                         SEQUENCE LISTING

<110>  VICTORIA LINK LIMITED
 
<120>  METHODS OF DETECTING AND MEASURING GLUTAMINE AND ANALOGUES 
       THEREOF, AND METHODS RELATED THERETO

<130>  685 WO1

<150>  618665
<151>  2013-12-05

<150>  623117
<151>  2014-03-28

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  3849
<212>  DNA
<213>  Streptomyces lavendulae

<400>  1
atgactcttc aggagaccag cgtgctcgag cccaccctgc aggggaccac cacgttgccc       60

ggcctgctcg cccagcgggt ggccgaacac cccgaggcga tcgcggtcgc ctaccgggac      120

gacaagctca ccttccgcga gctcgcgtcc agaagcgcgg ccctcgccga ctacctggag      180

cacctcggtg tctccgccga cgactgcgtc ggcctgttcg tcgagccgtc gatcgacctg      240

atggtcggcg cctggggcat cctcaacgcc ggcgccgcgt acctgccgct gtccccggag      300

taccccgagg accggctgcg ctacatgatc gagaacagcg agacgaagat catcctggcg      360

cagcagcgcc tggtgtcccg tctgcgcgag ctcgcgccga aggacgtcac catcgtgacc      420

ctgcgcgagt ccgaggcctt cgtccgcccc gagggcaccg aggccccggc cgcccgcagc      480

gcccgcccgg acaccctcgc gtacgtcatc tacacctccg gcagcacggg caagccgaag      540

ggtgtgatga tcgagcaccg cagcatcgtc aaccagctcg gctggctgcg cgagacctac      600

gcgatcgacc gcagcaaggt catcctccag aagaccccga tgagcttcga cgccgcccag      660

tgggagatcc tctccccggc caacggcgcc accgtcgtca tgggcgcccc gggcgtctac      720

gccgaccccg agggcctcat cgagaccatc gtcaagcaca acgtgaccac cctccagtgc      780

gtcccgacgc tgctccaggg tctgatcgac accgagaagt tccccgagtg cgtctccctc      840

cagcagatct tcagcggtgg cgaggccctc tcccgcctgc tggcgatcca gaccacgcag      900

gagatgcccg gccgggcgct catcaacgtc tacgggccga ccgagacgac gatcaactcg      960

tcctcgttcc ccgtcgaccc cgccgacctg gacgagggac cgcagtccat ctccatcggc     1020

tccccggtgc acggcaccac gtaccacatc cttgacaagg agaccctcaa gccggtcggc     1080

gtcggtgaga tcggcgagct gtacatcggc ggcatccagc tggcccgcgg ctacctgcac     1140

cgcgacgacc tgaccgccga gcgcttcctg gagatcgagc tcgaggaggg cgccgagccc     1200

gtccgcctgt acaagacggg cgacctcggc cagtggaaca acgacggcac cgtgcagttc     1260

gccggccgcg ccgacaacca ggtcaagctg cgcggctacc gcgtcgagct cgacgagata     1320

tccctggcga tcgagaacca cgactgggtc cgcaacgccg ccgtcatcgt caagaacgac     1380

ggccgcaccg gcttccagaa cctgatcgcc tgcatcgagc tgagcgagaa ggaagccgcc     1440

ctgatggacc agggcaacca cggctcccac cacgcgtcga agaagagcaa gctccaggtc     1500

aaggcgcagc tgtccaaccc gggcctgcgc gacgacgccg agctggccgc ccgcccggcc     1560

ttcgacctgg agggcgccga gcccaccccc gagcagcgcg cccgggtctt cgcccgcaag     1620

acgtaccgct tctacgaggg cggcgccgtc acccaggccg acctgctggg cctgctgggc     1680

gccacggtca ccgccggcta ctcgcgcaag gcggccgacc tggcccccgc cgaactcggc     1740

cagatcctgc gctggttcgg ccagtacatc agcgaggagc ggctcctgcc gaagtacggc     1800

tacgcctccc cgggcgcgct gtacgcgacg cagatgtact tcgagctgga gggcgtcggc     1860

ggtctgaagc cgggctacta ctactaccag ccggtccgcc accagctcgt cctcatcagc     1920

gagcgcgagg ccaccggcaa ggccacggcg cagatccact tcatcggcaa gaagagcggc     1980

atcgagccgg tctacaagaa caacatcctc gaggtcctgg agatcgagac cggccacatg     2040

gtcggcctct tcgagcagat cctgccggcc tacggcctcg acatccacga ccgcgcctac     2100

gagccggccg tcaaggacct gctcgacgtc gccgacgagg actactacct gggcaccttc     2160

gagctggtcc cgcacgcggg cgcgcgcgac gaccaggccg aggtctacgt ccagacgcac     2220

ggcggaaagg tcgccggcct gcccgagggc cagtaccgct acgagaacgg cgagctgacc     2280

cgcttctcgg acgacatcgt cctcaagaag cacgtcatcg cgatcaacca gtcggtgtac     2340

caggccgcca gcttcggcat cagcgtctac agccgcgccg aggaggagtg gctgaagtac     2400

atcaccctcg gcaagaagct ccagcacctg atgatgaacg ggctgaacct gggcttcatg     2460

tcctcgggct acagctccaa gacgggcaac ccgctgccgg cctcgcgccg catggacgcc     2520

gtcctcggcg ccaacggcgt cgacagcgcc ccgatgtact tcttcgtcgg cggccgcatc     2580

agcgacgagc agatcggcca cgagggcatg cgcgaggaca gcgtccacat gcgcggtccg     2640

gccgagctca tccgcgacga cctcgtcagc ttcctcccgg actacatgat ccccaaccgg     2700

gtcgtggtct tcgaccggct gccgctgtcc gccaacggca agatcgacgt caaggcgctc     2760

gccgcctccg accaggtcaa cgccgagctc gtcgagcgcc ccttcgtcgc cccgcgcacg     2820

gagacggaga aggagatcgc ggcggtctgg gagaaggccc tgcgccgcga gaacgcctcc     2880

gtccaggacg acttcttcga gtcgggcggc aactcgctga tcgccgtcgg cctcgtccgc     2940

gagctcaacg cgcgcctggg cgtctccctg ccgctgcaga gcgtcctgga gtccccgacc     3000

atcgagaagc tggcccgccg cctggagcgc gaggtcgccc aggagtcctc gcgcttcgtc     3060

cgcctgcacg cggagaccgg caaggcccgg cccgtgatct gctggccggg tctgggcggc     3120

tacccgatga acctgcgcag cctggccggc gagatcggcc tcggccgctc gttctacggc     3180

gtccagtcct acggcatcaa cgagggcgag accccgtacg agaccatcac cgagatggcc     3240

aagaaggaca tcgaggccct caaggagatc cagccggccg gcccctacac cctgtggggc     3300

tactccttcg gcgcccgcgt ggccttcgag accgcctacc agctggagca ggcgggcgag     3360

aaggtggaca acctcttcct gatcgccccg ggctccccga aggtgcgcgc cgagaacggc     3420

aaggtgtggg gccgcgaggc gtccttcgcc aaccgcggct acaccacgat cctgttctcg     3480

gtcttcaccg gcaccatttc cggtccggac ctggaccggt gcctggagac cgtgacggac     3540

gaggcctcct tcgccgagtt catcagcgag ctcaagggaa tcgacgtcga cctcgcccgc     3600

cggatcatct cggtcgtggg ccagacgtac gaattcgagt actccttcca cgagctggcc     3660

gagcgcaccc tccaggcgcc gatcagcatc ttcaaggccg tgggcgacga ctactcgttc     3720

ctggagaaca gcagcggcta ctcggccgag ccgccgacgg tcatcgacct cgacgccgac     3780

cactacagcc tgctgcgcga ggacatcggc gagctggtga agcacatccg ctacctgctc     3840

ggcgagtga                                                             3849


<210>  2
<211>  1282
<212>  PRT
<213>  Streptomyces lavendulae

<400>  2

Met Thr Leu Gln Glu Thr Ser Val Leu Glu Pro Thr Leu Gln Gly Thr 
1               5                   10                  15      


Thr Thr Leu Pro Gly Leu Leu Ala Gln Arg Val Ala Glu His Pro Glu 
            20                  25                  30          


Ala Ile Ala Val Ala Tyr Arg Asp Asp Lys Leu Thr Phe Arg Glu Leu 
        35                  40                  45              


Ala Ser Arg Ser Ala Ala Leu Ala Asp Tyr Leu Glu His Leu Gly Val 
    50                  55                  60                  


Ser Ala Asp Asp Cys Val Gly Leu Phe Val Glu Pro Ser Ile Asp Leu 
65                  70                  75                  80  


Met Val Gly Ala Trp Gly Ile Leu Asn Ala Gly Ala Ala Tyr Leu Pro 
                85                  90                  95      


Leu Ser Pro Glu Tyr Pro Glu Asp Arg Leu Arg Tyr Met Ile Glu Asn 
            100                 105                 110         


Ser Glu Thr Lys Ile Ile Leu Ala Gln Gln Arg Leu Val Ser Arg Leu 
        115                 120                 125             


Arg Glu Leu Ala Pro Lys Asp Val Thr Ile Val Thr Leu Arg Glu Ser 
    130                 135                 140                 


Glu Ala Phe Val Arg Pro Glu Gly Thr Glu Ala Pro Ala Ala Arg Ser 
145                 150                 155                 160 


Ala Arg Pro Asp Thr Leu Ala Tyr Val Ile Tyr Thr Ser Gly Ser Thr 
                165                 170                 175     


Gly Lys Pro Lys Gly Val Met Ile Glu His Arg Ser Ile Val Asn Gln 
            180                 185                 190         


Leu Gly Trp Leu Arg Glu Thr Tyr Ala Ile Asp Arg Ser Lys Val Ile 
        195                 200                 205             


Leu Gln Lys Thr Pro Met Ser Phe Asp Ala Ala Gln Trp Glu Ile Leu 
    210                 215                 220                 


Ser Pro Ala Asn Gly Ala Thr Val Val Met Gly Ala Pro Gly Val Tyr 
225                 230                 235                 240 


Ala Asp Pro Glu Gly Leu Ile Glu Thr Ile Val Lys His Asn Val Thr 
                245                 250                 255     


Thr Leu Gln Cys Val Pro Thr Leu Leu Gln Gly Leu Ile Asp Thr Glu 
            260                 265                 270         


Lys Phe Pro Glu Cys Val Ser Leu Gln Gln Ile Phe Ser Gly Gly Glu 
        275                 280                 285             


Ala Leu Ser Arg Leu Leu Ala Ile Gln Thr Thr Gln Glu Met Pro Gly 
    290                 295                 300                 


Arg Ala Leu Ile Asn Val Tyr Gly Pro Thr Glu Thr Thr Ile Asn Ser 
305                 310                 315                 320 


Ser Ser Phe Pro Val Asp Pro Ala Asp Leu Asp Glu Gly Pro Gln Ser 
                325                 330                 335     


Ile Ser Ile Gly Ser Pro Val His Gly Thr Thr Tyr His Ile Leu Asp 
            340                 345                 350         


Lys Glu Thr Leu Lys Pro Val Gly Val Gly Glu Ile Gly Glu Leu Tyr 
        355                 360                 365             


Ile Gly Gly Ile Gln Leu Ala Arg Gly Tyr Leu His Arg Asp Asp Leu 
    370                 375                 380                 


Thr Ala Glu Arg Phe Leu Glu Ile Glu Leu Glu Glu Gly Ala Glu Pro 
385                 390                 395                 400 


Val Arg Leu Tyr Lys Thr Gly Asp Leu Gly Gln Trp Asn Asn Asp Gly 
                405                 410                 415     


Thr Val Gln Phe Ala Gly Arg Ala Asp Asn Gln Val Lys Leu Arg Gly 
            420                 425                 430         


Tyr Arg Val Glu Leu Asp Glu Ile Ser Leu Ala Ile Glu Asn His Asp 
        435                 440                 445             


Trp Val Arg Asn Ala Ala Val Ile Val Lys Asn Asp Gly Arg Thr Gly 
    450                 455                 460                 


Phe Gln Asn Leu Ile Ala Cys Ile Glu Leu Ser Glu Lys Glu Ala Ala 
465                 470                 475                 480 


Leu Met Asp Gln Gly Asn His Gly Ser His His Ala Ser Lys Lys Ser 
                485                 490                 495     


Lys Leu Gln Val Lys Ala Gln Leu Ser Asn Pro Gly Leu Arg Asp Asp 
            500                 505                 510         


Ala Glu Leu Ala Ala Arg Pro Ala Phe Asp Leu Glu Gly Ala Glu Pro 
        515                 520                 525             


Thr Pro Glu Gln Arg Ala Arg Val Phe Ala Arg Lys Thr Tyr Arg Phe 
    530                 535                 540                 


Tyr Glu Gly Gly Ala Val Thr Gln Ala Asp Leu Leu Gly Leu Leu Gly 
545                 550                 555                 560 


Ala Thr Val Thr Ala Gly Tyr Ser Arg Lys Ala Ala Asp Leu Ala Pro 
                565                 570                 575     


Ala Glu Leu Gly Gln Ile Leu Arg Trp Phe Gly Gln Tyr Ile Ser Glu 
            580                 585                 590         


Glu Arg Leu Leu Pro Lys Tyr Gly Tyr Ala Ser Pro Gly Ala Leu Tyr 
        595                 600                 605             


Ala Thr Gln Met Tyr Phe Glu Leu Glu Gly Val Gly Gly Leu Lys Pro 
    610                 615                 620                 


Gly Tyr Tyr Tyr Tyr Gln Pro Val Arg His Gln Leu Val Leu Ile Ser 
625                 630                 635                 640 


Glu Arg Glu Ala Thr Gly Lys Ala Thr Ala Gln Ile His Phe Ile Gly 
                645                 650                 655     


Lys Lys Ser Gly Ile Glu Pro Val Tyr Lys Asn Asn Ile Leu Glu Val 
            660                 665                 670         


Leu Glu Ile Glu Thr Gly His Met Val Gly Leu Phe Glu Gln Ile Leu 
        675                 680                 685             


Pro Ala Tyr Gly Leu Asp Ile His Asp Arg Ala Tyr Glu Pro Ala Val 
    690                 695                 700                 


Lys Asp Leu Leu Asp Val Ala Asp Glu Asp Tyr Tyr Leu Gly Thr Phe 
705                 710                 715                 720 


Glu Leu Val Pro His Ala Gly Ala Arg Asp Asp Gln Ala Glu Val Tyr 
                725                 730                 735     


Val Gln Thr His Gly Gly Lys Val Ala Gly Leu Pro Glu Gly Gln Tyr 
            740                 745                 750         


Arg Tyr Glu Asn Gly Glu Leu Thr Arg Phe Ser Asp Asp Ile Val Leu 
        755                 760                 765             


Lys Lys His Val Ile Ala Ile Asn Gln Ser Val Tyr Gln Ala Ala Ser 
    770                 775                 780                 


Phe Gly Ile Ser Val Tyr Ser Arg Ala Glu Glu Glu Trp Leu Lys Tyr 
785                 790                 795                 800 


Ile Thr Leu Gly Lys Lys Leu Gln His Leu Met Met Asn Gly Leu Asn 
                805                 810                 815     


Leu Gly Phe Met Ser Ser Gly Tyr Ser Ser Lys Thr Gly Asn Pro Leu 
            820                 825                 830         


Pro Ala Ser Arg Arg Met Asp Ala Val Leu Gly Ala Asn Gly Val Asp 
        835                 840                 845             


Ser Ala Pro Met Tyr Phe Phe Val Gly Gly Arg Ile Ser Asp Glu Gln 
    850                 855                 860                 


Ile Gly His Glu Gly Met Arg Glu Asp Ser Val His Met Arg Gly Pro 
865                 870                 875                 880 


Ala Glu Leu Ile Arg Asp Asp Leu Val Ser Phe Leu Pro Asp Tyr Met 
                885                 890                 895     


Ile Pro Asn Arg Val Val Val Phe Asp Arg Leu Pro Leu Ser Ala Asn 
            900                 905                 910         


Gly Lys Ile Asp Val Lys Ala Leu Ala Ala Ser Asp Gln Val Asn Ala 
        915                 920                 925             


Glu Leu Val Glu Arg Pro Phe Val Ala Pro Arg Thr Glu Thr Glu Lys 
    930                 935                 940                 


Glu Ile Ala Ala Val Trp Glu Lys Ala Leu Arg Arg Glu Asn Ala Ser 
945                 950                 955                 960 


Val Gln Asp Asp Phe Phe Glu Ser Gly Gly Asn Ser Leu Ile Ala Val 
                965                 970                 975     


Gly Leu Val Arg Glu Leu Asn Ala Arg Leu Gly Val Ser Leu Pro Leu 
            980                 985                 990         


Gln Ser Val Leu Glu Ser Pro Thr  Ile Glu Lys Leu Ala  Arg Arg Leu 
        995                 1000                 1005             


Glu Arg  Glu Val Ala Gln Glu  Ser Ser Arg Phe Val  Arg Leu His 
    1010                 1015                 1020             


Ala Glu  Thr Gly Lys Ala Arg  Pro Val Ile Cys Trp  Pro Gly Leu 
    1025                 1030                 1035             


Gly Gly  Tyr Pro Met Asn Leu  Arg Ser Leu Ala Gly  Glu Ile Gly 
    1040                 1045                 1050             


Leu Gly  Arg Ser Phe Tyr Gly  Val Gln Ser Tyr Gly  Ile Asn Glu 
    1055                 1060                 1065             


Gly Glu  Thr Pro Tyr Glu Thr  Ile Thr Glu Met Ala  Lys Lys Asp 
    1070                 1075                 1080             


Ile Glu  Ala Leu Lys Glu Ile  Gln Pro Ala Gly Pro  Tyr Thr Leu 
    1085                 1090                 1095             


Trp Gly  Tyr Ser Phe Gly Ala  Arg Val Ala Phe Glu  Thr Ala Tyr 
    1100                 1105                 1110             


Gln Leu  Glu Gln Ala Gly Glu  Lys Val Asp Asn Leu  Phe Leu Ile 
    1115                 1120                 1125             


Ala Pro  Gly Ser Pro Lys Val  Arg Ala Glu Asn Gly  Lys Val Trp 
    1130                 1135                 1140             


Gly Arg  Glu Ala Ser Phe Ala  Asn Arg Gly Tyr Thr  Thr Ile Leu 
    1145                 1150                 1155             


Phe Ser  Val Phe Thr Gly Thr  Ile Ser Gly Pro Asp  Leu Asp Arg 
    1160                 1165                 1170             


Cys Leu  Glu Thr Val Thr Asp  Glu Ala Ser Phe Ala  Glu Phe Ile 
    1175                 1180                 1185             


Ser Glu  Leu Lys Gly Ile Asp  Val Asp Leu Ala Arg  Arg Ile Ile 
    1190                 1195                 1200             


Ser Val  Val Gly Gln Thr Tyr  Glu Phe Glu Tyr Ser  Phe His Glu 
    1205                 1210                 1215             


Leu Ala  Glu Arg Thr Leu Gln  Ala Pro Ile Ser Ile  Phe Lys Ala 
    1220                 1225                 1230             


Val Gly  Asp Asp Tyr Ser Phe  Leu Glu Asn Ser Ser  Gly Tyr Ser 
    1235                 1240                 1245             


Ala Glu  Pro Pro Thr Val Ile  Asp Leu Asp Ala Asp  His Tyr Ser 
    1250                 1255                 1260             


Leu Leu  Arg Glu Asp Ile Gly  Glu Leu Val Lys His  Ile Arg Tyr 
    1265                 1270                 1275             


Leu Leu  Gly Glu 
    1280         


