                         SEQUENCE LISTING

<110>  U.S. ARMY MEDICAL RESEARCH
 
<120>  AMA-1 EPITOPES, ANTIBODIES, COMPOSITIONS, AND METHODS OF MAKING 
       AND USING THE SAME

<130>  27533WO01

<150>  US 61/902521
<151>  2013-11-11

<150>  US 61/921031
<151>  2013-12-26

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of 1 e loop AMA protein

<400>  1

Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr 
1               5                   10          


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Domain 3 region of AMA-1

<400>  2

Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
1               5                   10                  15      


Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
            20                  25                  30          


Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
        35                  40                  45              


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
    50                  55                  60                  


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser 
65                  70                  75                  80  


Asn Ser Thr Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg Arg Ala 
                85                  90                  95      


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
            100                 105                 110         


Glu 
    


<210>  3
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of FVO AMA-1 protein

<400>  3

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Pro Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Lys Pro Val Ala Thr Gly Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Asn Pro Leu Ile Ser Pro Met Thr 
            100                 105                 110         


Leu Asn Gly Met Arg Asp Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Arg Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  4
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of HB3 AMA-1 protein

<400>  4

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Lys Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Ile Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Gln Met Arg His Leu Tyr Lys Asp Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Glu Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Asn Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  5
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of W2Mef AMA-1 protein

<400>  5

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Lys Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Asp Met Arg Leu Leu Tyr Lys Asp Asn Glu Asp Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Ser Phe Gln Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Arg Lys Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Ile Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  6
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of 3D7 AMA-1 protein

<400>  6

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Ile Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Asp 
145                 150                 155                 160 


Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  7
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of 7G8 AMA1

<400>  7

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Lys Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Lys Pro Val Ala Thr Gly Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Asn Pro Leu Ile Ser Pro Met Thr 
            100                 105                 110         


Leu Asp His Met Arg Asp Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Ser Phe Gln Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Arg Lys Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Asn Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Ile Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  8
<211>  1358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7G8 AMA-1 nucleic acid sequence

<400>  8
ggcgcagaac cagcaccgca agaacagaac ttattcagca gcattgagat tgtcgagcgc       60

tccaattaca tgggcaaccc gtggaccgag tacatggcca agtatgacat taaagaggtc      120

cacggtagcg gcattcgtgt ggacctgggc gaagatgcgg aagtagcagg tacccagtac      180

cgcttgccga gcggcaaatg cccggttttc ggcaaaggta tcatcatcga gaactctaac      240

accaccttcc tgaagccggt tgccaccggt aatcaagatc tgaaggacgg cggttttgcc      300

tttccgccga ccaacccact gattagccct atgacgctgg atcacatgcg tgacttttac      360

aaaaacaacg agtacgtgaa gaaccttgat gaactgacgc tgtgtagccg tcatgcgggt      420

aatatgaatc cggacaatga taagaatagc aactacaaat acccggcagt ttatgactat      480

aatgacaaga aatgccatat tctgtacatt gcggcacaag agaataatgg tccgcgttat      540

tgtaacaaag atgaaagcaa acgcaacagc atgttctgtt ttcgtccggc aaaggataaa      600

agcttccaaa actacaccta tctgagcaaa aacgttgtgg acaactggga gaaagtttgc      660

ccgcgtaaaa acttggagaa cgccaagttc ggtctgtggg tggacggcaa ttgcgaggat      720

atcccgcacg tcaatgaatt cagcgcgaat gacctgttcg agtgcaataa gttagttttt      780

gagctgagcg ctagcgacca gccgaagcag tacgagcagc acctgaccga ctatgagaag      840

atcaaagaag gtttcaagaa caagaatgca tccatgatca aaagcgcctt tcttccaact      900

ggcgcgttca aagctgatcg ttacaagagc cgtggtaaag gctataactg gggcaactat      960

aatcgtaaga cgcagaagtg tgagattttc aatgtaaagc cgacgtgcct gatcaataac     1020

agcagctaca tcgccacgac cgcgctgagc cacccgaacg aggtggagca taactttccg     1080

tgcagcctgt ataaggacga gatcaagaag gagatcgaac gcgagtccaa acgcatcaag     1140

ctgaatgata acgacgatga gggtaacaag aagattatcg ctccgagaat tttcatttct     1200

gatgatattg acagcttgaa gtgcccgtgt gatccggaaa tcgtttcgaa tagcacctgc     1260

aatttctttg tgtgcaaatg tgtcgagaaa cgcgcagagg tcaccagcaa taacgaggtc     1320

gtggtcaaag aggaatacaa agacgagtaa gcggccgc                             1358


<210>  9
<211>  1358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M24 AMA-1 nucleic acid acid sequence

<400>  9
ggtgcggagc cagccccgca ggagcaaaat ctgttcagct ccattgagat tgtcgaacgc       60

tctaactata tgggcaatcc atggaccgag tatatggcga agtacgatat tgaagaagtg      120

cacggttccg gtattcgtgt tgatttgggt gaggatgcgg aggtcgctgg cacccagtac      180

cgtttgccga gcggtaagtg cccggttttt ggcaaaggta tcatcatcga aaacagcaac      240

accacctttc tgactccggt cgcaacggaa aatcaggacc tgaaggacgg tggttttgcg      300

tttccgccga cgaaaccgct gatgtccccg atgacgctgg atcaaatgcg tgatttctac      360

aaaaacaatg aatatgtcaa aaacctggac gagctgacgt tgtgctctcg ccacgccggt      420

aacatgaatc cggataacga cgagaatagc aactataagt atccggcagt gtatgattac      480

aaagacaaga aatgccatat cctgtacatt gcagcacaag aaaacaatgg tccgcgttac      540

tgcaacaaag atcagagcaa acgcaacagc atgttctgct ttcgtcctgc aaaggataag      600

ctgttcgaga attacaccta tctgagcaaa aacgtggtgc acaattggga gaaggtgtgt      660

cctcgtaaga atctgcagaa cgcgaaattc ggcctgtggg tcgacggtaa ctgtgaggac      720

atcccgcatg tgaacgaatt cagcgcgaac gatctgttcg aatgcaacaa gctggtcttt      780

gaactgtccg ccagcgatca accgaagcaa tacgaacagc atctgaccga ctacgagaag      840

atcaaagagg gtttcaaaaa caagaacgca agcatgatta agtccgcgtt tttgccgacg      900

ggtgcgttta aggccgaccg ctacaagagc cgtggcaaag gctacaattg gggtaactac      960

aataccaaaa ctcaaaagtg tgagatcttt aacgtgaaac caacgtgtct gattaacaat     1020

agctcttaca tcgcgaccac cgcgttgagc cacccgattg aggtggaaca caatttcccg     1080

tgtagcttgt ataaggacga gattaagaaa gagatcgagc gtgagagcaa gcgcatcaag     1140

ctgaacgata atgatgacga gggcaataag aagattatcg caccgcgtat cttcattagc     1200

gacgacattg atagcctgaa atgtccgtgt gacccggaga tggtcagcaa cagcacttgc     1260

cgcttctatg tctgcaagtg cgttgagcgt cgtgctgagg tgaccagcaa caacgaggtc     1320

gtggttaaag aagaatacaa ggatgagtga gcggccgc                             1358


<210>  10
<211>  1358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HB3 AMA-1 nucleic acid sequence

<400>  10
ggtgcggagc cggcaccgca ggagcagaat ctgttttcct ctatcgagat tgttgagcgt       60

agcaattaca tgggcaatcc gtggaccgag tatatggcca agtacgacat cgagaaagtt      120

catggcagcg gtatccgcgt cgatctgggc gaagatgcgg aggttgcagg cacccaatac      180

cgcctgccgt ctggtaaatg ccctgttttc ggtaaaggca ttatcatcga aaatagcaaa      240

acgacctttc tgaccccggt tgcaactgag aaccaagacc tgaaagacgg tggcttcgcc      300

tttccgccga ccgagccatt gatttccccg atgacgctgg accagatgcg tcacctgtat      360

aaggacaatg agtacgtgaa aaatctggat gaactgaccc tgtgctcgcg tcacgcgggt      420

aacatgaatc cggacaacga taagaatagc aactataagt atccagcagt ctacgattac      480

gaggacaaga agtgccatat tctgtacatt gcggcacaag aaaacaatgg tccgcgttat      540

tgtaacaagg atgagtctaa acgtaattcc atgttctgct ttcgtccggc gaaagataaa      600

ctgttcgaaa actataccta cttgagcaag aatgtggtgg acaactggga agaggtctgt      660

ccgcgtaaga acttggaaaa cgctaaattc ggtctgtggg tggatggtaa ctgtgaagat      720

attccgcacg tgaatgagtt cagcgcgaat gatctgtttg aatgcaacaa actggtcttt      780

gagttgagcg cgagcgacca gccgaaacaa tatgaacagc acttgaccga ttacgaaaag      840

atcaaggaag gttttaagaa taagaacgcg agcatgatca aaagcgcatt tctgccgacc      900

ggtgcgttca aagccgaccg ctacaagagc cgcggtaaag gttataactg gggcaattac      960

aacaccgaaa cgcaaaaatg cgagatcttc aacgtgaaac cgacttgtct gatcaacaat     1020

tctagctaca ttgctacgac cgccctgagc catccaaacg aagttgagaa caactttccg     1080

tgcagcctgt ataaagacga gatcaaaaag gagatcgaac gtgaatccaa gcgcattaaa     1140

ctgaatgaca acgacgatga gggcaataag aaaatcattg ctccgcgtat tttcattagc     1200

gatgacaagg acagcctgaa gtgtccgtgt gatcctgaga ttgtcagcaa tagcacgtgt     1260

aatttcttcg tgtgcaagtg cgttgaaaag cgtgcggaag ttacgagcaa caacgaggtc     1320

gtggttaagg aagagtacaa agacgagtaa gcggccgc                             1358


<210>  11
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W2mef AMA-1 nucleic acid sequence

<400>  11
ggtgccgagc cagcgccgca agaacagaac ttgtttagct ccattgagat tgtagagcgt       60

agcaactaca tgggtaaccc gtggaccgaa tacatggcga agtatgatat tgaggaagtt      120

cacggcagcg gcattcgtgt tgacttgggt gaggacgctg aagtcgccgg cacccagtac      180

cgtctgccgt ctggtaaatg cccggtgttt ggcaaaggca tcatcatcga gaatagcaat      240

accacctttc tgacccctgt tgcgacgggc aatcagtatc tgaaagatgg tggcttcgcg      300

tttccgccga cgaagccgct gatgagcccg atgacgctgg atgacatgcg tctgctgtac      360

aaagataacg aggatgtgaa aaacctggac gaactgacgt tgtgtagccg tcatgcgggt      420

aatatgaacc cggacaacga caaaaactcc aattacaagt atccggcggt ctatgattac      480

aatgataaga agtgtcacat cctgtatatt gcggcccaag agaacaacgg tccgcgttac      540

tgcaacaaag acgaaagcaa acgtaacagc atgttttgct tccgtccggc taaagacaaa      600

tctttccaga attacaccta tctgtcgaaa aacgtcgtgg acaactggga ggaagtttgt      660

ccgcgtaaaa acttggagaa tgcaaaattc ggtctgtggg ttgacggtaa ctgtgaagat      720

attccgcatg tgaacgagtt tagcgcaaat gatctgtttg aatgtaacaa gttggttttc      780

gaactgtccg cgagcgatca acctaagcag tacgagcagc atctgaccga ctacgagaag      840

atcaaagagg gcttcaagaa caagaatgcc agcatgatca agagcgcgtt cctgccgacc      900

ggtgccttta aagcagaccg ctacaagagc cacggtaagg gttacaattg gggtaattac      960

aatcgcaaga ctcaaaaatg tgaaatcttc aatgtgaaac cgacctgcct gatcaacaat     1020

agcagctata ttgcaaccac ggcgctgagc cacccgattg aagtggagca caacttcccg     1080

tgcagcctgt ataaagatga gatcaaaaag gagatcgagc gcgaatcgaa gcgtattaag     1140

ctgaatgaca atgacgatga aggcaataag aagattatcg caccacgcat cttcatctct     1200

gacgacattg atagcctgaa atgcccgtgc gatccggaga ttgtctccaa cagcacctgc     1260

aatttctttg tttgcaaatg tgtggaaaag cgcgcagagg ttacgagcaa caatgaggtg     1320

gtcgtcaaag aagagtataa ggacgaa                                         1347


<210>  12
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  102-1 AMA-1 nucleic acid sequence

<400>  12
ggcgcagaac cagcaccgca ggaacagaac ttattcagct ccatcgagat tgtagaacgt       60

agcaactaca tgggtaatcc gtggaccgag tacatggcga agtatgatat cgaagaggtg      120

catggtagcg gcattcgcgt ggatttgggc gaggatgcgg aggttgcggg tacccaatac      180

cgcctgccgt ctggtaagtg cccggttttt ggcaaaggta tcatcatcga aaactctaac      240

actacctttc tgacgccggt cgccaccgag aacaaagacc tgaaggacgg tggctttgcc      300

ttcccgccga ccgagccgct gatgtcgccg atgaccctgg acgatatgcg tcgtttctac      360

aaagacaatg aatatgtgaa gaatctggat gagctcaccc tgtgttcccg ccacgccggt      420

aacatgaatc cggacaatga caaaaacagc aactataagt acccggcagt ttacgattac      480

aacgataaga agtgtcacat cctttacatc gcagcgcagg aaaacaatgg tccgcgctac      540

tgcaacaaag atcagagcaa gcgtaatagc atgttctgtt tccgtccggc aaaagataag      600

ctgttcgaga attacacgta tctgtcgaag aatgtggttg acaactggga agaagtctgc      660

ccgcgtaaga acctcgagaa cgcaaagttc ggtctgtggg tcgacggcaa ctgcgaggac      720

attccgcatg ttaatgagtt tagcgcgaat gacctgttcg aatgcaacaa actggtgttt      780

gagctgagcg cttccgatca accgaagcag tacgaacagc atctgaccga ctacgagaaa      840

atcaaagaag gtttcaaaaa caaaaacgcg tctatgatta agagcgcgtt tctgccaacc      900

ggtgccttta aggcggaccg ttacaagagc cacggcaaag gttacaactg gggtaactac      960

aatcgcgaaa cccagaaatg cgagatcttc aatgtcaaac cgacgtgtct gatcaataac     1020

tctagctaca tcgcgacgac cgcgctgagc cacccgaacg aagttgaaca caatttcccg     1080

tgtagcctgt acaaagatga gatcaagaaa gaaatcgaga gagaaagcaa acgcatcaag     1140

ctgaacgaca acgatgatga gggcaacaag aagatcatcg caccgcgcat ctttatcagc     1200

gatgacattg actccctgaa atgcccttgc gatccagaga tcgtttccaa cagcacttgc     1260

aatttcttcg tctgcaagtg cgtggagaag cgtgcggagg tgacgtctaa caatgaggtt     1320

gtggttaaag aagagtacaa agacgag                                         1347


<210>  13
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVO AMA-1 nucleic acid sequence

<400>  13
ggcgcggaac cggcgccgca ggaacagaac ctgtttccga gcattgaaat tgtggaacgc       60

agcaactata tgggcaaccc gtggaccgaa tatatggcga aatatgatat tgaagaagtg      120

catggcagcg gcattcgcgt ggatctgggc gaagatgcgg aagtggcggg cacccagtat      180

cgcctgccga gcggcaaatg cccggtgttt ggcaaaggca ttattattga aaacagcaac      240

accacctttc tgaaaccggt ggcgaccggc aaccaggatc tgaaagatgg cggctttgcg      300

tttccgccga ccaacccgct gattagcccg atgaccctga acggcatgcg cgatttttat      360

aaaaacaacg aatatgtgaa aaacctggat gaactgaccc tgtgcagccg ccatgcgggc      420

aacatgaacc cggataacga taaaaacagc aactataaat atccggcggt gtatgattat      480

aacgataaaa aatgccatat tctgtatatt gcggcgcagg aaaacaacgg cccgcgctat      540

tgcaacaaag atcagagcaa acgcaacagc atgttttgct ttcgcccggc gaaagataaa      600

ctgtttgaaa actataccta tctgagcaaa aacgtggtgg ataactggga agaagtgtgc      660

ccgcgcaaaa acctggaaaa cgcgaaattt ggcctgtggg tggatggcaa ctgcgaagat      720

attccgcatg tgaacgaatt tagcgcgaac gatctgtttg aatgcaacaa actggtgttt      780

gaactgagcg cgagcgatca gccgaaacag tatgaacagc atctgaccga ttatgaaaaa      840

attaaagaag gctttaaaaa caaaaacgcg agcatgatta aaagcgcgtt tctgccgacc      900

ggcgcgttta aagcggatcg ctataaaagc catggcaaag gctataactg gggcaactat      960

aaccgcgaaa cccagaaatg cgaaattttt aacgtgaaac cgacctgcct gattaacaac     1020

agcagctata ttgcgaccac cgcgctgagc catccgattg aagtggaaca taactttccg     1080

tgcagcctgt ataaagatga aattaaaaaa gaaattgaac gcgaaagcaa acgcattaaa     1140

ctgaacgata acgatgatga aggcaacaaa aaaattattg cgccgcgcat ttttattagc     1200

gatgataaag atagcctgaa atgcccgtgc gatccggaaa tggtgagcaa cagcacctgc     1260

cgcttttttg tgtgcaaatg cgtggaacgc cgcgcggaag tgaccagcaa caacgaagtg     1320

gtggtgaaag aagaatataa agatgaa                                         1347


<210>  14
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric protein AMA-1: FVO(D1)+ 3D7 (D2+3)

<400>  14

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Pro Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Lys Pro Val Ala Thr Gly Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Asn Pro Leu Ile Ser Pro Met Thr 
            100                 105                 110         


Leu Asn Gly Met Arg Asp Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  15
<211>  1343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence of chimeric protein AMA-1: FVO(D1)+ 3D7 
       (D2+3)

<400>  15
ggcgcggaac cggcgccgca ggaacagaac ctgtttccga gcattgaaat tgtggaacgc       60

agcaactata tgggcaaccc gtggaccgaa tatatggcga aatatgatat tgaagaagtg      120

catggcagcg gcattcgcgt ggatctgggc gaagatgcgg aagtggcggg cacccagtat      180

cgcctgccga gcggcaaatg cccggtgttt ggcaaaggca ttattattga aaacagcaac      240

accacctttc tgaaaccggt ggcgaccggc aaccaggatc tgaaagatgg cggctttgcg      300

tttccgccga ccaacccgct gattagcccg atgaccctga acggcatgcg cgatttttat      360

aaaaacaacg aatatgtgaa aaacctggat gaactgaccc tgtgcagccg ccatgcgggc      420

aacatgaacc cggataacga taaaaacagc aactataaat atccggcggt gtatgattat      480

aacgataaaa aatgccatat tctgtatatt gcggcgcagg aaaacaacgg cccgcgctat      540

tgcaacaaag atcagagcat acgcaacagc atgttttgct ttcgcccggc gaaagataaa      600

ctgtttgaaa actataccta tctgagcaaa aacgtggtgg ataactggga agaagtgtgc      660

ccgcgtaaaa acctggaaaa cgcgaaattt ggcctgtggg tggatggcaa ctgcgaagat      720

attccgcatg tgaacgaatt tagcgcgaac gatctgtttg aatgcaacaa actggtgttt      780

gaactgagcg cgagcgatca gccgaaacag tatgaacagc atctgaccga ttatgaaaaa      840

attaaagaag gctttaaaaa caaaaacgcg agcatgatta aaagcgcgtt tctgccgacc      900

ggcgcgttta aagcggatcg ttataaaagc cacggcaaag gctataactg gggcaactat      960

aacaccgaaa cccagaaatg cgaaattttt aacgtgaaac cgacctgcct gattaacaac     1020

agcagctata ttgcgaccac cgcgctgagc catccgattg aagtggaaaa caactttccg     1080

tgcagcctgt ataaagatga aattatgaaa gaaattgaac gtgaaagcaa acgtattaaa     1140

ctgaacgata acgatgatga aggcaacaaa aaaattattg cgccgcgtat ttttattagc     1200

gatgataaag atagcctgaa atgcccgtgc gatccggaaa tggtgagcaa cagcacctgc     1260

cgtttttttg tgtgcaaatg cgtggaacgt cgtgcggaag tgaccagcaa caacgaagtg     1320

gtggtgaaag aagaatataa aga                                             1343


<210>  16
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric protein of AMA-1: HB3(D1) + W2(D2+3)

<400>  16

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Lys Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Ile Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Gln Met Arg His Leu Tyr Lys Asp Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Glu Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Arg Lys Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Ile Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  17
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of chimeric protein of AMA-1: HB3(D1) + 
       W2(D2+3)

<400>  17
ggcgcagaac cagcacctca agagcaaaac ctgtttagca gcattgagat cgtggagcgt       60

tctaactaca tgggtaatcc ttggacggag tatatggcca agtatgacat cgaaaaggtg      120

catggtagcg gtattcgtgt tgacctgggt gaggacgcgg aggttgccgg cactcaatac      180

cgtctgccga gcggtaaatg tccggttttt ggcaagggta tcattatcga gaattcgaaa      240

accacctttt tgaccccggt ggctacggaa aatcaggatc tgaaagacgg cggtttcgca      300

ttcccgccga ctgaacctct gatcagcccg atgacgctgg accagatgcg tcatttgtat      360

aaggataacg aatacgtgaa aaacttggac gaactgaccc tgtgcagccg tcacgccggt      420

aacatgaacc cggataatga caaaaacagc aactacaagt atccggcggt ttatgactac      480

gaggacaaaa agtgtcacat tctgtacatc gctgcgcagg aaaacaatgg ccctcgctac      540

tgcaataagg acgagtccaa gcgcaatagc atgttttgtt tccgtccggc caaggacaag      600

ctgttcgaga actataccta cctgtcgaaa aacgtggttg acaactggga agaagtttgt      660

ccgcgtaaga acctggaaaa cgcgaagttc ggcctgtggg ttgatggtaa ctgtgaggac      720

atcccgcacg tcaacgagtt ctcggcaaac gatctgtttg agtgcaacaa actggttttt      780

gaactgagcg cgagcgacca gccgaaacag tatgagcagc acctgacgga ttacgaaaag      840

atcaaagaag gtttcaagaa caagaacgcc tccatgatca agtctgcatt cttgccgact      900

ggcgcgttta aggcggaccg ctacaagtct catggtaaag gctacaactg gggcaattac      960

aaccgcaaaa cccagaaatg cgagattttc aacgttaagc cgacgtgtct gatcaataac     1020

agctcgtaca tcgcgaccac ggcgctgagc catccgatcg aggttgaaca caactttccg     1080

tgtagcctgt acaaagatga gatcaagaaa gagatcgaac gtgaaagcaa gcgcattaag     1140

ctgaacgata acgacgacga gggcaataag aagattatcg cccctcgtat cttcattagc     1200

gatgacatcg actccctgaa atgcccgtgc gatccggaaa ttgtcagcaa tagcacgtgc     1260

aacttctttg tgtgtaagtg cgtcgagaaa cgtgcggaag ttacctccaa caatgaggtc     1320

gtggtgaaag aagagtataa ggatgag                                         1347


<210>  18
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence chimeric protein of AMA-1 W2(D1) + HB3 (D2+3)

<400>  18

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Lys Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Asp Met Arg Leu Leu Tyr Lys Asp Asn Glu Asp Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Ser Phe Gln Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Asn Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  19
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence chimeric protein of AMA-1 W2(D1) + HB3 (D2+3)

<400>  19
ggcgcagaac cagcacctca agagcaaaac ctgtttagca gcattgagat cgtggagcgt       60

tctaactaca tgggtaatcc ttggacggag tatatggcca agtatgacat cgaagaggtg      120

catggtagcg gtattcgtgt tgacctgggt gaggacgcgg aggttgccgg cactcaatac      180

cgtctgccga gcggtaaatg tccggttttt ggcaagggta tcattattga aaatagcaac      240

accacctttt tgaccccggt ggctacgggt aatcagtatc tcaaagacgg cggtttcgca      300

ttcccgccga ctaaacctct gatgagcccg atgacgctgg acgacatgcg tttgctgtat      360

aaagataacg aagatgtgaa aaacttagac gaactgaccc tgtgcagccg tcacgccggt      420

aatatgaacc cggataatga caaaaacagc aactacaagt atccggcggt ttatgactac      480

aacgacaaaa agtgtcacat tctgtacatc gctgcgcagg aaaacaatgg ccctcgctac      540

tgcaataaag acgagtccaa gcgcaatagc atgttttgtt tccgtccggc caaggacaag      600

agcttccaga actataccta cctgtcgaaa aatgtggttg acaactggga ggaagtttgt      660

ccgcgtaaaa acctggaaaa cgcgaagttc ggcctgtggg ttgatggtaa ctgtgaggac      720

atcccgcacg tcaacgagtt ctcggcaaac gatctgtttg agtgcaacaa actggttttt      780

gaactgagcg cgagcgacca gccgaaacag tatgagcagc acctgacgga ttacgaaaag      840

atcaaggaag gtttcaagaa caagaacgcc tccatgatca agtctgcatt tttgccgact      900

ggcgcgttta aggcggaccg ctacaagtct cgcggtaaag gctacaactg gggcaattac      960

aacaccgaaa cgcagaaatg cgagattttc aacgtaaagc cgacgtgtct gatcaataac     1020

agctcgtaca tcgcgaccac ggcgctgagc catccgaacg aggttgaaaa caattttcct     1080

tgtagcctgt acaaagatga gatcaagaaa gagatcgaac gtgaaagcaa gcgtattaag     1140

ctgaacgata acgacgacga gggcaataag aagattatcg cccctcgtat cttcattagc     1200

gatgacaaag actccctgaa atgcccgtgc gatccggaaa ttgtcagcaa tagcacgtgc     1260

aacttctttg tgtgtaagtg cgtcgagaaa cgtgcggaag ttacctccaa taatgaggtc     1320

gtggtgaagg aagagtataa ggatgagtga                                      1350


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 2 region (from 3D7 sequence)

<400>  20

Pro Arg Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly 
1               5                   10                  15      


Asn Cys Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu 
            20                  25                  30          


Phe Glu Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro 
        35                  40                  45              


Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly 
    50                  55                  60                  


Phe Lys Asn Lys Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr 
65                  70                  75                  80  


Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn 
                85                  90                  95      


Trp Gly Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val 
            100                 105                 110         


Lys Pro Thr Cys 
        115     


<210>  21
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 1 region (from 3D7 sequence)

<400>  21

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Ile Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Asp 
145                 150                 155                 160 


Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys 
    210                 215                 220 


<210>  22
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of M24 AMA1

<400>  22

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Glu Asn Gln Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Lys Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Gln Met Arg Asp Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Glu Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val His Asn Trp Glu Lys Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Thr Lys Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Ile Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Ile Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Arg Phe Tyr Val Cys Lys Cys Val Glu Arg Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  23
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of 102-1 AMA1

<400>  23

Gly Ala Glu Pro Ala Pro Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu 
1               5                   10                  15      


Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met 
            20                  25                  30          


Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg Val Asp 
        35                  40                  45              


Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser 
    50                  55                  60                  


Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn Ser Asn 
65                  70                  75                  80  


Thr Thr Phe Leu Thr Pro Val Ala Thr Glu Asn Lys Asp Leu Lys Asp 
                85                  90                  95      


Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro Met Thr 
            100                 105                 110         


Leu Asp Asp Met Arg Arg Phe Tyr Lys Asp Asn Glu Tyr Val Lys Asn 
        115                 120                 125             


Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met Asn Pro 
    130                 135                 140                 


Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr 
145                 150                 155                 160 


Asn Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn 
                165                 170                 175     


Gly Pro Arg Tyr Cys Asn Lys Asp Gln Ser Lys Arg Asn Ser Met Phe 
            180                 185                 190         


Cys Phe Arg Pro Ala Lys Asp Lys Leu Phe Glu Asn Tyr Thr Tyr Leu 
        195                 200                 205             


Ser Lys Asn Val Val Asp Asn Trp Glu Glu Val Cys Pro Arg Lys Asn 
    210                 215                 220                 


Leu Glu Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys Glu Asp 
225                 230                 235                 240 


Ile Pro His Val Asn Glu Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn 
                245                 250                 255     


Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu 
            260                 265                 270         


Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys 
        275                 280                 285             


Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys 
    290                 295                 300                 


Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr 
305                 310                 315                 320 


Asn Arg Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro Thr Cys 
                325                 330                 335     


Leu Ile Asn Asn Ser Ser Tyr Ile Ala Thr Thr Ala Leu Ser His Pro 
            340                 345                 350         


Asn Glu Val Glu His Asn Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile 
        355                 360                 365             


Lys Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn 
    370                 375                 380                 


Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser 
385                 390                 395                 400 


Asp Asp Ile Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Ile Val Ser 
                405                 410                 415     


Asn Ser Thr Cys Asn Phe Phe Val Cys Lys Cys Val Glu Lys Arg Ala 
            420                 425                 430         


Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr Lys Asp 
        435                 440                 445             


Glu 
    


<210>  24
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of 3D7 AMA-1 protein

<400>  24
ggggcggaac cggcgccgca ggaacagaac ctgtttagca gcattgaaat tgtggaacgt       60

agcaactata tgggcaaccc gtggaccgaa tatatggcga aatatgatat tgaagaagtg      120

catggcagcg gcattcgtgt ggatctgggc gaagatgcgg aagtggcggg cacccagtat      180

cgtctgccga gcggcaaatg cccggtgttt ggcaaaggca ttattattga aaacagcaac      240

accacctttc tgaccccggt ggcgaccggc aaccagtatc tgaaagatgg cggctttgcg      300

tttccgccga ccgaaccgct gatgagcccg atgaccctgg atgaaatgcg tcatttttat      360

aaagataaca aatatgtgaa aaacctggat gaactgaccc tgtgcagccg tcatgcgggc      420

aacatgattc cggataacga taaaaacagc aactataaat atccggcggt gtatgatgat      480

aaagataaaa aatgccatat tctgtatatt gcggcgcagg aaaacaacgg cccgcgttat      540

tgcaacaaag atgaaagcaa acgtaacagc atgttttgct ttcgtccggc gaaagatatt      600

agctttcaga actataccta tctgagcaaa aacgtggtgg ataactggga aaaagtgtgc      660

ccgcgtaaaa acctgcagaa cgcgaaattt ggcctgtggg tggatggcaa ctgcgaagat      720

attccgcatg tgaacgaatt tccggcgatt gatctgtttg aatgcaacaa actggtgttt      780

gaactgagcg cgagcgatca gccgaaacag tatgaacagc atctgaccga ttatgaaaaa      840

attaaagaag gctttaaaaa caaaaacgcg agcatgatta aaagcgcgtt tctgccgacc      900

ggcgcgttta aagcggatcg ttataaaagc cacggcaaag gctataactg gggcaactat      960

aacaccgaaa cccagaaatg cgaaattttt aacgtgaaac cgacctgcct gattaacaac     1020

agcagctata ttgcgaccac cgcgctgagc catccgattg aagtggaaaa caactttccg     1080

tgcagcctgt ataaagatga aattatgaaa gaaattgaac gtgaaagcaa acgtattaaa     1140

ctgaacgata acgatgatga aggcaacaaa aaaattattg cgccgcgtat ttttattagc     1200

gatgataaag atagcctgaa atgcccgtgc gatccggaaa tggtgagcaa cagcacctgc     1260

cgtttttttg tgtgcaaatg cgtggaacgt cgtgcggaag tgaccagcaa caacgaagtg     1320

gtggtgaaag aagaatataa agatgaa                                         1347


<210>  25
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 Heavy Chain DNA Sequence

<400>  25
gaggtgcagc tgcaggagtc tggacctggc ctagtgcggc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattacct ctctatggtg ttcactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtc atatggagtg ggggaagcac agactataat      180

gcagctttcg tctccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

gaaatgaaca gtctgcaagc tgatgacaca gccacatatt actgtgccag aaataatggt      300

tactacgttg atgctatgga ctattggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaacaacac c                                                           371


<210>  26
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 Heavy Chain Protein Sequence

<400>  26

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Met Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Arg Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Ala Val Ser Ser Ala Lys 
        115                 120     


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VH CDR1

<400>  27

Gly Phe Ser Leu Asn Met Tyr Gly 
1               5               


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VH CDR2

<400>  28

Ile Trp Ser Gly Gly Thr Thr 
1               5           


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VH CDR3

<400>  29

Val Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr 
1               5                   10              


<210>  30
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 Light Chain DNA Sequence

<400>  30
gatgttgtga tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gcaacaccta tttacattgg      120

tacctgcaga ggccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcgggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcagagtac acttggtccc      300

acgttcggag gggggaccaa gctggaaatg caacgggctg atg                        343


<210>  31
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 Light Chain Protein Sequence

<400>  31

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr Leu Gly Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Gln Arg 
            100                 105                 110         


Ala Asp 
        


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VL CDR1

<400>  32

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  33
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VL CDR2

<400>  33

Lys Val Ser 
1           


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1B10 VL CDR3

<400>  34

Ser Gln Ser Thr Leu Gly Pro Thr 
1               5               


<210>  35
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 Heavy Chain DNA sequence

<400>  35
gaggtgcagc tgcaggagtc tggacctggc ctagtgcggc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattacct ctctatggtg ttcactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtc atatggagtg ggggaagcac agactataat      180

gcagctttcg tctccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

gaaatgaaca gtctgcaagc tgatgacaca gccacatatt actgtgccag aaataatggt      300

tactacgttg atgctatgga ctattggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaacaacac c                                                           371


<210>  36
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 Heavy Chain Protein Sequence

<400>  36

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Pro Leu Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Glu Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120             


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VH  CDR1

<400>  37

Gly Phe Ser Leu Pro Leu Tyr Gly 
1               5               


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VH  CDR2

<400>  38

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VH  CDR3

<400>  39

Ala Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr 
1               5                   10              


<210>  40
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 Light Chain DNA Sequence

<400>  40
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct tcaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actccagatc      240

agcagagtgg aggctgagga tctgggattt tatttctgct cgcaaagtac acatgttccc      300

acgttcggag gggggaccaa actggaaata aaacgggct                             339


<210>  41
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 Light Chain Protein Sequence

<400>  41

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Phe Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VL CDR1

<400>  42

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  43
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VL CDR2

<400>  43

Lys Val Ser 
1           


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E11 VL CDR3

<400>  44

Ser Gln Ser Thr His Val Pro Thr 
1               5               


<210>  45
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 Heavy Chain DNA Sequence

<400>  45
gaggtgcagc tgcaggagtc tggacctggc ctggtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctgattt ctcattaatt atgtatggtg tacattgggt tcgccagtct      120

ccgggaaagg gtctggagtg gctgggagtg atatggagtg gtggaagcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatatt actgtgccag aaataatggt      300

tactacgttg atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaa                                                                   364


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 Heavy Chain Protein Sequence

<400>  46

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Asp Phe Ser Leu Ile Met Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys 
        115                 120     


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VH CDR1

<400>  47

Asp Phe Ser Leu Ile Met Tyr Gly 
1               5               


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VH CDR2

<400>  48

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VH CDR3

<400>  49

Ala Arg Asn Asn Gly Tyr Tyr Val Asp Ala Met Asp Tyr 
1               5                   10              


<210>  50
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 Light Chain DNA Sequence

<400>  50
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacaataatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tttggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccc      300

acgttcggag gggggaccaa gctggaaatc aaacgtaagt cg                         342


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 Light Chain Protein Sequence

<400>  51

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Lys Ser 
        


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VL CDR1

<400>  52

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VL CDR2

<400>  53

Lys Val Ser 
1           


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 4E8 VL CDR3

<400>  54

Ser Gln Ser Thr His Val Pro Thr 
1               5               


<210>  55
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 Heavy Chain DNA sequence

<400>  55
gaggtgcagc tgcaggagtc tggggctgaa ttggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact aactacttga tgcactggat aaaacaaagg      120

cctggacggt ctggaatgga ttggatacat taatcatggc agtggttata ctaactacaa      180

tcagaagttc attgacaggg ccacattgac tgcagacaaa tcctccagca cagcctacat      240

gcagctgcgc agctacatat gaggactctg cagtctatta ctgtgtccac gggtacttcg      300

atgtctgggg cacagggacc acggtcaccg tctcctcagc caaaacgaca cccccatctg      360

tctatccact ggccc                                                       375


<210>  56
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 Heavy Chain Protein Sequence

<400>  56

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn His Gly Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Ile Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val His Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125     


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VH CDR1

<400>  57

Gly Tyr Thr Phe Thr Asn Tyr Leu 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VH CDR2

<400>  58

Ile Asn His Gly Ser Gly Tyr Thr 
1               5               


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VH CDR3

<400>  59

Val His Gly Tyr Phe Asp Val 
1               5           


<210>  60
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 Light Chain DNA sequence

<400>  60
caagtgcaga ttttcagctt cctgctaatc agtgcctcag tcatactgtc cagaggacaa       60

attgttctca cccagtctcc aacaatcatg tctgcatctc caggggagaa ggtcaccatg      120

acctgcagtg ccagctcaag tgtaacttac atgcactggt accagcagaa gccaggcacc      180

tcccccaaaa gatggattta tgacacatcc aaactggcct ctggagtccc tgctcgcttc      240

agtggcagtg ggtctgggac ctcttattct ctcacaatca gcagcatgga ggctgaagat      300

gctgccactt attactgcca tcagcggagt agttacccca cgttcggagg ggggaccaag      360

ctggaaatca aacgtaagtc gactgcacca                                       390


<210>  61
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 Light Chain Protein sequence

<400>  61

Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Leu 
1               5                   10                  15      


Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr 
            100                 105                 110         


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Lys Ser Thr 
        115                 120                 125             


Ala Pro 
    130 


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VL CDR1

<400>  62

Ser Ser Ser Val Thr Tyr 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VL CDR2

<400>  63

Asp Thr Ser 
1           


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal 1E10 VL CDR3

<400>  64

His Gln Arg Ser Ser Tyr Pro Thr 
1               5               


