                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Damelin, Marc
 
<120>  ANTI-EFNA4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES

<130>  PC72005

<160>  138   

<170>  PatentIn version 3.5

<210>  1
<211>  1276
<212>  DNA
<213>  Homo sapiens

<400>  1
cttccctctt cactttgtac ctttctctcc tcgactgtga agcgggccgg gacctgccag       60

gccagaccaa accggacctc gggggcgatg cggctgctgc ccctgctgcg gactgtcctc      120

tgggccgcgt tcctcggctc ccctctgcgc gggggctcca gcctccgcca cgtagtctac      180

tggaactcca gtaaccccag gttgcttcga ggagacgccg tggtggagct gggcctcaac      240

gattacctag acattgtctg cccccactac gaaggcccag ggccccctga gggccccgag      300

acgtttgctt tgtacatggt ggactggcca ggctatgagt cctgccaggc agagggcccc      360

cgggcctaca agcgctgggt gtgctccctg ccctttggcc atgttcaatt ctcagagaag      420

attcagcgct tcacaccctt ctccctcggc tttgagttct tacctggaga gacttactac      480

tacatctcgg tgcccactcc agagagttct ggccagtgct tgaggctcca ggtgtctgtc      540

tgctgcaagg agaggaagtc tgagtcagcc catcctgttg ggagccctgg agagagtggc      600

acatcagggt ggcgaggggg ggacactccc agccccctct gtctcttgct attactgctg      660

cttctgattc ttcgtcttct gcgaattctg tgagccaagc agaccttccc tctcatccca      720

aggagccaga gtcctcccaa gatcccctgg aggaggaggg atccctgctg cctgcactgg      780

gggtgccaat tcagaccgac aagatggagc attgatgggg gagatcagag ggtctgaggt      840

gactcttgca ggagcctgtc ccctcatcac aggctaaaga agagcagtag acagccctgg      900

acactctgaa gcagaggcaa gacaaacaca ggcgctttgc aggctgctct gagggtctca      960

gcccatcccc caggaggact gggatttggt atgatcaaat cctcaagcca gctgggggcc     1020

caggctgaag acctggggac aggtcgattg ctggaccagg gcaaagaaga agccctgcca     1080

tctgtgccct gtgggccttt tccctggggc agcaccttgc cctccccagg ggatcactca     1140

cttgtcttct atgaagacgg actcttcatg aggttgaatt tcatgccagt ttgtattttt     1200

ataagtatct agaccaaacc ttcaataaac cactcatctt tttgttgccc tccccaaaaa     1260

aaaaaaaaaa aaaaaa                                                     1276


<210>  2
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Lys Ser Glu Ser 
145                 150                 155                 160 


Ala His Pro Val Gly Ser Pro Gly Glu Ser Gly Thr Ser Gly Trp Arg 
                165                 170                 175     


Gly Gly Asp Thr Pro Ser Pro Leu Cys Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Ile Leu Arg Leu Leu Arg Ile Leu 
        195                 200     


<210>  3
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Arg Ala Arg Val 
145                 150                 155                 160 


Leu Pro Arg Ser Pro Gly Gly Gly Gly Ile Pro Ala Ala Cys Thr Gly 
                165                 170                 175     


Gly Ala Asn Ser Asp Arg Gln Asp Gly Ala Leu Met Gly Glu Ile Arg 
            180                 185                 190         


Gly Ser Glu Val Thr Leu Ala Gly Ala Cys Pro Leu Ile Thr Gly 
        195                 200                 205         


<210>  4
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Asn Leu Pro Ser 
145                 150                 155                 160 


His Pro Lys Glu Pro Glu Ser Ser Gln Asp Pro Leu Glu Glu Glu Gly 
                165                 170                 175     


Ser Leu Leu Pro Ala Leu Gly Val Pro Ile Gln Thr Asp Lys Met Glu 
            180                 185                 190         


His 
    


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Thr Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Asp Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  6
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  6
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcact acttatggtg tggactgggt ccgccaagct      120

ccagggaagg ggctggagtg gttaggtgta atatggggtg gtggaagcac aaattataat      180

agcgctttga agagccgatt caccatctcc agagacaact ccaagaacac cctgtatctg      240

caaatgaaca gtctgagagc cgaggacacg gccgtgtatt actgtgccag tgattgggct      300

tactggggcc aagggactct ggtcactgtc tcttc                                 335


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  8
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gaatgtgggt acaaatgtag cctggtttca gcagaaacca      120

gggaaagccc ctaagtccct gatccattcg gcatcctacc gttacagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcagcaa tataagaggt atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa ac                                               322


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Lys Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Asp Pro Asn Asp Gly Tyr Tyr Phe Leu Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  10
gaggtgcaac tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaacc attagtagtg gtggtactta cacatactac      180

ccagactcag tgaagggccg attcaaaatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac aagacatgac      300

cccaatgatg gttactactt cctgtttgct tactggggcc aggggactct ggtcactgtc      360

tcttc                                                                  365


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  12
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca aggccagtca gagtgttggc aacaatgtag cttggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctactat gcatccaata ggtatacagg catcccagac      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtgtatta ctgtcaacag cattatagct ctccgctcac gttcggtgct      300

gggaccaagc tggagatcaa ac                                               322


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Phe Asn Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Gly Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  14
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc ggctattaca tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcaattttaa cacaaaatat      180

aacgagcggt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaggat      300

ggtagcccct actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  15

Gly Tyr Tyr Ile His 
1               5   


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  16

Gly Tyr Thr Phe Thr Gly Tyr 
1               5           


<210>  17
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  17
ggctattaca tccac                                                        15


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  18
ggttacacct ttaccggcta t                                                 21


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  19

Trp Ile Tyr Pro Gly Asn Phe Asn Thr Lys Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  20

Tyr Pro Gly Asn Phe Asn 
1               5       


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  21
tggatctacc ctggcaattt taacacaaaa tataacgagc ggttcaaggg c                51


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  22
taccctggca attttaac                                                     18


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  23

Glu Asp Gly Ser Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  24
gaggatggta gcccctacta tgctatggac tac                                    33


<210>  25
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Phe Asn Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Gly Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  26
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  26
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc ggctattaca tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcaattttaa cacaaaatat      180

aacgagcggt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaggat      300

ggtagcccct actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcgccct cgagcaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgagccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggt                                         1347


<210>  27
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  27

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  28
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  28
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgcc ggtctagtca gagcctcgtg catagtaatg gaaacacctt tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctaatct atagagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct ttcaagctac acatgttccg      300

tggacgttcg gtggaggcac caaagtggaa atcaaa                                336


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  29

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu Tyr 
1               5                   10                  15      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  30

Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe 
1               5                   10      


<210>  31
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  31
cggtctagtc agagcctcgt gcatagtaat ggaaacacct ttttgtat                    48


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  32
cagagcctcg tgcatagtaa tggaaacacc ttt                                    33


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  33

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  34
agagtttcca accggttctc t                                                 21


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  35

Phe Gln Ala Thr His Val Pro Trp Thr 
1               5                   


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  36
caagctacac atgttccgtg gacg                                              24


<210>  37
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  37

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  38
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  38
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgcc ggtctagtca gagcctcgtg catagtaatg gaaacacctt tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctaatct atagagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct ttcaagctac acatgttccg      300

tggacgttcg gtggaggcac caaagtggaa atcaaacgga ctgtggctgc accaagtgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Gly Thr His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  40
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  40
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcact tacttctata tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggtgggacaa atcaacccta ataatggtgg cacagcctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatgggtc      300

gggactcact actttgacta ctggggccaa ggcaccactc tcacagtctc ctcc            354


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  41

Tyr Phe Tyr Met Asn 
1               5   


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  42

Gly Tyr Thr Phe Thr Tyr Phe 
1               5           


<210>  43
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  43
tacttctata tgaac                                                        15


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  44
ggatacacct tcacttactt c                                                 21


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  45

Gln Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  46

Asn Pro Asn Asn Gly Gly Thr 
1               5           


<210>  47
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  47
caaatcaacc ctaataatgg tggcacagcc tacgcacaga agttccaggg c                51


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  48
aaccctaata atggtggcac a                                                 21


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  49

Trp Val Gly Thr His Tyr Phe Asp Tyr 
1               5                   


<210>  50
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  50
tgggtcggga ctcactactt tgactac                                           27


<210>  51
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Gly Thr His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  52
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  52
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcact tacttctata tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggtgggacaa atcaacccta ataatggtgg cacagcctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatgggtc      300

gggactcact actttgacta ctggggccaa ggcaccactc tcacagtctc ctccgcctcc      360

accaagggcc catcggtctt ccccctggcg ccctcgagca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgagc cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg t                                               1341


<210>  53
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Tyr Thr Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Asn Phe Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  54
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  54
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctctagct atacttacat tcactggtac      120

caacagaaac ctggccaggc tcccaggctc ctcatcaatt ttgcatccaa cttggaaagt      180

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc      240

agcctagagc ctgaagattt tgcagtttat tactgtcagc acagttggga gattcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  55

Arg Ala Ser Gln Ser Val Ser Ser Ser Ser Tyr Thr Tyr Ile His 
1               5                   10                  15  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  56

Ser Ser Ser Tyr Thr Tyr Ile His 
1               5               


<210>  57
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  57
agggccagtc agagtgttag cagctctagc tatacttaca ttcac                       45


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  58
agctctagct atacttacat tcac                                              24


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  59

Phe Ala Ser Asn Leu Glu Ser 
1               5           


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  60
tttgcatcca acttggaaag t                                                 21


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  61

Gln His Ser Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  62
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  62
cagcacagtt gggagattcc tccgacg                                           27


<210>  63
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Tyr Thr Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Asn Phe Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  64
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  64
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctctagct atacttacat tcactggtac      120

caacagaaac ctggccaggc tcccaggctc ctcatcaatt ttgcatccaa cttggaaagt      180

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc      240

agcctagagc ctgaagattt tgcagtttat tactgtcagc acagttggga gattcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaacggactg tggctgcacc aagtgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  65
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  65

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  66

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  67

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  68

Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  69

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  70

Gly Tyr Thr Phe Thr Arg Asp Trp 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  71

Gly Tyr Thr Phe Thr Tyr Phe Tyr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  72

Gly Tyr Ser Phe Thr Val Tyr Asn 
1               5               


<210>  73
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  73

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  74
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  74

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  75

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  76

Gly Ala Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  77

Phe Asp Pro Glu Thr Gly Asn Thr 
1               5               


<210>  78
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  78

Ile Trp Gly Gly Gly Ser Thr 
1               5           


<210>  79
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  79

Ile Asp Pro Ser Asp Ser Tyr Ile 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  80

Ile Ser Ser Gly Gly Thr Tyr Thr 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  81

Ile Tyr Pro Gly Asn Phe Asn Thr 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  82

Ile His Pro Tyr Asp Ser Glu Thr 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  83

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  84

Ile Asn Pro Tyr Tyr Gly Gly Thr 
1               5               


<210>  85
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  85

Ile Ser Tyr Asp Gly Arg Asn 
1               5           


<210>  86
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  86

Ile Tyr Pro Gly Asn Phe Asn Thr 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  87

Ile His Pro Asn Ser Asp Thr Ile 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  88

Ile Asn Tyr Ser Gly Asn Thr 
1               5           


<210>  89
<211>  10
<212>  PRT
<213>  Mus spretus

<400>  89

Ala Arg Gly Tyr Pro Ala Trp Phe Gly Tyr 
1               5                   10  


<210>  90
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  90

Ala Ser Asp Trp Ala Tyr 
1               5       


<210>  91
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  91

Ala Arg Glu Arg Leu Ser His Ala Met Asp Tyr 
1               5                   10      


<210>  92
<211>  15
<212>  PRT
<213>  Mus spretus

<400>  92

Thr Arg His Asp Pro Asn Asp Gly Tyr Tyr Phe Leu Phe Ala Tyr 
1               5                   10                  15  


<210>  93
<211>  13
<212>  PRT
<213>  Mus spretus

<400>  93

Ala Arg Glu Asp Gly Ser Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  94
<211>  17
<212>  PRT
<213>  Mus spretus

<400>  94

Val Thr Phe Ile Lys Thr Met Val Asp Thr Tyr Tyr Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  95
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  95

Ala Arg Trp Val Gly Thr His Tyr Phe Asp Tyr 
1               5                   10      


<210>  96
<211>  15
<212>  PRT
<213>  Mus spretus

<400>  96

Ala Arg Gly Gly Lys Thr Gly Thr Tyr Tyr Tyr Val Met Asp Tyr 
1               5                   10                  15  


<210>  97
<211>  12
<212>  PRT
<213>  Mus spretus

<400>  97

Ala Arg Glu Gly Tyr Gly Asp Tyr Pro Phe Asp Tyr 
1               5                   10          


<210>  98
<211>  13
<212>  PRT
<213>  Mus spretus

<400>  98

Ala Arg Glu Asp Gly Ser Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  99
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  99

Ala Thr Pro Glu Arg Arg Arg Ala Met Asp Tyr 
1               5                   10      


<210>  100
<211>  14
<212>  PRT
<213>  Mus spretus

<400>  100

Ala Arg Ser Thr Met Ile Thr Thr Gly Ala Trp Phe Ala Tyr 
1               5                   10                  


<210>  101
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  101

Gln Ser Leu Ala His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  102
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  102

Gln Asn Val Gly Thr Asn 
1               5       


<210>  103
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  103

Gln Asp Ile Lys Ser Tyr 
1               5       


<210>  104
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  104

Gln Ser Val Gly Asn Asn 
1               5       


<210>  105
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  105

Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  106

Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  107
<211>  10
<212>  PRT
<213>  Mus spretus

<400>  107

Gln Ser Val Ser Ser Ser Ser Tyr Thr Tyr 
1               5                   10  


<210>  108
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  108

Glu Asn Ile Asp Ser Tyr 
1               5       


<210>  109
<211>  10
<212>  PRT
<213>  Mus spretus

<400>  109

Gln Ser Val Ser Ser Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  110
<211>  11
<212>  PRT
<213>  Mus spretus

<400>  110

Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe 
1               5                   10      


<210>  111
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  111

Ser Ser Leu Ser Ser Ser Tyr 
1               5           


<210>  112
<211>  6
<212>  PRT
<213>  Mus spretus

<400>  112

Gln Ser Val Ser Lys Asp 
1               5       


<210>  113
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  113

Lys Val Ser Asn Met Arg Phe Ser 
1               5               


<210>  114
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  114

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  115

Tyr Ala Thr Ser Leu Ala Asp 
1               5           


<210>  116
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  116

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  117
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  117

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  118
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  118

Leu Val Ser Asn Leu Asp Ser 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  119

Phe Ala Ser Asn Leu Glu Ser 
1               5           


<210>  120
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  120

Ala Ala Thr Leu Leu Ala Asp 
1               5           


<210>  121
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  121

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  122
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  122

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  123
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  123

Ser Thr Ser Phe Leu Ala Ser 
1               5           


<210>  124
<211>  7
<212>  PRT
<213>  Mus spretus

<400>  124

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  125

Ser Gln Asp Thr His Val Pro Pro Thr 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  126

Gln Gln Tyr Lys Arg Tyr Pro Tyr Thr 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  127

Leu Gln His Gly Glu Ser Pro Tyr Thr 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  128

Gln Gln His Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  129

Phe Gln Ala Thr His Val Pro Trp Thr 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  130

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  131

Gln His Ser Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  132
<211>  8
<212>  PRT
<213>  Mus spretus

<400>  132

Gln His Tyr Tyr Ser Thr Leu Thr 
1               5               


<210>  133
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  133

Gln His Ser Trp Glu Ile Pro Arg Thr 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  134

Phe Gln Ala Thr His Val Pro Trp Thr 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  135

Gln Gln Tyr Asp Ser Ser Pro Phe Thr 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Mus spretus

<400>  136

Gln Gln Asp Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  137
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu 
1               5                   10      


<210>  138
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  138

Arg Leu Leu Arg Gly Asp Ala Val Val Glu 
1               5                   10  


