                         SEQUENCE LISTING

<110>  FOUNDATION MEDICINE, INC.
       MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120>  METHODS OF TREATING POST-MYELOPROLIFERATIVE NEOPLASMS (MPNs) AND 
       POST-MPN ACUTE MYELOID LEUKEMIA

<130>  F2036-7051WO

<150>  US 61/898,807
<151>  2013-11-01

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  2
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  2
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggcct gccgcatgac tcgtggttcg       60

gaggcccacg tggccggggc ggggactcag gcgcctgggg cgccgactga ttacgtagcg      120

ggcggggccg gaagtgccgc tccttggtgg gggctgttca tggcggttcc ggggtctcca      180

acatttttcc cggctgtggt cctaaatctg tccaaagcag aggcagtgga gcttgaggtt      240

cttgctggtg tgaaatgact gagtacaaac tggtggtggt tggagcaggt ggtgttggga      300

aaagcgcact gacaatccag ctaatccaga accactttgt agatgaatat gatcccacca      360

tagaggattc ttacagaaaa caagtggtta tagatggtga aacctgtttg ttggacatac      420

tggatacagc tggacaagaa gagtacagtg ccatgagaga ccaatacatg aggacaggcg      480

aaggcttcct ctgtgtattt gccatcaata atagcaagtc atttgcggat attaacctct      540

acagggagca gattaagcga gtaaaagact cggatgatgt acctatggtg ctagtgggaa      600

acaagtgtga tttgccaaca aggacagttg atacaaaaca agcccacgaa ctggccaaga      660

gttacgggat tccattcatt gaaacctcag ccaagaccag acagggtgtt gaagatgctt      720

tttacacact ggtaagagaa atacgccagt accgaatgaa aaaactcaac agcagtgatg      780

atgggactca gggttgtatg ggattgccat gtgtggtgat gtaacaagat acttttaaag      840

ttttgtcaga aaagagccac tttcaagctg cactgacacc ctggtcctga cttccctgga      900

ggagaagtat tcctgttgct gtcttcagtc tcacagagaa gctcctgcta cttccccagc      960

tctcagtagt ttagtacaat aatctctatt tgagaagttc tcagaataac tacctcctca     1020

cttggctgtc tgaccagaga atgcacctct tgttactccc tgttattttt ctgccctggg     1080

ttcttccaca gcacaaacac acctctgcca ccccaggttt ttcatctgaa aagcagttca     1140

tgtctgaaac agagaaccaa accgcaaacg tgaaattcta ttgaaaacag tgtcttgagc     1200

tctaaagtag caactgctgg tgattttttt tttcttttta ctgttgaact tagaactatg     1260

ctaatttttg gagaaatgtc ataaattact gttttgccaa gaatatagtt attattgctg     1320

tttggtttgt ttataatgtt atcggctcta ttctctaaac tggcatctgc tctagattca     1380

taaatacaaa aatgaatact gaattttgag tctatcctag tcttcacaac tttgacgtaa     1440

ttaaatccaa ctttcacagt gaagtgcctt tttcctagaa gtggtttgta gacttccttt     1500

ataatatttc agtggaatag atgtctcaaa aatccttatg catgaaatga atgtctgaga     1560

tacgtctgtg acttatctac cattgaagga aagctatatc tatttgagag cagatgccat     1620

tttgtacatg tatgaaattg gttttccaga ggcctgtttt ggggctttcc caggagaaag     1680

atgaaactga aagcacatga ataatttcac ttaataattt ttacctaatc tccacttttt     1740

tcataggtta ctacctatac aatgtatgta atttgtttcc cctagcttac tgataaacct     1800

aatattcaat gaacttccat ttgtattcaa atttgtgtca taccagaaag ctctacattt     1860

gcagatgttc aaatattgta aaactttggt gcattgttat ttaatagctg tgatcagtga     1920

ttttcaaacc tcaaatatag tatattaaca aattacattt tcactgtata tcatggtatc     1980

ttaatgatgt atataattgc cttcaatccc cttctcaccc caccctctac agcttccccc     2040

acagcaatag gggcttgatt atttcagttg agtaaagcat ggtgctaatg gaccagggtc     2100

acagtttcaa aacttgaaca atccagttag catcacagag aaagaaattc ttctgcattt     2160

gctcattgca ccagtaactc cagctagtaa ttttgctagg tagctgcagt tagccctgca     2220

aggaaagaag aggtcagtta gcacaaaccc tttaccatga ctggaaaact cagtatcacg     2280

tatttaaaca tttttttttc ttttagccat gtagaaactc taaattaagc caatattctc     2340

atttgagaat gaggatgtct cagctgagaa acgttttaaa ttctctttat tcataatgtt     2400

ctttgaaggg tttaaaacaa gatgttgata aatctaagct gatgagtttg ctcaaaacag     2460

gaagttgaaa ttgttgagac aggaatggaa aatataatta attgatacct atgaggattt     2520

ggaggcttgg cattttaatt tgcagataat accctggtaa ttctcatgaa aaatagactt     2580

ggataacttt tgataaaaga ctaattccaa aatggccact ttgttcctgt ctttaatatc     2640

taaatactta ctgaggtcct ccatcttcta tattatgaat tttcatttat taagcaaatg     2700

tcatattacc ttgaaattca gaagagaaga aacatatact gtgtccagag tataatgaac     2760

ctgcagagtt gtgcttctta ctgctaattc tgggagcttt cacagtactg tcatcatttg     2820

taaatggaaa ttctgctttt ctgtttctgc tccttctgga gcagtgctac tctgtaattt     2880

tcctgaggct tatcacctca gtcatttctt ttttaaatgt ctgtgactgg cagtgattct     2940

ttttcttaaa aatctattaa atttgatgtc aaattaggga gaaagatagt tactcatctt     3000

gggctcttgt gccaatagcc cttgtatgta tgtacttaga gttttccaag tatgttctaa     3060

gcacagaagt ttctaaatgg ggccaaaatt cagacttgag tatgttcttt gaatacctta     3120

agaagttaca attagccggg catggtggcc cgtgcctgta gtcccagcta cttgagaggc     3180

tgaggcagga gaatcacttc aacccaggag gtggaggtta cagtgagcag agatcgtgcc     3240

actgcactcc agcctgggtg acaagagaga cttgtctcca aaaaaaaagt tacacctagg     3300

tgtgaatttt ggcacaaagg agtgacaaac ttatagttaa aagctgaata acttcagtgt     3360

ggtataaaac gtggttttta ggctatgttt gtgattgctg aaaagaattc tagtttacct     3420

caaaatcctt ctctttcccc aaattaagtg cctggccagc tgtcataaat tacatattcc     3480

ttttggtttt tttaaaggtt acatgttcaa gagtgaaaat aagatgttct gtctgaaggc     3540

taccatgccg gatctgtaaa tgaacctgtt aaatgctgta tttgctccaa cggcttacta     3600

tagaatgtta cttaatacaa tatcatactt attacaattt ttactatagg agtgtaatag     3660

gtaaaattaa tctctatttt agtgggccca tgtttagtct ttcaccatcc tttaaactgc     3720

tgtgaatttt tttgtcatga cttgaaagca aggatagaga aacactttag agatatgtgg     3780

ggttttttta ccattccaga gcttgtgagc ataatcatat ttgctttata tttatagtca     3840

tgaactccta agttggcagc tacaaccaag aaccaaaaaa tggtgcgttc tgcttcttgt     3900

aattcatctc tgctaataaa ttataagaag caaggaaaat tagggaaaat attttatttg     3960

gatggtttct ataaacaagg gactataatt cttgtacatt atttttcatc tttgctgttt     4020

ctttgagcag tctaatgtgc cacacaatta tctaaggtat ttgttttcta taagaattgt     4080

tttaaaagta ttcttgttac cagagtagtt gtattatatt tcaaaacgta agatgatttt     4140

taaaagcctg agtactgacc taagatggaa ttgtatgaac tctgctctgg agggagggga     4200

ggatgtccgt ggaagttgta agacttttat ttttttgtgc catcaaatat aggtaaaaat     4260

aattgtgcaa ttctgctgtt taaacaggaa ctattggcct ccttggccct aaatggaagg     4320

gccgatattt taagttgatt attttattgt aaattaatcc aacctagttc tttttaattt     4380

ggttgaatgt tttttcttgt taaatgatgt ttaaaaaata aaaactggaa gttcttggct     4440

tagtcataat tctt                                                       4454


