                         SEQUENCE LISTING

<110>  Conagen
 
<120>  Methods of Using O-Methyltransferase for Biosynthetic Production 
       of Pterostilbene

<130>  515281.12

<140>  PCT
<141>  2014-11-02

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1
cgcgaacaga ttggaggtga tttggcaaac ggtgtgatat cagc                        44


<210>  2
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  2
gtggcggccg ctctattatc aaggataaac ctcaatgagg gacc                        44


<210>  3
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  3
atggatttgg caaacggtgt gatatc                                            26


<210>  4
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
tcaaggataa acctcaatga gggacc                                            26


<210>  5
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
atggcgccac aagaacaagc agtttc                                            26


<210>  6
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
gagggcaaaa ctagcaaatg gattgggatc tggcatggct tcagtcgagg aatttagaa        59


<210>  7
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
ttctaaattc ctcgactgaa gccatgccag atcccaatcc atttgctagt tttgccctc        59


<210>  8
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
ttaatttgta accataggaa tgctatg                                           27


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
cgggatccat ggcgccacaa gaacaagcag tttc                                   34


<210>  10
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
cccaagcttt taatttgtaa ccataggaat gctatg                                 36


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  11
tttttttttt tttttttttt vn                                                22


<210>  12
<211>  1074
<212>  DNA
<213>  Vitis vinifera

<400>  12
atggatttgg caaacggtgt gatatcagct gagctgcttc atgctcaagc tcatgtctgg       60

aatcatatat tcaacttcat aaagtctatg tcactaaaat gtgctattca actaggcatc      120

ccagacatca tccacaacca tggcaagccc atgactcttc ctgagctagt cgctaagctc      180

ccagtccacc ctaaaaggag tcagtgcgtg taccgtctca tgcgcattct tgttcattct      240

ggcttccttg ctgcgcaaag agtccaacaa ggtaaggaag aggaggggta tgtgcttaca      300

gatgcctcta ggctccttct aatggatgac tccttgagca taaggccctt ggtgcttgcc      360

atgctcgacc caattttaac taaaccatgg cattatctga gtgcttggtt tcaaaatgat      420

gatcccactc cgttccacac tgctcatgag cggtcatttt gggattatgc cggccatgaa      480

ccccagctca acaattcctt caatgaagcc atggctagcg atgctcgctt actcaccagc      540

gtgctgctta aggagggcca gggcgtattt gcggggttga actcattagt tgatgtaggg      600

ggtggcaccg gaaaagtggc caaggccatt gctaacgctt tcccacattt gaactgcacc      660

gtgttagatc tcccccacgt ggttgctggc ttgcaaggga gcaagaactt gaactacttt      720

gcaggtgata tgtttgaggc aattcctcct gcagacgcaa ttttactcaa gtggatactg      780

cacgactgga gcgatgaaga atgcgtgaag atactaaagc gatgcaggga agcaattccg      840

agcaaggaaa acggaggaaa ggtgattatc atagacatga tcatgatgaa gaatcaagga      900

gactacaagt ccacagaaac acagctgttc tttgatatga cgatgatgat tttcgccccg      960

ggtagagaga gggacgagaa cgaatgggag aagctattct tggatgctgg tttcagtcac     1020

tacaagataa ctcccatttt gggtttgagg tccctcattg aggtttatcc ttga           1074


<210>  13
<211>  357
<212>  PRT
<213>  Vitis vinifera

<400>  13

Met Asp Leu Ala Asn Gly Val Ile Ser Ala Glu Leu Leu His Ala Gln 
1               5                   10                  15      


Ala His Val Trp Asn His Ile Phe Asn Phe Ile Lys Ser Met Ser Leu 
            20                  25                  30          


Lys Cys Ala Ile Gln Leu Gly Ile Pro Asp Ile Ile His Asn His Gly 
        35                  40                  45              


Lys Pro Met Thr Leu Pro Glu Leu Val Ala Lys Leu Pro Val His Pro 
    50                  55                  60                  


Lys Arg Ser Gln Cys Val Tyr Arg Leu Met Arg Ile Leu Val His Ser 
65                  70                  75                  80  


Gly Phe Leu Ala Ala Gln Arg Val Gln Gln Gly Lys Glu Glu Glu Gly 
                85                  90                  95      


Tyr Val Leu Thr Asp Ala Ser Arg Leu Leu Leu Met Asp Asp Ser Leu 
            100                 105                 110         


Ser Ile Arg Pro Leu Val Leu Ala Met Leu Asp Pro Ile Leu Thr Lys 
        115                 120                 125             


Pro Trp His Tyr Leu Ser Ala Trp Phe Gln Asn Asp Asp Pro Thr Pro 
    130                 135                 140                 


Phe His Thr Ala His Glu Arg Ser Phe Trp Asp Tyr Ala Gly His Glu 
145                 150                 155                 160 


Pro Gln Leu Asn Asn Ser Phe Asn Glu Ala Met Ala Ser Asp Ala Arg 
                165                 170                 175     


Leu Leu Thr Ser Val Leu Leu Lys Glu Gly Gln Gly Val Phe Ala Gly 
            180                 185                 190         


Leu Asn Ser Leu Val Asp Val Gly Gly Gly Thr Gly Lys Val Ala Lys 
        195                 200                 205             


Ala Ile Ala Asn Ala Phe Pro His Leu Asn Cys Thr Val Leu Asp Leu 
    210                 215                 220                 


Pro His Val Val Ala Gly Leu Gln Gly Ser Lys Asn Leu Asn Tyr Phe 
225                 230                 235                 240 


Ala Gly Asp Met Phe Glu Ala Ile Pro Pro Ala Asp Ala Ile Leu Leu 
                245                 250                 255     


Lys Trp Ile Leu His Asp Trp Ser Asp Glu Glu Cys Val Lys Ile Leu 
            260                 265                 270         


Lys Arg Cys Arg Glu Ala Ile Pro Ser Lys Glu Asn Gly Gly Lys Val 
        275                 280                 285             


Ile Ile Ile Asp Met Ile Met Met Lys Asn Gln Gly Asp Tyr Lys Ser 
    290                 295                 300                 


Thr Glu Thr Gln Leu Phe Phe Asp Met Thr Met Met Ile Phe Ala Pro 
305                 310                 315                 320 


Gly Arg Glu Arg Asp Glu Asn Glu Trp Glu Lys Leu Phe Leu Asp Ala 
                325                 330                 335     


Gly Phe Ser His Tyr Lys Ile Thr Pro Ile Leu Gly Leu Arg Ser Leu 
            340                 345                 350         


Ile Glu Val Tyr Pro 
        355         


<210>  14
<211>  1686
<212>  DNA
<213>  Arabidopsis thaliana

<400>  14
atggcgccac aagaacaagc agtttctcag gtgatggaga aacagagcaa caacaacaac       60

agtgacgtca ttttccgatc aaagttaccg gatatttaca tcccgaacca cctatctctc      120

cacgactaca tcttccaaaa catctccgaa ttcgccacta agccttgcct aatcaacgga      180

ccaaccggcc acgtgtacac ttactccgac gtccacgtca tctcccgcca aatcgccgcc      240

aattttcaca aactcggcgt taaccaaaac gacgtcgtca tgctcctcct cccaaactgt      300

cccgaattcg tcctctcttt cctcgccgcc tccttccgcg gcgcaaccgc caccgccgca      360

aaccctttct tcactccggc ggagatagct aaacaagcca aagcctccaa caccaaactc      420

ataatcaccg aagctcgtta cgtcgacaaa atcaaaccac ttcaaaacga cgacggagta      480

gtcatcgtct gcatcgacga caacgaatcc gtgccaatcc ctgaaggctg cctccgcttc      540

accgagttga ctcagtcgac aaccgaggca tcagaagtca tcgactcggt ggagatttca      600

ccggacgacg tggtggcact accttactcc tctggcacga cgggattacc aaaaggagtg      660

atgctgactc acaagggact agtcacgagc gttgctcagc aagtcgacgg cgagaacccg      720

aatctttatt tccacagcga tgacgtcata ctctgtgttt tgcccatgtt tcatatctac      780

gctttgaact cgatcatgtt gtgtggtctt agagttggtg cggcgattct gataatgccg      840

aagtttgaga tcaatctgct attggagctg atccagaggt gtaaagtgac ggtggctccg      900

atggttccgc cgattgtgtt ggccattgcg aagtcttcgg agacggagaa gtatgatttg      960

agctcgataa gagtggtgaa atctggtgct gctcctcttg gtaaagaact tgaagatgcc     1020

gttaatgcca agtttcctaa tgccaaactc ggtcagggat acggaatgac ggaagcaggt     1080

ccagtgctag caatgtcgtt aggttttgca aaggaacctt ttccggttaa gtcaggagct     1140

tgtggtactg ttgtaagaaa tgctgagatg aaaatagttg atccagacac cggagattct     1200

ctttcgagga atcaacccgg tgagatttgt attcgtggtc accagatcat gaaaggttac     1260

ctcaacaatc cggcagctac agcagagacc attgataaag acggttggct tcatactgga     1320

gatattggat tgatcgatga cgatgacgag cttttcatcg ttgatcgatt gaaagaactt     1380

atcaagtata aaggttttca ggtagctccg gctgagctag aggctttgct catcggtcat     1440

cctgacatta ctgatgttgc tgttgtcgca atgaaagaag aagcagctgg tgaagttcct     1500

gttgcatttg tggtgaaatc gaaggattcg gagttatcag aagatgatgt gaagcaattc     1560

gtgtcgaaac aggttgtgtt ttacaagaga atcaacaaag tgttcttcac tgaatccatt     1620

cctaaagctc catcagggaa gatattgagg aaagatctga gggcaaaact agcaaatgga     1680

ttgtga                                                                1686


<210>  15
<211>  561
<212>  PRT
<213>  Arabidopsis thaliana

<400>  15

Met Ala Pro Gln Glu Gln Ala Val Ser Gln Val Met Glu Lys Gln Ser 
1               5                   10                  15      


Asn Asn Asn Asn Ser Asp Val Ile Phe Arg Ser Lys Leu Pro Asp Ile 
            20                  25                  30          


Tyr Ile Pro Asn His Leu Ser Leu His Asp Tyr Ile Phe Gln Asn Ile 
        35                  40                  45              


Ser Glu Phe Ala Thr Lys Pro Cys Leu Ile Asn Gly Pro Thr Gly His 
    50                  55                  60                  


Val Tyr Thr Tyr Ser Asp Val His Val Ile Ser Arg Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Phe His Lys Leu Gly Val Asn Gln Asn Asp Val Val Met Leu Leu 
                85                  90                  95      


Leu Pro Asn Cys Pro Glu Phe Val Leu Ser Phe Leu Ala Ala Ser Phe 
            100                 105                 110         


Arg Gly Ala Thr Ala Thr Ala Ala Asn Pro Phe Phe Thr Pro Ala Glu 
        115                 120                 125             


Ile Ala Lys Gln Ala Lys Ala Ser Asn Thr Lys Leu Ile Ile Thr Glu 
    130                 135                 140                 


Ala Arg Tyr Val Asp Lys Ile Lys Pro Leu Gln Asn Asp Asp Gly Val 
145                 150                 155                 160 


Val Ile Val Cys Ile Asp Asp Asn Glu Ser Val Pro Ile Pro Glu Gly 
                165                 170                 175     


Cys Leu Arg Phe Thr Glu Leu Thr Gln Ser Thr Thr Glu Ala Ser Glu 
            180                 185                 190         


Val Ile Asp Ser Val Glu Ile Ser Pro Asp Asp Val Val Ala Leu Pro 
        195                 200                 205             


Tyr Ser Ser Gly Thr Thr Gly Leu Pro Lys Gly Val Met Leu Thr His 
    210                 215                 220                 


Lys Gly Leu Val Thr Ser Val Ala Gln Gln Val Asp Gly Glu Asn Pro 
225                 230                 235                 240 


Asn Leu Tyr Phe His Ser Asp Asp Val Ile Leu Cys Val Leu Pro Met 
                245                 250                 255     


Phe His Ile Tyr Ala Leu Asn Ser Ile Met Leu Cys Gly Leu Arg Val 
            260                 265                 270         


Gly Ala Ala Ile Leu Ile Met Pro Lys Phe Glu Ile Asn Leu Leu Leu 
        275                 280                 285             


Glu Leu Ile Gln Arg Cys Lys Val Thr Val Ala Pro Met Val Pro Pro 
    290                 295                 300                 


Ile Val Leu Ala Ile Ala Lys Ser Ser Glu Thr Glu Lys Tyr Asp Leu 
305                 310                 315                 320 


Ser Ser Ile Arg Val Val Lys Ser Gly Ala Ala Pro Leu Gly Lys Glu 
                325                 330                 335     


Leu Glu Asp Ala Val Asn Ala Lys Phe Pro Asn Ala Lys Leu Gly Gln 
            340                 345                 350         


Gly Tyr Gly Met Thr Glu Ala Gly Pro Val Leu Ala Met Ser Leu Gly 
        355                 360                 365             


Phe Ala Lys Glu Pro Phe Pro Val Lys Ser Gly Ala Cys Gly Thr Val 
    370                 375                 380                 


Val Arg Asn Ala Glu Met Lys Ile Val Asp Pro Asp Thr Gly Asp Ser 
385                 390                 395                 400 


Leu Ser Arg Asn Gln Pro Gly Glu Ile Cys Ile Arg Gly His Gln Ile 
                405                 410                 415     


Met Lys Gly Tyr Leu Asn Asn Pro Ala Ala Thr Ala Glu Thr Ile Asp 
            420                 425                 430         


Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Leu Ile Asp Asp Asp 
        435                 440                 445             


Asp Glu Leu Phe Ile Val Asp Arg Leu Lys Glu Leu Ile Lys Tyr Lys 
    450                 455                 460                 


Gly Phe Gln Val Ala Pro Ala Glu Leu Glu Ala Leu Leu Ile Gly His 
465                 470                 475                 480 


Pro Asp Ile Thr Asp Val Ala Val Val Ala Met Lys Glu Glu Ala Ala 
                485                 490                 495     


Gly Glu Val Pro Val Ala Phe Val Val Lys Ser Lys Asp Ser Glu Leu 
            500                 505                 510         


Ser Glu Asp Asp Val Lys Gln Phe Val Ser Lys Gln Val Val Phe Tyr 
        515                 520                 525             


Lys Arg Ile Asn Lys Val Phe Phe Thr Glu Ser Ile Pro Lys Ala Pro 
    530                 535                 540                 


Ser Gly Lys Ile Leu Arg Lys Asp Leu Arg Ala Lys Leu Ala Asn Gly 
545                 550                 555                 560 


Leu 
    


<210>  16
<211>  1179
<212>  DNA
<213>  Vitis vinifera

<400>  16
atggcttcag tcgaggaatt tagaaacgct caacgtgcca agggtccggc caccatccta       60

gccattggca cagctacccc cgaccactgt gtctaccagt ctgattatgc tgattactat      120

ttcaaggtca ctaagagcga gcacatgact gcgttgaaga agaagttcaa tcgcatatgt      180

gacaaatcca tgatcaagaa gcgttacatt catttgaccg aagaaatgct tgaggagcac      240

ccaaacattg gtgcttatat ggctccatct cttaacatac gccaagagat tatcactgct      300

gaggtaccca agctcggtaa ggaagcagca ttgaaggctc ttaaagagtg gggtcagcct      360

aaatcgaaga tcacccacct tgtattttgt accacctcag gtgtagaaat gcctggtgca      420

gattataaac tcgctaatct tttaggcctc gaaccatctg tcagaagagt gatgttgtac      480

catcaagggt gctatgcagg tggaactgtc cttcgaaccg ctaaggatct tgcagagaat      540

aatgcaggag cacgagttct tgtggtgtgc tctgagatca cagttgttac atttcgcggc      600

ccttccgaag atgctttgga ctctttagtt ggccaagccc tttttggtga tggttctgca      660

gctgtaatcg taggatcaga tccggatatc tcaattgaac gaccactctt ccagcttgtc      720

tcagcagccc aaacatttat tcctaattct gcaggtgcca ttgcaggaaa cttacgtgag      780

gtgggactca cctttcattt gtggcccaat gtgcccactt taatttctga gaacgtagag      840

aaatgtttga ctcaggcttt tgacccactt ggtattagcg attggaactc gttattttgg      900

attgctcacc caggtggccc tgcaattctt gatgcagttg aagcaaaact caatttagat      960

aaaaagaaac tcgaagcaac gaggcatgtg ttaagtgagt atggaaacat gtcaagtgca     1020

tgtgtgttgt ttattttgga tgagatgaga aagaaatccc ttaaggggga gagggccacc     1080

acgggtgaag gattggattg gggagtatta ttcggttttg gaccaggctt gactattgaa     1140

actgttgtgt tgcatagcat tcctatggtt acaaattaa                            1179


<210>  17
<211>  392
<212>  PRT
<213>  Vitis vinifera

<400>  17

Met Ala Ser Val Glu Glu Phe Arg Asn Ala Gln Arg Ala Lys Gly Pro 
1               5                   10                  15      


Ala Thr Ile Leu Ala Ile Gly Thr Ala Thr Pro Asp His Cys Val Tyr 
            20                  25                  30          


Gln Ser Asp Tyr Ala Asp Tyr Tyr Phe Lys Val Thr Lys Ser Glu His 
        35                  40                  45              


Met Thr Ala Leu Lys Lys Lys Phe Asn Arg Ile Cys Asp Lys Ser Met 
    50                  55                  60                  


Ile Lys Lys Arg Tyr Ile His Leu Thr Glu Glu Met Leu Glu Glu His 
65                  70                  75                  80  


Pro Asn Ile Gly Ala Tyr Met Ala Pro Ser Leu Asn Ile Arg Gln Glu 
                85                  90                  95      


Ile Ile Thr Ala Glu Val Pro Lys Leu Gly Lys Glu Ala Ala Leu Lys 
            100                 105                 110         


Ala Leu Lys Glu Trp Gly Gln Pro Lys Ser Lys Ile Thr His Leu Val 
        115                 120                 125             


Phe Cys Thr Thr Ser Gly Val Glu Met Pro Gly Ala Asp Tyr Lys Leu 
    130                 135                 140                 


Ala Asn Leu Leu Gly Leu Glu Pro Ser Val Arg Arg Val Met Leu Tyr 
145                 150                 155                 160 


His Gln Gly Cys Tyr Ala Gly Gly Thr Val Leu Arg Thr Ala Lys Asp 
                165                 170                 175     


Leu Ala Glu Asn Asn Ala Gly Ala Arg Val Leu Val Val Cys Ser Glu 
            180                 185                 190         


Ile Thr Val Val Thr Phe Arg Gly Pro Ser Glu Asp Ala Leu Asp Ser 
        195                 200                 205             


Leu Val Gly Gln Ala Leu Phe Gly Asp Gly Ser Ala Ala Val Ile Val 
    210                 215                 220                 


Gly Ser Asp Pro Asp Ile Ser Ile Glu Arg Pro Leu Phe Gln Leu Val 
225                 230                 235                 240 


Ser Ala Ala Gln Thr Phe Ile Pro Asn Ser Ala Gly Ala Ile Ala Gly 
                245                 250                 255     


Asn Leu Arg Glu Val Gly Leu Thr Phe His Leu Trp Pro Asn Val Pro 
            260                 265                 270         


Thr Leu Ile Ser Glu Asn Val Glu Lys Cys Leu Thr Gln Ala Phe Asp 
        275                 280                 285             


Pro Leu Gly Ile Ser Asp Trp Asn Ser Leu Phe Trp Ile Ala His Pro 
    290                 295                 300                 


Gly Gly Pro Ala Ile Leu Asp Ala Val Glu Ala Lys Leu Asn Leu Asp 
305                 310                 315                 320 


Lys Lys Lys Leu Glu Ala Thr Arg His Val Leu Ser Glu Tyr Gly Asn 
                325                 330                 335     


Met Ser Ser Ala Cys Val Leu Phe Ile Leu Asp Glu Met Arg Lys Lys 
            340                 345                 350         


Ser Leu Lys Gly Glu Arg Ala Thr Thr Gly Glu Gly Leu Asp Trp Gly 
        355                 360                 365             


Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Ile Glu Thr Val Val Leu 
    370                 375                 380                 


His Ser Ile Pro Met Val Thr Asn 
385                 390         


<210>  18
<211>  2871
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion gene

<400>  18
atggcgccac aagaacaagc agtttctcag gtgatggaga aacagagcaa caacaacaac       60

agtgacgtca ttttccgatc aaagttaccg gatatttaca tcccgaacca cctatctctc      120

cacgactaca tcttccaaaa catctccgaa ttcgccacta agccttgcct aatcaacgga      180

ccaaccggcc acgtgtacac ttactccgac gtccacgtca tctcccgcca aatcgccgcc      240

aattttcaca aactcggcgt taaccaaaac gacgtcgtca tgctcctcct cccaaactgt      300

cccgaattcg tcctctcttt cctcgccgcc tccttccgcg gcgcaaccgc caccgccgca      360

aaccctttct tcactccggc ggagatagct aaacaagcca aagcctccaa caccaaactc      420

ataatcaccg aagctcgtta cgtcgacaaa atcaaaccac ttcaaaacga cgacggagta      480

gtcatcgtct gcatcgacga caacgaatcc gtgccaatcc ctgaaggctg cctccgcttc      540

accgagttga ctcagtcgac aaccgaggca tcagaagtca tcgactcggt ggagatttca      600

ccggacgacg tggtggcact accttactcc tctggcacga cgggattacc aaaaggagtg      660

atgctgactc acaagggact agtcacgagc gttgctcagc aagtcgacgg cgagaacccg      720

aatctttatt tccacagcga tgacgtcata ctctgtgttt tgcccatgtt tcatatctac      780

gctttgaact cgatcatgtt gtgtggtctt agagttggtg cggcgattct gataatgccg      840

aagtttgaga tcaatctgct attggagctg atccagaggt gtaaagtgac ggtggctccg      900

atggttccgc cgattgtgtt ggccattgcg aagtcttcgg agacggagaa gtatgatttg      960

agctcgataa gagtggtgaa atctggtgct gctcctcttg gtaaagaact tgaagatgcc     1020

gttaatgcca agtttcctaa tgccaaactc ggtcagggat acggaatgac ggaagcaggt     1080

ccagtgctag caatgtcgtt aggttttgca aaggaacctt ttccggttaa gtcaggagct     1140

tgtggtactg ttgtaagaaa tgctgagatg aaaatagttg atccagacac cggagattct     1200

ctttcgagga atcaacccgg tgagatttgt attcgtggtc accagatcat gaaaggttac     1260

ctcaacaatc cggcagctac agcagagacc attgataaag acggttggct tcatactgga     1320

gatattggat tgatcgatga cgatgacgag cttttcatcg ttgatcgatt gaaagaactt     1380

atcaagtata aaggttttca ggtagctccg gctgagctag aggctttgct catcggtcat     1440

cctgacatta ctgatgttgc tgttgtcgca atgaaagaag aagcagctgg tgaagttcct     1500

gttgcatttg tggtgaaatc gaaggattcg gagttatcag aagatgatgt gaagcaattc     1560

gtgtcgaaac aggttgtgtt ttacaagaga atcaacaaag tgttcttcac tgaatccatt     1620

cctaaagctc catcagggaa gatattgagg aaagatctga gggcaaaact agcaaatgga     1680

ttgggatctg gcatggcttc agtcgaggaa tttagaaacg ctcaacgtgc caagggtccg     1740

gccaccatcc tagccattgg cacagctacc cccgaccact gtgtctacca gtctgattat     1800

gctgattact atttcaaggt cactaagagc gagcacatga ctgcgttgaa gaagaagttc     1860

aatcgcatat gtgacaaatc catgatcaag aagcgttaca ttcatttgac cgaagaaatg     1920

cttgaggagc acccaaacat tggtgcttat atggctccat ctcttaacat acgccaagag     1980

attatcactg ctgaggtacc caagctcggt aaggaagcag cattgaaggc tcttaaagag     2040

tggggtcagc ctaaatcgaa gatcacccac cttgtatttt gtaccacctc aggtgtagaa     2100

atgcctggtg cagattataa actcgctaat cttttaggcc tcgaaccatc tgtcagaaga     2160

gtgatgttgt accatcaagg gtgctatgca ggtggaactg tccttcgaac cgctaaggat     2220

cttgcagaga ataatgcagg agcacgagtt cttgtggtgt gctctgagat cacagttgtt     2280

acatttcgcg gcccttccga agatgctttg gactctttag ttggccaagc cctttttggt     2340

gatggttctg cagctgtaat cgtaggatca gatccggata tctcaattga acgaccactc     2400

ttccagcttg tctcagcagc ccaaacattt attcctaatt ctgcaggtgc cattgcagga     2460

aacttacgtg aggtgggact cacctttcat ttgtggccca atgtgcccac tttaatttct     2520

gagaacgtag agaaatgttt gactcaggct tttgacccac ttggtattag cgattggaac     2580

tcgttatttt ggattgctca cccaggtggc cctgcaattc ttgatgcagt tgaagcaaaa     2640

ctcaatttag ataaaaagaa actcgaagca acgaggcatg tgttaagtga gtatggaaac     2700

atgtcaagtg catgtgtgtt gtttattttg gatgagatga gaaagaaatc ccttaagggg     2760

gagagggcca ccacgggtga aggattggat tggggagtat tattcggttt tggaccaggc     2820

ttgactattg aaactgttgt gttgcatagc attcctatgg ttacaaatta a              2871


<210>  19
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  19

Met Ala Pro Gln Glu Gln Ala Val Ser Gln Val Met Glu Lys Gln Ser 
1               5                   10                  15      


Asn Asn Asn Asn Ser Asp Val Ile Phe Arg Ser Lys Leu Pro Asp Ile 
            20                  25                  30          


Tyr Ile Pro Asn His Leu Ser Leu His Asp Tyr Ile Phe Gln Asn Ile 
        35                  40                  45              


Ser Glu Phe Ala Thr Lys Pro Cys Leu Ile Asn Gly Pro Thr Gly His 
    50                  55                  60                  


Val Tyr Thr Tyr Ser Asp Val His Val Ile Ser Arg Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Phe His Lys Leu Gly Val Asn Gln Asn Asp Val Val Met Leu Leu 
                85                  90                  95      


Leu Pro Asn Cys Pro Glu Phe Val Leu Ser Phe Leu Ala Ala Ser Phe 
            100                 105                 110         


Arg Gly Ala Thr Ala Thr Ala Ala Asn Pro Phe Phe Thr Pro Ala Glu 
        115                 120                 125             


Ile Ala Lys Gln Ala Lys Ala Ser Asn Thr Lys Leu Ile Ile Thr Glu 
    130                 135                 140                 


Ala Arg Tyr Val Asp Lys Ile Lys Pro Leu Gln Asn Asp Asp Gly Val 
145                 150                 155                 160 


Val Ile Val Cys Ile Asp Asp Asn Glu Ser Val Pro Ile Pro Glu Gly 
                165                 170                 175     


Cys Leu Arg Phe Thr Glu Leu Thr Gln Ser Thr Thr Glu Ala Ser Glu 
            180                 185                 190         


Val Ile Asp Ser Val Glu Ile Ser Pro Asp Asp Val Val Ala Leu Pro 
        195                 200                 205             


Tyr Ser Ser Gly Thr Thr Gly Leu Pro Lys Gly Val Met Leu Thr His 
    210                 215                 220                 


Lys Gly Leu Val Thr Ser Val Ala Gln Gln Val Asp Gly Glu Asn Pro 
225                 230                 235                 240 


Asn Leu Tyr Phe His Ser Asp Asp Val Ile Leu Cys Val Leu Pro Met 
                245                 250                 255     


Phe His Ile Tyr Ala Leu Asn Ser Ile Met Leu Cys Gly Leu Arg Val 
            260                 265                 270         


Gly Ala Ala Ile Leu Ile Met Pro Lys Phe Glu Ile Asn Leu Leu Leu 
        275                 280                 285             


Glu Leu Ile Gln Arg Cys Lys Val Thr Val Ala Pro Met Val Pro Pro 
    290                 295                 300                 


Ile Val Leu Ala Ile Ala Lys Ser Ser Glu Thr Glu Lys Tyr Asp Leu 
305                 310                 315                 320 


Ser Ser Ile Arg Val Val Lys Ser Gly Ala Ala Pro Leu Gly Lys Glu 
                325                 330                 335     


Leu Glu Asp Ala Val Asn Ala Lys Phe Pro Asn Ala Lys Leu Gly Gln 
            340                 345                 350         


Gly Tyr Gly Met Thr Glu Ala Gly Pro Val Leu Ala Met Ser Leu Gly 
        355                 360                 365             


Phe Ala Lys Glu Pro Phe Pro Val Lys Ser Gly Ala Cys Gly Thr Val 
    370                 375                 380                 


Val Arg Asn Ala Glu Met Lys Ile Val Asp Pro Asp Thr Gly Asp Ser 
385                 390                 395                 400 


Leu Ser Arg Asn Gln Pro Gly Glu Ile Cys Ile Arg Gly His Gln Ile 
                405                 410                 415     


Met Lys Gly Tyr Leu Asn Asn Pro Ala Ala Thr Ala Glu Thr Ile Asp 
            420                 425                 430         


Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Leu Ile Asp Asp Asp 
        435                 440                 445             


Asp Glu Leu Phe Ile Val Asp Arg Leu Lys Glu Leu Ile Lys Tyr Lys 
    450                 455                 460                 


Gly Phe Gln Val Ala Pro Ala Glu Leu Glu Ala Leu Leu Ile Gly His 
465                 470                 475                 480 


Pro Asp Ile Thr Asp Val Ala Val Val Ala Met Lys Glu Glu Ala Ala 
                485                 490                 495     


Gly Glu Val Pro Val Ala Phe Val Val Lys Ser Lys Asp Ser Glu Leu 
            500                 505                 510         


Ser Glu Asp Asp Val Lys Gln Phe Val Ser Lys Gln Val Val Phe Tyr 
        515                 520                 525             


Lys Arg Ile Asn Lys Val Phe Phe Thr Glu Ser Ile Pro Lys Ala Pro 
    530                 535                 540                 


Ser Gly Lys Ile Leu Arg Lys Asp Leu Arg Ala Lys Leu Ala Asn Gly 
545                 550                 555                 560 


Leu Gly Ser Gly Met Ala Ser Val Glu Glu Phe Arg Asn Ala Gln Arg 
                565                 570                 575     


Ala Lys Gly Pro Ala Thr Ile Leu Ala Ile Gly Thr Ala Thr Pro Asp 
            580                 585                 590         


His Cys Val Tyr Gln Ser Asp Tyr Ala Asp Tyr Tyr Phe Lys Val Thr 
        595                 600                 605             


Lys Ser Glu His Met Thr Ala Leu Lys Lys Lys Phe Asn Arg Ile Cys 
    610                 615                 620                 


Asp Lys Ser Met Ile Lys Lys Arg Tyr Ile His Leu Thr Glu Glu Met 
625                 630                 635                 640 


Leu Glu Glu His Pro Asn Ile Gly Ala Tyr Met Ala Pro Ser Leu Asn 
                645                 650                 655     


Ile Arg Gln Glu Ile Ile Thr Ala Glu Val Pro Lys Leu Gly Lys Glu 
            660                 665                 670         


Ala Ala Leu Lys Ala Leu Lys Glu Trp Gly Gln Pro Lys Ser Lys Ile 
        675                 680                 685             


Thr His Leu Val Phe Cys Thr Thr Ser Gly Val Glu Met Pro Gly Ala 
    690                 695                 700                 


Asp Tyr Lys Leu Ala Asn Leu Leu Gly Leu Glu Pro Ser Val Arg Arg 
705                 710                 715                 720 


Val Met Leu Tyr His Gln Gly Cys Tyr Ala Gly Gly Thr Val Leu Arg 
                725                 730                 735     


Thr Ala Lys Asp Leu Ala Glu Asn Asn Ala Gly Ala Arg Val Leu Val 
            740                 745                 750         


Val Cys Ser Glu Ile Thr Val Val Thr Phe Arg Gly Pro Ser Glu Asp 
        755                 760                 765             


Ala Leu Asp Ser Leu Val Gly Gln Ala Leu Phe Gly Asp Gly Ser Ala 
    770                 775                 780                 


Ala Val Ile Val Gly Ser Asp Pro Asp Ile Ser Ile Glu Arg Pro Leu 
785                 790                 795                 800 


Phe Gln Leu Val Ser Ala Ala Gln Thr Phe Ile Pro Asn Ser Ala Gly 
                805                 810                 815     


Ala Ile Ala Gly Asn Leu Arg Glu Val Gly Leu Thr Phe His Leu Trp 
            820                 825                 830         


Pro Asn Val Pro Thr Leu Ile Ser Glu Asn Val Glu Lys Cys Leu Thr 
        835                 840                 845             


Gln Ala Phe Asp Pro Leu Gly Ile Ser Asp Trp Asn Ser Leu Phe Trp 
    850                 855                 860                 


Ile Ala His Pro Gly Gly Pro Ala Ile Leu Asp Ala Val Glu Ala Lys 
865                 870                 875                 880 


Leu Asn Leu Asp Lys Lys Lys Leu Glu Ala Thr Arg His Val Leu Ser 
                885                 890                 895     


Glu Tyr Gly Asn Met Ser Ser Ala Cys Val Leu Phe Ile Leu Asp Glu 
            900                 905                 910         


Met Arg Lys Lys Ser Leu Lys Gly Glu Arg Ala Thr Thr Gly Glu Gly 
        915                 920                 925             


Leu Asp Trp Gly Val Leu Phe Gly Phe Gly Pro Gly Leu Thr Ile Glu 
    930                 935                 940                 


Thr Val Val Leu His Ser Ile Pro Met Val Thr Asn 
945                 950                 955     


