                         SEQUENCE LISTING

<110>  ONCODIAG
 
<120>  Methods for the prognosis, diagnosis and screening of bladder 
       cancer

<130>  BEP130696EP

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc     60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc    120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc    180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg    240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc    300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac    360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag    420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac    480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc    540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc    600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc    660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg    720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg    780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac    840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg    900

gacggcacac cctacgttac cgtgctcaag tcctggatca gtgagagtgt ggaggccgac    960

gtgcgcctcc gcctggccaa tgtgtcggag cgggacgggg gcgagtacct ctgtcgagcc   1020

accaatttca taggcgtggc cgagaaggcc ttttggctga gcgttcacgg gccccgagca   1080

gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg catcctcagc   1140

tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct ctgccgcctg   1200

cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc ccgcttcccg   1260

ctcaagcgac aggtgtccct ggagtccaac gcgtccatga gctccaacac accactggtg   1320

cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg ccaatgtctc cgagctcgag   1380

ctgcctgccg accccaaatg ggagctgtct cgggcccggc tgaccctggg caagcccctt   1440

ggggagggct gcttcggcca ggtggtcatg gcggaggcca tcggcattga caaggaccgg   1500

gccgccaagc ctgtcaccgt agccgtgaag atgctgaaag acgatgccac tgacaaggac   1560

ctgtcggacc tggtgtctga gatggagatg atgaagatga tcgggaaaca caaaaacatc   1620

atcaacctgc tgggcgcctg cacgcagggc gggcccctgt acgtgctggt ggagtacgcg   1680

gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct ggactactcc   1740

ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt gtcctgtgcc   1800

taccaggtgg cccggggcat ggagtacttg gcctcccaga agtgcatcca cagggacctg   1860

gctgcccgca atgtgctggt gaccgaggac aacgtgatga agatcgcaga cttcgggctg   1920

gcccgggacg tgcacaacct cgactactac aagaagacaa ccaacggccg gctgcccgtg   1980

aagtggatgg cgcctgaggc cttgtttgac cgagtctaca ctcaccagag tgacgtctgg   2040

tcctttgggg tcctgctctg ggagatcttc acgctggggg gctccccgta ccccggcatc   2100

cctgtggagg agctcttcaa gctgctgaag gagggccacc gcatggacaa gcccgccaac   2160

tgcacacacg acctgtacat gatcatgcgg gagtgctggc atgccgcgcc ctcccagagg   2220

cccaccttca agcagctggt ggaggacctg gaccgtgtcc ttaccgtgac gtccaccgac   2280

gagtacctgg acctgtcggc gcctttcgag cagtactccc cgggtggcca ggacaccccc   2340

agctccagct cctcagggga cgactccgtg tttgcccacg acctgctgcc cccggcccca   2400

cccagcagtg ggggctcgcg gacgtga                                       2427


<210>  2
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp 
305                 310                 315                 320 


Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr 
                325                 330                 335     


Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp 
            340                 345                 350         


Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala 
        355                 360                 365             


Asp Glu Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly 
    370                 375                 380                 


Phe Phe Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu 
385                 390                 395                 400 


Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile 
                405                 410                 415     


Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser 
            420                 425                 430         


Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly 
        435                 440                 445             


Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp 
    450                 455                 460                 


Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu 
465                 470                 475                 480 


Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile 
                485                 490                 495     


Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu 
            500                 505                 510         


Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met 
        515                 520                 525             


Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu 
    530                 535                 540                 


Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala 
545                 550                 555                 560 


Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly 
                565                 570                 575     


Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr 
            580                 585                 590         


Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu 
        595                 600                 605             


Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
    610                 615                 620                 


Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu 
625                 630                 635                 640 


Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly 
                645                 650                 655     


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val 
            660                 665                 670         


Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
        675                 680                 685             


Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu 
    690                 695                 700                 


Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn 
705                 710                 715                 720 


Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala 
                725                 730                 735     


Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg 
            740                 745                 750         


Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro 
        755                 760                 765             


Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser 
    770                 775                 780                 


Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro 
785                 790                 795                 800 


Pro Ser Ser Gly Gly Ser Arg Thr 
                805             


<210>  3
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  3
ttttttcgtc gttgtttttc gcgcgattcg ttgtttatta gttattatgt cggatttcgc     60

ggttaacgcg tagttggatg ggattatttc ggat                                 94


<210>  4
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  4
tagtttcgtc gggtattggg ttttagatat tgcgcggttt tttcggagta gtaagttaaa     60

gaaagttttt agtgtcggcg a                                               81


<210>  5
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  5
gacggtgtgg atggtttcga ggtttaaaaa gaaagcgttt aacggttgga cgtatatttc     60

gttaggtttt ttggaaacgg tgtcggtgtt gtagagt                              97


<210>  6
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  6
gcgcggggtt attttagtcg cggagggcgc gtaggttgtt tttcgttttt acgttttcgt     60

ttttttgtat ttatttgtgt tatagttttt tgtgttgttg cgacgatttg               110


<210>  7
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  7
aggtttgttt tgaggatttt tgagtttttt ttttatttta tttcgttggg agtttagggg     60

aattagggtt tgggcgtttg gattttcggg ttttttagaa cgttttttag agagaggaat    120

tgagaggaga agg                                                       133


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
cagtggcggt ggtggtgagg                                                 20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
atgggccggt gcggggagca                                                 20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
caggatgggc cggtgcgggc                                                 20


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
atgtctttgc agccgaggag gag                                             23


<210>  12
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
agctgaggat gcctgcatac acactgca                                        28


<210>  13
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
accccgtagc tgaggatgcc tgctc                                           25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
cctttgggga tctgtccact cctga                                           25


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
gttgtccagg tgagccaggc cat                                             23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
ttttttcgtc gttgtttttc gc                                              22


<210>  17
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
atccgaaata atcccatcca actac                                           25


<210>  18
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  probe

<400>  18
attatgtcgg atttcgc                                                    17


<210>  19
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
tagtttcgtc gggtattggg ttt                                             23


<210>  20
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  20
tcgccgacac taaaaacttt ctttaa                                          26


<210>  21
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  probe

<400>  21
agatattgcg cggtttt                                                    17


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  22
gacggtgtgg atggtttcga                                                 20


<210>  23
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  23
actctacaac accgacaccg tttc                                            24


<210>  24
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  probel

<400>  24
agcgtttaac ggttggac                                                   18


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  25
gcgcggggtt attttagtcg                                                 20


<210>  26
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  26
caaatcgtcg caacaacaca aa                                              22


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  27
cgtaaaaacg aaaaacaac                                                  19


<210>  28
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  28
aggtttgttt tgaggatttt tgagttt                                         27


<210>  29
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  29
ccttctcctc tcaattcctc tctctaa                                         27


<210>  30
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  probe

<400>  30
cgtttggatt ttcgggttt                                                  19


<210>  31
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  31
cctttgggga tctgtccact cctgatgctg ttatgggcaa ccctaaggtg aaggctcatg     60

gcaagaaagt gctcggtgcc tttagtgatg gcctggctca cctggacaac               110


<210>  32
<211>  155
<212>  DNA
<213>  Homo sapiens

<400>  32
tcgcgacgga ctttgagcgc ggcgctcctc tcccgccccg gcgcctttcc ttcccctccc     60

cgaccctccc gggcctcccc cgacccggcc cctgggccct ccccagccct gccccgcccc    120

aggcgcgcct cctccgcctc gaccttccac ttccc                               155


<210>  33
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer forward

<400>  33
cccttcacct tccagctc                                                   18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  34
agcgctgcct gaaactcg                                                   18


<210>  35
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Probe mutation 77CT of TERT

<400>  35
cccggaaggg gct                                                        13


<210>  36
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  probe mutation 99CT of TERT

<400>  36
cccggaaggg gtc                                                        13


