                         SEQUENCE LISTING

<110>  PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120>  METHODS AND COMPOSITIONS FOR REJUVENATING SKELETAL MUSCLE STEM 
       CELLS

<130>  HRVY-022-WO2

<140>  PCT/US2014/064648
<141>  2014-11-07

<150>  US 61/901,875
<151>  2013-11-08

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg 
        275                 280                 285             


Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp 
    290                 295                 300                 


Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln 
305                 310                 315                 320 


Cys Glu Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln 
                325                 330                 335     


Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys 
            340                 345                 350         


Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile 
        355                 360                 365             


Tyr Gly Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380             


<210>  3
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  4
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg 
        


