                         SEQUENCE LISTING

<110>  INSERM
 
<120>  NEW ALZHEIMER DISEASE ANIMAL MODEL

<130>  BIO13199 CARTIER

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgcccg gactggctct gctgctgctg gccgcttgga ccgccagagc cctggaagtg     60

cccaccgatg gcaatgctgg cctgctggcc gagccccaga tcgccatgtt ctgcggcaga    120

ctgaacatgc acatgaacgt gcagaacggc aagtgggaca gcgaccccag cggcaccaag    180

acctgcatcg acaccaaaga gggcatcctg cagtattgcc aggaagtgta ccccgagctg    240

cagatcacca acgtggtgga agccaaccag cccgtgacca tccagaactg gtgcaagcgg    300

ggcagaaagc agtgcaagac ccacccccac ttcgtgatcc cttaccggtg cctggtcgga    360

gagttcgtgt ccgacgccct gctggtgccc gacaagtgca agttcctgca tcaggaacgg    420

atggacgtct gcgagacaca tctgcactgg cacaccgtgg ccaaagagac atgcagcgag    480

aagtccacca acctgcacga ctacggcatg ctgctgccct gcggcatcga caagttccgg    540

ggcgtggaat tcgtgtgctg ccccctggcc gaggaatccg acaacgtgga cagcgccgac    600

gccgaagagg acgacagcga cgtgtggtgg ggcggagccg acaccgatta cgccgacggc    660

agcgaggaca aggtcgtgga agtggctgaa gaggaagagg tggccgaggt cgaagaagag    720

gaagccgacg acgacgagga tgacgaggac ggcgacgaag tggaagaaga agccgaggaa    780

ccctacgagg aagccaccga gcggaccacc tctatcgcca ccaccaccac aaccactacc    840

gagagcgtgg aagaggtggt gcgcgaagtg tgcagcgagc aggccgagac aggcccctgc    900

cgggccatga tcagccggtg gtacttcgac gtgaccgagg gcaagtgcgc ccccttcttc    960

tatggcggct gcggcggcaa ccggaacaac ttcgacaccg aggaatactg catggccgtg   1020

tgcggcagcg ccatccctac cacagccgcc agcacccccg acgccgtgga caagtacctg   1080

gaaacccctg gcgacgagaa cgagcacgcc cacttccaga aggccaaaga gcggctggaa   1140

gccaagcacc gcgagcggat gagccaggtg atgagagagt gggaagaggc cgagagacag   1200

gccaagaacc tgcccaaggc cgacaagaaa gccgtgatcc agcacttcca ggaaaaggtc   1260

gaaagcctgg aacaggaagc cgccaacgag cggcagcagc tggtggaaac ccacatggcc   1320

agagtggaag ccatgctgaa cgaccggcgg agactggccc tggaaaacta catcaccgcc   1380

ctgcaggccg tgccccccag acccagacac gtgttcaaca tgctgaagaa atacgtgcgg   1440

gccgagcaga aggaccggca gcacaccctg aagcacttcg agcacgtgcg gatggtggac   1500

cccaagaagg ccgcccagat ccgctctcag gtcatgaccc acctgagagt gatctacgag   1560

agaatgaacc agagcctgag cctgctgtac aatgtgcccg ccgtggccga agaaatccag   1620

gacgaggtgg acgagctgct gcagaaagag cagaactaca gcgacgacgt gctggccaac   1680

atgatcagcg agccccggat cagctacggc aacgacgccc tgatgcccag cctgaccgag   1740

acaaagacca ccgtggaact gctgcccgtg aacggcgagt tcagcctgga cgacctgcag   1800

ccctggcaca gctttggcgc tgatagcgtg cccgccaaca ccgagaacga ggtggaaccc   1860

gtggacgcca gacctgccgc cgacagaggc ctgaccacaa gacctggcag cggcctgacc   1920

aacatcaaga ccgaagagat cagcgaagtg aacctggacg ccgagttccg gcacgacagc   1980

ggctacgagg tgcaccacca gaaactggtg ttcttcgccg aggacgtggg cagcaacaag   2040

ggcgccatca tcggcctgat ggtcggaggc gtggtgatcg ccaccgtgat catcatcacc   2100

ctggtgatgc tgaaaaagaa gcagtacacc agcatccacc acggcgtggt cgaagtggac   2160

gccgctgtga cccccgagga acggcacctg agcaagatgc agcagaacgg ctacgagaac   2220

cccacctaca agttcttcga gcagatgcag aactga                             2256


<210>  2
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Ile Pro Thr Thr Ala Ala Ser Thr 
            340                 345                 350         


Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu 
        355                 360                 365             


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
    370                 375                 380                 


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
385                 390                 395                 400 


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
                405                 410                 415     


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
            420                 425                 430         


Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
        435                 440                 445             


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val 
    450                 455                 460                 


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
465                 470                 475                 480 


Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val 
                485                 490                 495     


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
            500                 505                 510         


Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
        515                 520                 525             


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
    530                 535                 540                 


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
545                 550                 555                 560 


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
                565                 570                 575     


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
            580                 585                 590         


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
        595                 600                 605             


Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
    610                 615                 620                 


Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr 
625                 630                 635                 640 


Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Asn Leu Asp Ala Glu Phe 
                645                 650                 655     


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
            660                 665                 670         


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
        675                 680                 685             


Gly Gly Val Val Ile Ala Thr Val Ile Ile Ile Thr Leu Val Met Leu 
    690                 695                 700                 


Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp 
705                 710                 715                 720 


Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750     


<210>  3
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Ile Pro Thr Thr Ala Ala Ser Thr 
            340                 345                 350         


Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu 
        355                 360                 365             


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
    370                 375                 380                 


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
385                 390                 395                 400 


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
                405                 410                 415     


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
            420                 425                 430         


Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
        435                 440                 445             


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val 
    450                 455                 460                 


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
465                 470                 475                 480 


Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val 
                485                 490                 495     


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
            500                 505                 510         


Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
        515                 520                 525             


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
    530                 535                 540                 


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
545                 550                 555                 560 


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
                565                 570                 575     


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
            580                 585                 590         


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
        595                 600                 605             


Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
    610                 615                 620                 


Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr 
625                 630                 635                 640 


Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
                645                 650                 655     


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
            660                 665                 670         


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
        675                 680                 685             


Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu 
    690                 695                 700                 


Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp 
705                 710                 715                 720 


Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750     


<210>  4
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Leu Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  5
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  6
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Phe 
        275                 280                 285             


Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met Ala 
    290                 295                 300                 


Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp Pro 
305                 310                 315                 320 


Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr Pro 
                325                 330                 335     


Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu Glu 
            340                 345                 350         


Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
        355                 360                 365             


Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp Trp 
    370                 375                 380                 


Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
385                 390                 395                 400 


Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu Pro 
                405                 410                 415     


Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn Leu 
            420                 425                 430         


Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445         


