                         SEQUENCE LISTING

<110>  IFPEN
 
<120>  VARIANTS D'ENDOGLUCANASES A ACTIVITE AMELIOREE ET LEURS 
       UTILISATIONS

<130>  BFF

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1380
<212>  DNA
<213>  Trichoderma reesei

<400>  1
atggcgccct cagttacact gccgttgacc acggccatcc tggccattgc ccggctcgtc       60

gccgcccagc aaccgggtac cagcaccccc gaggtccatc ccaagttgac aacctacaag      120

tgtacaaagt ccggggggtg cgtggcccag gacacctcgg tggtccttga ctggaactac      180

cgctggatgc acgacgcaaa ctacaactcg tgcaccgtca acggcggcgt caacaccacg      240

ctctgccctg acgaggcgac ctgtggcaag aactgcttca tcgagggcgt cgactacgcc      300

gcctcgggcg tcacgacctc gggcagcagc ctcaccatga accagtacat gcccagcagc      360

tctggcggct acagcagcgt ctctcctcgg ctgtatctcc tggactctga cggtgagtac      420

gtgatgctga agctcaacgg ccaggagctg agcttcgacg tcgacctctc tgctctgccg      480

tgtggagaga acggctcgct ctacctgtct cagatggacg agaacggggg cgccaaccag      540

tataacacgg ccggtgccaa ctacgggagc ggctactgcg atgctcagtg ccccgtccag      600

acatggagga acggcaccct caacactagc caccagggct tctgctgcaa cgagatggat      660

atcctggagg gcaactcgag ggcgaatgcc ttgacccctc actcttgcac ggccacggcc      720

tgcgactctg ccggttgcgg cttcaacccc tatggcagcg gctacaaaag ctactacggc      780

cccggagata ccgttgacac ctccaagacc ttcaccatca tcacccagtt caacacggac      840

aacggctcgc cctcgggcaa ccttgtgagc atcacccgca agtaccagca aaacggcgtc      900

gacatcccca gcgcccagcc cggcggcgac accatctcgt cctgcccgtc cgcctcagcc      960

tacggcggcc tcgccaccat gggcaaggcc ctgagcagcg gcatggtgct cgtgttcagc     1020

atttggaacg acaacagcca gtacatgaac tggctcgaca gcggcaacgc cggcccctgc     1080

agcagcaccg agggcaaccc atccaacatc ctggccaaca accccaacac gcacgtcgtc     1140

ttctccaaca tccgctgggg agacattggg tctactacga actcgactgc gcccccgccc     1200

ccgcctgcgt ccagcacgac gttttcgact acacggagga gctcgacgac ttcgagcagc     1260

ccgagctgca cgcagactca ctgggggcag tgcggtggca ttgggtacag cgggtgcaag     1320

acgtgcacgt cgggcactac gtgccagtat agcaacgact actactcgca atgcctttaa     1380


<210>  2
<211>  459
<212>  PRT
<213>  Trichoderma reesei

<400>  2

Met Ala Pro Ser Val Thr Leu Pro Leu Thr Thr Ala Ile Leu Ala Ile 
1               5                   10                  15      


Ala Arg Leu Val Ala Ala Gln Gln Pro Gly Thr Ser Thr Pro Glu Val 
            20                  25                  30          


His Pro Lys Leu Thr Thr Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val 
        35                  40                  45              


Ala Gln Asp Thr Ser Val Val Leu Asp Trp Asn Tyr Arg Trp Met His 
    50                  55                  60                  


Asp Ala Asn Tyr Asn Ser Cys Thr Val Asn Gly Gly Val Asn Thr Thr 
65                  70                  75                  80  


Leu Cys Pro Asp Glu Ala Thr Cys Gly Lys Asn Cys Phe Ile Glu Gly 
                85                  90                  95      


Val Asp Tyr Ala Ala Ser Gly Val Thr Thr Ser Gly Ser Ser Leu Thr 
            100                 105                 110         


Met Asn Gln Tyr Met Pro Ser Ser Ser Gly Gly Tyr Ser Ser Val Ser 
        115                 120                 125             


Pro Arg Leu Tyr Leu Leu Asp Ser Asp Gly Glu Tyr Val Met Leu Lys 
    130                 135                 140                 


Leu Asn Gly Gln Glu Leu Ser Phe Asp Val Asp Leu Ser Ala Leu Pro 
145                 150                 155                 160 


Cys Gly Glu Asn Gly Ser Leu Tyr Leu Ser Gln Met Asp Glu Asn Gly 
                165                 170                 175     


Gly Ala Asn Gln Tyr Asn Thr Ala Gly Ala Asn Tyr Gly Ser Gly Tyr 
            180                 185                 190         


Cys Asp Ala Gln Cys Pro Val Gln Thr Trp Arg Asn Gly Thr Leu Asn 
        195                 200                 205             


Thr Ser His Gln Gly Phe Cys Cys Asn Glu Met Asp Ile Leu Glu Gly 
    210                 215                 220                 


Asn Ser Arg Ala Asn Ala Leu Thr Pro His Ser Cys Thr Ala Thr Ala 
225                 230                 235                 240 


Cys Asp Ser Ala Gly Cys Gly Phe Asn Pro Tyr Gly Ser Gly Tyr Lys 
                245                 250                 255     


Ser Tyr Tyr Gly Pro Gly Asp Thr Val Asp Thr Ser Lys Thr Phe Thr 
            260                 265                 270         


Ile Ile Thr Gln Phe Asn Thr Asp Asn Gly Ser Pro Ser Gly Asn Leu 
        275                 280                 285             


Val Ser Ile Thr Arg Lys Tyr Gln Gln Asn Gly Val Asp Ile Pro Ser 
    290                 295                 300                 


Ala Gln Pro Gly Gly Asp Thr Ile Ser Ser Cys Pro Ser Ala Ser Ala 
305                 310                 315                 320 


Tyr Gly Gly Leu Ala Thr Met Gly Lys Ala Leu Ser Ser Gly Met Val 
                325                 330                 335     


Leu Val Phe Ser Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu 
            340                 345                 350         


Asp Ser Gly Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser 
        355                 360                 365             


Asn Ile Leu Ala Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile 
    370                 375                 380                 


Arg Trp Gly Asp Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Ala Ser Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr 
                405                 410                 415     


Thr Ser Ser Ser Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly 
            420                 425                 430         


Gly Ile Gly Tyr Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys 
        435                 440                 445             


Gln Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu 
    450                 455                 


<210>  3
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  76B4

<400>  3
cagcaaccgg gttcggtgac ccccgaggtc catcccaagt tgcccacctg gcagtgtaca       60

aagtccgggg ggtgcgtgga gcaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

ttccacacct cggacaacac cacctcgtgc accacgtcct cgggcatcga ctcgacgctc      180

tgccctgacg cagcgacctg tgccgagaac tgcgtcgtgg agggcaccga ctacaccagc      240

tcgggcatcg agacctcggg cagcagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acgtctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgagggc gaattcgtac acccctcacc cctgcagtgc cacggactgc      660

gacaagggcg gttgcggctt caacccctat gctctcggcc aaaaaagcta ctggggcccc      720

ggaggcaccg ttgacacctc caagcccttc accatcacca cccagttcat cacgaacgac      780

ggcaccacca ccggcaccct ttccgaaatc cgccgccagt acatgcaaaa cggcaaggtg      840

atcgccaatg ccgtttcctc cactggcgtc aactccatca ccgaggactg gtgcacgtcc      900

gtcgacggct cggccgccac ctttggcggc ctcaccacca tgggcaaggc cctgggccgc      960

ggcatggtgc tcatcttcag catttggaac gacgccagcg gctttatgaa ctggctcgac     1020

agcggcaacg ccggcccctg cagcagcacc gagggcaacc cagacttgat caaggcccag     1080

aaccccacga cgcacgtcgt cttctccaac atccgctggg gagacattgg gtctactttc     1140

aagggttctg atggctcggt gacgacgacg acgtcgacta catcgaccaa gaccacgact     1200

tcgaccgcgc cggggccaac gcagactcac tatgggcagt gcggtggcca agggtggact     1260

gggcccacgg cttgcgcatc gccctacacg tgccaggttc tgaacccgtg gtactcgcaa     1320

tgcctttaa                                                             1329


<210>  4
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  76B4

<400>  4

Gln Gln Pro Gly Ser Val Thr Pro Glu Val His Pro Lys Leu Pro Thr 
1               5                   10                  15      


Trp Gln Cys Thr Lys Ser Gly Gly Cys Val Glu Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Phe His Thr Ser Asp Asn Thr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Ile Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Glu Asn Cys Val Val Glu Gly Thr Asp Tyr Thr Ser 
65                  70                  75                  80  


Ser Gly Ile Glu Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Arg Ala Asn 
        195                 200                 205             


Ser Tyr Thr Pro His Pro Cys Ser Ala Thr Asp Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Pro Tyr Ala Leu Gly Gln Lys Ser Tyr Trp Gly Pro 
225                 230                 235                 240 


Gly Gly Thr Val Asp Thr Ser Lys Pro Phe Thr Ile Thr Thr Gln Phe 
                245                 250                 255     


Ile Thr Asn Asp Gly Thr Thr Thr Gly Thr Leu Ser Glu Ile Arg Arg 
            260                 265                 270         


Gln Tyr Met Gln Asn Gly Lys Val Ile Ala Asn Ala Val Ser Ser Thr 
        275                 280                 285             


Gly Val Asn Ser Ile Thr Glu Asp Trp Cys Thr Ser Val Asp Gly Ser 
    290                 295                 300                 


Ala Ala Thr Phe Gly Gly Leu Thr Thr Met Gly Lys Ala Leu Gly Arg 
305                 310                 315                 320 


Gly Met Val Leu Ile Phe Ser Ile Trp Asn Asp Ala Ser Gly Phe Met 
                325                 330                 335     


Asn Trp Leu Asp Ser Gly Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly 
            340                 345                 350         


Asn Pro Asp Leu Ile Lys Ala Gln Asn Pro Thr Thr His Val Val Phe 
        355                 360                 365             


Ser Asn Ile Arg Trp Gly Asp Ile Gly Ser Thr Phe Lys Gly Ser Asp 
    370                 375                 380                 


Gly Ser Val Thr Thr Thr Thr Ser Thr Thr Ser Thr Lys Thr Thr Thr 
385                 390                 395                 400 


Ser Thr Ala Pro Gly Pro Thr Gln Thr His Tyr Gly Gln Cys Gly Gly 
                405                 410                 415     


Gln Gly Trp Thr Gly Pro Thr Ala Cys Ala Ser Pro Tyr Thr Cys Gln 
            420                 425                 430         


Val Leu Asn Pro Trp Tyr Ser Gln Cys Leu 
        435                 440         


<210>  5
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  105F11

<400>  5
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactggaa ctaccactgg      120

attcacacgg tcgatgggta cacatcgtgc accacatcgt ccggcgtcga cagcacgctc      180

tgccctgacg cggcgacctg tgcgaagaac tgcgtgatcg agccggccaa ctacaccagc      240

gccggcgtca cgacctcggg cgacagcctc accatgtacc agtacgttca gagcaacggc      300

gtctacacca acgcctctcc tcggctgtat ctcctgggcc ccgacaagaa ctacgtgatg      360

ctgaagctcc taggccagga gctgaccttc gacgtcgacc tctctgctct gccgtgtgga      420

gagaacggct cgctctacct gtctcagatg gacgagaacg ggggcgccaa ccagtataac      480

acggccggtg ccaactacgg gagcggctac tgcgatgctc agtgccccgt ccagacatgg      540

aggaacggca ccctcaacac tagccaccag ggctcgtgct gcaacgagat ggatatcctg      600

gaggccaact cgaaggcgga agccttcacc cctcacccct gcatcggcga caactgcgac      660

aagggcggtt gcggcttcaa cccctatgct ctcggccaaa aaagctactg gggccccgga      720

ggcaccgttg acacctccaa gcccttcacc atcaccaccc agttcatcac gaacgacggc      780

accaccaccg gcaccctttc cgaaatccgc cgccagtaca tgcaaaacgg caaggtgatc      840

gccaatgccg tttcctccac tggcgtcaac tccatcaccg aggactggtg cacgtccgtc      900

gacggctcgg ccgccacctt tggcggcctc accaccatgg gcaaggccct gggccgcggc      960

atggtgctcg tgttcagcat ttggaacgac aacagccagt acatgaactg gctcgacagc     1020

ggcaacgccg gcccctgcag cagcaccgag ggcaacccat ccaacatcct ggccaacaac     1080

cccaacacgc acgtcgtctt ctccaacatc cgctggggag acattgggtc tactacgaac     1140

tcgactgcgc ccccgccccc gcctgcgtcc agcacgacgt tttcgactac acggaggagc     1200

tcgacgactt cgagcagccc gagctgcacg cagactcact gggggcagtg cggtggcatt     1260

gggtacagcg ggtgcaagac gtgcacgtcg ggcactacgt gccagtatag caacgactac     1320

tactcgcaat gcctttaa                                                   1338


<210>  6
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  105F11

<400>  6

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr His Trp Ile His Thr Val Asp Gly Tyr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Val Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser 
65                  70                  75                  80  


Ala Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val 
                85                  90                  95      


Gln Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Leu Tyr Leu Leu 
            100                 105                 110         


Gly Pro Asp Lys Asn Tyr Val Met Leu Lys Leu Leu Gly Gln Glu Leu 
        115                 120                 125             


Thr Phe Asp Val Asp Leu Ser Ala Leu Pro Cys Gly Glu Asn Gly Ser 
    130                 135                 140                 


Leu Tyr Leu Ser Gln Met Asp Glu Asn Gly Gly Ala Asn Gln Tyr Asn 
145                 150                 155                 160 


Thr Ala Gly Ala Asn Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro 
                165                 170                 175     


Val Gln Thr Trp Arg Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser 
            180                 185                 190         


Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala 
        195                 200                 205             


Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys 
    210                 215                 220                 


Gly Phe Asn Pro Tyr Ala Leu Gly Gln Lys Ser Tyr Trp Gly Pro Gly 
225                 230                 235                 240 


Gly Thr Val Asp Thr Ser Lys Pro Phe Thr Ile Thr Thr Gln Phe Ile 
                245                 250                 255     


Thr Asn Asp Gly Thr Thr Thr Gly Thr Leu Ser Glu Ile Arg Arg Gln 
            260                 265                 270         


Tyr Met Gln Asn Gly Lys Val Ile Ala Asn Ala Val Ser Ser Thr Gly 
        275                 280                 285             


Val Asn Ser Ile Thr Glu Asp Trp Cys Thr Ser Val Asp Gly Ser Ala 
    290                 295                 300                 


Ala Thr Phe Gly Gly Leu Thr Thr Met Gly Lys Ala Leu Gly Arg Gly 
305                 310                 315                 320 


Met Val Leu Val Phe Ser Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn 
                325                 330                 335     


Trp Leu Asp Ser Gly Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn 
            340                 345                 350         


Pro Ser Asn Ile Leu Ala Asn Asn Pro Asn Thr His Val Val Phe Ser 
        355                 360                 365             


Asn Ile Arg Trp Gly Asp Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro 
    370                 375                 380                 


Pro Pro Pro Pro Ala Ser Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser 
385                 390                 395                 400 


Ser Thr Thr Ser Ser Ser Pro Ser Cys Thr Gln Thr His Trp Gly Gln 
                405                 410                 415     


Cys Gly Gly Ile Gly Tyr Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr 
            420                 425                 430         


Thr Cys Gln Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu 
        435                 440                 445 


<210>  7
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  107H12

<400>  7
cagcaaccgg gttcggtgac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactgggg ctaccactgg      120

attcacacgg tcgatgggta cacatcgtgc accacatcgt ccggcgtcga cagcacgctc      180

tgccctgacg cggcgacctg tgcgaagaac tgcgtgatcg agccggccaa ctacaccagc      240

gccggcgtca cgacctcggg cgacagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acctctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgaaggc ggaagccttc acccctcacc cctgcatcgg cgacaactgc      660

gacaagggcg gttgcggctt caactcgtat gcgcgcggca acaaaaacta ctgggcgccc      720

ggaggcaccc tcgacacctc caagcccttc accatggtga cccagttcat cacggacgac      780

ggcaccagct cgggcaagct tagccagatc gtgcgctcct acgtgcaaaa cggccagaag      840

gtcgccagcg ccgtgtccgg cggcgacagc atcaccgtcg agggctgctc gtcctccgac      900

gcctacggcg gcctcgtcgg tatgggcgag gccctgggcc gcggcatggt gctcgccatg      960

agcatttgga acgacgccag cggcttcatg aactggctcg acagcggcga caacggcccc     1020

tgcaacgaga ccgagggcga cccagccaac atcctggcca accaccccga ttcgcaggtc     1080

gtcctgtcca acatccgctg gggagacatt gactctactg ttcagctcta a              1131


<210>  8
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  107H12

<400>  8

Gln Gln Pro Gly Ser Val Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Gly Tyr His Trp Ile His Thr Val Asp Gly Tyr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Val Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser 
65                  70                  75                  80  


Ala Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Leu Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu 
        195                 200                 205             


Ala Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro 
225                 230                 235                 240 


Gly Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe 
                245                 250                 255     


Ile Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg 
            260                 265                 270         


Ser Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly 
        275                 280                 285             


Asp Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly 
    290                 295                 300                 


Leu Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Ala Met 
305                 310                 315                 320 


Ser Ile Trp Asn Asp Ala Ser Gly Phe Met Asn Trp Leu Asp Ser Gly 
                325                 330                 335     


Asp Asn Gly Pro Cys Asn Glu Thr Glu Gly Asp Pro Ala Asn Ile Leu 
            340                 345                 350         


Ala Asn His Pro Asp Ser Gln Val Val Leu Ser Asn Ile Arg Trp Gly 
        355                 360                 365             


Asp Ile Asp Ser Thr Val Gln Leu 
    370                 375     


<210>  9
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  154E4

<400>  9
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

actgctgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactgggg ctaccactgg      120

attcacacgg tcgatgggta cacatcgtgc accacatcgt ccggcgtcga cagcacgctc      180

tgccctgacg cggcgacctg tgcgaagaac tgcgtgatcg agccggccaa ctacaccagc      240

gccggcgtca cgacctcggg cgacagcctc accatgtacc agtacgttca gagcaacggc      300

gtctacacca acgcctctcc tcgggcctat ctcctgggcg ccgacggtga ctacgtgatg      360

ttcaagctcc tcaaccagga gctgagcttc gacgtcgacg tctctacgct gccgtgtgga      420

gagaacgcag cgctctactt ctctgagatg gacaagaccg ggggccggaa cgagcacaac      480

acgggcggtg ccaagtacgg gagcggctac tgcgatgctc agtgccccgt ccagacatgg      540

aacaacggca ccctcaacac tagccaccag ggctcgtgct gcaacgagat ggatatcctg      600

gaggccaact cgaaggcgga agccttcacc cctcacccct gcatcggcga caactgcgac      660

aagggcggtt gcggcttcaa ctcgtatgcg cgcggcaaca aaaactactg ggcgcccgga      720

ggcaccctcg acacctccaa gcccttcacc atggtgaccc agttcatcac ggacgacggc      780

accagctcgg gcaagcttag ccagatcgtg cgctcctacg tgcaaaacgg ccagaaggtc      840

gccagcgccg tgtccggcgg cgacagcatc accgtcgagg gctgctcgtc ctccgacgcc      900

tacggcggcc tcgtcggtat gggcgaggcc ctgggccgcg gcatggtgct cgtgttcagc      960

atttggaacg acaacagcca gtacatgaac tggctcgaca gcggcaacgc cggcccctgc     1020

agcagcaccg agggcaaccc atccaacatc ctggccaaca accccaacac gcacgtcgtc     1080

ttctccaaca tccgctgggg agacattggg tctactacga actcgactgc gcccccgccc     1140

ccgcctgcgt ccagcacgac gttttcgact acacggagga gctcgacgac ttcgagcagc     1200

ccgagctgca cgcagactca ctgggggcag tgcggtggca ttgggtacag cgggtgcaag     1260

acgtgcacgt cgggcactac gtgccagtat agcaacgact actactcgca atgcctttaa     1320


<210>  10
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  154E4

<400>  10

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Thr Ala Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Gly Tyr His Trp Ile His Thr Val Asp Gly Tyr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Val Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser 
65                  70                  75                  80  


Ala Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val 
                85                  90                  95      


Gln Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Ala Tyr Leu Leu 
            100                 105                 110         


Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu Leu 
        115                 120                 125             


Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala Ala 
    130                 135                 140                 


Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His Asn 
145                 150                 155                 160 


Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro 
                165                 170                 175     


Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser 
            180                 185                 190         


Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala 
        195                 200                 205             


Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys 
    210                 215                 220                 


Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro Gly 
225                 230                 235                 240 


Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe Ile 
                245                 250                 255     


Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg Ser 
            260                 265                 270         


Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly Asp 
        275                 280                 285             


Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly Leu 
    290                 295                 300                 


Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Val Phe Ser 
305                 310                 315                 320 


Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly Asn 
                325                 330                 335     


Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala 
            340                 345                 350         


Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp 
        355                 360                 365             


Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser 
    370                 375                 380                 


Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser 
385                 390                 395                 400 


Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr 
                405                 410                 415     


Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn 
            420                 425                 430         


Asp Tyr Tyr Ser Gln Cys Leu 
        435                 


<210>  11
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  202C12

<400>  11
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

atgcacgacg caaactacaa ctcgtgcacc gtcaacggcg gcgtcaacac cacgctctgc      180

cctgacgagg cgacctgtgg caagaactgc ttcatcgagg gcgtcgacta cgccgcctcg      240

ggcgtcacga cctcgggcag cagcctcacc ctgaggcagt tcgtcaagga cagcgagggc      300

aagaccaaca gcgtctctcc tcgggcctat ctcctgggcg ccgacggtga ctacgtgatg      360

ttcaagctcc tcaaccagga gctgagcttc gacgtcgacg tctctacgct gccgtgtgga      420

gagaacgcag cgctctactt ctctgagatg gacaagaccg ggggccggaa cgagcacaac      480

acgggcggtg ccgagtacgg gagcggctac tgcgatgctc agtgccccgt ccagacatgg      540

aacaacggca ccctcaacac tagccaccag ggctcgtgct gcaacgagat ggatatcctg      600

gaggccaact cgaaggcgga agccttcacc cctcacccct gcatcggcga caactgcgac      660

aagggcggtt gcggcttcaa ctcgtatgcg cgcggcaaca aaaactactg ggcgcccgga      720

ggcaccctcg acacctccaa gcccttcacc atggtgaccc agttcatcac ggacgacggc      780

accagctcgg gcaagcttag ccagatcgtg cgctcctacg tgcaaaacgg ccagaaggtc      840

gccagcgccg tgtccggcgg cgacagcatc accgtcgagg gctgctcgtc ctccgacgcc      900

tacggcggcc tcgtcggtat gggcgaggcc ctgggccgcg gcatggtgct cgccatgagc      960

atttggaacg acgccagcgg cttcatgaac tggctcgaca gcggcgacaa cggcccctgc     1020

aacgagaccg agggcaaccc atccaacatc ctggccaaca accccaacac gcacgtcgtc     1080

ttctccaaca tccgctgggg agacattggg tctactacga actcgactgc gcccccgccc     1140

ccgcctgcgt ccagcacgac gttttcgact acacggagga gctcgacgac ttcgagcagc     1200

ccgagctgca cgcagactca ctgggggcag tgcggtggca ttgggtacag cgggtgcaag     1260

acgtgcacgt cgggcactac gtgccagtat agcaacgact actactcgca atgcctttaa     1320


<210>  12
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  202C12

<400>  12

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Met His Asp Ala Asn Tyr Asn Ser 
        35                  40                  45              


Cys Thr Val Asn Gly Gly Val Asn Thr Thr Leu Cys Pro Asp Glu Ala 
    50                  55                  60                  


Thr Cys Gly Lys Asn Cys Phe Ile Glu Gly Val Asp Tyr Ala Ala Ser 
65                  70                  75                  80  


Gly Val Thr Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val Lys 
                85                  90                  95      


Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu Leu 
            100                 105                 110         


Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu Leu 
        115                 120                 125             


Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala Ala 
    130                 135                 140                 


Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His Asn 
145                 150                 155                 160 


Thr Gly Gly Ala Glu Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro 
                165                 170                 175     


Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser 
            180                 185                 190         


Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala 
        195                 200                 205             


Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys 
    210                 215                 220                 


Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro Gly 
225                 230                 235                 240 


Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe Ile 
                245                 250                 255     


Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg Ser 
            260                 265                 270         


Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly Asp 
        275                 280                 285             


Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly Leu 
    290                 295                 300                 


Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Ala Met Ser 
305                 310                 315                 320 


Ile Trp Asn Asp Ala Ser Gly Phe Met Asn Trp Leu Asp Ser Gly Asp 
                325                 330                 335     


Asn Gly Pro Cys Asn Glu Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala 
            340                 345                 350         


Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp 
        355                 360                 365             


Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser 
    370                 375                 380                 


Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser 
385                 390                 395                 400 


Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr 
                405                 410                 415     


Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn 
            420                 425                 430         


Asp Tyr Tyr Ser Gln Cys Leu 
        435                 


<210>  13
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272A9

<400>  13
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

atgcacgacg caaactacaa ctcgtgcacc gtcaacggcg gcgtcaacac cacgctctgc      180

cctgacgcgg cgacctgtgc gaagaactgc gtgatcgagc cggccaacta caccagcgcc      240

ggcgtcacga cctcgggcga cagcctcacc atgtaccagt acgttcagag caacggcgtc      300

tacaccaacg cctctcctcg gctgtatctc ctgggccccg acaagaacta cgtgatgctg      360

aagctcctag gccaggagct gagcttcgac gtcgacctct ctgctctgcc gtgtggagag      420

aacggcgccc tctacctgtc tgaaatgagc gccaccgggg gccgcaacga atataacacg      480

ggcggtgccg agtacgggag cggctactgc gatgctcagt gccccgtcat cgcctggaag      540

aacggcaccc tcaacactag cggcgcaagc tactgctgca acgagatgga tatcctggag      600

gccaactcga gggcgaattc gtacacccct cacccctgca gtgccacgga ctgcgacaag      660

ggcggttgcg gcttcaaccc ctatgctctc ggccaaaaaa gctactgggg ccccggaggc      720

accgttgaca cctccaagcc cttcaccatc accacccagt tcatcacgaa cgacggcacc      780

accaccggca ccctttccga aatccgccgc cagtacatgc aaaacggcaa ggtgatcgcc      840

aatgccgttt cctccactgg cgtcaactcc atcaccgagg actggtgcac gtccgtcgac      900

ggctcggccg ccacctttgg cggcctcacc accatgggca aggccctggg ccgcggcatg      960

gtgctcatct tcagcatttg gaacgacgcc agcggcttta tgaactggct cgacagcggc     1020

aacgccggcc cctgcagcag caccgagggc aacccagact tgatcaaggc ccagaacccc     1080

acgacgcacg tcgtcttctc caacatccgc tggggagaca ttgggtctac tttcaagggt     1140

tctgatggct cggtgacgac gacgacgtcg actacatcga ccaagaccac gacttcgacc     1200

gcgccggggc caacgcagac tcactatggg cagtgcggtg gccaagggtg gactgggccc     1260

acggcttgcg catcgcccta cacgtgccag gttctgaacc cgtggtactc gcaatgcctt     1320

taa                                                                   1323


<210>  14
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272A9

<400>  14

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Met His Asp Ala Asn Tyr Asn Ser 
        35                  40                  45              


Cys Thr Val Asn Gly Gly Val Asn Thr Thr Leu Cys Pro Asp Ala Ala 
    50                  55                  60                  


Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser Ala 
65                  70                  75                  80  


Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val Gln 
                85                  90                  95      


Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Leu Tyr Leu Leu Gly 
            100                 105                 110         


Pro Asp Lys Asn Tyr Val Met Leu Lys Leu Leu Gly Gln Glu Leu Ser 
        115                 120                 125             


Phe Asp Val Asp Leu Ser Ala Leu Pro Cys Gly Glu Asn Gly Ala Leu 
    130                 135                 140                 


Tyr Leu Ser Glu Met Ser Ala Thr Gly Gly Arg Asn Glu Tyr Asn Thr 
145                 150                 155                 160 


Gly Gly Ala Glu Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro Val 
                165                 170                 175     


Ile Ala Trp Lys Asn Gly Thr Leu Asn Thr Ser Gly Ala Ser Tyr Cys 
            180                 185                 190         


Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Arg Ala Asn Ser Tyr 
        195                 200                 205             


Thr Pro His Pro Cys Ser Ala Thr Asp Cys Asp Lys Gly Gly Cys Gly 
    210                 215                 220                 


Phe Asn Pro Tyr Ala Leu Gly Gln Lys Ser Tyr Trp Gly Pro Gly Gly 
225                 230                 235                 240 


Thr Val Asp Thr Ser Lys Pro Phe Thr Ile Thr Thr Gln Phe Ile Thr 
                245                 250                 255     


Asn Asp Gly Thr Thr Thr Gly Thr Leu Ser Glu Ile Arg Arg Gln Tyr 
            260                 265                 270         


Met Gln Asn Gly Lys Val Ile Ala Asn Ala Val Ser Ser Thr Gly Val 
        275                 280                 285             


Asn Ser Ile Thr Glu Asp Trp Cys Thr Ser Val Asp Gly Ser Ala Ala 
    290                 295                 300                 


Thr Phe Gly Gly Leu Thr Thr Met Gly Lys Ala Leu Gly Arg Gly Met 
305                 310                 315                 320 


Val Leu Ile Phe Ser Ile Trp Asn Asp Ala Ser Gly Phe Met Asn Trp 
                325                 330                 335     


Leu Asp Ser Gly Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro 
            340                 345                 350         


Asp Leu Ile Lys Ala Gln Asn Pro Thr Thr His Val Val Phe Ser Asn 
        355                 360                 365             


Ile Arg Trp Gly Asp Ile Gly Ser Thr Phe Lys Gly Ser Asp Gly Ser 
    370                 375                 380                 


Val Thr Thr Thr Thr Ser Thr Thr Ser Thr Lys Thr Thr Thr Ser Thr 
385                 390                 395                 400 


Ala Pro Gly Pro Thr Gln Thr His Tyr Gly Gln Cys Gly Gly Gln Gly 
                405                 410                 415     


Trp Thr Gly Pro Thr Ala Cys Ala Ser Pro Tyr Thr Cys Gln Val Leu 
            420                 425                 430         


Asn Pro Trp Tyr Ser Gln Cys Leu 
        435                 440 


<210>  15
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  278F10

<400>  15
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtgga gcaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

ttccacacct cggacaacac cacctcgtgc accacgtcct cgggcatcga ctcgacgctc      180

tgccctgacg cagcgacctg tgccgagaac tgcgtcgtgg agggcaccga ctacaccagc      240

tcgggcatcg agacctcggg cagcagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acgtctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgaaggc ggaagccttc acccctcacc cctgcatcgg cgacaactgc      660

gacaagggcg gttgcggctt caactcgtat gcgcgcggca acaaaaacta ctgggcgccc      720

ggaggcaccc tcgacacctc caagcccttc accatggtga cccagttcat cacggacgac      780

ggcaccagct cgggcaacct tgtgagcatc acccgcaagt accagcaaaa cggcgtcgac      840

atccccagcg cccagcccgg cggcgacacc atctcgtcct gcccgtccgc ctcagcctac      900

ggcggcctcg ccaccatggg caaggccctg agcagcggca tggtgctcgt gttcagcatt      960

tggaacgaca acagccagta catgaactgg ctcgacagcg gcaacgccgg cccctgcagc     1020

agcaccgagg gcaacccatc caacatcctg gccaacaacc ccaacacgca cgtcgtcttc     1080

tccaacatcc gctggggaga cattgggtct actacgaact cgactgcgcc cccgcccccg     1140

cctgcgtcca gcacgacgtt ttcgactaca cggaggagct cgacgacttc gagcagcccg     1200

agctgcacgc agactcactg ggggcagtgc ggtggcattg ggtacagcgg gtgcaagacg     1260

tgcacgtcgg gcactacgtg ccagtatagc aacgactact actcgcaatg cctttaa        1317


<210>  16
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278F10

<400>  16

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Glu Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Phe His Thr Ser Asp Asn Thr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Ile Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Glu Asn Cys Val Val Glu Gly Thr Asp Tyr Thr Ser 
65                  70                  75                  80  


Ser Gly Ile Glu Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu 
        195                 200                 205             


Ala Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro 
225                 230                 235                 240 


Gly Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe 
                245                 250                 255     


Ile Thr Asp Asp Gly Thr Ser Ser Gly Asn Leu Val Ser Ile Thr Arg 
            260                 265                 270         


Lys Tyr Gln Gln Asn Gly Val Asp Ile Pro Ser Ala Gln Pro Gly Gly 
        275                 280                 285             


Asp Thr Ile Ser Ser Cys Pro Ser Ala Ser Ala Tyr Gly Gly Leu Ala 
    290                 295                 300                 


Thr Met Gly Lys Ala Leu Ser Ser Gly Met Val Leu Val Phe Ser Ile 
305                 310                 315                 320 


Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly Asn Ala 
                325                 330                 335     


Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala Asn 
            340                 345                 350         


Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp Ile 
        355                 360                 365             


Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser Ser 
    370                 375                 380                 


Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser Pro 
385                 390                 395                 400 


Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr Ser 
                405                 410                 415     


Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn Asp 
            420                 425                 430         


Tyr Tyr Ser Gln Cys Leu 
        435             


<210>  17
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  293B2

<400>  17
cagcaaccgg gttcggtgac ccccgaggtc catcccaagt tgcccacctg gcagtgtaca       60

aagtccgggg ggtgcgtgga gcaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

ttccacacct cggacaacac cacctcgtgc accacgtcct cgggcatcga ctcgacgctc      180

tgccctgacg cagcgacctg tgccgagaac tgcgtcgtgg agggcaccga ctacaccagc      240

tcgggcatcg agacctcggg cagcagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acgtctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgaaggc ggaagccttc acccctcacc cctgcatcgg cgacaactgc      660

gacaagggcg gttgcggctt caactcgtat gcgcgcggca acaaaaacta ctgggcgccc      720

ggaggcaccc tcgacacctc caagcccttc accatggtga cccagttcat cacggacgac      780

ggcaccagct cgggcaagct tagccagatc gtgcgctcct acgtgcaaaa cggccagaag      840

gtcgccagcg ccgtgtccgg cggcgacagc atcaccgtcg agggctgctc gtcctccgac      900

gcctacggcg gcctcgtcgg tatgggcgag gccctgggcc gcggcatggt gctcgtgttc      960

agcatttgga acgacaacag ccagtacatg aactggctcg acagcggcaa cgccggcccc     1020

tgcagcagca ccgagggcaa cccatccaac atcctggcca acaaccccaa cacgcacgtc     1080

gtcttctcca acatccgctg gggagacatt gggtctacta cgaactcgac tgcgcccccg     1140

cccccgcctg cgtccagcac gacgttttcg actacacgga ggagctcgac gacttcgagc     1200

agcccgagct gcacgcagac tcactggggg cagtgcggtg gcattgggta cagcgggtgc     1260

aagacgtgca cgtcgggcac tacgtgccag tatagcaacg actactactc gcaatgcctt     1320

taa                                                                   1323


<210>  18
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  293B2

<400>  18

Gln Gln Pro Gly Ser Val Thr Pro Glu Val His Pro Lys Leu Pro Thr 
1               5                   10                  15      


Trp Gln Cys Thr Lys Ser Gly Gly Cys Val Glu Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Phe His Thr Ser Asp Asn Thr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Ile Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Glu Asn Cys Val Val Glu Gly Thr Asp Tyr Thr Ser 
65                  70                  75                  80  


Ser Gly Ile Glu Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu 
        195                 200                 205             


Ala Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro 
225                 230                 235                 240 


Gly Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe 
                245                 250                 255     


Ile Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg 
            260                 265                 270         


Ser Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly 
        275                 280                 285             


Asp Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly 
    290                 295                 300                 


Leu Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Val Phe 
305                 310                 315                 320 


Ser Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly 
                325                 330                 335     


Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu 
            340                 345                 350         


Ala Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly 
        355                 360                 365             


Asp Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala 
    370                 375                 380                 


Ser Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly 
                405                 410                 415     


Tyr Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser 
            420                 425                 430         


Asn Asp Tyr Tyr Ser Gln Cys Leu 
        435                 440 


<210>  19
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  309A11

<400>  19
cagcaaccgg gttcggtgac ccccgaggtc catcccaagt tgcccacctg gcagtgtaca       60

aagtccgggg ggtgcgtgga gcaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

ttccacacct cggacaacac cacctcgtgc accacgtcct cgggcatcga ctcgacgctc      180

tgccctgacg cagcgacctg tgccgagaac tgcgtcgtgg agggcaccga ctacaccagc      240

tcgggcatcg agacctcggg cagcagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acgtctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgaaggc ggaagccttc acccctcacc cctgcatcgg cgacaactgc      660

gacaagggcg gttgcggctt caactcgtat gcgcgcggca acaaaaacta ctgggcgccc      720

ggaggcaccc tcgacacctc caagcccttc accatggtga cccagttcat cacggacgac      780

ggcaccagct cgggcaagct tagccagatc gtgcgctcct acgtgcaaaa cggccagaag      840

gtcgccagcg ccgtgtccgg cggcgacagc atcaccgtcg agggctgctc gtccgcctca      900

gcctacggcg gcctcgccac catgggcaag gccctgagca gcggcatggt gctcgtgttc      960

agcatttgga acgacaacag ccagtacatg aactggctcg acagcggcaa cgccggcccc     1020

tgcagcagca ccgagggcaa cccatccaac atcctggcca acaaccccaa cacgcacgtc     1080

gtcttctcca acatccgctg gggagacatt gggtctacta cgaactcgac tgcgcccccg     1140

cccccgcctg cgtccagcac gacgttttcg actacacgga ggagctcgac gacttcgagc     1200

agcccgagct gcacgcagac tcactggggg cagtgcggtg gcattgggta cagcgggtgc     1260

aagacgtgca cgtcgggcac tacgtgccag tatagcaacg actactactc gcaatgcctt     1320

taa                                                                   1323


<210>  20
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  309A1

<400>  20

Gln Gln Pro Gly Ser Val Thr Pro Glu Val His Pro Lys Leu Pro Thr 
1               5                   10                  15      


Trp Gln Cys Thr Lys Ser Gly Gly Cys Val Glu Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Phe His Thr Ser Asp Asn Thr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Ile Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Glu Asn Cys Val Val Glu Gly Thr Asp Tyr Thr Ser 
65                  70                  75                  80  


Ser Gly Ile Glu Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu 
        195                 200                 205             


Ala Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro 
225                 230                 235                 240 


Gly Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe 
                245                 250                 255     


Ile Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg 
            260                 265                 270         


Ser Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly 
        275                 280                 285             


Asp Ser Ile Thr Val Glu Gly Cys Ser Ser Ala Ser Ala Tyr Gly Gly 
    290                 295                 300                 


Leu Ala Thr Met Gly Lys Ala Leu Ser Ser Gly Met Val Leu Val Phe 
305                 310                 315                 320 


Ser Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly 
                325                 330                 335     


Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu 
            340                 345                 350         


Ala Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly 
        355                 360                 365             


Asp Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala 
    370                 375                 380                 


Ser Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly 
                405                 410                 415     


Tyr Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser 
            420                 425                 430         


Asn Asp Tyr Tyr Ser Gln Cys Leu 
        435                 440 


<210>  21
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8

<400>  21
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

atgcacgacg caaactacaa ctcgtgcacc gtcaacggcg gcgtcaacac cacgctctgc      180

cctgacgagg cgacctgtgg caagaactgc ttcatcgagg gcgtcgacta cgccgcctcg      240

ggcgtcacga cctcgggcag cagcctcacc ctgaggcagt tcgtcaagga cagcgagggc      300

aagaccaaca gcgtctctcc tcgggcctat ctcctgggcg ccgacggtga ctacgtgatg      360

ttcaagctcc tcaaccagga gctgagcttc gacgtcgacg tctctacgct gccgtgtgga      420

gagaacgcag cgctctactt ctctgagatg gacaagaccg ggggccgcaa cgaatataac      480

acgggcggtg ccgagtacgg gagcggctac tgcgatgctc agtgccccgt ccagacatgg      540

aacaacggca ccctcaacac tagccaccag ggctcgtgct gcaacgagat ggatatcctg      600

gaggccaact cgaaggcgga agccttcacc cctcacccct gcatcggcga caactgcgac      660

aagggcggtt gcggcttcaa ctcgtatgcg cgcggcaaca aaaactactg ggcgcccgga      720

ggcaccctcg acacctccaa gcccttcacc atggtgaccc agttcatcac ggacgacggc      780

accagctcgg gcaagcttag ccagatcgtg cgctcctacg tgcaaaacgg ccagaaggtc      840

gccagcgccg tgtccggcgg cgacagcatc accgtcgagg gctgctcgtc ctccgacgcc      900

tacggcggcc tcgtcggtat gggcgaggcc ctgggccgcg gcatggtgct cgtgttcagc      960

atttggaacg acaacagcca gtacatgaac tggctcgaca gcggcaacgc cggcccctgc     1020

agcagcaccg agggcaaccc atccaacatc ctggccaaca accccaacac gcacgtcgtc     1080

ttctccaaca tccgctgggg agacattggg tctactacga actcgactgc gcccccgccc     1140

ccgcctgcgt ccagcacgac gttttcgact acacggagga gctcgacgac ttcgagcagc     1200

ccgagctgca cgcagactca ctgggggcag tgcggtggca ttgggtacag cgggtgcaag     1260

acgtgcacgt cgggcactac gtgccagtat agcaacgact actactcgca atgcctttaa     1320


<210>  22
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8

<400>  22

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Met His Asp Ala Asn Tyr Asn Ser 
        35                  40                  45              


Cys Thr Val Asn Gly Gly Val Asn Thr Thr Leu Cys Pro Asp Glu Ala 
    50                  55                  60                  


Thr Cys Gly Lys Asn Cys Phe Ile Glu Gly Val Asp Tyr Ala Ala Ser 
65                  70                  75                  80  


Gly Val Thr Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val Lys 
                85                  90                  95      


Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu Leu 
            100                 105                 110         


Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu Leu 
        115                 120                 125             


Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala Ala 
    130                 135                 140                 


Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu Tyr Asn 
145                 150                 155                 160 


Thr Gly Gly Ala Glu Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro 
                165                 170                 175     


Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser 
            180                 185                 190         


Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala 
        195                 200                 205             


Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys 
    210                 215                 220                 


Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro Gly 
225                 230                 235                 240 


Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe Ile 
                245                 250                 255     


Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg Ser 
            260                 265                 270         


Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly Asp 
        275                 280                 285             


Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly Leu 
    290                 295                 300                 


Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Val Phe Ser 
305                 310                 315                 320 


Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly Asn 
                325                 330                 335     


Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala 
            340                 345                 350         


Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp 
        355                 360                 365             


Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser 
    370                 375                 380                 


Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser 
385                 390                 395                 400 


Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr 
                405                 410                 415     


Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn 
            420                 425                 430         


Asp Tyr Tyr Ser Gln Cys Leu 
        435                 


<210>  23
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  92A12

<400>  23
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

aagtccgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

atgcacgacg caaactacaa ctcgtgcacc gtcaacggcg gcgtcaacac cacgctctgc      180

cctgacgcgg cgacctgtgc gaagaactgc gtgatcgagc cggccaacta caccagcgcc      240

ggcgtcacga cctcgggcga cagcctcacc atgtaccagt acgttcagag caacggcgtc      300

tacaccaacg cctctcctcg ggcctatctc ctgggcgccg acggtgacta cgtgatgttc      360

aagctcctca accaggagct gagcttcgac gtcgacgtct ctacgctgcc gtgtggagag      420

aacgcagcgc tctacttctc tgagatggac aagaccgggg gccggaacga gcacaacacg      480

ggcggtgcca agtacgggag cggctactgc gatgctcagt gccccgtcca gacatggaac      540

aacggcaccc tcaacactag ccaccagggc tcgtgctgca acgagatgga tatcctggag      600

gccaactcga aggcggaagc cttcacccct cacccctgca tcggcgacaa ctgcgacaag      660

ggcggttgcg gcttcaactc gtatgcgcgc ggcaacaaaa actactgggc gcccggaggc      720

accctcgaca cctccaagcc cttcaccatg gtgacccagt tcatcacgga cgacggcacc      780

agctcgggca agcttagcca gatcgtgcgc tcctacgtgc aaaacggcca gaaggtcgcc      840

agcgccgtgt ccggcggcga cagcatcacc gtcgagggct gctcgtcctc cgacgcctac      900

ggcggcctcg tcggtatggg cgaggccctg ggccgcggca tggtgctcgt gttcagcatt      960

tggaacgaca acagccagta catgaactgg ctcgacagcg gcaacgccgg cccctgcagc     1020

agcaccgagg gcaacccatc caacatcctg gccaacaacc ccaacacgca cgtcgtcttc     1080

tccaacatcc gctggggaga cattgggtct actacgaact cgactgcgcc cccgcccccg     1140

cctgcgtcca gcacgacgtt ttcgactaca cggaggagct cgacgacttc gagcagcccg     1200

agctgcacgc agactcactg ggggcagtgc ggtggcattg ggtacagcgg gtgcaagacg     1260

tgcacgtcgg gcactacgtg ccagtatagc aacgactact actcgcaatg cctttaa        1317


<210>  24
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  92A12

<400>  24

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Lys Ser Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Met His Asp Ala Asn Tyr Asn Ser 
        35                  40                  45              


Cys Thr Val Asn Gly Gly Val Asn Thr Thr Leu Cys Pro Asp Ala Ala 
    50                  55                  60                  


Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser Ala 
65                  70                  75                  80  


Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val Gln 
                85                  90                  95      


Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Ala Tyr Leu Leu Gly 
            100                 105                 110         


Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu Leu Ser 
        115                 120                 125             


Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala Ala Leu 
    130                 135                 140                 


Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His Asn Thr 
145                 150                 155                 160 


Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro Val 
                165                 170                 175     


Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser Cys 
            180                 185                 190         


Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala Phe 
        195                 200                 205             


Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys Gly 
    210                 215                 220                 


Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro Gly Gly 
225                 230                 235                 240 


Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe Ile Thr 
                245                 250                 255     


Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg Ser Tyr 
            260                 265                 270         


Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly Asp Ser 
        275                 280                 285             


Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly Leu Val 
    290                 295                 300                 


Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Val Phe Ser Ile 
305                 310                 315                 320 


Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly Asn Ala 
                325                 330                 335     


Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala Asn 
            340                 345                 350         


Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp Ile 
        355                 360                 365             


Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser Ser 
    370                 375                 380                 


Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser Pro 
385                 390                 395                 400 


Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr Ser 
                405                 410                 415     


Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn Asp 
            420                 425                 430         


Tyr Tyr Ser Gln Cys Leu 
        435             


<210>  25
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  240H12

<400>  25
cagcaaccgg gtaccagcac ccccgaggtc catcccaagt tgacaaccta caagtgtaca       60

actgctgggg ggtgcgtggc ccaggacacc tcggtggtcc ttgactgggg ctaccactgg      120

attcacacgg tcgatgggta cacatcgtgc accacatcgt ccggcgtcga cagcacgctc      180

tgccctgacg cggcgacctg tgcgaagaac tgcgtgatcg agccggccaa ctacaccagc      240

gccggcgtca cgacctcggg cgacagcctc accatgtacc agtacgttca gagcaacggc      300

gtctacacca acgcctctcc tcgggcctat ctcctgggcg ccgacggtga ctacgtgatg      360

ttcaagctcc tcaaccagga gctgagcttc gacgtcgacg tctctacgct gccgtgtgga      420

gagaacgcag cgctctactt ctctgagatg gacaagaccg ggggccggaa cgagcacaac      480

acgggcggtg ccaagtacgg gagcggctac tgcgatgctc agtgccccgt ccagacatgg      540

aacaacggca ccctcaacac tagccaccag ggctcgtgct gcaacgagat ggatatcctg      600

gaggccaact cgaaggcgga agccttcacc cctcacccct gcatcggcga caactgcgac      660

aagggcggtt gcggcttcaa ctcgtatgcg cgcggcaaca aaaactactg ggcgcccgga      720

ggcaccctcg acacctccaa gcccttcacc atggtgaccc agttcatcac ggacgacggc      780

accagctcgg gcaagcttag ccagatcgtg cgctcctacg tgcaaaacgg ccagaaggtc      840

gccagcgccg tgtccggcgg cgacagcatc accgtcgagg gctgctcgtc cgcctcagcc      900

tacggcggcc tcgccaccat gggcaaggcc ctgagcagcg gcatggtgct cgtgttcagc      960

atttggaacg acaacagcca gtacatgaac tggctcgaca gcggcaacgc cggcccctgc     1020

agcagcaccg agggcaaccc atccaacatc ctggccaaca accccaacac gcacgtcgtc     1080

ttctccaaca tccgctgggg agacattggg tctactacga actcgactgc gcccccgccc     1140

ccgcctgcgt ccagcacgac gttttcgact acacggagga gctcgacgac ttcgagcagc     1200

ccgagctgca cgcagactca ctgggggcag tgcggtggca ttgggtacag cgggtgcaag     1260

acgtgcacgt cgggcactac gtgccagtat agcaacgact actactcgca atgcctttaa     1320


<210>  26
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  240H12

<400>  26

Gln Gln Pro Gly Thr Ser Thr Pro Glu Val His Pro Lys Leu Thr Thr 
1               5                   10                  15      


Tyr Lys Cys Thr Thr Ala Gly Gly Cys Val Ala Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Gly Tyr His Trp Ile His Thr Val Asp Gly Tyr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Val Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser 
65                  70                  75                  80  


Ala Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val 
                85                  90                  95      


Gln Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Ala Tyr Leu Leu 
            100                 105                 110         


Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu Leu 
        115                 120                 125             


Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala Ala 
    130                 135                 140                 


Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His Asn 
145                 150                 155                 160 


Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro 
                165                 170                 175     


Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly Ser 
            180                 185                 190         


Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu Ala 
        195                 200                 205             


Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly Cys 
    210                 215                 220                 


Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro Gly 
225                 230                 235                 240 


Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe Ile 
                245                 250                 255     


Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg Ser 
            260                 265                 270         


Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly Asp 
        275                 280                 285             


Ser Ile Thr Val Glu Gly Cys Ser Ser Ala Ser Ala Tyr Gly Gly Leu 
    290                 295                 300                 


Ala Thr Met Gly Lys Ala Leu Ser Ser Gly Met Val Leu Val Phe Ser 
305                 310                 315                 320 


Ile Trp Asn Asp Asn Ser Gln Tyr Met Asn Trp Leu Asp Ser Gly Asn 
                325                 330                 335     


Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro Ser Asn Ile Leu Ala 
            340                 345                 350         


Asn Asn Pro Asn Thr His Val Val Phe Ser Asn Ile Arg Trp Gly Asp 
        355                 360                 365             


Ile Gly Ser Thr Thr Asn Ser Thr Ala Pro Pro Pro Pro Pro Ala Ser 
    370                 375                 380                 


Ser Thr Thr Phe Ser Thr Thr Arg Arg Ser Ser Thr Thr Ser Ser Ser 
385                 390                 395                 400 


Pro Ser Cys Thr Gln Thr His Trp Gly Gln Cys Gly Gly Ile Gly Tyr 
                405                 410                 415     


Ser Gly Cys Lys Thr Cys Thr Ser Gly Thr Thr Cys Gln Tyr Ser Asn 
            420                 425                 430         


Asp Tyr Tyr Ser Gln Cys Leu 
        435                 


<210>  27
<211>  1131
<212>  DNA
<213>  Chaetomium globosum

<400>  27
cagcaaccgg gttcggtgac ccccgaggtc catcccaagt tgcccacctg gcagtgtaca       60

aagtccgggg ggtgcgtgga gcaggacacc tcggtggtcc ttgactggaa ctaccgctgg      120

ttccacacct cggacaacac cacctcgtgc accacgtcct cgggcatcga ctcgacgctc      180

tgccctgacg cagcgacctg tgccgagaac tgcgtcgtgg agggcaccga ctacaccagc      240

tcgggcatcg agacctcggg cagcagcctc accctgaggc agttcgtcaa ggacagcgag      300

ggcaagacca acagcgtctc tcctcgggcc tatctcctgg gcgccgacgg tgactacgtg      360

atgttcaagc tcctcaacca ggagctgagc ttcgacgtcg acgtctctac gctgccgtgt      420

ggagagaacg cagcgctcta cttctctgag atggacaaga ccgggggccg gaacgagcac      480

aacacgggcg gtgccaagta cgggagcggc tactgcgatg ctcagtgccc cgtccagaca      540

tggaacaacg gcaccctcaa cactagccac cagggctcgt gctgcaacga gatggatatc      600

ctggaggcca actcgaaggc ggaagccttc acccctcacc cctgcatcgg cgacaactgc      660

gacaagggcg gttgcggctt caactcgtat gcgcgcggca acaaaaacta ctgggcgccc      720

ggaggcaccc tcgacacctc caagcccttc accatggtga cccagttcat cacggacgac      780

ggcaccagct cgggcaagct tagccagatc gtgcgctcct acgtgcaaaa cggccagaag      840

gtcgccagcg ccgtgtccgg cggcgacagc atcaccgtcg agggctgctc gtcctccgac      900

gcctacggcg gcctcgtcgg tatgggcgag gccctgggcc gcggcatggt gctcgccatg      960

agcatttgga acgacgccag cggcttcatg aactggctcg acagcggcga caacggcccc     1020

tgcaacgaga ccgagggcga cccagccaac atcctggcca accaccccga ttcgcaggtc     1080

gtcctgtcca acatccgctg gggagacatt gactctactg ttcagctcta a              1131


<210>  28
<211>  376
<212>  PRT
<213>  Chaetomium globosum

<400>  28

Gln Gln Pro Gly Ser Val Thr Pro Glu Val His Pro Lys Leu Pro Thr 
1               5                   10                  15      


Trp Gln Cys Thr Lys Ser Gly Gly Cys Val Glu Gln Asp Thr Ser Val 
            20                  25                  30          


Val Leu Asp Trp Asn Tyr Arg Trp Phe His Thr Ser Asp Asn Thr Thr 
        35                  40                  45              


Ser Cys Thr Thr Ser Ser Gly Ile Asp Ser Thr Leu Cys Pro Asp Ala 
    50                  55                  60                  


Ala Thr Cys Ala Glu Asn Cys Val Val Glu Gly Thr Asp Tyr Thr Ser 
65                  70                  75                  80  


Ser Gly Ile Glu Thr Ser Gly Ser Ser Leu Thr Leu Arg Gln Phe Val 
                85                  90                  95      


Lys Asp Ser Glu Gly Lys Thr Asn Ser Val Ser Pro Arg Ala Tyr Leu 
            100                 105                 110         


Leu Gly Ala Asp Gly Asp Tyr Val Met Phe Lys Leu Leu Asn Gln Glu 
        115                 120                 125             


Leu Ser Phe Asp Val Asp Val Ser Thr Leu Pro Cys Gly Glu Asn Ala 
    130                 135                 140                 


Ala Leu Tyr Phe Ser Glu Met Asp Lys Thr Gly Gly Arg Asn Glu His 
145                 150                 155                 160 


Asn Thr Gly Gly Ala Lys Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys 
                165                 170                 175     


Pro Val Gln Thr Trp Asn Asn Gly Thr Leu Asn Thr Ser His Gln Gly 
            180                 185                 190         


Ser Cys Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Lys Ala Glu 
        195                 200                 205             


Ala Phe Thr Pro His Pro Cys Ile Gly Asp Asn Cys Asp Lys Gly Gly 
    210                 215                 220                 


Cys Gly Phe Asn Ser Tyr Ala Arg Gly Asn Lys Asn Tyr Trp Ala Pro 
225                 230                 235                 240 


Gly Gly Thr Leu Asp Thr Ser Lys Pro Phe Thr Met Val Thr Gln Phe 
                245                 250                 255     


Ile Thr Asp Asp Gly Thr Ser Ser Gly Lys Leu Ser Gln Ile Val Arg 
            260                 265                 270         


Ser Tyr Val Gln Asn Gly Gln Lys Val Ala Ser Ala Val Ser Gly Gly 
        275                 280                 285             


Asp Ser Ile Thr Val Glu Gly Cys Ser Ser Ser Asp Ala Tyr Gly Gly 
    290                 295                 300                 


Leu Val Gly Met Gly Glu Ala Leu Gly Arg Gly Met Val Leu Ala Met 
305                 310                 315                 320 


Ser Ile Trp Asn Asp Ala Ser Gly Phe Met Asn Trp Leu Asp Ser Gly 
                325                 330                 335     


Asp Asn Gly Pro Cys Asn Glu Thr Glu Gly Asp Pro Ala Asn Ile Leu 
            340                 345                 350         


Ala Asn His Pro Asp Ser Gln Val Val Leu Ser Asn Ile Arg Trp Gly 
        355                 360                 365             


Asp Ile Asp Ser Thr Val Gln Leu 
    370                 375     


<210>  29
<211>  1323
<212>  DNA
<213>  Aspergillus fumigatus

<400>  29
cagcaaccgg ccgcgagttc tgctggtaac cccaagttga caacctacaa gtgtacaact       60

gctggggggt gcgtggccca ggacacctcg gtggtccttg actggggcta ccactggatt      120

cacacggtcg atgggtacac atcgtgcacc acatcgtccg gcgtcgacag cacgctctgc      180

cctgacgcgg cgacctgtgc gaagaactgc gtgatcgagc cggccaacta caccagcgcc      240

ggcgtcacga cctcgggcga cagcctcacc atgtaccagt acgttcagag caacggcgtc      300

tacaccaacg cctctcctcg gctgtatctc ctgggccccg acaagaacta cgtgatgctg      360

aagctcctag gccaggagct gaccttcgac gtcgacctct ctacactgcc gtgtggagag      420

aacggcgccc tctacctgtc tgaaatgagc gccaccgggg gccgcaacga atataacacg      480

ggcggtgccg agtacgggag cggctactgc gatgctcagt gccccgtcat cgcctggaag      540

aacggcaccc tcaacactag cggcgcaagc tactgctgca acgagatgga tatcctggag      600

gccaactcga gggcgaattc gtacacccct cacccctgca gtgccacgga ctgcgacaag      660

ggcggttgcg gcttcaaccc ctatgctctc ggccaaaaaa gctactgggg ccccggaggc      720

accgttgaca cctccaagcc cttcaccatc accacccagt tcatcacgaa cgacggcacc      780

accaccggca ccctttccga aatccgccgc cagtacatgc aaaacggcaa ggtgatcgcc      840

aatgccgttt cctccactgg cgtcaactcc atcaccgagg actggtgcac gtccgtcgac      900

ggctcggccg ccacctttgg cggcctcacc accatgggca aggccctggg ccgcggcatg      960

gtgctcatct tcagcatttg gaacgacgcc agcggcttta tgaactggct cgacagcggc     1020

aacgccggcc cctgcagcag caccgagggc aacccagact tgatcaaggc ccagaacccc     1080

acgacgcacg tcgtcttctc caacatccgc tggggagaca ttgggtctac tttcaagggt     1140

tctgatggct cggtgacgac gacgacgtcg actacatcga ccaagaccac gacttcgacc     1200

gcgccggggc caacgcagac tcactatggg cagtgcggtg gccaagggtg gactgggccc     1260

acggcttgcg catcgcccta cacgtgccag gttctgaacc cgtggtactc gcaatgcctt     1320

taa                                                                   1323


<210>  30
<211>  440
<212>  PRT
<213>  Aspergillus fumigatus

<400>  30

Gln Gln Pro Ala Ala Ser Ser Ala Gly Asn Pro Lys Leu Thr Thr Tyr 
1               5                   10                  15      


Lys Cys Thr Thr Ala Gly Gly Cys Val Ala Gln Asp Thr Ser Val Val 
            20                  25                  30          


Leu Asp Trp Gly Tyr His Trp Ile His Thr Val Asp Gly Tyr Thr Ser 
        35                  40                  45              


Cys Thr Thr Ser Ser Gly Val Asp Ser Thr Leu Cys Pro Asp Ala Ala 
    50                  55                  60                  


Thr Cys Ala Lys Asn Cys Val Ile Glu Pro Ala Asn Tyr Thr Ser Ala 
65                  70                  75                  80  


Gly Val Thr Thr Ser Gly Asp Ser Leu Thr Met Tyr Gln Tyr Val Gln 
                85                  90                  95      


Ser Asn Gly Val Tyr Thr Asn Ala Ser Pro Arg Leu Tyr Leu Leu Gly 
            100                 105                 110         


Pro Asp Lys Asn Tyr Val Met Leu Lys Leu Leu Gly Gln Glu Leu Thr 
        115                 120                 125             


Phe Asp Val Asp Leu Ser Thr Leu Pro Cys Gly Glu Asn Gly Ala Leu 
    130                 135                 140                 


Tyr Leu Ser Glu Met Ser Ala Thr Gly Gly Arg Asn Glu Tyr Asn Thr 
145                 150                 155                 160 


Gly Gly Ala Glu Tyr Gly Ser Gly Tyr Cys Asp Ala Gln Cys Pro Val 
                165                 170                 175     


Ile Ala Trp Lys Asn Gly Thr Leu Asn Thr Ser Gly Ala Ser Tyr Cys 
            180                 185                 190         


Cys Asn Glu Met Asp Ile Leu Glu Ala Asn Ser Arg Ala Asn Ser Tyr 
        195                 200                 205             


Thr Pro His Pro Cys Ser Ala Thr Asp Cys Asp Lys Gly Gly Cys Gly 
    210                 215                 220                 


Phe Asn Pro Tyr Ala Leu Gly Gln Lys Ser Tyr Trp Gly Pro Gly Gly 
225                 230                 235                 240 


Thr Val Asp Thr Ser Lys Pro Phe Thr Ile Thr Thr Gln Phe Ile Thr 
                245                 250                 255     


Asn Asp Gly Thr Thr Thr Gly Thr Leu Ser Glu Ile Arg Arg Gln Tyr 
            260                 265                 270         


Met Gln Asn Gly Lys Val Ile Ala Asn Ala Val Ser Ser Thr Gly Val 
        275                 280                 285             


Asn Ser Ile Thr Glu Asp Trp Cys Thr Ser Val Asp Gly Ser Ala Ala 
    290                 295                 300                 


Thr Phe Gly Gly Leu Thr Thr Met Gly Lys Ala Leu Gly Arg Gly Met 
305                 310                 315                 320 


Val Leu Ile Phe Ser Ile Trp Asn Asp Ala Ser Gly Phe Met Asn Trp 
                325                 330                 335     


Leu Asp Ser Gly Asn Ala Gly Pro Cys Ser Ser Thr Glu Gly Asn Pro 
            340                 345                 350         


Asp Leu Ile Lys Ala Gln Asn Pro Thr Thr His Val Val Phe Ser Asn 
        355                 360                 365             


Ile Arg Trp Gly Asp Ile Gly Ser Thr Phe Lys Gly Ser Asp Gly Ser 
    370                 375                 380                 


Val Thr Thr Thr Thr Ser Thr Thr Ser Thr Lys Thr Thr Thr Ser Thr 
385                 390                 395                 400 


Ala Pro Gly Pro Thr Gln Thr His Tyr Gly Gln Cys Gly Gly Gln Gly 
                405                 410                 415     


Trp Thr Gly Pro Thr Ala Cys Ala Ser Pro Tyr Thr Cys Gln Val Leu 
            420                 425                 430         


Asn Pro Trp Tyr Ser Gln Cys Leu 
        435                 440 


