                                SEQUENCE LISTING

<110> The Regents of the University of California

<120> Treatment of Metastatic Prostate Cancer
  

<130> 76916-920845

<140> WO PCT/US14/62455   
<141> 2014-10-27  

<150> US 61/896,250       
<151> 2013-10-28  

<150> US 61/914,389       
<151> 2013-12-11  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> synthetic small interfering RNA (siRNA) targeting
      androgen receptor (AR) Exon7 sequence

<400> 1
ucaaggaacu cgaucguau                                              19

<210> 2
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> synthetic small interfering RNA (siRNA) targeting
      androgen receptor (AR) splice variant 7 (AR-V7) sequence

<400> 2
guaguuguaa guaucauga                                              19

<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic small interfering RNA (siRNA) control
      sequence siControl targeting luciferase (Luc) gene

<400> 3
cttacgctga gtacttcga                                              19

<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) full length
      primer for real-time PCR

<400> 4
aagccagagc tgtgcagatg a                                           21

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) full length
      primer for real-time PCR

<400> 5
cttggtcacc gacgtcctgt                                             20

<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1
      (AR-V1) primer for real-time PCR

<400> 6
aacagaagta cctgtgcgcc                                             20

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1
      (AR-V1) primer for real-time PCR

<400> 7
actcccacaa acctcagagt                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 7
      (AR-V7) primer for real-time PCR

<400> 8
aacagaagta cctgtgcgcc                                             20

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 7
      (AR-V7) primer for real-time PCR

<400> 9
agttttactg gtctgggact                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1/2/2b
      (AR-V1/2/2b) primer for real-time PCR

<400> 10
tggatggata gctactccgg                                             20

<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1/2/2b
      (AR-V1/2/2b) primer for real-time PCR

<400> 11
cgacttccta aaaagtctta cttg                                        24

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1/2/3/2b
      (AR-V1/2/3/2b) primer for real-time PCR

<400> 12
aacagaagta cctgtgcgcc                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic androgen receptor (AR) splice variant 1/2/3/2b
      (AR-V1/2/3/2b) primer for real-time PCR

<400> 13
gtggttaccc tgactgtctt                                             20

<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic actin primer for real-time PCR

<400> 14
agaactggcc cttcttggag g                                           21

<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic actin primer for real-time PCR

<400> 15
gggtatctcc ttgtattttt g                                           21

<210> 16
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic prostate-specific antigen (PSA) promotor
      proximal binding site androgen response element
      (AREI/II) primer for ChIP assay

<400> 16
cctagatgaa gtctccatga gctaca                                      26

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic prostate-specific antigen (PSA) promotor
      proximal binding site androgen response element
      (AREI/II) primer (proximal) for ChIP assay

<400> 17
gttcacgatc gagagggagg g                                           21

<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic aldo-keto reductase family 1 member C3 (AKR1C3,
      17betaHSD5) forward primer for real-time PCR

<400> 18
gagaagtaaa gctttggagg tcaca                                       25

<210> 19
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic aldo-keto reductase family 1 member C3 (AKR1C3,
      17betaHSD5) reverse primer for real-time PCR

<400> 19
caacctgctc ctcattattg tataaatga                                   29

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic aldo-keto reductase family 1 member 1/2 (AKR1C1/2)
      forward primer for real-time PCR

<400> 20
ggtcacttca tgcctgtcct                                             20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic aldo-keto reductase family 1 member 1/2 (AKR1C1/2)
      reverse primer for real-time PCR

<400> 21
actctggtcg atgggaattg                                             20

<210> 22
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD3B1 forward primer for real-time PCR

<400> 22
agaatctaga ccactcttct gtccagcttt                                  30

<210> 23
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD3B1 reverse primer for real-time PCR

<400> 23
ctttgaattc aactatgtga aggaatggaa                                  30

<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD3B2 forward primer for real-time PCR

<400> 24
cgggcccaac tcctacaag                                              19

<210> 25
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD3B2 reverse primer for real-time PCR

<400> 25
ttttccagag gctcttcttc gt                                          22

<210> 26
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic CYP17A1 forward primer for real-time PCR

<400> 26
gggcggcctc aaatgg                                                 16

<210> 27
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic CYP17A1 reverse primer for real-time PCR

<400> 27
cagcgaaggc gaaggcgata ccctta                                      26

<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD17B3 forward primer for real-time PCR

<400> 28
tgggacagtg ggcagtga                                               18

<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic HSD17B3 reverse primer for real-time PCR

<400> 29
cgagtacgct ttcccaattc c                                           21

<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic SRD5A1 forward primer for real-time PCR

<400> 30
acgggcatcg gtgcttaat                                              19

<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic SRD5A1 reverse primer for real-time PCR

<400> 31
ccaacagtgg cataggcttt c                                           21


