                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc.
       Massachusetts Institute of Technology
       Pridgen, Eric M
       Alexis, Frank
       Langer, Robert  S
       Farokhzad, Omid C
 
<120>  RECEPTOR-TARGETED NANOPARTICLES FOR ENHANCED TRANSCYTOSIS 
       MEDIATED DRUG DELIVERY

<130>  BWH 22454 PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  2
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  2

Glx Val Gln Leu Glu Gln Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Ser Phe Asp Asp Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Phe Tyr Thr Gly Thr Thr Leu Leu Asp Pro Ser Leu Arg 
    50                  55                  60                  


Gly Arg Val Thr Met Leu Val Asn Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Leu Ile Ala Gly Gly Ile Asp Val Trp Gly Gln Gly Ser Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  3
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  3
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag ggtctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa atga                                             684


<210>  4
<211>  689
<212>  DNA
<213>  Homo sapiens

<400>  4
gtggagtgcc caccttgccc agcaccacct gtggcaggac cttcagtctt cctcttcccc       60

ccaaaaccca aggacaccct gatgatctcc agaacccctg aggtcacgtg cgtggtggtg      120

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg catggaggtg      180

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc      240

gtcctcaccg tcgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc      300

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga      360

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc      420

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat      480

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc      540

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      600

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct      660

ccgggtaaat gagtgccacg gctagctgg                                        689


<210>  5
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  5
gacacacctc ccccgtgccc aaggtgccca gcacctgaac tcctgggagg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggatacc cttatgattt cccggacccc tgaggtcacg      120

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaagtg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgttc      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaaaccaaa      360

ggacagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      480

tgggagagca gcgggcagcc ggagaacaac tacaacacca cgcctcccat gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacatcttct catgctccgt gatgcatgag gctctgcaca accgcttcac gcagaagagc      660

ctctccctgt ctccgggtaa atga                                             684


<210>  6
<211>  674
<212>  DNA
<213>  Homo sapiens

<400>  6
cccccatgcc catcatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc       60

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      120

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      180

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      240

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      300

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc      360

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc      420

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc      480

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      540

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc      600

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg      660

tctccgggta aatg                                                        674


