                         SEQUENCE LISTING

<110>  CSL Limited
       Ludwig Institute for Cancer Research Ltd
 
<120>  Method of treating cancer

<130>  516039

<150>  2013904620
<151>  2013-11-29

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210>  2
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Glu Leu Gln Phe Phe Ser Asn 
                325                 330                 


<210>  3
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
1               5                   10                  15      


Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            20                  25                  30          


Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        35                  40                  45              


Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    50                  55                  60                  


Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val 
65                  70                  75                  80  


Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu 
                85                  90                  95      


Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys 
            100                 105                 110         


Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu 
        115                 120                 125             


Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr 
    130                 135                 140                 


Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile 
145                 150                 155                 160 


Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro 
                165                 170                 175     


Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile 
            180                 185                 190         


Ile Val Val Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile 
        195                 200                 205             


Asn Lys Leu Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe 
    210                 215                 220                 


Glu Arg Glu Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg 
225                 230                 235                 240 


Val Gln Lys Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu 
                245                 250                 255     


Leu Arg Trp Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp 
            260                 265                 270         


Pro Asp Thr Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser 
        275                 280                 285             


Val Arg Arg Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn 
    290                 295                 300                 


Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe 
305                 310                 315                 320 


Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu 
                325                 330                 335     


Trp Thr Val Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val 
            340                 345                 350         


Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly 
        355                 360                 365             


Gln Tyr Arg Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu 
    370                 375                 380                 


Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val 
385                 390                 395                 400 


Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg 
                405                 410                 415     


Ser Ala Phe Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu 
            420                 425                 430         


Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val 
        435                 440                 445             


Thr Val Pro Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln 
    450                 455                 460                 


Ser Leu 
465     


<210>  4
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Gly Pro Val 
                325                 330 


