                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC
 
<120> GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC 
      HEART FAILURE

<130> 043214-079691-PCT

<140>
<141>

<150> 61/902,928
<151> 2013-11-12

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 407
<212> PRT
<213> Homo sapiens

<400> 1
Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210> 2
<211> 383
<212> PRT
<213> Homo sapiens

<400> 2
Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg 
        275                 280                 285             


Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp 
    290                 295                 300                 


Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln 
305                 310                 315                 320 


Cys Glu Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln 
                325                 330                 335     


Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys 
            340                 345                 350         


Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile 
        355                 360                 365             


Tyr Gly Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380             


<210> 3
<211> 4260
<212> DNA
<213> Homo sapiens

<400> 3
tccccgcccc ccagtcctcc ctcccctccc ctccagcatg gtgctcgcgg ccccgctgct       60

gctgggcttc ctgctcctcg ccctggagct gcggccccgg ggggaggcgg ccgagggccc      120

cgcggcggcg gcggcggcgg cggcggcggc ggcagcggcg ggggtcgggg gggagcgctc      180

cagccggcca gccccgtccg tggcgcccga gccggacggc tgccccgtgt gcgtttggcg      240

gcagcacagc cgcgagctgc gcctagagag catcaagtcg cagatcttga gcaaactgcg      300

gctcaaggag gcgcccaaca tcagccgcga ggtggtgaag cagctgctgc ccaaggcgcc      360

gccgctgcag cagatcctgg acctacacga cttccagggc gacgcgctgc agcccgagga      420

cttcctggag gaggacgagt accacgccac caccgagacc gtcattagca tggcccagga      480

gacggaccca gcagtacaga cagatggcag ccctctctgc tgccattttc acttcagccc      540

caaggtgatg ttcacaaagg tactgaaggc ccagctgtgg gtgtacctac ggcctgtacc      600

ccgcccagcc acagtctacc tgcagatctt gcgactaaaa cccctaactg gggaagggac      660

cgcaggggga gggggcggag gccggcgtca catccgtatc cgctcactga agattgagct      720

gcactcacgc tcaggccatt ggcagagcat cgacttcaag caagtgctac acagctggtt      780

ccgccagcca cagagcaact ggggcatcga gatcaacgcc tttgatccca gtggcacaga      840

cctggctgtc acctccctgg ggccgggagc cgaggggctg catccattca tggagcttcg      900

agtcctagag aacacaaaac gttcccggcg gaacctgggt ctggactgcg acgagcactc      960

aagcgagtcc cgctgctgcc gatatcccct cacagtggac tttgaggctt tcggctggga     1020

ctggatcatc gcacctaagc gctacaaggc caactactgc tccggccagt gcgagtacat     1080

gttcatgcaa aaatatccgc atacccattt ggtgcagcag gccaatccaa gaggctctgc     1140

tgggccctgt tgtaccccca ccaagatgtc cccaatcaac atgctctact tcaatgacaa     1200

gcagcagatt atctacggca agatccctgg catggtggtg gatcgctgtg gctgctctta     1260

aggtggggga tagaggatgc ctcccccaca gaccctaccc caagacccct agccctgccc     1320

ccatcccccc aagccctaga gctccctcca ctcttcccgc gaacatcaca ccgttccccg     1380

accaagccgt gtgcaataca acagagggag gcaggtggga attgagggtg aggggtttgg     1440

gggaaagggg aagcaggggc atagtcaggg tggggagtgt ttgaagtttg cagatgagaa     1500

ggtttgacaa aaagacagag agatgtagag acagtgatag agacagagga acaaaaagag     1560

cagcagtgag aaggcaaaga gagaggcaga agagacagac gaggcagaga caaaacactg     1620

agaaagagac tgaaatggag taataaatga aagccccaca ccaagcctcc tttcttccac     1680

tggcaaggtg aggggcttgg tatagtttgg ggagatcccc tgactattca gtaggagaag     1740

aaatcaaaaa tccattcttt tctccttctc tccctccaac agtggccagg ggaaggggaa     1800

gtgagggcag gggcaaaaag atttgggaat ttttatttat ttatttattg tgacttttca     1860

tttttttggt atttggcttt actggaatag gagggcccct gcccactgtg ccccgtttat     1920

cccttattcc ccaaaccctg ctctccccaa cacctactca cttaagcact tgtataaagc     1980

ctccagggtt gggaatggga gtaaagggca agagggcgga cacatgaagt ttagtttcta     2040

acccatcatc accctaactc aaccttttct gagccaaatg gcttgaattg aagccagttg     2100

tcatggaaat agtaagaggt tagggtttaa gagctgggga tgcgggggtg ggagagagaa     2160

ccctcaacat ccaggatcta tataatgaga gctactttaa accctcaggt ccaccctcat     2220

gatgctgagt tatttagcca gagggtgcag cctgcttatg cccaaattcc ctcagccaag     2280

agagagacca aagagcctct ggaatggccc tgctcccagc ctctatcttc aggtcaatta     2340

gagagagtat agagacccca gagtcccctg ggtctggaaa gcgttaggag aggtcaagaa     2400

aggagcagta aggaggctga aggttacagg gcatttgaat ccaaatcact gctctgggct     2460

agggaataga gccagcagac caaggtggga aggattctgg aagggggaca ttttagtctc     2520

ctaaccccaa agctcagggt ggaagagggg agaacaagga agcagagtgt ataattattt     2580

tttcctttta tttttggaat ctaacagtac ctggcagcag ggaggggaaa gtacagtggg     2640

gaaaagcatc tgacaaggcc agttagaaca gaggatggga aggatggaga ctcccgggct     2700

tggaaggcta ggaagcaggc agagactggt tgccatttca agtcactagc taggcccatt     2760

cattcctccc acaaccctga cccattctcc tctggactca ctgtgcctca gtttcttccc     2820

ctcaatggaa tgagaaatga cagcacccgc cacagccaag agatgaattc tgagcactta     2880

ccacgggcac tttatggaca taaaatacct ctcgctgtgg gacagataac cagggcacca     2940

gagtagtggt gaagagatgt gaggcttaag aggagtcaca ggcttcagag tacaagttcc     3000

cctctgcctc ccagctggac agtgcctaga agccaaggag ttgagaatct cctgatccac     3060

accctatcct tacttcacca ccaggcctct tggctccagg caagagctta gaggatgtca     3120

ggagaggtgg gggtaagaat cttcagcaaa actgtcactc taagtagagc cagcagttac     3180

gggtctgata aaaacagtac tgaactaaag taaagcccaa gctggtgagc aaaactggat     3240

ggctcattct tcccaagagc atgactctcc cccttggcca gttggtggaa ggggcaaagg     3300

tatgtgacca cccttgagaa ggtgatgttg gtgagcttta acatcttatt cctattctta     3360

tagtgagaaa gtgaaacaag atctttcagt agaggaatgg gcagggctgt taggctcttc     3420

agcttgcctt cacccatata gcagctatgc taaccccaag cctctctggc cctgttcttc     3480

atccttcctt ctgccccaat cctgaaggac aagacacacc cggccatcaa caccactcac     3540

atttccttgg tggaaggaaa ggaacagaga agtgaagaac agatacctcc ctccaaggtc     3600

aaatgcctcg tgatcttggc agagtaggga ttgggcaata agcatcaggt atcttccctc     3660

tacagattct agagagctgg ggcattaaat atgggggaca cttagaatac agctccttaa     3720

ataccaccaa ataaagacct ttgtgtgtgt gtggtgggtg gggggggggc aggggtcttt     3780

ctcttatgaa cataaatctg tgagctgaag tctcattccc ctgttcctcc ctacccccaa     3840

agaggcacag agtgaaggga cttggggggc acagctcagc aacccagtgg gagttagcac     3900

cccctcccac cttatgatgt gtgtggacct ggccagtgcc cctctgaaca tatcattatt     3960

agtgtaatta tcatttattt tgtgtatttg tcacattgtg tgcatgacag cctttgttaa     4020

gggtgtctga ggagtatgga gctgacaggg gcattggaat gccaggaaag aacttcttca     4080

actgagatca aggcttcctg gagggaacca ctgcaaaaag gccatcaggc agttttcaag     4140

ttatgtgaca gagggcaaag acggccatag ggtgctctga gttttgggat ggtcacatga     4200

cacaatccag cacttgaacc tgaaaaaaaa aataaaagcg gtcaaagagt ttagaattca     4260


<210> 4
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
tcgtcttggc cttttggct                                                    19


<210> 5
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
tccaggtggt ctagcaggtt ct                                                22


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
agggagaaca cggcatcatt                                                   20


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
gacagcacct tcaggagat                                                    19


<210> 8
<211> 109
<212> PRT
<213> Homo sapiens

<400> 8
Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210> 9
<211> 274
<212> PRT
<213> Homo sapiens

<400> 9
Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg 
        


<210> 10
<211> 2525
<212> DNA
<213> Homo sapiens

<400> 10
gggaagtcgg tgccgctgcc gtctctgcgt tcgccatgcg tcccggggcg ccagggccac       60

tctggcctct gccctggggg gccctggctt gggccgtggg cttcgtgagc tccatgggct      120

cggggaaccc cgcgcccggt ggtgtttgct ggctccagca gggccaggag gccacctgca      180

gcctggtgct ccagactgat gtcacccggg ccgagtgctg tgcctccggc aacattgaca      240

ccgcctggtc caacctcacc cacccgggga acaagatcaa cctcctcggc ttcttgggcc      300

ttgtccactg ccttccctgc aaagattcgt gcgacggcgt ggagtgcggc ccgggcaagg      360

cgtgccgcat gctggggggc cgcccgcgct gcgagtgcgc gcccgactgc tcggggctcc      420

cggcgcggct gcaggtctgc ggctcagacg gcgccaccta ccgcgacgag tgcgagctgc      480

gcgccgcgcg ctgccgcggc cacccggacc tgagcgtcat gtaccggggc cgctgccgca      540

agtcctgtga gcacgtggtg tgcccgcggc cacagtcgtg cgtcgtggac cagacgggca      600

gcgcccactg cgtggtgtgt cgagcggcgc cctgccctgt gccctccagc cccggccagg      660

agctttgcgg caacaacaac gtcacctaca tctcctcgtg ccacatgcgc caggccacct      720

gcttcctggg ccgctccatc ggcgtgcgcc acgcgggcag ctgcgcaggc acccctgagg      780

agccgccagg tggtgagtct gcagaagagg aagagaactt cgtgtgagcc tgcaggacag      840

gcctgggcct ggtgcccgag gccccccatc atcccctgtt atttattgcc acagcagagt      900

ctaatttata tgccacggac actccttaga gcccggattc ggaccacttg gggatcccag      960

aacctccctg acgatatcct ggaaggactg aggaagggag gcctgggggc cggctggtgg     1020

gtgggataga cctgcgttcc ggacactgag cgcctgattt agggcccttc tctaggatgc     1080

cccagcccct accctaagac ctattgccgg ggaggattcc acacttccgc tcctttgggg     1140

ataaacctat taattattgc tactatcaag agggctgggc attctctgct ggtaattcct     1200

gaagaggcat gactgctttt ctcagcccca agcctctagt ctgggtgtgt acggagggtc     1260

tagcctgggt gtgtacggag ggtctagcct gggtgagtac ggagggtcta gcctgggtga     1320

gtacggaggg tctagcctgg gtgagtacgg agggtctagc ctgggtgtgt atggaggatc     1380

tagcctgggt gagtatggag ggtctagcct gggtgagtat ggagggtcta gcctgggtgt     1440

gtatggaggg tctagcctgg gtgagtatgg agggtctagc ctgggtgtgt atggagggtc     1500

tagcctgggt gagtatggag ggtctagcct gggtgtgtac ggagggtcta gtctgagtgc     1560

gtgtggggac ctcagaacac tgtgacctta gcccagcaag ccaggccctt catgaaggcc     1620

aagaaggctg ccaccattcc ctgccagccc aagaactcca gcttccccac tgcctctgtg     1680

tgcccctttg cgtcctgtga aggccattga gaaatgccca gtgtgccccc tgggaaaggg     1740

cacggcctgt gctcctgaca cgggctgtgc ttggccacag aaccacccag cgtctcccct     1800

gctgctgtcc acgtcagttc atgaggcaac gtcgcgtggt ctcagacgtg gagcagccag     1860

cggcagctca gagcagggca ctgtgtccgg cggagccaag tccactctgg gggagctctg     1920

gcggggacca cgggccactg ctcacccact ggccccgagg ggggtgtaga cgccaagact     1980

cacgcatgtg tgacatccgg agtcctggag ccgggtgtcc cagtggcacc actaggtgcc     2040

tgctgcctcc acagtggggt tcacacccag ggctccttgg tcccccacaa cctgccccgg     2100

ccaggcctgc agacccagac tccagccaga cctgcctcac ccaccaatgc agccggggct     2160

ggcgacacca gccaggtgct ggtcttgggc cagttctccc acgacggctc accctcccct     2220

ccatctgcgt tgatgctcag aatcgcctac ctgtgcctgc gtgtaaacca cagcctcaga     2280

ccagctatgg ggagaggaca acacggagga tatccagctt ccccggtctg gggtgaggaa     2340

tgtggggagc ttgggcatcc tcctccagcc tcctccagcc cccaggcagt gccttacctg     2400

tggtgcccag aaaagtgccc ctaggttggt gggtctacag gagcctcagc caggcagccc     2460

accccaccct ggggccctgc ctcaccaagg aaataaagac tcaagccatt taaaaaaaaa     2520

aaaaa                                                                 2525


<210> 11
<211> 263
<212> PRT
<213> Homo sapiens

<400> 11
Met Arg Pro Gly Ala Pro Gly Pro Leu Trp Pro Leu Pro Trp Gly Ala 
1               5                   10                  15      


Leu Ala Trp Ala Val Gly Phe Val Ser Ser Met Gly Ser Gly Asn Pro 
            20                  25                  30          


Ala Pro Gly Gly Val Cys Trp Leu Gln Gln Gly Gln Glu Ala Thr Cys 
        35                  40                  45              


Ser Leu Val Leu Gln Thr Asp Val Thr Arg Ala Glu Cys Cys Ala Ser 
    50                  55                  60                  


Gly Asn Ile Asp Thr Ala Trp Ser Asn Leu Thr His Pro Gly Asn Lys 
65                  70                  75                  80  


Ile Asn Leu Leu Gly Phe Leu Gly Leu Val His Cys Leu Pro Cys Lys 
                85                  90                  95      


Asp Ser Cys Asp Gly Val Glu Cys Gly Pro Gly Lys Ala Cys Arg Met 
            100                 105                 110         


Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly Leu 
        115                 120                 125             


Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg Asp 
    130                 135                 140                 


Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu Ser 
145                 150                 155                 160 


Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val Cys 
                165                 170                 175     


Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His Cys 
            180                 185                 190         


Val Val Cys Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln 
        195                 200                 205             


Glu Leu Cys Gly Asn Asn Asn Val Thr Tyr Ile Ser Ser Cys His Met 
    210                 215                 220                 


Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His Ala 
225                 230                 235                 240 


Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser Ala 
                245                 250                 255     


Glu Glu Glu Glu Asn Phe Val 
            260             


<210> 12
<211> 337
<212> PRT
<213> Homo sapiens

<400> 12
Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr Lys Ser Ser Arg Ile Glu 
1               5                   10                  15      


Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro 
            20                  25                  30          


Asn Ile Ser Lys Asp Val Ile Arg Gln Leu Leu Pro Lys Ala Pro Pro 
        35                  40                  45              


Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser 
    50                  55                  60                  


Asp Gly Ser Leu Glu Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile 
65                  70                  75                  80  


Ile Thr Met Pro Thr Glu Ser Asp Phe Leu Met Gln Val Asp Gly Lys 
                85                  90                  95      


Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys 
            100                 105                 110         


Val Val Lys Ala Gln Leu Trp Ile Tyr Leu Arg Pro Val Glu Thr Pro 
        115                 120                 125             


Thr Thr Val Phe Val Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp 
    130                 135                 140                 


Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu Lys Leu Asp Met Asn Pro 
145                 150                 155                 160 


Gly Thr Gly Ile Trp Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn 
                165                 170                 175     


Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu 
            180                 185                 190         


Asp Glu Asn Gly His Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu 
        195                 200                 205             


Asp Gly Leu Asn Pro Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys 
    210                 215                 220                 


Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu 
225                 230                 235                 240 


Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly 
                245                 250                 255     


Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser 
            260                 265                 270         


Gly Glu Cys Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu 
        275                 280                 285             


Val His Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro 
    290                 295                 300                 


Thr Lys Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln 
305                 310                 315                 320 


Ile Ile Tyr Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys 
                325                 330                 335     


Ser 
    


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
tggaacaacc cggtaaagag t                                                 21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
caccaggggc ataatgagca g                                                 21


<210> 15
<211> 15
<212> PRT
<213> Homo sapiens

<400> 15
Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys 
1               5                   10                  15  


<210> 16
<211> 15
<212> PRT
<213> Homo sapiens

<400> 16
Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys Tyr Pro His Thr 
1               5                   10                  15  


<210> 17
<211> 361
<212> PRT
<213> Mus musculus

<400> 17
Arg Ser Ser Arg Pro Ala Pro Ser Ala Pro Pro Glu Pro Asp Gly Cys 
1               5                   10                  15      


Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser 
            20                  25                  30          


Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn 
        35                  40                  45              


Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu 
    50                  55                  60                  


Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val 
                85                  90                  95      


Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser 
            100                 105                 110         


Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys 
        115                 120                 125             


Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro 
    130                 135                 140                 


Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu 
145                 150                 155                 160 


Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg 
                165                 170                 175     


Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile 
            180                 185                 190         


Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn 
        195                 200                 205             


Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala 
    210                 215                 220                 


Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu 
225                 230                 235                 240 


Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu 
                245                 250                 255     


Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu 
            260                 265                 270         


Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys 
        275                 280                 285             


Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met 
    290                 295                 300                 


Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly 
305                 310                 315                 320 


Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met 
                325                 330                 335     


Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly 
            340                 345                 350         


Met Val Val Asp Arg Cys Gly Cys Ser 
        355                 360     


