<Sequence Listing>

<110>    SAMSUNG ELECTRONICS CO., LTD.

<120>    p53-p16 fusion protein and composition for preventing or treating
         cancer comprising the fusion protein

<130>    OPP20141418KR

<150>    KR10-2013-0135035
<151>    2013-11-07

<160>    24

<170>    KopatentIn 1.71

<210>    1
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    transcriptional active domain of p53


<400>    1
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn
  1               5                  10            


<210>    2
<211>    156
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    p16


<400>    2
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu
  1               5                  10                  15 

Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
             20                  25                  30 

Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro
         35                  40                  45 

Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu
     50                  55                  60 

Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg
 65                  70                  75                  80 

Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val
                 85                  90                  95 

Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg
            100                 105                 110 

Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg
        115                 120                 125 

Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg
    130                 135                 140 

Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp
145                 150                 155    


<210>    3
<211>    283
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ub7KR(G76A)-p53-p16-NLS (#86) including his-tag and TEV cleavage
         site


<400>    3
Met Arg Gly Ser His His His His His His Asp Tyr Asp Ile Pro Thr
  1               5                  10                  15 

Thr Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser Gly Ser Met Gln Ile
             20                  25                  30 

Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro
         35                  40                  45 

Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly
     50                  55                  60 

Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu
 65                  70                  75                  80 

Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu
                 85                  90                  95 

His Leu Val Leu Arg Leu Arg Gly Ala Glu Phe Glu Thr Phe Ser Asp
            100                 105                 110 

Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met Glu Pro Ala Ala Gly
        115                 120                 125 

Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala Thr Ala Ala Ala Arg
    130                 135                 140 

Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu Ala Gly Ala Leu Pro
145                 150                 155                 160 

Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln Val Met Met Met
                165                 170                 175 

Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly Ala Glu Pro
            180                 185                 190 

Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His Asp Ala Ala
        195                 200                 205 

Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg Ala Gly Ala
    210                 215                 220 

Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val Asp Leu Ala
225                 230                 235                 240 

Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg Ala Ala Ala
                245                 250                 255 

Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala Ala Glu Gly
            260                 265                 270 

Pro Ser Asp Ile Pro Asp Lys Lys Lys Arg Lys
        275                 280            


<210>    4
<211>    316
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ub7KR(G76A)-MTS-p53-p16-NLS-SABP (#82) including his-tag and TEV
         cleavage site


<400>    4
Met Arg Gly Ser His His His His His His Asp Tyr Asp Ile Pro Thr
  1               5                  10                  15 

Thr Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser Gly Ser Met Gln Ile
             20                  25                  30 

Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro
         35                  40                  45 

Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly
     50                  55                  60 

Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu
 65                  70                  75                  80 

Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu
                 85                  90                  95 

His Leu Val Leu Arg Leu Arg Gly Ala Glu Phe Ala Ala Val Ala Leu
            100                 105                 110 

Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro Glu Thr Phe Ser Asp
        115                 120                 125 

Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met Glu Pro Ala Ala Gly
    130                 135                 140 

Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala Thr Ala Ala Ala Arg
145                 150                 155                 160 

Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu Ala Gly Ala Leu Pro
                165                 170                 175 

Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln Val Met Met Met
            180                 185                 190 

Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly Ala Glu Pro
        195                 200                 205 

Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His Asp Ala Ala
    210                 215                 220 

Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg Ala Gly Ala
225                 230                 235                 240 

Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val Asp Leu Ala
                245                 250                 255 

Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg Ala Ala Ala
            260                 265                 270 

Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala Ala Glu Gly
        275                 280                 285 

Pro Ser Asp Ile Pro Asp Lys Lys Lys Arg Lys Gly Gly Gly Ser Asp
    290                 295                 300 

Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp
305                 310                 315    


<210>    5
<211>    328
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ub7KR(G76A)-MTS-p53-p16-NLS-SABP (#82) including his-tag and TEV
         cleavage site


<400>    5
Met Arg Gly Ser His His His His His His Asp Tyr Asp Ile Pro Thr
  1               5                  10                  15 

Thr Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser Gly Ser Met Gln Ile
             20                  25                  30 

Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro
         35                  40                  45 

Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly
     50                  55                  60 

Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu
 65                  70                  75                  80 

Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu
                 85                  90                  95 

His Leu Val Leu Arg Leu Arg Gly Ala Glu Phe Ala Ala Val Ala Leu
            100                 105                 110 

Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro Glu Thr Phe Ser Asp
        115                 120                 125 

Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met Ala Glu Pro Trp Gly
    130                 135                 140 

Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly Asp Leu Glu Gln Leu Thr
145                 150                 155                 160 

Ser Leu Leu Gln Asn Asn Val Asn Val Asn Ala Gln Asn Gly Phe Gly
                165                 170                 175 

Arg Thr Ala Leu Gln Val Met Lys Leu Gly Asn Pro Glu Ile Ala Arg
            180                 185                 190 

Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp Leu Lys Asp Arg Thr Gly
        195                 200                 205 

Asn Ala Val Ile His Asp Ala Ala Arg Ala Gly Phe Leu Asp Thr Leu
    210                 215                 220 

Gln Thr Leu Leu Glu Phe Gln Ala Asp Val Asn Ile Glu Asp Asn Glu
225                 230                 235                 240 

Gly Asn Leu Pro Leu His Leu Ala Ala Lys Glu Gly His Leu Arg Val
                245                 250                 255 

Val Glu Phe Leu Val Lys His Thr Ala Ser Asn Val Gly His Arg Asn
            260                 265                 270 

His Lys Gly Asp Thr Ala Cys Asp Leu Ala Arg Leu Tyr Gly Arg Asn
        275                 280                 285 

Glu Val Val Ser Leu Met Gln Ala Asn Gly Ala Gly Gly Ala Thr Asn
    290                 295                 300 

Leu Gln Lys Lys Lys Arg Lys Gly Gly Gly Ser Asp Ile Cys Leu Pro
305                 310                 315                 320 

Arg Trp Gly Cys Leu Trp Glu Asp
                325            


<210>    6
<211>    171
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    p53-p16 conjugate


<400>    6
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met
  1               5                  10                  15 

Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala
             20                  25                  30 

Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu
         35                  40                  45 

Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile
     50                  55                  60 

Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu
 65                  70                  75                  80 

His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro
                 85                  90                  95 

Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu
            100                 105                 110 

His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu
        115                 120                 125 

Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr
    130                 135                 140 

Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile
145                 150                 155                 160 

Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp
                165                 170    


<210>    7
<211>    393
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    p53


<400>    7
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
  1               5                  10                  15 

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu
             20                  25                  30 

Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp
         35                  40                  45 

Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
     50                  55                  60 

Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro
 65                  70                  75                  80 

Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser
                 85                  90                  95 

Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly
            100                 105                 110 

Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro
        115                 120                 125 

Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln
    130                 135                 140 

Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met
145                 150                 155                 160 

Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
                165                 170                 175 

Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
            180                 185                 190 

His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
        195                 200                 205 

Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu
    210                 215                 220 

Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser
225                 230                 235                 240 

Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr
                245                 250                 255 

Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
            260                 265                 270 

Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn
        275                 280                 285 

Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
    290                 295                 300 

Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305                 310                 315                 320 

Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu
                325                 330                 335 

Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp
            340                 345                 350 

Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His
        355                 360                 365 

Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met
    370                 375                 380 

Phe Lys Thr Glu Gly Pro Asp Ser Asp
385                 390            


<210>    8
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    membrane-translocation sequence (MTS)


<400>    8
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro
  1               5                  10                  15 




<210>    9
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MTS fragment


<400>    9
Ala Ala Val Ala Leu Leu Pro
  1               5        


<210>    10
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MTS fragment


<400>    10
Ala Val Leu Leu Ala Leu Leu Ala Pro
  1               5                


<210>    11
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    tMTS


<400>    11
Ala Val Leu Leu Ala Leu Leu Ala Ala
  1               5                


<210>    12
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MTS variant


<400>    12
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Ala
  1               5                  10                  15 




<210>    13
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SV40 large T antigen NLS


<400>    13
Lys Lys Lys Arg Lys
  1               5


<210>    14
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SV40 large T antigen NLS


<400>    14
Pro Lys Lys Lys Arg Lys Val
  1               5        


<210>    15
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    c-Myc NLS


<400>    15
Pro Ala Ala Lys Arg Val Lys Leu Asp
  1               5                


<210>    16
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    nucleoplasmin NLS


<400>    16
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys
  1               5                  10                  15 




<210>    17
<211>    76
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ubiquitin


<400>    17
Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu
  1               5                  10                  15 

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp
             20                  25                  30 

Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys
         35                  40                  45 

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu
     50                  55                  60 

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly
 65                  70                  75    


<210>    18
<211>    76
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mutant type Ubiquitin (Ub7KR(G76A))


<400>    18
Met Gln Ile Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu
  1               5                  10                  15 

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp
             20                  25                  30 

Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg
         35                  40                  45 

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu
     50                  55                  60 

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Ala
 65                  70                  75    


<210>    19
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    serum albumin binding peptide (SABP)


<400>    19
Gly Gly Gly Ser Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu
  1               5                  10                  15 

Asp
   


<210>    20
<211>    852
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence encoding Ub7KR(G76A)-p53-p16-NLS (#86)


<400>    20
atgagaggat cgcatcacca tcaccatcac gattacgata tcccaacgac cgaaaacctg         60

tattttcagg gatccggtag tggaagcatg cagattttcg tgagaaccct tacggggagg        120

accatcaccc tcgaagttga accctcggat acgatagaaa atgtaagggc cagaatccag        180

gatagggaag gaatacctcc tgatcagcag agactgatct ttgctggcag gcagctggaa        240

gatggacgta ctttgtctga ctacaatatt caaagggagt ctactcttca tcttgtgttg        300

agacttcgtg gtgctgaatt cgaaacattt tcagacctat ggaaactact tcctgaaaac        360

aagcttatgg agccggcggc ggggagcagc atggagcctt cggctgactg gctggccacg        420

gccgcggccc ggggtcgggt agaggaggtg cgggcgctgc tggaggcggg ggcgctgccc        480

aacgcaccga atagttacgg tcggaggccg atccaggtca tgatgatggg cagcgcccga        540

gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgccgaccc cgccactctc        600

acccgacccg tgcacgacgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac        660

cgggccgggg cgcggctgga cgtgcgcgat gcctggggcc gtctgcccgt ggacctggct        720

gaggagctgg gccatcgcga tgtcgcacgg tacctgcgcg cggctgcggg gggcaccaga        780

ggcagtaacc atgcccgcat agatgccgcg gaaggtccct cagacatccc cgataaaaag        840

aagagaaagt aa                                                            852


<210>    21
<211>    951
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence encoding Ub7KR(G76A)-MTS-p53-p16-NLS-SABP
         (#82)


<400>    21
atgagaggat cgcatcacca tcaccatcac gattacgata tcccaacgac cgaaaacctg         60

tattttcagg gatccggtag tggaagcatg cagattttcg tgagaaccct tacggggagg        120

accatcaccc tcgaagttga accctcggat acgatagaaa atgtaagggc cagaatccag        180

gatagggaag gaatacctcc tgatcagcag agactgatct ttgctggcag gcagctggaa        240

gatggacgta ctttgtctga ctacaatatt caaagggagt ctactcttca tcttgtgttg        300

agacttcgtg gtgctgaatt cgccgcggta gcgctgctcc cggcggtcct gctggccttg        360

ctggcgcccg aaacattttc agacctatgg aaactacttc ctgaaaacaa gcttatggag        420

ccggcggcgg ggagcagcat ggagccttcg gctgactggc tggccacggc cgcggcccgg        480

ggtcgggtag aggaggtgcg ggcgctgctg gaggcggggg cgctgcccaa cgcaccgaat        540

agttacggtc ggaggccgat ccaggtcatg atgatgggca gcgcccgagt ggcggagctg        600

ctgctgctcc acggcgcgga gcccaactgc gccgaccccg ccactctcac ccgacccgtg        660

cacgacgctg cccgggaggg cttcctggac acgctggtgg tgctgcaccg ggccggggcg        720

cggctggacg tgcgcgatgc ctggggccgt ctgcccgtgg acctggctga ggagctgggc        780

catcgcgatg tcgcacggta cctgcgcgcg gctgcggggg gcaccagagg cagtaaccat        840

gcccgcatag atgccgcgga aggtccctca gacatccccg ataaaaagaa gagaaagggt        900

ggaggtagtg atatctgtct gcctcgttgg ggttgtctgt gggaagatta a                 951


<210>    22
<211>    987
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence encoding Ub7KR(G76A)-MTS-p53-p18-NLS-SABP
         (#52)


<400>    22
atgagaggat cgcatcacca tcaccatcac gattacgata tcccaacgac cgaaaacctg         60

tattttcagg gatccggtag tggaagcatg cagattttcg tgagaaccct tacggggagg        120

accatcaccc tcgaagttga accctcggat acgatagaaa atgtaagggc cagaatccag        180

gatagggaag gaatacctcc tgatcagcag agactgatct ttgctggcag gcagctggaa        240

gatggacgta ctttgtctga ctacaatatt caaagggagt ctactcttca tcttgtgttg        300

agacttcgtg gtgctgaatt cgccgcggta gcgctgctcc cggcggtcct gctggccttg        360

ctggcgcccg aaacattttc agacctatgg aaactacttc ctgaaaacaa gcttatggcc        420

gagccttggg ggaacgagtt ggcgtccgca gctgccaggg gggacctaga gcaacttact        480

agtttgttgc aaaataatgt aaacgtcaat gcacaaaatg gatttggaag gactgcgctg        540

caggttatga aacttggaaa tcccgagatt gccaggagac tgctacttag aggtgctaat        600

cccgatttga aagaccgaac tggtaatgct gtcattcatg atgcggccag agcaggtttc        660

ctggacactt tacagacttt gctggagttt caagctgatg ttaacatcga ggataatgaa        720

gggaacctgc ccttgcactt ggctgccaaa gaaggccacc tccgggtggt ggagttcctg        780

gtgaagcaca cggccagcaa tgtggggcat cggaaccata agggggacac cgcctgtgat        840

ttggccaggc tctatgggag gaatgaggtt gttagcctga tgcaggcaaa cggggctggg        900

ggagccacaa atcttcaaaa aaagaagaga aagggtggag gtagtgatat ctgtctgcct        960

cgttggggtt gtctgtggga agattaa                                            987


<210>    23
<211>    254
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ub7KR(G76A)-p53-p16-NLS


<400>    23
Met Gln Ile Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu
  1               5                  10                  15 

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp
             20                  25                  30 

Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg
         35                  40                  45 

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu
     50                  55                  60 

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Ala Glu Phe Glu Thr
 65                  70                  75                  80 

Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met Glu Pro
                 85                  90                  95 

Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala Thr Ala
            100                 105                 110 

Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu Ala Gly
        115                 120                 125 

Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln Val
    130                 135                 140 

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly
145                 150                 155                 160 

Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His
                165                 170                 175 

Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg
            180                 185                 190 

Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val
        195                 200                 205 

Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg
    210                 215                 220 

Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala
225                 230                 235                 240 

Ala Glu Gly Pro Ser Asp Ile Pro Asp Lys Lys Lys Arg Lys
                245                 250                


<210>    24
<211>    287
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ub7KR(G76A)-MTS-p53-p16-NLS-SABP


<400>    24
Met Gln Ile Phe Val Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu
  1               5                  10                  15 

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp
             20                  25                  30 

Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg
         35                  40                  45 

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu
     50                  55                  60 

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Ala Glu Phe Ala Ala
 65                  70                  75                  80 

Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro Glu Thr
                 85                  90                  95 

Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Lys Leu Met Glu Pro
            100                 105                 110 

Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala Thr Ala
        115                 120                 125 

Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu Ala Gly
    130                 135                 140 

Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln Val
145                 150                 155                 160 

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly
                165                 170                 175 

Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His
            180                 185                 190 

Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg
        195                 200                 205 

Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val
    210                 215                 220 

Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg
225                 230                 235                 240 

Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala
                245                 250                 255 

Ala Glu Gly Pro Ser Asp Ile Pro Asp Lys Lys Lys Arg Lys Gly Gly
            260                 265                 270 

Gly Ser Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp
        275                 280                 285 


