                         SEQUENCE LISTING

<110>  The United States of America, as Represented by the 
       Secretary, Department of Health and human Services
       MacKall, Crystal
       Orentas, Rimas
 
<120>  ALK ANTIBODIES, CONJUGATES, AND CHIMERIC ANTIGEN RECEPTORS, AND 
       THEIR USE

<130>  4239-92075-02

<150>  61/900,806
<151>  2013-11-06

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  1

Asp Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Gly Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu His Tyr Tyr Gly Ser Ser Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Ile Thr Val Ser Ser 
        115                 


<210>  2
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  2

Gly Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Thr Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  4

Asp Val Gln Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Lys Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  5

Asp Val Gln Leu Gln Glu Ser Gly Pro Val Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Phe Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asn Trp Gly Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  6
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  6

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Arg Leu Ile Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  7

Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Pro Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  8

Asp Val Gln Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn 
            100                 105         


<210>  9
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val 
        115                 


<210>  10
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His 
                85                  90                  95      


Val Pro Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  11
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val 
        115                 


<210>  12
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp 
                85                  90                  95      


Pro Pro Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  13
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Phe Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asn Trp Gly Ala Tyr Phe Asp Tyr Trp Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val 
        115         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu 
                85                  90                  95      


Asp Pro Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  15
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser Phe Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val 
        115                 


<210>  16
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody variable domain sequence

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  17
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  17

Asp Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Gly Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu His Tyr Tyr Gly Ser Ser Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Ile Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Ile Val Met Thr Gln Ser Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Ser Ile Val His Ser Tyr Gly Asn Thr Tyr Leu Phe Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn 
            180                 185                 190         


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asn Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Met Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Phe Gln Gly Thr His Val Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  18
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Thr Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met Ile Gln Thr Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn 
            180                 185                 190         


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  19
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  19

Asp Val Gln Leu Gln Glu Ser Gly Pro Val Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Phe Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asn Trp Gly Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
    130                 135                 140                 


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
145                 150                 155                 160 


Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
                165                 170                 175     


Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile Tyr Tyr Met Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  20
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  20

Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Pro Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met Ile Gln Thr Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Asn 
        


<210>  21
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr Tyr Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Val Ser 
            180                 185                 190         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Phe Gln Gly Thr His Val Pro Tyr Thr Phe Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Arg 
                245             


<210>  22
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro Thr Phe Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg 
                245         


<210>  23
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Phe Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asn Trp Gly Ala Tyr Phe Asp Tyr Trp Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Met Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr Phe Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Arg 
                245     


<210>  24
<211>  243
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv sequence

<400>  24

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser Phe Asp Tyr Trp Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr Ser Arg Ala Thr Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  22
<212>  PRT
<213>  homo sapiens

<400>  26

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr 
            20          


<210>  27
<211>  67
<212>  PRT
<213>  homo sapiens

<400>  27

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg 
65          


<210>  28
<211>  40
<212>  PRT
<213>  homo sapiens

<400>  28

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  29
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  29

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  30
<211>  69
<212>  PRT
<213>  homo sapiens

<400>  30

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  31
<211>  84
<212>  PRT
<213>  homo sapiens

<400>  31

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  32
<211>  42
<212>  PRT
<213>  homo sapiens

<400>  32

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  33
<211>  47
<212>  PRT
<213>  homo sapiens

<400>  33

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  34
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  34

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  35
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  35

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210>  36
<211>  708
<212>  DNA
<213>  homo sapiens

<400>  36
gaacccaagt catgcgataa gacccacact tgtccaccct gtccagcccc tgaactgctc       60

ggaggtccgt cagtgtttct tttcccgcca aagcctaagg acactctgat gatctctcgg      120

acccctgaag tgacttgcgt cgtcgtggac gtgtcacacg aggatcccga ggtgaagttc      180

aactggtatg tggacggggt ggaagtgcat aatgctaaga ccaagcccag ggaggaacaa      240

tacaactcaa cctaccgcgt ggtgtccgtg ctcaccgtcc ttcatcaaga ctggctgaac      300

ggaaaagagt ataagtgcaa agtctccaat aaggctctgc cagcccctat cgaaaagacc      360

atttcaaagg ccaaggggca gcctagagag ccccaagtgt acacccttcc tccctcaaga      420

gatgagctca ctaagaatca ggtcagcctg acttgtcttg tgaaaggctt ctatcccagc      480

gatattgccg tcgaatggga aagcaatgga caaccagaga acaactacaa gaccaccccg      540

cctgtgctgg actccgacgg ctctttcttc ctttactcaa agctgaccgt cgataagagc      600

cggtggcaac aggggaatgt gttcagctgc tccgtcatgc acgaggctct ccataaccac      660

tacacccaga aaagcctgtc tctttctccg ggcaaaaagg acccaaag                   708


<210>  37
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  37

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210>  38
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  38
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggg ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      300

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc      360

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      420

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      480

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      540

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac      600

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      660

cctcgctaa                                                              669


<210>  39
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  39

Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
65                  70                  75                  80  


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                85                  90                  95      


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            100                 105                 110         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        115                 120                 125             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    130                 135                 140                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
145                 150                 155                 160 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                165                 170                 175     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            180                 185                 190         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        195                 200                 205             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    210                 215                 220                 


Pro Arg 
225     


<210>  40
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  40
gcggccgcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg       60

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      120

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      180

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg      240

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      300

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg      360

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta      420

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      480

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      540

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac      600

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg      660

caggccctgc cccctcgcta a                                                681


<210>  41
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  41

Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  


Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                85                  90                  95      


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            100                 105                 110         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
        115                 120                 125             


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    130                 135                 140                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
145                 150                 155                 160 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                165                 170                 175     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            180                 185                 190         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    210                 215                 220                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
225                 230                 235                 240 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                245                 250                 255     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            260                 265                 270         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 285     


<210>  42
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR TM and instracellular sequence

<400>  42
gcggccgcat tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga       60

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      120

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      180

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt      240

tactgcaacc acaggaacag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      300

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc      360

gacttcgcag cctatcgctc ccgtttctct gttgttaaac ggggcagaaa gaagctcctg      420

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      480

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg      540

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta      600

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      660

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      720

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac      780

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg      840

caggccctgc cccctcgcta a                                                861


<210>  43
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  43

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val Met Tyr 
            500                 505                 510         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        515                 520                 525             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    530                 535                 540                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
545                 550                 555                 560 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                565                 570                 575     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            580                 585                 590         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        595                 600                 605             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    610                 615                 620                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
625                 630                 635                 640 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                645                 650                 655     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            660                 665                 670         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        675                 680                 685             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    690                 695                 700                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
705                 710                 715                 720 


Gln Ala Leu Pro Pro Arg 
                725     


<210>  44
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  44

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Ile 
            260                 265                 270         


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  45
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  45

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr Pro Ala 
            500                 505                 510         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        515                 520                 525             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    530                 535                 540                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
545                 550                 555                 560 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                565                 570                 575     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            580                 585                 590         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        595                 600                 605             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    610                 615                 620                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
625                 630                 635                 640 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                645                 650                 655     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            660                 665                 670         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        675                 680                 685             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    690                 695                 700                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
705                 710                 715                 720 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730 


<210>  46
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  46

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  47
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  47

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro Val Phe 
            500                 505                 510         


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        515                 520                 525             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    530                 535                 540                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
545                 550                 555                 560 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                565                 570                 575     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser 
            580                 585                 590         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        595                 600                 605             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    610                 615                 620                 


Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg 
625                 630                 635                 640 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                645                 650                 655     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            660                 665                 670         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        675                 680                 685             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    690                 695                 700                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
705                 710                 715                 720 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                725                 730                 735     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            740                 745                 750         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        755                 760                 765             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    770                 775                 780                 


Gln Ala Leu Pro Pro Arg 
785                 790 


<210>  48
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  48

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Lys Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Ile Ile Trp Ser Gly Gly Ala Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Met Asn Gly Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Arg Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ala Ser Ile Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Tyr Gly Asn Thr 
            180                 185                 190         


Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        435                 440                 445             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    450                 455                 460                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
465                 470                 475                 480 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                485                 490                 495     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            500                 505                 510         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        515                 520                 525             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    530                 535                 540                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 


<210>  49
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  49

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val 
            500                 505                 510         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        515                 520                 525             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    530                 535                 540                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
545                 550                 555                 560 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                565                 570                 575     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            580                 585                 590         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        595                 600                 605             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  50
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  50

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  51
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  51

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  52
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  52

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  53
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  53

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro 
            500                 505                 510         


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            580                 585                 590         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        595                 600                 605             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    610                 615                 620                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg 
625                 630                 635                 640 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                645                 650                 655     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            660                 665                 670         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        675                 680                 685             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    690                 695                 700                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
705                 710                 715                 720 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                725                 730                 735     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            740                 745                 750         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        755                 760                 765             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    770                 775                 780                 


His Met Gln Ala Leu Pro Pro Arg 
785                 790         


<210>  54
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  54

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Thr Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
            180                 185                 190         


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
            340                 345                 350         


His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        355                 360                 365             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    370                 375                 380                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val 
385                 390                 395                 400 


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                405                 410                 415     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            420                 425                 430         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
        435                 440                 445             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
465                 470                 475                 480 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                485                 490                 495     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            500                 505                 510         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        515                 520                 525             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    530                 535                 540                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 555 


<210>  55
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  55

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val Met Tyr Pro 
            500                 505                 510         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        515                 520                 525             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    530                 535                 540                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
545                 550                 555                 560 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                565                 570                 575     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            580                 585                 590         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        595                 600                 605             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    610                 615                 620                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
625                 630                 635                 640 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                645                 650                 655     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            660                 665                 670         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        675                 680                 685             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
705                 710                 715                 720 


Ala Leu Pro Pro Arg 
                725 


<210>  56
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  56

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  57
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  57

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            500                 505                 510         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        515                 520                 525             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    530                 535                 540                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
545                 550                 555                 560 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                565                 570                 575     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            580                 585                 590         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        595                 600                 605             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    610                 615                 620                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
625                 630                 635                 640 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                645                 650                 655     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            660                 665                 670         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        675                 680                 685             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    690                 695                 700                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
705                 710                 715                 720 


Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 


<210>  58
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  58

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  59
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  59

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro Val Phe Leu 
            500                 505                 510         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        515                 520                 525             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    530                 535                 540                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
545                 550                 555                 560 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                565                 570                 575     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys 
            580                 585                 590         


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
        595                 600                 605             


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
    610                 615                 620                 


Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
625                 630                 635                 640 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                645                 650                 655     


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            660                 665                 670         


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        675                 680                 685             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    690                 695                 700                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
705                 710                 715                 720 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                725                 730                 735     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            740                 745                 750         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        755                 760                 765             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    770                 775                 780                 


Ala Leu Pro Pro Arg 
785                 


<210>  60
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  60

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Asp Val Gln Leu Gln Glu Ser Gly Pro Val 
            20                  25                  30          


Leu Val Lys Thr Gly Ala Ser Val Lys Met Ser Cys Thr Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Met Asp Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Ser Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Val Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        355                 360                 365             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    370                 375                 380                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys 
385                 390                 395                 400 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                405                 410                 415     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            420                 425                 430         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        435                 440                 445             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    450                 455                 460                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
465                 470                 475                 480 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                485                 490                 495     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            500                 505                 510         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        515                 520                 525             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    530                 535                 540                 


Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550             


<210>  61
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  61

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val Met Tyr Pro Pro 
            500                 505                 510         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        515                 520                 525             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    530                 535                 540                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
545                 550                 555                 560 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                565                 570                 575     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            580                 585                 590         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        595                 600                 605             


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    610                 615                 620                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
625                 630                 635                 640 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                645                 650                 655     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            660                 665                 670         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        675                 680                 685             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    690                 695                 700                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
705                 710                 715                 720 


Leu Pro Pro Arg 
                


<210>  62
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  62

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Ala Ala Ile Glu Val Met 
            260                 265                 270         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        275                 280                 285             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    290                 295                 300                 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  63
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  63

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
            500                 505                 510         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        515                 520                 525             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    530                 535                 540                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
545                 550                 555                 560 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                565                 570                 575     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            580                 585                 590         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        595                 600                 605             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  64
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  64

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  65
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  65

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro Val Phe Leu Pro 
            500                 505                 510         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        515                 520                 525             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    530                 535                 540                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
545                 550                 555                 560 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                565                 570                 575     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg 
            580                 585                 590         


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        595                 600                 605             


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    610                 615                 620                 


Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
625                 630                 635                 640 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                645                 650                 655     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            660                 665                 670         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        675                 680                 685             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    690                 695                 700                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
705                 710                 715                 720 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                725                 730                 735     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            740                 745                 750         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        755                 760                 765             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    770                 775                 780                 


Leu Pro Pro Arg 
785             


<210>  66
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  66

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Ala Leu Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val 
    50                  55                  60                  


His Gly Leu Glu Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Glu Gly Lys Ala Ile Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Pro Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Met Ile Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Asn Arg Ala Ala Ala Phe Val Pro Val 
            260                 265                 270         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        275                 280                 285             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    290                 295                 300                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
305                 310                 315                 320 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                325                 330                 335     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly 
385                 390                 395                 400 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                405                 410                 415     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            420                 425                 430         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg 
545                 550     


<210>  67
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  67

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val 
            500                 505                 510         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        515                 520                 525             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    530                 535                 540                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
545                 550                 555                 560 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                565                 570                 575     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            580                 585                 590         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        595                 600                 605             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  68
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  68

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        275                 280                 285             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    290                 295                 300                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  69
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  69

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  70
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  70

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  71
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  71

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro 
            500                 505                 510         


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            580                 585                 590         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        595                 600                 605             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    610                 615                 620                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg 
625                 630                 635                 640 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                645                 650                 655     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            660                 665                 670         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        675                 680                 685             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    690                 695                 700                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
705                 710                 715                 720 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                725                 730                 735     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            740                 745                 750         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        755                 760                 765             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    770                 775                 780                 


His Met Gln Ala Leu Pro Pro Arg 
785                 790         


<210>  72
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  72

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Trp Ser Gly Gly Ala Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Tyr Tyr Gly Ser Ser Ala 
        115                 120                 125             


Met Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Val His Ser Tyr Gly 
            180                 185                 190         


Asn Thr Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Arg Val Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Thr His Val Pro 
                245                 250                 255     


Tyr Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    370                 375                 380                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser 
385                 390                 395                 400 


Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                405                 410                 415     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            420                 425                 430         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
        435                 440                 445             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
465                 470                 475                 480 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                485                 490                 495     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            500                 505                 510         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        515                 520                 525             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    530                 535                 540                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 555     


<210>  73
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  73

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val 
            500                 505                 510         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        515                 520                 525             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    530                 535                 540                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
545                 550                 555                 560 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                565                 570                 575     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            580                 585                 590         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        595                 600                 605             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  74
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  74

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        275                 280                 285             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    290                 295                 300                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  75
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  75

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  76
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  76

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  77
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  77

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro 
            500                 505                 510         


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            580                 585                 590         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        595                 600                 605             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    610                 615                 620                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg 
625                 630                 635                 640 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                645                 650                 655     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            660                 665                 670         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        675                 680                 685             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    690                 695                 700                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
705                 710                 715                 720 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                725                 730                 735     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            740                 745                 750         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        755                 760                 765             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    770                 775                 780                 


His Met Gln Ala Leu Pro Pro Arg 
785                 790         


<210>  78
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  78

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ala Phe Ser Ser Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Tyr Tyr Tyr Gly Ser Ser Gly Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile 
            180                 185                 190         


Ser Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Lys Asp Pro Pro 
                245                 250                 255     


Thr Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
            340                 345                 350         


His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        355                 360                 365             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    370                 375                 380                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val 
385                 390                 395                 400 


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                405                 410                 415     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            420                 425                 430         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
        435                 440                 445             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
465                 470                 475                 480 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                485                 490                 495     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            500                 505                 510         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        515                 520                 525             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    530                 535                 540                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 555 


<210>  79
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  79

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val Met Tyr 
            500                 505                 510         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        515                 520                 525             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    530                 535                 540                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
545                 550                 555                 560 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                565                 570                 575     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            580                 585                 590         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        595                 600                 605             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    610                 615                 620                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
625                 630                 635                 640 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                645                 650                 655     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            660                 665                 670         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        675                 680                 685             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    690                 695                 700                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
705                 710                 715                 720 


Gln Ala Leu Pro Pro Arg 
                725     


<210>  80
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  80

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile 
            260                 265                 270         


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  81
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  81

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr Pro Ala 
            500                 505                 510         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        515                 520                 525             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    530                 535                 540                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
545                 550                 555                 560 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                565                 570                 575     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            580                 585                 590         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        595                 600                 605             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    610                 615                 620                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
625                 630                 635                 640 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                645                 650                 655     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            660                 665                 670         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        675                 680                 685             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    690                 695                 700                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
705                 710                 715                 720 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730 


<210>  82
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  82

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  83
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  83

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Pro Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro Val Phe 
            500                 505                 510         


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        515                 520                 525             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    530                 535                 540                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
545                 550                 555                 560 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                565                 570                 575     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser 
            580                 585                 590         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        595                 600                 605             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    610                 615                 620                 


Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg 
625                 630                 635                 640 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                645                 650                 655     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            660                 665                 670         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        675                 680                 685             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    690                 695                 700                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
705                 710                 715                 720 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                725                 730                 735     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            740                 745                 750         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        755                 760                 765             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    770                 775                 780                 


Gln Ala Leu Pro Pro Arg 
785                 790 


<210>  84
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  84

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp His Phe Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Leu Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Asn Trp Gly Ala Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Tyr Met Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Met Gln Gly Leu Glu Asp Pro Tyr Thr 
                245                 250                 255     


Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        435                 440                 445             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    450                 455                 460                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
465                 470                 475                 480 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                485                 490                 495     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            500                 505                 510         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        515                 520                 525             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    530                 535                 540                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 


<210>  85
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  85

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Ile Glu Val Met Tyr Pro Pro 
            500                 505                 510         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        515                 520                 525             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    530                 535                 540                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
545                 550                 555                 560 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                565                 570                 575     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            580                 585                 590         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        595                 600                 605             


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    610                 615                 620                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
625                 630                 635                 640 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                645                 650                 655     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            660                 665                 670         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        675                 680                 685             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    690                 695                 700                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
705                 710                 715                 720 


Leu Pro Pro Arg 
                


<210>  86
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  86

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met 
            260                 265                 270         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        275                 280                 285             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    290                 295                 300                 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  87
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  87

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
            500                 505                 510         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        515                 520                 525             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    530                 535                 540                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
545                 550                 555                 560 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                565                 570                 575     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            580                 585                 590         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        595                 600                 605             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  88
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  88

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  89
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  89

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Ala Ala Ala Phe Val Pro Val Phe Leu Pro 
            500                 505                 510         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        515                 520                 525             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    530                 535                 540                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
545                 550                 555                 560 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                565                 570                 575     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg 
            580                 585                 590         


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        595                 600                 605             


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    610                 615                 620                 


Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
625                 630                 635                 640 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                645                 650                 655     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            660                 665                 670         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        675                 680                 685             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    690                 695                 700                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
705                 710                 715                 720 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                725                 730                 735     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            740                 745                 750         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        755                 760                 765             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    770                 775                 780                 


Leu Pro Pro Arg 
785             


<210>  90
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  90

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Tyr Tyr Gly Ser Ser Ser 
        115                 120                 125             


Phe Asp Tyr Trp Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Pro Thr Phe Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Phe Val Pro Val 
            260                 265                 270         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        275                 280                 285             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    290                 295                 300                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
305                 310                 315                 320 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                325                 330                 335     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg Gly 
385                 390                 395                 400 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                405                 410                 415     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            420                 425                 430         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg 
545                 550     


<210>  91
<211>  2203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  91
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgaagctg caggaatctg gccctggact      120

ggtggcccct agccagagcc tgagcatcac ctgtaccgtg tccggcttca gcctgaccag      180

ctacgccgtg tcttgggtgc gccagcctcc tggcaaaggc ctggaatggc tgggcatcat      240

ttggagcggc ggagccacca actacaacag cgccctgaag tcccggctga gcatctccaa      300

ggacaacagc aagagccagg tgttcctgaa gatgaacggc ctgcagaccg acgacaccgc      360

ccggtactat tgcgccagag agcactacta cggcagcagc gctatggact actggggcca      420

gggcgccagc atcacagtgt ctagcggagg cggaggatct ggcggcggag gaagtggcgg      480

agggggatct ggaatcgtga tgacccagag ccctctgagc ctgcctgtgt ccctgggaga      540

tcaggcctcc atcagctgca gatccagcca gagcatcgtg cacagctacg gcaacaccta      600

cctgttctgg tatctgcaga agcccggcca gagccccaag ctgctgatct accgggtgtc      660

caaccggttc agcggcgtgc ccgatagatt ttccggcagc ggctccggca ccaacttcac      720

cctgaagatc agccgggtgg aagccgagga catgggcgtg tactactgtt ttcaaggcac      780

ccacgtgccc tacaccttcg gaggcggcac caagctggaa atcaaagagc ccaagagctg      840

cgacaagacc cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gacctagcgt      900

gttcctgttc cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac      960

ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg aagttcaatt ggtacgtgga     1020

cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta     1080

cagagtggtg tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa     1140

gtgcaaagtg tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa     1200

gggccagccc cgcgaacccc aggtgtacac actgccccct agcagggacg agctgaccaa     1260

gaatcaggtg tccctgacct gtctcgtgaa gggcttctac ccctccgata tcgccgtgga     1320

atgggagagc aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag     1380

cgacggctca ttcttcctgt acagcaagct gacagtggac aagagccggt ggcagcaggg     1440

caacgtgttc agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc     1500

cctgtccctg agccccggca agaaggaccc caaagcggcc gcaattgaag ttatgtatcc     1560

tcctccttac ctagacaatg agaagagcaa tggaaccatt atccatgtga aagggaaaca     1620

cctttgtcca agtcccctat ttcccggacc ttctaagccc ttttgggtgc tggtggtggt     1680

tgggggagtc ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt     1740

gaggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc     1800

cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg     1860

ctccagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca     1920

gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg     1980

tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta     2040

caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga     2100

gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga     2160

cacctacgac gcccttcaca tgcaggccct gccccctcgc taa                       2203


<210>  92
<211>  1495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  92
ccctcgagcc gccaccatgg ttctcctcgt gacttccctt ctgctgtgcg agctcccaca       60

ccccgccttc ctgctcattc ctgataccga tgtgaagctg caagaatccg gccccggact      120

ggtcgcgcca agccaatcgc tgagcattac ttgcacggtg tccggatttt cgttgacctc      180

ctacgctgtg tcctgggtca gacagccgcc gggtaaagga ctcgaatggc ttggcatcat      240

ctggtcgggc ggagcgacta actacaactc agcgctgaaa tcgcggctgt ccatctcaaa      300

ggataattca aaaagccagg tgtttctgaa gatgaatggc ctgcagactg acgacaccgc      360

tcgctactac tgcgcccgcg agcattacta cggatcatcc gcaatggact attgggggca      420

gggcgcatct atcaccgtca gcagcggggg cggaggttct ggcggagggg gttcgggcgg      480

gggagggagc ggaatcgtga tgacccagtc gccgctttcc ttgcctgtca gcctgggaga      540

tcaggccagc atctcatgtc ggtcgtccca gagcatcgtg cactcgtacg gtaacacgta      600

cctcttctgg tacctccaaa agcctggaca gtcaccaaag ctgttgatct atagggtgtc      660

caatcgcttc tcgggtgtgc cggaccggtt ctcgggctcg ggatcaggaa ccaactttac      720

tctgaagatc tccagagtgg aagccgagga catgggagtc tactactgct tccaaggaac      780

tcatgttccg tacaccttcg gaggagggac caagctggaa atcaaggcgg ccgcaattga      840

agttatgtat cctcctcctt acctagacaa tgagaagagc aatggaacca ttatccatgt      900

gaaagggaaa cacctttgtc caagtcccct atttcccgga ccttctaagc ccttttgggt      960

gctggtggtg gttgggggag tcctggcttg ctatagcttg ctagtaacag tggcctttat     1020

tattttctgg gtgaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac     1080

tccccgccgc cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt     1140

cgcagcctat cgctccagag tgaagttcag caggagcgca gacgcccccg cgtaccagca     1200

gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt     1260

ggacaagaga cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca     1320

ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg     1380

gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac     1440

agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa          1495


<210>  93
<211>  2215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  93
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgaagctg caggaatctg gccctggact      120

ggtggcccct agccagagcc tgagcatcac ctgtaccgtg tccggcttca gcctgaccag      180

ctacgccgtg tcttgggtgc gccagcctcc tggcaaaggc ctggaatggc tgggcatcat      240

ttggagcggc ggagccacca actacaacag cgccctgaag tcccggctga gcatctccaa      300

ggacaacagc aagagccagg tgttcctgaa gatgaacggc ctgcagaccg acgacaccgc      360

ccggtactat tgcgccagag agcactacta cggcagcagc gctatggact actggggcca      420

gggcgccagc atcacagtgt ctagcggagg cggaggatct ggcggcggag gaagtggcgg      480

agggggatct ggaatcgtga tgacccagag ccctctgagc ctgcctgtgt ccctgggaga      540

tcaggcctcc atcagctgca gatccagcca gagcatcgtg cacagctacg gcaacaccta      600

cctgttctgg tatctgcaga agcccggcca gagccccaag ctgctgatct accgggtgtc      660

caaccggttc agcggcgtgc ccgatagatt ttccggcagc ggctccggca ccaacttcac      720

cctgaagatc agccgggtgg aagccgagga catgggcgtg tactactgtt ttcaaggcac      780

ccacgtgccc tacaccttcg gaggcggcac caagctggaa atcaaagagc ccaagagctg      840

cgacaagacc cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gacctagcgt      900

gttcctgttc cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac      960

ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg aagttcaatt ggtacgtgga     1020

cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta     1080

cagagtggtg tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa     1140

gtgcaaagtg tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa     1200

gggccagccc cgcgaacccc aggtgtacac actgccccct agcagggacg agctgaccaa     1260

gaatcaggtg tccctgacct gtctcgtgaa gggcttctac ccctccgata tcgccgtgga     1320

atgggagagc aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag     1380

cgacggctca ttcttcctgt acagcaagct gacagtggac aagagccggt ggcagcaggg     1440

caacgtgttc agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc     1500

cctgtccctg agccccggca agaaggaccc caaagcggcc gcaaccacga cgccagcgcc     1560

gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc     1620

gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat     1680

ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac     1740

cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag     1800

accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga     1860

aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca     1920

gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt     1980

ggacaagaga cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca     2040

ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg     2100

gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac     2160

agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa          2215


<210>  94
<211>  1507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  94
ccctcgagcc gccaccatgg ttctcctcgt gacttccctt ctgctgtgcg agctcccaca       60

ccccgccttc ctgctcattc ctgataccga tgtgaagctg caagaatccg gccccggact      120

ggtcgcgcca agccaatcgc tgagcattac ttgcacggtg tccggatttt cgttgacctc      180

ctacgctgtg tcctgggtca gacagccgcc gggtaaagga ctcgaatggc ttggcatcat      240

ctggtcgggc ggagcgacta actacaactc agcgctgaaa tcgcggctgt ccatctcaaa      300

ggataattca aaaagccagg tgtttctgaa gatgaatggc ctgcagactg acgacaccgc      360

tcgctactac tgcgcccgcg agcattacta cggatcatcc gcaatggact attgggggca      420

gggcgcatct atcaccgtca gcagcggggg cggaggttct ggcggagggg gttcgggcgg      480

gggagggagc ggaatcgtga tgacccagtc gccgctttcc ttgcctgtca gcctgggaga      540

tcaggccagc atctcatgtc ggtcgtccca gagcatcgtg cactcgtacg gtaacacgta      600

cctcttctgg tacctccaaa agcctggaca gtcaccaaag ctgttgatct atagggtgtc      660

caatcgcttc tcgggtgtgc cggaccggtt ctcgggctcg ggatcaggaa ccaactttac      720

tctgaagatc tccagagtgg aagccgagga catgggagtc tactactgct tccaaggaac      780

tcatgttccg tacaccttcg gaggagggac caagctggaa atcaaggcgg ccgcaaccac      840

gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct      900

gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt      960

cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc     1020

actggttatc accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca     1080

accatttatg agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc     1140

agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc     1200

cgcgtacaag cagggccaga accagctcta taacgagctc aatctaggac gaagagagga     1260

gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag     1320

gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta     1380

cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca     1440

gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc     1500

tcgctaa                                                               1507


<210>  95
<211>  2395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  95
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgaagctg caggaatctg gccctggact      120

ggtggcccct agccagagcc tgagcatcac ctgtaccgtg tccggcttca gcctgaccag      180

ctacgccgtg tcttgggtgc gccagcctcc tggcaaaggc ctggaatggc tgggcatcat      240

ttggagcggc ggagccacca actacaacag cgccctgaag tcccggctga gcatctccaa      300

ggacaacagc aagagccagg tgttcctgaa gatgaacggc ctgcagaccg acgacaccgc      360

ccggtactat tgcgccagag agcactacta cggcagcagc gctatggact actggggcca      420

gggcgccagc atcacagtgt ctagcggagg cggaggatct ggcggcggag gaagtggcgg      480

agggggatct ggaatcgtga tgacccagag ccctctgagc ctgcctgtgt ccctgggaga      540

tcaggcctcc atcagctgca gatccagcca gagcatcgtg cacagctacg gcaacaccta      600

cctgttctgg tatctgcaga agcccggcca gagccccaag ctgctgatct accgggtgtc      660

caaccggttc agcggcgtgc ccgatagatt ttccggcagc ggctccggca ccaacttcac      720

cctgaagatc agccgggtgg aagccgagga catgggcgtg tactactgtt ttcaaggcac      780

ccacgtgccc tacaccttcg gaggcggcac caagctggaa atcaaagagc ccaagagctg      840

cgacaagacc cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gacctagcgt      900

gttcctgttc cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac      960

ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg aagttcaatt ggtacgtgga     1020

cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta     1080

cagagtggtg tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa     1140

gtgcaaagtg tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa     1200

gggccagccc cgcgaacccc aggtgtacac actgccccct agcagggacg agctgaccaa     1260

gaatcaggtg tccctgacct gtctcgtgaa gggcttctac ccctccgata tcgccgtgga     1320

atgggagagc aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag     1380

cgacggctca ttcttcctgt acagcaagct gacagtggac aagagccggt ggcagcaggg     1440

caacgtgttc agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc     1500

cctgtccctg agccccggca agaaggaccc caaagcggcc gcattcgtgc cggtcttcct     1560

gccagcgaag cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc     1620

gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca     1680

cacgaggggg ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg     1740

tggggtcctt ctcctgtcac tggttatcac cctttactgc aaccacagga acaggagtaa     1800

gaggagcagg ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac     1860

ccgcaagcat taccagccct atgccccacc acgcgacttc gcagcctatc gctcccgttt     1920

ctctgttgtt aaacggggca gaaagaagct cctgtatata ttcaaacaac catttatgag     1980

accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga     2040

aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca     2100

gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt     2160

ggacaagaga cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca     2220

ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg     2280

gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac     2340

agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa          2395


<210>  96
<211>  1687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  96
ccctcgagcc gccaccatgg ttctcctcgt gacttccctt ctgctgtgcg agctcccaca       60

ccccgccttc ctgctcattc ctgataccga tgtgaagctg caagaatccg gccccggact      120

ggtcgcgcca agccaatcgc tgagcattac ttgcacggtg tccggatttt cgttgacctc      180

ctacgctgtg tcctgggtca gacagccgcc gggtaaagga ctcgaatggc ttggcatcat      240

ctggtcgggc ggagcgacta actacaactc agcgctgaaa tcgcggctgt ccatctcaaa      300

ggataattca aaaagccagg tgtttctgaa gatgaatggc ctgcagactg acgacaccgc      360

tcgctactac tgcgcccgcg agcattacta cggatcatcc gcaatggact attgggggca      420

gggcgcatct atcaccgtca gcagcggggg cggaggttct ggcggagggg gttcgggcgg      480

gggagggagc ggaatcgtga tgacccagtc gccgctttcc ttgcctgtca gcctgggaga      540

tcaggccagc atctcatgtc ggtcgtccca gagcatcgtg cactcgtacg gtaacacgta      600

cctcttctgg tacctccaaa agcctggaca gtcaccaaag ctgttgatct atagggtgtc      660

caatcgcttc tcgggtgtgc cggaccggtt ctcgggctcg ggatcaggaa ccaactttac      720

tctgaagatc tccagagtgg aagccgagga catgggagtc tactactgct tccaaggaac      780

tcatgttccg tacaccttcg gaggagggac caagctggaa atcaaggcgg ccgcattcgt      840

gccggtcttc ctgccagcga agcccaccac gacgccagcg ccgcgaccac caacaccggc      900

gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg      960

gggcgcagtg cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt     1020

ggccgggact tgtggggtcc ttctcctgtc actggttatc accctttact gcaaccacag     1080

gaacaggagt aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg     1140

ccccgggccc acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta     1200

tcgctcccgt ttctctgttg ttaaacgggg cagaaagaag ctcctgtata tattcaaaca     1260

accatttatg agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc     1320

agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc     1380

cgcgtaccag cagggccaga accagctcta taacgagctc aatctaggac gaagagagga     1440

gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag     1500

gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta     1560

cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca     1620

gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc     1680

tcgctaa                                                               1687


<210>  97
<211>  2209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  97
ccctcgagcc gccaccatgg ttcttctcgt gacaagcctt cttctctgcg aattgcccca       60

cccagccttt ttgcttatcc ccgacaccca agtccagctg cagcaatcag gggccgagtt      120

ggtcaagcct ggggcatcgg tcaaaatctc atgtaaagcc tcgggatatg cgttctcgtc      180

atactggatg aattgggtca agcagcggcc aggaaaggga ctggaatgga tcgggcaaat      240

ctacccaggg gatggagata caacatataa cgggaagttt aaagggaaag caactctcac      300

tgcggacaag tcatcatcga cggtatacat gcagcttaac tcattgacaa gcgaggactc      360

ggcggtctat ttctgcgtac ggtattacta cggatcgtcg gggtacttcg attattgggg      420

tcagggaacc acgctgacag tgtccagcgg aggtggcggg tccggaggcg gaggatccgg      480

tggcggtgga agcgatgtgc agatgatcca gacgccggac tcactcgcgg tgtcactcgg      540

gcagcgggcg acgatttcat gcagagcctc cgagtcggtg gacaattacg gtatctcctt      600

catgcattgg tatcagcaga aacccgggca gtcgcccaag ctgttgatct acagagcgtc      660

caaccttgag tcggggattc ccgctaggtt ctccgggtca ggatcccgca cggacttcac      720

cttgacgatt aacccggtgg aaactgatga cgtcgccact tactactgtc agcagaacaa      780

taaggaccct cccacatttg gcggaggtac gaagcttgaa atcaagaggg cggagccgaa      840

gagctgcgat aaaacgcaca catgccctcc atgccctgca ccggagctct tgggcggacc      900

ttccgtgttt ctgttcccac cgaaacccaa agacaccctg atgatttcgc gcacgccgga      960

ggtaacttgt gtggtggtgg acgtaagcca tgaggacccg gaagtaaagt tcaactggta     1020

tgtcgatggc gtggaggtcc acaatgcgaa aaccaagccg agagaggaac agtataactc     1080

cacgtaccga gtcgtaagcg tgcttacagt gcttcatcaa gattggttga atggtaaaga     1140

atacaaatgc aaggtgtcga acaaagctct gcccgcacca attgagaaaa ctattagcaa     1200

ggcgaagggg cagcccaggg aaccccaagt gtatactttg ccgccctcgc gcgatgaact     1260

cactaagaat caagtctcgc tgacgtgtct cgtcaagggg ttttacccga gcgacatcgc     1320

ggtggagtgg gagtcgaacg gtcaaccgga gaacaattac aaaaccacac ctcccgtgct     1380

cgattcggac ggatcgtttt tcctctattc caaattgacc gtcgataagt cgcgatggca     1440

gcagggtaat gtattttcgt gttcggtaat gcacgaagcc ctccacaacc attatacgca     1500

gaagtcgctg tccctgtcgc ccggaaagaa agacccgaag gcggccgcaa ttgaagttat     1560

gtatcctcct ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg     1620

gaaacacctt tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt     1680

ggtggttggg ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt     1740

ctgggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg     1800

ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc     1860

ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca     1920

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     1980

gagacgtggc cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg     2040

cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa     2100

aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac     2160

caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgctaa                 2209


<210>  98
<211>  1501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  98
ccctcgagcc gccaccatgg ttctgcttgt gacctccctg cttctctgcg aactccctca       60

tccggcattc ctgctcatcc ccgacaccca agtccaactc cagcagagcg gagccgagct      120

ggtgaagccg ggagcgagcg tcaaaatcag ctgtaaagcc tccggctacg ccttcagctc      180

atactggatg aactgggtga agcaaagacc gggaaagggg ttggaatgga tcggacaaat      240

ctacccggga gatggagata ctacctacaa tgggaagttt aaaggaaagg ccactctgac      300

cgctgataag tcctcgtcca cggtctacat gcagctcaac tcactgactt cggaggatag      360

cgccgtgtac ttctgcgtgc gctactacta cggatcatca ggatacttcg actactgggg      420

ccaaggtacc actctcaccg tgtcgtcggg aggaggcggc tccggcggtg gaggatccgg      480

aggcggaggc tcagacgtgc agatgattca gactcccgac tcgctggcgg tgtccctcgg      540

tcagagggcc accatttcgt gccgggcttc ggagtcagtg gacaattacg gcatcagctt      600

tatgcactgg tatcagcaaa agccaggcca gtccccaaag ttgctgatct accgcgcatc      660

gaatctggag tccggcatcc cagctcggtt cagcgggagc ggatcgagaa ctgactttac      720

gctgaccatc aacccggtcg aaaccgatga cgtcgcaact tattactgcc agcagaacaa      780

caaggaccct ccgaccttcg gtggagggac taagctggaa atcaaacgcg cggcggccgc      840

aattgaagtt atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat      900

ccatgtgaaa gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt      960

ttgggtgctg gtggtggttg ggggagtcct ggcttgctat agcttgctag taacagtggc     1020

ctttattatt ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa     1080

catgactccc cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg     1140

cgacttcgca gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta     1200

ccagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga     1260

tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa     1320

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     1380

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     1440

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     1500

a                                                                     1501


<210>  99
<211>  2221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  99
ccctcgagcc gccaccatgg ttcttctcgt gacaagcctt cttctctgcg aattgcccca       60

cccagccttt ttgcttatcc ccgacaccca agtccagctg cagcaatcag gggccgagtt      120

ggtcaagcct ggggcatcgg tcaaaatctc atgtaaagcc tcgggatatg cgttctcgtc      180

atactggatg aattgggtca agcagcggcc aggaaaggga ctggaatgga tcgggcaaat      240

ctacccaggg gatggagata caacatataa cgggaagttt aaagggaaag caactctcac      300

tgcggacaag tcatcatcga cggtatacat gcagcttaac tcattgacaa gcgaggactc      360

ggcggtctat ttctgcgtac ggtattacta cggatcgtcg gggtacttcg attattgggg      420

tcagggaacc acgctgacag tgtccagcgg aggtggcggg tccggaggcg gaggatccgg      480

tggcggtgga agcgatgtgc agatgatcca gacgccggac tcactcgcgg tgtcactcgg      540

gcagcgggcg acgatttcat gcagagcctc cgagtcggtg gacaattacg gtatctcctt      600

catgcattgg tatcagcaga aacccgggca gtcgcccaag ctgttgatct acagagcgtc      660

caaccttgag tcggggattc ccgctaggtt ctccgggtca ggatcccgca cggacttcac      720

cttgacgatt aacccggtgg aaactgatga cgtcgccact tactactgtc agcagaacaa      780

taaggaccct cccacatttg gcggaggtac gaagcttgaa atcaagaggg cggagccgaa      840

gagctgcgat aaaacgcaca catgccctcc atgccctgca ccggagctct tgggcggacc      900

ttccgtgttt ctgttcccac cgaaacccaa agacaccctg atgatttcgc gcacgccgga      960

ggtaacttgt gtggtggtgg acgtaagcca tgaggacccg gaagtaaagt tcaactggta     1020

tgtcgatggc gtggaggtcc acaatgcgaa aaccaagccg agagaggaac agtataactc     1080

cacgtaccga gtcgtaagcg tgcttacagt gcttcatcaa gattggttga atggtaaaga     1140

atacaaatgc aaggtgtcga acaaagctct gcccgcacca attgagaaaa ctattagcaa     1200

ggcgaagggg cagcccaggg aaccccaagt gtatactttg ccgccctcgc gcgatgaact     1260

cactaagaat caagtctcgc tgacgtgtct cgtcaagggg ttttacccga gcgacatcgc     1320

ggtggagtgg gagtcgaacg gtcaaccgga gaacaattac aaaaccacac ctcccgtgct     1380

cgattcggac ggatcgtttt tcctctattc caaattgacc gtcgataagt cgcgatggca     1440

gcagggtaat gtattttcgt gttcggtaat gcacgaagcc ctccacaacc attatacgca     1500

gaagtcgctg tccctgtcgc ccggaaagaa agacccgaag gcggccgcaa ccacgacgcc     1560

agcgccgcga ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc     1620

agaggcgtgc cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg     1680

tgatatctac atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt     1740

tatcaccctt tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt     1800

tatgagacca gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga     1860

agaagaagga ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta     1920

caagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga     1980

tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa     2040

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     2100

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     2160

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     2220

a                                                                     2221


<210>  100
<211>  1513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  100
ccctcgagcc gccaccatgg ttctgcttgt gacctccctg cttctctgcg aactccctca       60

tccggcattc ctgctcatcc ccgacaccca agtccaactc cagcagagcg gagccgagct      120

ggtgaagccg ggagcgagcg tcaaaatcag ctgtaaagcc tccggctacg ccttcagctc      180

atactggatg aactgggtga agcaaagacc gggaaagggg ttggaatgga tcggacaaat      240

ctacccggga gatggagata ctacctacaa tgggaagttt aaaggaaagg ccactctgac      300

cgctgataag tcctcgtcca cggtctacat gcagctcaac tcactgactt cggaggatag      360

cgccgtgtac ttctgcgtgc gctactacta cggatcatca ggatacttcg actactgggg      420

ccaaggtacc actctcaccg tgtcgtcggg aggaggcggc tccggcggtg gaggatccgg      480

aggcggaggc tcagacgtgc agatgattca gactcccgac tcgctggcgg tgtccctcgg      540

tcagagggcc accatttcgt gccgggcttc ggagtcagtg gacaattacg gcatcagctt      600

tatgcactgg tatcagcaaa agccaggcca gtccccaaag ttgctgatct accgcgcatc      660

gaatctggag tccggcatcc cagctcggtt cagcgggagc ggatcgagaa ctgactttac      720

gctgaccatc aacccggtcg aaaccgatga cgtcgcaact tattactgcc agcagaacaa      780

caaggaccct ccgaccttcg gtggagggac taagctggaa atcaaacgcg cggcggccgc      840

aaccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct      900

gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct      960

ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct     1020

cctgtcactg gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt     1080

caaacaacca tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg     1140

atttccagaa gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga     1200

cgcccccgcg tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag     1260

agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc     1320

gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga     1380

ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct     1440

ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct     1500

gccccctcgc taa                                                        1513


<210>  101
<211>  2401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  101
ccctcgagcc gccaccatgg ttcttctcgt gacaagcctt cttctctgcg aattgcccca       60

cccagccttt ttgcttatcc ccgacaccca agtccagctg cagcaatcag gggccgagtt      120

ggtcaagcct ggggcatcgg tcaaaatctc atgtaaagcc tcgggatatg cgttctcgtc      180

atactggatg aattgggtca agcagcggcc aggaaaggga ctggaatgga tcgggcaaat      240

ctacccaggg gatggagata caacatataa cgggaagttt aaagggaaag caactctcac      300

tgcggacaag tcatcatcga cggtatacat gcagcttaac tcattgacaa gcgaggactc      360

ggcggtctat ttctgcgtac ggtattacta cggatcgtcg gggtacttcg attattgggg      420

tcagggaacc acgctgacag tgtccagcgg aggtggcggg tccggaggcg gaggatccgg      480

tggcggtgga agcgatgtgc agatgatcca gacgccggac tcactcgcgg tgtcactcgg      540

gcagcgggcg acgatttcat gcagagcctc cgagtcggtg gacaattacg gtatctcctt      600

catgcattgg tatcagcaga aacccgggca gtcgcccaag ctgttgatct acagagcgtc      660

caaccttgag tcggggattc ccgctaggtt ctccgggtca ggatcccgca cggacttcac      720

cttgacgatt aacccggtgg aaactgatga cgtcgccact tactactgtc agcagaacaa      780

taaggaccct cccacatttg gcggaggtac gaagcttgaa atcaagaggg cggagccgaa      840

gagctgcgat aaaacgcaca catgccctcc atgccctgca ccggagctct tgggcggacc      900

ttccgtgttt ctgttcccac cgaaacccaa agacaccctg atgatttcgc gcacgccgga      960

ggtaacttgt gtggtggtgg acgtaagcca tgaggacccg gaagtaaagt tcaactggta     1020

tgtcgatggc gtggaggtcc acaatgcgaa aaccaagccg agagaggaac agtataactc     1080

cacgtaccga gtcgtaagcg tgcttacagt gcttcatcaa gattggttga atggtaaaga     1140

atacaaatgc aaggtgtcga acaaagctct gcccgcacca attgagaaaa ctattagcaa     1200

ggcgaagggg cagcccaggg aaccccaagt gtatactttg ccgccctcgc gcgatgaact     1260

cactaagaat caagtctcgc tgacgtgtct cgtcaagggg ttttacccga gcgacatcgc     1320

ggtggagtgg gagtcgaacg gtcaaccgga gaacaattac aaaaccacac ctcccgtgct     1380

cgattcggac ggatcgtttt tcctctattc caaattgacc gtcgataagt cgcgatggca     1440

gcagggtaat gtattttcgt gttcggtaat gcacgaagcc ctccacaacc attatacgca     1500

gaagtcgctg tccctgtcgc ccggaaagaa agacccgaag gcggccgcat tcgtgccggt     1560

cttcctgcca gcgaagccca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac     1620

catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc     1680

agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg     1740

gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcaacc acaggaacag     1800

gagtaagagg agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg     1860

gcccacccgc aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc     1920

ccgtttctct gttgttaaac ggggcagaaa gaagctcctg tatatattca aacaaccatt     1980

tatgagacca gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga     2040

agaagaagga ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta     2100

ccagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga     2160

tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa     2220

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     2280

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     2340

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     2400

a                                                                     2401


<210>  102
<211>  1693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  102
ccctcgagcc gccaccatgg ttctgcttgt gacctccctg cttctctgcg aactccctca       60

tccggcattc ctgctcatcc ccgacaccca agtccaactc cagcagagcg gagccgagct      120

ggtgaagccg ggagcgagcg tcaaaatcag ctgtaaagcc tccggctacg ccttcagctc      180

atactggatg aactgggtga agcaaagacc gggaaagggg ttggaatgga tcggacaaat      240

ctacccggga gatggagata ctacctacaa tgggaagttt aaaggaaagg ccactctgac      300

cgctgataag tcctcgtcca cggtctacat gcagctcaac tcactgactt cggaggatag      360

cgccgtgtac ttctgcgtgc gctactacta cggatcatca ggatacttcg actactgggg      420

ccaaggtacc actctcaccg tgtcgtcggg aggaggcggc tccggcggtg gaggatccgg      480

aggcggaggc tcagacgtgc agatgattca gactcccgac tcgctggcgg tgtccctcgg      540

tcagagggcc accatttcgt gccgggcttc ggagtcagtg gacaattacg gcatcagctt      600

tatgcactgg tatcagcaaa agccaggcca gtccccaaag ttgctgatct accgcgcatc      660

gaatctggag tccggcatcc cagctcggtt cagcgggagc ggatcgagaa ctgactttac      720

gctgaccatc aacccggtcg aaaccgatga cgtcgcaact tattactgcc agcagaacaa      780

caaggaccct ccgaccttcg gtggagggac taagctggaa atcaaacgcg cggcggccgc      840

attcgtgccg gtcttcctgc cagcgaagcc caccacgacg ccagcgccgc gaccaccaac      900

accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc      960

ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc     1020

gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa     1080

ccacaggaac aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc     1140

ccgccgcccc gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc     1200

agcctatcgc tcccgtttct ctgttgttaa acggggcaga aagaagctcc tgtatatatt     1260

caaacaacca tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg     1320

atttccagaa gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga     1380

cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag     1440

agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc     1500

gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga     1560

ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct     1620

ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct     1680

gccccctcgc taa                                                        1693


<210>  103
<211>  2200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  103
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagagccca agagctgcga      840

caagacccac acctgtcccc cttgtcctgc ccctgaactg ctgggcggac ctagcgtgtt      900

cctgttcccc ccaaagccca aggataccct gatgatcagc aggacccccg aagtgacctg      960

cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg     1020

cgtggaagtg cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg     1080

ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg     1140

caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg     1200

ccagccccgc gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa     1260

ccaggtgtcc ctgacctgtc tcgtgaaggg cttctacccc tccgatatcg ccgtggaatg     1320

ggagagcaac ggccagcccg agaacaacta caagaccacc ccccctgtgc tggactccga     1380

cggctcattc ttcctgtaca gcaagctgac agtggataag tcccggtggc agcagggcaa     1440

cgtgttcagc tgctccgtga tgcacgaagc cctgcacaac cactacaccc agaaaagcct     1500

gtccctgagc cctggcaaga aggaccccaa agcggccgca attgaagtta tgtatcctcc     1560

tccttaccta gacaatgaga agagcaatgg aaccattatc catgtgaaag ggaaacacct     1620

ttgtccaagt cccctatttc ccggaccttc taagcccttt tgggtgctgg tggtggttgg     1680

gggagtcctg gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag     1740

gagtaagagg agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg     1800

gcccacccgc aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc     1860

cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct     1920

ctataacgag ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg     1980

ccgggaccct gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa     2040

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg     2100

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac     2160

ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa                           2200


<210>  104
<211>  1492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  104
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagcggccg caattgaagt      840

tatgtatcct cctccttacc tagacaatga gaagagcaat ggaaccatta tccatgtgaa      900

agggaaacac ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct      960

ggtggtggtt gggggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat     1020

tttctgggtg aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc     1080

ccgccgcccc gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc     1140

agcctatcgc tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg     1200

ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga     1260

caagagacgt ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga     1320

aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat     1380

gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc     1440

caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct aa             1492


<210>  105
<211>  2212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  105
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagagccca agagctgcga      840

caagacccac acctgtcccc cttgtcctgc ccctgaactg ctgggcggac ctagcgtgtt      900

cctgttcccc ccaaagccca aggataccct gatgatcagc aggacccccg aagtgacctg      960

cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg     1020

cgtggaagtg cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg     1080

ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg     1140

caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg     1200

ccagccccgc gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa     1260

ccaggtgtcc ctgacctgtc tcgtgaaggg cttctacccc tccgatatcg ccgtggaatg     1320

ggagagcaac ggccagcccg agaacaacta caagaccacc ccccctgtgc tggactccga     1380

cggctcattc ttcctgtaca gcaagctgac agtggataag tcccggtggc agcagggcaa     1440

cgtgttcagc tgctccgtga tgcacgaagc cctgcacaac cactacaccc agaaaagcct     1500

gtccctgagc cctggcaaga aggaccccaa agcggccgca accacgacgc cagcgccgcg     1560

accaccaaca ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg     1620

ccggccagcg gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta     1680

catctgggcg cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct     1740

ttactgcaaa cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc     1800

agtacaaact actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg     1860

aggatgtgaa ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg     1920

ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga     1980

caagagacgt ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga     2040

aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat     2100

gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc     2160

caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct aa             2212


<210>  106
<211>  1504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  106
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagcggccg caaccacgac      840

gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg      900

cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc      960

ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact     1020

ggttatcacc ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc     1080

atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga     1140

agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc     1200

gtacaagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta     1260

cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa     1320

gaaccctcag gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag     1380

tgagattggg atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg     1440

tctcagtaca gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg     1500

ctaa                                                                  1504


<210>  107
<211>  2392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  107
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagagccca agagctgcga      840

caagacccac acctgtcccc cttgtcctgc ccctgaactg ctgggcggac ctagcgtgtt      900

cctgttcccc ccaaagccca aggataccct gatgatcagc aggacccccg aagtgacctg      960

cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg     1020

cgtggaagtg cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg     1080

ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg     1140

caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg     1200

ccagccccgc gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa     1260

ccaggtgtcc ctgacctgtc tcgtgaaggg cttctacccc tccgatatcg ccgtggaatg     1320

ggagagcaac ggccagcccg agaacaacta caagaccacc ccccctgtgc tggactccga     1380

cggctcattc ttcctgtaca gcaagctgac agtggataag tcccggtggc agcagggcaa     1440

cgtgttcagc tgctccgtga tgcacgaagc cctgcacaac cactacaccc agaaaagcct     1500

gtccctgagc cctggcaaga aggaccccaa agcggccgca ttcgtgccgg tcttcctgcc     1560

agcgaagccc accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc     1620

gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac     1680

gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg     1740

ggtccttctc ctgtcactgg ttatcaccct ttactgcaac cacaggaaca ggagtaagag     1800

gagcaggctc ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg     1860

caagcattac cagccctatg ccccaccacg cgacttcgca gcctatcgct cccgtttctc     1920

tgttgttaaa cggggcagaa agaagctcct gtatatattc aaacaaccat ttatgagacc     1980

agtacaaact actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg     2040

aggatgtgaa ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg     2100

ccagaaccag ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga     2160

caagagacgt ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga     2220

aggcctgtac aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat     2280

gaaaggcgag cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc     2340

caccaaggac acctacgacg cccttcacat gcaggccctg ccccctcgct aa             2392


<210>  108
<211>  1684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  108
ccctcgagcc gccaccatgg ttctgctcgt gacaagcctg ctgctgtgcg agctgcccca       60

ccctgccttt ctgctgatcc ccgacaccga cgtgcagctg caggaatctg gacccgtgct      120

cgtgaaaacc ggcgccagcg tgaagatgag ctgtaccgcc agcggctaca ccttcaccga      180

ccacttcatg gactgggtca agcagagcca cggcaagagc ctggaatgga tcggcagcct      240

gaacccctac agcggcggca ccagctacaa ccagaagttc aagggcaagg ccaccctgac      300

cgtggacaag agcagcagca ccgcctacat ggaactgaac agcctgacca gcgtggacag      360

cgccgtgtac tactgcgcca gacacaactg gggcgcctac ttcgactatt ggggccaggg      420

cacaaccctg acagtgtcta gcggaggcgg aggatctggc ggcggaggaa gtggcggagg      480

gggatctgat atcgtgatga cccaggccgc tcccagcgtg ccagtgacac ctggcgagag      540

cgtgtccatc agctgcagaa gcagcaagtc cctgctgcac agcaacggca atacctacct      600

gtactggttc ctgcagaggc ctggccagag cccccagcgg ctgatctact acatgagcaa      660

cctggccagc ggcgtgcccg acagattttc tggcagaggc agcggcaccg acttcaccct      720

gagaatcagc cgggtggaag ccgaggacgt gggcgtgtac tattgcatgc agggcctgga      780

agatccttac accttcggcg gaggcaccaa gctggaaatc aaagcggccg cattcgtgcc      840

ggtcttcctg ccagcgaagc ccaccacgac gccagcgccg cgaccaccaa caccggcgcc      900

caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg      960

cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc     1020

cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca accacaggaa     1080

caggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc     1140

cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg     1200

ctcccgtttc tctgttgtta aacggggcag aaagaagctc ctgtatatat tcaaacaacc     1260

atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga     1320

agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc     1380

gtaccagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta     1440

cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa     1500

gaaccctcag gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag     1560

tgagattggg atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg     1620

tctcagtaca gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg     1680

ctaa                                                                  1684


<210>  109
<211>  2197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  109
ccctcgagcc gccaccatgg ttcttctcgt gactagcctc ctgctgtgcg aacttccaca       60

tccagctttc ctgcttatcc cagacaccgc cctccaactc cagcaaagcg gtgctgaact      120

tgtgaggcct ggcgcttctg tcaccctgag ctgcaaagcc agcggttata ccttcaccga      180

ttacgaaatg cattgggtga agcagacccc agtgcatggt ctggagtgga ttggagctat      240

cgaccccgaa actggaggga ctgcctacaa ccagaagttt gagggaaagg ccatccttac      300

tgccgacaag tcatcatcta ccgcatacat ggagctgagg tcactgacct ccgaggactc      360

ccccgtgtac tattgcgcca gaaggaggta ctacggttca tcttccttcg attattgggg      420

acagggaact actctgaccg tcagctctgg cggtggtgga tcaggtggag gcggaagcgg      480

agggggaggt tcagacgtcc agatgattca gactccttcc agcctttctg cctcactcgg      540

ggaccgcgtg accatctcat gtagagcctc ccaagacatc ggcaattacc ttaattggta      600

tcaacaaaaa cctgatggca ctgtgaagct cctgatctac tacacctctc ggcttcactc      660

aggggtcccc agccggttct ctggctctgg ttcagggacc gaatactctc tcaccattag      720

caatctcgaa caagaggaca tcgcaactta cttctgccag cagggaagcg cactgccgcc      780

caccttcgga ggaggaacca agctggaaat caatcgggcc gagccgaaga gctgcgacaa      840

gactcatact tgtcctcctt gtccagcccc ggaactgctc ggcggaccct ccgtgttcct      900

gttcccgccc aagcccaagg acactcttat gatcagccgc acccccgaag tgacttgcgt      960

cgtcgtggac gtgagccacg aggaccctga agtgaagttc aactggtatg tggacggagt     1020

cgaagtgcat aacgccaaaa ccaaaccccg cgaggagcaa tacaattcaa cctatcgcgt     1080

ggtgagcgtg ctcaccgtgc tgcaccagga ctggcttaac ggtaaagagt acaagtgtaa     1140

agtgagcaac aaagctctgc ccgctcctat tgagaaaact atcagcaagg ctaagggaca     1200

gcctcgggaa cctcaagtgt atacccttcc ccctagccgg gatgaactga ccaagaatca     1260

agtcagcctt acttgtctgg tcaaggggtt ctacccatcc gacattgcag tggaatggga     1320

gtcaaacggg cagcccgaga acaattacaa gaccaccccg cctgtgctgg acagcgacgg     1380

atcattcttt ctttactcaa agctgactgt ggataagtca agatggcagc agggtaacgt     1440

gttttcttgc agcgtcatgc acgaggccct gcacaaccat tatacccaga agagcctgtc     1500

actgtctccg ggaaagaagg accctaaggc ggccgcaatt gaagttatgt atcctcctcc     1560

ttacctagac aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg     1620

tccaagtccc ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggggg     1680

agtcctggct tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag     1740

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc     1800

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag     1860

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta     1920

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg     1980

ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga     2040

actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg     2100

gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta     2160

cgacgccctt cacatgcagg ccctgccccc tcgctaa                              2197


<210>  110
<211>  1489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  110
ccctcgagcc gccaccatgg ttctccttgt gacctcactc ctgctgtgcg aactgccgca       60

tccagccttc ctgctgatcc ccgacactgc gctccaactg cagcaatccg gagctgaatt      120

ggtgcggcca ggtgcgtccg tgacgttgag ctgcaaggca tccggataca cctttaccga      180

ctacgagatg cactgggtca aacagactcc tgtccacggc ctcgaatgga ttggagcaat      240

cgacccagaa actggaggga ccgcgtacaa ccagaagttt gaaggaaagg ccattttgac      300

tgccgacaaa tcctcctcga ccgcctacat ggaactgaga tccctgactt cggaggattc      360

gccggtgtac tactgtgcac gccgcagata ctacgggagc tcgtcgttcg actactgggg      420

tcagggaacc actctgactg tctcatccgg tggaggcgga tcaggcggtg gagggtcagg      480

cggaggcggc tccgacgtgc agatgatcca gaccccgtcc tcgctctccg cttcgcttgg      540

agatcgggtc acgatcagct gccgcgcttc acaagatatc ggaaactatc tcaactggta      600

ccaacagaag ccggacggaa ctgtgaagct gctcatctac tacacctcgc gccttcatag      660

cggagtgcct tcaaggttca gcggctcggg gtcgggaacc gagtacagcc tgaccatctc      720

aaatctggag caggaagata tcgccactta tttctgccag caaggtagcg ccctccctcc      780

gaccttcgga ggcgggacga agctggagat caatcgggcg gcggccgcaa ttgaagttat      840

gtatcctcct ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg      900

gaaacacctt tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt      960

ggtggttggg ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt     1020

ctgggtgagg agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg     1080

ccgccccggg cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc     1140

ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca     1200

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     1260

gagacgtggc cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg     1320

cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa     1380

aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac     1440

caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgctaa                 1489


<210>  111
<211>  2209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  111
ccctcgagcc gccaccatgg ttcttctcgt gactagcctc ctgctgtgcg aacttccaca       60

tccagctttc ctgcttatcc cagacaccgc cctccaactc cagcaaagcg gtgctgaact      120

tgtgaggcct ggcgcttctg tcaccctgag ctgcaaagcc agcggttata ccttcaccga      180

ttacgaaatg cattgggtga agcagacccc agtgcatggt ctggagtgga ttggagctat      240

cgaccccgaa actggaggga ctgcctacaa ccagaagttt gagggaaagg ccatccttac      300

tgccgacaag tcatcatcta ccgcatacat ggagctgagg tcactgacct ccgaggactc      360

ccccgtgtac tattgcgcca gaaggaggta ctacggttca tcttccttcg attattgggg      420

acagggaact actctgaccg tcagctctgg cggtggtgga tcaggtggag gcggaagcgg      480

agggggaggt tcagacgtcc agatgattca gactccttcc agcctttctg cctcactcgg      540

ggaccgcgtg accatctcat gtagagcctc ccaagacatc ggcaattacc ttaattggta      600

tcaacaaaaa cctgatggca ctgtgaagct cctgatctac tacacctctc ggcttcactc      660

aggggtcccc agccggttct ctggctctgg ttcagggacc gaatactctc tcaccattag      720

caatctcgaa caagaggaca tcgcaactta cttctgccag cagggaagcg cactgccgcc      780

caccttcgga ggaggaacca agctggaaat caatcgggcc gagccgaaga gctgcgacaa      840

gactcatact tgtcctcctt gtccagcccc ggaactgctc ggcggaccct ccgtgttcct      900

gttcccgccc aagcccaagg acactcttat gatcagccgc acccccgaag tgacttgcgt      960

cgtcgtggac gtgagccacg aggaccctga agtgaagttc aactggtatg tggacggagt     1020

cgaagtgcat aacgccaaaa ccaaaccccg cgaggagcaa tacaattcaa cctatcgcgt     1080

ggtgagcgtg ctcaccgtgc tgcaccagga ctggcttaac ggtaaagagt acaagtgtaa     1140

agtgagcaac aaagctctgc ccgctcctat tgagaaaact atcagcaagg ctaagggaca     1200

gcctcgggaa cctcaagtgt atacccttcc ccctagccgg gatgaactga ccaagaatca     1260

agtcagcctt acttgtctgg tcaaggggtt ctacccatcc gacattgcag tggaatggga     1320

gtcaaacggg cagcccgaga acaattacaa gaccaccccg cctgtgctgg acagcgacgg     1380

atcattcttt ctttactcaa agctgactgt ggataagtca agatggcagc agggtaacgt     1440

gttttcttgc agcgtcatgc acgaggccct gcacaaccat tatacccaga agagcctgtc     1500

actgtctccg ggaaagaagg accctaaggc ggccgcaacc acgacgccag cgccgcgacc     1560

accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg     1620

gccagcggcg gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat     1680

ctgggcgccc ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta     1740

ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt     1800

acaaactact caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg     1860

atgtgaactg agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca     1920

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     1980

gagacgtggc cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg     2040

cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa     2100

aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac     2160

caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgctaa                 2209


<210>  112
<211>  1501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  112
ccctcgagcc gccaccatgg ttctccttgt gacctcactc ctgctgtgcg aactgccgca       60

tccagccttc ctgctgatcc ccgacactgc gctccaactg cagcaatccg gagctgaatt      120

ggtgcggcca ggtgcgtccg tgacgttgag ctgcaaggca tccggataca cctttaccga      180

ctacgagatg cactgggtca aacagactcc tgtccacggc ctcgaatgga ttggagcaat      240

cgacccagaa actggaggga ccgcgtacaa ccagaagttt gaaggaaagg ccattttgac      300

tgccgacaaa tcctcctcga ccgcctacat ggaactgaga tccctgactt cggaggattc      360

gccggtgtac tactgtgcac gccgcagata ctacgggagc tcgtcgttcg actactgggg      420

tcagggaacc actctgactg tctcatccgg tggaggcgga tcaggcggtg gagggtcagg      480

cggaggcggc tccgacgtgc agatgatcca gaccccgtcc tcgctctccg cttcgcttgg      540

agatcgggtc acgatcagct gccgcgcttc acaagatatc ggaaactatc tcaactggta      600

ccaacagaag ccggacggaa ctgtgaagct gctcatctac tacacctcgc gccttcatag      660

cggagtgcct tcaaggttca gcggctcggg gtcgggaacc gagtacagcc tgaccatctc      720

aaatctggag caggaagata tcgccactta tttctgccag caaggtagcg ccctccctcc      780

gaccttcgga ggcgggacga agctggagat caatcgggcg gcggccgcaa ccacgacgcc      840

agcgccgcga ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc      900

agaggcgtgc cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg      960

tgatatctac atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt     1020

tatcaccctt tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt     1080

tatgagacca gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga     1140

agaagaagga ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta     1200

caagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga     1260

tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa     1320

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     1380

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     1440

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     1500

a                                                                     1501


<210>  113
<211>  2389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  113
ccctcgagcc gccaccatgg ttcttctcgt gactagcctc ctgctgtgcg aacttccaca       60

tccagctttc ctgcttatcc cagacaccgc cctccaactc cagcaaagcg gtgctgaact      120

tgtgaggcct ggcgcttctg tcaccctgag ctgcaaagcc agcggttata ccttcaccga      180

ttacgaaatg cattgggtga agcagacccc agtgcatggt ctggagtgga ttggagctat      240

cgaccccgaa actggaggga ctgcctacaa ccagaagttt gagggaaagg ccatccttac      300

tgccgacaag tcatcatcta ccgcatacat ggagctgagg tcactgacct ccgaggactc      360

ccccgtgtac tattgcgcca gaaggaggta ctacggttca tcttccttcg attattgggg      420

acagggaact actctgaccg tcagctctgg cggtggtgga tcaggtggag gcggaagcgg      480

agggggaggt tcagacgtcc agatgattca gactccttcc agcctttctg cctcactcgg      540

ggaccgcgtg accatctcat gtagagcctc ccaagacatc ggcaattacc ttaattggta      600

tcaacaaaaa cctgatggca ctgtgaagct cctgatctac tacacctctc ggcttcactc      660

aggggtcccc agccggttct ctggctctgg ttcagggacc gaatactctc tcaccattag      720

caatctcgaa caagaggaca tcgcaactta cttctgccag cagggaagcg cactgccgcc      780

caccttcgga ggaggaacca agctggaaat caatcgggcc gagccgaaga gctgcgacaa      840

gactcatact tgtcctcctt gtccagcccc ggaactgctc ggcggaccct ccgtgttcct      900

gttcccgccc aagcccaagg acactcttat gatcagccgc acccccgaag tgacttgcgt      960

cgtcgtggac gtgagccacg aggaccctga agtgaagttc aactggtatg tggacggagt     1020

cgaagtgcat aacgccaaaa ccaaaccccg cgaggagcaa tacaattcaa cctatcgcgt     1080

ggtgagcgtg ctcaccgtgc tgcaccagga ctggcttaac ggtaaagagt acaagtgtaa     1140

agtgagcaac aaagctctgc ccgctcctat tgagaaaact atcagcaagg ctaagggaca     1200

gcctcgggaa cctcaagtgt atacccttcc ccctagccgg gatgaactga ccaagaatca     1260

agtcagcctt acttgtctgg tcaaggggtt ctacccatcc gacattgcag tggaatggga     1320

gtcaaacggg cagcccgaga acaattacaa gaccaccccg cctgtgctgg acagcgacgg     1380

atcattcttt ctttactcaa agctgactgt ggataagtca agatggcagc agggtaacgt     1440

gttttcttgc agcgtcatgc acgaggccct gcacaaccat tatacccaga agagcctgtc     1500

actgtctccg ggaaagaagg accctaaggc ggccgcattc gtgccggtct tcctgccagc     1560

gaagcccacc acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca     1620

gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag     1680

ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt     1740

ccttctcctg tcactggtta tcacccttta ctgcaaccac aggaacagga gtaagaggag     1800

caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa     1860

gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctccc gtttctctgt     1920

tgttaaacgg ggcagaaaga agctcctgta tatattcaaa caaccattta tgagaccagt     1980

acaaactact caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg     2040

atgtgaactg agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca     2100

gaaccagctc tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa     2160

gagacgtggc cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg     2220

cctgtacaat gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa     2280

aggcgagcgc cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac     2340

caaggacacc tacgacgccc ttcacatgca ggccctgccc cctcgctaa                 2389


<210>  114
<211>  1681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor sequence

<400>  114
ccctcgagcc gccaccatgg ttctccttgt gacctcactc ctgctgtgcg aactgccgca       60

tccagccttc ctgctgatcc ccgacactgc gctccaactg cagcaatccg gagctgaatt      120

ggtgcggcca ggtgcgtccg tgacgttgag ctgcaaggca tccggataca cctttaccga      180

ctacgagatg cactgggtca aacagactcc tgtccacggc ctcgaatgga ttggagcaat      240

cgacccagaa actggaggga ccgcgtacaa ccagaagttt gaaggaaagg ccattttgac      300

tgccgacaaa tcctcctcga ccgcctacat ggaactgaga tccctgactt cggaggattc      360

gccggtgtac tactgtgcac gccgcagata ctacgggagc tcgtcgttcg actactgggg      420

tcagggaacc actctgactg tctcatccgg tggaggcgga tcaggcggtg gagggtcagg      480

cggaggcggc tccgacgtgc agatgatcca gaccccgtcc tcgctctccg cttcgcttgg      540

agatcgggtc acgatcagct gccgcgcttc acaagatatc ggaaactatc tcaactggta      600

ccaacagaag ccggacggaa ctgtgaagct gctcatctac tacacctcgc gccttcatag      660

cggagtgcct tcaaggttca gcggctcggg gtcgggaacc gagtacagcc tgaccatctc      720

aaatctggag caggaagata tcgccactta tttctgccag caaggtagcg ccctccctcc      780

gaccttcgga ggcgggacga agctggagat caatcgggcg gcggccgcat tcgtgccggt      840

cttcctgcca gcgaagccca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac      900

catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc      960

agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg     1020

gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcaacc acaggaacag     1080

gagtaagagg agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg     1140

gcccacccgc aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc     1200

ccgtttctct gttgttaaac ggggcagaaa gaagctcctg tatatattca aacaaccatt     1260

tatgagacca gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga     1320

agaagaagga ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta     1380

ccagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga     1440

tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa     1500

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     1560

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     1620

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     1680

a                                                                     1681


<210>  115
<211>  1620
<212>  PRT
<213>  homo sapiens

<400>  115

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  116
<211>  6267
<212>  DNA
<213>  homo sapiens

<400>  116
agctgcaagt ggcgggcgcc caggcagatg cgatccagcg gctctggggg cggcagcggt       60

ggtagcagct ggtacctccc gccgcctctg ttcggagggt cgcggggcac cgaggtgctt      120

tccggccgcc ctctggtcgg ccacccaaag ccgcgggcgc tgatgatggg tgaggagggg      180

gcggcaagat ttcgggcgcc cctgccctga acgccctcag ctgctgccgc cggggccgct      240

ccagtgcctg cgaactctga ggagccgagg cgccggtgag agcaaggacg ctgcaaactt      300

gcgcagcgcg ggggctggga ttcacgccca gaagttcagc aggcagacag tccgaagcct      360

tcccgcagcg gagagatagc ttgagggtgc gcaagacggc agcctccgcc ctcggttccc      420

gcccagaccg ggcagaagag cttggaggag ccaaaaggaa cgcaaaaggc ggccaggaca      480

gcgtgcagca gctgggagcc gccgttctca gccttaaaag ttgcagagat tggaggctgc      540

cccgagaggg gacagacccc agctccgact gcggggggca ggagaggacg gtacccaact      600

gccacctccc ttcaaccata gtagttcctc tgtaccgagc gcagcgagct acagacgggg      660

gcgcggcact cggcgcggag agcgggaggc tcaaggtccc agccagtgag cccagtgtgc      720

ttgagtgtct ctggactcgc ccctgagctt ccaggtctgt ttcatttaga ctcctgctcg      780

cctccgtgca gttgggggaa agcaagagac ttgcgcgcac gcacagtcct ctggagatca      840

ggtggaagga gccgctgggt accaaggact gttcagagcc tcttcccatc tcggggagag      900

cgaagggtga ggctgggccc ggagagcagt gtaaacggcc tcctccggcg ggatgggagc      960

catcgggctc ctgtggctcc tgccgctgct gctttccacg gcagctgtgg gctccgggat     1020

ggggaccggc cagcgcgcgg gctccccagc tgcggggccg ccgctgcagc cccgggagcc     1080

actcagctac tcgcgcctgc agaggaagag tctggcagtt gacttcgtgg tgccctcgct     1140

cttccgtgtc tacgcccggg acctactgct gccaccatcc tcctcggagc tgaaggctgg     1200

caggcccgag gcccgcggct cgctagctct ggactgcgcc ccgctgctca ggttgctggg     1260

gccggcgccg ggggtctcct ggaccgccgg ttcaccagcc ccggcagagg cccggacgct     1320

gtccagggtg ctgaagggcg gctccgtgcg caagctccgg cgtgccaagc agttggtgct     1380

ggagctgggc gaggaggcga tcttggaggg ttgcgtcggg ccccccgggg aggcggctgt     1440

ggggctgctc cagttcaatc tcagcgagct gttcagttgg tggattcgcc aaggcgaagg     1500

gcgactgagg atccgcctga tgcccgagaa gaaggcgtcg gaagtgggca gagagggaag     1560

gctgtccgcg gcaattcgcg cctcccagcc ccgccttctc ttccagatct tcgggactgg     1620

tcatagctcc ttggaatcac caacaaacat gccttctcct tctcctgatt attttacatg     1680

gaatctcacc tggataatga aagactcctt ccctttcctg tctcatcgca gccgatatgg     1740

tctggagtgc agctttgact tcccctgtga gctggagtat tcccctccac tgcatgacct     1800

caggaaccag agctggtcct ggcgccgcat cccctccgag gaggcctccc agatggactt     1860

gctggatggg cctggggcag agcgttctaa ggagatgccc agaggctcct ttctccttct     1920

caacacctca gctgactcca agcacaccat cctgagtccg tggatgagga gcagcagtga     1980

gcactgcaca ctggccgtct cggtgcacag gcacctgcag ccctctggaa ggtacattgc     2040

ccagctgctg ccccacaacg aggctgcaag agagatcctc ctgatgccca ctccagggaa     2100

gcatggttgg acagtgctcc agggaagaat cgggcgtcca gacaacccat ttcgagtggc     2160

cctggaatac atctccagtg gaaaccgcag cttgtctgca gtggacttct ttgccctgaa     2220

gaactgcagt gaaggaacat ccccaggctc caagatggcc ctgcagagct ccttcacttg     2280

ttggaatggg acagtcctcc agcttgggca ggcctgtgac ttccaccagg actgtgccca     2340

gggagaagat gagagccaga tgtgccggaa actgcctgtg ggtttttact gcaactttga     2400

agatggcttc tgtggctgga cccaaggcac actgtcaccc cacactcctc aatggcaggt     2460

caggacccta aaggatgccc ggttccagga ccaccaagac catgctctat tgctcagtac     2520

cactgatgtc cccgcttctg aaagtgctac agtgaccagt gctacgtttc ctgcaccgat     2580

caagagctct ccatgtgagc tccgaatgtc ctggctcatt cgtggagtct tgaggggaaa     2640

cgtgtccttg gtgctagtgg agaacaaaac cgggaaggag caaggcagga tggtctggca     2700

tgtcgccgcc tatgaaggct tgagcctgtg gcagtggatg gtgttgcctc tcctcgatgt     2760

gtctgacagg ttctggctgc agatggtcgc atggtgggga caaggatcca gagccatcgt     2820

ggcttttgac aatatctcca tcagcctgga ctgctacctc accattagcg gagaggacaa     2880

gatcctgcag aatacagcac ccaaatcaag aaacctgttt gagagaaacc caaacaagga     2940

gctgaaaccc ggggaaaatt caccaagaca gacccccatc tttgacccta cagttcattg     3000

gctgttcacc acatgtgggg ccagcgggcc ccatggcccc acccaggcac agtgcaacaa     3060

cgcctaccag aactccaacc tgagcgtgga ggtggggagc gagggccccc tgaaaggcat     3120

ccagatctgg aaggtgccag ccaccgacac ctacagcatc tcgggctacg gagctgctgg     3180

cgggaaaggc gggaagaaca ccatgatgcg gtcccacggc gtgtctgtgc tgggcatctt     3240

caacctggag aaggatgaca tgctgtacat cctggttggg cagcagggag aggacgcctg     3300

ccccagtaca aaccagttaa tccagaaagt ctgcattgga gagaacaatg tgatagaaga     3360

agaaatccgt gtgaacagaa gcgtgcatga gtgggcagga ggcggaggag gagggggtgg     3420

agccacctac gtatttaaga tgaaggatgg agtgccggtg cccctgatca ttgcagccgg     3480

aggtggtggc agggcctacg gggccaagac agacacgttc cacccagaga gactggagaa     3540

taactcctcg gttctagggc taaacggcaa ttccggagcc gcaggtggtg gaggtggctg     3600

gaatgataac acttccttgc tctgggccgg aaaatctttg caggagggtg ccaccggagg     3660

acattcctgc ccccaggcca tgaagaagtg ggggtgggag acaagagggg gtttcggagg     3720

gggtggaggg gggtgctcct caggtggagg aggcggagga tatataggcg gcaatgcagc     3780

ctcaaacaat gaccccgaaa tggatgggga agatggggtt tccttcatca gtccactggg     3840

catcctgtac accccagctt taaaagtgat ggaaggccac ggggaagtga atattaagca     3900

ttatctaaac tgcagtcact gtgaggtaga cgaatgtcac atggaccctg aaagccacaa     3960

ggtcatctgc ttctgtgacc acgggacggt gctggctgag gatggcgtct cctgcattgt     4020

gtcacccacc ccggagccac acctgccact ctcgctgatc ctctctgtgg tgacctctgc     4080

cctcgtggcc gccctggtcc tggctttctc cggcatcatg attgtgtacc gccggaagca     4140

ccaggagctg caagccatgc agatggagct gcagagccct gagtacaagc tgagcaagct     4200

ccgcacctcg accatcatga ccgactacaa ccccaactac tgctttgctg gcaagacctc     4260

ctccatcagt gacctgaagg aggtgccgcg gaaaaacatc accctcattc ggggtctggg     4320

ccatggcgcc tttggggagg tgtatgaagg ccaggtgtcc ggaatgccca acgacccaag     4380

ccccctgcaa gtggctgtga agacgctgcc tgaagtgtgc tctgaacagg acgaactgga     4440

tttcctcatg gaagccctga tcatcagcaa attcaaccac cagaacattg ttcgctgcat     4500

tggggtgagc ctgcaatccc tgccccggtt catcctgctg gagctcatgg cggggggaga     4560

cctcaagtcc ttcctccgag agacccgccc tcgcccgagc cagccctcct ccctggccat     4620

gctggacctt ctgcacgtgg ctcgggacat tgcctgtggc tgtcagtatt tggaggaaaa     4680

ccacttcatc caccgagaca ttgctgccag aaactgcctc ttgacctgtc caggccctgg     4740

aagagtggcc aagattggag acttcgggat ggcccgagac atctacaggg cgagctacta     4800

tagaaaggga ggctgtgcca tgctgccagt taagtggatg cccccagagg ccttcatgga     4860

aggaatattc acttctaaaa cagacacatg gtcctttgga gtgctgctat gggaaatctt     4920

ttctcttgga tatatgccat accccagcaa aagcaaccag gaagttctgg agtttgtcac     4980

cagtggaggc cggatggacc cacccaagaa ctgccctggg cctgtatacc ggataatgac     5040

tcagtgctgg caacatcagc ctgaagacag gcccaacttt gccatcattt tggagaggat     5100

tgaatactgc acccaggacc cggatgtaat caacaccgct ttgccgatag aatatggtcc     5160

acttgtggaa gaggaagaga aagtgcctgt gaggcccaag gaccctgagg gggttcctcc     5220

tctcctggtc tctcaacagg caaaacggga ggaggagcgc agcccagctg ccccaccacc     5280

tctgcctacc acctcctctg gcaaggctgc aaagaaaccc acagctgcag agatctctgt     5340

tcgagtccct agagggccgg ccgtggaagg gggacacgtg aatatggcat tctctcagtc     5400

caaccctcct tcggagttgc acaaggtcca cggatccaga aacaagccca ccagcttgtg     5460

gaacccaacg tacggctcct ggtttacaga gaaacccacc aaaaagaata atcctatagc     5520

aaagaaggag ccacacgaca ggggtaacct ggggctggag ggaagctgta ctgtcccacc     5580

taacgttgca actgggagac ttccgggggc ctcactgctc ctagagccct cttcgctgac     5640

tgccaatatg aaggaggtac ctctgttcag gctacgtcac ttcccttgtg ggaatgtcaa     5700

ttacggctac cagcaacagg gcttgccctt agaagccgct actgcccctg gagctggtca     5760

ttacgaggat accattctga aaagcaagaa tagcatgaac cagcctgggc cctgagctcg     5820

gtcgcacact cacttctctt ccttgggatc cctaagaccg tggaggagag agaggcaatg     5880

gctccttcac aaaccagaga ccaaatgtca cgttttgttt tgtgccaacc tattttgaag     5940

taccaccaaa aaagctgtat tttgaaaatg ctttagaaag gttttgagca tgggttcatc     6000

ctattctttc gaaagaagaa aatatcataa aaatgagtga taaatacaag gcccagatgt     6060

ggttgcataa ggtttttatg catgtttgtt gtatacttcc ttatgcttct ttcaaattgt     6120

gtgtgctctg cttcaatgta gtcagaatta gctgcttcta tgtttcatag ttggggtcat     6180

agatgtttcc ttgccttgtt gatgtggaca tgagccattt gaggggagag ggaacggaaa     6240

taaaggagtt atttgtaatg actaaaa                                         6267


