                         SEQUENCE LISTING

<110>  Katholieke Universiteit Leuven
 
<120>  RESISTANCE TO OXIDATIVE STRESS

<130>  913137-IR/AC/FD

<140>  PCT(NYK)
<141>  2014-12-05

<150>  GB1321439.0
<151>  2013-12-05

<150>  GB1410075.4
<151>  2014-06-06

<150>  GB1411118.1
<151>  2014-06-23

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  839
<212>  DNA
<213>  Homo sapiens

<400>  1
aagcagcccg gcccggcatt ttacgacgtt cgcagcgcta cccttttccg ctccacggtg       60

acctccgtgc ggccgggtgc gggcggagtc ttcctcgatc ccgtggtgct ccgcggcgcg      120

gccttgctct cttccggtcg cgggacaccg ggtgtagagg gcggtcgcgg cgggcagtgg      180

cggcagaatg ttggctacca gggtatttag cctagttggc aagcgagcaa tttccacctc      240

tgtgtgtgta cgagctcatg aaagtgttgt gaagagcgaa gacttttcgc tcccagctta      300

tatggatcgg cgtgaccacc ccttgccgga ggtggcccat gtcaagcacc tgtctgccag      360

ccagaaggca ttgaaggaga aggagaaggc ctcctggagc agcctctcca tggatgagaa      420

agtcgagttg tatcgcatta agttcaagga gagctttgct gagatgaaca ggggctcgaa      480

cgagtggaag acggttgtgg gcggtgccat gttcttcatc ggtttcaccg cgctcgttat      540

catgtggcag aagcactatg tgtacggccc cctcccgcaa agctttgaca aagagtgggt      600

ggccaagcag accaagagga tgctggacat gaaggtgaac cccatccagg gcttagcctc      660

caagtgggac tacgaaaaga acgagtggaa gaagtgagag atgctggcct gcgcctgcac      720

ctgcgcctgg ctctgtcacc gccatgcaac tccatgccta tttactggaa acctgttatg      780

ccaaacagtt gtaccactgc taataaatga ccagtttacc tgaaaaaaaa aaaaaaaaa       839


<210>  2
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15      


Thr Ser Val Cys Val Arg Ala His Glu Ser Val Val Lys Ser Glu Asp 
            20                  25                  30          


Phe Ser Leu Pro Ala Tyr Met Asp Arg Arg Asp His Pro Leu Pro Glu 
        35                  40                  45              


Val Ala His Val Lys His Leu Ser Ala Ser Gln Lys Ala Leu Lys Glu 
    50                  55                  60                  


Lys Glu Lys Ala Ser Trp Ser Ser Leu Ser Met Asp Glu Lys Val Glu 
65                  70                  75                  80  


Leu Tyr Arg Ile Lys Phe Lys Glu Ser Phe Ala Glu Met Asn Arg Gly 
                85                  90                  95      


Ser Asn Glu Trp Lys Thr Val Val Gly Gly Ala Met Phe Phe Ile Gly 
            100                 105                 110         


Phe Thr Ala Leu Val Ile Met Trp Gln Lys His Tyr Val Tyr Gly Pro 
        115                 120                 125             


Leu Pro Gln Ser Phe Asp Lys Glu Trp Val Ala Lys Gln Thr Lys Arg 
    130                 135                 140                 


Met Leu Asp Met Lys Val Asn Pro Ile Gln Gly Leu Ala Ser Lys Trp 
145                 150                 155                 160 


Asp Tyr Glu Lys Asn Glu Trp Lys Lys 
                165                 


<210>  3
<211>  3016
<212>  DNA
<213>  Homo sapiens

<400>  3
ctcagacctg tcagcccgcc acactccagc cagtcccttc cgatcacctc cagacaccac       60

gctctccttt cggagcccgc ccgccggaag tggcggcccg gaactactcc cacagggggg      120

cggggaagga agatggcggc gcccagcgtc ccgtgaggag agaggacaca gggatcccgg      180

ggagcggccc cagactcgta aattatggcc gcatctccgc acactctctc ctcacgcctc      240

ctgacaggtt gcgtaggagg ctctgtctgg tatcttgaaa gaagaactat acaggactcc      300

cctcacaagt tcttacatct tctcaggaat gtcaataagc agtggattac atttcagcac      360

tttagcttcc tcaaacgcat gtatgtcaca cagctgaaca gaagccacaa ccagcaagta      420

agacccaagc cagaaccagt agcatctcct ttccttgaaa aaacatcttc aggtcaagcc      480

aaagcagaaa tatatgagat gagacctctc tcaccgccca gcctatcttt gtccagaaag      540

ccaaatgaaa aggaattgat agaactagag ccagactcag taattgaaga ctcaatagat      600

gtagggaaag agacaaaaga ggaaaagcgg tggaaagaga tgaagctgca agtgtatgat      660

ttgccaggaa ttttggctcg actatccaaa atcaaactca cagctctggt tgtaagtacc      720

actgcagctg gatttgcatt ggctccgggc ccttttgact ggccctgttt cctgcttact      780

tctgttggga caggccttgc atcctgtgct gccaactcca tcaatcagtt ttttgaggtg      840

ccatttgact caaacatgaa taggacaaag aacagaccgc tggttcgtgg acagatcagc      900

ccattgctag ctgtgtcctt tgccacttgt tgtgctgttc cgggagttgc cattctgacc      960

ttgggggtga atccactcac aggagccctg gggctcttca acattttcct gtatacctgc     1020

tgctacacac cactgaaaag gatcagcatt gccaacacat gggtcggagc tgtggttggg     1080

gccatcccgc ctgtcatggg ctggacagcg gccacgggca gcctcgatgc tggcgcattt     1140

ctcctgggag gaatcctcta ctcctggcag tttcctcatt tcaacgccct gagctggggc     1200

ctccgtgaag actactcccg gggcggctac tgcatgatgt cggtcaccca cccgggcctg     1260

tgccggcgcg tggcgctgcg ccactgcctg gccctgctcg tgctgtccgc agcagcccct     1320

gtgctggaca tcaccacatg gaccttcccc atcatggccc ttcccatcaa tgcgtacatc     1380

tcctacctcg gcttccgctt ctacgtggac gcagaccgca ggagctcgcg gagactgttc     1440

ttctgcagcc tgtggcacct gccgctgctg ctgctgctca tgctcacctg caagcggccg     1500

agcggaggcg gggacgcagg gccccctccc agctgagagc actgggacgc ccaccgcccc     1560

tttccctccg ctgccaggcg agcatgttgt ggtaattctg gaacacaaga agagaaattg     1620

ctgggtttag aacaagatta taaacgaatt cggtgctcag tgatcacttg acagtttttt     1680

ttttttttaa atattaccca aaatgctccc caaataagaa atgcatcagc tcagtcagtg     1740

aatacaaaaa aggaattatt tttccctttg agggtcttta tacatctctc ctccaacccc     1800

accctctatt ctgtttcttc ctcctcacat gggggtacac atacacagct tcctcttttg     1860

gttccatcct taccaccaca ccacacgcac actccacatg cccagcagag tggcacttgg     1920

tggccagaaa gtgtgagcct catgatctgc tgtctgtagt tctgtgagct caggtccctc     1980

aaaggcctcg gagcaccccc ttcctggtga ctgagccagg gcctgcattt ttggttttcc     2040

ccaccccaca cattctcaac catagtcctt ctaacaatac caatagctag gacccggctg     2100

ctgtgcactg ggactgggga ttccacatgt ttgccttggg agtctcaagc tggactgcca     2160

gcccctgtcc tcccttcacc cccattgcgt atgagcattt cagaactcca aggagtcaca     2220

ggcatcttta tagttcacgt taacatatag acactgttgg aagcagttcc ttctaaaagg     2280

gtagccctgg acttaatacc agccggatac ctctggcccc caccccatta ctgtacctct     2340

ggagtcacta ctgtgggtcg ccactcctct gctacacagc acggcttttt caaggctgta     2400

ttgagaaggg aagttaggaa gaagggtgtg ctgggctaac cagcccacag agctcacatt     2460

cctgtccctt gggtgaaaaa tacatgtcca tcctgatatc tcctgaattc agaaattagc     2520

ctccacatgt gcaatggctt taagagccag aagcagggtt ctgggaattt tgcaagttat     2580

cctgtggcca ggtgtggtct cggttaccaa atacggttac ctgcagcttt ttagtccttt     2640

gtgctcccac gggtctgcag agtcccatct gcccaaaggt cttgaagctt gacaggatgt     2700

tttcattact cagtctccca gggcactgct ggtccgtagg gattcattgg tcggggtggg     2760

agagttaaac aacatttaaa cagagttctc tcaaaaatgt ctaaagggat tgtaggtaga     2820

taacatccaa tcactgtttg cacttatctg aaatcttccc tcttggctgc ccccaggtat     2880

ttactgtgga gaacattgca taggaatgtc tggaaaaagc ctctacaact tgttacagcc     2940

ttcacatttg tacaattcat tgattctctt ttccttccac aataaaatgg tatacaagaa     3000

caaaaaaaaa aaaaaa                                                     3016


<210>  4
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ser Pro His Thr Leu Ser Ser Arg Leu Leu Thr Gly Cys 
1               5                   10                  15      


Val Gly Gly Ser Val Trp Tyr Leu Glu Arg Arg Thr Ile Gln Asp Ser 
            20                  25                  30          


Pro His Lys Phe Leu His Leu Leu Arg Asn Val Asn Lys Gln Trp Ile 
        35                  40                  45              


Thr Phe Gln His Phe Ser Phe Leu Lys Arg Met Tyr Val Thr Gln Leu 
    50                  55                  60                  


Asn Arg Ser His Asn Gln Gln Val Arg Pro Lys Pro Glu Pro Val Ala 
65                  70                  75                  80  


Ser Pro Phe Leu Glu Lys Thr Ser Ser Gly Gln Ala Lys Ala Glu Ile 
                85                  90                  95      


Tyr Glu Met Arg Pro Leu Ser Pro Pro Ser Leu Ser Leu Ser Arg Lys 
            100                 105                 110         


Pro Asn Glu Lys Glu Leu Ile Glu Leu Glu Pro Asp Ser Val Ile Glu 
        115                 120                 125             


Asp Ser Ile Asp Val Gly Lys Glu Thr Lys Glu Glu Lys Arg Trp Lys 
    130                 135                 140                 


Glu Met Lys Leu Gln Val Tyr Asp Leu Pro Gly Ile Leu Ala Arg Leu 
145                 150                 155                 160 


Ser Lys Ile Lys Leu Thr Ala Leu Val Val Ser Thr Thr Ala Ala Gly 
                165                 170                 175     


Phe Ala Leu Ala Pro Gly Pro Phe Asp Trp Pro Cys Phe Leu Leu Thr 
            180                 185                 190         


Ser Val Gly Thr Gly Leu Ala Ser Cys Ala Ala Asn Ser Ile Asn Gln 
        195                 200                 205             


Phe Phe Glu Val Pro Phe Asp Ser Asn Met Asn Arg Thr Lys Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Gly Gln Ile Ser Pro Leu Leu Ala Val Ser Phe Ala 
225                 230                 235                 240 


Thr Cys Cys Ala Val Pro Gly Val Ala Ile Leu Thr Leu Gly Val Asn 
                245                 250                 255     


Pro Leu Thr Gly Ala Leu Gly Leu Phe Asn Ile Phe Leu Tyr Thr Cys 
            260                 265                 270         


Cys Tyr Thr Pro Leu Lys Arg Ile Ser Ile Ala Asn Thr Trp Val Gly 
        275                 280                 285             


Ala Val Val Gly Ala Ile Pro Pro Val Met Gly Trp Thr Ala Ala Thr 
    290                 295                 300                 


Gly Ser Leu Asp Ala Gly Ala Phe Leu Leu Gly Gly Ile Leu Tyr Ser 
305                 310                 315                 320 


Trp Gln Phe Pro His Phe Asn Ala Leu Ser Trp Gly Leu Arg Glu Asp 
                325                 330                 335     


Tyr Ser Arg Gly Gly Tyr Cys Met Met Ser Val Thr His Pro Gly Leu 
            340                 345                 350         


Cys Arg Arg Val Ala Leu Arg His Cys Leu Ala Leu Leu Val Leu Ser 
        355                 360                 365             


Ala Ala Ala Pro Val Leu Asp Ile Thr Thr Trp Thr Phe Pro Ile Met 
    370                 375                 380                 


Ala Leu Pro Ile Asn Ala Tyr Ile Ser Tyr Leu Gly Phe Arg Phe Tyr 
385                 390                 395                 400 


Val Asp Ala Asp Arg Arg Ser Ser Arg Arg Leu Phe Phe Cys Ser Leu 
                405                 410                 415     


Trp His Leu Pro Leu Leu Leu Leu Leu Met Leu Thr Cys Lys Arg Pro 
            420                 425                 430         


Ser Gly Gly Gly Asp Ala Gly Pro Pro Pro Ser 
        435                 440             


<210>  5
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Ser Pro His Thr Leu Ser Ser Arg Leu Leu Thr Gly Cys 
1               5                   10                  15      


Val Gly Gly Ser Val Trp Tyr Leu Glu Arg Arg Thr Ile Gln Asp Ser 
            20                  25                  30          


Pro His Lys Phe Leu His Leu Leu Arg Asn Val Asn Lys Gln Trp Ile 
        35                  40                  45              


Thr Phe Gln His Phe Ser Phe Leu Lys Arg Met Tyr Val Thr Gln Leu 
    50                  55                  60                  


Asn Arg Ser His Asn Gln Gln Val Arg Pro Lys Pro Glu Pro Val Ala 
65                  70                  75                  80  


Ser Pro Phe Leu Glu Lys Thr Ser Ser Gly Gln Ala Lys Ala Glu Ile 
                85                  90                  95      


Tyr Glu Met Arg Pro Leu Ser Pro Pro Ser Leu Ser Leu Ser Arg Lys 
            100                 105                 110         


Pro Asn Glu Lys Glu Leu Ile Glu Leu Glu Pro Asp Ser Val Ile Glu 
        115                 120                 125             


Asp Ser Ile Asp Val Gly Lys Glu Thr Lys Glu Glu Lys Arg Trp Lys 
    130                 135                 140                 


Glu Met Lys Leu Gln Val Tyr Asp Leu Pro Gly Ile Leu Ala Arg Leu 
145                 150                 155                 160 


Ser Lys Ile Lys Leu Thr Ala Leu Val Val Ser Thr Thr Ala Ala Gly 
                165                 170                 175     


Phe Ala Leu Ala Pro Gly Pro Phe Asp Trp Pro Cys Phe Leu Leu Thr 
            180                 185                 190         


Ser Val Gly Thr Gly Leu Ala Ser Cys Ala Ala Asn Ser Ile Asn Gln 
        195                 200                 205             


Phe Phe Glu Val Pro Phe Asp Ser Asn Met Asn Arg Thr Lys Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Gly Gln Ile Ser Pro Leu Leu Ala Val Ser Phe Ala 
225                 230                 235                 240 


Thr Cys Cys Ala Val Pro Gly Val Ala Ile Leu Thr Leu Gly Val Asn 
                245                 250                 255     


Pro Leu Thr Gly Ala Leu Gly Leu Phe Asn Ile Phe Leu Tyr Thr Cys 
            260                 265                 270         


Cys Tyr Thr Pro Leu Lys Arg Ile Ser Ile Ala Asn Thr Trp Val Gly 
        275                 280                 285             


Ala Val Val Gly Ala Ile Pro Pro Val Met Gly Trp Thr Ala Ala Thr 
    290                 295                 300                 


Gly Ser Leu Asp Ala Gly Lys Cys Pro Ala Met Trp Ser Leu Ile 
305                 310                 315                 


<210>  6
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  6
cagttaaaag gaggcgcctg ctggcctccc cttacagtgc ttgttcgggg cgctccgctg       60

gcttcttgga caattgcgcc atgtgtgctg ctcggctagc ggcggcggcg gcggcggccc      120

agtcggtgta tgccttctcg gcgcgcccgc tggccggcgg ggagcctgtg agcctgggct      180

ccctgcgggg caaggtacta cttatcgaga atgtggcgtc cctctgaggc accacggtcc      240

gggactacac ccagatgaac gagctgcagc ggcgcctcgg accccggggc ctggtggtgc      300

tcggcttccc gtgcaaccag tttgggcatc aggagaacgc caagaacgaa gagattctga      360

attccctcaa gtacgtccgg cctggtggtg ggttcgagcc caacttcatg ctcttcgaga      420

agtgcgaggt gaacggtgcg ggggcgcacc ctctcttcgc cttcctgcgg gaggccctgc      480

cagctcccag cgacgacgcc accgcgctta tgaccgaccc caagctcatc acctggtctc      540

cggtgtgtcg caacgatgtt gcctggaact ttgagaagtt cctggtgggc cctgacggtg      600

tgcccctacg caggtacagc cgccgcttcc agaccattga catcgagcct gacatcgaag      660

ccctgctgtc tcaagggccc agctgtgcct agggcgcccc tcctaccccg gctgcttggc      720

agttgcagtg ctgctgtctc gggggggttt tcatctatga gggtgtttcc tctaaaccta      780

cgagggagga acacctgatc ttacagaaaa taccacctcg agatgggtgc tggtcctgtt      840

gatcccagtc tctgccagac caaggcgagt ttccccacta ataaagtgcc gggtgtcagc      900

agaaaaaaaa aaaaaaaaaa a                                                921


<210>  7
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Glu Leu Gln Arg Arg Leu Gly Pro Arg Gly Leu Val Val Leu 
1               5                   10                  15      


Gly Phe Pro Cys Asn Gln Phe Gly His Gln Glu Asn Ala Lys Asn Glu 
            20                  25                  30          


Glu Ile Leu Asn Ser Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe Glu 
        35                  40                  45              


Pro Asn Phe Met Leu Phe Glu Lys Cys Glu Val Ser Gly Ala Gly Ala 
    50                  55                  60                  


His Pro Leu Phe Ala Phe Leu Arg Glu Ala Leu Pro Ala Pro Ser Asp 
65                  70                  75                  80  


Asp Ala Thr Ala Leu Met Thr Asp Pro Lys Leu Ile Thr Trp Ser Pro 
                85                  90                  95      


Val Cys Arg Asn Asp Val Ala Trp Asn Phe Glu Lys Phe Leu Val Gly 
            100                 105                 110         


Pro Asp Gly Val Pro Leu Arg Arg Tyr Ser Arg Arg Phe Gln Thr Ile 
        115                 120                 125             


Asp Ile Glu Pro Asp Ile Glu Ala Leu Leu Ser Gln Gly Leu Ser Cys 
    130                 135                 140                 


Ala 
145 


<210>  8
<211>  8168
<212>  DNA
<213>  Homo sapiens

<400>  8
ctgccgtcgt ggaagcagga tttccgcggt tgtgtaacgg cctgtcgcag gcgtgcaggg       60

acctggactc cgcctcgtcc ccggggctcg ggcagccgag ccatggcggg gaactgtggg      120

gcccgcggcg cgctgtcggc gcacacgctg ctgttcgacc tgccgcccgc gctgctcgga      180

gagctctgcg ctgttctgga cagctgcgac ggcgcgctgg gctggcgcgg cctgggagca      240

gtgttgagtc cttcagagaa gagttatcag gaaggtggat ttccaaatat attattcaag      300

gaaacagcca atgtcaccgt ggataatgtt cttattcctg aacataatga aaaaggaata      360

ctgcttaaat cttccatcag ctttcaaaat atcatagaag gaactagaaa tttccacaaa      420

gacttcctaa ttggagaagg agagattttt gaggtataca gagtggagat tcaaaaccta      480

acatatgctg tcaaattatt taaacaggag aaaaaaatgc agtgtaagaa gcattggaag      540

aggtttttat ctgagcttga agttttacta ctgtttcatc acccaaacat actagagttg      600

gctgcatatt ttacagagac tgagaagttc tgtctgattt atccatacat gagaaatgga      660

acactttttg acagattgca gtgtgtaggt gacacggccc cactcccttg gcacattcga      720

atcggtatat taataggaat atccaaagcc attcactacc tgcacaacgt tcaaccatgc      780

tcggtcatct gtggcagtat atcaagtgca aacatccttt tggatgatca gtttcaaccc      840

aaactaactg attttgccat ggcacacttc cggtcccacc tagaacatca gagttgtacc      900

ataaatatga ccagcagcag cagtaaacat ctgtggtaca tgccagaaga gtacatcaga      960

caggggaaac tttccattaa aacagatgtc tacagctttg gaattgtaat aatggaagtt     1020

ctaacaggat gtagagtagt gttagatgat ccaaaacata tccagctgcg ggatctcctt     1080

agagaattga tggagaagag aggcctggat tcatgtctct catttctaga taagaaagtg     1140

cctccctgcc ctcggaattt ctctgccaag ctcttctgtt tggcaggccg gtgtgctgca     1200

acgcgggcaa agttaagacc atcaatggat gaagttttaa atactcttga aagtactcaa     1260

gccagcttgt attttgctga agatcctccc acatcactaa agtccttcag gtgtccttct     1320

cctctattcc tggagaatgt accaagtatt ccagtggaag atgatgaaag ccagaataac     1380

aatttactac cttctgatga aggcctgagg atagacagaa tgactcagaa aactcctttt     1440

gaatgcagcc agtctgaggt tatgtttctg agcttggaca aaaagccaga gagcaagaga     1500

aatgaggaag cttgcaacat gcccagttct tcttgtgaag aaagttggtt cccaaagtat     1560

atagttccat cccaggactt aaggccctat aaggtaaata tagatccttc ttcagaagct     1620

ccagggcatt cttgcaggag caggccagtg gagagcagct gttcctccaa attttcctgg     1680

gatgaatatg aacagtacaa aaaagaataa attctaccag aagataaaga aaaaagcaag     1740

tattgcatag gcacctgagc ataggtatga ccttgggaag acattggctc cataagcaat     1800

gccaagagaa tgatcaatag tgagtttggg tgatgcagat aaacaatctg gataattcca     1860

tttctttttt cccaaaccct caaacagagt gccttaaaaa attgttttat caggataatt     1920

gtctcatgac caaatccacg ctcaattaga gccattcaaa attccttaag atcatgggtt     1980

ctgacttcag ccaaacaaaa caatcaaaac ctaccaaaaa gggactggat tgtaatgtcc     2040

tctccatcat cctcagtgtg agtcctcaga gcctccatct gccaagaaca ttcagttgga     2100

ttccatcgtt tggtttagct tgcttgcacg ggttgtagga aatgtctaat ttgtaaatgt     2160

taatagatac ctttggaaag aatcaccttg ttattctgat tgacccctct tgttttttgg     2220

ttaatccctg actagcctgc ttgtctgaaa atgagccagg ttcaccctta gctacggcat     2280

gctctgggtt gaaaggggat ttcttcccaa gatctatcct aaactcttag gacagtttat     2340

cctgtattga ctattattac agctttttaa aaacagactt agtgacctat tatatcttaa     2400

ggagactatg tgaaatgtcc atcaagtaat ttttattcct gagaaaatgg ctggtcaagg     2460

gcctaggtca gctttttgtt taatctacac ctttcaactc tgggccttca ttcctgctgt     2520

ttcttggatc tccctctttt gaaatcctac caatcatcag agctctacaa aacagccacc     2580

tcctggaagc ttccctaatc tctacaacca gaagtactcc ctttatcagt atttccacag     2640

caatttcttt gtatttctat tttatattta tcactttctg aattatatca aagctgcttg     2700

tcttatctct tttttttttt gagacggagt ctcgctctgt catccaggct ggagtgcagt     2760

ggcacaatct cggctcaccg caaggtctgc ctcccgggtt cacgccattc tcctgcctca     2820

gcctcccgag taaaggtggg actacaggcg cccgccacta cgcccggcta attttttgta     2880

tttttagtag agacggggtt tcaccatgtt aggcaggatg gtctcgatct cctgacctca     2940

tgatccgcct gcctggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgcccag     3000

ccttcatctc ttttactagg ttgtaaactc cctatattag ttttctattg tttttgtaac     3060

acattatcac aaatttagtg acttaaagta acataaatta attattttgc agttctggag     3120

gtcagaattc cttagcattc tttctggagg ctgttgggga gaactcactg ccttgccttt     3180

tccagcttct agaggccacc tgccttcttt ggctcatggc ctcttcctcc gtcttcaaag     3240

ccagcaacgt gacatttcag atctccctct ctctgtctgt ctcaccgcat ctcttcacta     3300

ccctcttcct ctcattctgg cccttctgca tgtcttttat aaagaccttt gtgatttcac     3360

tgggcccact catataagcc aggaaaatct ctgtgtctca gatccttaat ttaattacac     3420

ctgcaaagtc cgttttctcg tgtaaagtaa catattcaca ggtttctgga attgggacgt     3480

ggacatcttc gggggaccat tactctgtct gtcatactcc ctgagtgtgt aagggccatc     3540

tcttcagagc ctaatgtgtc atcctacaca gagcaggtgt ttccttataa attaagttga     3600

attaaattac ccctatgaag ccacataatc aataattcag ctataataaa cattgccgaa     3660

taaattaaca aagggaggat aatgactcct tatgatgatg gatagaaaca ctgaagaaaa     3720

ccattttcag aggatttact gaattttcct ctccaaggag cttgtaatag aagggtaaac     3780

ctctagtttc ttgtccagca gaggaatagg ctcatgtctt ttgttttatt ttattttttt     3840

ggtgagtcag tatggttggg ttaatcatat tcacattaga ttccatgttg aagaacaact     3900

aatcaaagaa gaaaatcatc aggaatcagg gtgagattaa cagaccaagg tcagaaacat     3960

ggagttacaa ttttccaaaa aagcacgaag tgagattaaa accacagtaa gtcttagtct     4020

gactgacagg ctttatacag gccctcggta agcagttggg agaacccatg cccaccactg     4080

ctctgtacgg tatctggctg ctcagagctc tctgattcac aaaagagatc atcaagaatt     4140

gactctgtgt taaactgttt ttcacttaga atatggaccc ccaccaatac attcaatgaa     4200

gggtcattaa ggaagctctg attaacacca ggcccatgca gttactccgc acatataatc     4260

tgtgggtatt atgttgattt gaacttgctt agctgactta aagcagggtt tctcaaactg     4320

tagtatgcat cagaatgact tggaaagctg gttaaaaacg cagattgctg ggtccaccca     4380

gcttctgatg caataggtct ggggttagaa attttgcttt ctaatgagtt cccaggtgat     4440

gctgatgcca atgatgtgaa gcccgctctt cacatccgtg aaaatcgctg ccttaaggtg     4500

ctcttaaatt gttatagatt ggtagatcct acctttccat cactggtatg ttttttgaga     4560

aaaggatcct ttcttttcat tctgttatat tcatcctatt acataggatg ttggttagca     4620

cagagtggga gctctagaaa gattgttgac caatcatctt attgactaga ccatctttct     4680

agagtataac tattttggac acctcaaaga tgaagtcaga taagctggca gtgacctgat     4740

taacgttgtg gtaagcagat gccactgtgg ctgggaagta ccaaatcttc tgttgagtga     4800

ttcagtcttc ctgactagat ttgccttcta gtgggtgtat taataagcgt tagttgatat     4860

gaattaaatg ttgcaacttt ctatgggtaa taagaggata cctttatagt ttcatgatgt     4920

ggagaccaag atacataaga aagcaagaat gagtctccgg gtgttccctc tgatcagcaa     4980

acatgaattc ataatttcat ttactctcat ttttgtaatg cactctgagc aatcctccag     5040

gcagatccta tttactaagc ttcaggcttt tgtcccattt tataatgccc aaacacatgg     5100

agaaaacatt ttgttgtttt taaaaacagg tatgggattt ctgatataat caattttatt     5160

gacttcttgg gagttgtaat gatctgtgac tcactgcata atattgtagt tttatagggt     5220

ggcacatcac cctgtgtaaa acaactttaa tgacctgagg actgatgagt acaggaagtg     5280

aggtttatca tgagtagcat ttattaagca tctgctagaa tcaaagcact gcattagcta     5340

ctaaggtaca aagtaagaca cagtttaata aggaagacag ggcatctacc caagtcaaca     5400

gttcagtgac atctgttatt tgaaccacac accaatgcaa ccgaagtaaa tgctgaaagg     5460

gtgagaagaa ggaatagatt actatgcatt tttgagagga tgaagaaggc ttcttggaga     5520

aggtttctga aaagagatac ggaattaaga gaaatagaaa agagcactga cgaagcactc     5580

aggatggcta ttcaaggaat tggggatcca cagcagctgt gcacaaccat ccctaatgcc     5640

agaaaaatgg ggtaagggtg aagggaactg ggtctagagc tttgcatgtt tttttctggt     5700

taacccttag agtcaccctg aaggtgtgga tcccatctta taataaggtg aggacactga     5760

gtcaggaaac taacttgcta aaatcaagtc ctcccagtcc tcccatcagg tccttccaga     5820

tctggaggag ccaggatttg aactcacatt tgtctgactt caaaatccat gctttttctt     5880

gtgttccaaa ttgcacaatg gagtcactgc cagttcaagc tcctatgaaa agggatggat     5940

gtgaaaagtc atttgttgat tccacagatt tttagtaggt accatgtctc ctgcctttat     6000

cactatccta ctcctctgct acaacttctc tgctacaggc acccactgca gttacttgat     6060

atgagttaaa tgaatccatc catccaaact tccattcatt gaataaatac ttagcaatgg     6120

cttcctttgt atcaggcact attctaggag ctggggctac agtgcagatg gaaaccagca     6180

aagctcactg ccctcatgga gcttatatgt aagtgaataa atctcagggt ggttctcctg     6240

tcataggtcc tggctcctct gccagctctt ccaaatgggt tcagagaggt tttctccttg     6300

tcctgttgtg taactgataa tcccatggtg gacctcactt tgctattcat atgcactaag     6360

tagtttatgg tgtgctttgt ggctggcaat tgtgacagat tctattcttc tattggtatg     6420

tggtttcttt ggggcatttg tttggatact gatggcatct tccgggggtc tgaggcacct     6480

acacaaacct caggtcacta tcacgtgata ctggagttgc ctgttaaatt atatttcttc     6540

ttccacaaaa ctgcaggttc cctgagggaa aggtctatgt cctgctcatt tttggatccc     6600

taatggctgg cacagtacct ggtgcataat atggttcaac aaatatttgt aaaatgaatg     6660

aatcaaatag tccttcaaag catcttcaga atcaagattg tcatctagat tgcacccgaa     6720

gtttatcttt ctagtattca gaatataatc aatcattgct taaattattc catttcatca     6780

ttcttgaata aaagctacta attttaaata ctaatatctg agatatcttc gaaaagaaga     6840

ttagtcgttg tatgtgttgc ttataaattt tctctatggt ggaaaatatt cccaaaccat     6900

gtctaagcaa tgaaaaacca gtgttctggc aggaaataaa ctgatgtttg ttgtgttttg     6960

tatctgtctt cccgttccaa atcatttata tatacttgat ggtctgtggg cttgacttgc     7020

aagtattttc ctgggagaca tttttattca aaagacctgt attgcctgcc aaaccttcat     7080

ttaagagact cattatggat gtcatctgca tcattgcaaa cttttctggt cgtctctata     7140

aatagcaaga taatatttac agagttttac attggctctt gaattttaaa atattcttat     7200

agacaaacat taattggaat ggggggtaag gaggtaggaa tggcttactt gcggaaatgc     7260

aggctcattg ttgtgtctag taggtgctag gtgcattcac acatctctta agctttaaac     7320

aacctattga gccggtttcc atttccttga tctattagat ttaaaaaaat gaagcataaa     7380

ggagttggct cttgccctaa gtcatactac tgatggaatg agaatacaaa ccaaaaacac     7440

tttattcaag tccaggaaat atctgccttg aaaaagaata acttaaaaat taaaagtgtc     7500

ctctatttga acatgaaaac agctaataaa gatgtgttat tttattttat tattattaat     7560

tttgtcctcc catattggca aagataaagc aattgacaaa aatggaattc ttgttcaata     7620

ctggcaggag tgaaaattgg tagaaccttt ctagaaggca atttggcaac atgtatgaaa     7680

acctaaatgt tgatacacct ttacccagca gtttgtttag gaatttatcc taatgaataa     7740

aagttgtcca agtcttcaaa catgagccca aaggtatatt tcatgatgtt tatgatatta     7800

aaacattgga aacaactgaa acatccttca gtaaaagatg gattaaataa attccatgca     7860

gttgtcattt aaaaatattt agatatatgt ttattgctat ggatatatgt tcccaaaata     7920

ttattgaatc aaaaagtaga ctacaggata tatgttgaat atgagctcat ttataacatt     7980

gaatatttta agataatgta tgtttcatag agagatcttc accaaatgtt aaggattttt     8040

ttttctgggc tgtggtattt gggtgatctt tacattcttc agactcatgt gtgtttgaaa     8100

ctttttataa tgaacatata tcatttttat tagaaaagaa taaagttttt gaaaaaaaaa     8160

aaaaaaaa                                                              8168


<210>  9
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Ala Glu Arg Leu 
        35                  40                  45              


Ser Ser Ser Trp Leu Asp Val Arg His Ile Glu Lys Tyr Val Asp Gln 
    50                  55                  60                  


Gly Lys Ser Gly Thr Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys Asn 
65                  70                  75                  80  


Lys Thr Ile Gly Asp Leu Leu Gln Val Leu Gln Glu Met Gly His Arg 
                85                  90                  95      


Arg Ala Ile His Leu Ile Thr Asn Tyr Gly Ala Val Leu Ser Pro Ser 
            100                 105                 110         


Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu Phe Lys Glu 
        115                 120                 125             


Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu His Asn Glu 
    130                 135                 140                 


Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn Ile Ile Glu 
145                 150                 155                 160 


Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu Gly Glu Ile 
                165                 170                 175     


Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr Ala Val Lys 
            180                 185                 190         


Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His Trp Lys Arg 
        195                 200                 205             


Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His Pro Asn Ile 
    210                 215                 220                 


Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe Cys Leu Ile 
225                 230                 235                 240 


Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu Gln Cys Val 
                245                 250                 255     


Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly Ile Leu Ile 
            260                 265                 270         


Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln Pro Cys Ser 
        275                 280                 285             


Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu Asp Asp Gln 
    290                 295                 300                 


Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe Arg Ser His 
305                 310                 315                 320 


Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser Ser Ser Lys 
                325                 330                 335     


His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly Lys Leu Ser 
            340                 345                 350         


Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met Glu Val Leu 
        355                 360                 365             


Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile Gln Leu Arg 
    370                 375                 380                 


Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp Ser Cys Leu 
385                 390                 395                 400 


Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn Phe Ser Ala 
                405                 410                 415     


Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg Ala Lys Leu 
            420                 425                 430         


Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser Thr Gln Ala 
        435                 440                 445             


Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys Ser Phe Arg 
    450                 455                 460                 


Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile Pro Val Glu 
465                 470                 475                 480 


Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp Glu Gly Leu 
                485                 490                 495     


Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys Ser Gln Ser 
            500                 505                 510         


Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser Lys Arg Asn 
        515                 520                 525             


Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu Ser Trp Phe 
    530                 535                 540                 


Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr Lys Val Asn 
545                 550                 555                 560 


Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg Ser Arg Pro 
                565                 570                 575     


Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu Tyr Glu Gln 
            580                 585                 590         


Tyr Lys Lys Glu 
        595     


<210>  10
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Gly Ala Val Leu 
        35                  40                  45              


Ser Pro Ser Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu 
    50                  55                  60                  


Phe Lys Glu Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu 
65                  70                  75                  80  


His Asn Glu Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn 
                85                  90                  95      


Ile Ile Glu Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu 
            100                 105                 110         


Gly Glu Ile Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr 
        115                 120                 125             


Ala Val Lys Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His 
    130                 135                 140                 


Trp Lys Arg Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His 
145                 150                 155                 160 


Pro Asn Ile Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe 
                165                 170                 175     


Cys Leu Ile Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu 
            180                 185                 190         


Gln Cys Val Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly 
        195                 200                 205             


Ile Leu Ile Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln 
    210                 215                 220                 


Pro Cys Ser Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu 
225                 230                 235                 240 


Asp Asp Gln Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe 
                245                 250                 255     


Arg Ser His Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser 
            260                 265                 270         


Ser Ser Lys His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly 
        275                 280                 285             


Lys Leu Ser Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met 
    290                 295                 300                 


Glu Val Leu Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile 
305                 310                 315                 320 


Gln Leu Arg Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp 
                325                 330                 335     


Ser Cys Leu Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn 
            340                 345                 350         


Phe Ser Ala Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg 
        355                 360                 365             


Ala Lys Leu Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser 
    370                 375                 380                 


Thr Gln Ala Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys 
385                 390                 395                 400 


Ser Phe Arg Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile 
                405                 410                 415     


Pro Val Glu Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp 
            420                 425                 430         


Glu Gly Leu Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys 
        435                 440                 445             


Ser Gln Ser Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser 
    450                 455                 460                 


Lys Arg Asn Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu 
465                 470                 475                 480 


Ser Trp Phe Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr 
                485                 490                 495     


Lys Val Asn Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg 
            500                 505                 510         


Ser Arg Pro Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu 
        515                 520                 525             


Tyr Glu Gln Tyr Lys Lys Glu 
    530                 535 


<210>  11
<211>  4934
<212>  DNA
<213>  Homo sapiens

<400>  11
atgggctgga gctccgggca gtgtgcgagg cgcacgcaca ggagcctgca ctctgcgtcc       60

cgcaccccag cagccgcgcc atgagccgga gtctcttgct ctggttcttg ctgttcctgc      120

tcctgctccc gccgctcccc gtcctgctcg cggacccagg ggcgcccacg ccagtgaatc      180

cctgttgtta ctatccatgc cagcaccagg gcatctgtgt ccgcttcggc cttgaccgct      240

accagtgtga ctgcacccgc acgggctatt ccggccccaa ctgcaccatc cctggcctgt      300

ggacctggct ccggaattca ctgcggccca gcccctcttt cacccacttc ctgctcactc      360

acgggcgctg gttctgggag tttgtcaatg ccaccttcat ccgagagatg ctcatgcgcc      420

tggtactcac agtgcgctcc aaccttatcc ccagtccccc cacctacaac tcagcacatg      480

actacatcag ctgggagtct ttctccaacg tgagctatta cactcgtatt ctgccctctg      540

tgcctaaaga ttgccccaca cccatgggaa ccaaagggaa gaagcagttg ccagatgccc      600

agctcctggc ccgccgcttc ctgctcagga ggaagttcat acctgacccc caaggcacca      660

acctcatgtt tgccttcttt gcacaacact tcacccacca gttcttcaaa acttctggca      720

agatgggtcc tggcttcacc aaggccttgg gccatggggt agacctcggc cacatttatg      780

gagacaatct ggagcgtcag tatcaactgc ggctctttaa ggatgggaaa ctcaagtacc      840

aggtgctgga tggagaaatg tacccgccct cggtagaaga ggcgcctgtg ttgatgcact      900

acccccgagg catcccgccc cagagccaga tggctgtggg ccaggaggtg tttgggctgc      960

ttcctgggct catgctgtat gccacgctct ggctacgtga gcacaaccgt gtgtgtgacc     1020

tgctgaaggc tgagcacccc acctggggcg atgagcagct tttccagacg acccgcctca     1080

tcctcatagg ggagaccatc aagattgtca tcgaggagta cgtgcagcag ctgagtggct     1140

atttcctgca gctgaaattt gacccagagc tgctgttcgg tgtccagttc caataccgca     1200

accgcattgc catggagttc aaccatctct accactggca ccccctcatg cctgactcct     1260

tcaagatcgg tgggggcagg aacatggacc accacatcct gcatgtggct gtggatgtca     1320

tcagggagtc tcgggagatg cggctgcagc ccttcaatga gtaccgcaag aggtttggca     1380

tgaaacccta cacctccttc caggagctcg taggagagaa ggagatggca gcagagttgg     1440

aggaattgta tggagacatt gatgcgttgg agttctaccc tggactgctt cttgaaaagt     1500

gccatccaaa ctctatcttt ggggagagta tgatagagat tggggctccc ttttccctca     1560

agggtctcct agggaatccc atctgttctc cggagtactg gaagccgagc acatttggcg     1620

gcgaggtggg ctttaacatt gtcaagacgg ccacactgaa gaagctggtc tgcctcaaca     1680

ccaagacctg tccctacgtt tccttccgtg tgccggatgc cagtcaggat gatgggcctg     1740

ctgtggagcg accatccaca gagctctgag gggcaggaaa gcagcattct ggaggggaga     1800

gctttgtgct tgtcattcca gagtgctgag gccagggctg atggtcttaa atgctcattt     1860

tctggtttgg catggtgagt gttggggttg acatttagaa ctttaagtct cacccattat     1920

ctggaatatt gtgattctgt ttattcttcc agaatgctga actccttgtt agcccttcag     1980

attgttagga gtggttctca tttggtctgc cagaatactg ggttcttagt tgacaaccta     2040

gaatgtcaga tttctggttg atttgtaaca cagtcattct aggatgtgga gctactgatg     2100

aaatctgcta gaaagttagg gggttcttat tttgcattcc agaatcttga ctttctgatt     2160

ggtgattcaa agtgttgtgt tcctggctga tgatccagaa cagtggctcg tatcccaaat     2220

ctgtcagcat ctggctgtct agaatgtgga tttgattcat tttcctgttc agtgagatat     2280

catagagacg gagatcctaa ggtccaacaa gaatgcattc cctgaatctg tgcctgcact     2340

gagagggcaa ggaagtgggg tgttcttctt gggaccccca ctaagaccct ggtctgagga     2400

tgtagagaga acaggtgggc tgtattcacg ccattggttg gaagctacca gagctctatc     2460

cccatccagg tcttgactca tggcagctgt ttctcatgaa gctaataaaa ttcgctttct     2520

aaagttacct gttatatatc tcttttggtc ccatcctcta aagcagaggc aacactggaa     2580

catggctagc ctttcttgta gccatggctg ggcgtgctag aggttgcagc atgagacttt     2640

ctgctgggat ccttgggccc atcactgtat agacatgcta ccactggtac ttcctttctc     2700

cctgcgggcc aggcactgcc cttttcagga agctctctta aaatacccat tgccccagac     2760

ctggaagata taacattcag ttcccaccat ctgattaaaa caacttcctc ccttacagag     2820

catacaacag agggggcacc cggggaggag agcacatact gtgttccaat ttcacgcttt     2880

taattctcat ttgttctcac accaacagtg tgaagtgcgt ggtataatct ccatttcaaa     2940

accaaggaag cagcctcaga gtggtcgagt gacacacctc acgcaggctg agtccagagc     3000

ttgtgctcct cttgattcct ggtttgactc agttccaggc ctgatcttgc ctgtctggct     3060

cagggtcaaa gacagaatgg tggagtgtag cctccacctg atattcaggc tactcattca     3120

gtcccaaata tgtattttcc taagtgttta ctatgtgcca gttcctgtaa caggtgtggg     3180

gacacagcag tgagtaatca atacagacaa ggttctgccc ttatggagct cacactccag     3240

tggcagacaa acagaccata aataaggaaa cgatgaaata agatatatac aaggtgagtg     3300

tgacttccct tctaaccccc tctgctctgt cctcccctat tgcgctctca agaccagaga     3360

cccaacagca gtgatctcag ggcagacagc cctccactcc agctctgaga cccttttctc     3420

aggacctctg taggcagcag agagagagga cagaggggta agatgagggg ttgagggaag     3480

gttcttcatg atccacactt tgggcttagt atttctcagg aagagctatg gcccagaaac     3540

aacaggggaa actagagttc ggtctgacag tccttggggt taagtctcct gtcttatggt     3600

ccagaaactc ctgtttctcc ttagttggct ggaaactgct cccatcattc cttctggcct     3660

ctgctgaatg cagggaatgc aatccttccc tgctcttgca gttgctctga cgtagaaaga     3720

tccttcgggt gctggaagtc tccatgaaga gcttgtgtcc tgtcctttct tgcagattct     3780

atttcccctc ttctgctaat acctcttact ttgcttgaga atcctctcct ttcttattaa     3840

tttcagtctt ggtggttcta tcaggggtgc attctggcca aggggtgggc ctgtgaatca     3900

atcctgggca atcagacacc ctctccttaa aaactggccc gtggagactg agatcactga     3960

ctctgactca tccccacagc tggctctgac aagatggtcc atttgttcct gcttccgaga     4020

tccccagggc agcctggatc cctgcccttc tcaagacttt agcttttcct tccatccggt     4080

ggcctattcc aggaattcct cttttgctta aatcagttgg agtttgtgtc tgttgcttgt     4140

aatcaagcct ttatggctgc tgggctgagt gacacaagca ctttaatggc ctggagggac     4200

ttttaatcag tgaagatgca atcagacaag tgttttggaa agagcaccct cgagaagggt     4260

ggatgacagg gcagagcagg aaggacagga agctggcaga acggaggagg ctgcagccgt     4320

ggtccaacca ggagctgatg gcagctgggg ctaggggaag ggctttgagg gtggaaggat     4380

gggatgggtt ccagaggtat tcctctctta aatgcaagtg cctagattag gtagactttg     4440

cttagtattg acaactgcac atgaaagttt tgcaaaggga aacaggctaa atgcaccaag     4500

aaagcttctt cagagtgaag aatcttaatg cttgtaattt aaacatttgt tcctggagtt     4560

ttgatttggt ggatgtgatg gttggtttta tttgtcagtt tggttgggct atagcacaca     4620

gttatttaat caaacagtaa tctaggtgtg gctgtgaagg tattttgtag atgtgattaa     4680

catctacaat cagttgactt taagtgaaag agattactta aataatttgg gtgagctgca     4740

cctgattagt tgaaaggcct caagaacaaa cactgcagtt tcctggaaaa gaagaaactt     4800

tgcctcaaga ctatagccat cgactcctgc ctgagtttcc agcctgctag tctgccctat     4860

ggatttgaag tttgccaacc ccaacaattg tgtgaattaa tttctaaaaa taaagctata     4920

tacagccaaa aaaa                                                       4934


<210>  12
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Arg Ser Leu Leu Leu Arg Phe Leu Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 
            20                  25                  30          


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 
        35                  40                  45              


Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
    50                  55                  60                  


Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 
65                  70                  75                  80  


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 
                85                  90                  95      


Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 
            100                 105                 110         


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
        115                 120                 125             


Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
    130                 135                 140                 


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
145                 150                 155                 160 


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 
                165                 170                 175     


Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 
            180                 185                 190         


Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
        195                 200                 205             


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
    210                 215                 220                 


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 
225                 230                 235                 240 


Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
                245                 250                 255     


Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 
            260                 265                 270         


His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 
        275                 280                 285             


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 
    290                 295                 300                 


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 
305                 310                 315                 320 


Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
                325                 330                 335     


Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 
            340                 345                 350         


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 
        355                 360                 365             


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 
    370                 375                 380                 


His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu 
385                 390                 395                 400 


Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 
                405                 410                 415     


Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg 
            420                 425                 430         


Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val 
        435                 440                 445             


Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu 
    450                 455                 460                 


Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu 
465                 470                 475                 480 


Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 
                485                 490                 495     


Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His 
            500                 505                 510         


Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe 
        515                 520                 525             


Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 
    530                 535                 540                 


Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr 
545                 550                 555                 560 


Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 
                565                 570                 575     


Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val 
            580                 585                 590         


Glu Arg Pro Ser Thr Glu Leu 
        595                 


<210>  13
<211>  4507
<212>  DNA
<213>  Homo sapiens

<400>  13
gaccaattgt catacgactt gcagtgagcg tcaggagcac gtccaggaac tcctcagcag       60

cgcctccttc agctccacag ccagacgccc tcagacagca aagcctaccc ccgcgccgcg      120

ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct gtgcgcggtc ctggcgctca      180

gccatacagc aaatccttgc tgttcccacc catgtcaaaa ccgaggtgta tgtatgagtg      240

tgggatttga ccagtataag tgcgattgta cccggacagg attctatgga gaaaactgct      300

caacaccgga atttttgaca agaataaaat tatttctgaa acccactcca aacacagtgc      360

actacatact tacccacttc aagggatttt ggaacgttgt gaataacatt cccttccttc      420

gaaatgcaat tatgagttat gtgttgacat ccagatcaca tttgattgac agtccaccaa      480

cttacaatgc tgactatggc tacaaaagct gggaagcctt ctctaacctc tcctattata      540

ctagagccct tcctcctgtg cctgatgatt gcccgactcc cttgggtgtc aaaggtaaaa      600

agcagcttcc tgattcaaat gagattgtgg aaaaattgct tctaagaaga aagttcatcc      660

ctgatcccca gggctcaaac atgatgtttg cattctttgc ccagcacttc acgcatcagt      720

ttttcaagac agatcataag cgagggccag ctttcaccaa cgggctgggc catggggtgg      780

acttaaatca tatttacggt gaaactctgg ctagacagcg taaactgcgc cttttcaagg      840

atggaaaaat gaaatatcag ataattgatg gagagatgta tcctcccaca gtcaaagata      900

ctcaggcaga gatgatctac cctcctcaag tccctgagca tctacggttt gctgtggggc      960

aggaggtctt tggtctggtg cctggtctga tgatgtatgc cacaatctgg ctgcgggaac     1020

acaacagagt atgcgatgtg cttaaacagg agcatcctga atggggtgat gagcagttgt     1080

tccagacaag caggctaata ctgataggag agactattaa gattgtgatt gaagattatg     1140

tgcaacactt gagtggctat cacttcaaac tgaaatttga cccagaacta cttttcaaca     1200

aacaattcca gtaccaaaat cgtattgctg ctgaatttaa caccctctat cactggcatc     1260

cccttctgcc tgacaccttt caaattcatg accagaaata caactatcaa cagtttatct     1320

acaacaactc tatattgctg gaacatggaa ttacccagtt tgttgaatca ttcaccaggc     1380

aaattgctgg cagggttgct ggtggtagga atgttccacc cgcagtacag aaagtatcac     1440

aggcttccat tgaccagagc aggcagatga aataccagtc ttttaatgag taccgcaaac     1500

gctttatgct gaagccctat gaatcatttg aagaacttac aggagaaaag gaaatgtctg     1560

cagagttgga agcactctat ggtgacatcg atgctgtgga gctgtatcct gcccttctgg     1620

tagaaaagcc tcggccagat gccatctttg gtgaaaccat ggtagaagtt ggagcaccat     1680

tctccttgaa aggacttatg ggtaatgtta tatgttctcc tgcctactgg aagccaagca     1740

cttttggtgg agaagtgggt tttcaaatca tcaacactgc ctcaattcag tctctcatct     1800

gcaataacgt gaagggctgt ccctttactt cattcagtgt tccagatcca gagctcatta     1860

aaacagtcac catcaatgca agttcttccc gctccggact agatgatatc aatcccacag     1920

tactactaaa agaacgttcg actgaactgt agaagtctaa tgatcatatt tatttattta     1980

tatgaaccat gtctattaat ttaattattt aataatattt atattaaact ccttatgtta     2040

cttaacatct tctgtaacag aagtcagtac tcctgttgcg gagaaaggag tcatacttgt     2100

gaagactttt atgtcactac tctaaagatt ttgctgttgc tgttaagttt ggaaaacagt     2160

ttttattctg ttttataaac cagagagaaa tgagttttga cgtcttttta cttgaatttc     2220

aacttatatt ataagaacga aagtaaagat gtttgaatac ttaaacactg tcacaagatg     2280

gcaaaatgct gaaagttttt acactgtcga tgtttccaat gcatcttcca tgatgcatta     2340

gaagtaacta atgtttgaaa ttttaaagta cttttggtta tttttctgtc atcaaacaaa     2400

aacaggtatc agtgcattat taaatgaata tttaaattag acattaccag taatttcatg     2460

tctacttttt aaaatcagca atgaaacaat aatttgaaat ttctaaattc atagggtaga     2520

atcacctgta aaagcttgtt tgatttctta aagttattaa acttgtacat ataccaaaaa     2580

gaagctgtct tggatttaaa tctgtaaaat cagtagaaat tttactacaa ttgcttgtta     2640

aaatatttta taagtgatgt tcctttttca ccaagagtat aaaccttttt agtgtgactg     2700

ttaaaacttc cttttaaatc aaaatgccaa atttattaag gtggtggagc cactgcagtg     2760

ttatcttaaa ataagaatat tttgttgaga tattccagaa tttgtttata tggctggtaa     2820

catgtaaaat ctatatcagc aaaagggtct acctttaaaa taagcaataa caaagaagaa     2880

aaccaaatta ttgttcaaat ttaggtttaa acttttgaag caaacttttt tttatccttg     2940

tgcactgcag gcctggtact cagattttgc tatgaggtta atgaagtacc aagctgtgct     3000

tgaataatga tatgttttct cagattttct gttgtacagt ttaatttagc agtccatatc     3060

acattgcaaa agtagcaatg acctcataaa atacctcttc aaaatgctta aattcatttc     3120

acacattaat tttatctcag tcttgaagcc aattcagtag gtgcattgga atcaagcctg     3180

gctacctgca tgctgttcct tttcttttct tcttttagcc attttgctaa gagacacagt     3240

cttctcatca cttcgtttct cctattttgt tttactagtt ttaagatcag agttcacttt     3300

ctttggactc tgcctatatt ttcttacctg aacttttgca agttttcagg taaacctcag     3360

ctcaggactg ctatttagct cctcttaaga agattaaaag agaaaaaaaa aggccctttt     3420

aaaaatagta tacacttatt ttaagtgaaa agcagagaat tttatttata gctaatttta     3480

gctatctgta accaagatgg atgcaaagag gctagtgcct cagagagaac tgtacggggt     3540

ttgtgactgg aaaaagttac gttcccattc taattaatgc cctttcttat ttaaaaacaa     3600

aaccaaatga tatctaagta gttctcagca ataataataa tgacgataat acttcttttc     3660

cacatctcat tgtcactgac atttaatggt actgtatatt acttaattta ttgaagatta     3720

ttatttatgt cttattagga cactatggtt ataaactgtg tttaagccta caatcattga     3780

tttttttttg ttatgtcaca atcagtatat cttctttggg gttacctctc tgaatattat     3840

gtaaacaatc caaagaaatg attgtattaa gatttgtgaa taaattttta gaaatctgat     3900

tggcatattg agatatttaa ggttgaatgt ttgtccttag gataggccta tgtgctagcc     3960

cacaaagaat attgtctcat tagcctgaat gtgccataag actgaccttt taaaatgttt     4020

tgagggatct gtggatgctt cgttaatttg ttcagccaca atttattgag aaaatattct     4080

gtgtcaagca ctgtgggttt taatattttt aaatcaaacg ctgattacag ataatagtat     4140

ttatataaat aattgaaaaa aattttcttt tgggaagagg gagaaaatga aataaatatc     4200

attaaagata actcaggaga atcttcttta caattttacg tttagaatgt ttaaggttaa     4260

gaaagaaata gtcaatatgc ttgtataaaa cactgttcac tgtttttttt aaaaaaaaaa     4320

cttgatttgt tattaacatt gatctgctga caaaacctgg gaatttgggt tgtgtatgcg     4380

aatgtttcag tgcctcagac aaatgtgtat ttaacttatg taaaagataa gtctggaaat     4440

aaatgtctgt ttatttttgt actatttaaa aattgacaga tcttttctga agaaaaaaaa     4500

aaaaaaa                                                               4507


<210>  14
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  15
<211>  5487
<212>  DNA
<213>  Homo sapiens

<400>  15
gtgtgaatgc ttcattcgcc tcacaaacaa ccacagaacc acaagtgcgg tgcaaacttt       60

ctccaggagg acagcaagaa gtctctggtt tttaaatggt taatctccgc aggtcactac      120

cagccaccga gaccaacaga gtcatttaag gctgcaagca gtatttacaa cagagggtac      180

aagttctatc tgaaaaaaaa aggagggact atggcatcaa acagcctctt cagcacagtg      240

acaccatgtc agcaaaactt cttttgggat ccgagcacca gccggcgctt cagccccccc      300

tccagcagcc tgcagcccgg caaaatgagc gacgtgagcc cggtggtggc tgcgcaacag      360

cagcagcaac agcagcagca gcaacagcag cagcagcagc agcaacagca gcagcagcag      420

caggaggcgg cggcggcggc tgcggcggcg gcggcggctg cggcggcggc agctgcagtg      480

ccccggttgc ggccgcccca cgacaaccgc accatggtgg agatcatcgc cgaccacccg      540

gccgaactcg tccgcaccga cagccccaac ttcctgtgct cggtgctgcc ctcgcactgg      600

cgctgcaaca agaccctgcc cgtggccttc aaggtggtag ccctcggaga ggtaccagat      660

gggactgtgg ttactgtcat ggcgggtaac gatgaaaatt attctgctga gctccggaat      720

gcctctgctg ttatgaaaaa ccaagtagca aggttcaacg atctgagatt tgtgggccgg      780

agtggacgag gcaagagttt caccttgacc ataaccgtct tcacaaatcc tccccaagta      840

gctacctatc acagagcaat taaagttaca gtagatggac ctcgggaacc cagaaggcac      900

agacagaagc ttgatgactc taaacctagt ttgttctctg accgcctcag tgatttaggg      960

cgcattcctc atcccagtat gagagtaggt gtcccgcctc agaacccacg gccctccctg     1020

aactctgcac caagtccttt taatccacaa ggacagagtc agattacaga ccccaggcag     1080

gcacagtctt ccccgccgtg gtcctatgac cagtcttacc cctcctacct gagccagatg     1140

acgtccccgt ccatccactc taccaccccg ctgtcttcca cacggggcac tgggcttcct     1200

gccatcaccg atgtgcctag gcgcatttca ggtgcttcag aactgggccc tttttcagac     1260

cccaggcagt tcccaagcat ttcatccctc actgagagcc gcttctccaa cccacgaatg     1320

cactatccag ccacctttac ttacaccccg ccagtcacct caggcatgtc cctcggtatg     1380

tccgccacca ctcactacca cacctacctg ccaccaccct accccggctc ttcccaaagc     1440

cagagtggac ccttccagac cagcagcact ccatatctct actatggcac ttcgtcagga     1500

tcctatcagt ttcccatggt gccgggggga gaccggtctc cttccagaat gcttccgcca     1560

tgcaccacca cctcgaatgg cagcacgcta ttaaatccaa atttgcctaa ccagaatgat     1620

ggtgttgacg ctgatggaag ccacagcagt tccccaactg ttttgaattc tagtggcaga     1680

atggatgaat ctgtttggcg accatattga aattcctcag cagtggccca gtggtatctg     1740

ggggccacat cccacacgta tcaatatata catatataga gagagtgcat atatatgtat     1800

atcgattagc tatctacaaa gtgcctattt tttagaagat ttttcattca ctcactcagt     1860

catgatcttg cagccataag agggtagata ttgagaagca gaaggctcaa gagagacaat     1920

tgcaatcgag cttcagattg tttactattt aagatgtact tttacaaagg aacaaagaag     1980

ggaaaaggta tttttgtttt tgttgtttgg tctgttatca tcaataacct gttcatatgc     2040

caattcagag aggtggactc caggttcagg agggagaaga gcaaagccgc ttcctctctg     2100

tgctttgaaa cttcacaccc tcacggtggc agctgtgtat ggaccagtgc cctccgcaga     2160

cagctcacaa aaccagttga ggtgcactaa agggacatga ggtagaatgg atgcttccat     2220

cacagtacca tcattcagaa taactcttcc aatttctgct ttcagacatg ctgcaggtcc     2280

tcatctgaac tgttgggttc gttttttttt ttttttttcc tgctccaaga aagtgacttc     2340

aaaaataact gatcaggata gattatttta ttttactttt taacactcct tctccccttt     2400

tcccactgaa ccaaaaagaa atcccatccc taaaacctgc cttctccttt tatgcaaaac     2460

tgaaaatggc aatacattat tatagccata atggtataga tagtgattgc gtttggctat     2520

gtgttgtttt cttttttttt aaattatgaa tatgtgtaaa atctgaggta acttgctaac     2580

gtgaatggtc atataacttt aaagatatat ttataattat ttaatgacat ttggaccctt     2640

gaaacatttc ttagtgtatt gatatgttga cttcggtctc taaaagtgct ctttattaaa     2700

taacaaattt cttcagtggt ctagagccat atctgaaata ttgctaagca atttcagttc     2760

atccaggcac aatgtgattt taaaaaatac ttccatctcc aaatatttta gatatagatt     2820

gtttttgtga tgtatgaagg aaatgttatg tttagttctt tcagatcttt gaatgcctct     2880

aacacagctt tgccttctaa agcggtaatt agggatttaa aaaacaacct ttagcccttt     2940

atcagcatga aatgctggag tgatgtggtt ttctaatttc tttggggtaa ttatgactct     3000

tgtcatatta aaaagacaag cacaagtaaa tcattgaact acagaaaaat gttctgtggt     3060

ttcatagtta agcaaaactc taaatcgcca ggcttcatag caaagacata gtcagctaaa     3120

agccgcacat gtggatagag ggttcaatta tgagacacct agtacaggag agcaaaattg     3180

caccagagat tcttaaccaa ccagccttac caaacaacac aacaggggaa ccccaatctg     3240

ccttacccaa ggccccactg gcagctttcc acagaatttg catttagagg agcagaatga     3300

catcactgtc ctttgggagt aggtcctctg aaaaggcagc aggttccagc aggtagctga     3360

gctgagagga catatggccc acggggacct acagacagcc tttgacattt gtatttctta     3420

caatggaggg ccaaggaggg caaggggctg tggagtttgg tgtctactag tgtgtatgaa     3480

tttgagctag agtccttctg tggcatgcac tttgaccact cctggcagtc acatggcaga     3540

tttccaagtg caaatcctta atccaaacaa ggatcatcta atgacaccac caggccaatc     3600

cctgctctcc tccccgaaaa gtcagggtcc cttcattgga atcctccacc cacccaagca     3660

gaatttagca gagatttgcc ttcaaaccct aacggccccc ttgttctctg gtccttctca     3720

aacccacctt tgtaggccac ccagcattgc aggacagcgt gtggggcagc tggacctgtg     3780

cttcctgcct gggagtctcc cttggaattc atcctgactc cttctaataa aaatggatgg     3840

gaaagcaaaa cactttgcct tctaaaggcc gtataccaag tatgcttaga taaataagcc     3900

acttttctat tacttaagta agaaggaagt agtaattgat actatttatt gtttgtgtgt     3960

ggtagcttga agcacaccac tgtccattta tttgtaagtg taaaatatgt gtgtttgttt     4020

cagcagcact taaaaaagcc agtgtctggt tacacatttc aattttaatt aattgacata     4080

aaaatgctac cgccagtgcc agctgcatcc tatttaatta aaaaggtact atatttgtac     4140

attatttttt aatgttaaaa gggctttttt aagtttacag tacacatacc gagtgacttt     4200

agggatgctt ttgtgttgaa atgttactat agtggctgca ggcagcaacc cagaaacact     4260

ttagaagctt tttttccttg ggaaaaattc aagcacttct tccctccacc ctcactccaa     4320

ccaccccaat gggggtaatt cacatttctt agaacaaatt ctgccctttt ttggtctagg     4380

gattaaaatt ttgtttttct ttctttcttt tttttttttt ttcactgaac ccttaatttg     4440

cactgggtca tgtgtttgat ttgtgatttc aagaccaaag caaagtctta ctactactgt     4500

ggaaccatgt actagttcct gggaattaaa atagcgtggt tctctttgta gcacaaacat     4560

tgctggaatt tgcagtcttt tcaatgcagc cacattttta tccatttcag ttgtctcaca     4620

aattttaacc catatcagag ttccagaaca ggtaccacag ctttggtttt agattagtgg     4680

aataacattc agcccagaac tgagaaactc aacagattaa ctatcgtttg ctctttagac     4740

ggtctcactg cctctcactt gccagagccc tttcaaaatg agcagagaag tccacaccat     4800

tagggaccat ctgtgataaa ttcagaaggg aggagatgtg tgtacagctt taaggattcc     4860

ctcaattccg aggaaaggga ctggcccaga atccaggtta atacatggaa acacgaagca     4920

ttagcaaaag taataattat acctatggta tttgaaagaa caataataaa agacacttct     4980

tccaaacctt gaatttgttg tttttagaaa acgaatgcat ttaaaaatat tttctatgtg     5040

agaatttttt agatgtgtgt ttacttcatg tttacaaata actgtttgct ttttaatgca     5100

gtactttgaa atatatcagc caaaaccata acttacaata atttcttagg tattctgaat     5160

aaaattccat ttcttttgga tatgctttac cattcttagg tttctgtgga acaaaaatat     5220

ttgtagcatt ttgtgtaaat acaagctttc atttttattt tttccaattg ctattgccca     5280

agaattgctt tccatgcaca tattgtaaaa attccgcttt gtgccacagg tcatgattgt     5340

ggatgagttt actcttaact tcaaagggac tatttgtatt gtatgttgca actgtaaatt     5400

gaattatttg gcatttttct catgattgta atattaattt gaagtttgaa tttaattttc     5460

aataaaatgg cttttttggt tttgtta                                         5487


<210>  16
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro 
1               5                   10                  15      


Ser Ser Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val 
            20                  25                  30          


Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg 
65                  70                  75                  80  


Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr 
                85                  90                  95      


Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys 
            100                 105                 110         


Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala Leu Gly Glu Val 
        115                 120                 125             


Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr 
    130                 135                 140                 


Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala 
145                 150                 155                 160 


Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
                165                 170         


<210>  17
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Asp Phe Gln Val Gln Ile Leu Asn Pro Asn Lys Asp His Leu 
1               5                   10                  15      


Met Thr Pro Pro Gly Gln Ser Leu Leu Ser Ser Pro Lys Ser Gln Gly 
            20                  25                  30          


Pro Phe Ile Gly Ile Leu His Pro Pro Lys Gln Asn Leu Ala Glu Ile 
        35                  40                  45              


Cys Leu Gln Thr Leu Thr Ala Pro Leu Phe Ser Gly Pro Ser Gln Thr 
    50                  55                  60                  


His Leu Cys Arg Pro Pro Ser Ile Ala Gly Gln Arg Val Gly Gln Leu 
65                  70                  75                  80  


Asp Leu Cys Phe Leu Pro Gly Ser Leu Pro Trp Asn Ser Ser 
                85                  90                  


<210>  18
<211>  2746
<212>  DNA
<213>  Homo sapiens

<400>  18
ggctccgact tggactccct gctccgctgc tgccgcttcg gccccgcacg cagccagccg       60

ccagccgccc gcccggccca gctcccgccg cggccccttg ccgcggtccc tctcctggtc      120

ccctcccggt tggtccgggg gtgcgcaggg ggcagggcgg gcgcccaggg gaagctcgag      180

ggacgcgcgc gcgaaggctc ctttgtggac ttcacggccg ccaacatctg ggcgcagcgc      240

gggccaccgc tggccgtctc gccgccgcgt cgccttgggg acccgagggg gctcagcccc      300

aaggacggag acttcgattc gggaccagcc ccccgggatg cggtagcggc cgctgtgcgg      360

aggccgcgaa gcagctgcag ccgccgccgc gcagatccac gctggctccg tgcgccatgg      420

tcacccacag caagtttccc gccgccggga tgagccgccc cctggacacc agcctgcgcc      480

tcaagacctt cagctccaag agcgagtacc agctggtggt gaacgcagtg cgcaagctgc      540

aggagagcgg cttctactgg agcgcagtga ccggcggcga ggcgaacctg ctgctcagtg      600

ccgagcccgc cggcaccttt ctgatccgcg acagctcgga ccagcgccac ttcttcacgc      660

tcagcgtcaa gacccagtct gggaccaaga acctgcgcat ccagtgtgag gggggcagct      720

tctctctgca gagcgatccc cggagcacgc agcccgtgcc ccgcttcgac tgcgtgctca      780

agctggtgca ccactacatg ccgccccctg gagccccctc cttcccctcg ccacctactg      840

aaccctcctc cgaggtgccc gagcagccgt ctgcccagcc actccctggg agtcccccca      900

gaagagccta ttacatctac tccgggggcg agaagatccc cctggtgttg agccggcccc      960

tctcctccaa cgtggccact cttcagcatc tctgtcggaa gaccgtcaac ggccacctgg     1020

actcctatga gaaagtcacc cagctgccgg ggcccattcg ggagttcctg gaccagtacg     1080

atgccccgct ttaaggggta aagggcgcaa agggcatggg tcgggagagg ggacgcaggc     1140

ccctctcctc cgtggcacat ggcacaagca caagaagcca accaggagag agtcctgtag     1200

ctctgggggg aaagagggcg gacaggcccc tccctctgcc ctctccctgc agaatgtggc     1260

aggcggacct ggaatgtgtt ggagggaagg gggagtacca cctgagtctc cagcttctcc     1320

ggaggagcca gctgtcctgg tgggacgata gcaaccacaa gtggattctc cttcaattcc     1380

tcagcttccc ctctgcctcc aaacagggga cacttcggga atgctgaact aatgagaact     1440

gccagggaat cttcaaactt tccaacggaa cttgtttgct ctttgatttg gtttaaacct     1500

gagctggttg tggagcctgg gaaaggtgga agagagagag gtcctgaggg ccccagggct     1560

gcgggctggc gaaggaaatg gtcacacccc ccgcccaccc caggcgagga tcctggtgac     1620

atgctcctct ccctggctcc ggggagaagg gcttggggtg acctgaaggg aaccatcctg     1680

gtaccccaca tcctctcctc cgggacagtc accgaaaaca caggttccaa agtctacctg     1740

gtgcctgaga gcccagggcc cttcctccgt tttaaggggg aagcaacatt tggaggggat     1800

ggatgggctg gtcagctggt ctccttttcc tactcatact ataccttcct gtacctgggt     1860

ggatggagcg ggaggatgga ggagacggga catctttcac ctcaggctcc tggtagagaa     1920

gacaggggat tctactctgt gcctcctgac tatgtctggc taagagattc gccttaaatg     1980

ctccctgtcc catggagagg gacccagcat aggaaagcca catactcagc ctggatgggt     2040

ggagaggctg agggactcac tggagggcac caagccagcc cacagccagg gaagtgggga     2100

gggggggcgg aaacccatgc ctcccagctg agcactggga atgtcagccc agtaagtatt     2160

ggccagtcag gcgcctcgtg gtcagagcag agccaccagg tcccactgcc ccgagccctg     2220

cacagccctc cctcctgcct gggtggggga ggctggaggt cattggagag gctggactgc     2280

tgccaccccg ggtgctcccg ctctgccata gcactgatca gtgacaattt acaggaatgt     2340

agcagcgatg gaattacctg gaacagtttt ttgtttttgt ttttgttttt gtttttgtgg     2400

gggggggcaa ctaaacaaac acaaagtatt ctgtgtcagg tattgggctg gacagggcag     2460

ttgtgtgttg gggtggtttt tttctctatt tttttgtttg tttcttgttt tttaataatg     2520

tttacaatct gcctcaatca ctctgtcttt tataaagatt ccacctccag tcctctctcc     2580

tcccccctac tcaggccctt gaggctatta ggagatgctt gaagaactca acaaaatccc     2640

aatccaagtc aaactttgca catatttata tttatattca gaaaagaaac atttcagtaa     2700

tttataataa agagcactat tttttaatga aaaaaaaaaa aaaaaa                    2746


<210>  19
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210>  20
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  20
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gagatgttac agcccagata gctcttcagc ctgcactgaa      420

gttcaatggt ggtggtcata tcaatcatag cattttctgg acaaacctca gccctaacgg      480

tggtggagaa cccaaagggg agttgctgga agccatcaaa cgtgactttg gttcctttga      540

caagtttaag gagaagctga cggctgcatc tgttggtgtc caaggctcag gttggggttg      600

gcttggtttc aataaggaac ggggacactt acaaattgct gcttgtccaa atcaggatcc      660

actgcaagga acaacaggcc ttattccact gctggggatt gatgtgtggg agcacgctta      720

ctaccttcag tataaaaatg tcaggcctga ttatctaaaa gctatttgga atgtaatcaa      780

ctgggagaat gtaactgaaa gatacatggc ttgcaaaaag taaaccacga tcgttatgct      840

gagtatgtta agctctttat gactgttttt gtagtggtat agagtactgc agaatacagt      900

aagctgctct attgtagcat ttcttgatgt tgcttagtca cttatttcat aaacaactta      960

atgttctgaa taatttctta ctaaacattt tgttattggg caagtgattg aaaatagtaa     1020

atgctttgtg tgattgaatc tgattggaca ttttcttcag agagctaaat tacaattgtc     1080

atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt     1140

tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa     1200

taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt     1260

gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt     1320

caaatgttcc tgtatagttt ttgcaaatag agctgtatac tgtttaaatg tagcaggtga     1380

actgaactgg ggtttgctca cctgcacagt aaaggcaaac ttcaacagca aaactgcaaa     1440

aaggtggttt ttgcagtagg agaaaggagg atgtttattt gcagggcgcc aagcaaggag     1500

aattgggcag ctcatgcttg agacccaatc tccatgatga cctacaagct agagtattta     1560

aaggcagtgg taaatttcag gaaagcagaa gtt                                  1593


<210>  21
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Arg Phe Gln Ala 
65                  70                  75                  80  


Glu Arg Arg Glu Ala Val Pro Gly Arg Gly Asp Pro Arg Glu Pro Gly 
                85                  90                  95      


Pro Ile Arg Thr Gly Leu Ser Val Glu Glu Asn Ser Leu Arg Ile Cys 
            100                 105                 110         


Thr Gly Ser Glu Phe Ser Arg His Asp Ser Leu Ser Phe Lys His Met 
        115                 120                 125             


Val Tyr Leu Ile Val Glu Gly Val Pro Arg Trp Val 
    130                 135                 140 


<210>  22
<211>  1646
<212>  DNA
<213>  Homo sapiens

<400>  22
cactgcgaag cccagctgcg cgcgccttgg gattgactgt ccacgctcgc ccggctcgtc       60

cgacgcgccc tccgccagcc gacagacaca gccgcacgca ctgccgtgtt ctccctgcgg      120

ctcggacaca tagtatgacc attaggtgtt tcgtctccca cccattttct atggaaaacc      180

aaggggatcg ggccatgata gccactggca gctttgaaga acgggacacc tttagagaag      240

cttgatcttg gaggcctcac cgtgagacct tacaaagccg gattccggca gagttcctct      300

atctcgtctt gttgctgatt aaaggtgccc ctgtctccag tttttctcca tctcctggga      360

cgtagcagga aatcagcatc atggttgggt tcaaggccac agatgtgccc cctactgcca      420

ctgtgaagtt tcttggggct ggcacagctg cctgcatcgc agatctcatc acctttcctc      480

tggatactgc taaagtccgg ttacagatcc aaggagaaag tcaggggcca gtgcgcgcta      540

cagccagcgc ccagtaccgc ggtgtgatgg gcaccattct gaccatggtg cgtactgagg      600

gcccccgaag cctctacaat gggctggttg ccggcctgca gcgccaaatg agctttgcct      660

ctgtccgcat cggcctgtat gattctgtca aacagttcta caccaagggc tctgagcatg      720

ccagcattgg gagccgcctc ctagcaggca gcaccacagg tgccctggct gtggctgtgg      780

cccagcccac ggatgtggta aaggtccgat tccaagctca ggcccgggct ggaggtggtc      840

ggagatacca aagcaccgtc aatgcctaca agaccattgc ccgagaggaa gggttccggg      900

gcctctggaa agggacctct cccaatgttg ctcgtaatgc cattgtcaac tgtgctgagc      960

tggtgaccta tgacctcatc aaggatgccc tcctgaaagc caacctcatg acagatgacc     1020

tcccttgcca cttcacttct gcctttgggg caggcttctg caccactgtc atcgcctccc     1080

ctgtagacgt ggtcaagacg agatacatga actctgccct gggccagtac agtagcgctg     1140

gccactgtgc ccttaccatg ctccagaagg aggggccccg agccttctac aaagggttca     1200

tgccctcctt tctccgcttg ggttcctgga acgtggtgat gttcgtcacc tatgagcagc     1260

tgaaacgagc cctcatggct gcctgcactt cccgagaggc tcccttctga gcctctcctg     1320

ctgctgacct gatcacctct ggctttgtct ctagccgggc catgctttcc ttttcttcct     1380

tctttctctt ccctccttcc cttctctcct tccctctttc cccacctctt ccttccgctc     1440

ctttacctac caccttccct ctttctacat tctcatctac tcattgtctc agtgctggtg     1500

gagttgacat ttgacagtgt gggaggcctc gtaccagcca ggatcccaag cgtcccgtcc     1560

cttggaaagt tcagccagaa tcttcgtcct gcccccgaca gcccagccta gcccacttgt     1620

catccataaa gcaagctcaa ccttgg                                          1646


<210>  23
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Val Gly Phe Lys Ala Thr Asp Val Pro Pro Thr Ala Thr Val Lys 
1               5                   10                  15      


Phe Leu Gly Ala Gly Thr Ala Ala Cys Ile Ala Asp Leu Ile Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Ser Gln 
        35                  40                  45              


Gly Pro Val Arg Ala Thr Ala Ser Ala Gln Tyr Arg Gly Val Met Gly 
    50                  55                  60                  


Thr Ile Leu Thr Met Val Arg Thr Glu Gly Pro Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Gly Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Val Arg 
                85                  90                  95      


Ile Gly Leu Tyr Asp Ser Val Lys Gln Phe Tyr Thr Lys Gly Ser Glu 
            100                 105                 110         


His Ala Ser Ile Gly Ser Arg Leu Leu Ala Gly Ser Thr Thr Gly Ala 
        115                 120                 125             


Leu Ala Val Ala Val Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
    130                 135                 140                 


Gln Ala Gln Ala Arg Ala Gly Gly Gly Arg Arg Tyr Gln Ser Thr Val 
145                 150                 155                 160 


Asn Ala Tyr Lys Thr Ile Ala Arg Glu Glu Gly Phe Arg Gly Leu Trp 
                165                 170                 175     


Lys Gly Thr Ser Pro Asn Val Ala Arg Asn Ala Ile Val Asn Cys Ala 
            180                 185                 190         


Glu Leu Val Thr Tyr Asp Leu Ile Lys Asp Ala Leu Leu Lys Ala Asn 
        195                 200                 205             


Leu Met Thr Asp Asp Leu Pro Cys His Phe Thr Ser Ala Phe Gly Ala 
    210                 215                 220                 


Gly Phe Cys Thr Thr Val Ile Ala Ser Pro Val Asp Val Val Lys Thr 
225                 230                 235                 240 


Arg Tyr Met Asn Ser Ala Leu Gly Gln Tyr Ser Ser Ala Gly His Cys 
                245                 250                 255     


Ala Leu Thr Met Leu Gln Lys Glu Gly Pro Arg Ala Phe Tyr Lys Gly 
            260                 265                 270         


Phe Met Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val Val Met Phe 
        275                 280                 285             


Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Ala Ala Cys Thr Ser 
    290                 295                 300                 


Arg Glu Ala Pro Phe 
305                 


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ggtcacgccg atccatataa g                                                 21


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
tctgtgtgtg tacgagctca tga                                               23


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ggactcccct cacaagttct tacat                                             25


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gtgacataca tgcgtttgag gaa                                               23


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
tccatgcgcg gagagtct                                                     18


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
gggcggagag gaatttcag                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
ccctttccaa atcctcagca t                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
cctggcgtcg tgattagtga                                                   20


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
tgcaacgcgg gcaaa                                                        15


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
tttagtgatg tgggaggatc ttca                                              24


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
agtcccccca cctacaactc a                                                 21


<210>  35
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
gagtgtaata gctcacgttg gagaaa                                            26


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
tccggagcgg gaagaact                                                     18


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
tcaaatcatc aacactgcct caa                                               23


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
cccgaggtcc atctactgta actt                                              24


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
agtagcaagg ttcaacgatc tgaga                                             25


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
ctaccaccac tgcatcaaat tcat                                              24


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
ggaacaagag ggcatctgct a                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
tggaagccat caaacgtgac t                                                 21


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
tttgtaagtg tccccgttcc tt                                                22


<210>  44
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
ggagctgtga tgtgaagttt cctata                                            26


<210>  45
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
ccagaaacaa aaataaggag aacaattc                                          28


<210>  46
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
cctctatctc gtcttgttgc tgatta                                            26


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
cgtcccagga gatggagaaa                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
ttgatcccca atgcttcaca                                                   20


<210>  49
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
cggcaacctc agccaagt                                                     18


