu Glu Pro Ser Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln 
        435                 440                 445             


Phe Tyr Val Gln Gln Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn 
    450                 455                 460                 


Trp Tyr Arg Asn Met Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu 
465                 470                 475                 480 


Gly Arg Lys Ile Leu Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp 
                485                 490                 495     


Phe Val Leu Val Pro Gln Met Ser Gln His Met Glu Asp Trp Ile Pro 
            500                 505                 510         


His Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Met 
        515                 520                 525             


Asp Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser 
    530                 535                 540                 


Asp Ala Arg Asn Pro Pro Val Val Ser Lys Met 
545                 550                 555 


