                         SEQUENCE LISTING

<110>  INNOVATIVE TARGETING SOLUTIONS INC.
 
<120>  G-PROTEIN COUPLED RECEPTOR AGONISTS AND METHODS

<130>  V86880WO

<140>  n/a
<141>  2014-12-04

<150>  61/911,829
<151>  2013-12-04

<150>  62/043,874
<151>  2014-08-29

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  7855
<212>  DNA
<213>  Artificial sequence

<220>
<223>  vector E425

<400>  1
tcgacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga       60

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc      120

taaagtatat atgagtaaac ttggtctgac agttattatt tacccaccac tttggtaatt      180

tcgcctttca cgtaatgcac aaattcttcc agctgatccg cacggctggc cagacgatct      240

tcttcctggc ccagatacgc ctgacgcgct tccagaatca ccggctgata ctgcgccggc      300

agacgttcca tggcccaatc cgccgccaca tctttcggcg caattttgcc ggtcaccgcg      360

ctataccaaa tacggctcag ggtcagcacc acgttgcgtt catcacccgc ccaatccggc      420

gggctgttcc acagggtcag ggtttcgttc agcgcttcaa acaggtcctg ttccggcacc      480

ggatcaaaca gttcttccgc tgccggacca accagcgcca cgctatgttc acgcgctttg      540

gtcagcagaa tggccagatc gatatcaatg gtcgccggtt caaaaatgcc ggccagaata      600

tcgttacgct gccattcgcc aaactgcagc tcacgtttcg ccggataacg ccacggaata      660

atgtcatcat gcaccacgat ggtcacttcc accgcacgca gaatttcgct ttcacccggg      720

ctcgcgctgg tttccagcag atcgttaatc agcgcacgac gggtggtttc atccagacgc      780

acggtcacgg tcaccagcag atcaatatcg ctatgcggtt tcaggccgcc atccaccgcg      840

ctgccataca gatgcacggc cagcagggtc ggttccagat gacgttcaat cacgcccacc      900

acttcagaca gctgggtgct cacttccgca atcaccgctt cacgcataat gttcagtttg      960

gttttcggac ggctgccctg ctgggtcaca tcgttgctgc tccacagcat caggcaacgg     1020

cccaccgcat aacgcgcctg ctgtttgctc gcacgcggca tgctctgcac gccaaaaaag     1080

caatcatagc acgccataaa caccgccacc gcaccattac cgccgctacg ttcggtcagg     1140

gtacggctcc aattacggct acgcatactc ttcctttttc aatattattg aagcatttat     1200

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     1260

ggggttccgc gcacatttcc ccgaaaagtg ccacctaaat tgtaagcgtt aatattttgt     1320

taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg     1380

gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtggc cgctacaggg     1440

cgctcccatt cgccattcag gctgcgcaac tgttgggaag ggcgtttcgg tgcgggcctc     1500

ttcgctatta cgccagctgg cgaaaggggg atgtgctgca aggcgattaa gttgggtaac     1560

gccagggttt tcccagtcac gacgttgtaa aacgacggcc agtgagcgcg acgtaatacg     1620

actcactata gggcgaattg agtgaaggcc gtcaaggcct attgctcgat gagacgtctt     1680

aattaactgg cctcatgggc cttcacttca ctgcccgctt tccagtcggg aaacctgtcg     1740

tgccagctgc attaacatgg tcatagctgt ttccttgcgt attgggcgct ctccgcttcc     1800

tcgctcactg actcgctgcg ctcggtcgtt cgggtaaagc ctggggtgcc taatgagcaa     1860

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     1920

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     1980

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     2040

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     2100

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     2160

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     2220

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     2280

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     2340

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     2400

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     2460

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     2520

cggcgcgcct gaataacttc gtatagcata cattatagca atttatcgaa aaagcctgaa     2580

ctcaccgcga catccgtgga gaaattcctc atcgaaaaat tcgactccgt gtccgatctc     2640

atgcagctgt ccgagggcga ggagagtaga gcattctcat tcgatgtggg cgggagaggc     2700

tacgtgctga gagtgaactc ttgtgccgac ggcttctaca aggaccgata cgtctaccgg     2760

cattttgctt ccgccgctct gcctattcca gaagtcctgg acattgggga gtttagcgag     2820

tccctcactt actgtattag ccggcgagcc cagggagtga cactccagga tctgcctgaa     2880

actgaactgc ctgctgtgct ccagcctgtc gctgaggcaa tggatgctat tgctgctgcc     2940

gatctgagtc agactagcgg attcggccca tttggacccc agggcattgg ccagtacaca     3000

acatggcgag acttcatctg tgctatcgcc gatcctcacg tgtaccattg gcagactgtg     3060

atggacgata ctgtgtctgc ttctgtggca caggcactcg acgaactcat gctgtgggct     3120

gaggactgtc ctgaagtgag acatctggtc catgccgatt ttggctccaa caatgtgctc     3180

accgataacg ggagaatcac tgccgtgatc gactggagcg aggcaatgtt tggcgattcc     3240

cagtacgaag tggccaacat cttcttttgg cggccttggc tggcttgtat ggaacagcag     3300

acccggtact ttgaacggcg ccaccctgag ctggctggga gtcctagact gagagcctac     3360

atgctccgaa ttggcctgga tcagctctac cagtcactgg tggatggcaa tttcgacgat     3420

gctgcttggg cacaggggcg ctgtgatgct attgtccgat ccggcgctgg aactgtgggg     3480

agaacacaga tcgctaggag atccgctgct gtctggaccg atggatgtgt ggaagtgctg     3540

gccgatagtg gaaaccggag gccttcaacc cgaccccggg caaaggagta atgaccgttt     3600

aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     3660

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     3720

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     3780

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     3840

ctatggggat cccgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg     3900

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     3960

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     4020

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     4080

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     4140

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     4200

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     4260

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     4320

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     4380

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     4440

ctctctggct aactagagaa cccactgctt actggcttat cgaaattaat acgactcact     4500

atagggagac acaagctggc ggccgctctc ggaaggtctc tatgttgatc ctttttaacc     4560

catcacatat acctgccgtt cactattatt tagtgaaatg agatattatg atattttctg     4620

aattgtgatt aaaaaggcaa ctttatgccc atgcaacaga aactataaaa aatacagaga     4680

atgaaaagaa acagatagat tttttagttc tttaggcccg tagtctgcaa atccttttat     4740

gattttctat caaacaaaag aggaaaatag accagttgca atccaaacga gagtctaata     4800

gaatgaggtc gaaaagtaaa tcgcgcgggt ttgttactga taaagcaggc aagacctaaa     4860

atgtgtaaag ggcaaagtgt atactttggc gtcacccctt acatatttta ggtctttttt     4920

tattgtgcgt aactaacttg ccatcttcaa acaggagggc tggaagaagc agaccgctaa     4980

cacagtacat aaaaaaggag acatgaacga tgaacatcaa aaagtttgca aaacaagcaa     5040

cagtattaac ctttactacc gcactgctgg caggaggcgc aactcaagcg tttgcgaaag     5100

aaacgaacca aaagccatat aaggaaacat acggcatttc ccatattaca cgccatgata     5160

tgctgcaaat ccctgaacag caaaaaaatg aaaaatatca agttcctgag ttcgattcgt     5220

ccacaattaa aaatatctct tctgcaaaag gcctggacgt ttgggacagc tggccattac     5280

aaaacgctga cggcactgtc gcaaactatc acggctacca catcgtcttt gcattagccg     5340

gagatcctaa aaatgcggat gacacatcga tttacatgtt ctatcaaaaa gtcggcgaaa     5400

cttctattga cagctggaaa aacgctggcc gcgtctttaa agacagcgac aaattcgatg     5460

caaatgattc tatcctaaaa gaccaaacac aagaatggtc aggttcagcc acatttacat     5520

ctgacggaaa aatccgttta ttctacactg atttctccgg taaacattac ggcaaacaaa     5580

cactgacaac tgcacaagtt aacgtatcag catcagacag ctctttgaac atcaacggtg     5640

tagaggatta taaatcaatc tttgacggtg acggaaaaac gtatcaaaat gtacagcagt     5700

tcatcgatga aggcaactac agctcaggcg acaaccatac gctgagagat cctcactacg     5760

tagaagataa aggccacaaa tacttagtat ttgaagcaaa cactggaact gaagatggct     5820

accaaggcga agaatcttta tttaacaaag catactatgg caaaagcaca tcattcttcc     5880

gtcaagaaag tcaaaaactt ctgcaaagcg ataaaaaacg cacggctgag ttagcaaacg     5940

gcgctctcgg tatgattgag ctaaacgatg attacacact gaaaaaagtg atgaaaccgc     6000

tgattgcatc taacacagta acagatgaaa ttgaacgcgc gaacgtcttt aaaatgaacg     6060

gcaaatggta tctgttcact gactcccgcg gatcaaaaat gacgattgac ggcattacgt     6120

ctaacgatat ttacatgctt ggttatgttt ctaattcttt aactggccca tacaagccgc     6180

tgaacaaaac tggccttgtg ttaaaaatgg atcttgatcc taacgatgta acctttactt     6240

actcacactt cgctgtacct caagcgaaag gaaacaatgt cgtgattaca agctatatga     6300

caaacagagg attctacgca gacaaacaat caacgtttgc gcctagcttc ctgctgaaca     6360

tcaaaggcaa gaaaacatct gttgtcaaag acagcatcct tgaacaagga caattaacag     6420

ttaacaaata aaaacgcaaa agaaaatgcc gattatggtg cactctcagt acaatctggt     6480

ctctcaggcg ccctgaccag cggcgtgcat accttcccgg ctgtcctaca gtcctcagga     6540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     6600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     6660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     6720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctctag aacccctgag     6780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     6840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     6900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     6960

tacaagtgca aggtgtccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     7020

gccaaaggtg ggacccgtgg ggtgcgaata gaagttccta ttccgaagtt cctattctct     7080

agaaagtata ggaacttcgg gccacatgga attaattcag aggccggctc ggcccaccct     7140

ctgccctgag agtgaccgct gtaccaacct ctgtccctac agggcagccc cgagaaccac     7200

aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct     7260

gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc     7320

cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct     7380

acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg     7440

tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggca     7500

aagctgtggg ccaggacacg caggaggtca tcgtggtgcc acactccttg ccctttaagg     7560

tggtggtgat ctcagccatc ctggccctgg tggtgctcac catcatctcc cttatcatcc     7620

tcatcatgct ttggcagaag aagccacgtt aggttttccg ggacgccggc tggatgatcc     7680

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     7740

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     7800

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgacc          7855


<210>  2
<211>  1704
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR product


<220>
<221>  misc_feature
<222>  (118)..(125)
<223>  n is a, c, g, or t

<400>  2
catggcgagg gcaccttcac ctccgacctg tccaaacaaa tggaagaaga agccgtccgg       60

ctgttcatcg aatggctgaa aaatggcggc ccttcctctg gcgcccctcc tccttctnnn      120

nnnnnctggt tcgacccctg gggccaggga accctggtca ccgtgtcctc agcctccacc      180

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      240

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      300

ggcgccctga ccagcggcgt gcataccttc ccggctgtcc tacagtcctc aggactctac      360

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      420

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      480

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      540

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct ctagaacccc tgaggtcaca      600

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      660

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      720

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      780

tgcaaggtgt ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      840

ggtgggaccc gtggggtgcg aatagaagtt cctattccga agttcctatt ctctagaaag      900

tataggaact tcgggccaca tggaattaat tcagaggccg gctcggccca ccctctgccc      960

tgagagtgac cgctgtacca acctctgtcc ctacagggca gccccgagaa ccacaggtgt     1020

acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg     1080

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1140

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1200

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1260

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggcaaagctg     1320

tgggccagga cacgcaggag gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg     1380

tgatctcagc catcctggcc ctggtggtgc tcaccatcat ctcccttatc atcctcatca     1440

tgctttggca gaagaagcca cgttaggttt tccgggacgc cggctggatg atcctccagc     1500

gcggggatct catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg     1560

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     1620

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgacct cgacggggtc     1680

tgacgctcag tggaacgaaa actc                                            1704


<210>  3
<211>  1630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  fragment derived from P163


<220>
<221>  misc_feature
<222>  (727)..(1026)
<223>  n is a, c, g, or t

<400>  3
ggatcccgcg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat       60

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg      120

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa      180

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact      240

tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta      300

aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt      360

acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg      420

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg      480

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc      540

cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctctct      600

ggctaactag agaacccact gcttactgct cgacgatctg atcaagagac aggataagga      660

gccgccacca tggagtttgg gctgagctgg ctttttcttg tggctatttt aaaaggtgtc      720

cagtgtnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      840

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1020

nnnnnncaca gtggtagtac tccactgtct gggtgtacaa aaacctccct gcacgcctct     1080

ctaacctcac aattctgtgg cggccgcgcc gccaccatga ttgaacaaga tggattgcac     1140

gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca     1200

atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt     1260

gtcaagaccg acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg     1320

tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga     1380

agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct     1440

cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg     1500

gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg     1560

gaagccggtc ttgtcgatca ggtgagtaca ggaggtggag agtacgcgta acacttaagc     1620

gtctctccaa                                                            1630


<210>  4
<211>  2423
<212>  DNA
<213>  Artificial sequence

<220>
<223>  vector V610 digested with KpnI and BsaI

<400>  4
ggtacctctt aattaactgg cctcatgggc cttccgctca ctgcccgctt tccagtcggg       60

aaacctgtcg tgccagctgc attaacatgg tcatagctgt ttccttgcgt attgggcgct      120

ctccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cgggtaaagc ctggggtgcc      180

taatgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc      900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa      960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1140

gaaccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     1740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     1800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     1860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     1920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     1980

gtgccaccta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat ttttgttaaa     2040

tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa tcaaaagaat     2100

agaccgagat agggttgagt ggccgctaca gggcgctccc attcgccatt caggctgcgc     2160

aactgttggg aagggcgttt cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg     2220

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg     2280

taaaacgacg gccagtgagc gcgacgtaat acgactcact atagggcgaa ttggcggaag     2340

gccgtcaagg cctaggcgcg cccgtctctc caagtgcaaa gggacaggag gtttttgtta     2400

agggctgtat cactgtggag acc                                             2423


<210>  5
<211>  8514
<212>  DNA
<213>  Artificial sequence

<220>
<223>  acceptor vector E501

<400>  5
cagactgccc cggggcagtt aggagatccg ggggccgccg ggaactgccg ctggcccccc       60

accgccccaa ggatctcccg gtccccgccc ggcgtgctga cgtcacggcg ctgccccagg      120

gtgtgctggg caggtcgcgg ggagcgctgg gaaatggagt ccattagcag aagtggccct      180

tggccacttc caggagtcgc tgtgccccga tgcacactgg gaagtccgca gctccgaggc      240

gcccagtgga aatcgccaga tgagggcctc ctccggggaa tgctgggaaa tggagtctac      300

aggccggagg ggtgccccac ggcatactag gaagtgtgta gcaccgggta aaggggatga      360

atagcagact gccccggggc agttaggaga tccgggggcc gccgggaact gccgctggcc      420

ccccaccgcc ccaaggatct cccggtcccc gcccggcgtg ctgacgtcac ggcgctgccc      480

cagggtgtgc tgggcaggtc gcggggagcg ctgggaaatg gagtccatta gcagaagtgg      540

cccttggcca cttccaggag tcgctgtgcc ccgatgcaca ctgggaagtc cgcagctccg      600

aggcgcccag tggaaatcgc cagatgaggg cctcctccgg ggaatgctgg gaaatggagt      660

ctacaggccg gaggggtgcc ccacggcata ctaggaagtg tgtagcaccg ggtaaagggg      720

atgaatagca gactgccccg gggcagttag gagatccggg ggccgccggg aactgccgct      780

ggccccccac cgccccaagg atctcccggt ccccgcccgg cgtgctgacg tcacggcgct      840

gccccagggt gtgctgggca ggtcgcgggg agcgctggga aatggagtcc attagcagaa      900

gtggcccttg gccacttcca ggagtcgctg tgccccgatg cacactggga agtccgcagc      960

tccgaggcgc ccagtggaaa tcgccagatg agggcctcct ccggggaatg ctgggaaatg     1020

gagtctacag gccggagggg tgccccacgg catactagga agtgtgtagc accgggtaaa     1080

ggggatgaat agcagactgc cccggggcag ttaggagatc cctcatgggc cttcctttca     1140

ctgcactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga     1200

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg     1260

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg     1320

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca     1380

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     1440

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc     1500

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc     1560

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa     1620

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag     1680

gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag aacccactgc     1740

ttactggctt atcgaaatta atacgactca ctatagggag acccaagctg gctagcgttt     1800

aaacttaagc ttgaggagcc gccaccatgg acatgagggt ccccgctcag ctcctggggc     1860

tcctgctact ctggctccga ggtaaggatg gagaacacta ggaatttact cagccagtgt     1920

gctcagtact gactggaact tcagggaagt tctctgataa catgattaat agtaagaata     1980

tttgttttta tgtttccaat ctcaggtgcc agatgtgaca tccagatgac ccagtctcca     2040

tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc aagtcagagc     2100

attagcagct atttaaattg gtatcagcag aaaccaggga aagcccctaa gctcctgatc     2160

tatgctgcat ccagtttgca aagtggggtc ccatcaaggt tcagtggcag tggatctggg     2220

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     2280

caacagagtt acagtacccc tctcactttc ggcggcggaa caaaggtgga gatcaagcgg     2340

accgtggccg ctcccagcgt gttcatcttc ccccccagcg acgagcagct taagagcggt     2400

accgctagcg tggtgtgcct gctgaacaac ttctaccccc gggaggccaa ggtgcagtgg     2460

aaggtggaca acgccctgca gagcggcaac agccaggaaa gcgtcaccga gcaggacagc     2520

aaggactcca cctacagcct gagcagcacc ctgaccctga gcaaggccga ctacgagaag     2580

cacaaggtgt acgcctgcga agtgacccac cagggcctgt ccagccccgt gaccaagagc     2640

ttcaaccggg gcgagtgcta atctagaggg cccgtttaaa cccgctgatc agcctcgact     2700

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     2760

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     2820

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     2880

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga     2940

accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg     3000

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     3060

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     3120

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     3180

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     3240

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     3300

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     3360

aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt     3420

tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc acgcgcatgc     3480

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg     3540

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc     3600

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc     3660

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc     3720

ttcttgacga gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc     3780

caacctgcca tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg     3840

aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt     3900

cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     3960

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     4020

catcaatgta tcttatcatg tctgtatacc gtcgattcga gttaattaac tggcctcatg     4080

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca     4140

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct     4200

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc     4260

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     4320

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     4380

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     4440

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     4500

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     4560

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     4620

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     4680

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     4740

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     4800

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     4860

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     4920

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     4980

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     5040

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     5100

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     5160

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     5220

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     5280

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     5340

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     5400

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     5460

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     5520

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     5580

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     5640

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     5700

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     5760

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     5820

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     5880

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     5940

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     6000

caaatagggg ttccgcgcac atttccccga aaagtgccac ctaaattgta agcgttaata     6060

ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg     6120

aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg agtggccgct     6180

acagggcgct cccattcgcc attcaggctg cgcaactgtt gggaagggcg tttcggtgcg     6240

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg     6300

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg agcgcgacgt     6360

aatacgactc actatagggc gaattggcgg aaggccgtca aggcctaggc gcgcctgaat     6420

aacttcgtat agcatacatt atagcaattt atcgaaaaag cctgaactca ccgcgacatc     6480

cgtggagaaa ttcctcatcg aaaaattcga ctccgtgtcc gatctcatgc agctgtccga     6540

gggcgaggag agtagagcat tctcattcga tgtgggcggg agaggctacg tgctgagagt     6600

gaactcttgt gccgacggct tctacaagga ccgatacgtc taccggcatt ttgcttccgc     6660

cgctctgcct attccagaag tcctggacat tggggagttt agcgagtccc tcacttactg     6720

tattagccgg cgagcccagg gagtgacact ccaggatctg cctgaaactg aactgcctgc     6780

tgtgctccag cctgtcgctg aggcaatgga tgctattgct gctgccgatc tgagtcagac     6840

tagcggattc ggcccatttg gaccccaggg cattggccag tacacaacat ggcgagactt     6900

catctgtgct atcgccgatc ctcacgtgta ccattggcag actgtgatgg acgatactgt     6960

gtctgcttct gtggcacagg cactcgacga actcatgctg tgggctgagg actgtcctga     7020

agtgagacat ctggtccatg ccgattttgg ctccaacaat gtgctcaccg ataacgggag     7080

aatcactgcc gtgatcgact ggagcgaggc aatgtttggc gattcccagt acgaagtggc     7140

caacatcttc ttttggcggc cttggctggc ttgtatggaa cagcagaccc ggtactttga     7200

acggcgccac cctgagctgg ctgggagtcc tagactgaga gcctacatgc tccgaattgg     7260

cctggatcag ctctaccagt cactggtgga tggcaatttc gacgatgctg cttgggcaca     7320

ggggcgctgt gatgctattg tccgatccgg cgctggaact gtggggagaa cacagatcgc     7380

taggagatcc gctgctgtct ggaccgatgg atgtgtggaa gtgctggccg atagtggaaa     7440

ccggaggcct tcaacccgac cccgggcaaa ggagtaatga ccgtttaaac ccgctgatca     7500

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     7560

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     7620

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     7680

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggggatcccg     7740

cgttgacatt gattattgac tagcctcgga ttctcgaggc taggctagtg agacgatacg     7800

tctcatcgac gatccggggg ccgccgggaa ctgccgctgg ccccccaccg ccccaaggat     7860

ctcccggtcc ccgcccggcg tgctgacgtc acggcgctgc cccagggtgt gctgggcagg     7920

tcgcggggag cgctgggaaa tggagtccat tagcagaagt ggcccttggc cacttccagg     7980

agtcgctgtg ccccgatgca cactgggaag tccgcagctc cgaggcgccc agtggaaatc     8040

gccagatgag ggcctcctcc ggggaatgct gggaaatgga gtctacaggc cggaggggtg     8100

ccccacggca tactaggaag tgtgtagcac cgggtaaagg ggatgaatag cagactgccc     8160

cggggcagtt aggagatccg ggggccgccg ggaactgccg ctggcccccc accgccccaa     8220

ggatctcccg gtccccgccc ggcgtgctga cgtcacggcg ctgccccagg gtgtgctggg     8280

caggtcgcgg ggagcgctgg gaaatggagt ccattagcag aagtggccct tggccacttc     8340

caggagtcgc tgtgccccga tgcacactgg gaagtccgca gctccgaggc gcccagtgga     8400

aatcgccaga tgagggcctc ctccggggaa tgctgggaaa tggagtctac aggccggagg     8460

ggtgccccac ggcatactag gaagtgtgta gcaccgggta aaggggatga atag           8514


<210>  6
<211>  7593
<212>  DNA
<213>  Artificial sequence

<220>
<223>  vector comprising V503 expression cassette containing coding 
       sequence for CRE recombinase

<400>  6
gacggatcgg gagatctcgt tgacattgat tattgactag ttattaatag taatcaatta       60

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg      120

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc      180

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa      240

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca      300

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta      360

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt      420

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg      480

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca      540

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca      600

gagctctctg gctaactaga gaacccactg cttactggct tatcgaaatt aatacgactc      660

actataggga gacccaagct ggctagcgtt taaacttaag cttggtaccg agctcggatc      720

cgccgccacc atgggcagca acaacgccct ccagaccatc atcaacgccc gcctgcccgg      780

cgaagagggc ctgtggcaga tccatctcca ggacggcaag atcagcgcca tcgacgccca      840

gagcggcgtg atgcccatca ccgagaacag cctggacgcc gagcagggcc tggtgatccc      900

ccccttcgtg gaaccccaca tccacctgga caccacccag acagccggcc agcccaactg      960

gaaccagtcc ggcaccctgt tcgagggcat cgagagatgg gccgagcgga aggccctgct     1020

gacccacgac gacgtgaagc agcgggcctg gcagaccctg aagtggcaga tcgccaacgg     1080

catccagcac gtgcggacac acgtggacgt gtccgatgcc accctgaccg ccctgaaggc     1140

catgctggaa gtgaagcagg aagtggcccc ctggatcgac ctccagatcg tggccttccc     1200

acaggaaggc atcctgagct accccaacgg cgaagccctg ctggaagagg ccctgagact     1260

gggcgccgac gtggtcggag ccatccccca cttcgagttc acccgcgagt acggcgtgga     1320

aagcctgcac aagaccttcg ccctggccca gaagtacgac cggctgatcg atgtgcattg     1380

cgacgagatc gacgacgagc agagcagatt cgtggaaacc gtggccgccc tggctcacca     1440

cgagggaatg ggagccagag tgaccgccag ccacaccacc gccatgcaca gctacaacgg     1500

cgcctacacc tcccggctgt tccggctgct gaagatgagc ggcatcaact tcgtggccaa     1560

ccccctggtg aacatccatc tgcaaggcag attcgacacc taccccaagc ggagaggcat     1620

caccagagtg aaagagatgc tggaatccgg catcaacgtg tgcttcggcc acgacgatgt     1680

gttcgacccc tggtatcccc tgggcaccgc caacatgctc caggtgctgc acatgggcct     1740

gcacgtgtgc cagctgatgg gctacggcca gatcaacgac ggcctgaacc tgatcaccca     1800

ccacagcgcc cggaccctga acctgcaaga ctacggcatt gccgccggaa acagcgccaa     1860

cctgatcatc ctgcccgccg agaacggctt cgacgccctg cggagacagg tgccagtgcg     1920

gtatagcgtg cggggaggca aagtgatcgc ctccacccag cccgcccaga ccaccgtgta     1980

cctggaacag cccgaggcca tcgactacaa gagatgagcg gccctagagg gcccgtttaa     2040

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     2100

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     2160

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     2220

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     2280

atggacgcgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt     2340

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     2400

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     2460

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt     2520

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     2580

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     2640

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2700

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2760

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2820

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctctctg     2880

gctaactaga gaacccactg cttactggct tatcgaaatt aatacgactc actataggga     2940

gacccaagct ggctagcgtt taaacttaag cttgctgtga aatgtccaat ttactgaccg     3000

tacaccaaaa tttgcctgca ttaccggtcg atgcaacgag tgatgaggtt cgcaagaacc     3060

tgatggacat gttcagggat cgccaggcgt tttctgagca tacctggaaa atgcttctgt     3120

ccgtttgccg gtcgtgggcg gcatggtgca agttgaataa ccggaaatgg tttcccgcag     3180

aacctgaaga tgttcgcgat tatcttctat atcttcaggc gcgcggtctg gcagtaaaaa     3240

ctatccagca acatttgggc cagctaaaca tgcttcatcg tcggtccggg ctgccacgac     3300

caagtgacag caatgctgtt tcactggtta tgcggcggat ccgaaaagaa aacgttgatg     3360

ccggtgaacg tgcaaaacag gctctagcgt tcgaacgcac tgatttcgac caggttcgtt     3420

cactcatgga aaatagcgat cgctgccagg atatacgtaa tctggcattt ctggggattg     3480

cttataacac cctgttacgt atagccgaaa ttgccaggat cagggttaaa gatatctcac     3540

gtactgacgg tgggagaatg ttaatccata ttggcagaac gaaaacgctg gttagcaccg     3600

caggtgtaga gaaggcactt agcctggggg taactaaact ggtcgagcga tggatttccg     3660

tctctggtgt agctgatgat ccgaataact acctgttttg ccgggtcaga aaaaatggtg     3720

ttgccgcgcc atctgccacc agccagctat caactcgcgc cctggaaggg atttttgaag     3780

caactcatcg attgatttac ggcgctaagg atgactctgg tcagagatac ctggcctggt     3840

ctggacacag tgcccgtgtc ggagccgcgc gagatatggc ccgcgctgga gtttcaatac     3900

cggagatcat gcaagctggt ggctggacca atgtaaatat tgtcatgaac tatatccgta     3960

acctggatag tgaaacaggg gcaatggtgc gcctgctgga agatggcgat tagccatcta     4020

gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     4080

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4140

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4200

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     4260

atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct agggggtatc     4320

cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     4380

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     4440

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     4500

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     4560

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     4620

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     4680

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     4740

ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt ccccaggctc     4800

cccagcaggc agaagtatgc aaagcacgcg catgcccgac ggcgaggatc tcgtcgtgac     4860

ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat     4920

cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga     4980

tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc     5040

cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgagcggg     5100

actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg agatttcgat     5160

tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg     5220

atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccaa cttgtttatt     5280

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     5340

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgt     5400

ataccgtcga cctctagcta gagcttggcg taatcatggt catagctgtt tcctgtgtga     5460

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     5520

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     5580

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     5640

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     5700

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     5760

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     5820

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     5880

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     5940

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     6000

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     6060

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     6120

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     6180

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     6240

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     6300

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     6360

accaccgctg gtagcggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     6420

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     6480

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     6540

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     6600

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     6660

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     6720

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     6780

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     6840

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     6900

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     6960

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     7020

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     7080

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     7140

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     7200

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     7260

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     7320

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     7380

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     7440

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     7500

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     7560

cgcacatttc cccgaaaagt gccacctgac gtc                                  7593


<210>  7
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  misc_feature
<223>  Exendin-4

<400>  7

His Gly Glu Gly Arg Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  GLP-1

<400>  8

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  9
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  GLP-2

<400>  9

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Arg 
        


<210>  10
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Glucagon

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Arg Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PACAP-38

<400>  11

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  12
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  parathyroid hormone

<400>  12

Met Ile Pro Ala Lys Asp Met Ala Lys Val Met Ile Val Met Leu Ala 
1               5                   10                  15      


Ile Cys Phe Leu Thr Lys Ser Asp Gly Lys Ser Val Lys Lys Arg Ser 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
        35                  40                  45              


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
    50                  55                  60                  


Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser Gln 
65                  70                  75                  80  


Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu Lys 
                85                  90                  95      


Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys Ala 
            100                 105                 110         


Lys Ser Gln 
        115 


<210>  13
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  13
atacagacct ta                                                           12


<210>  14
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  14
ctacagactg ga                                                           12


<210>  15
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  15
ctccagggct ga                                                           12


<210>  16
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  16
gtacagacca at                                                           12


<210>  17
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  17
gtagtactcc actgtctggc tgt                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  18
ttgcaaccac atcctgagtg tgt                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  19
acggagataa aggaggaagc agg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSS spacer

<400>  20
gccgggcccc gcggcccggc ggc                                               23


<210>  21
<211>  5986
<212>  DNA
<213>  Artificial sequence

<220>
<223>  vector V525 expressing GLP1 receptor

<400>  21
aacaaaatat taacgcttac aatttccatt cgccattcag gctgcgcaac tgttgggaag       60

ggcgatcggt gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa      120

ggcgattaag ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca      180

gtgccaagct gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt      240

atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata      300

tgtacattta tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta      360

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg      420

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      480

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      540

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      600

gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      660

tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      720

tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat      780

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      840

actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac      900

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagaatttt gtaatacgac      960

tcactatagg gcggccgcga attcgccctt gatggcccag tcctgaactc cccgccatgg     1020

ccggcgcccc cggcccgctg cgccttgcgc tgctgctgct cgggatggtg ggcagggccg     1080

gcccccgccc ccagggtgcc actgtgtccc tctgggagac ggtgcagaaa tggcgagaat     1140

accgacgcca gtgccagcgc tccctgactg aggatccacc tcctgccaca gacttgttct     1200

gcaaccggac cttcgatgaa tacgcctgct ggccagatgg ggagccaggc tcgttcgtga     1260

atgtcagctg cccctggtac ctgccctggg ccagcagtgt gccgcagggc cacgtgtacc     1320

ggttctgcac agctgaaggc ctctggctgc agaaggacaa ctccagcctg ccctggaggg     1380

acttgtcgga gtgcgaggag tccaagcgag gggagagaag ctccccggag gagcagctcc     1440

tgttcctcta catcatctac acggtgggct acgcactctc cttctctgct ctggttatcg     1500

cctctgcgat cctcctcggc ttcagacacc tgcactgcac caggaactac atccacctga     1560

acctgtttgc atccttcatc ctgcgagcat tgtccgtctt catcaaggac gcagccctga     1620

agtggatgta tagcacagcc gcccagcagc accagtggga tgggctcctc tcctaccagg     1680

actctctgag ctgccgcctg gtgtttctgc tcatgcagta ctgtgtggcg gccaattact     1740

actggctctt ggtggagggc gtgtacctgt acacactgct ggccttctcg gtcttctctg     1800

agcaatggat cttcaggctc tacgtgagca taggctgggg tgttcccctg ctgtttgttg     1860

tcccctgggg cattgtcaag tacctctatg aggacgaggg ctgctggacc aggaactcca     1920

acatgaacta ctggctcatt atccggctgc ccattctctt tggcattggg gtgaacttcc     1980

tcatctttgt tcgggtcatc tgcatcgtgg tatccaaact gaaggccaat ctcatgtgca     2040

agacagacat caaatgcaga cttgccaagt ccacgctgac actcatcccc ctgctgggga     2100

ctcatgaggt catctttgcc tttgtgatgg acgagcacgc ccgggggacc ctgcgcttca     2160

tcaagctgtt tacagagctc tccttcacct ccttccaggg gctgatggtg gccatattat     2220

actgctttgt caacaatgag gtccagctgg aatttcggaa gagctgggag cgctggcggc     2280

ttgagcactt gcacatccag agggacagca gcatgaagcc cctcaagtgt cccaccagca     2340

gcctgagcag tggagccacg gcgggcagca gcatgtacac agccacttgc caggcctcct     2400

gcagctgaga ctccagcgcc tgccctccct ggggtccttg ctgcaggcct ggtggccaat     2460

ccaggtggga gagacactca agggcgaatt cagatctggt accgatatca agcttgtcga     2520

ctctagattg cggccgcggt catagctgtt tcctgaacag atcccgggtg gcatccctgt     2580

gacccctccc cagtgcctct cctggccctg gaagttgcca ctccagtgcc caccagcctt     2640

gtcctaataa aattaagttg catcattttg tctgactagg tgtccttcta taatattatg     2700

gggtggaggg gggtggtatg gagcaagggg caagttggga agacaacctg tagggcctgc     2760

ggggtctatt gggaaccaag ctggagtgca gtggcacaat cttggctcac tgcaatctcc     2820

gcctcctggg ttcaagcgat tctcctgcct cagcctcccg agttgttggg attccaggca     2880

tgcatgacca ggctcagcta atttttgttt ttttggtaga gacggggttt caccatattg     2940

gccaggctgg tctccaactc ctaatctcag gtgatctacc caccttggcc tcccaaattg     3000

ctgggattac aggcgtgaac cactgctccc ttccctgtcc ttctgatttt aaaataacta     3060

taccagcagg aggacgtcca gacacagcat aggctacctg gccatgccca accggtggga     3120

catttgagtt gcttgcttgg cactgtcctc tcatgcgttg ggtccactca gtagatgcct     3180

gttgaattgg gtacgcggcc agcttggctg tggaatgtgt gtcagttagg gtgtggaaag     3240

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     3300

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     3360

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     3420

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     3480

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     3540

tgcaaaaagc tcctcgactg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     3600

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     3660

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     3720

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     3780

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     3840

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     3900

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     3960

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt     4020

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     4080

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     4140

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     4200

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc     4260

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     4320

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     4380

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     4440

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     4500

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     4560

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     4620

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     4680

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     4740

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     4800

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     4860

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     4920

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     4980

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     5040

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     5100

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     5160

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     5220

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     5280

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     5340

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     5400

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc     5460

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     5520

catttccccg aaaagtgcca cctgacgcgc cctgtagcgg cgcattaagc gcggcgggtg     5580

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     5640

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     5700

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     5760

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     5820

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     5880

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     5940

atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatatt                    5986


<210>  22
<211>  6723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  vector E518 with cAMP response element and minimal promoter 
       driving CD19

<400>  22
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgtaataaaa      240

tatctttatt ttcattacat ctgtgtgttg gttttttgtg tgaatcgata gtactaacat      300

acgctctcca tcaaaacaaa acgaaacaaa acaaactagc aaaataggct gtccccagtg      360

caagtgcagg tgccagaaca tttctctggc ctaactggcc ggtacctgag ctcgctagcg      420

caccagacag tgacgtcagc tgccagatcc catggccgtc atactgtgac gtctttcaga      480

caccccattg acgtcaatgg gagaacagat ctggcctcgg cggccaagct tagacactag      540

agggtatata atggaagctc gacttccagc ttggcaatcc ggtactacta gcgccgccac      600

catgccacct cctcgcctcc tcttcttcct cctcttcctc acccccatgg aagtcaggcc      660

cgaggaacct ctagtggtga aggtggaaga gggagataac gctgtgctgc agtgcctcaa      720

ggggacctca gatggcccca ctcagcagct gacctggtct cgggagtccc cgcttaaacc      780

cttcttaaaa ctcagcctgg ggctgccagg cctgggaatc cacatgaggc ccctggccat      840

ctggcttttc atcttcaacg tctctcaaca gatggggggc ttctacctgt gccagccggg      900

gcccccctct gagaaggcct ggcagcctgg ctggacagtc aatgtggagg gcagcgggga      960

gctgttccgg tggaatgttt cggacctagg tggcctgggc tgtggcctga agaacaggtc     1020

ctcagagggc cccagctccc cttccgggaa gctcatgagc cccaagctgt atgtgtgggc     1080

caaagaccgc cctgagatct gggagggaga gcctccgtgt ctcccaccga gggacagcct     1140

gaaccagagc ctcagccagg acctcaccat ggcccctggc tccacactct ggctgtcctg     1200

tggggtaccc cctgactctg tgtccagggg ccccctctcc tggacccatg tgcaccccaa     1260

ggggcctaag tcattgctga gcctagagct gaaggacgat cgcccggcca gagatatgtg     1320

ggtaatggag acgggtctgt tgttgccccg ggccacagct caagacgctg gaaagtatta     1380

ttgtcaccgt ggcaacctga ccatgtcatt ccacctggag atcactgctc ggccagtact     1440

atggcactgg ctgctgagga ctggtggctg gaaggtctca gctgtgactt tggcttatct     1500

gatcttctgc ctgtgttccc ttgtgggcat tcttcatctt caaagagccc tggtcctgag     1560

gaggaaaaga aagcgaatga ctgaccccac caggagattc ttcaaagtga cgcctccccc     1620

aggaagcggg ccccagaacc agtacgggaa cgtgctgtct ctccccacac ccacctcagg     1680

cctcggacgc gcccagcgtt gggccgcagg cctggggggc actgccccgt cttatggaaa     1740

cccgagcagc gacgtccagg cggatggagc cttggggtcc cggagcccgc cgggagtggg     1800

cccagaagaa gaggaagggg agggctatga ggaacctgac agtgaggagg actccgagtt     1860

ctatgagaac gactccaacc ttgggcagga ccagctctcc caggatggca gcggctacga     1920

gaaccctgag gatgagcccc tgggtcctga ggatgaagac tccttctcca acgctgagtc     1980

ttatgagaac gaggatgaag agctgaccca gccggtcgcc aggacaatgg acttcctgag     2040

ccctcatggg tcagcctggg accccagccg ggaagcaacc tccctggggt cccagtccta     2100

tgaggatatg agaggaatcc tgtatgcagc cccccagctc cgctccattc ggggccagcc     2160

tggacccaat catgaggaag atgcagactc ttatgagaac atggataatc ccgatgggcc     2220

agacccagcc tggggaggag ggggccgcat gggcacctgg agcaccaggt gagcggccgc     2280

tcgagtctag agggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc     2340

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     2400

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     2460

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     2520

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta     2580

gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     2640

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     2700

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     2760

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt     2820

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     2880

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt     2940

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     3000

aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc     3060

cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccag     3120

gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta     3180

gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc     3240

cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc     3300

ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg     3360

caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga caggatgagg     3420

atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga     3480

gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt     3540

ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct     3600

gaatgaactg caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg     3660

cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt     3720

gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc     3780

tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc     3840

gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga     3900

tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg     3960

catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat     4020

ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg     4080

ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc     4140

tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta     4200

tcgccttctt gacgagttct tctgagcggg actctggggt tcgaaatgac cgaccaagcg     4260

acgcccaacc tgccatcacg agatttcgat tccaccgccg ccttctatga aaggttgggc     4320

ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg     4380

gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat     4440

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     4500

aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg     4560

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     4620

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     4680

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     4740

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     4800

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     4860

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     4920

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     4980

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     5040

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     5100

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     5160

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     5220

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     5280

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     5340

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     5400

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     5460

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggttt ttttgtttgc     5520

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     5580

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     5640

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     5700

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     5760

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg     5820

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca     5880

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt     5940

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt     6000

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca     6060

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca     6120

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga     6180

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact     6240

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga     6300

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg     6360

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc     6420

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga     6480

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat     6540

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt     6600

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     6660

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     6720

gtc                                                                   6723


<210>  23
<211>  475
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V105 (VH sequence through the end of the JH)

<400>  23
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggcat      300

ggcgagggca ccttcacctc cgacctgtcc aaacaaatgg aagaagaagc cgtccggctg      360

ttcatcgaat ggctgaaaaa tggcggccct tcctctggcg cccctcctcc ttcttcgctg      420

caggatgatg cttttgatat ctggggccaa gggacaatgg tcaccgtgtc ctcag           475


<210>  24
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V105 (VH sequence through the end of the JH)

<400>  24

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln 
            100                 105                 110         


Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
        115                 120                 125             


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Ser Leu Gln Asp Asp Ala 
    130                 135                 140                 


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155             


<210>  25
<211>  472
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V107 (VH sequence through the end of the JH)

<400>  25
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcct ctggcgcccc tcctccttct      420

gtggctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc ag              472


<210>  26
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V107 (VH sequence through the end of the JH)

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala Phe 
    130                 135                 140                 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155         


<210>  27
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  27
gagagtttgg atcccaactt tcttgtccac cttggtgttg c                           41


<210>  28
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  28
gagagatttg gtctctatgt cgatctgatc aagagacagg ataaggagcc                  50


<210>  29
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  29
gagagagatt ggtctcgcct gagttccacg acaccgtcac c                           41


<210>  30
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  30
ctacgaggtc tcactgtgnn kcatggcgag ggcaccttca cctccgacct gtccaaac         58


<210>  31
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  31
ttaagaggta ccctcgagca gacatgataa gatacattga tgagtttgga caaac            55


<210>  32
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V105 exendin junction

<400>  32

Cys Ala Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln 
1               5                   10                  15      


Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25                  30          


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Ser Leu Gln Asp Asp Ala 
        35                  40                  45              


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    50                  55                  60          


<210>  33
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V107 exendin junction

<400>  33

Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala 
        35                  40                  45              


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    50                  55                  60          


<210>  34
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Oxyntomodulin

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  35
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence encoding glucagon

<400>  35
cattcacagg gcacattcac cagtgactac agcaagtatc tggactccag gcgtgcccaa       60

gattttgtgc agtggttgat gaatacc                                           87


<210>  36
<211>  111
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence encoding oxyntomodulin

<400>  36
cattcacagg gcacattcac cagtgactac agcaagtatc tggactccag gcgtgcccaa       60

gattttgtgc agtggttgat gaataccaag aggaacagga ataacattgc c               111


<210>  37
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V36 glucagon junction

<400>  37

Cys Thr Thr Asp Leu Ser Arg Arg Arg His Ser Gln Gly Thr Phe Thr 
1               5                   10                  15      


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
            20                  25                  30          


Gln Trp Leu Met Asn Thr Leu Pro Met Pro 
        35                  40          


<210>  38
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V66 glucagon junction

<400>  38

Cys Thr Thr Asp Pro Val Leu Lys His Ser Gln Gly Thr Phe Thr Ser 
1               5                   10                  15      


Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln 
            20                  25                  30          


Trp Leu Met Asn Thr Leu Ala Pro Val 
        35                  40      


<210>  39
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V69 glucagon junction

<400>  39

Cys Ala Arg Ala Glu Ser Ala Gly Arg His Ser Gln Gly Thr Phe Thr 
1               5                   10                  15      


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
            20                  25                  30          


Gln Trp Leu Met Asn Thr Thr Ser Met Val Arg 
        35                  40              


<210>  40
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V23 oxyntomodulin junction

<400>  40

Cys Ala Ser Asn Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser 
1               5                   10                  15      


Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met 
            20                  25                  30          


Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala Met Leu Leu 
        35                  40                  45  


<210>  41
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V74 oxyntomodulin junction

<400>  41

Cys Ala Arg Asp Lys Gly Ile Lys His Ser Gln Gly Thr Phe Thr Ser 
1               5                   10                  15      


Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln 
            20                  25                  30          


Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala Ser Lys Gln 
        35                  40                  45              


Val Arg 
    50  


<210>  42
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V100 oxyntomodulin junction

<400>  42

Cys Ala Arg Asp Leu Ser Asp Leu Ser His Ser Val Leu Leu Arg His 
1               5                   10                  15      


Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg 
            20                  25                  30          


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg 
        35                  40                  45              


Asn Asn Ile Ala Arg Pro Leu Val Leu Ser 
    50                  55              


<210>  43
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Vasoactive intestinal peptide

<400>  43

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  44
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PACAP-27

<400>  44

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  45
<211>  35
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  misc_feature
<223>  helodermin

<400>  45

His Ser Asp Ala Ile Phe Thr Glu Glu Tyr Ser Lys Leu Leu Ala Lys 
1               5                   10                  15      


Leu Ala Leu Gln Lys Tyr Leu Ala Ser Ile Leu Gly Ser Arg Thr Ser 
            20                  25                  30          


Pro Pro Pro 
        35  


<210>  46
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Peptide histidine methionine

<400>  46

His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met 
            20                  25          


<210>  47
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  secretin

<400>  47

His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210>  48
<211>  44
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Growth hormone releasing factor

<400>  48

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly 
            20                  25                  30          


Glu Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu 
        35                  40                  


<210>  49
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Gastric inhibitory peptide

<400>  49

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  50
<211>  1224
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V125

<400>  50
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggaaagcgg cggaggcctg gtgcagcccg gtcgaagcct gagactgagc      120

tgcgccgcca gcggcttcac ctttgacgac tacgccatgc actgggtccg ccaggcccct      180

ggcaagggac tggaatgggt gtccggcatc agctggaaca gcggcagcat cggctacgcc      240

gacagcgtga agggccggtt caccatcagc cgggacaacg ccaagaacag cctgtacctg      300

cagatgaaca gcctgcgggc cgaggacacc gccttgtatt actgtgcgag agatgagcgg      360

catggcgagg gcaccttcac ctccgacctg tccaaacaaa tggaagaaga agccgtccgg      420

ctgttcatcg aatggctgaa aaatggcggc ccttcctctg gcgcccctcc tccttctgtg      480

gctgcttttg atatctgggg ccaagggaca atggtcaccg tgtcctcaga gcccaaatct      540

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      600

gtcttcctct tccccccaaa acccaaggac accctcatga tctctagaac ccctgaggtc      660

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      720

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      780

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      840

aagtgcaagg tgtccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      900

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      960

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1020

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1080

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1140

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1200

agcctctccc tgtctccggg caaa                                            1224


<210>  51
<211>  408
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V125

<400>  51

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser 
        115                 120                 125             


Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
    130                 135                 140                 


Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val 
145                 150                 155                 160 


Ala Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                165                 170                 175     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            180                 185                 190         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        195                 200                 205             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    210                 215                 220                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
225                 230                 235                 240 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                245                 250                 255     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            260                 265                 270         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        275                 280                 285             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    290                 295                 300                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
305                 310                 315                 320 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                325                 330                 335     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            340                 345                 350         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        355                 360                 365             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    370                 375                 380                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
385                 390                 395                 400 


Ser Leu Ser Leu Ser Pro Gly Lys 
                405             


<210>  52
<211>  4917
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V248

<400>  52
tcgagttaat taactggcct catgggcctt ccgctcactg cccgctttcc agtcgggaaa       60

cctgtcgtgc cagctgcatt aacatggtca tagctgtttc cttgcgtatt gggcgctctc      120

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg gtaaagcctg gggtgcctaa      180

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc      240

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga      300

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct      360

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg      420

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag      480

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat      540

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac      600

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac      660

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc      720

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt      780

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc      840

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg      900

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca      960

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     1020

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     1080

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagaa     1140

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     1200

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     1260

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     1320

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     1380

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     1440

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     1500

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     1560

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     1620

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     1680

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     1740

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     1800

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     1860

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     1920

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     1980

ccacctaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca     2040

gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca aaagaataga     2100

ccgagatagg gttgagtggc cgctacaggg cgctcccatt cgccattcag gctgcgcaac     2160

tgttgggaag ggcgtttcgg tgcgggcctc ttcgctatta cgccagctgg cgaaaggggg     2220

atgtgctgca aggcgattaa gttgggtaac gccagggttt tcccagtcac gacgttgtaa     2280

aacgacggcc agtgagcgcg acgtaatacg actcactata gggcgaattg gcggaaggcc     2340

gtcaaggcct acgcgccgac cgagtccact agttattaat agtaatcaat tacggggtca     2400

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct     2460

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta     2520

acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac     2580

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt     2640

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag     2700

tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat     2760

gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat     2820

gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc     2880

ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctctc     2940

tggctaacta gagaacccac tgcttactgc tcgacgatct gatcaagaga caggataagg     3000

agccgccacc atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt     3060

ccagtgtgaa gtgcagctgg tggaaagcgg cggaggcctg gtgcagcccg gtcgaagcct     3120

gagactgagc tgcgccgcca gcggcttcac ctttgacgac tacgccatgc actgggtccg     3180

ccaggcccct ggcaagggac tggaatgggt gtccggcatc agctggaaca gcggcagcat     3240

cggctacgcc gacagcgtga agggccggtt caccatcagc cgggacaacg ccaagaacag     3300

cctgtacctg cagatgaaca gcctgcgggc cgaggacacc gccttgtatt actgtagcag     3360

aaagaagcgg catggcgagg gcaccttcac ctccgacctg tccaaacaaa tggaagaaga     3420

agccgtccgg ctgttcatcg aatggctgaa aaatggcggc ccttcctctg gcgcccctcc     3480

tccttctgtg gctgcttttg atatctgggg ccaagggaca atggtcaccg tgtcctcaga     3540

gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg     3600

gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctctagaac     3660

ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa     3720

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     3780

caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg     3840

caaggagtac aagtgcaagg tgtccaacaa agccctccca gcccccatcg agaaaaccat     3900

ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     3960

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga     4020

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     4080

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag     4140

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     4200

cacgcagaag agcctctccc tgtctccggg caaatctggc gaagtgcagc tggtggaaag     4260

cggcggaggc ctggtgcagc ccggtcgaag cctgagactg agctgcgccg ccagcggctt     4320

cacctttgac gactacgcca tgcactgggt ccgccaggcc cctggcaagg gactggaatg     4380

ggtgtccggc atcagctgga acagcggcag catcggctac gccgacagcg tgaagggccg     4440

gttcaccatc agccgggaca acgccaagaa cagcctgtac ctgcagatga acagcctgcg     4500

ggccgaggac accgccttgt attactgtag cagaaagaag cggcatggcg agggcacctt     4560

cacctccgac ctgtccaaac aaatggaaga agaagccgtc cggctgttca tcgaatggct     4620

gaaaaatggc ggcccttcct ctggcgcccc tcctccttct gtggctgctt ttgatatctg     4680

gggccaaggg acaatggtca ccgtgtcctc ataggttttc cgggacgccg gctggatgat     4740

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     4800

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     4860

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgacc        4917


<210>  53
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V126 (from VH to the end of JH)

<400>  53
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gaaggatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcct ctggcgcccc tcctccttct      420

gtggctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc a               471


<210>  54
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V126 (from VH to the end of JH)

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala Phe 
    130                 135                 140                 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155         


<210>  55
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V127 (from VH to the end of JH)

<400>  55
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagataga      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcct ctggcgcccc tcctccttct      420

gtggctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc a               471


<210>  56
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V127 (from VH to the end of JH)

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala Phe 
    130                 135                 140                 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155         


<210>  57
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V128 (from VH to the end of JH)

<400>  57
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagatgag      300

aagcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcct ctggcgcccc tcctccttct      420

gtggctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc a               471


<210>  58
<211>  157
<212>  PRT
<213>  artificial sequence

<220>
<223>  ITS007-V128 (from VH to the end of JH)

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Lys His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala Phe 
    130                 135                 140                 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155         


<210>  59
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V130 (from VH to the end of JH)

<400>  59
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtag cagaaagaag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcct ctggcgcccc tcctccttct      420

gtggctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc a               471


<210>  60
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V130 (from VH to the end of JH)

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala Phe 
    130                 135                 140                 


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155         


<210>  61
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V206 (from VH to the end of JH)

<400>  61
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcgg aggcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  62
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V206 (from VH to the end of JH)

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  63
<211>  480
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V209 (from VH to the end of JH)

<400>  63
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg cggagtcctc tggcgcccct      420

cctccttctg tggctgcttt tgatatctgg ggccaaggga caatggtcac cgtgtcctca      480


<210>  64
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V209 (from VH to the end of JH)

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
    130                 135                 140                 


Ala Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 160 


<210>  65
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V211 (from VH to the end of JH)

<400>  65
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gagagatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg agtcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  66
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V211 (from VH to the end of JH)

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  67
<211>  474
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V212 (from VH to the end of JH)

<400>  67
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gaaggatgag      300

tggcggcatg gcgagggcac cttcacctcc gacctgtcca aacaaatgga agaagaagcc      360

gtccggctgt tcatcgaatg gctgaaaaat ggcggccctt cctctggcgc ccctcctcct      420

tctgtggctg cttttgatat ctggggccaa gggacaatgg tcaccgtgtc ctca            474


<210>  68
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V212 (from VH to the end of JH)

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Trp Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
            100                 105                 110         


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
        115                 120                 125             


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala Ala 
    130                 135                 140                 


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155             


<210>  69
<211>  592
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V152 (tet) tetracycline inducible CMV promoter

<400>  69
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtcc      540

ctatcagtga tagagatcta tataagtccc tatcagtgat agagagagct ct              592


<210>  70
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V241 (from VH to the end of JH)

<400>  70
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gaaggatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcgg aggcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  71
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V241 (from VH to the end of JH)

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  72
<211>  480
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V242 (from VH to the end of JH)

<400>  72
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gaaggatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg cggagtcctc tggcgcccct      420

cctccttctg tggctgcttt tgatatctgg ggccaaggga caatggtcac cgtgtcctca      480


<210>  73
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V242 (from VH to the end of JH)

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
    130                 135                 140                 


Ala Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 160 


<210>  74
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V243 (from VH to the end of JH)

<400>  74
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc gaaggatgag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg agtcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  75
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V243 (from VH to the end of JH)

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  76
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V244 (from VH to the end of JH)

<400>  76
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtag cagaaagaag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttcgg aggcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  77
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V244 (from VH to the end of JH)

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  78
<211>  480
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V245 (from VH to the end of JH)

<400>  78
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtag cagaaagaag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg cggagtcctc tggcgcccct      420

cctccttctg tggctgcttt tgatatctgg ggccaaggga caatggtcac cgtgtcctca      480


<210>  79
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V245 (from VH to the end of JH)

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
    130                 135                 140                 


Ala Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 160 


<210>  80
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS007-V246 (from VH to the end of JH)

<400>  80
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtag cagaaagaag      300

cggcatggcg agggcacctt cacctccgac ctgtccaaac aaatggaaga agaagccgtc      360

cggctgttca tcgaatggct gaaaaatggc ggcccttccg agtcctctgg cgcccctcct      420

ccttctgtgg ctgcttttga tatctggggc caagggacaa tggtcaccgt gtcctca         477


<210>  81
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V246 (from VH to the end of JH)

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
            100                 105                 110         


Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
        115                 120                 125             


Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
    130                 135                 140                 


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155                 


<210>  82
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V125 exendin junction

<400>  82

Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45          


<210>  83
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V126 exendin junction

<400>  83

Cys Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45          


<210>  84
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V127 exendin junction

<400>  84

Cys Ala Arg Asp Arg Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45          


<210>  85
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V128 exendin junction

<400>  85

Cys Ala Arg Asp Glu Lys His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45          


<210>  86
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V130 exendin junction

<400>  86

Cys Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45          


<210>  87
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V212 exendin junction

<400>  87

Cys Ala Lys Asp Glu Trp Arg His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp 
            20                  25                  30          


Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val Ala 
        35                  40                  45              


<210>  88
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V206 exendin junction

<400>  88

Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  89
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V209 exendin junction

<400>  89

Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40                  45              


Val Ala 
    50  


<210>  90
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V211 exendin junction

<400>  90

Cys Ala Arg Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  91
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V241 exendin junction

<400>  91

Cys Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  92
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V242 exendin junction

<400>  92

Cys Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40                  45              


Val Ala 
    50  


<210>  93
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V243 exendin junction

<400>  93

Cys Ala Lys Asp Glu Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  94
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V244 exendin junction

<400>  94

Cys Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ala Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  95
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V245 exendin junction

<400>  95

Cys Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ala Glu Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40                  45              


Val Ala 
    50  


<210>  96
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS007-V246 exendin junction

<400>  96

Cys Ser Arg Lys Lys Arg His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Glu Ser Ser Gly Ala Pro Pro Pro Ser Val 
        35                  40                  45              


Ala 
    


<210>  97
<211>  465
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V36 (from VH to the end of JH)

<400>  97
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcg aacgcctgga tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtcggacgg atcaagagca agaccgacgg cggcaccacc      180

gactacgctg cccccgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtatta ctgtaccaca      300

gatctgtcca ggaggaggca ttcacagggc acattcacca gtgactacag caagtatctg      360

gactccaggc gtgcccaaga ttttgtgcag tggttgatga ataccctgcc tatgcccgat      420

gcttttgata tctggggcca agggacaatg gtcaccgtgt cctca                      465


<210>  98
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V36 (from VH to the end of JH)

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Leu Ser Arg Arg Arg His Ser Gln Gly Thr Phe 
            100                 105                 110         


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
        115                 120                 125             


Val Gln Trp Leu Met Asn Thr Leu Pro Met Pro Asp Ala Phe Asp Ile 
    130                 135                 140                 


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
145                 150                 155 


<210>  99
<211>  471
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V66 (from VH to the end of JH)

<400>  99
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcg aacgcctgga tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtcggacgg atcaagagca agaccgacgg cggcaccacc      180

gactacgctg cccccgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtatta ctgtaccaca      300

gatcccgtgc ttaagcattc acagggcaca ttcaccagtg actacagcaa gtatctggac      360

tccaggcgtg cccaagattt tgtgcagtgg ttgatgaata ccctggcgcc tgtaaactac      420

tactactaca tggacgtctg gggcaaaggg accacggtca ccgtgtcctc a               471


<210>  100
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V66 (from VH to the end of JH)

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Pro Val Leu Lys His Ser Gln Gly Thr Phe Thr 
            100                 105                 110         


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
        115                 120                 125             


Gln Trp Leu Met Asn Thr Leu Ala Pro Val Asn Tyr Tyr Tyr Tyr Met 
    130                 135                 140                 


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
145                 150                 155         


<210>  101
<211>  459
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V69 (from VH to the end of JH)

<400>  101
gaagtgcagc tggtggaaag cggaggcgga gtggttcgac ctggcggaag cctgagactg       60

tcttgcgccg ccagcggctt cacctttgac gactacggca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcaactgga acggcggcag caccggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt atcactgtgc gagagcggaa      300

agcgcgggga ggcattcaca gggcacattc accagtgact acagcaagta tctggactcc      360

aggcgtgccc aagattttgt gcagtggttg atgaatacca cttcgatggt gcggtacttc      420

cagcactggg gccagggcac cctggtcacc gtgtcctca                             459


<210>  102
<211>  153
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V69 (from VH to the end of JH)

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Ala Glu Ser Ala Gly Arg His Ser Gln Gly Thr Phe Thr Ser 
            100                 105                 110         


Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln 
        115                 120                 125             


Trp Leu Met Asn Thr Thr Ser Met Val Arg Tyr Phe Gln His Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser 
145                 150             


<210>  103
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V23 (from VH to the end of JH)

<400>  103
caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ccggcagaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtggccgtg atcagctacg acggcagcaa caagtactac      180

gccgacagcg tgaagggccg gttcaccatc tctcgagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagtaatagg      300

cattcacagg gcacattcac cagtgactac agcaagtatc tggactccag gcgtgcccaa      360

gattttgtgc agtggttgat gaataccaag aggaacagga ataacattgc catgcttctt      420

gactactact actacatgga cgtctggggc aaagggacca cggtcaccgt gtcctca         477


<210>  104
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V23 (from VH to the end of JH)

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
            100                 105                 110         


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
        115                 120                 125             


Thr Lys Arg Asn Arg Asn Asn Ile Ala Met Leu Leu Asp Tyr Tyr Tyr 
    130                 135                 140                 


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
145                 150                 155                 


<210>  105
<211>  483
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V74 (from VH to the end of JH)

<400>  105
gaagtgcagc tggtggaaag cggaggcgga gtggttcgac ctggcggaag cctgagactg       60

tcttgcgccg ccagcggctt cacctttgac gactacggca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcaactgga acggcggcag caccggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt atcactgtgc gagagataaa      300

gggattaagc attcacaggg cacattcacc agtgactaca gcaagtatct ggactccagg      360

cgtgcccaag attttgtgca gtggttgatg aataccaaga ggaacaggaa taacattgcc      420

agtaagcagg tgcgatggta cttcgatctc tggggccgtg gcaccctggt cactgtgtcc      480

tca                                                                    483


<210>  106
<211>  161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V74 (from VH to the end of JH)

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Asp Lys Gly Ile Lys His Ser Gln Gly Thr Phe Thr Ser Asp 
            100                 105                 110         


Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp 
        115                 120                 125             


Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala Ser Lys Gln Val 
    130                 135                 140                 


Arg Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
145                 150                 155                 160 


Ser 
    


<210>  107
<211>  510
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V100 (from VH to the end of JH)

<400>  107
caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ccggcagaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtggccgtg atcagctacg acggcagcaa caagtactac      180

gccgacagcg tgaagggccg gttcaccatc tctcgagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatctc      300

tcggatctct cgcacagtgt attactgagg cattcacagg gcacattcac cagtgactac      360

agcaagtatc tggactccag gcgtgcccaa gattttgtgc agtggttgat gaataccaag      420

aggaacagga ataacattgc ccggccgctt gtcctcagcg ctgaatactt ccagcactgg      480

ggccagggca ccctggtcac cgtgtcctca                                       510


<210>  108
<211>  170
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V100 (from VH to the end of JH)

<400>  108

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Asp Leu Ser His Ser Val Leu Leu Arg His Ser 
            100                 105                 110         


Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
        115                 120                 125             


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn 
    130                 135                 140                 


Asn Ile Ala Arg Pro Leu Val Leu Ser Ala Glu Tyr Phe Gln His Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                165                 170 


<210>  109
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V165 (from VH to the end of JH)

<400>  109
caggtgcagc tgcagcagtg gggagccggc ctgctgaagc ccagcgagac actgagcctg       60

acctgcgccg tgtacggcgg cagcttcagc ggctactact ggtcctggat cagacagccc      120

cctggcaagg gcctggaatg gatcggcgag atcaaccaca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatcagc gtggacacct cgaagaacca gttcagcctg      240

aagctgagca gcgtgacagc cgccgacacc gctgtgtatt actgtgcgag aggccccatc      300

ctaaggcccc ggaggcattc acagggcaca ttcaccagtg actacagcaa gtatctggac      360

tccaggcgtg cccaagattt tgtgcagtgg ttgatgaata ccaagaggaa caggaataac      420

attgcccata gtattgtgga ctactggggc cagggaaccc tggtcaccgt gtcctca         477


<210>  110
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V165 (from VH to the end of JH)

<400>  110

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Leu Arg Pro Arg Arg His Ser Gln Gly Thr Phe Thr 
            100                 105                 110         


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
        115                 120                 125             


Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala His Ser 
    130                 135                 140                 


Ile Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
145                 150                 155                 


<210>  111
<211>  468
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITS011-V171 (from VH to the end of JH)

<400>  111
caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ccggcagaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtggccgtg atcagctacg acggcagcaa caagtactac      180

gccgacagcg tgaagggccg gttcaccatc tctcgagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatcgg      300

ttttcccgat ccttttctaa gcattcacag ggcacattca ccagtgacta cagcaagtat      360

ctggactcca ggcgtgccca agattttgtg cagtggttga tgaataccaa gaggaacagg      420

aataacattg ctaactgggg ccagggcacc ctggtcaccg tgtcctca                   468


<210>  112
<211>  156
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V171 (from VH to the end of JH)

<400>  112

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Phe Ser Arg Ser Phe Ser Lys His Ser Gln Gly Thr 
            100                 105                 110         


Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
        115                 120                 125             


Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
    130                 135                 140                 


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
145                 150                 155     


<210>  113
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V165 oxyntomodulin junction

<400>  113

Cys Ala Arg Gly Pro Ile Leu Arg Pro Arg Arg His Ser Gln Gly Thr 
1               5                   10                  15      


Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
            20                  25                  30          


Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
        35                  40                  45              


His Ser Ile Val 
    50          


<210>  114
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITS011-V171 oxyntomodulin junction

<400>  114

Cys Ala Arg Asp Arg Phe Ser Arg Ser Phe Ser Lys His Ser Gln Gly 
1               5                   10                  15      


Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
            20                  25                  30          


Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn Ile 
        35                  40                  45              


Ala Asn 
    50  


