                         SEQUENCE LISTING

<110>  INTEGRAGEN
 
<120>  A method for predicting responsiveness to a treatment with an 
       EGFR inhibitor

<130>  366346D32652

<150>  EP 13306619.1
<151>  2013-11-26

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  homo sapiens

<400>  1
ugcuaugcca acauauugcc au                                                22


<210>  2
<211>  1165
<212>  DNA
<213>  homo sapiens

<400>  2
gtgcttggta ggttgggcgg cggctctgtc tagtcccaga gccaggaatc aggggcagcc       60

gggcgagtcc cagggcaggg gtcctccgcc gccttgcacc tgccctgctg ggcggcaccg      120

ggtcagtgcc ctgccccctc ctgcgggtcc caactctctc tttcccatcg tgcgtcctct      180

ggagaagtgc gcgcgtgagc tgacatggac ccaaatcctc gggccgccct ggagcgccag      240

cagctccgcc ttcgggagcg gcaaaaattc ttcgaggaca ttttacagcc agagacagag      300

tttgtctttc ctctgtccca tctgcatctc gagtcgcaga gaccccccat aggtagtatc      360

tcatccatgg aagtgaatgt ggacacactg gagcaagtag aacttattga ccttggggac      420

ccggatgcag cagatgtgtt cttgccttgc gaagatcctc caccaacccc ccagtcgtct      480

gggatggaca accatttgga ggagctgagc ctgccggtgc ctacatcaga caggaccaca      540

tctaggacct cctcctcctc ctcctccgac tcctccacca acctgcatag cccaaatcca      600

agtgatgatg gagcagatac gcccttggca cagtcggatg aagaggagga aaggggtgat      660

ggaggggcag agcctggagc ctgcagctag cagtgggccc ctgcctacag actgaccacg      720

ctggctattc tccacatgag accacaggcc cagccagagc ctgtcgggag aagaccagac      780

tctttacttg cagtaggcac cagaggtggg aaggatggtg ggattgtgta cctttctaag      840

aattaaccct ctcctgcttt actgctaatt ttttcctgct gcaaccctcc caccagtttt      900

tggcttactc ctgagatatg atttgcaaat gaggagagag aagatgaggt tggacaagat      960

gccactgctt ttcttagcac tcttccctcc cctaaaccat cccgtagtct tctaatacag     1020

tctctcagac aagtgtctct agatggatgt gaactcctta actcatcaag taaggtggta     1080

ctcaagccat gctgcctcct tacatccttt ttggaacaga gcacggtata aataataaac     1140

taataataat atgccaacca aaaaa                                           1165


<210>  3
<211>  1114
<212>  DNA
<213>  homo sapiens

<400>  3
ctcgttcccg gctcccaggg cccgtcggtc ccccgggagc cctggaggcg cagccccacc       60

ccggccggcg cggctcgctc ccacgccccc gccgcggcct cgctggagcg gacggactga      120

gtcagagggg gcgccagcgc tgcaggagct gacatggacc caaatcctcg ggccgccctg      180

gagcgccagc agctccgcct tcgggagcgg caaaaattct tcgaggacat tttacagcca      240

gagacagagt ttgtctttcc tctgtcccat ctgcatctcg agtcgcagag accccccata      300

ggtagtatct catccatgga agtgaatgtg gacacactgg agcaagtaga acttattgac      360

cttggggacc cggatgcagc agatgtgttc ttgccttgcg aagatcctcc accaaccccc      420

cagtcgtctg ggatggacaa ccatttggag gagctgagcc tgccggtgcc tacatcagac      480

aggaccacat ctaggacctc ctcctcctcc tcctccgact cctccaccaa cctgcatagc      540

ccaaatccaa gtgatgatgg agcagatacg cccttggcac agtcggatga agaggaggaa      600

aggggtgatg gaggggcaga gcctggagcc tgcagctagc agtgggcccc tgcctacaga      660

ctgaccacgc tggctattct ccacatgaga ccacaggccc agccagagcc tgtcgggaga      720

agaccagact ctttacttgc agtaggcacc agaggtggga aggatggtgg gattgtgtac      780

ctttctaaga attaaccctc tcctgcttta ctgctaattt tttcctgctg caaccctccc      840

accagttttt ggcttactcc tgagatatga tttgcaaatg aggagagaga agatgaggtt      900

ggacaagatg ccactgcttt tcttagcact cttccctccc ctaaaccatc ccgtagtctt      960

ctaatacagt ctctcagaca agtgtctcta gatggatgtg aactccttaa ctcatcaagt     1020

aaggtggtac tcaagccatg ctgcctcctt acatcctttt tggaacagag cacggtataa     1080

ataataaact aataataata tgccaaccaa aaaa                                 1114


<210>  4
<211>  998
<212>  DNA
<213>  homo sapiens

<400>  4
cccggcgccc accccgccca gtgtgcttgg agctgacatg gacccaaatc ctcgggccgc       60

cctggagcgc cagcagctcc gccttcggga gcggcaaaaa ttcttcgagg acattttaca      120

gccagagaca gagtttgtct ttcctctgtc ccatctgcat ctcgagtcgc agagaccccc      180

cataggtagt atctcatcca tggaagtgaa tgtggacaca ctggagcaag tagaacttat      240

tgaccttggg gacccggatg cagcagatgt gttcttgcct tgcgaagatc ctccaccaac      300

cccccagtcg tctgggatgg acaaccattt ggaggagctg agcctgccgg tgcctacatc      360

agacaggacc acatctagga cctcctcctc ctcctcctcc gactcctcca ccaacctgca      420

tagcccaaat ccaagtgatg atggagcaga tacgcccttg gcacagtcgg atgaagagga      480

ggaaaggggt gatggagggg cagagcctgg agcctgcagc tagcagtggg cccctgccta      540

cagactgacc acgctggcta ttctccacat gagaccacag gcccagccag agcctgtcgg      600

gagaagacca gactctttac ttgcagtagg caccagaggt gggaaggatg gtgggattgt      660

gtacctttct aagaattaac cctctcctgc tttactgcta attttttcct gctgcaaccc      720

tcccaccagt ttttggctta ctcctgagat atgatttgca aatgaggaga gagaagatga      780

ggttggacaa gatgccactg cttttcttag cactcttccc tcccctaaac catcccgtag      840

tcttctaata cagtctctca gacaagtgtc tctagatgga tgtgaactcc ttaactcatc      900

aagtaaggtg gtactcaagc catgctgcct ccttacatcc tttttggaac agagcacggt      960

ataaataata aactaataat aatatgccaa ccaaaaaa                              998


<210>  5
<211>  1044
<212>  DNA
<213>  homo sapiens

<400>  5
atcgtgcgtc ctctggagaa gtgcgcgcgt gtaagtgtgg cgagtgtggc caagggtgcc       60

ggaggcaggg ttcgggagct gacatggacc caaatcctcg ggccgccctg gagcgccagc      120

agctccgcct tcgggagcgg caaaaattct tcgaggacat tttacagcca gagacagagt      180

ttgtctttcc tctgtcccat ctgcatctcg agtcgcagag accccccata ggtagtatct      240

catccatgga agtgaatgtg gacacactgg agcaagtaga acttattgac cttggggacc      300

cggatgcagc agatgtgttc ttgccttgcg aagatcctcc accaaccccc cagtcgtctg      360

ggatggacaa ccatttggag gagctgagcc tgccggtgcc tacatcagac aggaccacat      420

ctaggacctc ctcctcctcc tcctccgact cctccaccaa cctgcatagc ccaaatccaa      480

gtgatgatgg agcagatacg cccttggcac agtcggatga agaggaggaa aggggtgatg      540

gaggggcaga gcctggagcc tgcagctagc agtgggcccc tgcctacaga ctgaccacgc      600

tggctattct ccacatgaga ccacaggccc agccagagcc tgtcgggaga agaccagact      660

ctttacttgc agtaggcacc agaggtggga aggatggtgg gattgtgtac ctttctaaga      720

attaaccctc tcctgcttta ctgctaattt tttcctgctg caaccctccc accagttttt      780

ggcttactcc tgagatatga tttgcaaatg aggagagaga agatgaggtt ggacaagatg      840

ccactgcttt tcttagcact cttccctccc ctaaaccatc ccgtagtctt ctaatacagt      900

ctctcagaca agtgtctcta gatggatgtg aactccttaa ctcatcaagt aaggtggtac      960

tcaagccatg ctgcctcctt acatcctttt tggaacagag cacggtataa ataataaact     1020

aataataata tgccaaccaa aaaa                                            1044


<210>  6
<211>  1263
<212>  DNA
<213>  homo sapiens

<400>  6
gtgcttggta ggttgggcgg cggctctgtc tagtcccaga gccaggaatc aggggcagcc       60

gggcgagtcc cagggcaggg gtcctccgcc gccttgcacc tgccctgctg ggcggcaccg      120

ggtcagtgcc ctgccccctc ctgcgggtcc caactctctc tttcccatcg tgcgtcctct      180

ggagaagtgc gcgcgtgagc tgacatggac ccaaatcctc gggccgccct ggagcgccag      240

cagctccgcc ttcgggagcg gcaaaaattc ttcgaggaca ttttacagcc agagacagag      300

tttgtctttc ctctgtccca tctgcatctc gagtcgcaga gaccccccat aggtagtatc      360

tcatccatgg aagtgaatgt ggacacactg gagcaagtag aacttattga ccttggggac      420

ccggatgcag cagatgtgtt cttgccttgc gaagatcctc caccaacccc ccagtcgtct      480

ggtatgcccc tctgctttgg ggacttcagt gccagtcagc cagagccgga tgtcaggctc      540

tgaaacgagg ctacaaggct gggctgggga agtacacaag gatggacaac catttggagg      600

agctgagcct gccggtgcct acatcagaca ggaccacatc taggacctcc tcctcctcct      660

cctccgactc ctccaccaac ctgcatagcc caaatccaag tgatgatgga gcagatacgc      720

ccttggcaca gtcggatgaa gaggaggaaa ggggtgatgg aggggcagag cctggagcct      780

gcagctagca gtgggcccct gcctacagac tgaccacgct ggctattctc cacatgagac      840

cacaggccca gccagagcct gtcgggagaa gaccagactc tttacttgca gtaggcacca      900

gaggtgggaa ggatggtggg attgtgtacc tttctaagaa ttaaccctct cctgctttac      960

tgctaatttt ttcctgctgc aaccctccca ccagtttttg gcttactcct gagatatgat     1020

ttgcaaatga ggagagagaa gatgaggttg gacaagatgc cactgctttt cttagcactc     1080

ttccctcccc taaaccatcc cgtagtcttc taatacagtc tctcagacaa gtgtctctag     1140

atggatgtga actccttaac tcatcaagta aggtggtact caagccatgc tgcctcctta     1200

catccttttt ggaacagagc acggtataaa taataaacta ataataatat gccaaccaaa     1260

aaa                                                                   1263


<210>  7
<211>  1212
<212>  DNA
<213>  homo sapiens

<400>  7
ctcgttcccg gctcccaggg cccgtcggtc ccccgggagc cctggaggcg cagccccacc       60

ccggccggcg cggctcgctc ccacgccccc gccgcggcct cgctggagcg gacggactga      120

gtcagagggg gcgccagcgc tgcaggagct gacatggacc caaatcctcg ggccgccctg      180

gagcgccagc agctccgcct tcgggagcgg caaaaattct tcgaggacat tttacagcca      240

gagacagagt ttgtctttcc tctgtcccat ctgcatctcg agtcgcagag accccccata      300

ggtagtatct catccatgga agtgaatgtg gacacactgg agcaagtaga acttattgac      360

cttggggacc cggatgcagc agatgtgttc ttgccttgcg aagatcctcc accaaccccc      420

cagtcgtctg gtatgcccct ctgctttggg gacttcagtg ccagtcagcc agagccggat      480

gtcaggctct gaaacgaggc tacaaggctg ggctggggaa gtacacaagg atggacaacc      540

atttggagga gctgagcctg ccggtgccta catcagacag gaccacatct aggacctcct      600

cctcctcctc ctccgactcc tccaccaacc tgcatagccc aaatccaagt gatgatggag      660

cagatacgcc cttggcacag tcggatgaag aggaggaaag gggtgatgga ggggcagagc      720

ctggagcctg cagctagcag tgggcccctg cctacagact gaccacgctg gctattctcc      780

acatgagacc acaggcccag ccagagcctg tcgggagaag accagactct ttacttgcag      840

taggcaccag aggtgggaag gatggtggga ttgtgtacct ttctaagaat taaccctctc      900

ctgctttact gctaattttt tcctgctgca accctcccac cagtttttgg cttactcctg      960

agatatgatt tgcaaatgag gagagagaag atgaggttgg acaagatgcc actgcttttc     1020

ttagcactct tccctcccct aaaccatccc gtagtcttct aatacagtct ctcagacaag     1080

tgtctctaga tggatgtgaa ctccttaact catcaagtaa ggtggtactc aagccatgct     1140

gcctccttac atcctttttg gaacagagca cggtataaat aataaactaa taataatatg     1200

ccaaccaaaa aa                                                         1212


<210>  8
<211>  1440
<212>  DNA
<213>  homo sapiens

<400>  8
tgggaagggg tgggctgcag cactggagga agggaaccct ccaccctgag atctctgtct       60

ctatcctatc ctgtccctgg ccttctgagg caagcggggc caattaaggg gaaaacgtac      120

ctcctccatt tgtgctgaac caatccctcc aacccctctc aggagggcat gatatggaga      180

gttgggcatt ggctgtgttc cctgaataca gagtatctct cttgtggtgc ctggaactgg      240

catccccttt gtggagctta gggcaagccc cgcctctgca tgagacttgg tttgtgggac      300

acacttggtt tcagggaagg ggaaagaggt caccaagggc agaggtgtcc aggccggagc      360

caggggcccc actgttggga tgctggctgc agtggggcgc cccaagccca ggtcccctct      420

gtcttctctt tcgactttgc agctgtactt gttttgctcc tctacccgca ggagctgaca      480

tggacccaaa tcctcgggcc gccctggagc gccagcagct ccgccttcgg gagcggcaaa      540

aattcttcga ggacatttta cagccagaga cagagtttgt ctttcctctg tcccatctgc      600

atctcgagtc gcagagaccc cccataggta gtatctcatc catggaagtg aatgtggaca      660

cactggagca agtagaactt attgaccttg gggacccgga tgcagcagat gtgttcttgc      720

cttgcgaaga tcctccacca accccccagt cgtctgggat ggacaaccat ttggaggagc      780

tgagcctgcc ggtgcctaca tcagacagga ccacatctag gacctcctcc tcctcctcct      840

ccgactcctc caccaacctg catagcccaa atccaagtga tgatggagca gatacgccct      900

tggcacagtc ggatgaagag gaggaaaggg gtgatggagg ggcagagcct ggagcctgca      960

gctagcagtg ggcccctgcc tacagactga ccacgctggc tattctccac atgagaccac     1020

aggcccagcc agagcctgtc gggagaagac cagactcttt acttgcagta ggcaccagag     1080

gtgggaagga tggtgggatt gtgtaccttt ctaagaatta accctctcct gctttactgc     1140

taattttttc ctgctgcaac cctcccacca gtttttggct tactcctgag atatgatttg     1200

caaatgagga gagagaagat gaggttggac aagatgccac tgcttttctt agcactcttc     1260

cctcccctaa accatcccgt agtcttctaa tacagtctct cagacaagtg tctctagatg     1320

gatgtgaact ccttaactca tcaagtaagg tggtactcaa gccatgctgc ctccttacat     1380

cctttttgga acagagcacg gtataaataa taaactaata ataatatgcc aaccaaaaaa     1440


<210>  9
<211>  1538
<212>  DNA
<213>  homo sapiens

<400>  9
tgggaagggg tgggctgcag cactggagga agggaaccct ccaccctgag atctctgtct       60

ctatcctatc ctgtccctgg ccttctgagg caagcggggc caattaaggg gaaaacgtac      120

ctcctccatt tgtgctgaac caatccctcc aacccctctc aggagggcat gatatggaga      180

gttgggcatt ggctgtgttc cctgaataca gagtatctct cttgtggtgc ctggaactgg      240

catccccttt gtggagctta gggcaagccc cgcctctgca tgagacttgg tttgtgggac      300

acacttggtt tcagggaagg ggaaagaggt caccaagggc agaggtgtcc aggccggagc      360

caggggcccc actgttggga tgctggctgc agtggggcgc cccaagccca ggtcccctct      420

gtcttctctt tcgactttgc agctgtactt gttttgctcc tctacccgca ggagctgaca      480

tggacccaaa tcctcgggcc gccctggagc gccagcagct ccgccttcgg gagcggcaaa      540

aattcttcga ggacatttta cagccagaga cagagtttgt ctttcctctg tcccatctgc      600

atctcgagtc gcagagaccc cccataggta gtatctcatc catggaagtg aatgtggaca      660

cactggagca agtagaactt attgaccttg gggacccgga tgcagcagat gtgttcttgc      720

cttgcgaaga tcctccacca accccccagt cgtctggtat gcccctctgc tttggggact      780

tcagtgccag tcagccagag ccggatgtca ggctctgaaa cgaggctaca aggctgggct      840

ggggaagtac acaaggatgg acaaccattt ggaggagctg agcctgccgg tgcctacatc      900

agacaggacc acatctagga cctcctcctc ctcctcctcc gactcctcca ccaacctgca      960

tagcccaaat ccaagtgatg atggagcaga tacgcccttg gcacagtcgg atgaagagga     1020

ggaaaggggt gatggagggg cagagcctgg agcctgcagc tagcagtggg cccctgccta     1080

cagactgacc acgctggcta ttctccacat gagaccacag gcccagccag agcctgtcgg     1140

gagaagacca gactctttac ttgcagtagg caccagaggt gggaaggatg gtgggattgt     1200

gtacctttct aagaattaac cctctcctgc tttactgcta attttttcct gctgcaaccc     1260

tcccaccagt ttttggctta ctcctgagat atgatttgca aatgaggaga gagaagatga     1320

ggttggacaa gatgccactg cttttcttag cactcttccc tcccctaaac catcccgtag     1380

tcttctaata cagtctctca gacaagtgtc tctagatgga tgtgaactcc ttaactcatc     1440

aagtaaggtg gtactcaagc catgctgcct ccttacatcc tttttggaac agagcacggt     1500

ataaataata aactaataat aatatgccaa ccaaaaaa                             1538


<210>  10
<211>  1486
<212>  DNA
<213>  homo sapiens

<400>  10
cgagtgtggc caagggtgcc ggaggcaggg ttcgggtgcg tagtcgttgc gtgggcgctg       60

cccaaaaggc gcagagcatc aagtgtgcgt gggcagaacc ggcgcgggcg cccgccgcgg      120

gtctgcgcgg ggcgggggcg cagcaagtgc atccgagcga gcggagacta gcgcaccggc      180

gtcggtggcg agggtggtgc agaggagtcc ggctgggcgg agggaggaag gatgggtgcg      240

ggtaactttt tgaccgcctt ggaagtacca gtagccgcgc tcgcaggggc tgcctccgac      300

cgccgggcga gctgcgagcg agtgagcccg ccaccgcccc tcccccactt ccgcctcccg      360

cctcttcctc gttcccggct cccagggccc gtgtccaggc cggagccagg ggccccactg      420

ttgggatgct ggctgcagtg gggcgcccca agcccaggtc ccctctgtct tctctttcga      480

ctttgcagct gtacttgttt tgctcctcta cccgcaggag ctgacatgga cccaaatcct      540

cgggccgccc tggagcgcca gcagctccgc cttcgggagc ggcaaaaatt cttcgaggac      600

attttacagc cagagacaga gtttgtcttt cctctgtccc atctgcatct cgagtcgcag      660

agacccccca taggtagtat ctcatccatg gaagtgaatg tggacacact ggagcaagta      720

gaacttattg accttgggga cccggatgca gcagatgtgt tcttgccttg cgaagatcct      780

ccaccaaccc cccagtcgtc tgggatggac aaccatttgg aggagctgag cctgccggtg      840

cctacatcag acaggaccac atctaggacc tcctcctcct cctcctccga ctcctccacc      900

aacctgcata gcccaaatcc aagtgatgat ggagcagata cgcccttggc acagtcggat      960

gaagaggagg aaaggggtga tggaggggca gagcctggag cctgcagcta gcagtgggcc     1020

cctgcctaca gactgaccac gctggctatt ctccacatga gaccacaggc ccagccagag     1080

cctgtcggga gaagaccaga ctctttactt gcagtaggca ccagaggtgg gaaggatggt     1140

gggattgtgt acctttctaa gaattaaccc tctcctgctt tactgctaat tttttcctgc     1200

tgcaaccctc ccaccagttt ttggcttact cctgagatat gatttgcaaa tgaggagaga     1260

gaagatgagg ttggacaaga tgccactgct tttcttagca ctcttccctc ccctaaacca     1320

tcccgtagtc ttctaataca gtctctcaga caagtgtctc tagatggatg tgaactcctt     1380

aactcatcaa gtaaggtggt actcaagcca tgctgcctcc ttacatcctt tttggaacag     1440

agcacggtat aaataataaa ctaataataa tatgccaacc aaaaaa                    1486


<210>  11
<211>  161
<212>  PRT
<213>  homo sapiens

<400>  11

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Asp Asn 
                85                  90                  95      


His Leu Glu Glu Leu Ser Leu Pro Val Pro Thr Ser Asp Arg Thr Thr 
            100                 105                 110         


Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr Asn Leu His 
        115                 120                 125             


Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp Thr Pro Leu Ala Gln Ser 
    130                 135                 140                 


Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly Ala Glu Pro Gly Ala Cys 
145                 150                 155                 160 


Ser 
    


<210>  12
<211>  161
<212>  PRT
<213>  homo sapiens

<400>  12

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Asp Asn 
                85                  90                  95      


His Leu Glu Glu Leu Ser Leu Pro Val Pro Thr Ser Asp Arg Thr Thr 
            100                 105                 110         


Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr Asn Leu His 
        115                 120                 125             


Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp Thr Pro Leu Ala Gln Ser 
    130                 135                 140                 


Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly Ala Glu Pro Gly Ala Cys 
145                 150                 155                 160 


Ser 
    


<210>  13
<211>  161
<212>  PRT
<213>  homo sapiens

<400>  13

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Asp Asn 
                85                  90                  95      


His Leu Glu Glu Leu Ser Leu Pro Val Pro Thr Ser Asp Arg Thr Thr 
            100                 105                 110         


Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr Asn Leu His 
        115                 120                 125             


Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp Thr Pro Leu Ala Gln Ser 
    130                 135                 140                 


Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly Ala Glu Pro Gly Ala Cys 
145                 150                 155                 160 


Ser 
    


<210>  14
<211>  161
<212>  PRT
<213>  homo sapiens

<400>  14

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Asp Asn 
                85                  90                  95      


His Leu Glu Glu Leu Ser Leu Pro Val Pro Thr Ser Asp Arg Thr Thr 
            100                 105                 110         


Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr Asn Leu His 
        115                 120                 125             


Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp Thr Pro Leu Ala Gln Ser 
    130                 135                 140                 


Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly Ala Glu Pro Gly Ala Cys 
145                 150                 155                 160 


Ser 
    


<210>  15
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  15

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Pro Leu 
                85                  90                  95      


Cys Phe Gly Asp Phe Ser Ala Ser Gln Pro Glu Pro Asp Val Arg Leu 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  16

Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu 
1               5                   10                  15      


Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu 
            20                  25                  30          


Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg Pro Pro 
        35                  40                  45              


Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu Glu Gln 
    50                  55                  60                  


Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val Phe Leu 
65                  70                  75                  80  


Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met Pro Leu 
                85                  90                  95      


Cys Phe Gly Asp Phe Ser Ala Ser Gln Pro Glu Pro Asp Val Arg Leu 
            100                 105                 110         


<210>  17
<211>  263
<212>  PRT
<213>  homo sapiens

<400>  17

Met Glu Ser Trp Ala Leu Ala Val Phe Pro Glu Tyr Arg Val Ser Leu 
1               5                   10                  15      


Leu Trp Cys Leu Glu Leu Ala Ser Pro Leu Trp Ser Leu Gly Gln Ala 
            20                  25                  30          


Pro Pro Leu His Glu Thr Trp Phe Val Gly His Thr Trp Phe Gln Gly 
        35                  40                  45              


Arg Gly Lys Arg Ser Pro Arg Ala Glu Val Ser Arg Pro Glu Pro Gly 
    50                  55                  60                  


Ala Pro Leu Leu Gly Cys Trp Leu Gln Trp Gly Ala Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Leu Cys Leu Leu Phe Arg Leu Cys Ser Cys Thr Cys Phe Ala Pro 
                85                  90                  95      


Leu Pro Ala Gly Ala Asp Met Asp Pro Asn Pro Arg Ala Ala Leu Glu 
            100                 105                 110         


Arg Gln Gln Leu Arg Leu Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile 
        115                 120                 125             


Leu Gln Pro Glu Thr Glu Phe Val Phe Pro Leu Ser His Leu His Leu 
    130                 135                 140                 


Glu Ser Gln Arg Pro Pro Ile Gly Ser Ile Ser Ser Met Glu Val Asn 
145                 150                 155                 160 


Val Asp Thr Leu Glu Gln Val Glu Leu Ile Asp Leu Gly Asp Pro Asp 
                165                 170                 175     


Ala Ala Asp Val Phe Leu Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln 
            180                 185                 190         


Ser Ser Gly Met Asp Asn His Leu Glu Glu Leu Ser Leu Pro Val Pro 
        195                 200                 205             


Thr Ser Asp Arg Thr Thr Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp 
    210                 215                 220                 


Ser Ser Thr Asn Leu His Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp 
225                 230                 235                 240 


Thr Pro Leu Ala Gln Ser Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly 
                245                 250                 255     


Ala Glu Pro Gly Ala Cys Ser 
            260             


<210>  18
<211>  214
<212>  PRT
<213>  homo sapiens

<400>  18

Met Glu Ser Trp Ala Leu Ala Val Phe Pro Glu Tyr Arg Val Ser Leu 
1               5                   10                  15      


Leu Trp Cys Leu Glu Leu Ala Ser Pro Leu Trp Ser Leu Gly Gln Ala 
            20                  25                  30          


Pro Pro Leu His Glu Thr Trp Phe Val Gly His Thr Trp Phe Gln Gly 
        35                  40                  45              


Arg Gly Lys Arg Ser Pro Arg Ala Glu Val Ser Arg Pro Glu Pro Gly 
    50                  55                  60                  


Ala Pro Leu Leu Gly Cys Trp Leu Gln Trp Gly Ala Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Leu Cys Leu Leu Phe Arg Leu Cys Ser Cys Thr Cys Phe Ala Pro 
                85                  90                  95      


Leu Pro Ala Gly Ala Asp Met Asp Pro Asn Pro Arg Ala Ala Leu Glu 
            100                 105                 110         


Arg Gln Gln Leu Arg Leu Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile 
        115                 120                 125             


Leu Gln Pro Glu Thr Glu Phe Val Phe Pro Leu Ser His Leu His Leu 
    130                 135                 140                 


Glu Ser Gln Arg Pro Pro Ile Gly Ser Ile Ser Ser Met Glu Val Asn 
145                 150                 155                 160 


Val Asp Thr Leu Glu Gln Val Glu Leu Ile Asp Leu Gly Asp Pro Asp 
                165                 170                 175     


Ala Ala Asp Val Phe Leu Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln 
            180                 185                 190         


Ser Ser Gly Met Pro Leu Cys Phe Gly Asp Phe Ser Ala Ser Gln Pro 
        195                 200                 205             


Glu Pro Asp Val Arg Leu 
    210                 


<210>  19
<211>  259
<212>  PRT
<213>  homo sapiens

<400>  19

Met Gly Ala Gly Asn Phe Leu Thr Ala Leu Glu Val Pro Val Ala Ala 
1               5                   10                  15      


Leu Ala Gly Ala Ala Ser Asp Arg Arg Ala Ser Cys Glu Arg Val Ser 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro His Phe Arg Leu Pro Pro Leu Pro Arg Ser 
        35                  40                  45              


Arg Leu Pro Gly Pro Val Ser Arg Pro Glu Pro Gly Ala Pro Leu Leu 
    50                  55                  60                  


Gly Cys Trp Leu Gln Trp Gly Ala Pro Ser Pro Gly Pro Leu Cys Leu 
65                  70                  75                  80  


Leu Phe Arg Leu Cys Ser Cys Thr Cys Phe Ala Pro Leu Pro Ala Gly 
                85                  90                  95      


Ala Asp Met Asp Pro Asn Pro Arg Ala Ala Leu Glu Arg Gln Gln Leu 
            100                 105                 110         


Arg Leu Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile Leu Gln Pro Glu 
        115                 120                 125             


Thr Glu Phe Val Phe Pro Leu Ser His Leu His Leu Glu Ser Gln Arg 
    130                 135                 140                 


Pro Pro Ile Gly Ser Ile Ser Ser Met Glu Val Asn Val Asp Thr Leu 
145                 150                 155                 160 


Glu Gln Val Glu Leu Ile Asp Leu Gly Asp Pro Asp Ala Ala Asp Val 
                165                 170                 175     


Phe Leu Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln Ser Ser Gly Met 
            180                 185                 190         


Asp Asn His Leu Glu Glu Leu Ser Leu Pro Val Pro Thr Ser Asp Arg 
        195                 200                 205             


Thr Thr Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr Asn 
    210                 215                 220                 


Leu His Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp Thr Pro Leu Ala 
225                 230                 235                 240 


Gln Ser Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly Ala Glu Pro Gly 
                245                 250                 255     


Ala Cys Ser 
            


<210>  20
<211>  3783
<212>  DNA
<213>  homo sapiens

<400>  20
caggccgccg gcccgggaga gcgcgcggcg gcggcggcgg cgggacggcc ccgagcgcgc       60

cctcccgcct gcggccactc gcagccggcg ctggccgggc cggcgcgccc cgcaggcggc      120

tagagcgcgg cctcggcctc ggcgcgggct tgccccgggc cgtagcccgc gagaggcggc      180

gcgggcggcc gagggcactg acggcgtcgc gggacgctcc cgggcggcgg cgcagcggca      240

gcggcagcgg cagcggcagc gcagggggcg gaggcagggg gcgcccccag ccaggatgct      300

gcggttcctg cgccggacct ttggccgccg ctccatgcag cgctacgcgc ggggcgcggc      360

ggggcgcggg gccgccgggc tgggggacga gcgcgatggg gggccacggg ggggcccggc      420

cgccgccgcc tcctcctcgg cgctgcccgc cgcgcccggg ggcagcgtgt tcccggcggg      480

cggcgggccc ctgctcaccg gcggcgcggc cgtgcacatc tccgccgccg gcgccgccaa      540

ggccaccctc tactgccgcg tcttcctgct cgacgggacc gaagtgagcg tggacctgcc      600

gaaacatgcc aaaggccagg atttgtttga tcagattgtg taccacttgg accttgtgga      660

aacagattac tttggcctcc agttcctcga ctctgcccag gttgcgcact ggctggatca      720

tgccaaaccc ataaaaaagc agatgaaaat tggacctgct tatgctttac actttcgagt      780

taaatactat tcttcagaac caaacaacct tcgtgaggag tttacaaggt acctgtttgt      840

tttacaactc aggcatgaca ttctttctgg aaaattgaaa tgcccttatg aaacagctgt      900

ggaattagct gctctctgtc tacaagcgga gcttggggag tgcgagcttc cagaacacac      960

accagagctt gtgtctgagt ttcggttcat tccaaatcag acagaagcaa tggaatttga     1020

tatcttccag agatggaaag agtgcagggg aaagagccct gcccaggcgg aactctccta     1080

tctgaataaa gcgaagtggc tggaaatgta tggggtagac atgcacgttg tcaggggaag     1140

agatggctgt gaatattctc ttggactgac cccgacaggc atattaatct ttgaaggagc     1200

taacaaaata ggcttattct tttggcctaa aattaccaaa atggatttta aaaagagcaa     1260

attgacactc gtggtggtcg aggatgatga tcagggacgt gagcaagagc acacgtttgt     1320

gttccggtta gacagtgcca ggacctgcaa acacctttgg aagtgtgcag ttgagcacca     1380

cgcattcttc cgactgcgga cgccaggaaa cagcaaatcc aatagatccg actttatcag     1440

gctgggctct cgcttcagat tcagtgggcg gacagaatat caagctacac atggctccag     1500

gttacgaaga accagcacct ttgagaggaa gcctagtaaa cgttatccat cccggagaca     1560

ttcaacgttc aaagcaagca acccagtgat agcagcccag ctctgctcta aaacaaatcc     1620

agaagtccat aattaccagc ctcaatatca tcctaatatc catcccagcc agccccggtg     1680

gcatcctcac tctccaaatg tcaggccatc ctttcaggat gacaggtcgc attggaaagc     1740

atcggccagt ggagatgaca gccattttga ttatgtccac gaccagaacc agaagaactt     1800

aggagggatg caaagtatga tgtatcgaga taaactcatg actgcacttt gagagactga     1860

agcatctctc ttccattcac cttcatagtt tcattgcatt ccatgaaaag tgtcttggcc     1920

tcagatggat ggatgtgttt ggacgagtgt ctttaaggag tagtcctgaa aggtgttttt     1980

ggtgtccatg taaatatttg aagataaaac cactatagct tgtcataatt tactgttgac     2040

tgcattctca ttaaaatgaa ggtaaaggct caggaatcat attgatgttc tgattttaaa     2100

attggagtca aagtctatgt ttatcatttt actatgttcc tgatgttctt tgttatttaa     2160

ttaatgggag caaataaaac cagaagagct tgggaagatt gctcagcata tattcctgtc     2220

gtagaagttg agattgctag ggtccagttt ccctagtgtg gcctggacga gtcatttccc     2280

cttcattgac ctcattttcc ccatctgaaa agagagggtt ggactaagtg atctccaagg     2340

tcctttccaa ctctaaaatt ctgcaatttg ttaacatttc attttgttta ggttgaggac     2400

atacattcaa actaatttta tcacaaggaa aactgcaata cccacttcct tgacagagtt     2460

actcctttca gaagctaaat aaagtatata acttattaga tgttatatag atacaggggg     2520

actttgaatt tcacatctta aagcagttga gctactttga atttaagcag tcgtactaat     2580

cttaaattgc atagcatttg ttttgatcga atttgctgct caagtatggg aataattttt     2640

aatgtcttaa tgattggtgc tgctaacttg cgtgatttca gaagacataa ttgtgaatac     2700

acactgtcag aattggggga ttggttttta ccctagactt cactcttaaa aagcaacgtg     2760

caatcaagat catttatggc tcaaatgaaa gcatataagg ttttcttgaa gttgtgccaa     2820

agcattctgt agagtaggat gagatggttg ttgccctagt ctgttggtag aaccagaaat     2880

caatatgttg tcttttaggt taaagcttgt accaaaatat ttatttcccc catttcaagc     2940

cctgagtcaa acattttttt ctcttaataa tagacctgaa atgttttatt agtatttctg     3000

tgaaatcagt tgattcttgt gccatttttg tatatgtaat tgtaattttg cccatgttag     3060

gccctctaaa aaatgtttga catcctttga gatattttat tactaaaatc tgatcttttt     3120

tggctactgc aaaaatctat tcagcaagaa ggtatcagct gcataccttg cacagtggag     3180

ctgactacct ataaactctc cctaaggcat ttgtttacag gtgtattcca ttttagcaga     3240

cgttctgatg ctcagtgtat gtgctgcata caaataaatg tgttctgaat cttttcatct     3300

tattgatagc atttttacaa atgtgtttcc aaggaataaa gattattctt gctttttttt     3360

tgactccatc ttcatttttt ttaaattgat tcttgttgct atgcagaagt ctcatttgtg     3420

aatgaccttg gtaacagaac agttggcttt tggaagtctg aaggtgagca ttcagttagg     3480

tgggtggagc aagatcatcc tagaatgagg ctgctcttgg caagagtgga tcttataggc     3540

acagcagctg atgcctttct tcatctgggg caactctggt gaaggttgtc ctgcctgtca     3600

caggtgctga gtagagagaa gtggtggcag tgggatttcc tcagtaatag tcctgtaaag     3660

gtacgtgttt gtcctggcta cttgtgctct tcctggcagg aaggcatcca aacccttatc     3720

tgtgggctcc tggaaattgt gtatgccata taataccctc taataaatac ctctctgctt     3780

aaa                                                                   3783


<210>  21
<211>  5578
<212>  DNA
<213>  homo sapiens

<400>  21
caggccgccg gcccgggaga gcgcgcggcg gcggcggcgg cgggacggcc ccgagcgcgc       60

cctcccgcct gcggccactc gcagccggcg ctggccgggc cggcgcgccc cgcaggcggc      120

tagagcgcgg cctcggcctc ggcgcgggct tgccccgggc cgtagcccgc gagaggcggc      180

gcgggcggcc gagggcactg acggcgtcgc gggacgctcc cgggcggcgg cgcagcggca      240

gcggcagcgg cagcggcagc gcagggggcg gaggcagggg gcgcccccag ccaggatgct      300

gcggttcctg cgccggacct ttggccgccg ctccatgcag cgctacgcgc ggggcgcggc      360

ggggcgcggg gccgccgggc tgggggacga gcgcgatggg gggccacggg ggggcccggc      420

cgccgccgcc tcctcctcgg cgctgcccgc cgcgcccggg ggcagcgtgt tcccggcggg      480

cggcgggccc ctgctcaccg gcggcgcggc cgtgcacatc tccgccgccg gcgccgccaa      540

ggccaccctc tactgccgcg tcttcctgct cgacgggacc gaagtgagcg tggacctgcc      600

gaaacatgcc aaaggccagg atttgtttga tcagattgtg taccacttgg accttgtgga      660

aacagattac tttggcctcc agttcctcga ctctgcccag gttgcgcact ggctggatca      720

tgccaaaccc ataaaaaagc agatgaaaat tggacctgct tatgctttac actttcgagt      780

taaatactat tcttcagaac caaacaacct tcgtgaggag tttacaaggt acctgtttgt      840

tttacaactc aggcatgaca ttctttctgg aaaattgaaa tgcccttatg aaacagctgt      900

ggaattagct gctctctgtc tacaagcgga gcttggggag tgcgagcttc cagaacacac      960

accagagctt gtgtctgagt ttcggttcat tccaaatcag acagaagcaa tggaatttga     1020

tatcttccag agatggaaag agtgcagggg aaagagccct gcccaggcgg aactctccta     1080

tctgaataaa gcgaagtggc tggaaatgta tggggtagac atgcacgttg tcaggggaag     1140

agatggctgt gaatattctc ttggactgac cccgacaggc atattaatct ttgaaggagc     1200

taacaaaata ggcttattct tttggcctaa aattaccaaa atggatttta aaaagagcaa     1260

attgacactc gtggtggtcg aggatgatga tcagggacgt gagcaagagc acacgtttgt     1320

gttccggtta gacagtgcca ggacctgcaa acacctttgg aagtgtgcag ttgagcacca     1380

cgcattcttc cgactgcgga cgccaggaaa cagcaaatcc aatagatccg actttatcag     1440

gctgggctct cgcttcagat tcagtgggcg gacagaatat caagctacac atggctccag     1500

gttacgaaga accagcacct ttgagaggaa gcctagtaaa cgttatccat cccggagaca     1560

ttcaacgttc aaagcaagca acccagtgat agcagcccag ctctgctcta aaacaaatcc     1620

agaagtccat aattaccagc ctcaatatca tcctaatatc catcccagcc agccccggtg     1680

gcatcctcac tctccaaatg tcagctaccc gctcccttcc ccagtgctta gcagctcgga     1740

ccggttgcct tttggcattg aggagaatgg gggcacaccg ttcctcaccg cagcttcagg     1800

aaggcatcac caccagcacc agcatcagca tcagcaccag caccactcaa actacagcct     1860

ctcactgacc ctggagaaca aagaggggcc tctgaggtcc ccaaactcca gcagcaagtc     1920

ccttacaaaa ctgagtccag gaacacctgc cttgttcagt gaagccgctg cccatctaaa     1980

gaagctggaa ctggaaactg tgaaggctgc tggaccctgg cctcctctgc acatcaacat     2040

aaacaaggct gaagaaaaga aagtctcgga gaaaactctt cagactccac ttttgccttc     2100

ccctgttgcg gatcatgtga agtgtaacat tctgaaagcc cagttggaaa atgcttcccg     2160

agtgaacatc cagggtggaa aggaggaatc accgtttgta aatatcaata agaaatccag     2220

tcttcaggac gctagtgtaa gaagtcctat tcctattcgt gtggaaactg cccagccagc     2280

tgtggaaaag ccggaaatca agcctccccg agtgaggaag ttaacaagac agtatagttt     2340

tgatgaagac gacctccctc cagacctggc cgaggcagtg ggagtgacca catctacaac     2400

cacaaacacc acaacggccg ccacacaagt ctccgtgccg ctgccgtccc ccaaggtcca     2460

gaatgtcagc tcgcctcaca agtcagaagg caaaggcctg ctgtcccctg gggccaagag     2520

cccctctgac cgaggaggtg cctttaccct ggagccgggt gatcttctga tggatttcac     2580

agaagccact cctctggcag agcccgccag caacccccac tgtgcccact ctcgctgttc     2640

tcctccactc tctctcccca tgaaggaaga gaccactgga gtttgcatgt accctccaat     2700

caaaacgagg ctgataaaaa cattcccggt tgatacaatg aacccgtttc ctgatacttt     2760

caccacaggg ccacagttta ctgcagactt cagagacagt aaattacagt gctgtcctgg     2820

cccgacttcc ccgctgatcc cagcagcgac cctgaggcct ttgacagaga ccgtctccac     2880

agtgcagacc atttacacca cccggaaacc tgtttctctg gcagccagtg cagagacact     2940

ccggcaggaa ctggagagag agaagatgat gaaaagactg ttgatgaccg aactgtgaaa     3000

ttctcccctt gtcacctgga agatggcatg gtgccttctg tccgtcttct ttcttcgggc     3060

tttgtgtgct cactctagca cagcatacaa gtgtgtgctc tgttcgccca ggtctccatg     3120

gttagttgaa gccaatttct ggcttgactt ttatgggaaa agttatttta tgtctcctaa     3180

gcattagagt ttttctatta ctctatgtag ttgagacagg atttgataag tctaggaaaa     3240

gaaagatggg aaaacgggat tccttttcag aagtacctgt gtgtatctgt taataaccac     3300

aggggttaat atgatgtagg atcttttact atcaatttca accatttgat tttgtatgat     3360

tgaaacttgc accgagcttt gactgtttgt taaagagtca tttttaatga aagaataatt     3420

ctttattgct ggtttttcat ttacactgat aaatacacag atcttataaa gtctttaaca     3480

ttcatttgta ttcagatgtg agtagaagaa ctaaaaaaag aaagttacat atcactatga     3540

ctgaaggtac ttcagcttaa tctgaaatat aatttaactt gtgaactcct tggatatgat     3600

attatttgga ataaacagaa tttatcattg aacccaaagt aggaaatgat agcttacatt     3660

gtctaaaaat ccttacaagg ttaagatgat tcaatatcaa gaagattcag aaaattattt     3720

ctaaagttga tcgattcatg tcgtattgat agaatcttga ccagaagaaa ttttgctctt     3780

tttatatagt ttcaagaaat gtgtttttaa atttttatta atgcacttga acaactttgc     3840

aggaataaag caacccccta accacaaaat atccctctaa attagttccc tagctttctc     3900

aatgaataca cacatatttt tacatagcta tgatcgttgt gtacattctc ctttgtttta     3960

cttctcggcc taacacttgt ctcctcttgt caacacagat tctactctca ccaatttaaa     4020

tgtctttata tccatgtaac atgggtaacc tcacttcacc ccattattag atatttgagt     4080

tatatctaat ttttcactct tataaatagt gctgctatga atgtctgtaa aaaaaaaaaa     4140

ctgctccttc ttttggatta ttcccttagg aatatctcca aagagggatt acaaggtcaa     4200

agagcatgaa gtattttata gctcttgttt tatattgcca gattgctttc tagaaagatc     4260

caatctttgg gttggaagga ccttaaaggt catctagttt agcctcccca ccccctctga     4320

atgcttgaat cccctcgaca atttatgatg ccaccagcaa tgtataagca tttctgttta     4380

ccaatagctc tgccagtatt gggttttgcc atttttattt atttttgcta gtttaatagg     4440

tatgtatagt tgttcttgaa gagttgtttt atttcattaa ttgctagcaa ggctgagcac     4500

ttttccatgt gatgatttac tagttgtatt tccttgtgtg taaaatgttc attcatttct     4560

tatgaccact tgttaagagg aactgatctc atatatttgt atcagaactg tatttttatg     4620

ttatattgta tagtttgctc tcctgcccct ctccttaaaa ctgaatggtg ccaataattt     4680

gatactaatg actacaaaaa aaggtaatgc ctcatttact agtattgttg taaaatgagg     4740

aatgtatgtg aatattcaga taaccgagga ttaacccttt aagtgctgaa tctttaaaat     4800

tttaatatat ttttttttga gggaaatctt tctaaaatgt attacgcact tccctgcctt     4860

agtaaacaga gtatactgga gagtatttaa ccttttcttg atgagtcatg gtcatgatta     4920

taaacatcag ccccttttat accttggtac ggtgcagtga tatcattaag agctatcaat     4980

atgtgtaggg cttggcttgg ccttttatag gatattatgc tgttctcact gatggttttt     5040

tactgctctc tgctctgtca gtggagctat ccggggcaat tgtagcgttt gggtcctttt     5100

acccctatgt cccccggcta tacttttaaa acagctttag ctgttcttta tcttgtgcac     5160

atgatacaaa atatgttccc gtacaatatg gggctgtcac ttcttgccaa cccagcaccc     5220

tcttcctctt ctaacctgct ttctgaggct tctgctcttc acctcctgct cgctgatgga     5280

aacctccagg gcaaagctga aggtttcttg gggaagccag gaaagccagt atttcctatg     5340

tgtcagatct gcttggcttc caagaaggga tgcatgggct ttttggccag tgtttccagg     5400

aggctctggg cttcctgctt cttccccgct tcccccagag ttcacagatg ttgaagtttc     5460

tgaaggttga cgtcactgga agtctgacca caaacaagtt ggctgttact gtatttgaaa     5520

cccagtacct ttggcagctc acctctaacc agtaaaataa gaggattcca tggtttca       5578


<210>  22
<211>  518
<212>  PRT
<213>  homo sapiens

<400>  22

Met Leu Arg Phe Leu Arg Arg Thr Phe Gly Arg Arg Ser Met Gln Arg 
1               5                   10                  15      


Tyr Ala Arg Gly Ala Ala Gly Arg Gly Ala Ala Gly Leu Gly Asp Glu 
            20                  25                  30          


Arg Asp Gly Gly Pro Arg Gly Gly Pro Ala Ala Ala Ala Ser Ser Ser 
        35                  40                  45              


Ala Leu Pro Ala Ala Pro Gly Gly Ser Val Phe Pro Ala Gly Gly Gly 
    50                  55                  60                  


Pro Leu Leu Thr Gly Gly Ala Ala Val His Ile Ser Ala Ala Gly Ala 
65                  70                  75                  80  


Ala Lys Ala Thr Leu Tyr Cys Arg Val Phe Leu Leu Asp Gly Thr Glu 
                85                  90                  95      


Val Ser Val Asp Leu Pro Lys His Ala Lys Gly Gln Asp Leu Phe Asp 
            100                 105                 110         


Gln Ile Val Tyr His Leu Asp Leu Val Glu Thr Asp Tyr Phe Gly Leu 
        115                 120                 125             


Gln Phe Leu Asp Ser Ala Gln Val Ala His Trp Leu Asp His Ala Lys 
    130                 135                 140                 


Pro Ile Lys Lys Gln Met Lys Ile Gly Pro Ala Tyr Ala Leu His Phe 
145                 150                 155                 160 


Arg Val Lys Tyr Tyr Ser Ser Glu Pro Asn Asn Leu Arg Glu Glu Phe 
                165                 170                 175     


Thr Arg Tyr Leu Phe Val Leu Gln Leu Arg His Asp Ile Leu Ser Gly 
            180                 185                 190         


Lys Leu Lys Cys Pro Tyr Glu Thr Ala Val Glu Leu Ala Ala Leu Cys 
        195                 200                 205             


Leu Gln Ala Glu Leu Gly Glu Cys Glu Leu Pro Glu His Thr Pro Glu 
    210                 215                 220                 


Leu Val Ser Glu Phe Arg Phe Ile Pro Asn Gln Thr Glu Ala Met Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Gln Arg Trp Lys Glu Cys Arg Gly Lys Ser Pro Ala 
                245                 250                 255     


Gln Ala Glu Leu Ser Tyr Leu Asn Lys Ala Lys Trp Leu Glu Met Tyr 
            260                 265                 270         


Gly Val Asp Met His Val Val Arg Gly Arg Asp Gly Cys Glu Tyr Ser 
        275                 280                 285             


Leu Gly Leu Thr Pro Thr Gly Ile Leu Ile Phe Glu Gly Ala Asn Lys 
    290                 295                 300                 


Ile Gly Leu Phe Phe Trp Pro Lys Ile Thr Lys Met Asp Phe Lys Lys 
305                 310                 315                 320 


Ser Lys Leu Thr Leu Val Val Val Glu Asp Asp Asp Gln Gly Arg Glu 
                325                 330                 335     


Gln Glu His Thr Phe Val Phe Arg Leu Asp Ser Ala Arg Thr Cys Lys 
            340                 345                 350         


His Leu Trp Lys Cys Ala Val Glu His His Ala Phe Phe Arg Leu Arg 
        355                 360                 365             


Thr Pro Gly Asn Ser Lys Ser Asn Arg Ser Asp Phe Ile Arg Leu Gly 
    370                 375                 380                 


Ser Arg Phe Arg Phe Ser Gly Arg Thr Glu Tyr Gln Ala Thr His Gly 
385                 390                 395                 400 


Ser Arg Leu Arg Arg Thr Ser Thr Phe Glu Arg Lys Pro Ser Lys Arg 
                405                 410                 415     


Tyr Pro Ser Arg Arg His Ser Thr Phe Lys Ala Ser Asn Pro Val Ile 
            420                 425                 430         


Ala Ala Gln Leu Cys Ser Lys Thr Asn Pro Glu Val His Asn Tyr Gln 
        435                 440                 445             


Pro Gln Tyr His Pro Asn Ile His Pro Ser Gln Pro Arg Trp His Pro 
    450                 455                 460                 


His Ser Pro Asn Val Arg Pro Ser Phe Gln Asp Asp Arg Ser His Trp 
465                 470                 475                 480 


Lys Ala Ser Ala Ser Gly Asp Asp Ser His Phe Asp Tyr Val His Asp 
                485                 490                 495     


Gln Asn Gln Lys Asn Leu Gly Gly Met Gln Ser Met Met Tyr Arg Asp 
            500                 505                 510         


Lys Leu Met Thr Ala Leu 
        515             


<210>  23
<211>  900
<212>  PRT
<213>  homo sapiens

<400>  23

Met Leu Arg Phe Leu Arg Arg Thr Phe Gly Arg Arg Ser Met Gln Arg 
1               5                   10                  15      


Tyr Ala Arg Gly Ala Ala Gly Arg Gly Ala Ala Gly Leu Gly Asp Glu 
            20                  25                  30          


Arg Asp Gly Gly Pro Arg Gly Gly Pro Ala Ala Ala Ala Ser Ser Ser 
        35                  40                  45              


Ala Leu Pro Ala Ala Pro Gly Gly Ser Val Phe Pro Ala Gly Gly Gly 
    50                  55                  60                  


Pro Leu Leu Thr Gly Gly Ala Ala Val His Ile Ser Ala Ala Gly Ala 
65                  70                  75                  80  


Ala Lys Ala Thr Leu Tyr Cys Arg Val Phe Leu Leu Asp Gly Thr Glu 
                85                  90                  95      


Val Ser Val Asp Leu Pro Lys His Ala Lys Gly Gln Asp Leu Phe Asp 
            100                 105                 110         


Gln Ile Val Tyr His Leu Asp Leu Val Glu Thr Asp Tyr Phe Gly Leu 
        115                 120                 125             


Gln Phe Leu Asp Ser Ala Gln Val Ala His Trp Leu Asp His Ala Lys 
    130                 135                 140                 


Pro Ile Lys Lys Gln Met Lys Ile Gly Pro Ala Tyr Ala Leu His Phe 
145                 150                 155                 160 


Arg Val Lys Tyr Tyr Ser Ser Glu Pro Asn Asn Leu Arg Glu Glu Phe 
                165                 170                 175     


Thr Arg Tyr Leu Phe Val Leu Gln Leu Arg His Asp Ile Leu Ser Gly 
            180                 185                 190         


Lys Leu Lys Cys Pro Tyr Glu Thr Ala Val Glu Leu Ala Ala Leu Cys 
        195                 200                 205             


Leu Gln Ala Glu Leu Gly Glu Cys Glu Leu Pro Glu His Thr Pro Glu 
    210                 215                 220                 


Leu Val Ser Glu Phe Arg Phe Ile Pro Asn Gln Thr Glu Ala Met Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Gln Arg Trp Lys Glu Cys Arg Gly Lys Ser Pro Ala 
                245                 250                 255     


Gln Ala Glu Leu Ser Tyr Leu Asn Lys Ala Lys Trp Leu Glu Met Tyr 
            260                 265                 270         


Gly Val Asp Met His Val Val Arg Gly Arg Asp Gly Cys Glu Tyr Ser 
        275                 280                 285             


Leu Gly Leu Thr Pro Thr Gly Ile Leu Ile Phe Glu Gly Ala Asn Lys 
    290                 295                 300                 


Ile Gly Leu Phe Phe Trp Pro Lys Ile Thr Lys Met Asp Phe Lys Lys 
305                 310                 315                 320 


Ser Lys Leu Thr Leu Val Val Val Glu Asp Asp Asp Gln Gly Arg Glu 
                325                 330                 335     


Gln Glu His Thr Phe Val Phe Arg Leu Asp Ser Ala Arg Thr Cys Lys 
            340                 345                 350         


His Leu Trp Lys Cys Ala Val Glu His His Ala Phe Phe Arg Leu Arg 
        355                 360                 365             


Thr Pro Gly Asn Ser Lys Ser Asn Arg Ser Asp Phe Ile Arg Leu Gly 
    370                 375                 380                 


Ser Arg Phe Arg Phe Ser Gly Arg Thr Glu Tyr Gln Ala Thr His Gly 
385                 390                 395                 400 


Ser Arg Leu Arg Arg Thr Ser Thr Phe Glu Arg Lys Pro Ser Lys Arg 
                405                 410                 415     


Tyr Pro Ser Arg Arg His Ser Thr Phe Lys Ala Ser Asn Pro Val Ile 
            420                 425                 430         


Ala Ala Gln Leu Cys Ser Lys Thr Asn Pro Glu Val His Asn Tyr Gln 
        435                 440                 445             


Pro Gln Tyr His Pro Asn Ile His Pro Ser Gln Pro Arg Trp His Pro 
    450                 455                 460                 


His Ser Pro Asn Val Ser Tyr Pro Leu Pro Ser Pro Val Leu Ser Ser 
465                 470                 475                 480 


Ser Asp Arg Leu Pro Phe Gly Ile Glu Glu Asn Gly Gly Thr Pro Phe 
                485                 490                 495     


Leu Thr Ala Ala Ser Gly Arg His His His Gln His Gln His Gln His 
            500                 505                 510         


Gln His Gln His His Ser Asn Tyr Ser Leu Ser Leu Thr Leu Glu Asn 
        515                 520                 525             


Lys Glu Gly Pro Leu Arg Ser Pro Asn Ser Ser Ser Lys Ser Leu Thr 
    530                 535                 540                 


Lys Leu Ser Pro Gly Thr Pro Ala Leu Phe Ser Glu Ala Ala Ala His 
545                 550                 555                 560 


Leu Lys Lys Leu Glu Leu Glu Thr Val Lys Ala Ala Gly Pro Trp Pro 
                565                 570                 575     


Pro Leu His Ile Asn Ile Asn Lys Ala Glu Glu Lys Lys Val Ser Glu 
            580                 585                 590         


Lys Thr Leu Gln Thr Pro Leu Leu Pro Ser Pro Val Ala Asp His Val 
        595                 600                 605             


Lys Cys Asn Ile Leu Lys Ala Gln Leu Glu Asn Ala Ser Arg Val Asn 
    610                 615                 620                 


Ile Gln Gly Gly Lys Glu Glu Ser Pro Phe Val Asn Ile Asn Lys Lys 
625                 630                 635                 640 


Ser Ser Leu Gln Asp Ala Ser Val Arg Ser Pro Ile Pro Ile Arg Val 
                645                 650                 655     


Glu Thr Ala Gln Pro Ala Val Glu Lys Pro Glu Ile Lys Pro Pro Arg 
            660                 665                 670         


Val Arg Lys Leu Thr Arg Gln Tyr Ser Phe Asp Glu Asp Asp Leu Pro 
        675                 680                 685             


Pro Asp Leu Ala Glu Ala Val Gly Val Thr Thr Ser Thr Thr Thr Asn 
    690                 695                 700                 


Thr Thr Thr Ala Ala Thr Gln Val Ser Val Pro Leu Pro Ser Pro Lys 
705                 710                 715                 720 


Val Gln Asn Val Ser Ser Pro His Lys Ser Glu Gly Lys Gly Leu Leu 
                725                 730                 735     


Ser Pro Gly Ala Lys Ser Pro Ser Asp Arg Gly Gly Ala Phe Thr Leu 
            740                 745                 750         


Glu Pro Gly Asp Leu Leu Met Asp Phe Thr Glu Ala Thr Pro Leu Ala 
        755                 760                 765             


Glu Pro Ala Ser Asn Pro His Cys Ala His Ser Arg Cys Ser Pro Pro 
    770                 775                 780                 


Leu Ser Leu Pro Met Lys Glu Glu Thr Thr Gly Val Cys Met Tyr Pro 
785                 790                 795                 800 


Pro Ile Lys Thr Arg Leu Ile Lys Thr Phe Pro Val Asp Thr Met Asn 
                805                 810                 815     


Pro Phe Pro Asp Thr Phe Thr Thr Gly Pro Gln Phe Thr Ala Asp Phe 
            820                 825                 830         


Arg Asp Ser Lys Leu Gln Cys Cys Pro Gly Pro Thr Ser Pro Leu Ile 
        835                 840                 845             


Pro Ala Ala Thr Leu Arg Pro Leu Thr Glu Thr Val Ser Thr Val Gln 
    850                 855                 860                 


Thr Ile Tyr Thr Thr Arg Lys Pro Val Ser Leu Ala Ala Ser Ala Glu 
865                 870                 875                 880 


Thr Leu Arg Gln Glu Leu Glu Arg Glu Lys Met Met Lys Arg Leu Leu 
                885                 890                 895     


Met Thr Glu Leu 
            900 


<210>  24
<211>  188
<212>  PRT
<213>  homo sapiens

<400>  24

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  25
<211>  766
<212>  PRT
<213>  homo sapiens

<400>  25

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  26
<211>  189
<212>  PRT
<213>  homo sapiens

<400>  26

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  27
<211>  1068
<212>  PRT
<213>  homo sapiens

<400>  27

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  28
<211>  1210
<212>  PRT
<213>  homo sapiens

<400>  28

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  29
<211>  705
<212>  PRT
<213>  homo sapiens

<400>  29

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  30
<211>  628
<212>  PRT
<213>  homo sapiens

<400>  30

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  31
<211>  480
<212>  PRT
<213>  homo sapiens

<400>  31

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  32
<211>  480
<212>  PRT
<213>  homo sapiens

<400>  32

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  33
<211>  480
<212>  PRT
<213>  homo sapiens

<400>  33

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


