                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       UNIVERSITE PARIS DIDEROT-PARIS 7
 
<120>  A subunit vaccine platform based on multimeric ribonucleoproteins
        comprising nucleoproteins of a non-segmented negative-strand RNA
        virus as carriers of heterologous polypeptides

<130>  B10277A AD/DP/AM

<140>  PCT/EP XXXXXXX
<141>  2014-09-17

<150>  EP 13306577.1
<151>  2013-11-18

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Schwarz/Moraten MV

<400>  1
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtgag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgggaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagac                                                      1575


<210>  2
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Schwarz/Moraten MV

<400>  2
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cggaaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagat                                                      1575


<210>  3
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the nucleoprotein of Schwarz/Moraten MV

<400>  3

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp 
        515                 520                 525 


<210>  4
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Rubeovax MV

<400>  4
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtcag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgagaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtggttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagac                                                      1575


<210>  5
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Rubeovax MV

<400>  5
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cgagaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagat                                                      1575


<210>  6
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the nucleoprotein of Rubeovax MV

<400>  6

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Glu Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp 
        515                 520                 525 


<210>  7
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of AIK-C MV

<400>  7
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtcag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggacaaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgagaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcatcggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagac                                                      1575


<210>  8
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of AIK-C MV

<400>  8
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgataagtat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cgagaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcatctgaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagat                                                      1575


<210>  9
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the nucleoprotein of AIK-C MV

<400>  9

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Lys Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Glu Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Ser Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp 
        515                 520                 525 


<210>  10
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Zagreb MV

<400>  10
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtcag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgagaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagctcaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcatcggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagac                                                      1575


<210>  11
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Zagreb MV or of the nucleoprotein of Edmonston 
       MV

<400>  11
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cgagaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcatctgaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagat                                                      1575


<210>  12
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the nucleoprotein of Zagreb MV or of the 
       nucleoprotein of Edmonston MV

<400>  12

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Glu Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Ser Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp 
        515                 520                 525 


<210>  13
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       nucleoprotein of Edmonston MV

<400>  13
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtcag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgagaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcatcggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagac                                                      1575


<210>  14
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the CS 
       polypeptide of P. berghei

<400>  14
agcatccaag cccaaaggaa cttaaacgag ctatgttaca atgaaggaaa tgataataaa       60

ttgtatcacg tgcttaactc taagaatgga aaaatataca atcgaaatac agtcaacaga      120

ttacttgccg atgctcccga aggaaaaaaa aatgagaaaa aaaacgaaaa aatagagcgt      180

aataataaat tgaaacaacc accaccacca ccaaacccaa atgacccacc accaccaaac      240

ccaaatgacc caccaccacc aaacccaaat gacccaccac caccaaaccc aaatgaccca      300

ccaccaccaa acgcaaatga cccaccacca ccaaacgcaa atgacccagc accaccaaac      360

gcaaatgacc cagcaccacc aaacgcaaat gacccagcac caccaaacgc aaatgaccca      420

gcaccaccaa acgcaaatga cccaccacca ccaaacccaa atgacccagc accaccaaac      480

gcaaatgacc caccaccacc aaacccaaat gacccagcac caccacaagg aaataacaat      540

ccacaaccac agccacggcc gcagccacaa ccacagccac agccacaacc acagccacag      600

ccacaaccac agccacgacc acagccacaa ccacagccag gtggtaataa caataacaaa      660

aataataata atgacgattc ttatatccca agcgcggaaa aaatactaga atttgttaaa      720

cagatcaggg atagtatcac agaggaatgg tctcaatgta acgtaacatg tggttctggt      780

ataagagtta gaaaacgaaa aggttcaaat aagaaagcag aagatttgac cttagaagat      840

attgatactg aaatttgtaa aatggataaa tgttcaagta tatttaatat tgtaagcaat      900

tcatagtag                                                              909


<210>  15
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       CS polypeptide of P. berghei

<400>  15
tccatccagg cccagagaaa cttgaacgaa ctttgctaca acgaaggaaa cgacaacaaa       60

ctttaccacg tcttgaactc taagaatggt aaaatctaca acagaaacac agttaacaga      120

ttgcttgctg atgccccaga aggaaagaaa aatgagaaga aaaacgaaaa gatcgagaga      180

aacaataagt tgaaacaacc tcctccacct ccaaatccaa acgatcctcc acctccaaat      240

cctaacgacc cacctccacc taaccctaat gacccacctc cacctaatcc taacgaccct      300

ccacctccaa atgctaatga cccacctcct ccaaatgcaa acgacccagc tcctccaaat      360

gccaacgatc ctgcacctcc aaatgctaac gacccagccc ctccaaatgc aaacgatcct      420

gcccctccaa atgccaatga tccacctcca cctaatccaa atgacccagc accaccaaat      480

gccaatgatc ctcctccacc taacccaaac gatcctgctc ctccacaggg taacaataac      540

cctcaaccac agcctagacc acaacctcag cctcagcctc agccacaacc acaaccacaa      600

cctcagccac aacctagacc acagcctcaa ccacagcctg gtggaaataa taataacaaa      660

aacaacaaca acgatgactc ttatattcca tccgccgaaa agatccttga gtttgtcaag      720

caaatcagag actcaatcac cgaagagtgg agtcaatgta atgttacttg cggttctgga      780

attagagtca gaaagagaaa aggttctaac aagaaagctg aagatttgac tcttgaggat      840

atcgacacag agatttgtaa gatggataag tgctcaagta ttttcaacat tgtcagtaac      900

tcatagtag                                                              909


<210>  16
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the CS polypeptide of P. berghei

<400>  16

Ser Ile Gln Ala Gln Arg Asn Leu Asn Glu Leu Cys Tyr Asn Glu Gly 
1               5                   10                  15      


Asn Asp Asn Lys Leu Tyr His Val Leu Asn Ser Lys Asn Gly Lys Ile 
            20                  25                  30          


Tyr Asn Arg Asn Thr Val Asn Arg Leu Leu Ala Asp Ala Pro Glu Gly 
        35                  40                  45              


Lys Lys Asn Glu Lys Lys Asn Glu Lys Ile Glu Arg Asn Asn Lys Leu 
    50                  55                  60                  


Lys Gln Pro Pro Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn 
65                  70                  75                  80  


Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn 
                85                  90                  95      


Pro Asn Asp Pro Pro Pro Pro Asn Ala Asn Asp Pro Pro Pro Pro Asn 
            100                 105                 110         


Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn 
        115                 120                 125             


Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn 
    130                 135                 140                 


Ala Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Ala Pro Pro Asn 
145                 150                 155                 160 


Ala Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro Ala Pro Pro Gln 
                165                 170                 175     


Gly Asn Asn Asn Pro Gln Pro Gln Pro Arg Pro Gln Pro Gln Pro Gln 
            180                 185                 190         


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Arg Pro Gln 
        195                 200                 205             


Pro Gln Pro Gln Pro Gly Gly Asn Asn Asn Asn Lys Asn Asn Asn Asn 
    210                 215                 220                 


Asp Asp Ser Tyr Ile Pro Ser Ala Glu Lys Ile Leu Glu Phe Val Lys 
225                 230                 235                 240 


Gln Ile Arg Asp Ser Ile Thr Glu Glu Trp Ser Gln Cys Asn Val Thr 
                245                 250                 255     


Cys Gly Ser Gly Ile Arg Val Arg Lys Arg Lys Gly Ser Asn Lys Lys 
            260                 265                 270         


Ala Glu Asp Leu Thr Leu Glu Asp Ile Asp Thr Glu Ile Cys Lys Met 
        275                 280                 285             


Asp Lys Cys Ser Ser Ile Phe Asn Ile Val Ser Asn Ser 
    290                 295                 300     


<210>  17
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the CS 
       polypeptide of P. falciparum

<400>  17
ggatccagca gcaacacgcg tgttctgaac gaactgaact acgataacgc tggtaccaat       60

ctgtacaacg aactggaaat gaactactac ggtaaacagg aaaactggta cagcctgaaa      120

aaaaacagca gatctctagg cgaaaacgac gacggcaaca acaacaacgg tgataacggt      180

cgcgaaggta aagacgaaga caaacgcgac ggcaacaacg aagacaacga aaaacttcgc      240

aaaccgaaac acaaaaaact taagcagcca ggggatggta atccagatcc gaacgcgaat      300

ccgaacgtag acccgaacgc aaacccgaac gtagacccga acgcaaaccc gaacgtagac      360

ccgaacgcga atccgaacgc gaaccctaac gcgaacccga acgcgaaccc gaacgcgaac      420

ccgaacgcga acccgaacgc gaacccgaac gcgaacccga acgcgaaccc gaacgcgaac      480

ccgaacgcga acccgaacgc gaacccgaac gcgaacccga acgcgaaccc gaacgcgaac      540

ccgaacgcga acccgaacgc gaacccgaac gcgaacccga acgcgaaccc gaacgcgaac      600

ccgaacgcga acccgaacaa aaacaatcag ggtaatggcc agggtcacaa tatgccaaat      660

gacccaaacc gaaatgtaga tgaaaatgct aatgccaaca atgctgtaaa aaataataat      720

aacgaagaac caagtgataa gcacatagaa caatatttaa agaaaataca aaattctctt      780

tcaactgaat ggtccccatg tagtgtaact tgcggcaacg gtattcaggt gcgcatcaag      840

ccgggctctg ctaacaaacc taaggacgaa ctggattacg aaaacgatat cgaaaaaaag      900

atctgtaaga tggaaaagtg ttcctctgta ttcaacgtag ttaactcttc g               951


<210>  18
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       CS polypeptide of P. falciparum

<400>  18
ggcagttctt ctaacactcg tgttctaaat gagttgaatt atgacaacgc aggaactaat       60

ttgtacaatg agctggagat gaattactac ggtaagcagg agaactggta ttctttgaaa      120

aagaatagta gatctctggg agaaaatgac gacgggaata ataacaatgg agataatggt      180

agagaaggta aagatgaaga taagagggat ggtaacaacg aagacaatga aaagcttcgt      240

aagccaaaac acaaaaagct taagcaacca ggtgatggta acccagatcc taatgctaac      300

ccaaacgtag accctaacgc aaatcccaac gtggatccaa atgccaatcc taacgtagat      360

cccaacgcaa accctaacgc aaatcctaat gctaatccca atgctaatcc aaacgcaaac      420

cctaatgcaa accccaatgc taacccaaat gctaacccaa acgccaaccc taatgctaac      480

cctaacgcca accctaacgc taatcctaac gcaaacccaa atgccaatcc aaacgccaat      540

cctaacgcta accctaatgc caaccctaac gccaatccaa acgctaatcc aaacgctaac      600

ccaaatgcaa atcctaacaa gaacaaccaa ggtaatggtc agggccataa catgccaaat      660

gatcctaatc gtaatgtcga tgaaaacgca aatgcaaata atgccgttaa aaacaacaac      720

aacgaagaac cttcagataa acacattgaa cagtacctta agaaaattca aaattccttg      780

tctacggaat ggtccccatg ctctgtcact tgtggtaatg gcatacaagt gagaattaag      840

cctggttctg caaacaaacc aaaagacgaa cttgattatg aaaacgatat cgaaaagaag      900

atttgcaaaa tggagaaatg ttcttcagta ttcaacgtgg ttaatagttc ctaatag         957


<210>  19
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the CS polypeptide of P. falciparum

<400>  19

Gly Ser Ser Ser Asn Thr Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn 
1               5                   10                  15      


Ala Gly Thr Asn Leu Tyr Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys 
            20                  25                  30          


Gln Glu Asn Trp Tyr Ser Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu 
        35                  40                  45              


Asn Asp Asp Gly Asn Asn Asn Asn Gly Asp Asn Gly Arg Glu Gly Lys 
    50                  55                  60                  


Asp Glu Asp Lys Arg Asp Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg 
65                  70                  75                  80  


Lys Pro Lys His Lys Lys Leu Lys Gln Pro Gly Asp Gly Asn Pro Asp 
                85                  90                  95      


Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp 
            100                 105                 110         


Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn 
        115                 120                 125             


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
    130                 135                 140                 


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
145                 150                 155                 160 


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
                165                 170                 175     


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
            180                 185                 190         


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys Asn 
        195                 200                 205             


Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn Arg 
    210                 215                 220                 


Asn Val Asp Glu Asn Ala Asn Ala Asn Asn Ala Val Lys Asn Asn Asn 
225                 230                 235                 240 


Asn Glu Glu Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile 
                245                 250                 255     


Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly 
            260                 265                 270         


Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys 
        275                 280                 285             


Asp Glu Leu Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met 
    290                 295                 300                 


Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser 
305                 310                 315         


<210>  20
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the VP1
       protein from Enterovirus 71

<400>  20
ggagataggg tggcagatgt aattgaaagc tccataggag atagcgtgag cagagccctc       60

actcacgctc taccagcacc cacaggtcag aacacacagg tgagcagtca tcgactggat      120

acgggcaagg ttccagcact ccaagctgct gaaattggag catcatcaaa tgctagtgac      180

gagagtatga ttgagacacg ctgtgtcctc aactcgcaca gtacagcaga gaccactctt      240

gatagtttct tcagcagggc gggattagtt ggagagatag atctccctct tgagggcaca      300

actaacccaa atggttatgc caactgggac atagatataa caggttacgc gcaaatgcgt      360

agaaaggtag agctcttcac ctacatgcgc tttgatgcag agttcacttt tgttgcgtgt      420

acacctaccg gggaagttgt tccacaactg ctccaatata tgtttgtgcc acctggagcc      480

ccaaagccag attctaggga atcccttgca tggcaaaccg ccactaaccc ctcagttttt      540

gtcaagctgt cagaccctcc agcacaggtt tcagtgccat tcatgtcacc tgcgagtgct      600

tatcaatggt tttatgacgg atatcccacg ttcggagaac acaaacagga gaaagatctt      660

gaatatgggg catgtcctaa taacatgatg ggcacgttct cagtgcggac tgtagggtcc      720

tccaagtcca agtaccctct agtgattagg atttacatga gaatgaagca cgtcagggcg      780

tggatacctc gcccgatgcg taaccagaac tacctattca aagccaatcc aaattatgct      840

ggcaactccg ttaagccaac tggtgccagt cgcacagcga tcaccactct ttgatga         897


<210>  21
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       VP1 protein from Enterovirus 71

<400>  21
ggagatagag tcgccgatgt tattgagtct tccattggag attcagttag tagagccttg       60

acacacgcct tgccagcccc aaccggacaa aacactcagg tttcttccca tagattggat      120

acaggaaagg tccctgctct tcaagctgcc gagattggtg cctcaagtaa cgcatctgac      180

gaatccatga tcgagactag atgtgttttg aattcacaca gtacagctga aactacattg      240

gattcatttt tcagtagagc cggtcttgtt ggagagattg acttgccact tgaaggtacc      300

actaacccta atggatacgc caactgggat attgacatca ctggttatgc acagatgaga      360

agaaaagttg agttgtttac ctacatgaga ttcgatgcag aattcacttt cgttgcttgc      420

acaccaaccg gagaggttgt ccctcaattg cttcagtata tgtttgttcc acctggtgct      480

ccaaagcctg attctagaga atccttggct tggcaaactg ccacaaatcc atccgttttt      540

gtcaaacttt cagacccacc tgctcaagtt tctgtcccat tcatgtcacc tgcaagtgct      600

taccagtggt tttacgatgg ttatccaact ttcggagaac ataagcagga gaaagacttg      660

gaatatggtg cttgtcctaa caatatgatg ggaacatttt ctgttagaac cgtcggttct      720

tccaagtcca agtacccatt ggttattaga atctatatga gaatgaagca cgtcagagca      780

tggatcccaa gacctatgag aaaccaaaat taccttttca aagctaaccc taattatgca      840

ggaaactcag tcaagcctac aggagcatca agaaccgcca tcacaacact ttagtaa         897


<210>  22
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VP1 protein from Enterovirus 71

<400>  22

Gly Asp Arg Val Ala Asp Val Ile Glu Ser Ser Ile Gly Asp Ser Val 
1               5                   10                  15      


Ser Arg Ala Leu Thr His Ala Leu Pro Ala Pro Thr Gly Gln Asn Thr 
            20                  25                  30          


Gln Val Ser Ser His Arg Leu Asp Thr Gly Lys Val Pro Ala Leu Gln 
        35                  40                  45              


Ala Ala Glu Ile Gly Ala Ser Ser Asn Ala Ser Asp Glu Ser Met Ile 
    50                  55                  60                  


Glu Thr Arg Cys Val Leu Asn Ser His Ser Thr Ala Glu Thr Thr Leu 
65                  70                  75                  80  


Asp Ser Phe Phe Ser Arg Ala Gly Leu Val Gly Glu Ile Asp Leu Pro 
                85                  90                  95      


Leu Glu Gly Thr Thr Asn Pro Asn Gly Tyr Ala Asn Trp Asp Ile Asp 
            100                 105                 110         


Ile Thr Gly Tyr Ala Gln Met Arg Arg Lys Val Glu Leu Phe Thr Tyr 
        115                 120                 125             


Met Arg Phe Asp Ala Glu Phe Thr Phe Val Ala Cys Thr Pro Thr Gly 
    130                 135                 140                 


Glu Val Val Pro Gln Leu Leu Gln Tyr Met Phe Val Pro Pro Gly Ala 
145                 150                 155                 160 


Pro Lys Pro Asp Ser Arg Glu Ser Leu Ala Trp Gln Thr Ala Thr Asn 
                165                 170                 175     


Pro Ser Val Phe Val Lys Leu Ser Asp Pro Pro Ala Gln Val Ser Val 
            180                 185                 190         


Pro Phe Met Ser Pro Ala Ser Ala Tyr Gln Trp Phe Tyr Asp Gly Tyr 
        195                 200                 205             


Pro Thr Phe Gly Glu His Lys Gln Glu Lys Asp Leu Glu Tyr Gly Ala 
    210                 215                 220                 


Cys Pro Asn Asn Met Met Gly Thr Phe Ser Val Arg Thr Val Gly Ser 
225                 230                 235                 240 


Ser Lys Ser Lys Tyr Pro Leu Val Ile Arg Ile Tyr Met Arg Met Lys 
                245                 250                 255     


His Val Arg Ala Trp Ile Pro Arg Pro Met Arg Asn Gln Asn Tyr Leu 
            260                 265                 270         


Phe Lys Ala Asn Pro Asn Tyr Ala Gly Asn Ser Val Lys Pro Thr Gly 
        275                 280                 285             


Ala Ser Arg Thr Ala Ile Thr Thr Leu 
    290                 295         


<210>  23
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       avidin protein

<400>  23
gccagaaagt gctcgctgac tgggaaatgg accaacgatc tgggctccaa catgaccatc       60

ggggctgtga acagcagagg tgaattcaca ggcacctaca tcacagccgt aacagccaca      120

tcaaatgaga tcaaagagtc accactgcat gggacacaaa acaccatcaa caagaggacc      180

cagcccacct ttggcttcac cgtcaattgg aagttttcag agtccaccac tgtcttcacg      240

ggccagtgct tcatagacag gaatgggaag gaggtcctga agaccatgtg gctgctgcgg      300

tcaagtgtta atgacattgg tgatgactgg aaagctacca gggtcggcat caacatcttc      360

actcgcctgc gcacacagaa ggagtagtag                                       390


<210>  24
<211>  389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       avidin protein

<400>  24
ctagaaaatg ttcacttact ggaaaatgga caaatgacct tggttcaaat atgacaatcg       60

gtgctgttaa tagtcgtggt gaattcactg gaacttacat tactgctgtt acagccacct      120

ctaacgaaat caaggagtcc ccattgcatg gtactcaaaa cactattaac aagagaaccc      180

agcctacttt tggattcaca gttaattgga agttctcaga aagtactaca gtctttactg      240

gtcaatgttt cattgataga aacggaaagg aggttcttaa aactatgtgg ttgcttagat      300

cttccgtcaa tgacatcgga gatgactgga aggcaaccag agtcggtatt aacattttca      360

caagattgag aacccagaag gagtagtaa                                        389


<210>  25
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the avidin protein

<400>  25

Ala Arg Lys Cys Ser Leu Thr Gly Lys Trp Thr Asn Asp Leu Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Gly Ala Val Asn Ser Arg Gly Glu Phe Thr Gly Thr 
            20                  25                  30          


Tyr Ile Thr Ala Val Thr Ala Thr Ser Asn Glu Ile Lys Glu Ser Pro 
        35                  40                  45              


Leu His Gly Thr Gln Asn Thr Ile Asn Lys Arg Thr Gln Pro Thr Phe 
    50                  55                  60                  


Gly Phe Thr Val Asn Trp Lys Phe Ser Glu Ser Thr Thr Val Phe Thr 
65                  70                  75                  80  


Gly Gln Cys Phe Ile Asp Arg Asn Gly Lys Glu Val Leu Lys Thr Met 
                85                  90                  95      


Trp Leu Leu Arg Ser Ser Val Asn Asp Ile Gly Asp Asp Trp Lys Ala 
            100                 105                 110         


Thr Arg Val Gly Ile Asn Ile Phe Thr Arg Leu Arg Thr Gln Lys Glu 
        115                 120                 125             


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the peptide linker used in the N-PbCS, 
       N-VP1 and N-Avidin fusion proteins

<400>  26
ggcgccgcgg gagcaggtgc a                                                 21


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide linker used in the N-PbCS, 
       N-VP1 and N-Avidin fusion proteins

<400>  27

Gly Ala Ala Gly Ala Gly Ala 
1               5           


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the peptide linker used in the N-PfCS 
       fusion protein

<400>  28
ggcgcaggag caggagct                                                     18


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide linker used in the N-PfCS 
       fusion protein

<400>  29

Gly Ala Gly Ala Gly Ala 
1               5       


<210>  30
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       N-PbCS fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  30
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtgag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgggaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagacggcgc cgcgggagca ggtgcaagca tccaagccca aaggaactta     1620

aacgagctat gttacaatga aggaaatgat aataaattgt atcacgtgct taactctaag     1680

aatggaaaaa tatacaatcg aaatacagtc aacagattac ttgccgatgc tcccgaagga     1740

aaaaaaaatg agaaaaaaaa cgaaaaaata gagcgtaata ataaattgaa acaaccacca     1800

ccaccaccaa acccaaatga cccaccacca ccaaacccaa atgacccacc accaccaaac     1860

ccaaatgacc caccaccacc aaacccaaat gacccaccac caccaaacgc aaatgaccca     1920

ccaccaccaa acgcaaatga cccagcacca ccaaacgcaa atgacccagc accaccaaac     1980

gcaaatgacc cagcaccacc aaacgcaaat gacccagcac caccaaacgc aaatgaccca     2040

ccaccaccaa acccaaatga cccagcacca ccaaacgcaa atgacccacc accaccaaac     2100

ccaaatgacc cagcaccacc acaaggaaat aacaatccac aaccacagcc acggccgcag     2160

ccacaaccac agccacagcc acaaccacag ccacagccac aaccacagcc acgaccacag     2220

ccacaaccac agccaggtgg taataacaat aacaaaaata ataataatga cgattcttat     2280

atcccaagcg cggaaaaaat actagaattt gttaaacaga tcagggatag tatcacagag     2340

gaatggtctc aatgtaacgt aacatgtggt tctggtataa gagttagaaa acgaaaaggt     2400

tcaaataaga aagcagaaga tttgacctta gaagatattg atactgaaat ttgtaaaatg     2460

gataaatgtt caagtatatt taatattgta agcaattcat agtag                     2505


<210>  31
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       N-PbCS fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain)including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  31
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cggaaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagatggcgc cgcgggagca ggtgcatcca tccaggccca gagaaacttg     1620

aacgaacttt gctacaacga aggaaacgac aacaaacttt accacgtctt gaactctaag     1680

aatggtaaaa tctacaacag aaacacagtt aacagattgc ttgctgatgc cccagaagga     1740

aagaaaaatg agaagaaaaa cgaaaagatc gagagaaaca ataagttgaa acaacctcct     1800

ccacctccaa atccaaacga tcctccacct ccaaatccta acgacccacc tccacctaac     1860

cctaatgacc cacctccacc taatcctaac gaccctccac ctccaaatgc taatgaccca     1920

cctcctccaa atgcaaacga cccagctcct ccaaatgcca acgatcctgc acctccaaat     1980

gctaacgacc cagcccctcc aaatgcaaac gatcctgccc ctccaaatgc caatgatcca     2040

cctccaccta atccaaatga cccagcacca ccaaatgcca atgatcctcc tccacctaac     2100

ccaaacgatc ctgctcctcc acagggtaac aataaccctc aaccacagcc tagaccacaa     2160

cctcagcctc agcctcagcc acaaccacaa ccacaacctc agccacaacc tagaccacag     2220

cctcaaccac agcctggtgg aaataataat aacaaaaaca acaacaacga tgactcttat     2280

attccatccg ccgaaaagat ccttgagttt gtcaagcaaa tcagagactc aatcaccgaa     2340

gagtggagtc aatgtaatgt tacttgcggt tctggaatta gagtcagaaa gagaaaaggt     2400

tctaacaaga aagctgaaga tttgactctt gaggatatcg acacagagat ttgtaagatg     2460

gataagtgct caagtatttt caacattgtc agtaactcat agtag                     2505


<210>  32
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the polynucleotide encoding the N-PbCS 
       fusion protein (the nucleoprotein N is obtained from the Schwarz 
       strain) including the amino acid sequence of the peptide linker 
       disclosed as sequence SEQ ID No: 27

<400>  32

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp Gly Ala Ala 
        515                 520                 525             


Gly Ala Gly Ala Ser Ile Gln Ala Gln Arg Asn Leu Asn Glu Leu Cys 
    530                 535                 540                 


Tyr Asn Glu Gly Asn Asp Asn Lys Leu Tyr His Val Leu Asn Ser Lys 
545                 550                 555                 560 


Asn Gly Lys Ile Tyr Asn Arg Asn Thr Val Asn Arg Leu Leu Ala Asp 
                565                 570                 575     


Ala Pro Glu Gly Lys Lys Asn Glu Lys Lys Asn Glu Lys Ile Glu Arg 
            580                 585                 590         


Asn Asn Lys Leu Lys Gln Pro Pro Pro Pro Pro Asn Pro Asn Asp Pro 
        595                 600                 605             


Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro 
    610                 615                 620                 


Pro Pro Pro Asn Pro Asn Asp Pro Pro Pro Pro Asn Ala Asn Asp Pro 
625                 630                 635                 640 


Pro Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro 
                645                 650                 655     


Ala Pro Pro Asn Ala Asn Asp Pro Ala Pro Pro Asn Ala Asn Asp Pro 
            660                 665                 670         


Ala Pro Pro Asn Ala Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro 
        675                 680                 685             


Ala Pro Pro Asn Ala Asn Asp Pro Pro Pro Pro Asn Pro Asn Asp Pro 
    690                 695                 700                 


Ala Pro Pro Gln Gly Asn Asn Asn Pro Gln Pro Gln Pro Arg Pro Gln 
705                 710                 715                 720 


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln 
                725                 730                 735     


Pro Arg Pro Gln Pro Gln Pro Gln Pro Gly Gly Asn Asn Asn Asn Lys 
            740                 745                 750         


Asn Asn Asn Asn Asp Asp Ser Tyr Ile Pro Ser Ala Glu Lys Ile Leu 
        755                 760                 765             


Glu Phe Val Lys Gln Ile Arg Asp Ser Ile Thr Glu Glu Trp Ser Gln 
    770                 775                 780                 


Cys Asn Val Thr Cys Gly Ser Gly Ile Arg Val Arg Lys Arg Lys Gly 
785                 790                 795                 800 


Ser Asn Lys Lys Ala Glu Asp Leu Thr Leu Glu Asp Ile Asp Thr Glu 
                805                 810                 815     


Ile Cys Lys Met Asp Lys Cys Ser Ser Ile Phe Asn Ile Val Ser Asn 
            820                 825                 830         


Ser 
    


<210>  33
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       N-PfCS fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 28

<400>  33
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtgag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgggaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagacggcgc aggagcagga gctggatcca gcagcaacac gcgtgttctg     1620

aacgaactga actacgataa cgctggtacc aatctgtaca acgaactgga aatgaactac     1680

tacggtaaac aggaaaactg gtacagcctg aaaaaaaaca gcagatctct aggcgaaaac     1740

gacgacggca acaacaacaa cggtgataac ggtcgcgaag gtaaagacga agacaaacgc     1800

gacggcaaca acgaagacaa cgaaaaactt cgcaaaccga aacacaaaaa acttaagcag     1860

ccaggggatg gtaatccaga tccgaacgcg aatccgaacg tagacccgaa cgcaaacccg     1920

aacgtagacc cgaacgcaaa cccgaacgta gacccgaacg cgaatccgaa cgcgaaccct     1980

aacgcgaacc cgaacgcgaa cccgaacgcg aacccgaacg cgaacccgaa cgcgaacccg     2040

aacgcgaacc cgaacgcgaa cccgaacgcg aacccgaacg cgaacccgaa cgcgaacccg     2100

aacgcgaacc cgaacgcgaa cccgaacgcg aacccgaacg cgaacccgaa cgcgaacccg     2160

aacgcgaacc cgaacgcgaa cccgaacgcg aacccgaacg cgaacccgaa caaaaacaat     2220

cagggtaatg gccagggtca caatatgcca aatgacccaa accgaaatgt agatgaaaat     2280

gctaatgcca acaatgctgt aaaaaataat aataacgaag aaccaagtga taagcacata     2340

gaacaatatt taaagaaaat acaaaattct ctttcaactg aatggtcccc atgtagtgta     2400

acttgcggca acggtattca ggtgcgcatc aagccgggct ctgctaacaa acctaaggac     2460

gaactggatt acgaaaacga tatcgaaaaa aagatctgta agatggaaaa gtgttcctct     2520

gtattcaacg tagttaactc ttcg                                            2544


<210>  34
<211>  2550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       N-PfCS fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 28

<400>  34
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cggaaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagatggcgc aggagcagga gctggcagtt cttctaacac tcgtgttcta     1620

aatgagttga attatgacaa cgcaggaact aatttgtaca atgagctgga gatgaattac     1680

tacggtaagc aggagaactg gtattctttg aaaaagaata gtagatctct gggagaaaat     1740

gacgacggga ataataacaa tggagataat ggtagagaag gtaaagatga agataagagg     1800

gatggtaaca acgaagacaa tgaaaagctt cgtaagccaa aacacaaaaa gcttaagcaa     1860

ccaggtgatg gtaacccaga tcctaatgct aacccaaacg tagaccctaa cgcaaatccc     1920

aacgtggatc caaatgccaa tcctaacgta gatcccaacg caaaccctaa cgcaaatcct     1980

aatgctaatc ccaatgctaa tccaaacgca aaccctaatg caaaccccaa tgctaaccca     2040

aatgctaacc caaacgccaa ccctaatgct aaccctaacg ccaaccctaa cgctaatcct     2100

aacgcaaacc caaatgccaa tccaaacgcc aatcctaacg ctaaccctaa tgccaaccct     2160

aacgccaatc caaacgctaa tccaaacgct aacccaaatg caaatcctaa caagaacaac     2220

caaggtaatg gtcagggcca taacatgcca aatgatccta atcgtaatgt cgatgaaaac     2280

gcaaatgcaa ataatgccgt taaaaacaac aacaacgaag aaccttcaga taaacacatt     2340

gaacagtacc ttaagaaaat tcaaaattcc ttgtctacgg aatggtcccc atgctctgtc     2400

acttgtggta atggcataca agtgagaatt aagcctggtt ctgcaaacaa accaaaagac     2460

gaacttgatt atgaaaacga tatcgaaaag aagatttgca aaatggagaa atgttcttca     2520

gtattcaacg tggttaatag ttcctaatag                                      2550


<210>  35
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the polynucleotide encoding the N-PfCS 
       fusion protein (the nucleoprotein N is obtained from the Schwarz 
       strain) including the amino acid sequence of the peptide linker 
       disclosed as sequence SEQ ID No: 29

<400>  35

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp Gly Ala Gly 
        515                 520                 525             


Ala Gly Ala Gly Ser Ser Ser Asn Thr Arg Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Tyr Asp Asn Ala Gly Thr Asn Leu Tyr Asn Glu Leu Glu Met Asn Tyr 
545                 550                 555                 560 


Tyr Gly Lys Gln Glu Asn Trp Tyr Ser Leu Lys Lys Asn Ser Arg Ser 
                565                 570                 575     


Leu Gly Glu Asn Asp Asp Gly Asn Asn Asn Asn Gly Asp Asn Gly Arg 
            580                 585                 590         


Glu Gly Lys Asp Glu Asp Lys Arg Asp Gly Asn Asn Glu Asp Asn Glu 
        595                 600                 605             


Lys Leu Arg Lys Pro Lys His Lys Lys Leu Lys Gln Pro Gly Asp Gly 
    610                 615                 620                 


Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro 
625                 630                 635                 640 


Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro 
                645                 650                 655     


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            660                 665                 670         


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        675                 680                 685             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    690                 695                 700                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
705                 710                 715                 720 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                725                 730                 735     


Asn Lys Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp 
            740                 745                 750         


Pro Asn Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Asn Ala Val Lys 
        755                 760                 765             


Asn Asn Asn Asn Glu Glu Pro Ser Asp Lys His Ile Glu Gln Tyr Leu 
    770                 775                 780                 


Lys Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val 
785                 790                 795                 800 


Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn 
                805                 810                 815     


Lys Pro Lys Asp Glu Leu Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile 
            820                 825                 830         


Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser 
        835                 840                 845             


<210>  36
<211>  2493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       N-VP1 fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  36
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtgag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgggaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagacggcgc cgcgggagca ggtgcaggag atagggtggc agatgtaatt     1620

gaaagctcca taggagatag cgtgagcaga gccctcactc acgctctacc agcacccaca     1680

ggtcagaaca cacaggtgag cagtcatcga ctggatacgg gcaaggttcc agcactccaa     1740

gctgctgaaa ttggagcatc atcaaatgct agtgacgaga gtatgattga gacacgctgt     1800

gtcctcaact cgcacagtac agcagagacc actcttgata gtttcttcag cagggcggga     1860

ttagttggag agatagatct ccctcttgag ggcacaacta acccaaatgg ttatgccaac     1920

tgggacatag atataacagg ttacgcgcaa atgcgtagaa aggtagagct cttcacctac     1980

atgcgctttg atgcagagtt cacttttgtt gcgtgtacac ctaccgggga agttgttcca     2040

caactgctcc aatatatgtt tgtgccacct ggagccccaa agccagattc tagggaatcc     2100

cttgcatggc aaaccgccac taacccctca gtttttgtca agctgtcaga ccctccagca     2160

caggtttcag tgccattcat gtcacctgcg agtgcttatc aatggtttta tgacggatat     2220

cccacgttcg gagaacacaa acaggagaaa gatcttgaat atggggcatg tcctaataac     2280

atgatgggca cgttctcagt gcggactgta gggtcctcca agtccaagta ccctctagtg     2340

attaggattt acatgagaat gaagcacgtc agggcgtgga tacctcgccc gatgcgtaac     2400

cagaactacc tattcaaagc caatccaaat tatgctggca actccgttaa gccaactggt     2460

gccagtcgca cagcgatcac cactctttga tga                                  2493


<210>  37
<211>  2493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       N-VP1 fusion protein (the nucleoprotein N is obtained from the 
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  37
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cggaaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagatggcgc cgcgggtgct ggtgccggag atagagtcgc cgatgttatt     1620

gagtcttcca ttggagattc agttagtaga gccttgacac acgccttgcc agccccaacc     1680

ggacaaaaca ctcaggtttc ttcccataga ttggatacag gaaaggtccc tgctcttcaa     1740

gctgccgaga ttggtgcctc aagtaacgca tctgacgaat ccatgatcga gactagatgt     1800

gttttgaatt cacacagtac agctgaaact acattggatt catttttcag tagagccggt     1860

cttgttggag agattgactt gccacttgaa ggtaccacta accctaatgg atacgccaac     1920

tgggatattg acatcactgg ttatgcacag atgagaagaa aagttgagtt gtttacctac     1980

atgagattcg atgcagaatt cactttcgtt gcttgcacac caaccggaga ggttgtccct     2040

caattgcttc agtatatgtt tgttccacct ggtgctccaa agcctgattc tagagaatcc     2100

ttggcttggc aaactgccac aaatccatcc gtttttgtca aactttcaga cccacctgct     2160

caagtttctg tcccattcat gtcacctgca agtgcttacc agtggtttta cgatggttat     2220

ccaactttcg gagaacataa gcaggagaaa gacttggaat atggtgcttg tcctaacaat     2280

atgatgggaa cattttctgt tagaaccgtc ggttcttcca agtccaagta cccattggtt     2340

attagaatct atatgagaat gaagcacgtc agagcatgga tcccaagacc tatgagaaac     2400

caaaattacc ttttcaaagc taaccctaat tatgcaggaa actcagtcaa gcctacagga     2460

gcatcaagaa ccgccatcac aacactttag taa                                  2493


<210>  38
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the polynucleotide encoding the N-VP1 
       fusion protein (the nucleoprotein N is obtained from the Schwarz 
       strain) including the amino acid sequence of the peptide linker 
       disclosed as sequence SEQ ID No: 27

<400>  38

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp Gly Ala Ala 
        515                 520                 525             


Gly Ala Gly Ala Gly Asp Arg Val Ala Asp Val Ile Glu Ser Ser Ile 
    530                 535                 540                 


Gly Asp Ser Val Ser Arg Ala Leu Thr His Ala Leu Pro Ala Pro Thr 
545                 550                 555                 560 


Gly Gln Asn Thr Gln Val Ser Ser His Arg Leu Asp Thr Gly Lys Val 
                565                 570                 575     


Pro Ala Leu Gln Ala Ala Glu Ile Gly Ala Ser Ser Asn Ala Ser Asp 
            580                 585                 590         


Glu Ser Met Ile Glu Thr Arg Cys Val Leu Asn Ser His Ser Thr Ala 
        595                 600                 605             


Glu Thr Thr Leu Asp Ser Phe Phe Ser Arg Ala Gly Leu Val Gly Glu 
    610                 615                 620                 


Ile Asp Leu Pro Leu Glu Gly Thr Thr Asn Pro Asn Gly Tyr Ala Asn 
625                 630                 635                 640 


Trp Asp Ile Asp Ile Thr Gly Tyr Ala Gln Met Arg Arg Lys Val Glu 
                645                 650                 655     


Leu Phe Thr Tyr Met Arg Phe Asp Ala Glu Phe Thr Phe Val Ala Cys 
            660                 665                 670         


Thr Pro Thr Gly Glu Val Val Pro Gln Leu Leu Gln Tyr Met Phe Val 
        675                 680                 685             


Pro Pro Gly Ala Pro Lys Pro Asp Ser Arg Glu Ser Leu Ala Trp Gln 
    690                 695                 700                 


Thr Ala Thr Asn Pro Ser Val Phe Val Lys Leu Ser Asp Pro Pro Ala 
705                 710                 715                 720 


Gln Val Ser Val Pro Phe Met Ser Pro Ala Ser Ala Tyr Gln Trp Phe 
                725                 730                 735     


Tyr Asp Gly Tyr Pro Thr Phe Gly Glu His Lys Gln Glu Lys Asp Leu 
            740                 745                 750         


Glu Tyr Gly Ala Cys Pro Asn Asn Met Met Gly Thr Phe Ser Val Arg 
        755                 760                 765             


Thr Val Gly Ser Ser Lys Ser Lys Tyr Pro Leu Val Ile Arg Ile Tyr 
    770                 775                 780                 


Met Arg Met Lys His Val Arg Ala Trp Ile Pro Arg Pro Met Arg Asn 
785                 790                 795                 800 


Gln Asn Tyr Leu Phe Lys Ala Asn Pro Asn Tyr Ala Gly Asn Ser Val 
                805                 810                 815     


Lys Pro Thr Gly Ala Ser Arg Thr Ala Ile Thr Thr Leu 
            820                 825                 


<210>  39
<211>  1986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       N-Avidin fusion protein (the nucleoprotein N is obtained from the
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  39
atggccacac ttttaaggag cttagcattg ttcaaaagaa acaaggacaa accacccatt       60

acatcaggat ccggtggagc catcagagga atcaaacaca ttattatagt accaatccct      120

ggagattcct caattaccac tcgatccaga cttctggacc ggttggtgag gttaattgga      180

aacccggatg tgagcgggcc caaactaaca ggggcactaa taggtatatt atccttattt      240

gtggagtctc caggtcaatt gattcagagg atcaccgatg accctgacgt tagcataagg      300

ctgttagagg ttgtccagag tgaccagtca caatctggcc ttaccttcgc atcaagaggt      360

accaacatgg aggatgaggc ggaccaatac ttttcacatg atgatccaat tagtagtgat      420

caatccaggt tcggatggtt cgggaacaag gaaatctcag atattgaagt gcaagaccct      480

gagggattca acatgattct gggtaccatc ctagcccaaa tttgggtctt gctcgcaaag      540

gcggttacgg ccccagacac ggcagctgat tcggagctaa gaaggtggat aaagtacacc      600

caacaaagaa gggtagttgg tgaatttaga ttggagagaa aatggttgga tgtggtgagg      660

aacaggattg ccgaggacct ctccttacgc cgattcatgg tcgctctaat cctggatatc      720

aagagaacac ccggaaacaa acccaggatt gctgaaatga tatgtgacat tgatacatat      780

atcgtagagg caggattagc cagttttatc ctgactatta agtttgggat agaaactatg      840

tatcctgctc ttggactgca tgaatttgct ggtgagttat ccacacttga gtccttgatg      900

aacctttacc agcaaatggg ggaaactgca ccctacatgg taatcctgga gaactcaatt      960

cagaacaagt tcagtgcagg atcataccct ctgctctgga gctatgccat gggagtagga     1020

gtggaacttg aaaactccat gggaggtttg aactttggcc gatcttactt tgatccagca     1080

tattttagat tagggcaaga gatggtaagg aggtcagctg gaaaggtcag ttccacattg     1140

gcatctgaac tcggtatcac tgccgaggat gcaaggcttg tttcagagat tgcaatgcat     1200

actactgagg acaagatcag tagagcggtt ggacccagac aagcccaagt atcatttcta     1260

cacggtgatc aaagtgagaa tgagctaccg agattggggg gcaaggaaga taggagggtc     1320

aaacagagtc gaggagaagc cagggagagc tacagagaaa ccgggcccag cagagcaagt     1380

gatgcgagag ctgcccatct tccaaccggc acacccctag acattgacac tgcaacggag     1440

tccagccaag atccgcagga cagtcgaagg tcagctgacg ccctgcttag gctgcaagcc     1500

atggcaggaa tctcggaaga acaaggctca gacacggaca cccctatagt gtacaatgac     1560

agaaatcttc tagacggcgc cgcgggagca ggtgcagcca gaaagtgctc gctgactggg     1620

aaatggacca acgatctggg ctccaacatg accatcgggg ctgtgaacag cagaggtgaa     1680

ttcacaggca cctacatcac agccgtaaca gccacatcaa atgagatcaa agagtcacca     1740

ctgcatggga cacaaaacac catcaacaag aggacccagc ccacctttgg cttcaccgtc     1800

aattggaagt tttcagagtc caccactgtc ttcacgggcc agtgcttcat agacaggaat     1860

gggaaggagg tcctgaagac catgtggctg ctgcggtcaa gtgttaatga cattggtgat     1920

gactggaaag ctaccagggt cggcatcaac atcttcactc gcctgcgcac acagaaggag     1980

tagtag                                                                1986


<210>  40
<211>  1986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized nucleotide sequence of the polynucleotide encoding the 
       N-avidin fusion protein (the nucleoprotein N is obtained from the
       Schwarz strain) including the nucleotide sequence encoding the 
       peptide linker disclosed as sequence SEQ ID No: 26

<400>  40
atggccacgt tattgagatc tttagccctt tttaagagga acaaggacaa acccccaatt       60

acaagtggtt ctggtggagc tattcgtggt attaagcaca ttattatcgt gcccattcca      120

ggggattcaa gtatcaccac ccgaagtaga ttgttggaca gattggtccg acttataggg      180

aacccagacg ttagtggacc caagctgacc ggggctctga tcggaatctt atctttgttc      240

gttgaatctc caggacagtt aatccaaagg attacagacg atccagacgt ctctattagg      300

cttctagagg ttgttcagtc tgaccagtct caatccggtc ttaccttcgc ttcaagaggt      360

accaatatgg aggacgaagc cgatcaatat ttctcacatg acgatcctat ctcctccgac      420

caatcaagat ttggttggtt cggaaacaaa gagatctctg acattgaggt tcaggaccca      480

gaaggattta acatgatact gggaactatc cttgcacaaa tctgggtgct gctggctaaa      540

gccgttactg ctccagacac cgctgctgat tccgaattac gaagatggat taaatacact      600

caacaacgta gagtagttgg tgaatttaga ttggagagaa agtggttgga tgttgtgaga      660

aacagaattg cagaagacct atcactgaga cgatttatgg tcgctcttat actggatatt      720

aagaggacac caggaaacaa gccaaggatt gcagaaatga tctgtgatat agatacttac      780

atcgttgagg ccgggttggc ttcctttatt ctaactataa aatttggtat cgagacaatg      840

tacccagcat tgggattgca tgagttcgcc ggagaactgt caacattgga gtcattgatg      900

aatctatacc agcaaatggg tgaaacagct ccatatatgg tcattctgga aaactccatt      960

caaaacaagt tttcagccgg ttcataccca ttattgtggt cttacgccat gggagtcggt     1020

gtagagctgg aaaactctat gggtggcctt aatttcggca gatcttattt tgatcccgct     1080

tattttagac tgggccaaga gatggtcaga cgttctgccg gaaaggtttc tagtactttg     1140

gctagtgaac taggtataac tgctgaggac gctagattgg tttctgaaat agctatgcac     1200

actactgaag ataagatcag tagggccgtt ggccctaggc aagctcaggt gtccttctta     1260

catggtgatc aatccgagaa tgagttgcct cgattgggag gcaaagagga ccgtagagtt     1320

aaacaatcta gaggagaggc acgtgaatct tacagagaga ccggtccatc ccgagcttct     1380

gatgcacgag ccgctcatct tcctaccggt acacctttag acattgatac ggcaacggaa     1440

tcatcccagg atccccaaga ttctagacgt tctgctgatg ctttactaag attgcaggct     1500

atggccggaa tttcagagga gcaaggttcc gacacagata ctccaattgt ctataatgac     1560

cgaaatctgt tagatggcgc cgcgggtgct ggtgccgcta gaaaatgttc acttactgga     1620

aaatggacaa atgaccttgg ttcaaatatg acaatcggtg ctgttaatag tcgtggtgaa     1680

ttcactggaa cttacattac tgctgttaca gccacctcta acgaaatcaa ggagtcccca     1740

ttgcatggta ctcaaaacac tattaacaag agaacccagc ctacttttgg attcacagtt     1800

aattggaagt tctcagaaag tactacagtc tttactggtc aatgtttcat tgatagaaac     1860

ggaaaggagg ttcttaaaac tatgtggttg cttagatctt ccgtcaatga catcggagat     1920

gactggaagg caaccagagt cggtattaac attttcacaa gattgagaac ccagaaggag     1980

tagtaa                                                                1986


<210>  41
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the polynucleotide encoding the N-Avidin 
       fusion protein (the nucleoprotein N is obtained from the Schwarz 
       strain) including the amino acid sequence of the peptide linker 
       disclosed as sequence SEQ ID No: 27

<400>  41

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp Gly Ala Ala 
        515                 520                 525             


Gly Ala Gly Ala Ala Arg Lys Cys Ser Leu Thr Gly Lys Trp Thr Asn 
    530                 535                 540                 


Asp Leu Gly Ser Asn Met Thr Ile Gly Ala Val Asn Ser Arg Gly Glu 
545                 550                 555                 560 


Phe Thr Gly Thr Tyr Ile Thr Ala Val Thr Ala Thr Ser Asn Glu Ile 
                565                 570                 575     


Lys Glu Ser Pro Leu His Gly Thr Gln Asn Thr Ile Asn Lys Arg Thr 
            580                 585                 590         


Gln Pro Thr Phe Gly Phe Thr Val Asn Trp Lys Phe Ser Glu Ser Thr 
        595                 600                 605             


Thr Val Phe Thr Gly Gln Cys Phe Ile Asp Arg Asn Gly Lys Glu Val 
    610                 615                 620                 


Leu Lys Thr Met Trp Leu Leu Arg Ser Ser Val Asn Asp Ile Gly Asp 
625                 630                 635                 640 


Asp Trp Lys Ala Thr Arg Val Gly Ile Asn Ile Phe Thr Arg Leu Arg 
                645                 650                 655     


Thr Gln Lys Glu 
            660 


<210>  42
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of MV Schwarz Leader sequence (including the 
       N start codon ATG)

<400>  42
accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat       60

tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg                 110


<210>  43
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of MV Schwarz Trailer sequence

<400>  43
accagacaaa gctgggaata gaaacttcgt attttcaaag ttttctttaa tatattgcaa       60

ataatgccta accacctagg gcaggattag ggttccggag ttcaaccaat ta              112


