                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Organophosphorous hydrolase variants

<130>  12753-WO-PCT

<160>  288   

<170>  PatentIn version 3.5

<210>  1
<211>  996
<212>  DNA
<213>  Aplysia californica


<220>
<221>  CDS
<222>  (1)..(993)

<400>  1
atg gca cat cac cac cac cat cac gtg ggt acc ggt tcg aat gat gac         48
Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp           
1               5                   10                  15                

gac gac aag agt ccg gat ccc gca cct acg gtt gta tct ctt cag ttt         96
Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe           
            20                  25                  30                    

agc aaa atc atc gac gac gtt tca ggc gct gaa ggc cct gta ttc gac        144
Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp           
        35                  40                  45                        

agc aac ggt act ttc tac gtt gta gct cct ggt gta cgc aaa gac gct        192
Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala           
    50                  55                  60                            

aaa cct gct ggc caa gtt gta cgc atc gac ctt tca tca ggt cag aaa        240
Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys           
65                  70                  75                  80            

aca gtt ctt tgc gag cct caa gta aac ggt gac gga ggc atc cct tgc        288
Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys           
                85                  90                  95                

ggc tgc caa gct gac aaa caa ggc aac ctt tac gtt gct gac atg cgc        336
Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg           
            100                 105                 110                   

ctt ggt atc ctt aaa gta aaa cca aac ggc gag ttc act caa gtt gct        384
Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala           
        115                 120                 125                       

cgc gta gac gaa ggt ggt cgc aca atg caa ggc tgc aac gac tgc tct        432
Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser           
    130                 135                 140                           

ctt gac tat aca ggc aac ctt tgg gta act gcg cct gct ggc gac atc        480
Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile           
145                 150                 155                 160           

gct cct tct gag ttc aaa atg tct ttt cag gag tct atc ggt tca atc        528
Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile           
                165                 170                 175               

tat tgc ctt aca tct gag ggt aaa gta gta cat ctt gac act ggt ctt        576
Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu           
            180                 185                 190                   

cgc ttc cct aac ggc atc gct gtt atc cat gac gct aat cgt cgc cct        624
Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro           
        195                 200                 205                       

gtt aaa ctt atc gta gcg gag aca cct aca cgc ctt ctt ctt gct tac        672
Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr           
    210                 215                 220                           

gac atc caa ggc cct ggt ctt gta gcg aac aaa act aaa tgg gct aaa        720
Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys           
225                 230                 235                 240           

ctt cct gac tgc gag caa gaa ggt ggc cct gac ggt atg gac ttc gac        768
Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp           
                245                 250                 255               

gac gca ggt aac ctt ctt gtt gct cac tgg ggt gct ggt cat atc gag        816
Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu           
            260                 265                 270                   

gtt ttt ggt cct gat ggc ggt gag cct atc aaa cgc atc aaa tgt cca        864
Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro           
        275                 280                 285                       

ttt gac aaa cct agc aac gta cac ttc gag cct aac tct aac atc gtt        912
Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val           
    290                 295                 300                           

tac gta act gag cat acg aac aac gct ctt tgg aaa ttc caa tgg gag        960
Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu           
305                 310                 315                 320           

aac aaa ggc atg cct cag tat tgt gac aaa aac taa                        996
Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn                               
                325                 330                                   


<210>  2
<211>  331
<212>  PRT
<213>  Aplysia californica

<400>  2

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  3
<211>  930
<212>  DNA
<213>  Aplysia californica


<220>
<221>  CDS
<222>  (1)..(927)

<400>  3
atg gct ccc aca gtc gtc tct cta cag ttt tca aaa att att gac gat         48
Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp           
1               5                   10                  15                

gta tca gga gca gaa ggc cca gtg ttt gac agt aac ggc act ttt tat         96
Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr           
            20                  25                  30                    

gtt gtt gct cct gga gta aga aaa gat gca aag ccg gct ggt cag gtc        144
Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val           
        35                  40                  45                        

gtc cga att gac ctg agc tca gga cag aaa act gtt ttg tgt gag cct        192
Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro           
    50                  55                  60                            

cag gtt aac ggt gat ggg gga att ccg tgt ggt tgc caa gct gac aag        240
Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys           
65                  70                  75                  80            

cag ggc aac tta tat gtc gct gac atg agg ctg gga atc ttg aaa gtc        288
Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val           
                85                  90                  95                

aaa cct aat gga gaa ttc acg cag gtg gca aga gta gac gag gga gga        336
Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly           
            100                 105                 110                   

agg acc atg cag ggc tgt aat gac tgt agc ctc gac tat acc ggg aac        384
Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn           
        115                 120                 125                       

ctg tgg gtc acg gca cca gct ggt gac ata gcc ccg agt gaa ttc aag        432
Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys           
    130                 135                 140                           

atg tcg ttt cag gaa agt att ggt tcg att tac tgc ttg act tca gag        480
Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu           
145                 150                 155                 160           

gga aaa gtg gtt cat ttg gac aca ggg ctc aga ttc cca aac ggt ata        528
Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile           
                165                 170                 175               

gct gtc att cat gac gca aac agg cgg ccg gta aag ctc ata gtg gca        576
Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala           
            180                 185                 190                   

gaa acg ccg acg cga ctc ctc ttg gcc tat gac att caa gga cct gga        624
Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly           
        195                 200                 205                       

tta gtc gct aat aaa acg aaa tgg gcc aaa ttg cca gat tgt gag caa        672
Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln           
    210                 215                 220                           

gaa ggt ggc cca gat gga atg gac ttt gac gat gcg gga aat ttg ctg        720
Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu           
225                 230                 235                 240           

gtg gct cac tgg ggt gcc ggg cac atc gaa gtg ttt ggt ccg gac gga        768
Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly           
                245                 250                 255               

ggc gaa ccg atc aag cgt atc aag tgt cct ttt gac aag ccg agc aat        816
Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn           
            260                 265                 270                   

gtg cat ttt gag cca aac tcc aac atc gtg tac gtg acg gag cac acg        864
Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr           
        275                 280                 285                       

aac aac gcc cta tgg aag ttc cag tgg gag aac aag ggc atg cct cag        912
Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln           
    290                 295                 300                           

tat tgt gac aaa aac tga                                                930
Tyr Cys Asp Lys Asn                                                       
305                                                                       


<210>  4
<211>  309
<212>  PRT
<213>  Aplysia californica

<400>  4

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  5
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  5

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Ile Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  6
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  6

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Phe Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  7
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  7

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Ala 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  8
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  8

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Gln Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  9
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  9

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Ser Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  10
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  10

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Gln Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  11
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  11

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Thr Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  12
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  12

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Tyr Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  13
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  13

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Trp Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  14
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  14

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Ala Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  15
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  15

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Val Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  16
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  16

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Gly Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  17
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  17

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Ala Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  18
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  18

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Ala Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  19
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  19

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Val Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  20
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  20

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ala Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  21
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  21

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Gly 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  22
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  22

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Gly Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  23
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  23

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Pro Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  24
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  24

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Thr Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  25
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  25

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Ala Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  26
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  26

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Val Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  27
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  27

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Gly Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  28
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  28

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ile Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  29
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  29

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Ser Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  30
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  30

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Gly Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  31
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  31

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  32
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  32

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Met Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  33
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  33

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Met Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  34
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  34

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Leu Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  35
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  35

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Ala Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  36
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  36

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Trp Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  37
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  37

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Met Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  38
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  38

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  39
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  39

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Ser Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  40
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  40

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Val Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  41
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  41

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Val Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  42
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  42

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Ala Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  43
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  43

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Trp Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  44
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  44

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ser Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  45
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  45

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  46
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  46

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Pro Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  47
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  47

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Asn Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  48
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  48

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Phe Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  49
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  49

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Ile Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  50
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  50

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ile Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  51
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  51

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Val Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  52
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  52

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ala Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  53
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  53

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Val Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  54
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  54

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ser Lys Met Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  55
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  55

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Gly Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  56
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  56

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  57
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  57

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Ala Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  58
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  58

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Ile Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  59
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  59

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Ala Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  60
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  60

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Met Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  61
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  61

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asn Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  62
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  62

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Ser Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  63
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  63

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asn Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  64
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  64

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Ala Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  65
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  65

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Pro Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  66
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  66

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Ala Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  67
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  67

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  68
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  68

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ala Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  69
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  69

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Ser Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  70
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  70

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Thr Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  71
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  71

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Thr Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  72
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  72

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Ser Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  73
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  73

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Glu Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  74
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  74

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Ser Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  75
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  75

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Thr Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  76
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  76

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asn Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  77
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  77

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ser Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  78
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  78

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Thr Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  79
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  79

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Ala Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  80
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  80

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Ala Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  81
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  81

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Gln Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  82
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  82

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Ala Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  83
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  83

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Thr Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  84
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  84

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Glu Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  85
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  85

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asn Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  86
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  86

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Asp Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  87
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  87

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Gln Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  88
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  88

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Thr Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  89
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  89

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Ala Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  90
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  90

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asn Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  91
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  91

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Gln Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  92
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  92

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Ser Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  93
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  93

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Lys Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  94
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  94

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Arg Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  95
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  95

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Ala Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  96
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  96

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Glu Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  97
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  97

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Asn Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  98
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  98

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Asp Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  99
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  99

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Glu Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  100
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  100

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Ala Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  101
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  101

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Gln Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  102
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  102

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Gly Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  103
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  103

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asn Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  104
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  104

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Gln Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  105
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  105

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Asp Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  106
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  106

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Ala Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  107
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  107

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Asn Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  108
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  108

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Ala Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  109
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  109

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  110
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  110

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Gln Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  111
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  111

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  112
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  112

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Val Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  113
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  113

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Phe Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  114
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  114

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Pro Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  115
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  115

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Phe Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  116
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  116

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  117
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  117

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Asn Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  118
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  118

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Gln Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  119
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  119

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Gln Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  120
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  120

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Val Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  121
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  121

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Pro Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  122
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  122

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Ser Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  123
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  123

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Asp Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  124
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  124

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Arg Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Thr Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  125
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  125

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  126
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  126

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Ile Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  127
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  127

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Asp Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  128
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  128

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Val Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  129
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  129

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Ser Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  130
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  130

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Pro Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  131
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  131

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  132
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  132

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Ala Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  133
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  133

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Val Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  134
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  134

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Met Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  135
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  135

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ala Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  136
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  136

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Gly 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  137
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  137

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Ile Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  138
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  138

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Met Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  139
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  139

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Ala Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  140
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  140

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Thr Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  141
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  141

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Ser Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  142
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  142

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Thr Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  143
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  143

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Leu Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  144
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  144

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Val Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  145
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  145

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Ala Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Cys 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  146
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  146

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Pro Thr Val Val Ser Leu Gln Phe 
            20                  25                  30          


Ser Lys Ile Ile Asp Asp Val Ser Gly Ala Glu Gly Pro Val Phe Asp 
        35                  40                  45              


Ser Asn Gly Thr Phe Tyr Val Val Ala Pro Gly Val Leu Lys Asp Ala 
    50                  55                  60                  


Lys Pro Ala Gly Gln Val Val Arg Ile Asp Leu Ser Ser Gly Gln Lys 
65                  70                  75                  80  


Thr Val Leu Cys Glu Pro Gln Val Asn Gly Asp Gly Gly Ile Pro Ala 
                85                  90                  95      


Gly Cys Gln Ala Asp Lys Gln Gly Asn Leu Tyr Val Ala Asp Met Arg 
            100                 105                 110         


Leu Gly Ile Leu Lys Val Lys Pro Asn Gly Glu Phe Thr Gln Val Ala 
        115                 120                 125             


Arg Val Asp Glu Gly Gly Arg Thr Met Gln Gly Cys Asn Asp Cys Ser 
    130                 135                 140                 


Leu Asp Tyr Thr Gly Asn Leu Trp Val Thr Ala Pro Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Pro Ser Glu Phe Lys Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile 
                165                 170                 175     


Tyr Cys Leu Thr Ser Glu Gly Lys Val Val His Leu Asp Thr Gly Leu 
            180                 185                 190         


Arg Phe Pro Asn Gly Ile Ala Val Ile His Asp Ala Asn Arg Arg Pro 
        195                 200                 205             


Val Lys Leu Ile Val Ala Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr 
    210                 215                 220                 


Asp Ile Gln Gly Pro Gly Leu Val Ala Asn Lys Thr Lys Trp Ala Lys 
225                 230                 235                 240 


Leu Pro Asp Cys Glu Gln Glu Gly Gly Gly Asp Gly Met Asp Phe Asp 
                245                 250                 255     


Asp Ala Gly Asn Leu Leu Val Ala His Trp Gly Ala Gly His Ile Glu 
            260                 265                 270         


Val Phe Gly Pro Asp Gly Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro 
        275                 280                 285             


Phe Asp Lys Pro Ser Asn Val His Phe Glu Pro Asn Ser Asn Ile Val 
    290                 295                 300                 


Tyr Val Thr Glu His Thr Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu 
305                 310                 315                 320 


Asn Lys Gly Met Pro Gln Tyr Cys Asp Lys Asn 
                325                 330     


<210>  147
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  147

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Ile Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  148
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  148

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Phe Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  149
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  149

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Ala Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  150
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  150

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Gln Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  151
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  151

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Ser 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  152
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  152

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Gln Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  153
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  153

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Thr Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  154
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  154

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Tyr Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  155
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  155

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Trp Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  156
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  156

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Ala Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  157
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  157

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Val Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  158
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  158

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Gly Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  159
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  159

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Ala Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  160
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  160

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Ala Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  161
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  161

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Val Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  162
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  162

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ala Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  163
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  163

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Gly Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  164
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  164

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Gly Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  165
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  165

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Pro Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  166
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  166

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Thr Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  167
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  167

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Ala Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  168
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  168

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Val Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  169
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  169

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Gly Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  170
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  170

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ile Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  171
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  171

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Ser Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  172
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  172

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Gly Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  173
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  173

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  174
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  174

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Met Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  175
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  175

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Met Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  176
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  176

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Leu Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  177
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  177

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Ala Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  178
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  178

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Trp Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  179
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  179

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Met Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  180
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  180

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  181
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  181

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Ser Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  182
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  182

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Val Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  183
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  183

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Val Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  184
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  184

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Ala Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  185
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  185

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Trp Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  186
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  186

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ser Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  187
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  187

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  188
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  188

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Pro Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  189
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  189

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Asn Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  190
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  190

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Phe Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  191
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  191

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Ile Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  192
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  192

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ile Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  193
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  193

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Val Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  194
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  194

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ala Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  195
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  195

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Val Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  196
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  196

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ser Lys 
    130                 135                 140                 


Met Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  197
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  197

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Gly Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  198
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  198

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  199
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  199

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Ala 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  200
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  200

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Ile Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  201
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  201

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Ala Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  202
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  202

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Met Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  203
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  203

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asn Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  204
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  204

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Ser Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  205
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  205

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asn Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  206
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  206

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Ala Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  207
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  207

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Pro Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  208
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  208

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Ala Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  209
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  209

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  210
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  210

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ala Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  211
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  211

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Ser Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  212
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  212

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Thr Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  213
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  213

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Thr Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  214
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  214

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Ser 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  215
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  215

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Glu Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  216
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  216

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Ser Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  217
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  217

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Thr 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  218
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  218

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asn Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  219
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  219

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ser Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  220
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  220

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Thr Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  221
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  221

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Ala Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  222
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  222

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Ala 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  223
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  223

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Gln Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  224
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  224

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Ala Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  225
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  225

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Thr 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  226
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  226

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Glu 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  227
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  227

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asn 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  228
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  228

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Asp Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  229
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  229

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Gln Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  230
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  230

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Thr Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  231
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  231

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Ala Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  232
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  232

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asn Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  233
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  233

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Gln Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  234
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  234

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Ser 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  235
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  235

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Lys Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  236
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  236

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Arg Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  237
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  237

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Ala Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  238
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  238

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Glu Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  239
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  239

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Asn Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  240
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  240

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Asp Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  241
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  241

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Glu Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  242
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  242

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Ala Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  243
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  243

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Gln Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  244
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  244

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Gly Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  245
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  245

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asn Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  246
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  246

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Gln Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  247
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  247

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Asp Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  248
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  248

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Ala Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  249
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  249

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Asn Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  250
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  250

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Ala Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  251
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  251

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  252
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  252

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Gln Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  253
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  253

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  254
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  254

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Val Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  255
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  255

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Phe Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  256
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  256

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Pro Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  257
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  257

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Phe Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  258
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  258

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  259
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  259

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Asn Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  260
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  260

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Gln Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  261
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  261

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Gln Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  262
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  262

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Val Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  263
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  263

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Pro Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  264
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  264

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Ser 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  265
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  265

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Asp Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  266
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  266

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Arg Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Thr Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  267
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  267

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  268
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  268

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Ile Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  269
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  269

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Asp Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  270
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  270

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Val Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  271
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  271

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Ser Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  272
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  272

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Pro Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  273
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  273

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asp Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  274
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  274

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Ala Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  275
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  275

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Val Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  276
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  276

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Met Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  277
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  277

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ala Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  278
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  278

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Gly Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  279
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  279

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Ile Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  280
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  280

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Met Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  281
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  281

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Ala Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  282
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  282

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Thr Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  283
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  283

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Ser Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  284
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  284

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Thr Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  285
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  285

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Leu Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  286
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  286

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Val Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  287
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  287

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Ala Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Cys Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


<210>  288
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic variant

<400>  288

Met Ala Pro Thr Val Val Ser Leu Gln Phe Ser Lys Ile Ile Asp Asp 
1               5                   10                  15      


Val Ser Gly Ala Glu Gly Pro Val Phe Asp Ser Asn Gly Thr Phe Tyr 
            20                  25                  30          


Val Val Ala Pro Gly Val Leu Lys Asp Ala Lys Pro Ala Gly Gln Val 
        35                  40                  45              


Val Arg Ile Asp Leu Ser Ser Gly Gln Lys Thr Val Leu Cys Glu Pro 
    50                  55                  60                  


Gln Val Asn Gly Asp Gly Gly Ile Pro Ala Gly Cys Gln Ala Asp Lys 
65                  70                  75                  80  


Gln Gly Asn Leu Tyr Val Ala Asp Met Arg Leu Gly Ile Leu Lys Val 
                85                  90                  95      


Lys Pro Asn Gly Glu Phe Thr Gln Val Ala Arg Val Asp Glu Gly Gly 
            100                 105                 110         


Arg Thr Met Gln Gly Cys Asn Asp Cys Ser Leu Asp Tyr Thr Gly Asn 
        115                 120                 125             


Leu Trp Val Thr Ala Pro Ala Gly Asp Ile Ala Pro Ser Glu Phe Lys 
    130                 135                 140                 


Ala Ser Phe Gln Glu Ser Ile Gly Ser Ile Tyr Cys Leu Thr Ser Glu 
145                 150                 155                 160 


Gly Lys Val Val His Leu Asp Thr Gly Leu Arg Phe Pro Asn Gly Ile 
                165                 170                 175     


Ala Val Ile His Asp Ala Asn Arg Arg Pro Val Lys Leu Ile Val Ala 
            180                 185                 190         


Glu Thr Pro Thr Arg Leu Leu Leu Ala Tyr Asp Ile Gln Gly Pro Gly 
        195                 200                 205             


Leu Val Ala Asn Lys Thr Lys Trp Ala Lys Leu Pro Asp Cys Glu Gln 
    210                 215                 220                 


Glu Gly Gly Gly Asp Gly Met Asp Phe Asp Asp Ala Gly Asn Leu Leu 
225                 230                 235                 240 


Val Ala His Trp Gly Ala Gly His Ile Glu Val Phe Gly Pro Asp Gly 
                245                 250                 255     


Gly Glu Pro Ile Lys Arg Ile Lys Cys Pro Phe Asp Lys Pro Ser Asn 
            260                 265                 270         


Val His Phe Glu Pro Asn Ser Asn Ile Val Tyr Val Thr Glu His Thr 
        275                 280                 285             


Asn Asn Ala Leu Trp Lys Phe Gln Trp Glu Asn Lys Gly Met Pro Gln 
    290                 295                 300                 


Tyr Cys Asp Lys Asn 
305                 


