                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
 
<120>  DIAGNOSTIC METHODS AND KITS FOR DETERMINING A PERSONALIZED 
       TREATMENT REGIMEN FOR A SUBJECT SUFFERING FROM A PATHOLOGIC 
       DISORDER

<130>  2313186

<150>  US 61/898,847
<151>  2013-11-01

<160>  140   

<170>  PatentIn version 3.5

<210>  1
<211>  3231
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctctcaca cacacccccg cttgggcctc ctctctctct ccggctccat tttctccgcc       60

gccgggggcc ggggtctcct gtggggggcc cagccggtat cccaggtctc ccttcagtgc      120

cggggtgaac ccccggggga gccgggagcc gggggcagac gggcgggggt tggggcggag      180

ggagcagcgg ccccagcgag tttgggggga gaagtaacca ggcgggggga ggggcggagc      240

agggaggggg cctcagggcc cccccccagc tatggacgaa cggctactgg ggccgccccc      300

tccaggcggg ggccgggggg gcctgggatt ggtgagtggg gagcctgggg gccctggcga      360

gcctcccggt ggcggagacc ccggtggggg tagcgggggg gtcccgggag gccgagggaa      420

gcaagacatc ggggacattc tgcagcagat aatgaccatc accgaccaga gcctggacga      480

ggcccaggcc aagaaacacg ccctaaactg ccaccgaatg aagcctgctc tctttagcgt      540

cctgtgtgaa atcaaggaga aaactggcct cagcattcgg agctcccagg aggaggagcc      600

ggtggaccca cagctgatgc gcttggacaa catgcttctg gcagagggtg tggctgggcc      660

cgagaaaggg ggcggctcag cagcagcagc tgcagccgct gcagcctctg gtggtggtgt      720

gtcccctgac aactccatcg aacactcgga ctatcgcagc aaacttgccc agatccgtca      780

catataccac tcggagctgg agaagtatga gcaggcatgt aatgagttca cgacccatgt      840

catgaacctg ctgagggagc agagccgcac caggcccgtg gcccccaaag agatggaacg      900

catggtgagc atcatccatc gaaagttcag cgccatccag atgcagctga agcagagcac      960

ctgcgaggct gtgatgatcc tgcgctcccg tttcctggat gccagacgaa agcgccgtaa     1020

cttcagcaaa caggccactg aggtcctaaa tgagtatttc tactcccacc tgagtaaccc     1080

atatcctagt gaggaggcca aggaggagct tgccaagaag tgtggcatca ccgtgtctca     1140

ggtctccaac tggtttggca acaagaggat tcgctataag aaaaacatcg gaaagttcca     1200

agaggaggca aacatctatg ctgtcaagac cgccgtgtca gtcacccagg ggggccacag     1260

ccgcaccagc tccccgacac ccccttcctc tgcaggctct ggcggctctt tcaatctctc     1320

aggatctgga gacatgtttc tggggatgcc tgggctcaac ggagattcct attctgcttc     1380

ccaggtggaa tcactccgac actcgatggg gccagggggc tatggggata acctcggggg     1440

aggccagatg tacagcccac gggaaatgag ggcaaatggc agctggcaag aggctgtgac     1500

cccctcttca gtgacatccc caacggaggg accagggagt gttcactctg atacctccaa     1560

ctgatcttgc ccctcagggt cacaggggtg ggggctctca caaggcgact tgaagaggac     1620

gcaggcttcc agaggacaaa ccccaataca ggagaagcac aagacagaga agggccaatg     1680

gggtcatccc ctccctaacg agactctctg tgctgggggt gctaattaca tggcaggaag     1740

aatggggcct ctaaggggag tgtggggtct gtctctccct tttttccatc tttttcctct     1800

ctcgctttct ttcttacaca gaaacataca cataccgaga aacctatttc tcagacccct     1860

ttttctcctc tgtctttctc tctccctctc ccacacctca cacacacata ctcccacttg     1920

caactattct gtttctctcc tgggctcccc cactttccct tccccacccc acttgtatgc     1980

tctggaatct gtggagacgc cagccctgcc caatcagaga tgccaaaaat ggggacatga     2040

cttctggaca gaggacatgg gccacgcccc catgcatccc cacccccgcc cctccggacg     2100

gcttacttac ctcatacgca gctcatctta aaccaataga atcgctcggt ggacgagagt     2160

gtctgactca gatatctacc tcggagggag tttctgctac tttagggaat tattgactgg     2220

gctttggggt tgaacttttt tttttttaaa gaaagaaaaa gaaaccctgg gatccatctg     2280

ttttttttgt tgttgttgtt gtttttgttg ttgttggtgg tggtggtggt ggtggttctt     2340

aatttttaat ttagtttggg gaagtagctt gttttttttt ttataaatat gttgatttct     2400

tgtctttttt tttttttatt tcttactttc ccatattagg ggtgatagcc aaaggggttc     2460

tggtaagaga aagggggaca aacagaactg gtaaagaggc ccccctggct ccaggcctgt     2520

ccatcaggaa gtaaatttta cagggcacca agctttgccc cctaaaatcc cttaggtgtt     2580

ctttgttcat gcaggcaggt ttctgccgca tttgatgtgg aggcagtgaa gggcttgccc     2640

tgctggcctc tcatccccct tcttcccaca acccttgggc agggctggac tcagtaattt     2700

tgaggaaatt gaagatgcca tcttcccctg tgagtgacat gtctttaatt ttttaaaaaa     2760

ctactatttg aaaattggag ggggaagaat gggaagggag ttattgccaa atatgttaaa     2820

tatgggttgg ggtgcttgta tatgtatctt cctcaatttc cccataaatg aggtatcttt     2880

ttgtcacacc aaaatcaagg ggtagggaga gggaggaggt tgcaaaaagc cagatgtggg     2940

ggaaaagtaa catcaacact gtcccatcct cagccctgaa ctagctacca tctgatcccc     3000

tcagacattc tcaggatttt acaagactgt cagagtgggg aacccctccc attaaagatc     3060

cgggcaggac tggggacagg ttggaagtgt gatgggtggg ggggtgggag gcatgggccg     3120

ggggcagttc tctcctcact tgtaaacttg tgtagtttca cagaaaaaaa acaaaatgca     3180

gttttaaata aagaaatttc ttttttccct gggaaaaaaa aaaaaaaaaa a              3231


<210>  2
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Glu Arg Leu Leu Gly Pro Pro Pro Pro Gly Gly Gly Arg Gly 
1               5                   10                  15      


Gly Leu Gly Leu Val Ser Gly Glu Pro Gly Gly Pro Gly Glu Pro Pro 
            20                  25                  30          


Gly Gly Gly Asp Pro Gly Gly Gly Ser Gly Gly Val Pro Gly Gly Arg 
        35                  40                  45              


Gly Lys Gln Asp Ile Gly Asp Ile Leu Gln Gln Ile Met Thr Ile Thr 
    50                  55                  60                  


Asp Gln Ser Leu Asp Glu Ala Gln Ala Lys Lys His Ala Leu Asn Cys 
65                  70                  75                  80  


His Arg Met Lys Pro Ala Leu Phe Ser Val Leu Cys Glu Ile Lys Glu 
                85                  90                  95      


Lys Thr Gly Leu Ser Ile Arg Ser Ser Gln Glu Glu Glu Pro Val Asp 
            100                 105                 110         


Pro Gln Leu Met Arg Leu Asp Asn Met Leu Leu Ala Glu Gly Val Ala 
        115                 120                 125             


Gly Pro Glu Lys Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ser Gly Gly Gly Val Ser Pro Asp Asn Ser Ile Glu His Ser Asp 
145                 150                 155                 160 


Tyr Arg Ser Lys Leu Ala Gln Ile Arg His Ile Tyr His Ser Glu Leu 
                165                 170                 175     


Glu Lys Tyr Glu Gln Ala Cys Asn Glu Phe Thr Thr His Val Met Asn 
            180                 185                 190         


Leu Leu Arg Glu Gln Ser Arg Thr Arg Pro Val Ala Pro Lys Glu Met 
        195                 200                 205             


Glu Arg Met Val Ser Ile Ile His Arg Lys Phe Ser Ala Ile Gln Met 
    210                 215                 220                 


Gln Leu Lys Gln Ser Thr Cys Glu Ala Val Met Ile Leu Arg Ser Arg 
225                 230                 235                 240 


Phe Leu Asp Ala Arg Arg Lys Arg Arg Asn Phe Ser Lys Gln Ala Thr 
                245                 250                 255     


Glu Val Leu Asn Glu Tyr Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro 
            260                 265                 270         


Ser Glu Glu Ala Lys Glu Glu Leu Ala Lys Lys Cys Gly Ile Thr Val 
        275                 280                 285             


Ser Gln Val Ser Asn Trp Phe Gly Asn Lys Arg Ile Arg Tyr Lys Lys 
    290                 295                 300                 


Asn Ile Gly Lys Phe Gln Glu Glu Ala Asn Ile Tyr Ala Val Lys Thr 
305                 310                 315                 320 


Ala Val Ser Val Thr Gln Gly Gly His Ser Arg Thr Ser Ser Pro Thr 
                325                 330                 335     


Pro Pro Ser Ser Ala Gly Ser Gly Gly Ser Phe Asn Leu Ser Gly Ser 
            340                 345                 350         


Gly Asp Met Phe Leu Gly Met Pro Gly Leu Asn Gly Asp Ser Tyr Ser 
        355                 360                 365             


Ala Ser Gln Val Glu Ser Leu Arg His Ser Met Gly Pro Gly Gly Tyr 
    370                 375                 380                 


Gly Asp Asn Leu Gly Gly Gly Gln Met Tyr Ser Pro Arg Glu Met Arg 
385                 390                 395                 400 


Ala Asn Gly Ser Trp Gln Glu Ala Val Thr Pro Ser Ser Val Thr Ser 
                405                 410                 415     


Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr Ser Asn 
            420                 425                 430 


<210>  3
<211>  5515
<212>  DNA
<213>  Homo sapiens

<400>  3
cagcccggga atcaaccacc ggaagtgccg gccctgagag gtggagtcgg ggtggcagcg       60

gcggcggttg ccaggagccc gcgttgcagc ctgagatccg taatatggcg gggaggagga      120

ggagaaggcg gcggcggacc gagctgcgct ctgtcagtac catttgagcc attcgcttcc      180

tgacaaggcc cgtggcgagg ggagaggagc tgaaggggcc gtgggggatc agtgcctgct      240

gtgtgctgat actgttctgt gtaatgggga ttcagtgaac aagactgaaa aggtacctgt      300

acttatggcg cttacatttt ggtggaggaa gacagacaaa aatcaaggaa ataaacacga      360

taatttcaga tagtgtgtga ctgtgggaag atggaggagt atgagaagtt ctgtgaaaaa      420

agtcttgcca gaatacaaga agcatcacta tccacagaga gctttctccc tgctcagtct      480

gaaagtatct cacttattcg ctttcatgga gtggctatcc tttctccact gcttaacatt      540

gagaaaagaa aggaaatgca acaagaaaag cagaaagcac ttgatgtaga agcaagaaag      600

caggttaaca ggaagaaagc tttactgact cgtgtccagg agattcttga caatgttcag      660

gttagaaaag cacctaatgc cagtgatttt gatcagtggg agatggaaac agtttactct      720

aattcagaag tcagaaactt gaatgttcct gctacatttc caaatagctt tccaagccat      780

acggaacact ctactgcagc aaagcttgat aagatagctg ggattttgcc attggataat      840

gaggaccaat gtaaaactga tggaatagac ttagctagag attcagaagg atttaattct      900

ccgaagcaat gtgatagttc caatattagt catgtagaaa atgaagcttt tccaaagacc      960

tcttcagcaa ccccacaaga aactcttatt tctgatggtc ccttctcagt aaatgaacaa     1020

caggatctac cacttttggc agaagtcatc ccagatccct atgtaatgag tcttcagaat     1080

ctgatgaaaa agtcaaagga atatatagaa agagaacaat ctagacgcag tctgagaggt     1140

agtatgaaca gaattgttaa tgagagtcat ttagacaaag aacatgatgc tgttgaagtg     1200

gctgactgtg taaaagagaa aggccagttg acaggcaaac actgtgtctc agttattcct     1260

gacaaaccaa gccttaataa atcaaatgtt cttctccaag gtgcttccac tcaagcaagc     1320

agcatgagta tgccagtttt agctagcttt tcgaaagtgg acatacctat acgaactggc     1380

catcccactg ttctagagtc taattctgat tttaaagtta ttcccacttt tgttaccgaa     1440

aataatgtta tcaaaagtct tacaggttca tatgccaaat tacctagtcc agagccaagt     1500

atgagtccta aaatgcaccg aagacgttcc aggacatcat cagcgtgtca tatacttata     1560

aataacccaa taaatgcctg tgaattaagc cctaaaggaa aagaacaggc aatggactta     1620

attattcaag atactgatga aaacacaaat gtgcccgaaa ttatgccaaa gttaccaact     1680

gatttagcgg gagtttgttc aagcaaggtt tatgtgggca aaaatacatc tgaagtcaaa     1740

gaagatgtgg ttttaggtaa atcaaatcag gtatgtcaat cttcaggaaa tcatttagaa     1800

aataaagtta ctcatggact tgttactgtg gaaggtcagt taacatccga tgagagaggc     1860

gcacacataa tgaacagtac ctgtgctgcg atgccaaagc tgcatgaacc atatgccagc     1920

agtcagtgta tagcaagtcc aaactttgga actgtgagtg gactcaagcc agccagtatg     1980

ttagagaaaa actgcagttt gcaaacagaa ctgaataagt cttatgatgt aaaaaaccct     2040

tctcctttat tgatgcaaaa ccagaatacg agacagcaga tggacacacc tatggtgtcc     2100

tgtggaaatg aacaattttt ggataacagt tttgagaaag ttaaacggag acttgattta     2160

gatattgatg gtttgcaaaa agaaaactgc ccttatgtca taacaagtgg aataactgaa     2220

caagaaaggc aacatttgcc agaaaaaaga taccctaagg gatctggctt cgttaacaag     2280

aataaaatgt taggaactag ttccaaagaa agcgaggagt tactaaaaag caagatgtta     2340

gcttttgaag aaatgcggaa gagactagaa gaacagcacg cccagcaatt atcactactc     2400

atagctgagc aggaaaggga acaagaaaga ctgcaaaagg aaatagaaga gcaggagaaa     2460

atgttaaaag agaagaaggc aatgacagcg gaagcctctg agttggacat taacaatgca     2520

gtggaattag aatggagaaa aataagtgac tctagtttgc tggaaacaat gctgtctcaa     2580

gcggactcac tccatacttc aaattcaaat agttctggtt tcacaaattc tgccatgcaa     2640

tatagctttg tttctgcaaa cgaagcacca ttctacctct ggggatcatc aactagtggc     2700

ttgaccaaac tctcagtaac aaggcctttt ggaagagcca aaactagatg gtctcaagtt     2760

tttagtctgg aaatacaagc aaaatttaac aaaataactg cagtggcaaa aggatttctt     2820

actcgtagac ttatgcagac agataagctg aagcaacttc gacaaactgt aaaagatact     2880

atggaattca taagaagttt tcagtcagaa gcaccattaa agagaggcat tgtttcagct     2940

caagatgctt cacttcagga aagagtgtta gctcagttgc gagctgcctt gtacggtatt     3000

catgacatat tctttgtaat ggatgcagct gaaagaatgt ctattctaca tcatgatcga     3060

gaagttcgca aagagaaaat gctcaggcaa atggataaaa tgaaaagtcc acgagtggct     3120

ctttcagctg caacacagaa gtctcttgat aggaagaaat acatgaaagc tgctgaaatg     3180

ggaatgccaa ataagaaatt tctggttaaa caaaatcctt ctgaaacaag agtccttcag     3240

ccaaaccaag gacagaatgc acctgttcat aggctactta gtagacaagg gagtatatgc     3300

aggaaaaatc caaagaaagc ggccaaatgt tgcgacaatt taagaagaca acattcatta     3360

ggataaaatg gggggaagga ttattattca tgttattttc cctgcccaag actttattta     3420

accctggact ccgtttacac agacaaagtg acatcagaag gctgagcact tatctggatc     3480

atttggtcag tttggtaatt cctgctccac acccctattt tcctcttaat aatacgtttg     3540

ggtgaagaca aattagtgtt tagtaattgc atcatctctg tgcttaccta tacaaacata     3600

agtttatttt atatgcccag atgtctacag agaccctttt tgtaaatgtc aaggacattt     3660

ggatttactt ttacagaata ttgaaaagat aagacaaatt ataaataagt tctaaaacat     3720

aaatttaatt catctctgca tagtgatttt tgaatttgat tcaaagggaa attattgcag     3780

aagaatgcct ttccctcatt ttataacttt aaaaacttgg attaaccact caatgtccac     3840

tttctttgac ttacagtata accatgtagc caattgtggc ccactaaaat ctacagaagt     3900

taatgtgggt caccattttg gtcagaagca tacattcctg tcagacaact agttgtctga     3960

cagaaatgtt aggcttcatg tatgttaccc cagtactgtt agaaacattt gtactaggtt     4020

ataagatctt tctgtgacag gtaacaaatt tggggaagac agcacaatct tcttgaatgt     4080

agctcttggg aatgcattat tacatccatt tctgtaacat aataatatgt tgcatgcagt     4140

tatattttct atttagtctg tatattttgt tcttcatagt ctgttttttc tagcatgctt     4200

gatttaggag agaataaagg gctatataat aataaatcca gatttccgga taagaatatt     4260

gcctggttaa aattctgcat tgcttaaaga cacccatgtt taagattttt catcactaac     4320

atatccatta aaagtatcaa ctggccaggc agggtggctc acgcctgtac tcccagcatt     4380

ttgtgaggcc aaggtgggtg gatcacctga ggtcaggagt ttgagaccag cctgaccaaa     4440

catggcgaaa ccccatctgt actgaaaata caaaaattag gcatggtggt gcatgcctgt     4500

agttccagct acttgggagg ctgagacagg cgaattgctt gaacctggga ggcagaggtt     4560

gcagtgagct gagactgtgc cattgcactc cagtcgggtt aacagagcaa gacactgtct     4620

caaaaaaaaa aaaaaaaaaa agtatcaacc aacaaatgtt accaagataa cgtgacttca     4680

tgagggagaa tgtcactatt aatttatcat accatttcca aaaagggctt tgtgcttttc     4740

acataaaatt gagacagtgt atatttaatc taatttaaat tttaaagaga tactggtatt     4800

ttgaaaatgc aacctatata tattcttaat atccttttaa gaatatggag atgaagattg     4860

ttttctccaa ttttctgtgc cattttaaat ttaactttga catccagcta tagacagaaa     4920

taataagcca ccctgggtgt aaacttgatt ttctttattg agatgtatca tgtattgaat     4980

gagtgaacca gaaaattaga agatggtcaa aaaaagtcca agttaccaat tttttaaaat     5040

ttataggcaa agtatcaaat tgtcttctta atatgataaa ctgtgcttta tcattctgaa     5100

aactcaggat acagcttatt catagcattg tgggtctctc cagtaagaaa gatgctaaaa     5160

gttttgtgca ctttttgtgt gtgtaatgca aattagttaa aacaaatagt tttggagaaa     5220

gttaaaacta gctttagagt aaggatgaga aacttgagtg tttttaattt aaagataaaa     5280

gcctgtgttt tacacattct tttttggtgt tcatagcttc ttctcataca ggtgccagac     5340

actgtttgtg cttttgatgg atttttattt atatactttt tttgcttatt tttactttga     5400

gtggaatgtt cattaatgta aattgtattt atttttatac ttttattttc actagttttg     5460

cttctaggca aaaagcaaaa taaacttttc atcttaaaga aaaaaaaaaa aaaaa          5515


<210>  4
<211>  991
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Met Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Ser Ile Cys Arg Lys Asn Pro Lys Lys 
                965                 970                 975     


Ala Ala Lys Cys Cys Asp Asn Leu Arg Arg Gln His Ser Leu Gly 
            980                 985                 990     


<210>  5
<211>  5458
<212>  DNA
<213>  Homo sapiens

<400>  5
cagcccggga atcaaccacc ggaagtgccg gccctgagag gtggagtcgg ggtggcagcg       60

gcggcggttg ccaggagccc gcgttgcagc ctgagatccg taatatggcg gggaggagga      120

ggagaaggcg gcggcggacc gagctgcgct ctgtcagtac catttgagcc attcgcttcc      180

tgacaaggcc cgtggcgagg ggagaggagc tgaaggggcc gtgggggatc agtgtgactg      240

tgggaagatg gaggagtatg agaagttctg tgaaaaaagt cttgccagaa tacaagaagc      300

atcactatcc acagagagct ttctccctgc tcagtctgaa agtatctcac ttattcgctt      360

tcatggagtg gctatccttt ctccactgct taacattgag aaaagaaagg aaatgcaaca      420

agaaaagcag aaagcacttg atgtagaagc aagaaagcag gttaacagga agaaagcttt      480

actgactcgt gtccaggaga ttcttgacaa tgttcaggtt agaaaagcac ctaatgccag      540

tgattttgat cagtgggaga tggaaacagt ttactctaat tcagaagtca gaaacttgaa      600

tgttcctgct acatttccaa atagctttcc aagccatacg gaacactcta ctgcagcaaa      660

gcttgataag atagctggga ttttgccatt ggataatgag gaccaatgta aaactgatgg      720

aatagactta gctagagatt cagaaggatt taattctccg aagcaatgtg atagttccaa      780

tattagtcat gtagaaaatg aagcttttcc aaagacctct tcagcaaccc cacaagaaac      840

tcttatttct gatggtccct tctcagtaaa tgaacaacag gatctaccac ttttggcaga      900

agtcatccca gatccctatg taatgagtct tcagaatctg atgaaaaagt caaaggaata      960

tatagaaaga gaacaatcta gacgcagtct gagaggtagt atgaacagaa ttgttaatga     1020

gagtcattta gacaaagaac atgatgctgt tgaagtggct gactgtgtaa aagagaaagg     1080

ccagttgaca ggcaaacact gtgtctcagt tattcctgac aaaccaagcc ttaataaatc     1140

aaatgttctt ctccaaggtg cttccactca agcaagcagc atgagtatgc cagttttagc     1200

tagcttttcg aaagtggaca tacctatacg aactggccat cccactgttc tagagtctaa     1260

ttctgatttt aaagttattc ccacttttgt taccgaaaat aatgttatca aaagtcttac     1320

aggttcatat gccaaattac ctagtccaga gccaagtatg agtcctaaaa tgcaccgaag     1380

acgttccagg acatcatcag cgtgtcatat acttataaat aacccaataa atgcctgtga     1440

attaagccct aaaggaaaag aacaggcaat ggacttaatt attcaagata ctgatgaaaa     1500

cacaaatgtg cccgaaatta tgccaaagtt accaactgat ttagcgggag tttgttcaag     1560

caaggtttat gtgggcaaaa atacatctga agtcaaagaa gatgtggttt taggtaaatc     1620

aaatcaggta tgtcaatctt caggaaatca tttagaaaat aaagttactc atggacttgt     1680

tactgtggaa ggtcagttaa catccgatga gagaggcgca cacataatga acagtacctg     1740

tgctgcgatg ccaaagctgc atgaaccata tgccagcagt cagtgtatag caagtccaaa     1800

ctttggaact gtgagtggac tcaagccagc cagtatgtta gagaaaaact gcagtttgca     1860

aacagaactg aataagtctt atgatgtaaa aaacccttct cctttattga tgcaaaacca     1920

gaatacgaga cagcagatgg acacacctat ggtgtcctgt ggaaatgaac aatttttgga     1980

taacagtttt gagaaagtta aacggagact tgatttagat attgatggtt tgcaaaaaga     2040

aaactgccct tatgtcataa caagtggaat aactgaacaa gaaaggcaac atttgccaga     2100

aaaaagatac cctaagggat ctggcttcgt taacaagaat aaaatgttag gaactagttc     2160

caaagaaagc gaggagttac taaaaagcaa gatgttagct tttgaagaaa tgcggaagag     2220

actagaagaa cagcacgccc agcaattatc actactcata gctgagcagg aaagggaaca     2280

agaaagactg caaaaggaaa tagaagagca ggagaaaatg ttaaaagaga agaaggcaat     2340

gacagcggaa gcctctgagt tggacattaa caatgcagtg gaattagaat ggagaaaaat     2400

aagtgactct agtttgctgg aaacaatgct gtctcaagcg gactcactcc atacttcaaa     2460

ttcaaatagt tctggtttca caaattctgc catgcaatat agctttgttt ctgcaaacga     2520

agcaccattc tacctctggg gatcatcaac tagtggcttg accaaactct cagtaacaag     2580

gccttttgga agagccaaaa ctagatggtc tcaagttttt agtctggaaa tacaagcaaa     2640

atttaacaaa ataactgcag tggcaaaagg atttcttact cgtagactta tgcagacaga     2700

taagctgaag caacttcgac aaactgtaaa agatactatg gaattcataa gaagttttca     2760

gtcagaagca ccattaaaga gaggcattgt ttcagctcaa gatgcttcac ttcaggaaag     2820

agtgttagct cagttgcgag ctgccttgta cggtattcat gacatattct ttgtaatgga     2880

tgcagctgaa agaatgtcta ttctacatca tgatcgagaa gttcgcaaag agaaaatgct     2940

caggcaaatg gataaaatga aaagtccacg agtggctctt tcagctgcaa cacagaagtc     3000

tcttgatagg aagaaataca tgaaagctgc tgaaatggga atgccaaata agaaatttct     3060

ggttaaacaa aatccttctg aaacaagagt ccttcagcca aaccaaggac agaatgcacc     3120

tgttcatagg ctacttagta gacaaggaac ccctaagaca tcagtgaagg gggttgtgca     3180

aaatagacag aagccttcac agagcagagt gcctaacaga gtgcctgttt caggagtata     3240

tgcaggaaaa atccaaagaa agcggccaaa tgttgcgaca atttaagaag acaacattca     3300

ttaggataaa atggggggaa ggattattat tcatgttatt ttccctgccc aagactttat     3360

ttaaccctgg actccgttta cacagacaaa gtgacatcag aaggctgagc acttatctgg     3420

atcatttggt cagtttggta attcctgctc cacaccccta ttttcctctt aataatacgt     3480

ttgggtgaag acaaattagt gtttagtaat tgcatcatct ctgtgcttac ctatacaaac     3540

ataagtttat tttatatgcc cagatgtcta cagagaccct ttttgtaaat gtcaaggaca     3600

tttggattta cttttacaga atattgaaaa gataagacaa attataaata agttctaaaa     3660

cataaattta attcatctct gcatagtgat ttttgaattt gattcaaagg gaaattattg     3720

cagaagaatg cctttccctc attttataac tttaaaaact tggattaacc actcaatgtc     3780

cactttcttt gacttacagt ataaccatgt agccaattgt ggcccactaa aatctacaga     3840

agttaatgtg ggtcaccatt ttggtcagaa gcatacattc ctgtcagaca actagttgtc     3900

tgacagaaat gttaggcttc atgtatgtta ccccagtact gttagaaaca tttgtactag     3960

gttataagat ctttctgtga caggtaacaa atttggggaa gacagcacaa tcttcttgaa     4020

tgtagctctt gggaatgcat tattacatcc atttctgtaa cataataata tgttgcatgc     4080

agttatattt tctatttagt ctgtatattt tgttcttcat agtctgtttt ttctagcatg     4140

cttgatttag gagagaataa agggctatat aataataaat ccagatttcc ggataagaat     4200

attgcctggt taaaattctg cattgcttaa agacacccat gtttaagatt tttcatcact     4260

aacatatcca ttaaaagtat caactggcca ggcagggtgg ctcacgcctg tactcccagc     4320

attttgtgag gccaaggtgg gtggatcacc tgaggtcagg agtttgagac cagcctgacc     4380

aaacatggcg aaaccccatc tgtactgaaa atacaaaaat taggcatggt ggtgcatgcc     4440

tgtagttcca gctacttggg aggctgagac aggcgaattg cttgaacctg ggaggcagag     4500

gttgcagtga gctgagactg tgccattgca ctccagtcgg gttaacagag caagacactg     4560

tctcaaaaaa aaaaaaaaaa aaaagtatca accaacaaat gttaccaaga taacgtgact     4620

tcatgaggga gaatgtcact attaatttat cataccattt ccaaaaaggg ctttgtgctt     4680

ttcacataaa attgagacag tgtatattta atctaattta aattttaaag agatactggt     4740

attttgaaaa tgcaacctat atatattctt aatatccttt taagaatatg gagatgaaga     4800

ttgttttctc caattttctg tgccatttta aatttaactt tgacatccag ctatagacag     4860

aaataataag ccaccctggg tgtaaacttg attttcttta ttgagatgta tcatgtattg     4920

aatgagtgaa ccagaaaatt agaagatggt caaaaaaagt ccaagttacc aattttttaa     4980

aatttatagg caaagtatca aattgtcttc ttaatatgat aaactgtgct ttatcattct     5040

gaaaactcag gatacagctt attcatagca ttgtgggtct ctccagtaag aaagatgcta     5100

aaagttttgt gcactttttg tgtgtgtaat gcaaattagt taaaacaaat agttttggag     5160

aaagttaaaa ctagctttag agtaaggatg agaaacttga gtgtttttaa tttaaagata     5220

aaagcctgtg ttttacacat tcttttttgg tgttcatagc ttcttctcat acaggtgcca     5280

gacactgttt gtgcttttga tggattttta tttatatact ttttttgctt atttttactt     5340

tgagtggaat gttcattaat gtaaattgta tttattttta tacttttatt ttcactagtt     5400

ttgcttctag gcaaaaagca aaataaactt ttcatcttaa agaaaaaaaa aaaaaaaa       5458


<210>  6
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Met Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Thr Pro Lys Thr Ser Val Lys Gly Val 
                965                 970                 975     


Val Gln Asn Arg Gln Lys Pro Ser Gln Ser Arg Val Pro Asn Arg Val 
            980                 985                 990         


Pro Val Ser Gly Val Tyr Ala Gly  Lys Ile Gln Arg Lys  Arg Pro Asn 
        995                 1000                 1005             


Val Ala  Thr Ile 
    1010         


<210>  7
<211>  2176
<212>  DNA
<213>  Homo sapiens

<400>  7
aacgcttcgc tttcgtttcc cgctggcgcc tggctccctc cgggtttcgt ttcccgccgg       60

cgcctggctc ccgccaggtt tcgtttccga ggcggggccg agggcggcgt cgctgaggcg      120

cccatggcct tcgcccgccg gctcctgcgc gggccactgt cggggccgct gctcgggcgg      180

cgcggggtct gcgctggggc catggctccg ccgcgccgct tcgtcctgga gcttcccgac      240

tgcaccctgg ctcacttcgc cctaggcgcc gacgcccccg gcgacgcaga cgcccccgac      300

ccccgcctgg cggcgctgct ggggcccccg gagcgcagct actcgctgtg cgtgcccgtg      360

accccggacg ccggctgcgg ggcccgggtc cgggcggcgc ggctgcacca gcgcctgctg      420

caccagctgc gccgcggccc cttccagcgg tgccagctgc tcaggctgct ctgctactgc      480

ccgggcggcc aggccggcgg cgcacagcaa ggcttcctgc tgcgcgaccc cctggatgac      540

cctgacaccc ggcaagcgct gctcgagctg ctgggcgcct gtcaggaggc accacgcccg      600

cacttgggcg agttcgaggc cgacccgcgc ggccagctgt ggcagcgcct ctgggaggtg      660

caagacggca ggcggctgca ggtgggctgc gcacaggtcg tgcccgtccc ggagcccccg      720

ctgcacccgg tggtgccaga cttgcccagt tccgtggtct tcccggaccg ggaagccgcc      780

cgggccgttt tggaggagtg tacctccttt attcctgaag cccgggcagt gcttgacctg      840

gtcgaccagt gcccaaaaca gatccagaaa ggaaagttcc aggttgttgc catcgaagga      900

ctggatgcca cgggtaaaac cacggtgacc cagtcagtgg cagattcact taaggctgtc      960

ctcttaaagt caccaccctc ttgcattggc cagtggagga agatctttga tgatgaacca     1020

actatcatta gaagagcttt ttactctttg ggcaattata ttgtggcctc cgaaatagct     1080

aaagaatctg ccaaatctcc tgtgattgta gacaggtact ggcacagcac ggccacctat     1140

gccatagcca ctgaggtgag tgggggtctc cagcacctgc ccccagccca tcaccctgtg     1200

taccagtggc cagaggacct gctcaaacct gaccttatcc tgctgctcac tgtgagtcct     1260

gaggagaggt tgcagaggct gcagggccgg ggcatggaga agaccaggga agaagcagaa     1320

cttgaggcca acagtgtgtt tcgtcaaaag taggtgtccc agtgcaatgc aatgtgagcg     1380

gcaggcattc ctgaagggag atgaaccact ggcactggct ttaggattgt gaggaagtga     1440

tattgtttcc agttttcaaa cacaagagac aacatcctct aagttacttc agccccttcc     1500

aatgggcttg tcaccacagg gctgcagcat tgttatctta aagcaaaggt catcggacta     1560

gggatcagac cctgccactg atcctggctg tgctaggagc agctgcacct gggtaagaca     1620

gtaagtgtct ctgtgcctca gtttccccag tcatagtata atcacacaga gcactagata     1680

acgagctcat agtaacatct acctattaga tgcttcccgt gtgtcaggca ttttactgat     1740

gttatgtcat ccttgtgagg aaaacattag ccgtatttta cagtttacaa ctttaaggct     1800

caaaggatta agtgatttgt ctaaatgtac ataactattc actagtaaaa ccgggattaa     1860

aatctttctg attttgcagc cagtgttttt gttttaatta gaaagttata aacacgactg     1920

cagaagagag tctggccagg cctcctgcct catgactgag tatgaatcag ttctacacca     1980

ctgcctttaa aaactgaagc agaaatattt tctctaactg aacaatgata gccctgttat     2040

cataacatag taatgttata aataatggta gctgctgtgg gtaaagatat tatgttaagc     2100

aatttacttg tattaattcc attaaacttc agtgaacatt tgcaaggaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaa                                                     2176


<210>  8
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Leu Leu Lys Ser Pro Pro Ser Cys Ile 
        275                 280                 285             


Gly Gln Trp Arg Lys Ile Phe Asp Asp Glu Pro Thr Ile Ile Arg Arg 
    290                 295                 300                 


Ala Phe Tyr Ser Leu Gly Asn Tyr Ile Val Ala Ser Glu Ile Ala Lys 
305                 310                 315                 320 


Glu Ser Ala Lys Ser Pro Val Ile Val Asp Arg Tyr Trp His Ser Thr 
                325                 330                 335     


Ala Thr Tyr Ala Ile Ala Thr Glu Val Ser Gly Gly Leu Gln His Leu 
            340                 345                 350         


Pro Pro Ala His His Pro Val Tyr Gln Trp Pro Glu Asp Leu Leu Lys 
        355                 360                 365             


Pro Asp Leu Ile Leu Leu Leu Thr Val Ser Pro Glu Glu Arg Leu Gln 
    370                 375                 380                 


Arg Leu Gln Gly Arg Gly Met Glu Lys Thr Arg Glu Glu Ala Glu Leu 
385                 390                 395                 400 


Glu Ala Asn Ser Val Phe Arg Gln Lys 
                405                 


<210>  9
<211>  1241
<212>  DNA
<213>  Homo sapiens

<400>  9
aacgcttcgc tttcgtttcc cgctggcgcc tggctccctc cgggtttcgt ttcccgccgg       60

cgcctggctc ccgccaggtt tcgtttccga ggcggggccg agggcggcgt cgctgaggcg      120

cccatggcct tcgcccgccg gctcctgcgc gggccactgt cggggccgct gctcgggcgg      180

cgcggggtct gcgctggggc catggctccg ccgcgccgct tcgtcctgga gcttcccgac      240

tgcaccctgg ctcacttcgc cctaggcgcc gacgcccccg gcgacgcaga cgcccccgac      300

ccccgcctgg cggcgctgct ggggcccccg gagcgcagct actcgctgtg cgtgcccgtg      360

accccggacg ccggctgcgg ggcccgggtc cgggcggcgc ggctgcacca gcgcctgctg      420

caccagctgc gccgcggccc cttccagcgg tgccagctgc tcaggctgct ctgctactgc      480

ccgggcggcc aggccggcgg cgcacagcaa ggcttcctgc tgcgcgaccc cctggatgac      540

cctgacaccc ggcaagcgct gctcgagctg ctgggcgcct gtcaggaggc accacgcccg      600

cacttgggcg agttcgaggc cgacccgcgc ggccagctgt ggcagcgcct ctgggaggtg      660

caagacggca ggcggctgca ggtgggctgc gcacaggtcg tgcccgtccc ggagcccccg      720

ctgcacccgg tggtgccaga cttgcccagt tccgtggtct tcccggaccg ggaagccgcc      780

cgggccgttt tggaggagtg tacctccttt attcctgaag cccgggcagt gcttgacctg      840

gtcgaccagt gcccaaaaca gatccagaaa ggaaagttcc aggttgttgc catcgaagga      900

ctggatgcca cgggtaaaac cacggtgacc cagtcagtgg cagattcact taaggctgtc      960

ctcttaaagt caccaccctc ttgcattggc cagtggagga agatctttga tgatgaacca     1020

actatcatta gaagagcttt ttactctttg ggcaattata ttgtggcctc cgaaatagct     1080

aaagaatctg ccaaatctcc tgtgattgta gacaggtccc agctgggagg aaccttatac     1140

catccttctc tccacctgct cggcagtgaa gtttgtggga ctggaatctt ggattcatca     1200

cactcgagtc aaggcctgga atgacccctg acatcccaga a                         1241


<210>  10
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Leu Leu Lys Ser Pro Pro Ser Cys Ile 
        275                 280                 285             


Gly Gln Trp Arg Lys Ile Phe Asp Asp Glu Pro Thr Ile Ile Arg Arg 
    290                 295                 300                 


Ala Phe Tyr Ser Leu Gly Asn Tyr Ile Val Ala Ser Glu Ile Ala Lys 
305                 310                 315                 320 


Glu Ser Ala Lys Ser Pro Val Ile Val Asp Arg Ser Gln Leu Gly Gly 
                325                 330                 335     


Thr Leu Tyr His Pro Ser Leu His Leu Leu Gly Ser Glu Val Cys Gly 
            340                 345                 350         


Thr Gly Ile Leu Asp Ser Ser His Ser Ser Gln Gly Leu Glu 
        355                 360                 365     


<210>  11
<211>  3014
<212>  DNA
<213>  Homo sapiens

<400>  11
aacgcttcgc tttcgtttcc cgctggcgcc tggctccctc cgggtttcgt ttcccgccgg       60

cgcctggctc ccgccaggtt tcgtttccga ggcggggccg agggcggcgt cgctgaggcg      120

cccatggcct tcgcccgccg gctcctgcgc gggccactgt cggggccgct gctcgggcgg      180

cgcggggtct gcgctggggc catggctccg ccgcgccgct tcgtcctgga gcttcccgac      240

tgcaccctgg ctcacttcgc cctaggcgcc gacgcccccg gcgacgcaga cgcccccgac      300

ccccgcctgg cggcgctgct ggggcccccg gagcgcagct actcgctgtg cgtgcccgtg      360

accccggacg ccggctgcgg ggcccgggtc cgggcggcgc ggctgcacca gcgcctgctg      420

caccagctgc gccgcggccc cttccagcgg tgccagctgc tcaggctgct ctgctactgc      480

ccgggcggcc aggccggcgg cgcacagcaa ggcttcctgc tgcgcgaccc cctggatgac      540

cctgacaccc ggcaagcgct gctcgagctg ctgggcgcct gtcaggaggc accacgcccg      600

cacttgggcg agttcgaggc cgacccgcgc ggccagctgt ggcagcgcct ctgggaggtg      660

caagacggca ggcggctgca ggtgggctgc gcacaggtcg tgcccgtccc ggagcccccg      720

ctgcacccgg tggtgccaga cttgcccagt tccgtggtct tcccggaccg ggaagccgcc      780

cgggccgttt tggaggagtg tacctccttt attcctgaag cccgggcagt gcttgacctg      840

gtcgaccagt gcccaaaaca gatccagaaa ggaaagttcc aggttgttgc catcgaagga      900

ctggatgcca cgggtaaaac cacggtgacc cagtcagtgg cagattcact taaggctgtc      960

ctcttaaagt caccaccctc ttgcattggc cagtggagga agatctttga tgatgaacca     1020

actatcatta gaagagcttt ttactctttg ggcaattata ttgtggcctc cgaaatagct     1080

aaagaatctg ccaaatctcc tgtgattgta gacaggtact ggcacagcac ggccacctat     1140

gccatagcca ctgaggtgag tgggggtctc cagcacctgc ccccagccca tcaccctgtg     1200

taccagtggc cagaggacct gctcaaacct gaccttatcc tgctgctcac tgtgagtcct     1260

gaggagaggt tgcagaggct gcagggccgg ggcatggaga agaccaggga agaagcagaa     1320

cttgaggcca acagtgtgtt tcgtcaaaag gtagaaatgt cctaccagcg gatggagaat     1380

cctggctgcc atgtggttga tgccagcccc tccagagaaa aggtcctgca gacggtatta     1440

agcctaatcc agaatagttt tagtgaaccg tagttactct ggccaggtgc cacgtctaac     1500

tagattagat gttgtttgaa acatctacat ccaccatttg ttatgcagtg ttcccaaatt     1560

tctgttctac aagcatgttg tgtggcagaa aactggagac caggcatctt aattttactt     1620

cagccatcgt accctcttct gactgatgga cccgtcatca caaaggtccc tctcatcatg     1680

ttccagtgag aggccagcga ttgctttctt cctggcatag taaacatttt cttggaacat     1740

atgtttcact taatcactac caaatatctg gaagacctgt cttactcaga cagcaccagg     1800

tgtacagaag cagcagacaa gatcttccag atcagcaggg agaccccgga gcctctgctt     1860

ctcctacact ggcatgctga tgagatcgtg acatgcccac attggcttct tccacatctg     1920

gttgcactcg tcatgatggg ctcgctgcat ctccctcagt cccaaattct agagccaagt     1980

gttcctgcag aggctgtcta tgtgtcctgg ctgcccaagg acactcctgc agagccattt     2040

ttgggtaagg aacacttaca aagaaggcat tgatcttgtg tctgaggctc agagcccttt     2100

tgataggctt ctgagtcata tataaagaca ttcaagccaa gatgctccaa ctgcaaatat     2160

accaaccttc tctgaattat attttgctta tttatatttc ttttcttttt ttctaaagta     2220

tggctctgaa tagaatgcac attttccatt gaactggatg catttcattt agccaatcca     2280

gtaatttatt tatattaatc tatacataat atgtttcctc agcataggag ctatgattca     2340

ttaattaaaa gtggagtcaa aacgctaaat gcaatgtttg ttgtgtattt tcattacaca     2400

aacttaattt gtcttgttaa ataagtacag tggatcttgg agtgggattt cttggtaaat     2460

tatcttgcac ttgaatgtct catgattaca tatgaaatcg ctttgacata tctttagaca     2520

gaaaaaagta gctgagtgag ggggaaatta tagagctgtg tgactttagg gagtaggttg     2580

aaccaggtga ttacctaaaa ttccttccag ttcaaaggca gataaatctg taaattattt     2640

tatcctatct accatttctt aagaagacat tactccaaaa taattaaatt taaggcttta     2700

tcaggtctgc atatagaatc ttaaattcta ataaagtttc atgttaatgt cataggattt     2760

ttaaaagagc tataggtaat ttctatataa tatgtgtata ttaaaatgta attgatttca     2820

gttgaaagta ttttaaagct gataaatagc attagggttc tttgcaatgt ggtatctagc     2880

tgtattattg gttttattta ctttaaacat tttgaaaagc ttatactggc agcctagaaa     2940

aacaaacaat taatgtatct ttatgtccct ggcacatgaa taaactttgc tgtggtttac     3000

taatctatgc tgtc                                                       3014


<210>  12
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Leu Leu Lys Ser Pro Pro Ser Cys Ile 
        275                 280                 285             


Gly Gln Trp Arg Lys Ile Phe Asp Asp Glu Pro Thr Ile Ile Arg Arg 
    290                 295                 300                 


Ala Phe Tyr Ser Leu Gly Asn Tyr Ile Val Ala Ser Glu Ile Ala Lys 
305                 310                 315                 320 


Glu Ser Ala Lys Ser Pro Val Ile Val Asp Arg Tyr Trp His Ser Thr 
                325                 330                 335     


Ala Thr Tyr Ala Ile Ala Thr Glu Val Ser Gly Gly Leu Gln His Leu 
            340                 345                 350         


Pro Pro Ala His His Pro Val Tyr Gln Trp Pro Glu Asp Leu Leu Lys 
        355                 360                 365             


Pro Asp Leu Ile Leu Leu Leu Thr Val Ser Pro Glu Glu Arg Leu Gln 
    370                 375                 380                 


Arg Leu Gln Gly Arg Gly Met Glu Lys Thr Arg Glu Glu Ala Glu Leu 
385                 390                 395                 400 


Glu Ala Asn Ser Val Phe Arg Gln Lys Val Glu Met Ser Tyr Gln Arg 
                405                 410                 415     


Met Glu Asn Pro Gly Cys His Val Val Asp Ala Ser Pro Ser Arg Glu 
            420                 425                 430         


Lys Val Leu Gln Thr Val Leu Ser Leu Ile Gln Asn Ser Phe Ser Glu 
        435                 440                 445             


Pro 
    


<210>  13
<211>  2286
<212>  DNA
<213>  Homo sapiens

<400>  13
agccccgatt ggctgtgacg cgcggccggg cgaggacccc gcccgcgccg ccgccgcgcc       60

cggcgctggg cggtcattgg gcggcgtgat ctcgccgcgg ttccgcggcc ctgccgccgc      120

cgccgccagc agagcgcacc gggccgatcg ggcgagtggc catggcgggc gccgaggact      180

ggccgggcca gcagctggag ctggacgagg acgaggcgtc ttgttgccgc tggggcgcgc      240

agcacgccgg ggcccgcgag ctggctgcgc tctactcgcc aggcaagcgc ctccaggagt      300

ggtgctctgt gatcctgtgc ttcagcctca tcgcccacaa cctggtccat ctcctgctgc      360

tggcccgctg ggaggacaca cccctcgtca tactcggtgt tgttgcaggg gctctcattg      420

ctgacttctt gtctggcctg gtacactggg gtgctgacac atggggctct gtggagctgc      480

ccattgcttt catccgaccc ttccgggagc accacattga cccgacagct atcacacggc      540

acgacttcat cgagaccaac ggggacaact gcctggtgac actgctgccg ctgctaaaca      600

tggcctacaa gttccgcacc cacagccctg aagccctgga gcagctatac ccctgggagt      660

gcttcgtctt ctgcctgatc atcttcggca ccttcaccaa ccagatccac aagtggtcgc      720

acacgtactt tgggctgcca cgctgggtca ccctcctgca ggactggcat gtcatcctgc      780

cacgtaaaca ccatcgcatc caccacgtct caccccacga gacctacttc tgcatcacca      840

caggctggct caactaccct ctggagaaga taggcttctg gcgacgcctg gaggacctca      900

tccagggcct gacgggcgag aagcctcggg cagatgacat gaaatgggcc cagaagatca      960

aataacttct ccgagcctgc tacctggttg ccaaccttcc ctagccccca aaccgaagcc     1020

atctgccaaa ttccagcctc tttgagctgg cccctccaga tggagaggac atctcctggg     1080

ctgggcccag gtaccccagc ccacccctca tgacacagaa tacttgagcc actgattttt     1140

catttctttt tttttttttt cctcggcccc tcctcagcca cctgagttgc tctatctgca     1200

agcctgactc tgccagcctc ccctggtaga gaggaggttt acccactccc tgcacgcctg     1260

ccgtccctgc cccgctgggc agcccttcag tgtggctggc gttggggcca gtgagttgcc     1320

tctttccctc cttgtctggc cccagtggtc tggggagccc ccaggcacac ctaagcgtcg     1380

tggagcattg ttctgccaca gccctgcata ctgaccccgg gaggctgggc aggtggacag     1440

ccccagccac caccttcagc ctagcctgtc ccccaaggat ggtgaagctc agcaggggtc     1500

tgagggtagc cggccagaag aggctggaac ctcctgctca agtctagacc cctacttctc     1560

tgctgccccc accctgccag agctgatgtt tccaatacca agatgtcttc acagggcaca     1620

gcccctgcag agcatcttgg tcatttggaa gaggacacgg tatcccctct ggccagagta     1680

tgtcagagaa ggaagagtag ggcttttttg ttttgttttt ttttaaaggt gcttgcttgt     1740

ttaatgtaaa taatagaaag ccttaatatc ttttctgtaa cacggagtaa tattttaatg     1800

tcatgttttg gatgtacata atatatttat aacaaagcag caagagtcta cttaaccttg     1860

gctgcctcgt ggtgtttcct ggctgggtgg ggtggggggt atcaaggagc ctgggacgtg     1920

aggccccact ctcgccccat tcccagctcc ccccaaccct ggcctcagga tgagagctgt     1980

cacctgagac agtgaattaa tgttgacatc tgctccaaag ccttttggag gggattgggt     2040

gaggacagtg gtctttcctg ttgatcatga tgataaagta atgatggctg atccctattt     2100

gtgacttcct tcagcaaata ttcactggca cctggtgtgt gccaggctct gtcctgtaca     2160

caggtacagc ggtgaaagaa ccaacaaaga cctatcctgg tggagctgac ctcctgggaa     2220

aagagtcaat aaacaaataa atgcacatgg aaattcaggt ggtgatttgt gaagaaaatc     2280

aaacag                                                                2286


<210>  14
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Ala Glu Asp Trp Pro Gly Gln Gln Leu Glu Leu Asp Glu 
1               5                   10                  15      


Asp Glu Ala Ser Cys Cys Arg Trp Gly Ala Gln His Ala Gly Ala Arg 
            20                  25                  30          


Glu Leu Ala Ala Leu Tyr Ser Pro Gly Lys Arg Leu Gln Glu Trp Cys 
        35                  40                  45              


Ser Val Ile Leu Cys Phe Ser Leu Ile Ala His Asn Leu Val His Leu 
    50                  55                  60                  


Leu Leu Leu Ala Arg Trp Glu Asp Thr Pro Leu Val Ile Leu Gly Val 
65                  70                  75                  80  


Val Ala Gly Ala Leu Ile Ala Asp Phe Leu Ser Gly Leu Val His Trp 
                85                  90                  95      


Gly Ala Asp Thr Trp Gly Ser Val Glu Leu Pro Ile Ala Phe Ile Arg 
            100                 105                 110         


Pro Phe Arg Glu His His Ile Asp Pro Thr Ala Ile Thr Arg His Asp 
        115                 120                 125             


Phe Ile Glu Thr Asn Gly Asp Asn Cys Leu Val Thr Leu Leu Pro Leu 
    130                 135                 140                 


Leu Asn Met Ala Tyr Lys Phe Arg Thr His Ser Pro Glu Ala Leu Glu 
145                 150                 155                 160 


Gln Leu Tyr Pro Trp Glu Cys Phe Val Phe Cys Leu Ile Ile Phe Gly 
                165                 170                 175     


Thr Phe Thr Asn Gln Ile His Lys Trp Ser His Thr Tyr Phe Gly Leu 
            180                 185                 190         


Pro Arg Trp Val Thr Leu Leu Gln Asp Trp His Val Ile Leu Pro Arg 
        195                 200                 205             


Lys His His Arg Ile His His Val Ser Pro His Glu Thr Tyr Phe Cys 
    210                 215                 220                 


Ile Thr Thr Gly Trp Leu Asn Tyr Pro Leu Glu Lys Ile Gly Phe Trp 
225                 230                 235                 240 


Arg Arg Leu Glu Asp Leu Ile Gln Gly Leu Thr Gly Glu Lys Pro Arg 
                245                 250                 255     


Ala Asp Asp Met Lys Trp Ala Gln Lys Ile Lys 
            260                 265         


<210>  15
<211>  2295
<212>  DNA
<213>  Homo sapiens

<400>  15
agccccgatt ggctgtgacg cgcggccggg cgaggacccc gcccgcgccg ccgccgcgcc       60

cggcgctggg cggtcattgg gcggcgtgat ctcgccgcgg ttccgcggcc ctgccgccgc      120

cgccgccagc agagcgcacc gggccgatcg ggcgagtggc catggcgggc gccgaggact      180

ggccgggcca gcagctggag ctggacgagg acgaggcgtc ttgttgccgc tggggcgcgc      240

agcacgccgg ggcccgcgag ctggctgcgc tctactcgcc aggcaagcgc ctccaggagt      300

ggtgctctgt gatcctgtgc ttcagcctca tcgcccacaa cctggtccat ctcctgctgc      360

tggcccgctg ggaggacaca cccctcgtca tactcggtgt tgttgcaggg gctctcattg      420

ctgacttctt gtctggcctg gtacactggg gtgctgacac atggggctct gtggagctgc      480

ccattgtggg gaaggctttc atccgaccct tccgggagca ccacattgac ccgacagcta      540

tcacacggca cgacttcatc gagaccaacg gggacaactg cctggtgaca ctgctgccgc      600

tgctaaacat ggcctacaag ttccgcaccc acagccctga agccctggag cagctatacc      660

cctgggagtg cttcgtcttc tgcctgatca tcttcggcac cttcaccaac cagatccaca      720

agtggtcgca cacgtacttt gggctgccac gctgggtcac cctcctgcag gactggcatg      780

tcatcctgcc acgtaaacac catcgcatcc accacgtctc accccacgag acctacttct      840

gcatcaccac aggctggctc aactaccctc tggagaagat aggcttctgg cgacgcctgg      900

aggacctcat ccagggcctg acgggcgaga agcctcgggc agatgacatg aaatgggccc      960

agaagatcaa ataacttctc cgagcctgct acctggttgc caaccttccc tagcccccaa     1020

accgaagcca tctgccaaat tccagcctct ttgagctggc ccctccagat ggagaggaca     1080

tctcctgggc tgggcccagg taccccagcc cacccctcat gacacagaat acttgagcca     1140

ctgatttttc atttcttttt tttttttttc ctcggcccct cctcagccac ctgagttgct     1200

ctatctgcaa gcctgactct gccagcctcc cctggtagag aggaggttta cccactccct     1260

gcacgcctgc cgtccctgcc ccgctgggca gcccttcagt gtggctggcg ttggggccag     1320

tgagttgcct ctttccctcc ttgtctggcc ccagtggtct ggggagcccc caggcacacc     1380

taagcgtcgt ggagcattgt tctgccacag ccctgcatac tgaccccggg aggctgggca     1440

ggtggacagc cccagccacc accttcagcc tagcctgtcc cccaaggatg gtgaagctca     1500

gcaggggtct gagggtagcc ggccagaaga ggctggaacc tcctgctcaa gtctagaccc     1560

ctacttctct gctgccccca ccctgccaga gctgatgttt ccaataccaa gatgtcttca     1620

cagggcacag cccctgcaga gcatcttggt catttggaag aggacacggt atcccctctg     1680

gccagagtat gtcagagaag gaagagtagg gcttttttgt tttgtttttt tttaaaggtg     1740

cttgcttgtt taatgtaaat aatagaaagc cttaatatct tttctgtaac acggagtaat     1800

attttaatgt catgttttgg atgtacataa tatatttata acaaagcagc aagagtctac     1860

ttaaccttgg ctgcctcgtg gtgtttcctg gctgggtggg gtggggggta tcaaggagcc     1920

tgggacgtga ggccccactc tcgccccatt cccagctccc cccaaccctg gcctcaggat     1980

gagagctgtc acctgagaca gtgaattaat gttgacatct gctccaaagc cttttggagg     2040

ggattgggtg aggacagtgg tctttcctgt tgatcatgat gataaagtaa tgatggctga     2100

tccctatttg tgacttcctt cagcaaatat tcactggcac ctggtgtgtg ccaggctctg     2160

tcctgtacac aggtacagcg gtgaaagaac caacaaagac ctatcctggt ggagctgacc     2220

tcctgggaaa agagtcaata aacaaataaa tgcacatgga aattcaggtg gtgatttgtg     2280

aagaaaatca aacag                                                      2295


<210>  16
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gly Ala Glu Asp Trp Pro Gly Gln Gln Leu Glu Leu Asp Glu 
1               5                   10                  15      


Asp Glu Ala Ser Cys Cys Arg Trp Gly Ala Gln His Ala Gly Ala Arg 
            20                  25                  30          


Glu Leu Ala Ala Leu Tyr Ser Pro Gly Lys Arg Leu Gln Glu Trp Cys 
        35                  40                  45              


Ser Val Ile Leu Cys Phe Ser Leu Ile Ala His Asn Leu Val His Leu 
    50                  55                  60                  


Leu Leu Leu Ala Arg Trp Glu Asp Thr Pro Leu Val Ile Leu Gly Val 
65                  70                  75                  80  


Val Ala Gly Ala Leu Ile Ala Asp Phe Leu Ser Gly Leu Val His Trp 
                85                  90                  95      


Gly Ala Asp Thr Trp Gly Ser Val Glu Leu Pro Ile Val Gly Lys Ala 
            100                 105                 110         


Phe Ile Arg Pro Phe Arg Glu His His Ile Asp Pro Thr Ala Ile Thr 
        115                 120                 125             


Arg His Asp Phe Ile Glu Thr Asn Gly Asp Asn Cys Leu Val Thr Leu 
    130                 135                 140                 


Leu Pro Leu Leu Asn Met Ala Tyr Lys Phe Arg Thr His Ser Pro Glu 
145                 150                 155                 160 


Ala Leu Glu Gln Leu Tyr Pro Trp Glu Cys Phe Val Phe Cys Leu Ile 
                165                 170                 175     


Ile Phe Gly Thr Phe Thr Asn Gln Ile His Lys Trp Ser His Thr Tyr 
            180                 185                 190         


Phe Gly Leu Pro Arg Trp Val Thr Leu Leu Gln Asp Trp His Val Ile 
        195                 200                 205             


Leu Pro Arg Lys His His Arg Ile His His Val Ser Pro His Glu Thr 
    210                 215                 220                 


Tyr Phe Cys Ile Thr Thr Gly Trp Leu Asn Tyr Pro Leu Glu Lys Ile 
225                 230                 235                 240 


Gly Phe Trp Arg Arg Leu Glu Asp Leu Ile Gln Gly Leu Thr Gly Glu 
                245                 250                 255     


Lys Pro Arg Ala Asp Asp Met Lys Trp Ala Gln Lys Ile Lys 
            260                 265                 270 


<210>  17
<211>  1742
<212>  DNA
<213>  Homo sapiens

<400>  17
tctttgaagc ttcaaggctg ctgaataatt tccttctccc attttgtgcc tgcctagcta       60

tccagacaga gcagctaccc tcagctctag ctgatactac agacagtaca acagatcaag      120

aagtatggca gtgacaactc gtttgacatg gttgcacgaa aagatcctgc aaaatcattt      180

tggagggaag cggcttagcc ttctctataa gggtagtgtc catggattcc gtaatggagt      240

tttgcttgac agatgttgta atcaagggcc tactctaaca gtgatttata gtgaagatca      300

tattattgga gcatatgcag aagagagtta ccaggaagga aagtatgctt ccatcatcct      360

ttttgcactt caagatacta aaatttcaga atggaaacta ggactatgta caccagaaac      420

actgttttgt tgtgatgtta caaaatataa ctccccaact aatttccaga tagatggaag      480

aaatagaaaa gtgattatgg acttaaagac aatggaaaat cttggacttg ctcaaaattg      540

tactatctct attcaggatt atgaagtttt tcgatgcgaa gattcactgg atgaaagaaa      600

gataaaaggg gtcattgagc tcaggaagag cttactgtct gccttgagaa cttatgaacc      660

atatggatcc ctggttcaac aaatacgaat tctgctgctg ggtccaattg gagctgggaa      720

gtccagcttt ttcaactcag tgaggtctgt tttccaaggg catgtaacgc atcaggcttt      780

ggtgggcact aatacaactg ggatatctga gaagtatagg acatactcta ttagagacgg      840

gaaagatggc aaatacctgc cgtttattct gtgtgactca ctggggctga gtgagaaaga      900

aggcggcctg tgcagggatg acatattcta tatcttgaac ggtaacattc gtgatagata      960

ccagtttaat cccatggaat caatcaaatt aaatcatcat gactacattg attccccatc     1020

gctgaaggac agaattcatt gtgtggcatt tgtatttgat gccagctcta ttcaatactt     1080

ctcctctcag atgatagtaa agatcaaaag aattcgaagg gagttggtaa acgctggtgt     1140

ggtacatgtg gctttgctca ctcatgtgga tagcatggat ttgattacaa aaggtgacct     1200

tatagaaata gagagatgtg agcctgtgag gtccaagcta gaggaagtcc aaagaaaact     1260

tggatttgct ctttctgaca tctcggtggt tagcaattat tcctctgagt gggagctgga     1320

ccctgtaaag gatgttctaa ttctttctgc tctgagacga atgctatggg ctgcagatga     1380

cttcttagag gatttgcctt ttgagcaaat agggaatcta agggaggaaa ttatcaactg     1440

tgcacaagga aaaaaataga tatgtgaaag gttcacgtaa atttcctcac atcacagaag     1500

attaaaattc agaaaggaga aaacacagac caaagagaag tatctaagac caaagggatg     1560

tgttttatta atgtctagga tgaagaaatg catagaacat tgtagtactt gtaaataact     1620

agaaataaca tgatttagtc ataattgtga aaaataataa taatttttct tggatttatg     1680

ttctgtatct gtgaaaaaat aaatttctta taaaactcgg gtctaaaaaa aaaaaaaaaa     1740

aa                                                                    1742


<210>  18
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210>  19
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  19
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag       60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct      120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag      180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct      240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg      300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt      360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa      420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc      480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata      540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt      600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat      660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca      720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag      780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga      840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg      900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga      960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca     1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa     1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt     1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc     1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga     1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct     1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa     1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat     1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg     1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct     1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa     1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt     1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata     1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc     1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt     1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat     1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc     1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc     2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg     2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa     2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca     2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag     2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt     2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca     2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc     2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa     2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg     2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta     2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag     2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc     2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg     2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa     2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata     2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc     3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac     3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat     3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag     3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca     3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga     3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca     3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt     3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta     3480

atgtaaagtg aaataaaact ataagctatg tt                                   3512


<210>  20
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  21
<211>  3050
<212>  DNA
<213>  Homo sapiens

<400>  21
ggagtcagtg atttgaacga agtactttca gtttcatatt actctaaatc cattacaaat       60

ctgcttagct tctaaatatt tcatcaatga ggaaatccca gccctacaac ttcggaacag      120

tgaaatatta gtccagggat ccagtgagag acacagaagt gctagaagcc agtgctcgtg      180

aactaaggag aaaaagaaca gacaagggaa cagcctggac atggcatcag agatccacat      240

gacaggccca atgtgcctca ttgagaacac taatgggcga ctgatggcga atccagaagc      300

tctgaagatc ctttctgcca ttacacagcc tatggtggtg gtggcaattg tgggcctcta      360

ccgcacaggc aaatcctacc tgatgaacaa gctggctgga aagaaaaagg gcttctctct      420

gggctccacg gtgcagtctc acactaaagg aatctggatg tggtgtgtgc cccaccccaa      480

gaagccaggc cacatcctag ttctgctgga caccgagggt ctgggagatg tagagaaggg      540

tgacaaccag aatgactcct ggatcttcgc cctggccgtc ctcctgagca gcaccttcgt      600

gtacaatagc ataggaacca tcaaccagca ggctatggac caactgtact atgtgacaga      660

gctgacacat agaatccgat caaaatcctc acctgatgag aatgagaatg aggttgagga      720

ttcagctgac tttgtgagct tcttcccaga ctttgtgtgg acactgagag atttctccct      780

ggacttggaa gcagatggac aacccctcac accagatgag tacctgacat actccctgaa      840

gctgaagaaa ggtaccagtc aaaaagatga aacttttaac ctgcccagac tctgtatccg      900

gaaattcttc ccaaagaaaa aatgctttgt ctttgatcgg cccgttcacc gcaggaagct      960

tgcccagctc gagaaactac aagatgaaga gctggacccc gaatttgtgc aacaagtagc     1020

agacttctgt tcctacatct ttagtaattc caaaactaaa actctttcag gaggcatcca     1080

ggtcaacggg cctcgtctag agagcctggt gctgacctac gtcaatgcca tcagcagtgg     1140

ggatctgccg tgcatggaga acgcagtcct ggccttggcc cagatagaga actcagctgc     1200

agtgcaaaag gctattgccc actatgaaca gcagatgggc cagaaggtgc agctgcccac     1260

agaaaccctc caggagctgc tggacctgca cagggacagt gagagagagg ccattgaagt     1320

cttcatcagg agttccttca aagatgtgga ccatctattt caaaaggagt tagcggccca     1380

gctagaaaaa aagcgggatg acttttgtaa acagaatcag gaagcatcat cagatcgttg     1440

ctcagcttta cttcaggtca ttttcagtcc tctagaagaa gaagtgaagg cgggaattta     1500

ttcgaaacca gggggctatc gtctctttgt tcagaagcta caagacctga agaaaaagta     1560

ctatgaggaa ccgaggaagg ggatacaggc tgaagagatt ctgcagacat acttgaaatc     1620

caaggagtct atgactgatg caattctcca gacagaccag actctcacag aaaaagaaaa     1680

ggagattgaa gtggaacgtg tgaaagctga gtctgcacag gcttcagcaa aaatgttgca     1740

ggaaatgcaa agaaagaatg agcagatgat ggaacagaag gagaggagtt atcaggaaca     1800

cttgaaacaa ctgactgaga agatggagaa cgacagggtc cagttgctga aagagcaaga     1860

gaggaccctc gctcttaaac ttcaggaaca ggagcaacta ctaaaagagg gatttcaaaa     1920

agaaagcaga ataatgaaaa atgagataca ggatctccag acgaaaatga gacgacgaaa     1980

ggcatgtacc ataagctaaa gaccagagcc ttcctgtcac ccctaaccaa ggcataattg     2040

aaacaatttt agaatttgga acaagcgtca ctacatttga taataattag atcttgcatc     2100

ataacaccaa aagtttataa aggcatgtgg tacaatgatc aaaatcatgt tttttcttaa     2160

aaaaaaaaaa agactgtaaa ttgtgcaaca aagatgcatt tacctctgta tcaactcagg     2220

aaatctcata agctggtacc actcaggaga agtttattct tccagatgac cagcagtaga     2280

caaatggata ctgagcagag tcttaggtaa aagtcttggg aaatatttgg gcattggtct     2340

ggccaagtct acaatgtccc aatatcaagg acaaccaccc tagcttctta gtgaagacaa     2400

tgtacagtta tccgttagat caagactaca cggtctatga gcaataatgt gatttctgga     2460

cattgcccat gtataatcct cactgatgat ttcaagctaa agcaaaccac cttatacaga     2520

gatctagaat ctctttatgt tctccagagg aaggtggaag aaaccatggg caggagtagg     2580

aattgagtga taaacaattg ggctaatgaa gaaaacttct cttattgttc agttcatcca     2640

gattataact tcaatgggac actttagacc attagacaat tgacactgga ttaaacaaat     2700

tcacataatg ccaaatacac aatgtattta tagcaacgta taatttgcaa agatggactt     2760

taaaagatgc tgtgtaacta aactgaaata attcaattac ttattattta gaatgttaaa     2820

gcttatgata gtcttttcta actcttaaca ctcatacttg aaaactttct gagtttcccc     2880

agaagagaat atgggatttt ttttgacatt tttgactcat ttaataatgc tcttgtgttt     2940

acctagtata tgtagacttt gtcttatgtg tgaaaagtcc taggaaagtg gttgatgttt     3000

cttatagcaa ttaaaaatta tttttgaact gaaaatacaa tgtatttcac                3050


<210>  22
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ser Glu Ile His Met Thr Gly Pro Met Cys Leu Ile Glu Asn 
1               5                   10                  15      


Thr Asn Gly Arg Leu Met Ala Asn Pro Glu Ala Leu Lys Ile Leu Ser 
            20                  25                  30          


Ala Ile Thr Gln Pro Met Val Val Val Ala Ile Val Gly Leu Tyr Arg 
        35                  40                  45              


Thr Gly Lys Ser Tyr Leu Met Asn Lys Leu Ala Gly Lys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Leu Gly Ser Thr Val Gln Ser His Thr Lys Gly Ile Trp Met 
65                  70                  75                  80  


Trp Cys Val Pro His Pro Lys Lys Pro Gly His Ile Leu Val Leu Leu 
                85                  90                  95      


Asp Thr Glu Gly Leu Gly Asp Val Glu Lys Gly Asp Asn Gln Asn Asp 
            100                 105                 110         


Ser Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Thr Phe Val Tyr 
        115                 120                 125             


Asn Ser Ile Gly Thr Ile Asn Gln Gln Ala Met Asp Gln Leu Tyr Tyr 
    130                 135                 140                 


Val Thr Glu Leu Thr His Arg Ile Arg Ser Lys Ser Ser Pro Asp Glu 
145                 150                 155                 160 


Asn Glu Asn Glu Val Glu Asp Ser Ala Asp Phe Val Ser Phe Phe Pro 
                165                 170                 175     


Asp Phe Val Trp Thr Leu Arg Asp Phe Ser Leu Asp Leu Glu Ala Asp 
            180                 185                 190         


Gly Gln Pro Leu Thr Pro Asp Glu Tyr Leu Thr Tyr Ser Leu Lys Leu 
        195                 200                 205             


Lys Lys Gly Thr Ser Gln Lys Asp Glu Thr Phe Asn Leu Pro Arg Leu 
    210                 215                 220                 


Cys Ile Arg Lys Phe Phe Pro Lys Lys Lys Cys Phe Val Phe Asp Arg 
225                 230                 235                 240 


Pro Val His Arg Arg Lys Leu Ala Gln Leu Glu Lys Leu Gln Asp Glu 
                245                 250                 255     


Glu Leu Asp Pro Glu Phe Val Gln Gln Val Ala Asp Phe Cys Ser Tyr 
            260                 265                 270         


Ile Phe Ser Asn Ser Lys Thr Lys Thr Leu Ser Gly Gly Ile Gln Val 
        275                 280                 285             


Asn Gly Pro Arg Leu Glu Ser Leu Val Leu Thr Tyr Val Asn Ala Ile 
    290                 295                 300                 


Ser Ser Gly Asp Leu Pro Cys Met Glu Asn Ala Val Leu Ala Leu Ala 
305                 310                 315                 320 


Gln Ile Glu Asn Ser Ala Ala Val Gln Lys Ala Ile Ala His Tyr Glu 
                325                 330                 335     


Gln Gln Met Gly Gln Lys Val Gln Leu Pro Thr Glu Thr Leu Gln Glu 
            340                 345                 350         


Leu Leu Asp Leu His Arg Asp Ser Glu Arg Glu Ala Ile Glu Val Phe 
        355                 360                 365             


Ile Arg Ser Ser Phe Lys Asp Val Asp His Leu Phe Gln Lys Glu Leu 
    370                 375                 380                 


Ala Ala Gln Leu Glu Lys Lys Arg Asp Asp Phe Cys Lys Gln Asn Gln 
385                 390                 395                 400 


Glu Ala Ser Ser Asp Arg Cys Ser Ala Leu Leu Gln Val Ile Phe Ser 
                405                 410                 415     


Pro Leu Glu Glu Glu Val Lys Ala Gly Ile Tyr Ser Lys Pro Gly Gly 
            420                 425                 430         


Tyr Arg Leu Phe Val Gln Lys Leu Gln Asp Leu Lys Lys Lys Tyr Tyr 
        435                 440                 445             


Glu Glu Pro Arg Lys Gly Ile Gln Ala Glu Glu Ile Leu Gln Thr Tyr 
    450                 455                 460                 


Leu Lys Ser Lys Glu Ser Met Thr Asp Ala Ile Leu Gln Thr Asp Gln 
465                 470                 475                 480 


Thr Leu Thr Glu Lys Glu Lys Glu Ile Glu Val Glu Arg Val Lys Ala 
                485                 490                 495     


Glu Ser Ala Gln Ala Ser Ala Lys Met Leu Gln Glu Met Gln Arg Lys 
            500                 505                 510         


Asn Glu Gln Met Met Glu Gln Lys Glu Arg Ser Tyr Gln Glu His Leu 
        515                 520                 525             


Lys Gln Leu Thr Glu Lys Met Glu Asn Asp Arg Val Gln Leu Leu Lys 
    530                 535                 540                 


Glu Gln Glu Arg Thr Leu Ala Leu Lys Leu Gln Glu Gln Glu Gln Leu 
545                 550                 555                 560 


Leu Lys Glu Gly Phe Gln Lys Glu Ser Arg Ile Met Lys Asn Glu Ile 
                565                 570                 575     


Gln Asp Leu Gln Thr Lys Met Arg Arg Arg Lys Ala Cys Thr Ile Ser 
            580                 585                 590         


<210>  23
<211>  8394
<212>  DNA
<213>  Homo sapiens

<400>  23
atggaattcc ccattggatc cctcgaaact aacaacttcc gtcgctttac tccggagtca       60

ctggtggaga tagagaagca aattgctgcc aagcagggaa caaagaaagc cagagagaag      120

catagggagc agaaggacca agaagagaag cctcggcccc agctggactt gaaagcctgc      180

aaccagctgc ccaagttcta tggtgagctc ccagcagaac tgatcgggga gcccctggag      240

gatctagatc cgttctacag cacacaccgg acatttatgg tgctgaacaa agggaggacc      300

atttcccggt ttagtgccac tcgggccctg tggctattca gtcctttcaa cctgatcaga      360

agaacggcca tcaaagtgtc tgtccactcg tggttcagtt tatttattac ggtcactatt      420

ttggttaatt gtgtgtgcat gacccgaact gaccttccag agaaaattga atatgtcttc      480

actgtcattt acacctttga agccttgata aagatactgg caagaggatt ttgtctaaat      540

gagttcacgt acctgagaga tccttggaac tggctggatt ttagcgtcat taccctggca      600

tatgttggca cagcaataga tctccgtggg atctcaggcc tgcggacatt cagagttctt      660

agagcattaa aaacagtttc tgtgatccca ggcctgaagg tcattgtggg ggccctgatt      720

cactcagtga agaaactggc tgatgtgacc atcctcacca tcttctgcct aagtgttttt      780

gccttggtgg ggctgcaact cttcaagggc aacctcaaaa ataaatgtgt caagaatgac      840

atggctgtca atgagacaac caactactca tctcacagaa aaccagatat ctacataaat      900

aagcgaggca cttctgaccc cttactgtgt ggcaatggat ctgactcagg ccactgccct      960

gatggttata tctgccttaa aacttctgac aacccggatt ttaactacac cagctttgat     1020

tcctttgctt gggctttcct ctcactgttc cgcctcatga cacaggattc ctgggaacgc     1080

ctctaccagc agaccctgag gacttctggg aaaatctata tgatcttttt tgtgctcgta     1140

atcttcctgg gatctttcta cctggtcaac ttgatcttgg ctgtagtcac catggcgtat     1200

gaggagcaga accaggcaac cactgatgaa attgaagcaa aggagaagaa gttccaggag     1260

gccctcgaga tgctccggaa ggagcaggag gtgctagcag cactagggat tgacacaacc     1320

tctctccact cccacaatgg atcaccttta acctccaaaa atgccagtga gagaaggcat     1380

agaataaagc caagagtgtc agagggctcc acagaagaca acaaatcacc ccgctctgat     1440

ccttacaacc agcgcaggat gtcttttcta ggcctcgcct ctggaaaacg ccgggctagt     1500

catggcagtg tgttccattt ccggtcccct ggccgagata tctcactccc tgagggagtc     1560

acagatgatg gagtctttcc tggagaccac gaaagccatc ggggctctct gctgctgggt     1620

gggggtgctg gccagcaagg ccccctccct agaagccctc ttcctcaacc cagcaaccct     1680

gactccaggc atggagaaga tgaacaccaa ccgccgccca ctagtgagct tgcccctgga     1740

gctgtcgatg tctcggcatt cgatgcagga caaaagaaga ctttcttgtc agcagaatac     1800

ttagatgaac ctttccgggc ccaaagggca atgagtgttg tcagtatcat aacctccgtc     1860

cttgaggaac tcgaggagtc tgaacagaag tgcccaccct gcttgaccag cttgtctcag     1920

aagtatctga tctgggattg ctgccccatg tgggtgaagc tcaagacaat tctctttggg     1980

cttgtgacgg atccctttgc agagctcacc atcaccttgt gcatcgtggt gaacaccatc     2040

ttcatggcca tggagcacca tggcatgagc cctaccttcg aagccatgct ccagataggc     2100

aacatcgtct ttaccatatt ttttactgct gaaatggtct tcaaaatcat tgccttcgac     2160

ccatactatt atttccagaa gaagtggaat atctttgact gcatcatcgt cactgtgagt     2220

ctgctagagc tgggcgtggc caagaaggga agcctgtctg tgctgcggag cttccgcttg     2280

ctgcgcgtat tcaagctggc caaatcctgg cccaccttaa acacactcat caagatcatc     2340

ggaaactcag tgggggcact ggggaacctc accatcatcc tggccatcat tgtctttgtc     2400

tttgctctgg ttggcaagca gctcctaggg gaaaactacc gtaacaaccg aaaaaatatc     2460

tccgcgcccc atgaagactg gccccgctgg cacatgcacg acttcttcca ctctttcctc     2520

attgtcttcc gtatcctctg tggagagtgg attgagaaca tgtgggcctg catggaagtt     2580

ggccaaaaat ccatatgcct catccttttc ttgacggtga tggtgctagg gaacctggtg     2640

gtgcttaacc tgttcatcgc cctgctattg aactctttca gtgctgacaa cctcacagcc     2700

ccggaggacg atggggaggt gaacaacctg caggtggccc tggcacggat ccaggtcttt     2760

ggccatcgta ccaaacaggc tctttgcagc ttcttcagca ggtcctgccc attcccccag     2820

cccaaggcag agcctgagct ggtggtgaaa ctcccactct ccagctccaa ggctgagaac     2880

cacattgctg ccaacactgc cagggggagc tctggagggc tccaagctcc cagaggcccc     2940

agggatgagc acagtgactt catcgctaat ccgactgtgt gggtctctgt gcccattgct     3000

gagggtgaat ctgatcttga tgacttggag gatgatggtg gggaagatgc tcagagcttc     3060

cagcaggaag tgatccccaa aggacagcag gagcagctgc agcaagtcga gaggtgtggg     3120

gaccacctga cacccaggag cccaggcact ggaacatctt ctgaggacct ggctccatcc     3180

ctgggtgaga cgtggaaaga tgagtctgtt cctcaggtcc ctgctgaggg agtggacgac     3240

acaagctcct ctgagggcag cacggtggac tgcctagatc ctgaggaaat cctgaggaag     3300

atccctgagc tggcagatga cctggaagaa ccagatgact gcttcacaga aggatgcatt     3360

cgccactgtc cctgctgcaa actggatacc accaagagtc catgggatgt gggctggcag     3420

gtgcgcaaga cttgctaccg tatcgtggag cacagctggt ttgagagctt catcatcttc     3480

atgatcctgc tcagcagtgg atctctggcc tttgaagact attacctgga ccagaagccc     3540

acggtgaaag ctttgctgga gtacactgac agggtcttca cctttatctt tgtgttcgag     3600

atgctgctta agtgggtggc ctatggcttc aaaaagtact tcaccaatgc ctggtgctgg     3660

ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat     3720

tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct     3780

ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc     3840

atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg     3900

aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt     3960

gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc     4020

ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt     4080

ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg     4140

gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc     4200

ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac     4260

ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag     4320

aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg     4380

cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc     4440

accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa     4500

agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca     4560

ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat     4620

gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt     4680

aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt     4740

ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc     4800

atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc     4860

tactctatct tcggtatgtc cagctttccc catgtgaggt tcaccaatgc ctggtgctgg     4920

ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat     4980

tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct     5040

ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc     5100

atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg     5160

aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt     5220

gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc     5280

ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt     5340

ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg     5400

gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc     5460

ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac     5520

ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag     5580

aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg     5640

cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc     5700

accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa     5760

agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca     5820

ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat     5880

gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt     5940

aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt     6000

ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc     6060

atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc     6120

tactctatct tcggtatgtc cagctttccc catgtgaggt tcaccaatgc ctggtgctgg     6180

ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat     6240

tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct     6300

ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc     6360

atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg     6420

aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt     6480

gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc     6540

ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt     6600

ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg     6660

gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc     6720

ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac     6780

ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag     6840

aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg     6900

cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc     6960

accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa     7020

agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca     7080

ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat     7140

gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt     7200

aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt     7260

ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc     7320

atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc     7380

tactctatct tcggtatgtc cagctttccc catgtgaggt gggaggctgg catcgacgac     7440

atgttcaact tccagacctt cgccaacagc atgctgtgcc tcttccagat taccacgtcg     7500

gccggctggg atggcctcct cagccccatc ctcaacacag ggccccccta ctgtgacccc     7560

aatctgccca acagcaatgg caccagaggg gactgtggga gcccagccgt aggcatcatc     7620

ttcttcacca cctacatcat catctccttc ctcatcatgg tcaacatgta cattgcagtg     7680

attctggaga acttcaatgt ggccacggag gagagcactg agcccctgag tgaggacgac     7740

tttgacatgt tctatgagac ctgggagaag tttgacccag aggccactca gtttattacc     7800

ttttctgctc tctcggactt tgcagacact ctctctggtc ccctgagaat cccaaaaccc     7860

aatcgaaata tactgatcca gatggacctg cctttggtcc ctggagataa gatccactgc     7920

ttggacatcc tttttgcttt caccaagaat gtcctaggag aatccgggga gttggattct     7980

ctgaaggcaa atatggagga gaagtttatg gcaactaatc tttcaaaatc atcctatgaa     8040

ccaatagcaa ccactctccg atggaagcaa gaagacattt cagccactgt cattcaaaag     8100

gcctatcgga gctatgtgct gcaccgctcc atggcactct ctaacacccc atgtgtgccc     8160

agagctgagg aggaggctgc atcactccca gatgaaggtt ttgttgcatt cacagcaaat     8220

gaaaattgtg tactcccaga caaatctgaa actgcttctg ccacatcatt cccaccgtcc     8280

tatgagagtg tcactagagg ccttagtgat agagtcaaca tgaggacatc tagctcaata     8340

caaaatgaag atgaagccac cagtatggag ctgattgccc ctgggcccta gtga           8394


<210>  24
<211>  1956
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe 
1               5                   10                  15      


Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln 
            20                  25                  30          


Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu 
        35                  40                  45              


Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro 
    50                  55                  60                  


Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu 
65                  70                  75                  80  


Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn 
                85                  90                  95      


Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu 
            100                 105                 110         


Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val 
        115                 120                 125             


His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr Ile Leu Val Asn Cys 
    130                 135                 140                 


Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe 
145                 150                 155                 160 


Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly 
                165                 170                 175     


Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu 
            180                 185                 190         


Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu 
        195                 200                 205             


Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys 
    210                 215                 220                 


Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile 
225                 230                 235                 240 


His Ser Val Lys Lys Leu Ala Asp Val Thr Ile Leu Thr Ile Phe Cys 
                245                 250                 255     


Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu 
            260                 265                 270         


Lys Asn Lys Cys Val Lys Asn Asp Met Ala Val Asn Glu Thr Thr Asn 
        275                 280                 285             


Tyr Ser Ser His Arg Lys Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr 
    290                 295                 300                 


Ser Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ser Gly His Cys Pro 
305                 310                 315                 320 


Asp Gly Tyr Ile Cys Leu Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr 
                325                 330                 335     


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu 
            340                 345                 350         


Met Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr 
        355                 360                 365             


Ser Gly Lys Ile Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly 
    370                 375                 380                 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr 
385                 390                 395                 400 


Glu Glu Gln Asn Gln Ala Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys 
                405                 410                 415     


Lys Phe Gln Glu Ala Leu Glu Met Leu Arg Lys Glu Gln Glu Val Leu 
            420                 425                 430         


Ala Ala Leu Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser 
        435                 440                 445             


Pro Leu Thr Ser Lys Asn Ala Ser Glu Arg Arg His Arg Ile Lys Pro 
    450                 455                 460                 


Arg Val Ser Glu Gly Ser Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp 
465                 470                 475                 480 


Pro Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ala Ser Gly Lys 
                485                 490                 495     


Arg Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ser Pro Gly Arg 
            500                 505                 510         


Asp Ile Ser Leu Pro Glu Gly Val Thr Asp Asp Gly Val Phe Pro Gly 
        515                 520                 525             


Asp His Glu Ser His Arg Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly 
    530                 535                 540                 


Gln Gln Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro 
545                 550                 555                 560 


Asp Ser Arg His Gly Glu Asp Glu His Gln Pro Pro Pro Thr Ser Glu 
                565                 570                 575     


Leu Ala Pro Gly Ala Val Asp Val Ser Ala Phe Asp Ala Gly Gln Lys 
            580                 585                 590         


Lys Thr Phe Leu Ser Ala Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln 
        595                 600                 605             


Arg Ala Met Ser Val Val Ser Ile Ile Thr Ser Val Leu Glu Glu Leu 
    610                 615                 620                 


Glu Glu Ser Glu Gln Lys Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln 
625                 630                 635                 640 


Lys Tyr Leu Ile Trp Asp Cys Cys Pro Met Trp Val Lys Leu Lys Thr 
                645                 650                 655     


Ile Leu Phe Gly Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr 
            660                 665                 670         


Leu Cys Ile Val Val Asn Thr Ile Phe Met Ala Met Glu His His Gly 
        675                 680                 685             


Met Ser Pro Thr Phe Glu Ala Met Leu Gln Ile Gly Asn Ile Val Phe 
    690                 695                 700                 


Thr Ile Phe Phe Thr Ala Glu Met Val Phe Lys Ile Ile Ala Phe Asp 
705                 710                 715                 720 


Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile 
                725                 730                 735     


Val Thr Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu 
            740                 745                 750         


Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys 
        755                 760                 765             


Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val 
    770                 775                 780                 


Gly Ala Leu Gly Asn Leu Thr Ile Ile Leu Ala Ile Ile Val Phe Val 
785                 790                 795                 800 


Phe Ala Leu Val Gly Lys Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn 
                805                 810                 815     


Arg Lys Asn Ile Ser Ala Pro His Glu Asp Trp Pro Arg Trp His Met 
            820                 825                 830         


His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly 
        835                 840                 845             


Glu Trp Ile Glu Asn Met Trp Ala Cys Met Glu Val Gly Gln Lys Ser 
    850                 855                 860                 


Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val 
865                 870                 875                 880 


Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp 
                885                 890                 895     


Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Val 
            900                 905                 910         


Ala Leu Ala Arg Ile Gln Val Phe Gly His Arg Thr Lys Gln Ala Leu 
        915                 920                 925             


Cys Ser Phe Phe Ser Arg Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu 
    930                 935                 940                 


Pro Glu Leu Val Val Lys Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn 
945                 950                 955                 960 


His Ile Ala Ala Asn Thr Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala 
                965                 970                 975     


Pro Arg Gly Pro Arg Asp Glu His Ser Asp Phe Ile Ala Asn Pro Thr 
            980                 985                 990         


Val Trp Val Ser Val Pro Ile Ala  Glu Gly Glu Ser Asp  Leu Asp Asp 
        995                 1000                 1005             


Leu Glu  Asp Asp Gly Gly Glu  Asp Ala Gln Ser Phe  Gln Gln Glu 
    1010                 1015                 1020             


Val Ile  Pro Lys Gly Gln Gln  Glu Gln Leu Gln Gln  Val Glu Arg 
    1025                 1030                 1035             


Cys Gly  Asp His Leu Thr Pro  Arg Ser Pro Gly Thr  Gly Thr Ser 
    1040                 1045                 1050             


Ser Glu  Asp Leu Ala Pro Ser  Leu Gly Glu Thr Trp  Lys Asp Glu 
    1055                 1060                 1065             


Ser Val  Pro Gln Val Pro Ala  Glu Gly Val Asp Asp  Thr Ser Ser 
    1070                 1075                 1080             


Ser Glu  Gly Ser Thr Val Asp  Cys Leu Asp Pro Glu  Glu Ile Leu 
    1085                 1090                 1095             


Arg Lys  Ile Pro Glu Leu Ala  Asp Asp Leu Glu Glu  Pro Asp Asp 
    1100                 1105                 1110             


Cys Phe  Thr Glu Gly Cys Ile  Arg His Cys Pro Cys  Cys Lys Leu 
    1115                 1120                 1125             


Asp Thr  Thr Lys Ser Pro Trp  Asp Val Gly Trp Gln  Val Arg Lys 
    1130                 1135                 1140             


Thr Cys  Tyr Arg Ile Val Glu  His Ser Trp Phe Glu  Ser Phe Ile 
    1145                 1150                 1155             


Ile Phe  Met Ile Leu Leu Ser  Ser Gly Ser Leu Ala  Phe Glu Asp 
    1160                 1165                 1170             


Tyr Tyr  Leu Asp Gln Lys Pro  Thr Val Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Thr Asp  Arg Val Phe Thr Phe  Ile Phe Val Phe Glu  Met Leu Leu 
    1190                 1195                 1200             


Lys Trp  Val Ala Tyr Gly Phe  Lys Lys Tyr Phe Thr  Asn Ala Trp 
    1205                 1210                 1215             


Cys Trp  Leu Asp Phe Leu Ile  Val Asn Ile Ser Leu  Ile Ser Leu 
    1220                 1225                 1230             


Thr Ala  Lys Ile Leu Glu Tyr  Ser Glu Val Ala Pro  Ile Lys Ala 
    1235                 1240                 1245             


Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg 
    1250                 1255                 1260             


Phe Glu  Gly Met Arg Val Val  Val Asp Ala Leu Val  Gly Ala Ile 
    1265                 1270                 1275             


Pro Ser  Ile Met Asn Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu 
    1280                 1285                 1290             


Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe Ala Gly  Lys Phe Trp 
    1295                 1300                 1305             


Arg Cys  Ile Asn Tyr Thr Asp  Gly Glu Phe Ser Leu  Val Pro Leu 
    1310                 1315                 1320             


Ser Ile  Val Asn Asn Lys Ser  Asp Cys Lys Ile Gln  Asn Ser Thr 
    1325                 1330                 1335             


Gly Ser  Phe Phe Trp Val Asn  Val Lys Val Asn Phe  Asp Asn Val 
    1340                 1345                 1350             


Ala Met  Gly Tyr Leu Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly 
    1355                 1360                 1365             


Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp Ser Arg  Glu Val Asn 
    1370                 1375                 1380             


Met Gln  Pro Lys Trp Glu Asp  Asn Val Tyr Met Tyr  Leu Tyr Phe 
    1385                 1390                 1395             


Val Ile  Phe Ile Ile Phe Gly  Gly Phe Phe Thr Leu  Asn Leu Phe 
    1400                 1405                 1410             


Val Gly  Val Ile Ile Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu 
    1415                 1420                 1425             


Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr 
    1430                 1435                 1440             


Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile 
    1445                 1450                 1455             


Pro Arg  Pro Leu Asn Lys Phe  Gln Gly Phe Val Phe  Asp Ile Val 
    1460                 1465                 1470             


Thr Arg  Gln Ala Phe Asp Ile  Thr Ile Met Val Leu  Ile Cys Leu 
    1475                 1480                 1485             


Asn Met  Ile Thr Met Met Val  Glu Thr Asp Asp Gln  Ser Glu Glu 
    1490                 1495                 1500             


Lys Thr  Lys Ile Leu Gly Lys  Ile Asn Gln Phe Phe  Val Ala Val 
    1505                 1510                 1515             


Phe Thr  Gly Glu Cys Val Met  Lys Met Phe Ala Leu  Arg Gln Tyr 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Gly Trp Asn  Val Phe Asp Phe Ile  Val Val Val 
    1535                 1540                 1545             


Leu Ser  Ile Ala Ser Leu Ile  Phe Ser Ala Ile Leu  Lys Ser Leu 
    1550                 1555                 1560             


Gln Ser  Tyr Phe Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1565                 1570                 1575             


Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg Ala Ala  Lys Gly Ile 
    1580                 1585                 1590             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1595                 1600                 1605             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile 
    1610                 1615                 1620             


Phe Gly  Met Ser Ser Phe Pro  His Val Arg Trp Glu  Ala Gly Ile 
    1625                 1630                 1635             


Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala Asn Ser  Met Leu Cys 
    1640                 1645                 1650             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ser 
    1655                 1660                 1665             


Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys Asp Pro  Asn Leu Pro 
    1670                 1675                 1680             


Asn Ser  Asn Gly Thr Arg Gly  Asp Cys Gly Ser Pro  Ala Val Gly 
    1685                 1690                 1695             


Ile Ile  Phe Phe Thr Thr Tyr  Ile Ile Ile Ser Phe  Leu Ile Met 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Asn Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu Asp Asp  Phe Asp Met 
    1730                 1735                 1740             


Phe Tyr  Glu Thr Trp Glu Lys  Phe Asp Pro Glu Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Thr  Phe Ser Ala Leu Ser  Asp Phe Ala Asp Thr  Leu Ser Gly 
    1760                 1765                 1770             


Pro Leu  Arg Ile Pro Lys Pro  Asn Arg Asn Ile Leu  Ile Gln Met 
    1775                 1780                 1785             


Asp Leu  Pro Leu Val Pro Gly  Asp Lys Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Asn  Val Leu Gly Glu Ser  Gly Glu Leu 
    1805                 1810                 1815             


Asp Ser  Leu Lys Ala Asn Met  Glu Glu Lys Phe Met  Ala Thr Asn 
    1820                 1825                 1830             


Leu Ser  Lys Ser Ser Tyr Glu  Pro Ile Ala Thr Thr  Leu Arg Trp 
    1835                 1840                 1845             


Lys Gln  Glu Asp Ile Ser Ala  Thr Val Ile Gln Lys  Ala Tyr Arg 
    1850                 1855                 1860             


Ser Tyr  Val Leu His Arg Ser  Met Ala Leu Ser Asn  Thr Pro Cys 
    1865                 1870                 1875             


Val Pro  Arg Ala Glu Glu Glu  Ala Ala Ser Leu Pro  Asp Glu Gly 
    1880                 1885                 1890             


Phe Val  Ala Phe Thr Ala Asn  Glu Asn Cys Val Leu  Pro Asp Lys 
    1895                 1900                 1905             


Ser Glu  Thr Ala Ser Ala Thr  Ser Phe Pro Pro Ser  Tyr Glu Ser 
    1910                 1915                 1920             


Val Thr  Arg Gly Leu Ser Asp  Arg Val Asn Met Arg  Thr Ser Ser 
    1925                 1930                 1935             


Ser Ile  Gln Asn Glu Asp Glu  Ala Thr Ser Met Glu  Leu Ile Ala 
    1940                 1945                 1950             


Pro Gly  Pro 
    1955     


<210>  25
<211>  4463
<212>  DNA
<213>  Homo sapiens

<400>  25
gcagcgcgca ccgagccggc cgcgccgcgc ccgccgctct cgccgctttc gccgcggtct       60

cctcctctag cgcccgccgc ggccggtaaa tctcggctgg aggagcagcg gcggcccccg      120

agtcaacttt cattcccttt ttgcttctgc ctcaccattc tcttctcctc ctcgaaagat      180

ggctgtttgg agaaggggga gaagttaaga ggtcgccagc gcggagcgaa ggagggcgcg      240

atagcctcag caggagcggg cggaggtttc tcctctgcca acccctcctg gaccattgtc      300

agcagttgaa cgacaaaggc tgtgaatctg catcctagtc ttagcagtcc ctctgattct      360

catgatgagc tcacctgcac agcctgacct catgtggaac cttgtaccat gggtgctatt      420

ctgtggctgc tgtaggatct tcccagatgg ggtggctgga cgagagcagc tcttggctca      480

gcaaagaatg cacagtatga tcagctcagt ggatgtgaag tcagaagttc ctgtgggcct      540

ggagcccatc tcacctttag acctaaggac agacctcagg atgatgatgc ccgtggtgga      600

ccctgttgtc cgtgagaagc aattgcagca ggaattactt cttatccagc agcagcaaca      660

aatccagaag cagcttctga tagcagagtt tcagaaacag catgagaact tgacacggca      720

gcaccaggct cagcttcagg agcatatcaa ggaacttcta gccataaaac agcaacaaga      780

actcctagaa aaggagcaga aactggagca gcagaggcaa gaacaggaag tagagaggca      840

tcgcagagaa cagcagcttc ctcctctcag aggcaaagat agaggacgag aaagggcagt      900

ggcaagtaca gaagtaaagc agaagcttca agagttccta ctgagtaaat cagcaacgaa      960

agacactcca actaatggaa aaaatcattc cgtgagccgc catcccaagc tctggtacac     1020

ggctgcccac cacacatcat tggatcaaag ctctccaccc cttagtggaa catctccatc     1080

ctacaagtac acattaccag gagcacaaga tgcaaaggat gatttccccc ttcgaaaaac     1140

tgaatcctca gtcagtagca gttctccagg ctctggtccc agttcaccaa acaatgggcc     1200

aactggaagt gttactgaaa atgagacttc ggttttgccc cctacccctc atgccgagca     1260

aatggtttca cagcaacgca ttctaattca tgaagattcc atgaacctgc taagtcttta     1320

tacctctcct tctttgccca acattacctt ggggcttccc gcagtgccat cccagctcaa     1380

tgcttcgaat tcactcaaag aaaagcagaa gtgtgagacg cagacgctta ggcaaggtgt     1440

tcctctgcct gggcagtatg gaggcagcat cccggcatct tccagccacc ctcatgttac     1500

tttagaggga aagccaccca acagcagcca ccaggctctc ctgcagcatt tattattgaa     1560

agaacaaatg cgacagcaaa agcttcttgt agctggtgga gttcccttac atcctcagtc     1620

tcccttggca acaaaagaga gaatttcacc tggcattaga ggtacccaca aattgccccg     1680

tcacagaccc ctgaaccgaa cccagtctgc acctttgcct cagagcacgt tggctcagct     1740

ggtcattcaa cagcaacacc agcaattctt ggagaagcag aagcaatacc agcagcagat     1800

ccacatgaac aaactgcttt cgaaatctat tgaacaactg aagcaaccag gcagtcacct     1860

tgaggaagca gaggaagagc ttcaggggga ccaggcgatg caggaagaca gagcgccctc     1920

tagtggcaac agcactagga gcgacagcag tgcttgtgtg gatgacacac tgggacaagt     1980

tggggctgtg aaggtcaagg aggaaccagt ggacagtgat gaagatgctc agatccagga     2040

aatggaatct ggggagcagg ctgcttttat gcaacaggta ataggcaaag atttagctcc     2100

aggatttgta attaaagtca ttatctgaac atgaaatgca ttgcaggttt ggtaaatgga     2160

tatgatttcc tatcagttta tatttctcta tgatttgagt tcagtgttta aggattctac     2220

ctaatgcaga tatatgtata tatctatata gaggtctttc tatatactga tctctatata     2280

gatatcaatg tttcattgaa aatccactgg taaggaaata cctgttatac taaaattatg     2340

atacataata tctgagcagt taataggctt taaatttatc ccaaagcctg ctacaccaat     2400

tacttctaaa gaaaacaaat tcactgttat tttgagttta tgtgttgaga tcagtgactg     2460

ctggatagtc tcccagtctg atcaatgaag cattcgatta gtttttgatt ttttgcaaca     2520

tctagaattt aattttcaca tcactgtaca taatgtatca tactatagtc ttgaacactg     2580

ttaaaggtag tctgcccctt ccttcctctc tcttttttta gttaagtaga aatgttctgg     2640

tcaccatgcc agtagtccta ggttattgtg taggttgcaa ttgaacatat taggaataca     2700

ggtggtttta aatatataga tgcaaattgc agcactactt taaatattag attatgtctc     2760

acatagcact gctcatttta cttttatttt gtgtaatttg atgacactgt ctatcaaaaa     2820

agagcaaatg aagcagatgc aaatgttagt gagaagtaat gtgcagcatt atggtccaat     2880

cagatacaat attgtgtcta caattgcaaa aaacacagta acaggatgaa tattatctga     2940

tatcaagtca aaatcagttt gaaaagaagg tgtatcatat tttatattgt cactagaatc     3000

tcttaagtat aattccataa tgacatgggc atataccgta acattctggc aaataacaat     3060

tagaaaagat aggtttaaca aaaaaattta cttgtatata atgcaccttc aggaggacta     3120

tgtcctttga tgctataaaa tacaaacaac tttgaaggca acagaagaca ctgtttattc     3180

aagtcagttc tttgtcaggt tcctgctgtt ctcctacaga aaagtgattc tgtgagggtg     3240

aacaggaaat gccttgtgga aacaggaagt ccaagtgatt catgtactga ggaatgtagg     3300

aaaaaaaatc tgaggatagt gctttactct ttctgttttt aaagggcact ctatgaattg     3360

atttattgtc taagaaaata acaccacaag tagggaaatt gttacggaag cttttcactg     3420

gaacatttcc ttcatattcc cttttgatat gtttaccttg ttttataggt ttacttttgt     3480

taagctagtt aaaggttcgt tgtattaaga cccctttaat atggataatc caaattgacc     3540

tagaatcttt gtgaggtttt ttctattaaa atatttatat ttctaaatcc gaggtatttc     3600

aaggtgtagt atcctatttc aaaggagata tagcagtttt gccaaatgta gacattgttc     3660

aactgtatgt tattggcacg tgttgtttac attttgctgt gacatttaaa aatatttctt     3720

taaaaatgtt actgctaaag atacattatc cttttttaaa aagtctccat tcaaattaaa     3780

ttaacataac tagaagttag aaagtttaaa agttttccac ataatgaaag tccttctgat     3840

aatttgacaa atagctataa taggaacact ccctatcacc aacatatttt ggttagtata     3900

ttccttcata ttaaaatgac tttttgtcag ttgttttgca ttaaaaatat ggcatgccta     3960

agataaaatt gtatattttt tccatctcat aaatattcat tttcttcaaa gtcttttttc     4020

aatctcataa aaaagggata gtgcatcttt taaaatacat tttatttggg gaggaacatg     4080

tggctgagca gacttttgta taatattact tcaaagatat gtaatcacaa acaaaaaaaa     4140

ctatttttta taatgtcatt tgagagagtt tcatcagtac agttggtgga cgttaattgt     4200

ttgaatttga tagtctttga atttaatcaa gaaactacct ggaaccagtg aaaaggaaag     4260

ctggacttaa ataatcttag aattaattga taaatgtctc ttttaaaatc tactgtattt     4320

attataattt acacccttga aggtgatctc ttgttttgtg ttgtaaatat attgtttgta     4380

tgtttccctt cttgccttct gttataagtc tcttcctttc tcaaataaag ttttttttaa     4440

aagaaaaaaa aaaaaaaaaa aaa                                             4463


<210>  26
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Met Ser Ser Pro Ala Gln Pro Asp Leu Met Trp Asn Leu Val Pro 
1               5                   10                  15      


Trp Val Leu Phe Cys Gly Cys Cys Arg Ile Phe Pro Asp Gly Val Ala 
            20                  25                  30          


Gly Arg Glu Gln Leu Leu Ala Gln Gln Arg Met His Ser Met Ile Ser 
        35                  40                  45              


Ser Val Asp Val Lys Ser Glu Val Pro Val Gly Leu Glu Pro Ile Ser 
    50                  55                  60                  


Pro Leu Asp Leu Arg Thr Asp Leu Arg Met Met Met Pro Val Val Asp 
65                  70                  75                  80  


Pro Val Val Arg Glu Lys Gln Leu Gln Gln Glu Leu Leu Leu Ile Gln 
                85                  90                  95      


Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu Ile Ala Glu Phe Gln Lys 
            100                 105                 110         


Gln His Glu Asn Leu Thr Arg Gln His Gln Ala Gln Leu Gln Glu His 
        115                 120                 125             


Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln Gln Glu Leu Leu Glu Lys 
    130                 135                 140                 


Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu Gln Glu Val Glu Arg His 
145                 150                 155                 160 


Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg Gly Lys Asp Arg Gly Arg 
                165                 170                 175     


Glu Arg Ala Val Ala Ser Thr Glu Val Lys Gln Lys Leu Gln Glu Phe 
            180                 185                 190         


Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr Pro Thr Asn Gly Lys Asn 
        195                 200                 205             


His Ser Val Ser Arg His Pro Lys Leu Trp Tyr Thr Ala Ala His His 
    210                 215                 220                 


Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu Ser Gly Thr Ser Pro Ser 
225                 230                 235                 240 


Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp Ala Lys Asp Asp Phe Pro 
                245                 250                 255     


Leu Arg Lys Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly Ser Gly 
            260                 265                 270         


Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu Asn Glu 
        275                 280                 285             


Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val Ser Gln 
    290                 295                 300                 


Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser Leu Tyr 
305                 310                 315                 320 


Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala Val Pro 
                325                 330                 335     


Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys Cys Glu 
            340                 345                 350         


Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr Gly Gly 
        355                 360                 365             


Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu Gly Lys 
    370                 375                 380                 


Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu Leu Lys 
385                 390                 395                 400 


Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val Pro Leu 
                405                 410                 415     


His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro Gly Ile 
            420                 425                 430         


Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg Thr Gln 
        435                 440                 445             


Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile Gln Gln 
    450                 455                 460                 


Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln Gln Ile 
465                 470                 475                 480 


His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys Gln Pro 
                485                 490                 495     


Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp Gln Ala 
            500                 505                 510         


Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg Ser Asp 
        515                 520                 525             


Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala Val Lys 
    530                 535                 540                 


Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile Gln Glu 
545                 550                 555                 560 


Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Val Ile Gly Lys 
                565                 570                 575     


Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile Ile 
            580                 585             


<210>  27
<211>  4126
<212>  DNA
<213>  Homo sapiens

<400>  27
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac       60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct      120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg      180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc      240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta      300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa      360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt      420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg      480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa      540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc      600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc      660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca      720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag      780

gatgatttcc cccttcgaaa aactgaatcc tcagtcagta gcagttctcc aggctctggt      840

cccagttcac caaacaatgg gccaactgga agtgttactg aaaatgagac ttcggttttg      900

ccccctaccc ctcatgccga gcaaatggtt tcacagcaac gcattctaat tcatgaagat      960

tccatgaacc tgctaagtct ttatacctct ccttctttgc ccaacattac cttggggctt     1020

cccgcagtgc catcccagct caatgcttcg aattcactca aagaaaagca gaagtgtgag     1080

acgcagacgc ttaggcaagg tgttcctctg cctgggcagt atggaggcag catcccggca     1140

tcttccagcc accctcatgt tactttagag ggaaagccac ccaacagcag ccaccaggct     1200

ctcctgcagc atttattatt gaaagaacaa atgcgacagc aaaagcttct tgtagctggt     1260

ggagttccct tacatcctca gtctcccttg gcaacaaaag agagaatttc acctggcatt     1320

agaggtaccc acaaattgcc ccgtcacaga cccctgaacc gaacccagtc tgcacctttg     1380

cctcagagca cgttggctca gctggtcatt caacagcaac accagcaatt cttggagaag     1440

cagaagcaat accagcagca gatccacatg aacaaactgc tttcgaaatc tattgaacaa     1500

ctgaagcaac caggcagtca ccttgaggaa gcagaggaag agcttcaggg ggaccaggcg     1560

atgcaggaag acagagcgcc ctctagtggc aacagcacta ggagcgacag cagtgcttgt     1620

gtggatgaca cactgggaca agttggggct gtgaaggtca aggaggaacc agtggacagt     1680

gatgaagatg ctcagatcca ggaaatggaa tctggggagc aggctgcttt tatgcaacag     1740

gtaataggca aagatttagc tccaggattt gtaattaaag tcattatctg aacatgaaat     1800

gcattgcagg tttggtaaat ggatatgatt tcctatcagt ttatatttct ctatgatttg     1860

agttcagtgt ttaaggattc tacctaatgc agatatatgt atatatctat atagaggtct     1920

ttctatatac tgatctctat atagatatca atgtttcatt gaaaatccac tggtaaggaa     1980

atacctgtta tactaaaatt atgatacata atatctgagc agttaatagg ctttaaattt     2040

atcccaaagc ctgctacacc aattacttct aaagaaaaca aattcactgt tattttgagt     2100

ttatgtgttg agatcagtga ctgctggata gtctcccagt ctgatcaatg aagcattcga     2160

ttagtttttg attttttgca acatctagaa tttaattttc acatcactgt acataatgta     2220

tcatactata gtcttgaaca ctgttaaagg tagtctgccc cttccttcct ctctcttttt     2280

ttagttaagt agaaatgttc tggtcaccat gccagtagtc ctaggttatt gtgtaggttg     2340

caattgaaca tattaggaat acaggtggtt ttaaatatat agatgcaaat tgcagcacta     2400

ctttaaatat tagattatgt ctcacatagc actgctcatt ttacttttat tttgtgtaat     2460

ttgatgacac tgtctatcaa aaaagagcaa atgaagcaga tgcaaatgtt agtgagaagt     2520

aatgtgcagc attatggtcc aatcagatac aatattgtgt ctacaattgc aaaaaacaca     2580

gtaacaggat gaatattatc tgatatcaag tcaaaatcag tttgaaaaga aggtgtatca     2640

tattttatat tgtcactaga atctcttaag tataattcca taatgacatg ggcatatacc     2700

gtaacattct ggcaaataac aattagaaaa gataggttta acaaaaaaat ttacttgtat     2760

ataatgcacc ttcaggagga ctatgtcctt tgatgctata aaatacaaac aactttgaag     2820

gcaacagaag acactgttta ttcaagtcag ttctttgtca ggttcctgct gttctcctac     2880

agaaaagtga ttctgtgagg gtgaacagga aatgccttgt ggaaacagga agtccaagtg     2940

attcatgtac tgaggaatgt aggaaaaaaa atctgaggat agtgctttac tctttctgtt     3000

tttaaagggc actctatgaa ttgatttatt gtctaagaaa ataacaccac aagtagggaa     3060

attgttacgg aagcttttca ctggaacatt tccttcatat tcccttttga tatgtttacc     3120

ttgttttata ggtttacttt tgttaagcta gttaaaggtt cgttgtatta agaccccttt     3180

aatatggata atccaaattg acctagaatc tttgtgaggt tttttctatt aaaatattta     3240

tatttctaaa tccgaggtat ttcaaggtgt agtatcctat ttcaaaggag atatagcagt     3300

tttgccaaat gtagacattg ttcaactgta tgttattggc acgtgttgtt tacattttgc     3360

tgtgacattt aaaaatattt ctttaaaaat gttactgcta aagatacatt atcctttttt     3420

aaaaagtctc cattcaaatt aaattaacat aactagaagt tagaaagttt aaaagttttc     3480

cacataatga aagtccttct gataatttga caaatagcta taataggaac actccctatc     3540

accaacatat tttggttagt atattccttc atattaaaat gactttttgt cagttgtttt     3600

gcattaaaaa tatggcatgc ctaagataaa attgtatatt ttttccatct cataaatatt     3660

cattttcttc aaagtctttt ttcaatctca taaaaaaggg atagtgcatc ttttaaaata     3720

cattttattt ggggaggaac atgtggctga gcagactttt gtataatatt acttcaaaga     3780

tatgtaatca caaacaaaaa aaactatttt ttataatgtc atttgagaga gtttcatcag     3840

tacagttggt ggacgttaat tgtttgaatt tgatagtctt tgaatttaat caagaaacta     3900

cctggaacca gtgaaaagga aagctggact taaataatct tagaattaat tgataaatgt     3960

ctcttttaaa atctactgta tttattataa tttacaccct tgaaggtgat ctcttgtttt     4020

gtgttgtaaa tatattgttt gtatgtttcc cttcttgcct tctgttataa gtctcttcct     4080

ttctcaaata aagttttttt taaaagaaaa aaaaaaaaaa aaaaaa                    4126


<210>  28
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  28

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Glu Ser Ser Val Ser Ser 
    210                 215                 220                 


Ser Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly 
225                 230                 235                 240 


Ser Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala 
                245                 250                 255     


Glu Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met 
            260                 265                 270         


Asn Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu 
        275                 280                 285             


Gly Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys 
    290                 295                 300                 


Glu Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu 
305                 310                 315                 320 


Pro Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His 
                325                 330                 335     


Val Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu 
            340                 345                 350         


Gln His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val 
        355                 360                 365             


Ala Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu 
    370                 375                 380                 


Arg Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg 
385                 390                 395                 400 


Pro Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala 
                405                 410                 415     


Gln Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys 
            420                 425                 430         


Gln Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile 
        435                 440                 445             


Glu Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu 
    450                 455                 460                 


Leu Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly 
465                 470                 475                 480 


Asn Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly 
                485                 490                 495     


Gln Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu 
            500                 505                 510         


Asp Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met 
        515                 520                 525             


Gln Gln Val Ile Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val 
    530                 535                 540                 


Ile Ile 
545     


<210>  29
<211>  4304
<212>  DNA
<213>  Homo sapiens

<400>  29
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac       60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccagg tttaattggt      120

ttctttttct cgtgggtaga cttaataatt ttctacgtat tctgacaaag aaataacccc      180

gaagcacgtt cctatttccc acctgcttgt agtttccggg ataacctaaa ctccagagag      240

ctatagcatc cactctgtcc tttctgcttt gcacacagat ggggtggctg gacgagagca      300

gctcttggct cagcaaagaa tgcacagtat gatcagctca gtggatgtga agtcagaagt      360

tcctgtgggc ctggagccca tctcaccttt agacctaagg acagacctca ggatgatgat      420

gcccgtggtg gaccctgttg tccgtgagaa gcaattgcag caggaattac ttcttatcca      480

gcagcagcaa caaatccaga agcagcttct gatagcagag tttcagaaac agcatgagaa      540

cttgacacgg cagcaccagg ctcagcttca ggagcatatc aagttgcaac aggaacttct      600

agccataaaa cagcaacaag aactcctaga aaaggagcag aaactggagc agcagaggca      660

agaacaggaa gtagagaggc atcgcagaga acagcagctt cctcctctca gaggcaaaga      720

tagaggacga gaaagggcag tggcaagtac agaagtaaag cagaagcttc aagagttcct      780

actgagtaaa tcagcaacga aagacactcc aactaatgga aaaaatcatt ccgtgagccg      840

ccatcccaag ctctggtaca cggctgccca ccacacatca ttggatcaaa gctctccacc      900

ccttagtgga acatctccat cctacaagta cacattacca ggagcacaag atgcaaagga      960

tgatttcccc cttcgaaaaa ctgaatcctc agtcagtagc agttctccag gctctggtcc     1020

cagttcacca aacaatgggc caactggaag tgttactgaa aatgagactt cggttttgcc     1080

ccctacccct catgccgagc aaatggtttc acagcaacgc attctaattc atgaagattc     1140

catgaacctg ctaagtcttt atacctctcc ttctttgccc aacattacct tggggcttcc     1200

cgcagtgcca tcccagctca atgcttcgaa ttcactcaaa gaaaagcaga agtgtgagac     1260

gcagacgctt aggcaaggtg ttcctctgcc tgggcagtat ggaggcagca tcccggcatc     1320

ttccagccac cctcatgtta ctttagaggg aaagccaccc aacagcagcc accaggctct     1380

cctgcagcat ttattattga aagaacaaat gcgacagcaa aagcttcttg tagctggtgg     1440

agttccctta catcctcagt ctcccttggc aacaaaagag agaatttcac ctggcattag     1500

aggtacccac aaattgcccc gtcacagacc cctgaaccga acccagtctg cacctttgcc     1560

tcagagcacg ttggctcagc tggtcattca acagcaacac cagcaattct tggagaagca     1620

gaagcaatac cagcagcaga tccacatgaa caaactgctt tcgaaatcta ttgaacaact     1680

gaagcaacca ggcagtcacc ttgaggaagc agaggaagag cttcaggggg accaggcgat     1740

gcaggaagac agagcgccct ctagtggcaa cagcactagg agcgacagca gtgcttgtgt     1800

ggatgacaca ctgggacaag ttggggctgt gaaggtcaag gaggaaccag tggacagtga     1860

tgaagatgct cagatccagg aaatggaatc tggggagcag gctgctttta tgcaacaggt     1920

aataggcaaa gatttagctc caggatttgt aattaaagtc attatctgaa catgaaatgc     1980

attgcaggtt tggtaaatgg atatgatttc ctatcagttt atatttctct atgatttgag     2040

ttcagtgttt aaggattcta cctaatgcag atatatgtat atatctatat agaggtcttt     2100

ctatatactg atctctatat agatatcaat gtttcattga aaatccactg gtaaggaaat     2160

acctgttata ctaaaattat gatacataat atctgagcag ttaataggct ttaaatttat     2220

cccaaagcct gctacaccaa ttacttctaa agaaaacaaa ttcactgtta ttttgagttt     2280

atgtgttgag atcagtgact gctggatagt ctcccagtct gatcaatgaa gcattcgatt     2340

agtttttgat tttttgcaac atctagaatt taattttcac atcactgtac ataatgtatc     2400

atactatagt cttgaacact gttaaaggta gtctgcccct tccttcctct ctcttttttt     2460

agttaagtag aaatgttctg gtcaccatgc cagtagtcct aggttattgt gtaggttgca     2520

attgaacata ttaggaatac aggtggtttt aaatatatag atgcaaattg cagcactact     2580

ttaaatatta gattatgtct cacatagcac tgctcatttt acttttattt tgtgtaattt     2640

gatgacactg tctatcaaaa aagagcaaat gaagcagatg caaatgttag tgagaagtaa     2700

tgtgcagcat tatggtccaa tcagatacaa tattgtgtct acaattgcaa aaaacacagt     2760

aacaggatga atattatctg atatcaagtc aaaatcagtt tgaaaagaag gtgtatcata     2820

ttttatattg tcactagaat ctcttaagta taattccata atgacatggg catataccgt     2880

aacattctgg caaataacaa ttagaaaaga taggtttaac aaaaaaattt acttgtatat     2940

aatgcacctt caggaggact atgtcctttg atgctataaa atacaaacaa ctttgaaggc     3000

aacagaagac actgtttatt caagtcagtt ctttgtcagg ttcctgctgt tctcctacag     3060

aaaagtgatt ctgtgagggt gaacaggaaa tgccttgtgg aaacaggaag tccaagtgat     3120

tcatgtactg aggaatgtag gaaaaaaaat ctgaggatag tgctttactc tttctgtttt     3180

taaagggcac tctatgaatt gatttattgt ctaagaaaat aacaccacaa gtagggaaat     3240

tgttacggaa gcttttcact ggaacatttc cttcatattc ccttttgata tgtttacctt     3300

gttttatagg tttacttttg ttaagctagt taaaggttcg ttgtattaag acccctttaa     3360

tatggataat ccaaattgac ctagaatctt tgtgaggttt tttctattaa aatatttata     3420

tttctaaatc cgaggtattt caaggtgtag tatcctattt caaaggagat atagcagttt     3480

tgccaaatgt agacattgtt caactgtatg ttattggcac gtgttgttta cattttgctg     3540

tgacatttaa aaatatttct ttaaaaatgt tactgctaaa gatacattat ccttttttaa     3600

aaagtctcca ttcaaattaa attaacataa ctagaagtta gaaagtttaa aagttttcca     3660

cataatgaaa gtccttctga taatttgaca aatagctata ataggaacac tccctatcac     3720

caacatattt tggttagtat attccttcat attaaaatga ctttttgtca gttgttttgc     3780

attaaaaata tggcatgcct aagataaaat tgtatatttt ttccatctca taaatattca     3840

ttttcttcaa agtctttttt caatctcata aaaaagggat agtgcatctt ttaaaataca     3900

ttttatttgg ggaggaacat gtggctgagc agacttttgt ataatattac ttcaaagata     3960

tgtaatcaca aacaaaaaaa actatttttt ataatgtcat ttgagagagt ttcatcagta     4020

cagttggtgg acgttaattg tttgaatttg atagtctttg aatttaatca agaaactacc     4080

tggaaccagt gaaaaggaaa gctggactta aataatctta gaattaattg ataaatgtct     4140

cttttaaaat ctactgtatt tattataatt tacacccttg aaggtgatct cttgttttgt     4200

gttgtaaata tattgtttgt atgtttccct tcttgccttc tgttataagt ctcttccttt     4260

ctcaaataaa gtttttttta aaagaaaaaa aaaaaaaaaa aaaa                      4304


<210>  30
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  30

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala Ile 
                85                  90                  95      


Lys Gln Gln Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln 
            100                 105                 110         


Arg Gln Glu Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro 
        115                 120                 125             


Pro Leu Arg Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr 
    130                 135                 140                 


Glu Val Lys Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr 
145                 150                 155                 160 


Lys Asp Thr Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro 
                165                 170                 175     


Lys Leu Trp Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser 
            180                 185                 190         


Pro Pro Leu Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly 
        195                 200                 205             


Ala Gln Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Glu Ser Ser 
    210                 215                 220                 


Val Ser Ser Ser Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly 
225                 230                 235                 240 


Pro Thr Gly Ser Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr 
                245                 250                 255     


Pro His Ala Glu Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu 
            260                 265                 270         


Asp Ser Met Asn Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn 
        275                 280                 285             


Ile Thr Leu Gly Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn 
    290                 295                 300                 


Ser Leu Lys Glu Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly 
305                 310                 315                 320 


Val Pro Leu Pro Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser 
                325                 330                 335     


His Pro His Val Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln 
            340                 345                 350         


Ala Leu Leu Gln His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys 
        355                 360                 365             


Leu Leu Val Ala Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala 
    370                 375                 380                 


Thr Lys Glu Arg Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro 
385                 390                 395                 400 


Arg His Arg Pro Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser 
                405                 410                 415     


Thr Leu Ala Gln Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu 
            420                 425                 430         


Lys Gln Lys Gln Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser 
        435                 440                 445             


Lys Ser Ile Glu Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala 
    450                 455                 460                 


Glu Glu Glu Leu Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro 
465                 470                 475                 480 


Ser Ser Gly Asn Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp 
                485                 490                 495     


Thr Leu Gly Gln Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp 
            500                 505                 510         


Ser Asp Glu Asp Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala 
        515                 520                 525             


Ala Phe Met Gln Gln Val Ile Gly Lys Asp Leu Ala Pro Gly Phe Val 
    530                 535                 540                 


Ile Lys Val Ile Ile 
545                 


<210>  31
<211>  4118
<212>  DNA
<213>  Homo sapiens

<400>  31
acttaacttc tgccttgtgg aaggggtggg gaagccttta tcaatgggta ggtgggagaa       60

ccaggggaag actgtcagct acgattttct ctagcctcaa gaagactgag accgagccaa      120

actcctggcc aacgtgcttt gtggattcac agtgtagctt gagaaaaatg tggatgtgaa      180

gtcagaagtt cctgtgggcc tggagcccat ctcaccttta gacctaagga cagacctcag      240

gatgatgatg cccgtggtgg accctgttgt ccgtgagaag caattgcagc aggaattact      300

tcttatccag cagcagcaac aaatccagaa gcagcttctg atagcagagt ttcagaaaca      360

gcatgagaac ttgacacggc agcaccaggc tcagcttcag gagcatatca aggaacttct      420

agccataaaa cagcaacaag aactcctaga aaaggagcag aaactggagc agcagaggca      480

agaacaggaa gtagagaggc atcgcagaga acagcagctt cctcctctca gaggcaaaga      540

tagaggacga gaaagggcag tggcaagtac agaagtaaag cagaagcttc aagagttcct      600

actgagtaaa tcagcaacga aagacactcc aactaatgga aaaaatcatt ccgtgagccg      660

ccatcccaag ctctgggctg cccaccacac atcattggat caaagctctc caccccttag      720

tggaacatct ccatcctaca agtacacatt accaggagca caagatgcaa aggatgattt      780

cccccttcga aaaactgaat cctcagtcag tagcagttct ccaggctctg gtcccagttc      840

accaaacaat gggccaactg gaagtgttac tgaaaatgag acttcggttt tgccccctac      900

ccctcatgcc gagcaaatgg tttcacagca acgcattcta attcatgaag attccatgaa      960

cctgctaagt ctttatacct ctccttcttt gcccaacatt accttggggc ttcccgcagt     1020

gccatcccag ctcaatgctt cgaattcact caaagaaaag cagaagtgtg agacgcagac     1080

gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc agcatcccgg catcttccag     1140

ccaccctcat gttactttag agggaaagcc acccaacagc agccaccagg ctctcctgca     1200

gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt cttgtagctg gtggagttcc     1260

cttacatcct cagtctccct tggcaacaaa agagagaatt tcacctggca ttagaggtac     1320

ccacaaattg ccccgtcaca gacccctgaa ccgaacccag tctgcacctt tgcctcagag     1380

cacgttggct cagctggtca ttcaacagca acaccagcaa ttcttggaga agcagaagca     1440

ataccagcag cagatccaca tgaacaaact gctttcgaaa tctattgaac aactgaagca     1500

accaggcagt caccttgagg aagcagagga agagcttcag ggggaccagg cgatgcagga     1560

agacagagcg ccctctagtg gcaacagcac taggagcgac agcagtgctt gtgtggatga     1620

cacactggga caagttgggg ctgtgaaggt caaggaggaa ccagtggaca gtgatgaaga     1680

tgctcagatc caggaaatgg aatctgggga gcaggctgct tttatgcaac aggtaatagg     1740

caaagattta gctccaggat ttgtaattaa agtcattatc tgaacatgaa atgcattgca     1800

ggtttggtaa atggatatga tttcctatca gtttatattt ctctatgatt tgagttcagt     1860

gtttaaggat tctacctaat gcagatatat gtatatatct atatagaggt ctttctatat     1920

actgatctct atatagatat caatgtttca ttgaaaatcc actggtaagg aaatacctgt     1980

tatactaaaa ttatgataca taatatctga gcagttaata ggctttaaat ttatcccaaa     2040

gcctgctaca ccaattactt ctaaagaaaa caaattcact gttattttga gtttatgtgt     2100

tgagatcagt gactgctgga tagtctccca gtctgatcaa tgaagcattc gattagtttt     2160

tgattttttg caacatctag aatttaattt tcacatcact gtacataatg tatcatacta     2220

tagtcttgaa cactgttaaa ggtagtctgc cccttccttc ctctctcttt ttttagttaa     2280

gtagaaatgt tctggtcacc atgccagtag tcctaggtta ttgtgtaggt tgcaattgaa     2340

catattagga atacaggtgg ttttaaatat atagatgcaa attgcagcac tactttaaat     2400

attagattat gtctcacata gcactgctca ttttactttt attttgtgta atttgatgac     2460

actgtctatc aaaaaagagc aaatgaagca gatgcaaatg ttagtgagaa gtaatgtgca     2520

gcattatggt ccaatcagat acaatattgt gtctacaatt gcaaaaaaca cagtaacagg     2580

atgaatatta tctgatatca agtcaaaatc agtttgaaaa gaaggtgtat catattttat     2640

attgtcacta gaatctctta agtataattc cataatgaca tgggcatata ccgtaacatt     2700

ctggcaaata acaattagaa aagataggtt taacaaaaaa atttacttgt atataatgca     2760

ccttcaggag gactatgtcc tttgatgcta taaaatacaa acaactttga aggcaacaga     2820

agacactgtt tattcaagtc agttctttgt caggttcctg ctgttctcct acagaaaagt     2880

gattctgtga gggtgaacag gaaatgcctt gtggaaacag gaagtccaag tgattcatgt     2940

actgaggaat gtaggaaaaa aaatctgagg atagtgcttt actctttctg tttttaaagg     3000

gcactctatg aattgattta ttgtctaaga aaataacacc acaagtaggg aaattgttac     3060

ggaagctttt cactggaaca tttccttcat attccctttt gatatgttta ccttgtttta     3120

taggtttact tttgttaagc tagttaaagg ttcgttgtat taagacccct ttaatatgga     3180

taatccaaat tgacctagaa tctttgtgag gttttttcta ttaaaatatt tatatttcta     3240

aatccgaggt atttcaaggt gtagtatcct atttcaaagg agatatagca gttttgccaa     3300

atgtagacat tgttcaactg tatgttattg gcacgtgttg tttacatttt gctgtgacat     3360

ttaaaaatat ttctttaaaa atgttactgc taaagataca ttatcctttt ttaaaaagtc     3420

tccattcaaa ttaaattaac ataactagaa gttagaaagt ttaaaagttt tccacataat     3480

gaaagtcctt ctgataattt gacaaatagc tataatagga acactcccta tcaccaacat     3540

attttggtta gtatattcct tcatattaaa atgacttttt gtcagttgtt ttgcattaaa     3600

aatatggcat gcctaagata aaattgtata ttttttccat ctcataaata ttcattttct     3660

tcaaagtctt ttttcaatct cataaaaaag ggatagtgca tcttttaaaa tacattttat     3720

ttggggagga acatgtggct gagcagactt ttgtataata ttacttcaaa gatatgtaat     3780

cacaaacaaa aaaaactatt ttttataatg tcatttgaga gagtttcatc agtacagttg     3840

gtggacgtta attgtttgaa tttgatagtc tttgaattta atcaagaaac tacctggaac     3900

cagtgaaaag gaaagctgga cttaaataat cttagaatta attgataaat gtctctttta     3960

aaatctactg tatttattat aatttacacc cttgaaggtg atctcttgtt ttgtgttgta     4020

aatatattgt ttgtatgttt cccttcttgc cttctgttat aagtctcttc ctttctcaaa     4080

taaagttttt tttaaaagaa aaaaaaaaaa aaaaaaaa                             4118


<210>  32
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln 
1               5                   10                  15      


Gln Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu 
            20                  25                  30          


Leu Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His 
        35                  40                  45              


Gln Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln 
    50                  55                  60                  


Gln Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln 
65                  70                  75                  80  


Glu Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu 
                85                  90                  95      


Arg Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val 
            100                 105                 110         


Lys Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp 
        115                 120                 125             


Thr Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu 
    130                 135                 140                 


Trp Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu Ser 
145                 150                 155                 160 


Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp Ala 
                165                 170                 175     


Lys Asp Asp Phe Pro Leu Arg Lys Thr Glu Ser Ser Val Ser Ser Ser 
            180                 185                 190         


Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser 
        195                 200                 205             


Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu 
    210                 215                 220                 


Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn 
225                 230                 235                 240 


Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 
                245                 250                 255     


Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu 
            260                 265                 270         


Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro 
        275                 280                 285             


Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val 
    290                 295                 300                 


Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln 
305                 310                 315                 320 


His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala 
                325                 330                 335     


Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg 
            340                 345                 350         


Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro 
        355                 360                 365             


Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln 
    370                 375                 380                 


Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln 
385                 390                 395                 400 


Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu 
                405                 410                 415     


Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu 
            420                 425                 430         


Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn 
        435                 440                 445             


Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln 
    450                 455                 460                 


Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp 
465                 470                 475                 480 


Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln 
                485                 490                 495     


Gln Val Ile Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile 
            500                 505                 510         


Ile 
    


<210>  33
<211>  4265
<212>  DNA
<213>  Homo sapiens

<400>  33
acttaacttc tgccttgtgg aaggggtggg gaagccttta tcaatgggta ggtgggagaa       60

ccaggggaag actgtcagct acgattttct ctagcctcaa gaagactgag accgagccaa      120

actcctggcc aacgtgcttt gtggattcac agtgtagctt gagaaaaatg tggatgtgaa      180

gtcagaagtt cctgtgggcc tggagcccat ctcaccttta gacctaagga cagacctcag      240

gatgatgatg cccgtggtgg accctgttgt ccgtgagaag caattgcagc aggaattact      300

tcttatccag cagcagcaac aaatccagaa gcagcttctg atagcagagt ttcagaaaca      360

gcatgagaac ttgacacggc agcaccaggc tcagcttcag gagcatatca agttgcaaca      420

ggaacttcta gccataaaac agcaacaaga actcctagaa aaggagcaga aactggagca      480

gcagaggcaa gaacaggaag tagagaggca tcgcagagaa cagcagcttc ctcctctcag      540

aggcaaagat agaggacgag aaagggcagt ggcaagtaca gaagtaaagc agaagcttca      600

agagttccta ctgagtaaat cagcaacgaa agacactcca actaatggaa aaaatcattc      660

cgtgagccgc catcccaagc tctggtacac ggctgcccac cacacatcat tggatcaaag      720

ctctccaccc cttagtggaa catctccatc ctacaagtac acattaccag gagcacaaga      780

tgcaaaggat gatttccccc ttcgaaaaac tgcctctgag cccaacttga aggtgcggtc      840

caggttaaaa cagaaagtgg cagagaggag aagcagcccc ttactcaggc ggaaggatgg      900

aaatgttgtc acttcattca agaagcgaat gtttgaggtg acagaatcct cagtcagtag      960

cagttctcca ggctctggtc ccagttcacc aaacaatggg ccaactggaa gtgttactga     1020

aaatgagact tcggttttgc cccctacccc tcatgccgag caaatggttt cacagcaacg     1080

cattctaatt catgaagatt ccatgaacct gctaagtctt tatacctctc cttctttgcc     1140

caacattacc ttggggcttc ccgcagtgcc atcccagctc aatgcttcga attcactcaa     1200

agaaaagcag aagtgtgaga cgcagacgct taggcaaggt gttcctctgc ctgggcagta     1260

tggaggcagc atcccggcat cttccagcca ccctcatgtt actttagagg gaaagccacc     1320

caacagcagc caccaggctc tcctgcagca tttattattg aaagaacaaa tgcgacagca     1380

aaagcttctt gtagctggtg gagttccctt acatcctcag tctcccttgg caacaaaaga     1440

gagaatttca cctggcatta gaggtaccca caaattgccc cgtcacagac ccctgaaccg     1500

aacccagtct gcacctttgc ctcagagcac gttggctcag ctggtcattc aacagcaaca     1560

ccagcaattc ttggagaagc agaagcaata ccagcagcag atccacatga acaaactgct     1620

ttcgaaatct attgaacaac tgaagcaacc aggcagtcac cttgaggaag cagaggaaga     1680

gcttcagggg gaccaggcga tgcaggaaga cagagcgccc tctagtggca acagcactag     1740

gagcgacagc agtgcttgtg tggatgacac actgggacaa gttggggctg tgaaggtcaa     1800

ggaggaacca gtggacagtg atgaagatgc tcagatccag gaaatggaat ctggggagca     1860

ggctgctttt atgcaacagg taataggcaa agatttagct ccaggatttg taattaaagt     1920

cattatctga acatgaaatg cattgcaggt ttggtaaatg gatatgattt cctatcagtt     1980

tatatttctc tatgatttga gttcagtgtt taaggattct acctaatgca gatatatgta     2040

tatatctata tagaggtctt tctatatact gatctctata tagatatcaa tgtttcattg     2100

aaaatccact ggtaaggaaa tacctgttat actaaaatta tgatacataa tatctgagca     2160

gttaataggc tttaaattta tcccaaagcc tgctacacca attacttcta aagaaaacaa     2220

attcactgtt attttgagtt tatgtgttga gatcagtgac tgctggatag tctcccagtc     2280

tgatcaatga agcattcgat tagtttttga ttttttgcaa catctagaat ttaattttca     2340

catcactgta cataatgtat catactatag tcttgaacac tgttaaaggt agtctgcccc     2400

ttccttcctc tctctttttt tagttaagta gaaatgttct ggtcaccatg ccagtagtcc     2460

taggttattg tgtaggttgc aattgaacat attaggaata caggtggttt taaatatata     2520

gatgcaaatt gcagcactac tttaaatatt agattatgtc tcacatagca ctgctcattt     2580

tacttttatt ttgtgtaatt tgatgacact gtctatcaaa aaagagcaaa tgaagcagat     2640

gcaaatgtta gtgagaagta atgtgcagca ttatggtcca atcagataca atattgtgtc     2700

tacaattgca aaaaacacag taacaggatg aatattatct gatatcaagt caaaatcagt     2760

ttgaaaagaa ggtgtatcat attttatatt gtcactagaa tctcttaagt ataattccat     2820

aatgacatgg gcatataccg taacattctg gcaaataaca attagaaaag ataggtttaa     2880

caaaaaaatt tacttgtata taatgcacct tcaggaggac tatgtccttt gatgctataa     2940

aatacaaaca actttgaagg caacagaaga cactgtttat tcaagtcagt tctttgtcag     3000

gttcctgctg ttctcctaca gaaaagtgat tctgtgaggg tgaacaggaa atgccttgtg     3060

gaaacaggaa gtccaagtga ttcatgtact gaggaatgta ggaaaaaaaa tctgaggata     3120

gtgctttact ctttctgttt ttaaagggca ctctatgaat tgatttattg tctaagaaaa     3180

taacaccaca agtagggaaa ttgttacgga agcttttcac tggaacattt ccttcatatt     3240

cccttttgat atgtttacct tgttttatag gtttactttt gttaagctag ttaaaggttc     3300

gttgtattaa gaccccttta atatggataa tccaaattga cctagaatct ttgtgaggtt     3360

ttttctatta aaatatttat atttctaaat ccgaggtatt tcaaggtgta gtatcctatt     3420

tcaaaggaga tatagcagtt ttgccaaatg tagacattgt tcaactgtat gttattggca     3480

cgtgttgttt acattttgct gtgacattta aaaatatttc tttaaaaatg ttactgctaa     3540

agatacatta tcctttttta aaaagtctcc attcaaatta aattaacata actagaagtt     3600

agaaagttta aaagttttcc acataatgaa agtccttctg ataatttgac aaatagctat     3660

aataggaaca ctccctatca ccaacatatt ttggttagta tattccttca tattaaaatg     3720

actttttgtc agttgttttg cattaaaaat atggcatgcc taagataaaa ttgtatattt     3780

tttccatctc ataaatattc attttcttca aagtcttttt tcaatctcat aaaaaaggga     3840

tagtgcatct tttaaaatac attttatttg gggaggaaca tgtggctgag cagacttttg     3900

tataatatta cttcaaagat atgtaatcac aaacaaaaaa aactattttt tataatgtca     3960

tttgagagag tttcatcagt acagttggtg gacgttaatt gtttgaattt gatagtcttt     4020

gaatttaatc aagaaactac ctggaaccag tgaaaaggaa agctggactt aaataatctt     4080

agaattaatt gataaatgtc tcttttaaaa tctactgtat ttattataat ttacaccctt     4140

gaaggtgatc tcttgttttg tgttgtaaat atattgtttg tatgtttccc ttcttgcctt     4200

ctgttataag tctcttcctt tctcaaataa agtttttttt aaaagaaaaa aaaaaaaaaa     4260

aaaaa                                                                 4265


<210>  34
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln 
1               5                   10                  15      


Gln Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu 
            20                  25                  30          


Leu Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His 
        35                  40                  45              


Gln Ala Gln Leu Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala 
    50                  55                  60                  


Ile Lys Gln Gln Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln 
65                  70                  75                  80  


Gln Arg Gln Glu Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu 
                85                  90                  95      


Pro Pro Leu Arg Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser 
            100                 105                 110         


Thr Glu Val Lys Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala 
        115                 120                 125             


Thr Lys Asp Thr Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His 
    130                 135                 140                 


Pro Lys Leu Trp Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser 
145                 150                 155                 160 


Ser Pro Pro Leu Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro 
                165                 170                 175     


Gly Ala Gln Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser 
            180                 185                 190         


Glu Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu 
        195                 200                 205             


Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr 
    210                 215                 220                 


Ser Phe Lys Lys Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser 
225                 230                 235                 240 


Ser Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly 
                245                 250                 255     


Ser Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala 
            260                 265                 270         


Glu Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met 
        275                 280                 285             


Asn Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu 
    290                 295                 300                 


Gly Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys 
305                 310                 315                 320 


Glu Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu 
                325                 330                 335     


Pro Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His 
            340                 345                 350         


Val Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu 
        355                 360                 365             


Gln His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val 
    370                 375                 380                 


Ala Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu 
385                 390                 395                 400 


Arg Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg 
                405                 410                 415     


Pro Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala 
            420                 425                 430         


Gln Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys 
        435                 440                 445             


Gln Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile 
    450                 455                 460                 


Glu Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu 
465                 470                 475                 480 


Leu Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly 
                485                 490                 495     


Asn Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly 
            500                 505                 510         


Gln Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu 
        515                 520                 525             


Asp Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met 
    530                 535                 540                 


Gln Gln Val Ile Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val 
545                 550                 555                 560 


Ile Ile 
        


<210>  35
<211>  4238
<212>  DNA
<213>  Homo sapiens

<400>  35
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac       60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct      120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg      180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc      240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta      300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa      360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt      420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg      480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa      540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc      600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc      660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca      720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag      780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta      840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt      900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct      960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag     1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta     1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt     1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag     1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc     1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc     1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt     1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt     1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag     1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa     1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa     1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag     1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac     1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa     1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct     1860

tttatgcaac aggtaatagg caaagattta gctccaggat ttgtaattaa agtcattatc     1920

tgaacatgaa atgcattgca ggtttggtaa atggatatga tttcctatca gtttatattt     1980

ctctatgatt tgagttcagt gtttaaggat tctacctaat gcagatatat gtatatatct     2040

atatagaggt ctttctatat actgatctct atatagatat caatgtttca ttgaaaatcc     2100

actggtaagg aaatacctgt tatactaaaa ttatgataca taatatctga gcagttaata     2160

ggctttaaat ttatcccaaa gcctgctaca ccaattactt ctaaagaaaa caaattcact     2220

gttattttga gtttatgtgt tgagatcagt gactgctgga tagtctccca gtctgatcaa     2280

tgaagcattc gattagtttt tgattttttg caacatctag aatttaattt tcacatcact     2340

gtacataatg tatcatacta tagtcttgaa cactgttaaa ggtagtctgc cccttccttc     2400

ctctctcttt ttttagttaa gtagaaatgt tctggtcacc atgccagtag tcctaggtta     2460

ttgtgtaggt tgcaattgaa catattagga atacaggtgg ttttaaatat atagatgcaa     2520

attgcagcac tactttaaat attagattat gtctcacata gcactgctca ttttactttt     2580

attttgtgta atttgatgac actgtctatc aaaaaagagc aaatgaagca gatgcaaatg     2640

ttagtgagaa gtaatgtgca gcattatggt ccaatcagat acaatattgt gtctacaatt     2700

gcaaaaaaca cagtaacagg atgaatatta tctgatatca agtcaaaatc agtttgaaaa     2760

gaaggtgtat catattttat attgtcacta gaatctctta agtataattc cataatgaca     2820

tgggcatata ccgtaacatt ctggcaaata acaattagaa aagataggtt taacaaaaaa     2880

atttacttgt atataatgca ccttcaggag gactatgtcc tttgatgcta taaaatacaa     2940

acaactttga aggcaacaga agacactgtt tattcaagtc agttctttgt caggttcctg     3000

ctgttctcct acagaaaagt gattctgtga gggtgaacag gaaatgcctt gtggaaacag     3060

gaagtccaag tgattcatgt actgaggaat gtaggaaaaa aaatctgagg atagtgcttt     3120

actctttctg tttttaaagg gcactctatg aattgattta ttgtctaaga aaataacacc     3180

acaagtaggg aaattgttac ggaagctttt cactggaaca tttccttcat attccctttt     3240

gatatgttta ccttgtttta taggtttact tttgttaagc tagttaaagg ttcgttgtat     3300

taagacccct ttaatatgga taatccaaat tgacctagaa tctttgtgag gttttttcta     3360

ttaaaatatt tatatttcta aatccgaggt atttcaaggt gtagtatcct atttcaaagg     3420

agatatagca gttttgccaa atgtagacat tgttcaactg tatgttattg gcacgtgttg     3480

tttacatttt gctgtgacat ttaaaaatat ttctttaaaa atgttactgc taaagataca     3540

ttatcctttt ttaaaaagtc tccattcaaa ttaaattaac ataactagaa gttagaaagt     3600

ttaaaagttt tccacataat gaaagtcctt ctgataattt gacaaatagc tataatagga     3660

acactcccta tcaccaacat attttggtta gtatattcct tcatattaaa atgacttttt     3720

gtcagttgtt ttgcattaaa aatatggcat gcctaagata aaattgtata ttttttccat     3780

ctcataaata ttcattttct tcaaagtctt ttttcaatct cataaaaaag ggatagtgca     3840

tcttttaaaa tacattttat ttggggagga acatgtggct gagcagactt ttgtataata     3900

ttacttcaaa gatatgtaat cacaaacaaa aaaaactatt ttttataatg tcatttgaga     3960

gagtttcatc agtacagttg gtggacgtta attgtttgaa tttgatagtc tttgaattta     4020

atcaagaaac tacctggaac cagtgaaaag gaaagctgga cttaaataat cttagaatta     4080

attgataaat gtctctttta aaatctactg tatttattat aatttacacc cttgaaggtg     4140

atctcttgtt ttgtgttgta aatatattgt ttgtatgttt cccttcttgc cttctgttat     4200

aagtctcttc ctttctcaaa taaagttttt tttaaaag                             4238


<210>  36
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  36

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Val Ile 
                565                 570                 575     


Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile Ile 
            580                 585                 590 


<210>  37
<211>  3149
<212>  DNA
<213>  Homo sapiens

<400>  37
atggggtggc tggacgagag cagctcttgg ctcagcaaag aatgcacagt atgatcagct       60

cagtggatgt gaagtcagaa gttcctgtgg gcctggagcc catctcacct ttagacctaa      120

ggacagacct caggatgatg atgcccgtgg tggaccctgt tgtccgtgag aagcaattgc      180

agcaggaatt acttcttatc cagcagcagc aacaaatcca gaagcagctt ctgatagcag      240

agtttcagaa acagcatgag aacttgacac ggcagcacca ggctcagctt caggagcata      300

tcaaggaact tctagccata aaacagcaac aagaactcct agaaaaggag cagaaactgg      360

agcagcagag gcaagaacag gaagtagaga ggcatcgcag agaacagcag cttcctcctc      420

tcagaggcaa agatagagga cgagaaaggg cagtggcaag tacagaagta aagcagaagc      480

ttcaagagtt cctactgagt aaatcagcaa cgaaagacac tccaactaat ggaaaaaatc      540

attccgtgag ccgccatccc aagctctggt acacggctgc ccaccacaca tcattggatc      600

aaagctctcc accccttagt ggaacatctc catcctacaa gtacacatta ccaggagcac      660

aagatgcaaa ggatgatttc ccccttcgaa aaactgcctc tgagcccaac ttgaaggtgc      720

ggtccaggtt aaaacagaaa gtggcagaga ggagaagcag ccccttactc aggcggaagg      780

atggaaatgt tgtcacttca ttcaagaagc gaatgtttga ggtgacagaa tcctcagtca      840

gtagcagttc tccaggctct ggtcccagtt caccaaacaa tgggccaact ggaagtgtta      900

ctgaaaatga gacttcggtt ttgcccccta cccctcatgc cgagcaaatg gtttcacagc      960

aacgcattct aattcatgaa gattccatga acctgctaag tctttatacc tctccttctt     1020

tgcccaacat taccttgggg cttcccgcag tgccatccca gctcaatgct tcgaattcac     1080

tcaaagaaaa gcagaagtgt gagacgcaga cgcttaggca aggtgttcct ctgcctgggc     1140

agtatggagg cagcatcccg gcatcttcca gccaccctca tgttacttta gagggaaagc     1200

cacccaacag cagccaccag gctctcctgc agcatttatt attgaaagaa caaatgcgac     1260

agcaaaagct tcttgtagct ggtggagttc ccttacatcc tcagtctccc ttggcaacaa     1320

aagagagaat ttcacctggc attagaggta cccacaaatt gccccgtcac agacccctga     1380

accgaaccca gtctgcacct ttgcctcaga gcacgttggc tcagctggtc attcaacagc     1440

aacaccagca attcttggag aagcagaagc aataccagca gcagatccac atgaacaaac     1500

tgctttcgaa atctattgaa caactgaagc aaccaggcag tcaccttgag gaagcagagg     1560

aagagcttca gggggaccag gcgatgcagg aagacagagc gccctctagt ggcaacagca     1620

ctaggagcga cagcagtgct tgtgtggatg acacactggg acaagttggg gctgtgaagg     1680

tcaaggagga accagtggac agtgatgaag atgctcagat ccaggaaatg gaatctgggg     1740

agcaggctgc ttttatgcaa cagcctttcc tggaacccac gcacacacgt gcgctctctg     1800

tgcgccaagc tccgctggct gcggttggca tggatggatt agagaaacac cgtctcgtct     1860

ccaggactca ctcttcccct gctgcctctg ttttacctca cccagcaatg gaccgccccc     1920

tccagcctgg ctctgcaact ggaattgcct atgacccctt gatgctgaaa caccagtgcg     1980

tttgtggcaa ttccaccacc caccctgagc atgctggacg aatacagagt atctggtcac     2040

gactgcaaga aactgggctg ctaaataaat gtgagcgaat tcaaggtcga aaagccagcc     2100

tggaggaaat acagcttgtt cattctgaac atcactcact gttgtatggc accaaccccc     2160

tggacggaca gaagctggac cccaggatac tcctaggtga tgactctcaa aagttttttt     2220

cctcattacc ttgtggtgga cttggggtgg acagtgacac catttggaat gagctacact     2280

cgtccggtgc tgcacgcatg gctgttggct gtgtcatcga gctggcttcc aaagtggcct     2340

caggagagct gaagaatggg tttgctgttg tgaggccccc tggccatcac gctgaagaat     2400

ccacagccat ggggttctgc ttttttaatt cagttgcaat taccgccaaa tacttgagag     2460

accaactaaa tataagcaag atattgattg tagatctgga tgttcaccat ggaaacggta     2520

cccagcaggc cttttatgct gaccccagca tcctgtacat ttcactccat cgctatgatg     2580

aagggaactt tttccctggc agtggagccc caaatgaggt tggaacaggc cttggagaag     2640

ggtacaatat aaatattgcc tggacaggtg gccttgatcc tcccatggga gatgttgagt     2700

accttgaagc attcaggacc atcgtgaagc ctgtggccaa agagtttgat ccagacatgg     2760

tcttagtatc tgctggattt gatgcattgg aaggccacac ccctcctcta ggagggtaca     2820

aagtgacggc aaaatgtttt ggtcatttga cgaagcaatt gatgacattg gctgatggac     2880

gtgtggtgtt ggctctagaa ggaggacatg atctcacagc catctgtgat gcatcagaag     2940

cctgtgtaaa tgcccttcta ggaaatgagc tggagccact tgcagaagat attctccacc     3000

aaagcccgaa tatgaatgct gttatttctt tacagaagat cattgaaatt caaagtatgt     3060

ctttaaagtt ctcttaaaaa ttctaagcag gtaaaactaa ctaaaattat attgaaaatt     3120

atagtacaaa gaaacattta aaaaaaaaa                                       3149


<210>  38
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  38

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Pro Phe 
                565                 570                 575     


Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln Ala Pro Leu 
            580                 585                 590         


Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu Val Ser Arg 
        595                 600                 605             


Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro Ala Met Asp 
    610                 615                 620                 


Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr Asp Pro Leu 
625                 630                 635                 640 


Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr His Pro Glu 
                645                 650                 655     


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
            660                 665                 670         


Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala Ser Leu Glu 
        675                 680                 685             


Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu Tyr Gly Thr 
    690                 695                 700                 


Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu Leu Gly Asp 
705                 710                 715                 720 


Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly Leu Gly Val 
                725                 730                 735     


Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly Ala Ala Arg 
            740                 745                 750         


Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val Ala Ser Gly 
        755                 760                 765             


Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala 
    770                 775                 780                 


Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile 
785                 790                 795                 800 


Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys Ile Leu Ile 
                805                 810                 815     


Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr 
            820                 825                 830         


Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr Asp Glu Gly 
        835                 840                 845             


Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly Thr Gly Leu 
    850                 855                 860                 


Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly Leu Asp Pro 
865                 870                 875                 880 


Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr Ile Val Lys 
                885                 890                 895     


Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val Ser Ala Gly 
            900                 905                 910         


Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly Tyr Lys Val 
        915                 920                 925             


Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met Thr Leu Ala 
    930                 935                 940                 


Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala 
945                 950                 955                 960 


Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu Gly Asn Glu 
                965                 970                 975     


Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro Asn Met Asn 
            980                 985                 990         


Ala Val Ile Ser Leu Gln Lys Ile  Ile Glu Ile Gln Ser  Met Ser Leu 
        995                 1000                 1005             


Lys Phe  Ser 
    1010     


<210>  39
<211>  4659
<212>  DNA
<213>  Homo sapiens

<400>  39
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac       60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct      120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg      180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc      240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta      300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa      360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt      420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg      480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa      540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc      600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc      660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca      720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag      780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta      840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt      900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct      960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag     1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta     1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt     1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag     1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc     1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc     1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt     1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt     1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag     1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa     1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa     1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag     1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac     1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa     1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct     1860

tttatgcaac agcctttcct ggaacccacg cacacacgtg cgctctctgt gcgccaagct     1920

ccgctggctg cggttggcat ggatggatta gagaaacacc gtctcgtctc caggactcac     1980

tcttcccctg ctgcctctgt tttacctcac ccagcaatgg accgccccct ccagcctggc     2040

tctgcaactg gaattgccta tgaccccttg atgctgaaac accagtgcgt ttgtggcaat     2100

tccaccaccc accctgagca tgctggacga atacagagta tctggtcacg actgcaagaa     2160

actgggctgc taaataaatg tgagcgaatt caaggtcgaa aagccagcct ggaggaaata     2220

cagcttgttc attctgaaca tcactcactg ttgtatggca ccaaccccct ggacggacag     2280

aagctggacc ccaggatact cctaggtgat gactctcaaa agtttttttc ctcattacct     2340

tgtggtggac ttggggtgga cagtgacacc atttggaatg agctacactc gtccggtgct     2400

gcacgcatgg ctgttggctg tgtcatcgag ctggcttcca aagtggcctc aggagagctg     2460

aagaatgggt ttgctgttgt gaggccccct ggccatcacg ctgaagaatc cacagccatg     2520

gggttctgct tttttaattc agttgcaatt accgccaaat acttgagaga ccaactaaat     2580

ataagcaaga tattgattgt agatctggat gttcaccatg gaaacggtac ccagcaggcc     2640

ttttatgctg accccagcat cctgtacatt tcactccatc gctatgatga agggaacttt     2700

ttccctggca gtggagcccc aaatgaggtt ggaacaggcc ttggagaagg gtacaatata     2760

aatattgcct ggacaggtgg ccttgatcct cccatgggag atgttgagta ccttgaagca     2820

ttcaggacca tcgtgaagcc tgtggccaaa gagtttgatc cagacatggt cttagtatct     2880

gctggatttg atgcattgga aggccacacc cctcctctag gagggtacaa agtgacggca     2940

aaatgttttg gtcatttgac gaagcaattg atgacattgg ctgatggacg tgtggtgttg     3000

gctctagaag gaggacatga tctcacagcc atctgtgatg catcagaagc ctgtgtaaat     3060

gcccttctag gaaatgagct ggagccactt gcagaagata ttctccacca aagcccgaat     3120

atgaatgctg ttatttcttt acagaagatc attgaaattc aaagcaagta ttggaagtca     3180

gtaaggatgg tggctgtgcc aaggggctgt gctctggctg gtgctcagtt gcaagaggag     3240

acagagaccg tttctgccct ggcctcccta acagtggatg tggaacagcc ctttgctcag     3300

gaagacagca gaactgctgg tgagcctatg gaagaggagc cagccttgtg aagtgccaag     3360

tccccctctg atatttcctg tgtgtgacat cattgtgtat ccccccaccc cagtaccctc     3420

agacatgtct tgtctgctgc ctgggtggca cagattcaat ggaacataaa cactgggcac     3480

aaaattctga acagcagctt cacttgttct ttggatggac ttgaaagggc attaaagatt     3540

ccttaaacgt aaccgctgtg attctagagt tacagtaaac cacgattgga agaaactgct     3600

tccagcatgc ttttaatatg ctgggtgacc cactcctaga caccaagttt gaactagaaa     3660

cattcagtac agcactagat attgttaatt tcagaagcta tgacagccag tgaaattttg     3720

ggcaaaacct gagacatagt cattcctgac attctgatca gctttttttg gggtaatttg     3780

tttttcaaac agtcttaact tgtttacaag atttgctttt agctatgaac ggatcgtaat     3840

tccacccaga atgtaatgtt tcttgtttgt ttgttttgtt ttgttagggt ttttttctca     3900

actttaacac acagttcaac tgttcctagt aaaagttcaa gatggaggaa ctagcatgag     3960

gcttttttca gtatctcgaa gtccaaatgc caaaggaacc tcacacactg tttgtaatgg     4020

tgcaatattt tatatcactt ttttttaaac atccccaaca tctttgtgtt ctcacacaca     4080

ggcaatttgc aatgttgcaa ttgtgttgga gaatgaagtc cccccacctc ccagccacac     4140

acacatcctt tgttctcatg acagtaggtc tgagcaaatg ttccaccaag cattttcagt     4200

gtctttgaaa agcacgtaac ttttcaaagg tggtcttaat ttgttgcata tctatcaagg     4260

acttattcac tcacctttcc ttttctgccc tctatcaatt gatttcttct tacctttcat     4320

cattcattcc ttcctttaga aaaactgaag attacccata atctcctctt attacttgag     4380

ggccttgact atttagttta ttttgtttac tttacaggtt aacacagttg ttttgtctga     4440

ttgcatttta ttaactgtga agccgttgaa atgaatatca cttaagcaac gttgctaaat     4500

ttctatgtgt ttgaaatgtg ttaatgaagg cactgcttat ttgtagtcac cttgaactga     4560

cttaacctag aagctgtgcc ttcttgtgaa aaaaaaaaaa aacaaaaaca aaaaacagcc     4620

tttaaacaag tttccttagt gtcaaaagtt aaaaataaa                            4659


<210>  40
<211>  1066
<212>  PRT
<213>  Homo sapiens

<400>  40

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Pro Phe 
                565                 570                 575     


Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln Ala Pro Leu 
            580                 585                 590         


Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu Val Ser Arg 
        595                 600                 605             


Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro Ala Met Asp 
    610                 615                 620                 


Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr Asp Pro Leu 
625                 630                 635                 640 


Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr His Pro Glu 
                645                 650                 655     


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
            660                 665                 670         


Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala Ser Leu Glu 
        675                 680                 685             


Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu Tyr Gly Thr 
    690                 695                 700                 


Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu Leu Gly Asp 
705                 710                 715                 720 


Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly Leu Gly Val 
                725                 730                 735     


Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly Ala Ala Arg 
            740                 745                 750         


Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val Ala Ser Gly 
        755                 760                 765             


Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala 
    770                 775                 780                 


Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile 
785                 790                 795                 800 


Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys Ile Leu Ile 
                805                 810                 815     


Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr 
            820                 825                 830         


Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr Asp Glu Gly 
        835                 840                 845             


Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly Thr Gly Leu 
    850                 855                 860                 


Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly Leu Asp Pro 
865                 870                 875                 880 


Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr Ile Val Lys 
                885                 890                 895     


Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val Ser Ala Gly 
            900                 905                 910         


Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly Tyr Lys Val 
        915                 920                 925             


Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met Thr Leu Ala 
    930                 935                 940                 


Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala 
945                 950                 955                 960 


Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu Gly Asn Glu 
                965                 970                 975     


Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro Asn Met Asn 
            980                 985                 990         


Ala Val Ile Ser Leu Gln Lys Ile  Ile Glu Ile Gln Ser  Lys Tyr Trp 
        995                 1000                 1005             


Lys Ser  Val Arg Met Val Ala  Val Pro Arg Gly Cys  Ala Leu Ala 
    1010                 1015                 1020             


Gly Ala  Gln Leu Gln Glu Glu  Thr Glu Thr Val Ser  Ala Leu Ala 
    1025                 1030                 1035             


Ser Leu  Thr Val Asp Val Glu  Gln Pro Phe Ala Gln  Glu Asp Ser 
    1040                 1045                 1050             


Arg Thr  Ala Gly Glu Pro Met  Glu Glu Glu Pro Ala  Leu 
    1055                 1060                 1065     


<210>  41
<211>  4559
<212>  DNA
<213>  Homo sapiens

<400>  41
atggggtggc tggacgagag cagctcttgg ctcagcaaag aatgcacagt atgatcagct       60

cagtggatgt gaagtcagaa gttcctgtgg gcctggagcc catctcacct ttagacctaa      120

ggacagacct caggatgatg atgcccgtgg tggaccctgt tgtccgtgag aagcaattgc      180

agcaggaatt acttcttatc cagcagcagc aacaaatcca gaagcagctt ctgatagcag      240

agtttcagaa acagcatgag aacttgacac ggcagcacca ggctcagctt caggagcata      300

tcaagttgca acaggaactt ctagccataa aacagcaaca agaactccta gaaaaggagc      360

agaaactgga gcagcagagg caagaacagg aagtagagag gcatcgcaga gaacagcagc      420

ttcctcctct cagaggcaaa gatagaggac gagaaagggc agtggcaagt acagaagtaa      480

agcagaagct tcaagagttc ctactgagta aatcagcaac gaaagacact ccaactaatg      540

gaaaaaatca ttccgtgagc cgccatccca agctctggta cacggctgcc caccacacat      600

cattggatca aagctctcca ccccttagtg gaacatctcc atcctacaag tacacattac      660

caggagcaca agatgcaaag gatgatttcc cccttcgaaa aactgcctct gagcccaact      720

tgaaggtgcg gtccaggtta aaacagaaag tggcagagag gagaagcagc cccttactca      780

ggcggaagga tggaaatgtt gtcacttcat tcaagaagcg aatgtttgag gtgacagaat      840

cctcagtcag tagcagttct ccaggctctg gtcccagttc accaaacaat gggccaactg      900

gaagtgttac tgaaaatgag acttcggttt tgccccctac ccctcatgcc gagcaaatgg      960

tttcacagca acgcattcta attcatgaag attccatgaa cctgctaagt ctttatacct     1020

ctccttcttt gcccaacatt accttggggc ttcccgcagt gccatcccag ctcaatgctt     1080

cgaattcact caaagaaaag cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc     1140

tgcctgggca gtatggaggc agcatcccgg catcttccag ccaccctcat gttactttag     1200

agggaaagcc acccaacagc agccaccagg ctctcctgca gcatttatta ttgaaagaac     1260

aaatgcgaca gcaaaagctt cttgtagctg gtggagttcc cttacatcct cagtctccct     1320

tggcaacaaa agagagaatt tcacctggca ttagaggtac ccacaaattg ccccgtcaca     1380

gacccctgaa ccgaacccag tctgcacctt tgcctcagag cacgttggct cagctggtca     1440

ttcaacagca acaccagcaa ttcttggaga agcagaagca ataccagcag cagatccaca     1500

tgaacaaact gctttcgaaa tctattgaac aactgaagca accaggcagt caccttgagg     1560

aagcagagga agagcttcag ggggaccagg cgatgcagga agacagagcg ccctctagtg     1620

gcaacagcac taggagcgac agcagtgctt gtgtggatga cacactggga caagttgggg     1680

ctgtgaaggt caaggaggaa ccagtggaca gtgatgaaga tgctcagatc caggaaatgg     1740

aatctgggga gcaggctgct tttatgcaac agcctttcct ggaacccacg cacacacgtg     1800

cgctctctgt gcgccaagct ccgctggctg cggttggcat ggatggatta gagaaacacc     1860

gtctcgtctc caggactcac tcttcccctg ctgcctctgt tttacctcac ccagcaatgg     1920

accgccccct ccagcctggc tctgcaactg gaattgccta tgaccccttg atgctgaaac     1980

accagtgcgt ttgtggcaat tccaccaccc accctgagca tgctggacga atacagagta     2040

tctggtcacg actgcaagaa actgggctgc taaataaatg tgagcgaatt caaggtcgaa     2100

aagccagcct ggaggaaata cagcttgttc attctgaaca tcactcactg ttgtatggca     2160

ccaaccccct ggacggacag aagctggacc ccaggatact cctaggtgat gactctcaaa     2220

agtttttttc ctcattacct tgtggtggac ttggggtgga cagtgacacc atttggaatg     2280

agctacactc gtccggtgct gcacgcatgg ctgttggctg tgtcatcgag ctggcttcca     2340

aagtggcctc aggagagctg aagaatgggt ttgctgttgt gaggccccct ggccatcacg     2400

ctgaagaatc cacagccatg gggttctgct tttttaattc agttgcaatt accgccaaat     2460

acttgagaga ccaactaaat ataagcaaga tattgattgt agatctggat gttcaccatg     2520

gaaacggtac ccagcaggcc ttttatgctg accccagcat cctgtacatt tcactccatc     2580

gctatgatga agggaacttt ttccctggca gtggagcccc aaatgaggtt ggaacaggcc     2640

ttggagaagg gtacaatata aatattgcct ggacaggtgg ccttgatcct cccatgggag     2700

atgttgagta ccttgaagca ttcaggacca tcgtgaagcc tgtggccaaa gagtttgatc     2760

cagacatggt cttagtatct gctggatttg atgcattgga aggccacacc cctcctctag     2820

gagggtacaa agtgacggca aaatgttttg gtcatttgac gaagcaattg atgacattgg     2880

ctgatggacg tgtggtgttg gctctagaag gaggacatga tctcacagcc atctgtgatg     2940

catcagaagc ctgtgtaaat gcccttctag gaaatgagct ggagccactt gcagaagata     3000

ttctccacca aagcccgaat atgaatgctg ttatttcttt acagaagatc attgaaattc     3060

aaagcaagta ttggaagtca gtaaggatgg tggctgtgcc aaggggctgt gctctggctg     3120

gtgctcagtt gcaagaggag acagagaccg tttctgccct ggcctcccta acagtggatg     3180

tggaacagcc ctttgctcag gaagacagca gaactgctgg tgagcctatg gaagaggagc     3240

cagccttgtg aagtgccaag tccccctctg atatttcctg tgtgtgacat cattgtgtat     3300

ccccccaccc cagtaccctc agacatgtct tgtctgctgc ctgggtggca cagattcaat     3360

ggaacataaa cactgggcac aaaattctga acagcagctt cacttgttct ttggatggac     3420

ttgaaagggc attaaagatt ccttaaacgt aaccgctgtg attctagagt tacagtaaac     3480

cacgattgga agaaactgct tccagcatgc ttttaatatg ctgggtgacc cactcctaga     3540

caccaagttt gaactagaaa cattcagtac agcactagat attgttaatt tcagaagcta     3600

tgacagccag tgaaattttg ggcaaaacct gagacatagt cattcctgac attctgatca     3660

gctttttttg gggtaatttg tttttcaaac agtcttaact tgtttacaag atttgctttt     3720

agctatgaac ggatcgtaat tccacccaga atgtaatgtt tcttgtttgt ttgttttgtt     3780

ttgttagggt ttttttctca actttaacac acagttcaac tgttcctagt aaaagttcaa     3840

gatggaggaa ctagcatgag gcttttttca gtatctcgaa gtccaaatgc caaaggaacc     3900

tcacacactg tttgtaatgg tgcaatattt tatatcactt ttttttaaac atccccaaca     3960

tctttgtgtt ctcacacaca ggcaatttgc aatgttgcaa ttgtgttgga gaatgaagtc     4020

cccccacctc ccagccacac acacatcctt tgttctcatg acagtaggtc tgagcaaatg     4080

ttccaccaag cattttcagt gtctttgaaa agcacgtaac ttttcaaagg tggtcttaat     4140

ttgttgcata tctatcaagg acttattcac tcacctttcc ttttctgccc tctatcaatt     4200

gatttcttct tacctttcat cattcattcc ttcctttaga aaaactgaag attacccata     4260

atctcctctt attacttgag ggccttgact atttagttta ttttgtttac tttacaggtt     4320

aacacagttg ttttgtctga ttgcatttta ttaactgtga agccgttgaa atgaatatca     4380

cttaagcaac gttgctaaat ttctatgtgt ttgaaatgtg ttaatgaagg cactgcttat     4440

ttgtagtcac cttgaactga cttaacctag aagctgtgcc ttcttgtgaa aaaaaaaaaa     4500

aacaaaaaca aaaaacagcc tttaaacaag tttccttagt gtcaaaagtt aaaaataaa      4559


<210>  42
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  42

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala Ile 
                85                  90                  95      


Lys Gln Gln Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln 
            100                 105                 110         


Arg Gln Glu Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro 
        115                 120                 125             


Pro Leu Arg Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr 
    130                 135                 140                 


Glu Val Lys Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr 
145                 150                 155                 160 


Lys Asp Thr Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro 
                165                 170                 175     


Lys Leu Trp Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser 
            180                 185                 190         


Pro Pro Leu Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly 
        195                 200                 205             


Ala Gln Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu 
    210                 215                 220                 


Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg 
225                 230                 235                 240 


Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser 
                245                 250                 255     


Phe Lys Lys Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser 
            260                 265                 270         


Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser 
        275                 280                 285             


Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu 
    290                 295                 300                 


Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn 
305                 310                 315                 320 


Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 
                325                 330                 335     


Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu 
            340                 345                 350         


Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro 
        355                 360                 365             


Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val 
    370                 375                 380                 


Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln 
385                 390                 395                 400 


His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala 
                405                 410                 415     


Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg 
            420                 425                 430         


Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro 
        435                 440                 445             


Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln 
    450                 455                 460                 


Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln 
465                 470                 475                 480 


Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu 
                485                 490                 495     


Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu 
            500                 505                 510         


Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn 
        515                 520                 525             


Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln 
    530                 535                 540                 


Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp 
545                 550                 555                 560 


Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln 
                565                 570                 575     


Gln Pro Phe Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln 
            580                 585                 590         


Ala Pro Leu Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu 
        595                 600                 605             


Val Ser Arg Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro 
    610                 615                 620                 


Ala Met Asp Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr 
625                 630                 635                 640 


Asp Pro Leu Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr 
                645                 650                 655     


His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln 
            660                 665                 670         


Glu Thr Gly Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala 
        675                 680                 685             


Ser Leu Glu Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu 
    690                 695                 700                 


Tyr Gly Thr Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu 
705                 710                 715                 720 


Leu Gly Asp Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly 
                725                 730                 735     


Leu Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly 
            740                 745                 750         


Ala Ala Arg Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val 
        755                 760                 765             


Ala Ser Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly 
    770                 775                 780                 


His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser 
785                 790                 795                 800 


Val Ala Ile Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys 
                805                 810                 815     


Ile Leu Ile Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln 
            820                 825                 830         


Ala Phe Tyr Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr 
        835                 840                 845             


Asp Glu Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly 
    850                 855                 860                 


Thr Gly Leu Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly 
865                 870                 875                 880 


Leu Asp Pro Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr 
                885                 890                 895     


Ile Val Lys Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val 
            900                 905                 910         


Ser Ala Gly Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly 
        915                 920                 925             


Tyr Lys Val Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met 
    930                 935                 940                 


Thr Leu Ala Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp 
945                 950                 955                 960 


Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu 
                965                 970                 975     


Gly Asn Glu Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro 
            980                 985                 990         


Asn Met Asn Ala Val Ile Ser Leu  Gln Lys Ile Ile Glu  Ile Gln Ser 
        995                 1000                 1005             


Lys Tyr  Trp Lys Ser Val Arg  Met Val Ala Val Pro  Arg Gly Cys 
    1010                 1015                 1020             


Ala Leu  Ala Gly Ala Gln Leu  Gln Glu Glu Thr Glu  Thr Val Ser 
    1025                 1030                 1035             


Ala Leu  Ala Ser Leu Thr Val  Asp Val Glu Gln Pro  Phe Ala Gln 
    1040                 1045                 1050             


Glu Asp  Ser Arg Thr Ala Gly  Glu Pro Met Glu Glu  Glu Pro Ala 
    1055                 1060                 1065             


Leu 
    


<210>  43
<211>  2586
<212>  DNA
<213>  Homo sapiens

<400>  43
ccagcgtgct gaagccggag cgagctagcc gcccggagcc gcgccgaccc agctgagccc       60

agcccacggg acgccagacc tcgaccgtcg ctcctacccc ggccaccgct cggagccgag      120

gcggacgcgt cccgatcttc ccctgtcccc accctgcccc gaccctcctc tccacctctc      180

gcgtcgtgac accagctgtc tccggcagcc tcttggtcat gaaagccctc agattgtcgg      240

cttccgccct cttctgcctt ctgctgatca acgggttagg ggcagcaccc cctggtcgcc      300

ctgaggcgca gcctcctcct ctcagctctg agcataaaga gccggtagcc ggggacgcag      360

tgcccgggcc aaaggatggc agcgccccag aggtccgagg cgctcggaat tccgagccgc      420

aggacgaggg agagcttttc cagggcgtgg atccccgggc gctggccgcg gtgctgctgc      480

aggcactcga ccgtcccgcc tcacccccgg caccaagcgg ctcccagcag gggccggagg      540

aagaagcagc tgaagctctg ctgaccgaga ccgtgcgcag ccagacccac agcctcccgg      600

cgccggagag cccggagccc gcggctccgc ctcgccctca gactccggag aatgggcccg      660

aggcgagcga tccctccgag gagctcgagg cgctagcgtc cctgctccag gaactgcgag      720

atttcagtcc aagtagcgcc aagcgccagc aggagacggc ggcagcagag acggaaaccc      780

gcacgcacac gctgacccga gtgaatctgg agagcccggg gccagagcgc gtatggcgcg      840

cttcctgggg agagttccag gcgcgtgtcc cggagcgcgc gcccctgccg cccccggccc      900

cctctcaatt ccaggcgcgt atgcccgaca gcgggcccct tcccgaaacc cacaagttcg      960

gggaaggagt gtcctccccc aaaacacacc taggcgaggc attggcaccc ctgtccaagg     1020

cgtaccaagg cgtggccgcc ccgttcccca aggcgcgccg gccggagagc gcactcctgg     1080

gcggctccga ggcgggcgag cgccttctcc agcaagggct ggcgcaggtg gaggccgggc     1140

ggcggcaggc ggaggccacg cggcaggccg cggcgcagga agagcggctg gccgacctcg     1200

cctcggacct gctgctccag tatttgctgc agggcggggc ccggcagcgc ggcctcgggg     1260

gtcgggggct gcaggaggcg gcggaggagc gagagagtgc aagggaggag gaggaggcgg     1320

agcaggagag acgcggcggg gaggagaggg tgggggaaga ggatgaggag gcggccgagg     1380

cggaggcaga ggcggaggag gcggagaggg cgcggcagaa cgcgctcctg ttcgcggagg     1440

aggaggacgg ggaagccggc gccgaggaca agcgctccca ggaggagacg ccgggccacc     1500

ggcggaagga ggccgagggg acagaggagg gcggggagga ggaggacgac gaggagatgg     1560

atccgcagac gatcgacagc ctcattgagc tgtccaccaa actccacctg ccagcggacg     1620

acgtggtcag catcatcgag gaggtggagg agaagcggaa gcggaagaag aacgcccctc     1680

ccgagcccgt gccgcccccc cgtgccgccc ccgcccccac ccacgtccgc tccccgcagc     1740

ccccgccccc cgcccccgct cccgcacgag acgagctgcc ggactggaac gaggtgctcc     1800

cgccctggga tcgggaggag gacgaggtgt acccgccagg gccgtaccac cctttcccca     1860

actacatccg gccgcggaca ctgcagccgc cctcggcctt gcgccgccgc cactaccacc     1920

acgccttgcc gccttcgcgc cactatcccg gccgggaggc ccaggcgcgg cgcgcgcagg     1980

aggaggcgga ggcggaggag cgccggctgc aggagcagga ggagctggag aattacatcg     2040

agcacgtgct gctccggcgc ccgtgactgc ccttcccggt cccgcccccg cgcgcccccg     2100

ccgcgcgcgc gcgccggcgc ccccctccgt gttgcccgct ccccctcggt gtttgcatgc     2160

gccccggccc tgccccttgg ccctgcccct gtccccgggc tgcgtcggga cctgccagac     2220

ccccctcccg ggtcctgagc ccgaactccc agagctcacc cgcgggtgac cgggggccag     2280

cccaggaggg cgggtggttt gtgcgagttc ccttgccacg cggggccccg gccccatcaa     2340

gtccctctgg ggacgtcccc gtcggaaacc ggaaaaagca gttccagtta attgtgtgaa     2400

gtgtgtctgt ctccagccct tcgggcctcc cacgagcccc tccagcctct ccaagtcgct     2460

gtgaattgac cccttctttc ctttctctgt tgtaaatacc cctcacggag gaaatagttt     2520

tgctaagaaa taaaagtgac tattttatta ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2580

aaaaaa                                                                2586


<210>  44
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Ala Leu Arg Leu Ser Ala Ser Ala Leu Phe Cys Leu Leu Leu 
1               5                   10                  15      


Ile Asn Gly Leu Gly Ala Ala Pro Pro Gly Arg Pro Glu Ala Gln Pro 
            20                  25                  30          


Pro Pro Leu Ser Ser Glu His Lys Glu Pro Val Ala Gly Asp Ala Val 
        35                  40                  45              


Pro Gly Pro Lys Asp Gly Ser Ala Pro Glu Val Arg Gly Ala Arg Asn 
    50                  55                  60                  


Ser Glu Pro Gln Asp Glu Gly Glu Leu Phe Gln Gly Val Asp Pro Arg 
65                  70                  75                  80  


Ala Leu Ala Ala Val Leu Leu Gln Ala Leu Asp Arg Pro Ala Ser Pro 
                85                  90                  95      


Pro Ala Pro Ser Gly Ser Gln Gln Gly Pro Glu Glu Glu Ala Ala Glu 
            100                 105                 110         


Ala Leu Leu Thr Glu Thr Val Arg Ser Gln Thr His Ser Leu Pro Ala 
        115                 120                 125             


Pro Glu Ser Pro Glu Pro Ala Ala Pro Pro Arg Pro Gln Thr Pro Glu 
    130                 135                 140                 


Asn Gly Pro Glu Ala Ser Asp Pro Ser Glu Glu Leu Glu Ala Leu Ala 
145                 150                 155                 160 


Ser Leu Leu Gln Glu Leu Arg Asp Phe Ser Pro Ser Ser Ala Lys Arg 
                165                 170                 175     


Gln Gln Glu Thr Ala Ala Ala Glu Thr Glu Thr Arg Thr His Thr Leu 
            180                 185                 190         


Thr Arg Val Asn Leu Glu Ser Pro Gly Pro Glu Arg Val Trp Arg Ala 
        195                 200                 205             


Ser Trp Gly Glu Phe Gln Ala Arg Val Pro Glu Arg Ala Pro Leu Pro 
    210                 215                 220                 


Pro Pro Ala Pro Ser Gln Phe Gln Ala Arg Met Pro Asp Ser Gly Pro 
225                 230                 235                 240 


Leu Pro Glu Thr His Lys Phe Gly Glu Gly Val Ser Ser Pro Lys Thr 
                245                 250                 255     


His Leu Gly Glu Ala Leu Ala Pro Leu Ser Lys Ala Tyr Gln Gly Val 
            260                 265                 270         


Ala Ala Pro Phe Pro Lys Ala Arg Arg Pro Glu Ser Ala Leu Leu Gly 
        275                 280                 285             


Gly Ser Glu Ala Gly Glu Arg Leu Leu Gln Gln Gly Leu Ala Gln Val 
    290                 295                 300                 


Glu Ala Gly Arg Arg Gln Ala Glu Ala Thr Arg Gln Ala Ala Ala Gln 
305                 310                 315                 320 


Glu Glu Arg Leu Ala Asp Leu Ala Ser Asp Leu Leu Leu Gln Tyr Leu 
                325                 330                 335     


Leu Gln Gly Gly Ala Arg Gln Arg Gly Leu Gly Gly Arg Gly Leu Gln 
            340                 345                 350         


Glu Ala Ala Glu Glu Arg Glu Ser Ala Arg Glu Glu Glu Glu Ala Glu 
        355                 360                 365             


Gln Glu Arg Arg Gly Gly Glu Glu Arg Val Gly Glu Glu Asp Glu Glu 
    370                 375                 380                 


Ala Ala Glu Ala Glu Ala Glu Ala Glu Glu Ala Glu Arg Ala Arg Gln 
385                 390                 395                 400 


Asn Ala Leu Leu Phe Ala Glu Glu Glu Asp Gly Glu Ala Gly Ala Glu 
                405                 410                 415     


Asp Lys Arg Ser Gln Glu Glu Thr Pro Gly His Arg Arg Lys Glu Ala 
            420                 425                 430         


Glu Gly Thr Glu Glu Gly Gly Glu Glu Glu Asp Asp Glu Glu Met Asp 
        435                 440                 445             


Pro Gln Thr Ile Asp Ser Leu Ile Glu Leu Ser Thr Lys Leu His Leu 
    450                 455                 460                 


Pro Ala Asp Asp Val Val Ser Ile Ile Glu Glu Val Glu Glu Lys Arg 
465                 470                 475                 480 


Lys Arg Lys Lys Asn Ala Pro Pro Glu Pro Val Pro Pro Pro Arg Ala 
                485                 490                 495     


Ala Pro Ala Pro Thr His Val Arg Ser Pro Gln Pro Pro Pro Pro Ala 
            500                 505                 510         


Pro Ala Pro Ala Arg Asp Glu Leu Pro Asp Trp Asn Glu Val Leu Pro 
        515                 520                 525             


Pro Trp Asp Arg Glu Glu Asp Glu Val Tyr Pro Pro Gly Pro Tyr His 
    530                 535                 540                 


Pro Phe Pro Asn Tyr Ile Arg Pro Arg Thr Leu Gln Pro Pro Ser Ala 
545                 550                 555                 560 


Leu Arg Arg Arg His Tyr His His Ala Leu Pro Pro Ser Arg His Tyr 
                565                 570                 575     


Pro Gly Arg Glu Ala Gln Ala Arg Arg Ala Gln Glu Glu Ala Glu Ala 
            580                 585                 590         


Glu Glu Arg Arg Leu Gln Glu Gln Glu Glu Leu Glu Asn Tyr Ile Glu 
        595                 600                 605             


His Val Leu Leu Arg Arg Pro 
    610                 615 


<210>  45
<211>  1488
<212>  DNA
<213>  Homo sapiens

<400>  45
gccacgtcac tggctcaggc tcagctgctg ggtcaccagg agaatggacc cttcctccac       60

ctcagctcag agcacagtga tgattcgtga ctttcccaat agaacttcaa atctctgagg      120

acggggggtg gggggatgtg cttgagtgtt tgtactcatg gtcttgttct cggagtgaca      180

aagctggaac acaatacctc tatgcatgaa aaggttgtca cttgtcacaa ctaacaggct      240

ttcacctcaa ggaaattttc ttcccttgtg tacttttccc ctggcagtgg acatggctgc      300

actcttccaa gaagcaagca gctgtcccgt ctgctcagac tatctggaaa aaccaatgtc      360

cctggagtgt ggatgcaccg tctgcctcaa gtgcatcaat tcgctgcaga aggagcccca      420

tggggaggat ctgctttgct gttgctgttc catggtctct cagaggaaca aaatcaggcc      480

caatcggcag ctagagaggc tggtttccca catcaaggaa ctggagccca agctgaagaa      540

gattctacag atgaacccaa ggatgcggaa gttccaagtg gatatgacct tggatgccga      600

cacagccaac aacttcctcc tcatttctga cgacctcagg agcgtccgaa gtgggctcat      660

cacacagaat cggcaagacc ttgccgagag atttgacgtg tccgtttgca tcctgggctc      720

ccctcgcttt acctgtggcc gccactactg ggaggtggac gtgggaacaa gcacagaatg      780

ggacctggga gtctgcagag aatctgttca ctgcaaaggg aagatccagc tgaccacaga      840

gcttggattc tggactgtga gtttgaggga tggaagccgc ctctctgcca gcacggtgcc      900

gctgactttc ctcttagtag accgcaagtt acagcgagtg gggatttttc tggatatggg      960

catgcagaac gtttcctttt ttgatgctga aagtggttcc catgtctata cattcaggag     1020

cgtctctgct gaggagccac tgcgcccatt tttggctcct tcaattccac ctaatggtga     1080

tcaaggtgtc ttgagcatct gtcctttgat gaactcaggc actactgatg ctccagtccg     1140

tcctggggag gccaaataag ccgccactgc aaaaaaaaac agggtcagaa aattacttgg     1200

gtgggtagac ttaggaattt tctacttggt aaaagcatta tacagtcata ggagaaagat     1260

atgggacatt tctataatct atattctaat ttgattcgat tattgagtcg taagtattaa     1320

ttattgccac catccaactc attgagtctt atggttcaca tcttgtttcc tatagaaatg     1380

ttctgtattc tcggatcaat ttccaaatgc tttacttttt catttctgta agttcaaatc     1440

aatgtttaaa ttatagaagt tatgaggtaa ataaacattt ggatatca                  1488


<210>  46
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Arg Leu Ser Leu Val Thr Thr Asn Arg Leu Ser Pro Gln Gly 
1               5                   10                  15      


Asn Phe Leu Pro Leu Cys Thr Phe Pro Leu Ala Val Asp Met Ala Ala 
            20                  25                  30          


Leu Phe Gln Glu Ala Ser Ser Cys Pro Val Cys Ser Asp Tyr Leu Glu 
        35                  40                  45              


Lys Pro Met Ser Leu Glu Cys Gly Cys Thr Val Cys Leu Lys Cys Ile 
    50                  55                  60                  


Asn Ser Leu Gln Lys Glu Pro His Gly Glu Asp Leu Leu Cys Cys Cys 
65                  70                  75                  80  


Cys Ser Met Val Ser Gln Arg Asn Lys Ile Arg Pro Asn Arg Gln Leu 
                85                  90                  95      


Glu Arg Leu Val Ser His Ile Lys Glu Leu Glu Pro Lys Leu Lys Lys 
            100                 105                 110         


Ile Leu Gln Met Asn Pro Arg Met Arg Lys Phe Gln Val Asp Met Thr 
        115                 120                 125             


Leu Asp Ala Asp Thr Ala Asn Asn Phe Leu Leu Ile Ser Asp Asp Leu 
    130                 135                 140                 


Arg Ser Val Arg Ser Gly Leu Ile Thr Gln Asn Arg Gln Asp Leu Ala 
145                 150                 155                 160 


Glu Arg Phe Asp Val Ser Val Cys Ile Leu Gly Ser Pro Arg Phe Thr 
                165                 170                 175     


Cys Gly Arg His Tyr Trp Glu Val Asp Val Gly Thr Ser Thr Glu Trp 
            180                 185                 190         


Asp Leu Gly Val Cys Arg Glu Ser Val His Cys Lys Gly Lys Ile Gln 
        195                 200                 205             


Leu Thr Thr Glu Leu Gly Phe Trp Thr Val Ser Leu Arg Asp Gly Ser 
    210                 215                 220                 


Arg Leu Ser Ala Ser Thr Val Pro Leu Thr Phe Leu Leu Val Asp Arg 
225                 230                 235                 240 


Lys Leu Gln Arg Val Gly Ile Phe Leu Asp Met Gly Met Gln Asn Val 
                245                 250                 255     


Ser Phe Phe Asp Ala Glu Ser Gly Ser His Val Tyr Thr Phe Arg Ser 
            260                 265                 270         


Val Ser Ala Glu Glu Pro Leu Arg Pro Phe Leu Ala Pro Ser Ile Pro 
        275                 280                 285             


Pro Asn Gly Asp Gln Gly Val Leu Ser Ile Cys Pro Leu Met Asn Ser 
    290                 295                 300                 


Gly Thr Thr Asp Ala Pro Val Arg Pro Gly Glu Ala Lys 
305                 310                 315         


<210>  47
<211>  1214
<212>  DNA
<213>  Homo sapiens

<400>  47
cggcagcagc gagtggacat ggctgcactc ttccaagaag caagcagctg tcccgtctgc       60

tcagactatc tggaaaaacc aatgtccctg gagtgtggat gcaccgtctg cctcaagtgc      120

atcaattcgc tgcagaagga gccccatggg gaggatctgc tttgctgttg ctgttccatg      180

gtctctcaga ggaacaaaat caggcccaat cggcagctag agaggctggt ttcccacatc      240

aaggaactgg agcccaagct gaagaagatt ctacagatga acccaaggat gcggaagttc      300

caagtggata tgaccttgga tgccgacaca gccaacaact tcctcctcat ttctgacgac      360

ctcaggagcg tccgaagtgg gctcatcaca cagaatcggc aagaccttgc cgagagattt      420

gacgtgtccg tttgcatcct gggctcccct cgctttacct gtggccgcca ctactgggag      480

gtggacgtgg gaacaagcac agaatgggac ctgggagtct gcagagaatc tgttcactgc      540

aaagggaaga tccagctgac cacagagctt ggattctgga ctgtgagttt gagggatgga      600

agccgcctct ctgccagcac ggtgccgctg actttcctct tagtagaccg caagttacag      660

cgagtgggga tttttctgga tatgggcatg cagaacgttt ccttttttga tgctgaaagt      720

ggttcccatg tctatacatt caggagcgtc tctgctgagg agccactgcg cccatttttg      780

gctccttcaa ttccacctaa tggtgatcaa ggtgtcttga gcatctgtcc tttgatgaac      840

tcaggcacta ctgatgctcc agtccgtcct ggggaggcca aataagccgc cactgcaaaa      900

aaaaacaggg tcagaaaatt acttgggtgg gtagacttag gaattttcta cttggtaaaa      960

gcattataca gtcataggag aaagatatgg gacatttcta taatctatat tctaatttga     1020

ttcgattatt gagtcgtaag tattaattat tgccaccatc caactcattg agtcttatgg     1080

ttcacatctt gtttcctata gaaatgttct gtattctcgg atcaatttcc aaatgcttta     1140

ctttttcatt tctgtaagtt caaatcaatg tttaaattat agaagttatg aggtaaataa     1200

acatttggat atca                                                       1214


<210>  48
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Ala Leu Phe Gln Glu Ala Ser Ser Cys Pro Val Cys Ser Asp 
1               5                   10                  15      


Tyr Leu Glu Lys Pro Met Ser Leu Glu Cys Gly Cys Thr Val Cys Leu 
            20                  25                  30          


Lys Cys Ile Asn Ser Leu Gln Lys Glu Pro His Gly Glu Asp Leu Leu 
        35                  40                  45              


Cys Cys Cys Cys Ser Met Val Ser Gln Arg Asn Lys Ile Arg Pro Asn 
    50                  55                  60                  


Arg Gln Leu Glu Arg Leu Val Ser His Ile Lys Glu Leu Glu Pro Lys 
65                  70                  75                  80  


Leu Lys Lys Ile Leu Gln Met Asn Pro Arg Met Arg Lys Phe Gln Val 
                85                  90                  95      


Asp Met Thr Leu Asp Ala Asp Thr Ala Asn Asn Phe Leu Leu Ile Ser 
            100                 105                 110         


Asp Asp Leu Arg Ser Val Arg Ser Gly Leu Ile Thr Gln Asn Arg Gln 
        115                 120                 125             


Asp Leu Ala Glu Arg Phe Asp Val Ser Val Cys Ile Leu Gly Ser Pro 
    130                 135                 140                 


Arg Phe Thr Cys Gly Arg His Tyr Trp Glu Val Asp Val Gly Thr Ser 
145                 150                 155                 160 


Thr Glu Trp Asp Leu Gly Val Cys Arg Glu Ser Val His Cys Lys Gly 
                165                 170                 175     


Lys Ile Gln Leu Thr Thr Glu Leu Gly Phe Trp Thr Val Ser Leu Arg 
            180                 185                 190         


Asp Gly Ser Arg Leu Ser Ala Ser Thr Val Pro Leu Thr Phe Leu Leu 
        195                 200                 205             


Val Asp Arg Lys Leu Gln Arg Val Gly Ile Phe Leu Asp Met Gly Met 
    210                 215                 220                 


Gln Asn Val Ser Phe Phe Asp Ala Glu Ser Gly Ser His Val Tyr Thr 
225                 230                 235                 240 


Phe Arg Ser Val Ser Ala Glu Glu Pro Leu Arg Pro Phe Leu Ala Pro 
                245                 250                 255     


Ser Ile Pro Pro Asn Gly Asp Gln Gly Val Leu Ser Ile Cys Pro Leu 
            260                 265                 270         


Met Asn Ser Gly Thr Thr Asp Ala Pro Val Arg Pro Gly Glu Ala Lys 
        275                 280                 285             


<210>  49
<211>  1508
<212>  DNA
<213>  Homo sapiens

<400>  49
attctcagcg ctgggagccg ccgcccccgc agctgctgcc gccgccgcca gggcccggac       60

tcggacgcgt gccccaggat gggtgagttc aacgagaaga agacaacatg tggcaccgtt      120

tgcctcaagt acctgctgtt tacctacaat tgctgcttct ggctggctgg cctggctgtc      180

atggcagtgg gcatctggac gctggccctc aagagtgact acatcagcct gctggcctca      240

ggcacctacc tggccacagc ctacatcctg gtggtggcgg gcactgtcgt catggtgact      300

ggggtcttgg gctgctgcgc caccttcaag gagcgtcgga acctgctgcg cctgtacttc      360

atcctgctcc tcatcatctt tctgctggag atcatcgctg gtatcctcgc ctacgcctac      420

taccagcagc tgaacacgga gctcaaggag aacctgaagg acaccatgac caagcgctac      480

caccagccgg gccatgaggc tgtgaccagc gctgtggacc agctgcagca ggagttccac      540

tgctgtggca gcaacaactc acaggactgg cgagacagtg agtggatccg ctcacaggag      600

gccggtggcc gtgtggtccc agacagctgc tgcaagacgg tggtggctct ttgtgggcag      660

cgagaccatg cctccaacat ctacaaggtg gagggcggct gcatcaccaa gttggagacc      720

ttcatccagg agcacctgag ggtcattggg gctgtgggga tcggcattgc ctgtgtgcag      780

gtctttggca tgatcttcac gtgctgcctg tacaggagtc tcaagctgga gcactactga      840

ccctgccttg ggccttgctg ctgctgcacc caactactga gctgagacca ctgagtacca      900

ggggctgggc tccctgatga cacccaccct gtgccatcac cataacctct ggggacccca      960

acctcagagg cagcttcaag tgccttttgc tgcgcaccaa tgcccagcag gggaggtgag     1020

gggggctggc ggggcgaagt ttggggggtg ttttgtgggg ctccccagac acactctctg     1080

cctggtggtc agatgcaggt tggaaggggc cttgctgagt ggcgcaaggc cgagcgttcc     1140

cagcaggggg agaaaccctt cacaccccag gcccttcagg aactggggcc ttgccttgca     1200

gccacatggc cccatcccag ttggggaagc caggtgagct ctgacccttg ggcctgggcc     1260

tctgcccctc ccaacccagc cctcgtctcc ctcgacagcg cccctgctgt cttccccacc     1320

gcagtcacca ccacccgaaa tgccacgtgg tcactgtgca ctgccctgtt catgtgcctc     1380

tgcggggcag ggccttcctg gttttgttca ctgctgtacc cagatgccta caaccatccc     1440

tgccacatac aggtgctcaa taaacacttg tagagcagat ggaaaaaaaa aaaaaaaaaa     1500

aaaaaaaa                                                              1508


<210>  50
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  51
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  51
attctcagcg ctgggagccg ccgcccccgc agctgctgcc gccgccgcca gggcccggac       60

tcggacgcgt ggtagcctag agtcctgggg agcttctgtc cacctgtcct gcagaggagt      120

cgtttccagc ccggctgccc caggatgggt gagttcaacg agaagaagac aacatgtggc      180

accgtttgcc tcaagtacct gctgtttacc tacaattgct gcttctggct ggctggcctg      240

gctgtcatgg cagtgggcat ctggacgctg gccctcaaga gtgactacat cagcctgctg      300

gcctcaggca cctacctggc cacagcctac atcctggtgg tggcgggcac tgtcgtcatg      360

gtgactgggg tcttgggctg ctgcgccacc ttcaaggagc gtcggaacct gctgcgcctg      420

tacttcatcc tgctcctcat catctttctg ctggagatca tcgctggtat cctcgcctac      480

gcctactacc agcagctgaa cacggagctc aaggagaacc tgaaggacac catgaccaag      540

cgctaccacc agccgggcca tgaggctgtg accagcgctg tggaccagct gcagcaggag      600

ttccactgct gtggcagcaa caactcacag gactggcgag acagtgagtg gatccgctca      660

caggaggccg gtggccgtgt ggtcccagac agctgctgca agacggtggt ggctctttgt      720

gggcagcgag accatgcctc caacatctac aaggtggagg gcggctgcat caccaagttg      780

gagaccttca tccaggagca cctgagggtc attggggctg tggggatcgg cattgcctgt      840

gtgcaggtct ttggcatgat cttcacgtgc tgcctgtaca ggagtctcaa gctggagcac      900

tactgaccct gccttgggcc ttgctgctgc tgcacccaac tactgagctg agaccactga      960

gtaccagggg ctgggctccc tgatgacacc caccctgtgc catcaccata acctctgggg     1020

accccaacct cagaggcagc ttcaagtgcc ttttgctgcg caccaatgcc cagcagggga     1080

ggtgaggggg gctggcgggg cgaagtttgg ggggtgtttt gtggggctcc ccagacacac     1140

tctctgcctg gtggtcagat gcaggttgga aggggccttg ctgagtggcg caaggccgag     1200

cgttcccagc agggggagaa acccttcaca ccccaggccc ttcaggaact ggggccttgc     1260

cttgcagcca catggcccca tcccagttgg ggaagccagg tgagctctga cccttgggcc     1320

tgggcctctg cccctcccaa cccagccctc gtctccctcg acagcgcccc tgctgtcttc     1380

cccaccgcag tcaccaccac ccgaaatgcc acgtggtcac tgtgcactgc cctgttcatg     1440

tgcctctgcg gggcagggcc ttcctggttt tgttcactgc tgtacccaga tgcctacaac     1500

catccctgcc acatacaggt gctcaataaa cacttgtaga gcagatggaa aaaaaaaaaa     1560

aaaaaaaaaa aaaa                                                       1574


<210>  52
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  53
<211>  1570
<212>  DNA
<213>  Homo sapiens

<400>  53
attctcagcg ctgggagccg ccgcccccgc agctgctgcc gccgccgcca gggcccggac       60

tcggacgcgt gcctagagtc ctggggagct tctgtccacc tgtcctgcag aggagtcgtt      120

tccagcccgg ctgccccagg atgggtgagt tcaacgagaa gaagacaaca tgtggcaccg      180

tttgcctcaa gtacctgctg tttacctaca attgctgctt ctggctggct ggcctggctg      240

tcatggcagt gggcatctgg acgctggccc tcaagagtga ctacatcagc ctgctggcct      300

caggcaccta cctggccaca gcctacatcc tggtggtggc gggcactgtc gtcatggtga      360

ctggggtctt gggctgctgc gccaccttca aggagcgtcg gaacctgctg cgcctgtact      420

tcatcctgct cctcatcatc tttctgctgg agatcatcgc tggtatcctc gcctacgcct      480

actaccagca gctgaacacg gagctcaagg agaacctgaa ggacaccatg accaagcgct      540

accaccagcc gggccatgag gctgtgacca gcgctgtgga ccagctgcag caggagttcc      600

actgctgtgg cagcaacaac tcacaggact ggcgagacag tgagtggatc cgctcacagg      660

aggccggtgg ccgtgtggtc ccagacagct gctgcaagac ggtggtggct ctttgtgggc      720

agcgagacca tgcctccaac atctacaagg tggagggcgg ctgcatcacc aagttggaga      780

ccttcatcca ggagcacctg agggtcattg gggctgtggg gatcggcatt gcctgtgtgc      840

aggtctttgg catgatcttc acgtgctgcc tgtacaggag tctcaagctg gagcactact      900

gaccctgcct tgggccttgc tgctgctgca cccaactact gagctgagac cactgagtac      960

caggggctgg gctccctgat gacacccacc ctgtgccatc accataacct ctggggaccc     1020

caacctcaga ggcagcttca agtgcctttt gctgcgcacc aatgcccagc aggggaggtg     1080

aggggggctg gcggggcgaa gtttgggggg tgttttgtgg ggctccccag acacactctc     1140

tgcctggtgg tcagatgcag gttggaaggg gccttgctga gtggcgcaag gccgagcgtt     1200

cccagcaggg ggagaaaccc ttcacacccc aggcccttca ggaactgggg ccttgccttg     1260

cagccacatg gccccatccc agttggggaa gccaggtgag ctctgaccct tgggcctggg     1320

cctctgcccc tcccaaccca gccctcgtct ccctcgacag cgcccctgct gtcttcccca     1380

ccgcagtcac caccacccga aatgccacgt ggtcactgtg cactgccctg ttcatgtgcc     1440

tctgcggggc agggccttcc tggttttgtt cactgctgta cccagatgcc tacaaccatc     1500

cctgccacat acaggtgctc aataaacact tgtagagcag atggaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa                                                            1570


<210>  54
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  55
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  55
attctcagcg ctgggagccg ccgcccccgc agctgctgcc gccgccgcca gggcccggac       60

tcggacgcgt ggtagcccca ggatgggtga gttcaacgag aagaagacaa catgtggcac      120

cgtttgcctc aagtacctgc tgtttaccta caattgctgc ttctggctgg ctggcctggc      180

tgtcatggca gtgggcatct ggacgctggc cctcaagagt gactacatca gcctgctggc      240

ctcaggcacc tacctggcca cagcctacat cctggtggtg gcgggcactg tcgtcatggt      300

gactggggtc ttgggctgct gcgccacctt caaggagcgt cggaacctgc tgcgcctgta      360

cttcatcctg ctcctcatca tctttctgct ggagatcatc gctggtatcc tcgcctacgc      420

ctactaccag cagctgaaca cggagctcaa ggagaacctg aaggacacca tgaccaagcg      480

ctaccaccag ccgggccatg aggctgtgac cagcgctgtg gaccagctgc agcaggagtt      540

ccactgctgt ggcagcaaca actcacagga ctggcgagac agtgagtgga tccgctcaca      600

ggaggccggt ggccgtgtgg tcccagacag ctgctgcaag acggtggtgg ctctttgtgg      660

gcagcgagac catgcctcca acatctacaa ggtggagggc ggctgcatca ccaagttgga      720

gaccttcatc caggagcacc tgagggtcat tggggctgtg gggatcggca ttgcctgtgt      780

gcaggtcttt ggcatgatct tcacgtgctg cctgtacagg agtctcaagc tggagcacta      840

ctgaccctgc cttgggcctt gctgctgctg cacccaacta ctgagctgag accactgagt      900

accaggggct gggctccctg atgacaccca ccctgtgcca tcaccataac ctctggggac      960

cccaacctca gaggcagctt caagtgcctt ttgctgcgca ccaatgccca gcaggggagg     1020

tgaggggggc tggcggggcg aagtttgggg ggtgttttgt ggggctcccc agacacactc     1080

tctgcctggt ggtcagatgc aggttggaag gggccttgct gagtggcgca aggccgagcg     1140

ttcccagcag ggggagaaac ccttcacacc ccaggccctt caggaactgg ggccttgcct     1200

tgcagccaca tggccccatc ccagttgggg aagccaggtg agctctgacc cttgggcctg     1260

ggcctctgcc cctcccaacc cagccctcgt ctccctcgac agcgcccctg ctgtcttccc     1320

caccgcagtc accaccaccc gaaatgccac gtggtcactg tgcactgccc tgttcatgtg     1380

cctctgcggg gcagggcctt cctggttttg ttcactgctg tacccagatg cctacaacca     1440

tccctgccac atacaggtgc tcaataaaca cttgtagagc agatggaaaa aaaaaaaaaa     1500

aaaaaaaaaa aa                                                         1512


<210>  56
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  57
<211>  1987
<212>  DNA
<213>  Homo sapiens

<400>  57
accagtatgt cagtgtttga catcaactgc accactgata cacgagtcgg aatttgagct       60

tctacaagta cattccttcc taggccaaac actgacgcta agaaatacga gaacagatca      120

tcgctaaaca gcagctgaag gtcaggcgaa ctgactcgct gcggaatctg cctttgcacg      180

tgatcagtcg gacgtctaca cccgcagccg tcttctgtct ccgcctcacc ctcaggcctg      240

acggtccgag tggagctgcg ggacagcccg aacctccagg tcagccccgc ggccctccat      300

ggcgctggtg cgcgcactcg tctgctgcct gctgactgcc tggcactgcc gctccggcct      360

cgggctgccc gtggcgcccg caggcggcag gaatcctcct ccggcgatag gacagttttg      420

gcatgtgact gacttacact tagaccctac ttaccacatc acagatgacc acacaaaagt      480

gtgtgcttca tctaaaggtg caaatgcctc caaccctggc ccttttggag atgttctgtg      540

tgattctcca tatcaactta ttttgtcagc atttgatttt attaaaaatt ctggacaaga      600

agcatctttc atgatatgga caggggatag cccacctcat gttcctgtac ctgaactctc      660

aacagacact gttataaatg tgatcactaa tatgacaacc accatccaga gtctctttcc      720

aaatctccag gttttccctg cgctgggtaa tcatgactat tggccacagg atcaactgcc      780

tgtagtcacc agtaaagtgt acaatgcagt agcaaacctc tggaaaccat ggctagatga      840

agaagctatt agtactttaa ggaaaggtgg tttttattca cagaaagtta caactaatcc      900

aaaccttagg atcatcagtc taaacacaaa cttgtactac ggcccaaata taatgacact      960

gaacaagact gacccagcca accagtttga atggctagaa agtacattga acaactctca     1020

gcagaataag gagaaggtgt atatcatagc acatgttcca gtggggtatc tgccatcttc     1080

acagaacatc acagcaatga gagaatacta taatgagaaa ttgatagata tttttcaaaa     1140

atacagtgat gtcattgcag gacaatttta tggacacact cacagagaca gcattatggt     1200

tctttcagat aaaaaaggaa gtccagtaaa ttctttgttt gtggctcctg ctgttacacc     1260

agtgaagagt gttttagaaa aacagaccaa caatcctggt atcagactgt ttcagtatga     1320

tcctcgtgat tataaattat tggatatgtt gcagtattac ttgaatctga cagaggcgaa     1380

tctaaaggga gagtccatct ggaagctgga gtatatcctg acccagacct acgacattga     1440

agatttgcag ccggaaagtt tatatggatt agctaaacaa tttacaatcc tagacagtaa     1500

gcagtttata aaatactaca attacttctt tgtgagttat gacagcagtg taacatgtga     1560

taagacatgt aaggcctttc agatttgtgc aattatgaat cttgataata tttcctatgc     1620

agattgcctc aaacagcttt atataaagca caattactag tatttcacag tttttgctaa     1680

tagaaaatgc tgattctgat tctgagatca atttgtggga attttacata aatctttgtt     1740

aattactgag tgggcaagta gacttcctgt ctttgctttc tttttttttt tctttttgat     1800

gccttaatgt agatatcttt atcattctga attgtattat atatttaaag tgctcattaa     1860

tagaatgatg gatgtaaatt ggatgtaaat attcagttta tataattata tctaatttgt     1920

acccttgttg aaattgtcat ttatacaata aagcgaattc tttatctcta aaaaaaaaaa     1980

aaaaaaa                                                               1987


<210>  58
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Leu Val Arg Ala Leu Val Cys Cys Leu Leu Thr Ala Trp His 
1               5                   10                  15      


Cys Arg Ser Gly Leu Gly Leu Pro Val Ala Pro Ala Gly Gly Arg Asn 
            20                  25                  30          


Pro Pro Pro Ala Ile Gly Gln Phe Trp His Val Thr Asp Leu His Leu 
        35                  40                  45              


Asp Pro Thr Tyr His Ile Thr Asp Asp His Thr Lys Val Cys Ala Ser 
    50                  55                  60                  


Ser Lys Gly Ala Asn Ala Ser Asn Pro Gly Pro Phe Gly Asp Val Leu 
65                  70                  75                  80  


Cys Asp Ser Pro Tyr Gln Leu Ile Leu Ser Ala Phe Asp Phe Ile Lys 
                85                  90                  95      


Asn Ser Gly Gln Glu Ala Ser Phe Met Ile Trp Thr Gly Asp Ser Pro 
            100                 105                 110         


Pro His Val Pro Val Pro Glu Leu Ser Thr Asp Thr Val Ile Asn Val 
        115                 120                 125             


Ile Thr Asn Met Thr Thr Thr Ile Gln Ser Leu Phe Pro Asn Leu Gln 
    130                 135                 140                 


Val Phe Pro Ala Leu Gly Asn His Asp Tyr Trp Pro Gln Asp Gln Leu 
145                 150                 155                 160 


Pro Val Val Thr Ser Lys Val Tyr Asn Ala Val Ala Asn Leu Trp Lys 
                165                 170                 175     


Pro Trp Leu Asp Glu Glu Ala Ile Ser Thr Leu Arg Lys Gly Gly Phe 
            180                 185                 190         


Tyr Ser Gln Lys Val Thr Thr Asn Pro Asn Leu Arg Ile Ile Ser Leu 
        195                 200                 205             


Asn Thr Asn Leu Tyr Tyr Gly Pro Asn Ile Met Thr Leu Asn Lys Thr 
    210                 215                 220                 


Asp Pro Ala Asn Gln Phe Glu Trp Leu Glu Ser Thr Leu Asn Asn Ser 
225                 230                 235                 240 


Gln Gln Asn Lys Glu Lys Val Tyr Ile Ile Ala His Val Pro Val Gly 
                245                 250                 255     


Tyr Leu Pro Ser Ser Gln Asn Ile Thr Ala Met Arg Glu Tyr Tyr Asn 
            260                 265                 270         


Glu Lys Leu Ile Asp Ile Phe Gln Lys Tyr Ser Asp Val Ile Ala Gly 
        275                 280                 285             


Gln Phe Tyr Gly His Thr His Arg Asp Ser Ile Met Val Leu Ser Asp 
    290                 295                 300                 


Lys Lys Gly Ser Pro Val Asn Ser Leu Phe Val Ala Pro Ala Val Thr 
305                 310                 315                 320 


Pro Val Lys Ser Val Leu Glu Lys Gln Thr Asn Asn Pro Gly Ile Arg 
                325                 330                 335     


Leu Phe Gln Tyr Asp Pro Arg Asp Tyr Lys Leu Leu Asp Met Leu Gln 
            340                 345                 350         


Tyr Tyr Leu Asn Leu Thr Glu Ala Asn Leu Lys Gly Glu Ser Ile Trp 
        355                 360                 365             


Lys Leu Glu Tyr Ile Leu Thr Gln Thr Tyr Asp Ile Glu Asp Leu Gln 
    370                 375                 380                 


Pro Glu Ser Leu Tyr Gly Leu Ala Lys Gln Phe Thr Ile Leu Asp Ser 
385                 390                 395                 400 


Lys Gln Phe Ile Lys Tyr Tyr Asn Tyr Phe Phe Val Ser Tyr Asp Ser 
                405                 410                 415     


Ser Val Thr Cys Asp Lys Thr Cys Lys Ala Phe Gln Ile Cys Ala Ile 
            420                 425                 430         


Met Asn Leu Asp Asn Ile Ser Tyr Ala Asp Cys Leu Lys Gln Leu Tyr 
        435                 440                 445             


Ile Lys His Asn Tyr 
    450             


<210>  59
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  59
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210>  60
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  61
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  61
gagaacctgg agcctaaggt ttaggctcac ccatttcaac cagtctagca gcatctgcaa       60

catctacaat ggccttgacc tttgctttac tggtggccct cctggtgctc agctgcaagt      120

caagctgctc tgtgggctgt gatctgcctc aaacccacag cctgggtagc aggaggacct      180

tgatgctcct ggcacagatg aggagaatct ctcttttctc ctgcttgaag gacagacatg      240

actttggatt tccccaggag gagtttggca accagttcca aaaggctgaa accatccctg      300

tcctccatga gatgatccag cagatcttca atctcttcag cacaaaggac tcatctgctg      360

cttgggatga gaccctccta gacaaattct acactgaact ctaccagcag ctgaatgacc      420

tggaagcctg tgtgatacag ggggtggggg tgacagagac tcccctgatg aaggaggact      480

ccattctggc tgtgaggaaa tacttccaaa gaatcactct ctatctgaaa gagaagaaat      540

acagcccttg tgcctgggag gttgtcagag cagaaatcat gagatctttt tctttgtcaa      600

caaacttgca agaaagttta agaagtaagg aatgaaaact ggttcaacat ggaaatgatt      660

ttcattgatt cgtatgccag ctcacctttt tatgatctgc catttcaaag actcatgttt      720

ctgctatgac catgacacga tttaaatctt ttcaaatgtt tttaggagta ttaatcaaca      780

ttgtattcag ctcttaaggc actagtccct tacagaggac catgctgact gatccattat      840

ctatttaaat atttttaaaa tattatttat ttaactattt ataaaacaac ttatttttgt      900

tcatattatg tcatgtgcac ctttgcacag tggttaatgt aataaaatat gttctttgta      960

tttggtaaat ttattttgtg ttgttcattg aacttttgct atggaaactt ttgtacttgt     1020

ttattcttta aaatgaaatt ccaagcctaa ttgtgcaacc tgattacaga ataactggta     1080

cacttcattt atccatcaat attatattca agatataagt aaaaataaac tttctgtaaa     1140

cca                                                                   1143


<210>  62
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  63
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  63
agaaaaccta gaggccgaag ttcaaggtta tccatctcaa gtagcctagc aatatttgca       60

acatcccaat ggccctgtcc ttttctttac tgatggccgt gctggtgctc agctacaaat      120

ccatctgttc tctgggctgt gatctgcctc agacccacag cctgggtaat aggagggcct      180

tgatactcct ggcacaaatg ggaagaatct ctcatttctc ctgcctgaag gacagacatg      240

atttcggatt ccccgaggag gagtttgatg gccaccagtt ccagaaggct caagccatct      300

ctgtcctcca tgagatgatc cagcagacct tcaatctctt cagcacagag gactcatctg      360

ctgcttggga acagagcctc ctagaaaaat tttccactga actttaccag caactgaatg      420

acctggaagc atgtgtgata caggaggttg gggtggaaga gactcccctg atgaatgagg      480

actccatcct ggctgtgagg aaatacttcc aaagaatcac tctttatcta acagagaaga      540

aatacagccc ttgtgcctgg gaggttgtca gagcagaaat catgagatcc ctctcgtttt      600

caacaaactt gcaaaaaaga ttaaggagga aggattgaaa cctggttcaa catggaaatg      660

atcctgattg actaatacat tatctcacac tttcatgagt tcttccattt caaagactca      720

cttctataac caccacgagt tgaatcaaaa ttttcaaatg ttttcagcag tgtgaagaag      780

cttggtgtat acctgtgcag gcactagtcc tttacagatg acaatgctga tgtctctgtt      840

catctattta tttaaatatt tatttatttt taaaatttaa attatttttt atgtgatatc      900

atgagtacct ttacattgtg gtgaatgtaa caatatatgt tcttcatatt tagccaatat      960

attaatttcc tttttcatta aa                                               982


<210>  64
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  65
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  65
gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg       60

gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct      120

ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg      180

gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt      240

cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat      300

gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat      360

gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc      420

tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg      480

actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct      540

tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg      600

caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga      660

ctagtacacc atttcacact tcttgagttc tgccgtttca                            700


<210>  66
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  67
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  67
atggctttgc cttttgcttt actgatggcc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctggact gtgatctgcc tcagacccac agcctgggtc acaggaggac catgatgctc      120

ctggcacaaa tgaggagaat ctctcttttc tcctgtctga aggacagaca tgacttcaga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctgaagccat ctctgtcctc      240

catgaggtga ttcagcagac cttcaacctc ttcagcacaa aggactcatc tgttgcttgg      300

gatgagaggc ttctagacaa actctatact gaactttacc agcagctgaa tgacctggaa      360

gcctgtgtga tgcaggaggt gtgggtggga gggactcccc tgatgaatga ggactccatc      420

ctggctgtga gaaaatactt ccaaagaatc actctctacc tgacagagaa aaagtacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttc atcaagaaac      540

ttgcaagaaa ggttaaggag gaaggaataa                                       570


<210>  68
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  69
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  69
tacccacctc aggtagccta gtgatatttg caaaatccca atggcccggt ccttttcttt       60

actgatggtc gtgctggtac tcagctacaa atccatctgc tctctgggct gtgatctgcc      120

tcagacccac agcctgcgta ataggagggc cttgatactc ctggcacaaa tgggaagaat      180

ctctcctttc tcctgcttga aggacagaca tgaattcaga ttcccagagg aggagtttga      240

tggccaccag ttccagaaga ctcaagccat ctctgtcctc catgagatga tccagcagac      300

cttcaatctc ttcagcacag aggactcatc tgctgcttgg gaacagagcc tcctagaaaa      360

attttccact gaactttacc agcaactgaa tgacctggaa gcatgtgtga tacaggaggt      420

tggggtggaa gagactcccc tgatgaatga ggacttcatc ctggctgtga ggaaatactt      480

ccaaagaatc actctttatc taatggagaa gaaatacagc ccttgtgcct gggaggttgt      540

cagagcagaa atcatgagat ccttctcttt ttcaacaaac ttgaaaaaag gattaaggag      600

gaaggattga aaactggttc atcatggaaa tgattctcat tgactaatgc atcatctcac      660

actttcatga gttcttccat ttcaaagact cacttctata accaccacaa gttaatcaaa      720

atttccaaat gttttc                                                      736


<210>  70
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  71
<211>  1039
<212>  DNA
<213>  Homo sapiens

<400>  71
accagctcag cagcatccac aacatctaca atggccttga ctttttattt actggtggcc       60

ctagtggtgc tcagctacaa gtcattcagc tctctgggct gtgatctgcc tcagactcac      120

agcctgggta acaggagggc cttgatactc ctggcacaaa tgcgaagaat ctctcctttc      180

tcctgcctga aggacagaca tgactttgaa ttcccccagg aggagtttga tgataaacag      240

ttccagaagg ctcaagccat ctctgtcctc catgagatga tccagcagac cttcaacctc      300

ttcagcacaa aggactcatc tgctgctttg gatgagaccc ttctagatga attctacatc      360

gaacttgacc agcagctgaa tgacctggag tcctgtgtga tgcaggaagt gggggtgata      420

gagtctcccc tgatgtacga ggactccatc ctggctgtga ggaaatactt ccaaagaatc      480

actctatatc tgacagagaa gaaatacagc tcttgtgcct gggaggttgt cagagcagaa      540

atcatgagat ccttctcttt atcaatcaac ttgcaaaaaa gattgaagag taaggaatga      600

gacctggtac aacacggaaa tgattcttat agactaatac agcagctcac acttcgacaa      660

gttgtgctct ttcaaagacc cttgtttctg ccaaaaccat gctatgaatt gaatcaaatg      720

tgtcaagtgt tttcaggagt gttaagcaac atcctgttca gctgtatggg cactagtccc      780

ttacagatga ccatgctgat ggatctattc atctatttat ttaaatcttt atttagttaa      840

ctatctatag ggcttaaatt agttttgttc atattatatt atgtgaactt ttacattgtg      900

aattgtgtaa caaaaacatg ttctttatat ttattatttt gccttgttta ttaaattttt      960

actatagaaa aattctttat ttattcttta aaattgaact ccaaccctga ttgtgcaaac     1020

tgattaaaga atggatggt                                                  1039


<210>  72
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  73
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  73
caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg ccctgtcctt       60

ttctttactt atggccgtgc tggtgctcag ctacaaatcc atctgttctc tgggctgtga      120

tctgcctcag acccacagcc tcggtaatag gagggccttg atactcctgg gacaaatggg      180

aagaatctct cctttctcct gcctgaagga cagacatgat ttccgaatcc cccaggagga      240

gtttgatggc aaccagttcc agaaggctca agccatctct gtcctccatg agatgatcca      300

gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac agagcctcct      360

agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat gtgtgataca      420

ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg ctgtgaggaa      480

atacttccaa agaatcactc tttatctaat agagaggaaa tacagccctt gtgcctggga      540

ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc aaaaaagatt      600

aaggaggaag gattgaaaac tggttcaaca tggcaatgat cctgattgac taatacatta      660

tctcacactt tcatgagttc ttccatttca aagactcact tctataacca cgacgcgttg      720

aatcaaaatt ttcaaatgtt ttcagcagtg taaagaagtg tcgtgtatac ctgtgcaggc      780

actagtcctt tacagatgac cattctgatg tctctgttca tcttttgttt aaatatttat      840

ttaattattt ttaaaattta tgtaatatca tgagtcgctt tacattgtgg ttaatgtaac      900

aatatatgtt cttcatattt agccaatata ttaatttcct ttttcattaa atttttacta      960

tac                                                                    963


<210>  74
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  75
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  75
agagaaccta gagcccaagg ttcagagtca cccatctcag caagcccaga agcatctgca       60

atatctatga tggcctcgcc ctttgcttta ctgatggccc tggtggtgct cagctgcaag      120

tcaagctgct ctctgggctg tgatctccct gagacccaca gcctggataa caggaggacc      180

ttgatgctcc tggcacaaat gagcagaatc tctccttcct cctgtctgat ggacagacat      240

gactttggat ttccccagga ggagtttgat ggcaaccagt tccagaaggc tccagccatc      300

tctgtcctcc atgagctgat ccagcagatc ttcaacctct ttaccacaaa agattcatct      360

gctgcttggg atgaggacct cctagacaaa ttctgcaccg aactctacca gcagctgaat      420

gacttggaag cctgtgtgat gcaggaggag agggtgggag aaactcccct gatgaatgcg      480

gactccatct tggctgtgaa gaaatacttc cgaagaatca ctctctatct gacagagaag      540

aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc cctctcttta      600

tcaacaaact tgcaagaaag attaaggagg aaggaataac acctggtcca acatgaaaca      660

attcttattg actcatatac caggtcacgc tttcatgaat tctgc                      705


<210>  76
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  77
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  77
gttacccctc atcaaccagc ccagcagcat cttcgggatt cccaatggca ttgccctttg       60

ctttaatgat ggccctggtg gtgctcagct gcaagtcaag ctgctctctg ggctgtaatc      120

tgtctcaaac ccacagcctg aataacagga ggactttgat gctcatggca caaatgagga      180

gaatctctcc tttctcctgc ctgaaggaca gacatgactt tgaatttccc caggaggaat      240

ttgatggcaa ccagttccag aaagctcaag ccatctctgt cctccatgag atgatgcagc      300

agaccttcaa tctcttcagc acaaagaact catctgctgc ttgggatgag accctcctag      360

aaaaattcta cattgaactt ttccagcaaa tgaatgacct ggaagcctgt gtgatacagg      420

aggttggggt ggaagagact cccctgatga atgaggactc catcctggct gtgaagaaat      480

acttccaaag aatcactctt tatctgatgg agaagaaata cagcccttgt gcctgggagg      540

ttgtcagagc agaaatcatg agatccctct ctttttcaac aaacttgcaa aaaagattaa      600

ggaggaagga ttgaaaactg gttcatcatg gaaatgattc tcattgacta atacatcatc      660

tcacactttc atgagttctt ccatttcaaa gactcacttc tcctataacc accacaagtt      720

gaatcaaaat tttcaaatgt tttcaggagt gtaaagaagc atcatgtata cctgtgca        778


<210>  78
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  79
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  79
atcccaatgg ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc       60

atctgttctc tgggctgtga tctgcctcag actcacagcc tgggtaatag gagggccttg      120

atactcctgg cacaaatggg aagaatctct catttctcct gcctgaagga cagatatgat      180

ttcggattcc cccaggaggt gtttgatggc aaccagttcc agaaggctca agccatctct      240

gccttccatg agatgatcca gcagaccttc aatctcttca gcacaaagga ttcatctgct      300

gcttgggatg agaccctcct agacaaattc tacattgaac ttttccagca actgaatgac      360

ctagaagcct gtgtgacaca ggaggttggg gtggaagaga ttgccctgat gaatgaggac      420

tccatcctgg ctgtgaggaa atactttcaa agaatcactc tttatctgat ggggaagaaa      480

tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcctt ctctttttca      540

acaaacttgc aaaaaggatt aagaaggaag gattgaaaac tcattcaaca tggaaatgat      600

cctcattgat taatacatca tctcacactt tcatgagttc ttccatttca aagactcact      660

tctataacca ccacaagttg aatcaaaatt tcaaaatgtt ttcaggagtg taaagaagca      720

tcgtgtttac ctgtgcaggc actagtcctt tacagatgac catgctgatg tctctattca      780

tctatttatt taaatattta tttatttaac tatttttaag gtttaaatca tgttttatgt      840

aatatcatgt gtacctttac attttgctta atgtaacaat atatgttctt catatttagt      900

taatatatta acttcctttt cattaaattt ttactatac                             939


<210>  80
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  81
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  81
gttcaaggtt acccatctca agtagcctag caacatttgc aacatcccaa tggccctgtc       60

cttttcttta ctgatggccg tgctggtgct cagctacaaa tccatctgtt ctctaggctg      120

tgatctgcct cagacccaca gcctgggtaa taggagggcc ttgatactcc tggcacaaat      180

gggaagaatc tctcctttct cctgcctgaa ggacagacat gactttggac ttccccagga      240

ggagtttgat ggcaaccagt tccagaagac tcaagccatc tctgtcctcc atgagatgat      300

ccagcagacc ttcaatctct tcagcacaga ggactcatct gctgcttggg aacagagcct      360

cctagaaaaa ttttccactg aactttacca gcaactgaat aacctggaag catgtgtgat      420

acaggaggtt gggatggaag agactcccct gatgaatgag gactccatcc tggctgtgag      480

gaaatacttc caaagaatca ctctttatct aacagagaag aaatacagcc cttgtgcctg      540

ggaggttgtc agagcagaaa tcatgagatc tctctctttt tcaacaaact tgcaaaaaat      600

attaaggagg aaggattgaa aactggttca acatggcaat gatcctgatt gactaataca      660

ttatctcaca ctttcatgag ttcctccatt tcaaagactc acttctataa ccaccacgag      720

ttgaatcaaa attttcaaat gttttcagca gtgtaaagaa gcgtcgtgta tacctgtgca      780

ggcactagta ctttacagat gaccatgctg atgtctctgt tcatctattt atttaaatat      840

ttatttaatt atttttaaga tttaaattat ttttttatgt aatatcatgt gtacctttac      900

attgtggtga atgtaacaat atatgttctt catatttagc caatatatta atttcctttt      960

tcattaaatt tttactatac                                                  980


<210>  82
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  83
<211>  1024
<212>  DNA
<213>  Homo sapiens

<400>  83
ttcaaggtta cccatctcaa gtagcctagc aatattggca acatcccaat ggccctgtcc       60

ttttctttac tgatggccgt gctggtgctc agctacaaat ccatctgttc tctgggctgt      120

gatctgcctc agacccacag cctgggtaat aggagggcct tgatactcct ggcacaaatg      180

ggaagaatct ctcctttctc ctgcctgaag gacagacatg actttggatt cccccaggag      240

gagtttgatg gcaaccagtt ccagaaggct caagccatct ctgtcctcca tgagatgatc      300

cagcagacct tcaatctctt cagcacaaag gactcatctg ctacttggga acagagcctc      360

ctagaaaaat tttccactga acttaaccag cagctgaatg acctggaagc ctgcgtgata      420

caggaggttg gggtggaaga gactcccctg atgaatgtgg actccatcct ggctgtgaag      480

aaatacttcc aaagaatcac tctttatctg acagagaaga aatacagccc ttgtgcctgg      540

gaggttgtca gagcagaaat catgagatcc ttctctttat caaaaatttt tcaagaaaga      600

ttaaggagga aggaatgaaa cctgtttcaa catggaaatg atctgtattg actaatacac      660

cagtccacac ttctatgact tctgccattt caaagactca tttctcctat aaccaccgca      720

tgagttgaat caaaattttc agatcttttc aggagtgtaa ggaaacatca tgtttacctg      780

tgcaggcact agtcctttac agatgaccat gctgatagat ctaattatct atctattgaa      840

atatttattt atttattaga tttaaattat ttttgtccat gtaatattat gtgtactttt      900

acattgtgtt atatcaaaat atgttattta tatttagtca atatattatt ttctttttat      960

taatttttac tattaaaact tcttatatta tttgtttatt ctttaataaa gaaataccaa     1020

gccc                                                                  1024


<210>  84
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  85
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  85
acattctaac tgcaaccttt cgaagccttt gctctggcac aacaggtagt aggcgacact       60

gttcgtgttg tcaacatgac caacaagtgt ctcctccaaa ttgctctcct gttgtgcttc      120

tccactacag ctctttccat gagctacaac ttgcttggat tcctacaaag aagcagcaat      180

tttcagtgtc agaagctcct gtggcaattg aatgggaggc ttgaatactg cctcaaggac      240

aggatgaact ttgacatccc tgaggagatt aagcagctgc agcagttcca gaaggaggac      300

gccgcattga ccatctatga gatgctccag aacatctttg ctattttcag acaagattca      360

tctagcactg gctggaatga gactattgtt gagaacctcc tggctaatgt ctatcatcag      420

ataaaccatc tgaagacagt cctggaagaa aaactggaga aagaagattt caccagggga      480

aaactcatga gcagtctgca cctgaaaaga tattatggga ggattctgca ttacctgaag      540

gccaaggagt acagtcactg tgcctggacc atagtcagag tggaaatcct aaggaacttt      600

tacttcatta acagacttac aggttacctc cgaaactgaa gatctcctag cctgtgcctc      660

tgggactgga caattgcttc aagcattctt caaccagcag atgctgttta agtgactgat      720

ggctaatgta ctgcatatga aaggacacta gaagattttg aaatttttat taaattatga      780

gttattttta tttatttaaa ttttattttg gaaaataaat tatttttggt gcaaaagtca      840


<210>  86
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  87
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  87
gatctggtaa acctgaagca aatatagaaa cctatagggc ctgacttcct acataaagta       60

aggagggtaa aaatggaggc tagaataagg gttaaaattt tgcttctaga acagagaaaa      120

tgattttttt catatatata tgaatatata ttatatatac acatatatac atatattcac      180

tatagtgtgt atacataaat atataatata tatattgtta gtgtagtgtg tgtctgatta      240

tttacatgca tatagtatat acacttatga ctttagtacc cagacgtttt tcatttgatt      300

aagcattcat ttgtattgac acagctgaag tttactggag tttagctgaa gtctaatgca      360

aaattaatag attgttgtca tcctcttaag gtcataggga gaacacacaa atgaaaacag      420

taaaagaaac tgaaagtaca gagaaatgtt cagaaaatga aaaccatgtg tttcctatta      480

aaagccatgc atacaagcaa tgtcttcaga aaacctaggg tccaaggtta agccatatcc      540

cagctcagta aagccaggag catcctcatt tcccaatggc cctcctgttc cctctactgg      600

cagccctagt gatgaccagc tatagccctg ttggatctct gggctgtgat ctgcctcaga      660

accatggcct acttagcagg aacaccttgg tgcttctgca ccaaatgagg agaatctccc      720

ctttcttgtg tctcaaggac agaagagact tcaggttccc ccaggagatg gtaaaaggga      780

gccagttgca gaaggcccat gtcatgtctg tcctccatga gatgctgcag cagatcttca      840

gcctcttcca cacagagcgc tcctctgctg cctggaacat gaccctccta gaccaactcc      900

acactggact tcatcagcaa ctgcaacacc tggagacctg cttgctgcag gtagtgggag      960

aaggagaatc tgctggggca attagcagcc ctgcactgac cttgaggagg tacttccagg     1020

gaatccgtgt ctacctgaaa gagaagaaat acagcgactg tgcctgggaa gttgtcagaa     1080

tggaaatcat gaaatccttg ttcttatcaa caaacatgca agaaagactg agaagtaaag     1140

atagagacct gggctcatct tgaaatgatt ctcattgatt aatttgccat ataacacttg     1200

cacatgtgac tctggtcaat tcaaaagact cttatttcgg ctttaatcac agaattgact     1260

gaattagttc tgcaaatact ttgtcggtat attaagccag tatatgttaa aaagacttag     1320

gttcaggggc atcagtccct aagatgttat ttatttttac tcatttattt attcttacat     1380

tttatcatat ttatactatt tatattctta tataacaaat gtttgccttt acattgtatt     1440

aagataacaa aacatgttca gctttccatt tggttaaata ttgtattttg ttatttatta     1500

aattattttc aaac                                                       1514


<210>  88
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  89
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  89
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210>  90
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  91
<211>  3814
<212>  DNA
<213>  Homo sapiens

<400>  91
atttccgggg acgccgcgcc ggactgaggc tgtgcgcccg agactccggg tccccagggg       60

ctgcgccggg ccggcctggc aagggggacg agtcagtgga cactccagga agagcggccc      120

cgcggggggc gatgaccgtg cgctgaccct gactcactcc aggtccggag gcgggggccc      180

ccggggcgac tcgggggcgg accgcggggc ggagctgccg cccgtgagtc cggccgagcc      240

acctgagccc gagccgcggg acaccgtcgc tcctgctctc cgaatgctgc gcaccgcgat      300

gggcctgagg agctggctcg ccgccccatg gggcgcgctg ccgcctcggc caccgctgct      360

gctgctcctg ctgctgctgc tcctgctgca gccgccgcct ccgacctggg cgctcagccc      420

ccggatcagc ctgcctctgg gctctgaaga gcggccattc ctcagattcg aagctgaaca      480

catctccaac tacacagccc ttctgctgag cagggatggc aggaccctgt acgtgggtgc      540

tcgagaggcc ctctttgcac tcagtagcaa cctcagcttc ctgccaggcg gggagtacca      600

ggagctgctt tggggtgcag acgcagagaa gaaacagcag tgcagcttca agggcaagga      660

cccacagcgc gactgtcaaa actacatcaa gatcctcctg ccgctcagcg gcagtcacct      720

gttcacctgt ggcacagcag ccttcagccc catgtgtacc tacatcaaca tggagaactt      780

caccctggca agggacgaga aggggaatgt cctcctggaa gatggcaagg gccgttgtcc      840

cttcgacccg aatttcaagt ccactgccct ggtggttgat ggcgagctct acactggaac      900

agtcagcagc ttccaaggga atgacccggc catctcgcgg agccaaagcc ttcgccccac      960

caagaccgag agctccctca actggctgca agacccagct tttgtggcct cagcctacat     1020

tcctgagagc ctgggcagct tgcaaggcga tgatgacaag atctactttt tcttcagcga     1080

gactggccag gaatttgagt tctttgagaa caccattgtg tcccgcattg cccgcatctg     1140

caagggcgat gagggtggag agcgggtgct acagcagcgc tggacctcct tcctcaaggc     1200

ccagctgctg tgctcacggc ccgacgatgg cttccccttc aacgtgctgc aggatgtctt     1260

cacgctgagc cccagccccc aggactggcg tgacaccctt ttctatgggg tcttcacttc     1320

ccagtggcac aggggaacta cagaaggctc tgccgtctgt gtcttcacaa tgaaggatgt     1380

gcagagagtc ttcagcggcc tctacaagga ggtgaaccgt gagacacagc agtggtacac     1440

cgtgacccac ccggtgccca caccccggcc tggagcgtgc atcaccaaca gtgcccggga     1500

aaggaagatc aactcatccc tgcagctccc agaccgcgtg ctgaacttcc tcaaggacca     1560

cttcctgatg gacgggcagg tccgaagccg catgctgctg ctgcagcccc aggctcgcta     1620

ccagcgcgtg gctgtacacc gcgtccctgg cctgcaccac acctacgatg tcctcttcct     1680

gggcactggt gacggccggc tccacaaggc agtgagcgtg ggcccccggg tgcacatcat     1740

tgaggagctg cagatcttct catcgggaca gcccgtgcag aatctgctcc tggacaccca     1800

cagggggctg ctgtatgcgg cctcacactc gggcgtagtc caggtgccca tggccaactg     1860

cagcctgtac aggagctgtg gggactgcct cctcgcccgg gacccctact gtgcttggag     1920

cggctccagc tgcaagcacg tcagcctcta ccagcctcag ctggccacca ggccgtggat     1980

ccaggacatc gagggagcca gcgccaagga cctttgcagc gcgtcttcgg ttgtgtcccc     2040

gtcttttgta ccaacagggg agaagccatg tgagcaagtc cagttccagc ccaacacagt     2100

gaacactttg gcctgcccgc tcctctccaa cctggcgacc cgactctggc tacgcaacgg     2160

ggcccccgtc aatgcctcgg cctcctgcca cgtgctaccc actggggacc tgctgctggt     2220

gggcacccaa cagctggggg agttccagtg ctggtcacta gaggagggct tccagcagct     2280

ggtagccagc tactgcccag aggtggtgga ggacggggtg gcagaccaaa cagatgaggg     2340

tggcagtgta cccgtcatta tcagcacatc gcgtgtgagt gcaccagctg gtggcaaggc     2400

cagctggggt gcagacaggt cctactggaa ggagttcctg gtgatgtgca cgctctttgt     2460

gctggccgtg ctgctcccag ttttattctt gctctaccgg caccggaaca gcatgaaagt     2520

cttcctgaag cagggggaat gtgccagcgt gcaccccaag acctgccctg tggtgctgcc     2580

ccctgagacc cgcccactca acggcctagg gccccctagc accccgctcg atcaccgagg     2640

gtaccagtcc ctgtcagaca gccccccggg gtcccgagtc ttcactgagt cagagaagag     2700

gccactcagc atccaagaca gcttcgtgga ggtatcccca gtgtgccccc ggccccgggt     2760

ccgccttggc tcggagatcc gtgactctgt ggtgtgagag ctgacttcca gaggacgctg     2820

ccctggcttc aggggctgtg aatgctcgga gagggtcaac tggacctccc ctccgctctg     2880

ctcttcgtgg aacacgaccg tggtgcccgg cccttgggag ccttggggcc agctggcctg     2940

ctgctctcca gtcaagtagc gaagctccta ccacccagac acccaaacag ccgtggcccc     3000

agaggtcctg gccaaatatg ggggcctgcc taggttggtg gaacagtgct ccttatgtaa     3060

actgagccct ttgtttaaaa aacaattcca aatgtgaaac tagaatgaga gggaagagat     3120

agcatggcat gcagcacaca cggctgctcc agttcatggc ctcccagggg tgctggggat     3180

gcatccaaag tggttgtctg agacagagtt ggaaaccctc accaactggc ctcttcacct     3240

tccacattat cccgctgcca ccggctgccc tgtctcactg cagattcagg accagcttgg     3300

gctgcgtgcg ttctgccttg ccagtcagcc gaggatgtag ttgttgctgc cgtcgtccca     3360

ccacctcagg gaccagaggg ctaggttggc actgcggccc tcaccaggtc ctgggctcgg     3420

acccaactcc tggacctttc cagcctgtat caggctgtgg ccacacgaga ggacagcgcg     3480

agctcaggag agatttcgtg acaatgtacg cctttccctc agaattcagg gaagagactg     3540

tcgcctgcct tcctccgttg ttgcgtgaga acccgtgtgc cccttcccac catatccacc     3600

ctcgctccat ctttgaactc aaacacgagg aactaactgc accctggtcc tctccccagt     3660

ccccagttca ccctccatcc ctcaccttcc tccactctaa gggatatcaa cactgcccag     3720

cacaggggcc ctgaatttat gtggttttta tacatttttt aataagatgc actttatgtc     3780

attttttaat aaagtctgaa gaattactgt ttaa                                 3814


<210>  92
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Leu Arg Thr Ala Met Gly Leu Arg Ser Trp Leu Ala Ala Pro Trp 
1               5                   10                  15      


Gly Ala Leu Pro Pro Arg Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gln Pro Pro Pro Pro Thr Trp Ala Leu Ser Pro Arg Ile 
        35                  40                  45              


Ser Leu Pro Leu Gly Ser Glu Glu Arg Pro Phe Leu Arg Phe Glu Ala 
    50                  55                  60                  


Glu His Ile Ser Asn Tyr Thr Ala Leu Leu Leu Ser Arg Asp Gly Arg 
65                  70                  75                  80  


Thr Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Leu Ser Ser Asn 
                85                  90                  95      


Leu Ser Phe Leu Pro Gly Gly Glu Tyr Gln Glu Leu Leu Trp Gly Ala 
            100                 105                 110         


Asp Ala Glu Lys Lys Gln Gln Cys Ser Phe Lys Gly Lys Asp Pro Gln 
        115                 120                 125             


Arg Asp Cys Gln Asn Tyr Ile Lys Ile Leu Leu Pro Leu Ser Gly Ser 
    130                 135                 140                 


His Leu Phe Thr Cys Gly Thr Ala Ala Phe Ser Pro Met Cys Thr Tyr 
145                 150                 155                 160 


Ile Asn Met Glu Asn Phe Thr Leu Ala Arg Asp Glu Lys Gly Asn Val 
                165                 170                 175     


Leu Leu Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro Asn Phe Lys 
            180                 185                 190         


Ser Thr Ala Leu Val Val Asp Gly Glu Leu Tyr Thr Gly Thr Val Ser 
        195                 200                 205             


Ser Phe Gln Gly Asn Asp Pro Ala Ile Ser Arg Ser Gln Ser Leu Arg 
    210                 215                 220                 


Pro Thr Lys Thr Glu Ser Ser Leu Asn Trp Leu Gln Asp Pro Ala Phe 
225                 230                 235                 240 


Val Ala Ser Ala Tyr Ile Pro Glu Ser Leu Gly Ser Leu Gln Gly Asp 
                245                 250                 255     


Asp Asp Lys Ile Tyr Phe Phe Phe Ser Glu Thr Gly Gln Glu Phe Glu 
            260                 265                 270         


Phe Phe Glu Asn Thr Ile Val Ser Arg Ile Ala Arg Ile Cys Lys Gly 
        275                 280                 285             


Asp Glu Gly Gly Glu Arg Val Leu Gln Gln Arg Trp Thr Ser Phe Leu 
    290                 295                 300                 


Lys Ala Gln Leu Leu Cys Ser Arg Pro Asp Asp Gly Phe Pro Phe Asn 
305                 310                 315                 320 


Val Leu Gln Asp Val Phe Thr Leu Ser Pro Ser Pro Gln Asp Trp Arg 
                325                 330                 335     


Asp Thr Leu Phe Tyr Gly Val Phe Thr Ser Gln Trp His Arg Gly Thr 
            340                 345                 350         


Thr Glu Gly Ser Ala Val Cys Val Phe Thr Met Lys Asp Val Gln Arg 
        355                 360                 365             


Val Phe Ser Gly Leu Tyr Lys Glu Val Asn Arg Glu Thr Gln Gln Trp 
    370                 375                 380                 


Tyr Thr Val Thr His Pro Val Pro Thr Pro Arg Pro Gly Ala Cys Ile 
385                 390                 395                 400 


Thr Asn Ser Ala Arg Glu Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro 
                405                 410                 415     


Asp Arg Val Leu Asn Phe Leu Lys Asp His Phe Leu Met Asp Gly Gln 
            420                 425                 430         


Val Arg Ser Arg Met Leu Leu Leu Gln Pro Gln Ala Arg Tyr Gln Arg 
        435                 440                 445             


Val Ala Val His Arg Val Pro Gly Leu His His Thr Tyr Asp Val Leu 
    450                 455                 460                 


Phe Leu Gly Thr Gly Asp Gly Arg Leu His Lys Ala Val Ser Val Gly 
465                 470                 475                 480 


Pro Arg Val His Ile Ile Glu Glu Leu Gln Ile Phe Ser Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Asn Leu Leu Leu Asp Thr His Arg Gly Leu Leu Tyr Ala 
            500                 505                 510         


Ala Ser His Ser Gly Val Val Gln Val Pro Met Ala Asn Cys Ser Leu 
        515                 520                 525             


Tyr Arg Ser Cys Gly Asp Cys Leu Leu Ala Arg Asp Pro Tyr Cys Ala 
    530                 535                 540                 


Trp Ser Gly Ser Ser Cys Lys His Val Ser Leu Tyr Gln Pro Gln Leu 
545                 550                 555                 560 


Ala Thr Arg Pro Trp Ile Gln Asp Ile Glu Gly Ala Ser Ala Lys Asp 
                565                 570                 575     


Leu Cys Ser Ala Ser Ser Val Val Ser Pro Ser Phe Val Pro Thr Gly 
            580                 585                 590         


Glu Lys Pro Cys Glu Gln Val Gln Phe Gln Pro Asn Thr Val Asn Thr 
        595                 600                 605             


Leu Ala Cys Pro Leu Leu Ser Asn Leu Ala Thr Arg Leu Trp Leu Arg 
    610                 615                 620                 


Asn Gly Ala Pro Val Asn Ala Ser Ala Ser Cys His Val Leu Pro Thr 
625                 630                 635                 640 


Gly Asp Leu Leu Leu Val Gly Thr Gln Gln Leu Gly Glu Phe Gln Cys 
                645                 650                 655     


Trp Ser Leu Glu Glu Gly Phe Gln Gln Leu Val Ala Ser Tyr Cys Pro 
            660                 665                 670         


Glu Val Val Glu Asp Gly Val Ala Asp Gln Thr Asp Glu Gly Gly Ser 
        675                 680                 685             


Val Pro Val Ile Ile Ser Thr Ser Arg Val Ser Ala Pro Ala Gly Gly 
    690                 695                 700                 


Lys Ala Ser Trp Gly Ala Asp Arg Ser Tyr Trp Lys Glu Phe Leu Val 
705                 710                 715                 720 


Met Cys Thr Leu Phe Val Leu Ala Val Leu Leu Pro Val Leu Phe Leu 
                725                 730                 735     


Leu Tyr Arg His Arg Asn Ser Met Lys Val Phe Leu Lys Gln Gly Glu 
            740                 745                 750         


Cys Ala Ser Val His Pro Lys Thr Cys Pro Val Val Leu Pro Pro Glu 
        755                 760                 765             


Thr Arg Pro Leu Asn Gly Leu Gly Pro Pro Ser Thr Pro Leu Asp His 
    770                 775                 780                 


Arg Gly Tyr Gln Ser Leu Ser Asp Ser Pro Pro Gly Ser Arg Val Phe 
785                 790                 795                 800 


Thr Glu Ser Glu Lys Arg Pro Leu Ser Ile Gln Asp Ser Phe Val Glu 
                805                 810                 815     


Val Ser Pro Val Cys Pro Arg Pro Arg Val Arg Leu Gly Ser Glu Ile 
            820                 825                 830         


Arg Asp Ser Val Val 
        835         


<210>  93
<211>  3780
<212>  DNA
<213>  Homo sapiens

<400>  93
gcttgcgggt gagctctgcc caagccgagg ctgcggggcc ggcgccggcg ggaggactgc       60

ggtgccccgc ggaggggctg agtttgccag ggcccacttg accctgtttc ccacctcccg      120

ccccccaggt ccggaggcgg gggcccccgg ggcgactcgg gggcggaccg cggggcggag      180

ctgccgcccg tgagtccggc cgagccacct gagcccgagc cgcgggacac cgtcgctcct      240

gctctccgaa tgctgcgcac cgcgatgggc ctgaggagct ggctcgccgc cccatggggc      300

gcgctgccgc ctcggccacc gctgctgctg ctcctgctgc tgctgctcct gctgcagccg      360

ccgcctccga cctgggcgct cagcccccgg atcagcctgc ctctgggctc tgaagagcgg      420

ccattcctca gattcgaagc tgaacacatc tccaactaca cagcccttct gctgagcagg      480

gatggcagga ccctgtacgt gggtgctcga gaggccctct ttgcactcag tagcaacctc      540

agcttcctgc caggcgggga gtaccaggag ctgctttggg gtgcagacgc agagaagaaa      600

cagcagtgca gcttcaaggg caaggaccca cagcgcgact gtcaaaacta catcaagatc      660

ctcctgccgc tcagcggcag tcacctgttc acctgtggca cagcagcctt cagccccatg      720

tgtacctaca tcaacatgga gaacttcacc ctggcaaggg acgagaaggg gaatgtcctc      780

ctggaagatg gcaagggccg ttgtcccttc gacccgaatt tcaagtccac tgccctggtg      840

gttgatggcg agctctacac tggaacagtc agcagcttcc aagggaatga cccggccatc      900

tcgcggagcc aaagccttcg ccccaccaag accgagagct ccctcaactg gctgcaagac      960

ccagcttttg tggcctcagc ctacattcct gagagcctgg gcagcttgca aggcgatgat     1020

gacaagatct actttttctt cagcgagact ggccaggaat ttgagttctt tgagaacacc     1080

attgtgtccc gcattgcccg catctgcaag ggcgatgagg gtggagagcg ggtgctacag     1140

cagcgctgga cctccttcct caaggcccag ctgctgtgct cacggcccga cgatggcttc     1200

cccttcaacg tgctgcagga tgtcttcacg ctgagcccca gcccccagga ctggcgtgac     1260

acccttttct atggggtctt cacttcccag tggcacaggg gaactacaga aggctctgcc     1320

gtctgtgtct tcacaatgaa ggatgtgcag agagtcttca gcggcctcta caaggaggtg     1380

aaccgtgaga cacagcagtg gtacaccgtg acccacccgg tgcccacacc ccggcctgga     1440

gcgtgcatca ccaacagtgc ccgggaaagg aagatcaact catccctgca gctcccagac     1500

cgcgtgctga acttcctcaa ggaccacttc ctgatggacg ggcaggtccg aagccgcatg     1560

ctgctgctgc agccccaggc tcgctaccag cgcgtggctg tacaccgcgt ccctggcctg     1620

caccacacct acgatgtcct cttcctgggc actggtgacg gccggctcca caaggcagtg     1680

agcgtgggcc cccgggtgca catcattgag gagctgcaga tcttctcatc gggacagccc     1740

gtgcagaatc tgctcctgga cacccacagg gggctgctgt atgcggcctc acactcgggc     1800

gtagtccagg tgcccatggc caactgcagc ctgtacagga gctgtgggga ctgcctcctc     1860

gcccgggacc cctactgtgc ttggagcggc tccagctgca agcacgtcag cctctaccag     1920

cctcagctgg ccaccaggcc gtggatccag gacatcgagg gagccagcgc caaggacctt     1980

tgcagcgcgt cttcggttgt gtccccgtct tttgtaccaa caggggagaa gccatgtgag     2040

caagtccagt tccagcccaa cacagtgaac actttggcct gcccgctcct ctccaacctg     2100

gcgacccgac tctggctacg caacggggcc cccgtcaatg cctcggcctc ctgccacgtg     2160

ctacccactg gggacctgct gctggtgggc acccaacagc tgggggagtt ccagtgctgg     2220

tcactagagg agggcttcca gcagctggta gccagctact gcccagaggt ggtggaggac     2280

ggggtggcag accaaacaga tgagggtggc agtgtacccg tcattatcag cacatcgcgt     2340

gtgagtgcac cagctggtgg caaggccagc tggggtgcag acaggtccta ctggaaggag     2400

ttcctggtga tgtgcacgct ctttgtgctg gccgtgctgc tcccagtttt attcttgctc     2460

taccggcacc ggaacagcat gaaagtcttc ctgaagcagg gggaatgtgc cagcgtgcac     2520

cccaagacct gccctgtggt gctgccccct gagacccgcc cactcaacgg cctagggccc     2580

cctagcaccc cgctcgatca ccgagggtac cagtccctgt cagacagccc cccggggtcc     2640

cgagtcttca ctgagtcaga gaagaggcca ctcagcatcc aagacagctt cgtggaggta     2700

tccccagtgt gcccccggcc ccgggtccgc cttggctcgg agatccgtga ctctgtggtg     2760

tgagagctga cttccagagg acgctgccct ggcttcaggg gctgtgaatg ctcggagagg     2820

gtcaactgga cctcccctcc gctctgctct tcgtggaaca cgaccgtggt gcccggccct     2880

tgggagcctt ggggccagct ggcctgctgc tctccagtca agtagcgaag ctcctaccac     2940

ccagacaccc aaacagccgt ggccccagag gtcctggcca aatatggggg cctgcctagg     3000

ttggtggaac agtgctcctt atgtaaactg agccctttgt ttaaaaaaca attccaaatg     3060

tgaaactaga atgagaggga agagatagca tggcatgcag cacacacggc tgctccagtt     3120

catggcctcc caggggtgct ggggatgcat ccaaagtggt tgtctgagac agagttggaa     3180

accctcacca actggcctct tcaccttcca cattatcccg ctgccaccgg ctgccctgtc     3240

tcactgcaga ttcaggacca gcttgggctg cgtgcgttct gccttgccag tcagccgagg     3300

atgtagttgt tgctgccgtc gtcccaccac ctcagggacc agagggctag gttggcactg     3360

cggccctcac caggtcctgg gctcggaccc aactcctgga cctttccagc ctgtatcagg     3420

ctgtggccac acgagaggac agcgcgagct caggagagat ttcgtgacaa tgtacgcctt     3480

tccctcagaa ttcagggaag agactgtcgc ctgccttcct ccgttgttgc gtgagaaccc     3540

gtgtgcccct tcccaccata tccaccctcg ctccatcttt gaactcaaac acgaggaact     3600

aactgcaccc tggtcctctc cccagtcccc agttcaccct ccatccctca ccttcctcca     3660

ctctaaggga tatcaacact gcccagcaca ggggccctga atttatgtgg tttttataca     3720

ttttttaata agatgcactt tatgtcattt tttaataaag tctgaagaat tactgtttaa     3780


<210>  94
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Leu Arg Thr Ala Met Gly Leu Arg Ser Trp Leu Ala Ala Pro Trp 
1               5                   10                  15      


Gly Ala Leu Pro Pro Arg Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gln Pro Pro Pro Pro Thr Trp Ala Leu Ser Pro Arg Ile 
        35                  40                  45              


Ser Leu Pro Leu Gly Ser Glu Glu Arg Pro Phe Leu Arg Phe Glu Ala 
    50                  55                  60                  


Glu His Ile Ser Asn Tyr Thr Ala Leu Leu Leu Ser Arg Asp Gly Arg 
65                  70                  75                  80  


Thr Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Leu Ser Ser Asn 
                85                  90                  95      


Leu Ser Phe Leu Pro Gly Gly Glu Tyr Gln Glu Leu Leu Trp Gly Ala 
            100                 105                 110         


Asp Ala Glu Lys Lys Gln Gln Cys Ser Phe Lys Gly Lys Asp Pro Gln 
        115                 120                 125             


Arg Asp Cys Gln Asn Tyr Ile Lys Ile Leu Leu Pro Leu Ser Gly Ser 
    130                 135                 140                 


His Leu Phe Thr Cys Gly Thr Ala Ala Phe Ser Pro Met Cys Thr Tyr 
145                 150                 155                 160 


Ile Asn Met Glu Asn Phe Thr Leu Ala Arg Asp Glu Lys Gly Asn Val 
                165                 170                 175     


Leu Leu Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro Asn Phe Lys 
            180                 185                 190         


Ser Thr Ala Leu Val Val Asp Gly Glu Leu Tyr Thr Gly Thr Val Ser 
        195                 200                 205             


Ser Phe Gln Gly Asn Asp Pro Ala Ile Ser Arg Ser Gln Ser Leu Arg 
    210                 215                 220                 


Pro Thr Lys Thr Glu Ser Ser Leu Asn Trp Leu Gln Asp Pro Ala Phe 
225                 230                 235                 240 


Val Ala Ser Ala Tyr Ile Pro Glu Ser Leu Gly Ser Leu Gln Gly Asp 
                245                 250                 255     


Asp Asp Lys Ile Tyr Phe Phe Phe Ser Glu Thr Gly Gln Glu Phe Glu 
            260                 265                 270         


Phe Phe Glu Asn Thr Ile Val Ser Arg Ile Ala Arg Ile Cys Lys Gly 
        275                 280                 285             


Asp Glu Gly Gly Glu Arg Val Leu Gln Gln Arg Trp Thr Ser Phe Leu 
    290                 295                 300                 


Lys Ala Gln Leu Leu Cys Ser Arg Pro Asp Asp Gly Phe Pro Phe Asn 
305                 310                 315                 320 


Val Leu Gln Asp Val Phe Thr Leu Ser Pro Ser Pro Gln Asp Trp Arg 
                325                 330                 335     


Asp Thr Leu Phe Tyr Gly Val Phe Thr Ser Gln Trp His Arg Gly Thr 
            340                 345                 350         


Thr Glu Gly Ser Ala Val Cys Val Phe Thr Met Lys Asp Val Gln Arg 
        355                 360                 365             


Val Phe Ser Gly Leu Tyr Lys Glu Val Asn Arg Glu Thr Gln Gln Trp 
    370                 375                 380                 


Tyr Thr Val Thr His Pro Val Pro Thr Pro Arg Pro Gly Ala Cys Ile 
385                 390                 395                 400 


Thr Asn Ser Ala Arg Glu Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro 
                405                 410                 415     


Asp Arg Val Leu Asn Phe Leu Lys Asp His Phe Leu Met Asp Gly Gln 
            420                 425                 430         


Val Arg Ser Arg Met Leu Leu Leu Gln Pro Gln Ala Arg Tyr Gln Arg 
        435                 440                 445             


Val Ala Val His Arg Val Pro Gly Leu His His Thr Tyr Asp Val Leu 
    450                 455                 460                 


Phe Leu Gly Thr Gly Asp Gly Arg Leu His Lys Ala Val Ser Val Gly 
465                 470                 475                 480 


Pro Arg Val His Ile Ile Glu Glu Leu Gln Ile Phe Ser Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Asn Leu Leu Leu Asp Thr His Arg Gly Leu Leu Tyr Ala 
            500                 505                 510         


Ala Ser His Ser Gly Val Val Gln Val Pro Met Ala Asn Cys Ser Leu 
        515                 520                 525             


Tyr Arg Ser Cys Gly Asp Cys Leu Leu Ala Arg Asp Pro Tyr Cys Ala 
    530                 535                 540                 


Trp Ser Gly Ser Ser Cys Lys His Val Ser Leu Tyr Gln Pro Gln Leu 
545                 550                 555                 560 


Ala Thr Arg Pro Trp Ile Gln Asp Ile Glu Gly Ala Ser Ala Lys Asp 
                565                 570                 575     


Leu Cys Ser Ala Ser Ser Val Val Ser Pro Ser Phe Val Pro Thr Gly 
            580                 585                 590         


Glu Lys Pro Cys Glu Gln Val Gln Phe Gln Pro Asn Thr Val Asn Thr 
        595                 600                 605             


Leu Ala Cys Pro Leu Leu Ser Asn Leu Ala Thr Arg Leu Trp Leu Arg 
    610                 615                 620                 


Asn Gly Ala Pro Val Asn Ala Ser Ala Ser Cys His Val Leu Pro Thr 
625                 630                 635                 640 


Gly Asp Leu Leu Leu Val Gly Thr Gln Gln Leu Gly Glu Phe Gln Cys 
                645                 650                 655     


Trp Ser Leu Glu Glu Gly Phe Gln Gln Leu Val Ala Ser Tyr Cys Pro 
            660                 665                 670         


Glu Val Val Glu Asp Gly Val Ala Asp Gln Thr Asp Glu Gly Gly Ser 
        675                 680                 685             


Val Pro Val Ile Ile Ser Thr Ser Arg Val Ser Ala Pro Ala Gly Gly 
    690                 695                 700                 


Lys Ala Ser Trp Gly Ala Asp Arg Ser Tyr Trp Lys Glu Phe Leu Val 
705                 710                 715                 720 


Met Cys Thr Leu Phe Val Leu Ala Val Leu Leu Pro Val Leu Phe Leu 
                725                 730                 735     


Leu Tyr Arg His Arg Asn Ser Met Lys Val Phe Leu Lys Gln Gly Glu 
            740                 745                 750         


Cys Ala Ser Val His Pro Lys Thr Cys Pro Val Val Leu Pro Pro Glu 
        755                 760                 765             


Thr Arg Pro Leu Asn Gly Leu Gly Pro Pro Ser Thr Pro Leu Asp His 
    770                 775                 780                 


Arg Gly Tyr Gln Ser Leu Ser Asp Ser Pro Pro Gly Ser Arg Val Phe 
785                 790                 795                 800 


Thr Glu Ser Glu Lys Arg Pro Leu Ser Ile Gln Asp Ser Phe Val Glu 
                805                 810                 815     


Val Ser Pro Val Cys Pro Arg Pro Arg Val Arg Leu Gly Ser Glu Ile 
            820                 825                 830         


Arg Asp Ser Val Val 
        835         


<210>  95
<211>  6403
<212>  DNA
<213>  Homo sapiens

<400>  95
agtttcactt tcccttttgt aacgtcagct gaagggaaac aaacaaaaag gaaccagagg       60

ccacttgtat atataggtct cttcagcatt tattggtggc agaagaggaa gatttctgaa      120

gagtgcagct gcctgaaccg agccctgccg aacagctgag aattgcactg caaccatgag      180

tgagaacaat aagaattcct tggagagcag cctacggcaa ctaaaatgcc atttcacctg      240

gaacttgatg gagggagaaa actccttgga tgattttgaa gacaaagtat tttaccggac      300

tgagtttcag aatcgtgaat tcaaagccac aatgtgcaac ctactggcct atctaaagca      360

cctcaaaggg caaaacgagg cagccctgga atgcttacgt aaagctgaag agttaatcca      420

gcaagagcat gctgaccagg cagaaatcag aagtctggtc acctggggaa actatgcctg      480

ggtctactat cacatgggcc gactctcaga cgttcagatt tatgtagaca aggtgaaaca      540

tgtctgtgag aagttttcca gtccctatag aattgagagt ccagagcttg actgtgagga      600

agggtggaca cggttaaagt gtggaggaaa ccaaaatgaa agagcgaagg tgtgctttga      660

gaaggctctg gaaaagaagc caaagaaccc agaattcacc tctggactgg caatagcaag      720

ctaccgtctg gacaactggc caccatctca gaacgccatt gaccctctga ggcaagccat      780

tcggctgaat cctgacaacc agtaccttaa agtcctcctg gctctgaagc ttcataagat      840

gcgtgaagaa ggtgaagagg aaggtgaagg agagaagtta gttgaagaag ccttggagaa      900

agccccaggt gtaacagatg ttcttcgcag tgcagccaag ttttatcgaa gaaaagatga      960

gccagacaaa gcgattgaac tgcttaaaaa ggctttagaa tacataccaa acaatgccta     1020

cctgcattgc caaattgggt gctgctatag ggcaaaagtc ttccaagtaa tgaatctaag     1080

agagaatgga atgtatggga aaagaaagtt actggaacta ataggacacg ctgtggctca     1140

tctgaagaaa gctgatgagg ccaatgataa tctcttccgt gtctgttcca ttcttgccag     1200

cctccatgct ctagcagatc agtatgaaga cgcagagtat tacttccaaa aggaattcag     1260

taaagagctt actcctgtag cgaaacaact gctccatctg cggtatggca actttcagct     1320

gtaccaaatg aagtgtgaag acaaggccat ccaccacttt atagagggtg taaaaataaa     1380

ccagaaatca agggagaaag aaaagatgaa agacaaactg caaaaaattg ccaaaatgcg     1440

actttctaaa aatggagcag attctgaggc tttgcatgtc ttggcattcc ttcaggagct     1500

gaatgaaaaa atgcaacaag cagatgaaga ctctgagagg ggtttggagt ctggaagcct     1560

catcccttca gcatcaagct ggaatgggga atgaagaata gagatgtggt gcccactagg     1620

ctactgctga aagggagctg aaattcctcc accaagttgg tattcaaaat atgtaatgac     1680

tggtatggca aaagattgga ctaagacact ggccatacca ctggacaggg ttatgttaac     1740

acctgaattg ctgggtcttg agagagccca aggagttctg ggagagggac cagattgggg     1800

ggtaggtcca cgggcttggt gatagaatta tttctcgatt gacttcttga gtgcaatttg     1860

aactgtaaca tttgcttagt cacctttagt ggagtaatct actgggcttg tttctatatt     1920

tatataaagc agccaaatcc ttcatgtaat attgaagtcc atttttgcaa tgttgttcca     1980

tacttggagt cattttgcat cccatagagg ttagtcctgc atagccagta atgtgctaag     2040

ttcatccaaa agctggcgga ccaaagtcta aatagggctc agtatccccc atcgcttatc     2100

tctgcctcct tcctcctcct tcccagtcta tcatcaacct tgagtattct acacaatgtg     2160

aattcaagtg cctgattaat tgaggtggca acatagtttg agacgagggc agagaacagg     2220

aagatacata gctagaagcg acgggtacaa aaagcaatgt gtacaagaag actttcagca     2280

agtatacaga gagttcacct ctactctgcc ctcctcatag tcataatgta gcaagtaaag     2340

aatgagaatg gattctgtac aatacactag aaaccaacat aatgtatttc tttaaaacct     2400

gtgtgaaaaa ataaatgttc caccagtagg gataggggaa aagtaaccaa aagagagaaa     2460

gagaaaggaa tgctggttta tctttgtaga ttgtaatcga atggagaaat ttgcagtatt     2520

ttagccacta ttaggaattt tttttttttg taaaatgaag actgaactct gttcaaatgc     2580

tttcatgaac ctggtttgag acggtaggaa agcaacaaaa cgtgggaacc tggtgactaa     2640

gggcctggtg caaggacttg ggaaatgtca ttgataatag atggtggggt tttcccccct     2700

ttagaaatgt tggatattaa gtgatataaa cacttctttt aactccgaaa atcttctgag     2760

aaatcacaaa attcacggta tgcttggaac gattgagatt ttctaggtag atgctgaata     2820

gcctagacat caaagttggt gtgaaccaaa atagagtcag ctgacccagc atcagccaca     2880

ctctgggttg gaaaatgtag tttcactttc ccttttgtaa cgtcagctga agggaaacaa     2940

acaaaaagga accagaggcc acttgtatat ataggtctct tcagcattta ttggtggcag     3000

aagaggaaga tttctgaaga gtgcagctgc ctgaaccgag ccctgccgaa cagctgagaa     3060

ttgcactgca accatgagtg agaacaataa gaattccttg gagagcagcc tacggcaact     3120

aaaatgccat ttcacctgga acttgatgga gggagaaaac tccttggatg attttgaaga     3180

caaagtattt taccggactg agtttcagaa tcgtgaattc aaagccacaa tgtgcaacct     3240

actggcctat ctaaagcacc tcaaagggca aaacgaggca gccctggaat gcttacgtaa     3300

agctgaagag ttaatccagc aagagcatgc tgaccaggca gaaatcagaa gtctggtcac     3360

ctggggaaac tatgcctggg tctactatca catgggccga ctctcagacg ttcagattta     3420

tgtagacaag gtgaaacatg tctgtgagaa gttttccagt ccctatagaa ttgagagtcc     3480

agagcttgac tgtgaggaag ggtggacacg gttaaagtgt ggaggaaacc aaaatgaaag     3540

agcgaaggtg tgctttgaga aggctctgga aaagaagcca aagaacccag aattcacctc     3600

tggactggca atagcaagct accgtctgga caactggcca ccatctcaga acgccattga     3660

ccctctgagg caagccattc ggctgaatcc tgacaaccag taccttaaag tcctcctggc     3720

tctgaagctt cataagatgc gtgaagaagg tgaagaggaa ggtgaaggag agaagttagt     3780

tgaagaagcc ttggagaaag ccccaggtgt aacagatgtt cttcgcagtg cagccaagtt     3840

ttatcgaaga aaagatgagc cagacaaagc gattgaactg cttaaaaagg ctttagaata     3900

cataccaaac aatgcctacc tgcattgcca aattgggtgc tgctataggg caaaagtctt     3960

ccaagtaatg aatctaagag agaatggaat gtatgggaaa agaaagttac tggaactaat     4020

aggacacgct gtggctcatc tgaagaaagc tgatgaggcc aatgataatc tcttccgtgt     4080

ctgttccatt cttgccagcc tccatgctct agcagatcag tatgaagacg cagagtatta     4140

cttccaaaag gaattcagta aagagcttac tcctgtagcg aaacaactgc tccatctgcg     4200

gtatggcaac tttcagctgt accaaatgaa gtgtgaagac aaggccatcc accactttat     4260

agagggtgta aaaataaacc agaaatcaag ggagaaagaa aagatgaaag acaaactgca     4320

aaaaattgcc aaaatgcgac tttctaaaaa tggagcagat tctgaggctt tgcatgtctt     4380

ggcattcctt caggagctga atgaaaaaat gcaacaagca gatgaagact ctgagagggg     4440

tttggagtct ggaagcctca tcccttcagc atcaagctgg aatggggaat gaagaataga     4500

gatgtggtgc ccactaggct actgctgaaa gggagctgaa attcctccac caagttggta     4560

ttcaaaatat gtaatgactg gtatggcaaa agattggact aagacactgg ccataccact     4620

ggacagggtt atgttaacac ctgaattgct gggtcttgag agagcccaag gagttctggg     4680

agagggacca gattgggggg taggtccacg ggcttggtga tagaattatt tctcgattga     4740

cttcttgagt gcaatttgaa ctgtaacatt tgcttagtca cctttagtgg agtaatctac     4800

tgggcttgtt tctatattta tataaagcag ccaaatcctt catgtaatat tgaagtccat     4860

ttttgcaatg ttgttccata cttggagtca ttttgcatcc catagaggtt agtcctgcat     4920

agccagtaat gtgctaagtt catccaaaag ctggcggacc aaagtctaaa tagggctcag     4980

tatcccccat cgcttatctc tgcctccttc ctcctccttc ccagtctatc atcaaccttg     5040

agtattctac acaatgtgaa ttcaagtgcc tgattaattg aggtggcaac atagtttgag     5100

acgagggcag agaacaggaa gatacatagc tagaagcgac gggtacaaaa agcaatgtgt     5160

acaagaagac tttcagcaag tatacagaga gttcacctct actctgccct cctcatagtc     5220

ataatgtagc aagtaaagaa tgagaatgga ttctgtacaa tacactagaa accaacataa     5280

tgtatttctt taaaacctgt gtgaaaaaat aaatgttcca ccagtaggga taggggaaaa     5340

gtaaccaaaa gagagaaaga gaaaggaatg ctggtttatc tttgtagatt gtaatcgaat     5400

ggagaaattt gcagtatttt agccactatt aggaattttt tttttttgta aaatgaagac     5460

tgaactctgt tcaaatgctt tcatgaacct ggtttgagac ggtaggaaag caacaaaacg     5520

tgggaacctg gtgactaagg gcctggtgca aggacttggg aaatgtcatt gataatagat     5580

ggtggggttt tccccccttt agaaatgttg gatattaagt gatataaaca cttcttttaa     5640

ctccgaaaat cttctgagaa atcacaaaat tcacggtatg cttggaacga ttgagatttt     5700

ctaggtagat gctgaatagc ctagacatca aagttggtgt gaaccaaaat agagtcagct     5760

gacccagcat cagccacact ctgggttgga aaatgtttgc ctgttggaat taatttaagc     5820

ttaagtatat atcaacatta ttttattgtg caattaaaac aatacaaatt catggttttt     5880

taaagttaaa aattctaacc actgtaacaa cagtttttgt gttattttct gtattaaaca     5940

tcttgttgca cgcatttgag gtcatcaggg tgcaaaattt gtattcctga aaatgtcata     6000

tattttcatt aataaataac ctaaatatga taaaacataa agcagtgttc tggttcatct     6060

ggaattttgc tgtactttaa atctttcaga ctcagctact gataaatgaa acgttacaca     6120

ggtgtgaacc aaatccaaat aacctcgact ggtctactat cataatcacc tgaacagaac     6180

aaaacttttt cctcagcttt aagagtccag ggcttcggat aacagctgcc atctgccacc     6240

tgctaccatt gacctacgtg aacacagaca ttctgtctcc accttgatgg tgggtgggct     6300

gctccccttt tctttgttaa attttgtgct ttcatcacat tttctctatt ctgacctctg     6360

ttatgagaaa taaaagtcac tgattccatt ttaaaaaaaa aaa                       6403


<210>  96
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Glu Asn Asn Lys Asn Ser Leu Glu Ser Ser Leu Arg Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Met Glu Gly Glu Asn Ser Leu Asp 
            20                  25                  30          


Asp Phe Glu Asp Lys Val Phe Tyr Arg Thr Glu Phe Gln Asn Arg Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Cys Asn Leu Leu Ala Tyr Leu Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Glu Ala Ala Leu Glu Cys Leu Arg Lys Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Gly Arg Leu Ser Asp 
            100                 105                 110         


Val Gln Ile Tyr Val Asp Lys Val Lys His Val Cys Glu Lys Phe Ser 
        115                 120                 125             


Ser Pro Tyr Arg Ile Glu Ser Pro Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Arg Leu Lys Cys Gly Gly Asn Gln Asn Glu Arg Ala Lys Val Cys 
145                 150                 155                 160 


Phe Glu Lys Ala Leu Glu Lys Lys Pro Lys Asn Pro Glu Phe Thr Ser 
                165                 170                 175     


Gly Leu Ala Ile Ala Ser Tyr Arg Leu Asp Asn Trp Pro Pro Ser Gln 
            180                 185                 190         


Asn Ala Ile Asp Pro Leu Arg Gln Ala Ile Arg Leu Asn Pro Asp Asn 
        195                 200                 205             


Gln Tyr Leu Lys Val Leu Leu Ala Leu Lys Leu His Lys Met Arg Glu 
    210                 215                 220                 


Glu Gly Glu Glu Glu Gly Glu Gly Glu Lys Leu Val Glu Glu Ala Leu 
225                 230                 235                 240 


Glu Lys Ala Pro Gly Val Thr Asp Val Leu Arg Ser Ala Ala Lys Phe 
                245                 250                 255     


Tyr Arg Arg Lys Asp Glu Pro Asp Lys Ala Ile Glu Leu Leu Lys Lys 
            260                 265                 270         


Ala Leu Glu Tyr Ile Pro Asn Asn Ala Tyr Leu His Cys Gln Ile Gly 
        275                 280                 285             


Cys Cys Tyr Arg Ala Lys Val Phe Gln Val Met Asn Leu Arg Glu Asn 
    290                 295                 300                 


Gly Met Tyr Gly Lys Arg Lys Leu Leu Glu Leu Ile Gly His Ala Val 
305                 310                 315                 320 


Ala His Leu Lys Lys Ala Asp Glu Ala Asn Asp Asn Leu Phe Arg Val 
                325                 330                 335     


Cys Ser Ile Leu Ala Ser Leu His Ala Leu Ala Asp Gln Tyr Glu Asp 
            340                 345                 350         


Ala Glu Tyr Tyr Phe Gln Lys Glu Phe Ser Lys Glu Leu Thr Pro Val 
        355                 360                 365             


Ala Lys Gln Leu Leu His Leu Arg Tyr Gly Asn Phe Gln Leu Tyr Gln 
    370                 375                 380                 


Met Lys Cys Glu Asp Lys Ala Ile His His Phe Ile Glu Gly Val Lys 
385                 390                 395                 400 


Ile Asn Gln Lys Ser Arg Glu Lys Glu Lys Met Lys Asp Lys Leu Gln 
                405                 410                 415     


Lys Ile Ala Lys Met Arg Leu Ser Lys Asn Gly Ala Asp Ser Glu Ala 
            420                 425                 430         


Leu His Val Leu Ala Phe Leu Gln Glu Leu Asn Glu Lys Met Gln Gln 
        435                 440                 445             


Ala Asp Glu Asp Ser Glu Arg Gly Leu Glu Ser Gly Ser Leu Ile Pro 
    450                 455                 460                 


Ser Ala Ser Ser Trp Asn Gly Glu 
465                 470         


<210>  97
<211>  6646
<212>  DNA
<213>  Homo sapiens

<400>  97
gttcggagag ccgggcggga aaacgaaacc agaaatccga aggccgcgcc agagccctgc       60

ttccccttgc acctgcgccg ggcggccatg gacttgtaca gcaccccggc cgctgcgctg      120

gacaggttcg tggccagaag gctgcagccg cggaaggagt tcgtagagaa ggcgcggcgc      180

gctctgggcg ccctggccgc tgccctgagg gagcgcgggg gccgcctcgg tgctgctgcc      240

ccgcgggtgc tgaaaactgt caagggaggc tcctcgggcc ggggcacagc tctcaagggt      300

ggctgtgatt ctgaacttgt catcttcctc gactgcttca agagctatgt ggaccagagg      360

gcccgccgtg cagagatcct cagtgagatg cgggcatcgc tggaatcctg gtggcagaac      420

ccagtccctg gtctgagact cacgtttcct gagcagagcg tgcctggggc cctgcagttc      480

cgcctgacat ccgtagatct tgaggactgg atggatgtta gcctggtgcc tgccttcaat      540

gtcctgggtc aggccggctc cggcgtcaaa cccaagccac aagtctactc taccctcctc      600

aacagtggct gccaaggggg cgagcatgcg gcctgcttca cagagctgcg gaggaacttt      660

gtgaacattc gcccagccaa gttgaagaac ctaatcttgc tggtgaagca ctggtaccac      720

caggtgtgcc tacaggggtt gtggaaggag acgctgcccc cggtctatgc cctggaattg      780

ctgaccatct tcgcctggga gcagggctgt aagaaggatg ctttcagcct agccgaaggc      840

ctccgaactg tcctgggcct gatccaacag catcagcacc tgtgtgtttt ctggactgtc      900

aactatggct tcgaggaccc tgcagttggg cagttcttgc agcggcagct taagagaccc      960

aggcctgtga tcctggaccc agctgacccc acatgggacc tggggaatgg ggcagcctgg     1020

cactgggatt tgctagccca ggaggcagca tcctgctatg accacccatg ctttctgagg     1080

gggatggggg acccagtgca gtcttggaag gggccgggcc ttccacgtgc tggatgctca     1140

ggtttgggcc accccatcca gctagaccct aaccagaaga cccctgaaaa cagcaagagc     1200

ctcaatgctg tgtacccaag agcagggagc aaacctccct catgcccagc tcctggcccc     1260

actggggcag ccagcatcgt cccctctgtg ccgggaatgg ccttggacct gtctcagatc     1320

cccaccaagg agctggaccg cttcatccag gaccacctga agccgagccc ccagttccag     1380

gagcaggtga aaaaggccat cgacatcatc ttgcgctgcc tccatgagaa ctgtgttcac     1440

aaggcctcaa gagtcagtaa agggggctca tttggccggg gcacagacct aagggatggc     1500

tgtgatgttg aactcatcat cttcctcaac tgcttcacgg actacaagga ccaggggccc     1560

cgccgcgcag agatccttga tgagatgcga gcgcagctag aatcctggtg gcaggaccag     1620

gtgcccagcc tgagccttca gtttcctgag cagaatgtgc ctgaggctct gcagttccag     1680

ctggtgtcca cagccctgaa gagctggacg gatgttagcc tgctgcctgc cttcgatgct     1740

gtggggcagc tcagttctgg caccaaacca aatccccagg tctactcgag gctcctcacc     1800

agtggctgcc aggagggcga gcataaggcc tgcttcgcag agctgcggag gaacttcatg     1860

aacattcgcc ctgtcaagct gaagaacctg attctgctgg tgaagcactg gtaccgccag     1920

gttgcggctc agaacaaagg aaaaggacca gcccctgcct ctctgccccc agcctatgcc     1980

ctggagctcc tcaccatctt tgcctgggag cagggctgca ggcaggattg tttcaacatg     2040

gcccaaggct tccggacggt gctggggctc gtgcaacagc atcagcagct ctgtgtctac     2100

tggacggtca actatagcac tgaggaccca gccatgagaa tgcaccttct tggccagctt     2160

cgaaaaccca gacccctggt cctggacccc gctgatccca cctggaacgt gggccacggt     2220

agctgggagc tgttggccca ggaagcagca gcgctgggga tgcaggcctg ctttctgagt     2280

agagacggga catctgtgca gccctgggat gtgatgccag ccctccttta ccaaacccca     2340

gctggggacc ttgacaagtt catcagtgaa tttctccagc ccaaccgcca gttcctggcc     2400

caggtgaaca aggccgttga taccatctgt tcatttttga aggaaaactg cttccggaat     2460

tctcccatca aagtgatcaa ggtggtcaag ggtggctctt cagccaaagg cacagctctg     2520

cgaggccgct cagatgccga cctcgtggtg ttcctcagct gcttcagcca gttcactgag     2580

cagggcaaca agcgggccga gatcatctcc gagatccgag cccagctgga ggcatgtcaa     2640

caggagcggc agttcgaggt caagtttgaa gtctccaaat gggagaatcc ccgcgtgctg     2700

agcttctcac tgacatccca gacgatgctg gaccagagtg tggactttga tgtgctgcca     2760

gcctttgacg ccctaggcca gctggtctct ggctccaggc ccagctctca agtctacgtc     2820

gacctcatcc acagctacag caatgcgggc gagtactcca cctgcttcac agagctacaa     2880

cgggacttca tcatctctcg ccctaccaag ctgaagagcc tgatccggct ggtgaagcac     2940

tggtaccagc agtgtaccaa gatctccaag gggagaggct ccctaccccc acagcacggg     3000

ctggaactcc tgactgtgta tgcctgggag cagggcggga aggactccca gttcaacatg     3060

gctgagggct tccgcacggt cctggagctg gtcacccagt accgccagct ctgtatctac     3120

tggaccatca actacaacgc caaggacaag actgttggag acttcctgaa acagcagctt     3180

cagaagccca ggcctatcat cctggatccg gctgacccga caggcaacct gggccacaat     3240

gcccgctggg acctgctggc caaggaagct gcagcctgca catctgccct gtgctgcatg     3300

ggacggaatg gcatccccat ccagccatgg ccagtgaagg ctgctgtgtg aagttgagaa     3360

aatcagcggt cctactggat gaagagaaga tggacaccag ccctcagcat gaggaaattc     3420

agggtcccct accagatgag agagattgtg tacatgtgtg tgtgagcaca tgtgtgcatg     3480

tgtgtgcaca cgtgtgcatg tgtgtgtttt agtgaatctg ctctcccagc tcacacactc     3540

ccctgcctcc catggcttac acactaggat ccagactcca tggtttgaca ccagcctgcg     3600

tttgcagctt ctctgtcact tccatgactc tatcctcata ccaccactgc tgcttcccac     3660

ccagctgaga atgccccctc ctccctgact cctctctgcc catgcaaatt agctcacatc     3720

tttcctcctg ctgcaatcca tcccttcctc ccattggcct ctccttgcca aatctaaata     3780

gtttatatag ggatggcaga gagttcccat ctcatctgtc agccacagtc atttggtact     3840

ggctacctgg agccttatct tctgaagggt tttaaagaat ggccaattag ctgagaagaa     3900

ttatctaatc aattagtgat gtctgccatg gatgcagtag aggaaagtgg tggtacaagt     3960

gccatgattg attagcaatg tctgcactgg atacggaaaa aagaaggtgc ttgcaggttt     4020

acagtgtata tgtgggctat tgaagagccc tctgagctcg gttgctagca ggagagcatg     4080

cccatattgg cttactttgt ctgccacaga cacagacaga gggagttggg acatgcatgc     4140

tatggggacc ctcttgttgg acacctaatt ggatgcctct tcatgagagg cctccttttc     4200

ttcacctttt atgctgcact cctcccctag tttacacatc ttgatgctgt ggctcagttt     4260

gccttcctga atttttattg ggtccctgtt ttctctccta acatgctgag attctgcatc     4320

cccacagcct aaactgagcc agtggccaaa caaccgtgct cagcctgttt ctctctgccc     4380

tctagagcaa ggcccaccag gtccatccag gaggctctcc tgacctcaag tccaacaaca     4440

gtgtccacac tagtcaaggt tcagcccaga aaacagaaag cactctagga atcttaggca     4500

gaaagggatt ttatctaaat cactggaaag gctggaggag cagaaggcag aggccaccac     4560

tggactattg gtttcaatat tagaccactg tagccgaatc agaggccaga gagcagccac     4620

tgctactgct aatgccacca ctacccctgc catcactgcc ccacatggac aaaactggag     4680

tcgagaccta ggttagattc ctgcaaccac aaacatccat cagggatggc cagctgccag     4740

agctgcggga agacggatcc cacctccctt tcttagcaga atctaaatta cagccagacc     4800

tctggctgca gaggagtctg agacatgtat gattgaatgg gtgccaagtg ccagggggcg     4860

gagtccccag cagatgcatc ctggccatct gttgcgtgga tgagggagtg ggtctatctc     4920

agaggaagga acaggaaaca aagaaaggaa gccactgaac atcccttctc tgctccacag     4980

gagtgcctta gacagcctga ctctccacaa accactgtta aaacttacct gctaggaatg     5040

ctagattgaa tgggatggga agagccttcc ctcattattg tcattcttgg agagaggtga     5100

gcaaccaagg gaagctcctc tgattcacct agaacctgtt ctctgccgtc tttggctcag     5160

cctacagaga ctagagtagg tgaagggaca gaggacaggg cttctaatac ctgtgccata     5220

ttgacagcct ccatccctgt cccccatctt ggtgctgaac caacgctaag ggcaccttct     5280

tagactcacc tcatcgatac tgcctggtaa tccaaagcta gaactctcag gaccccaaac     5340

tccacctctt ggattggccc tggctgctgc cacacacata tccaagagct cagggccagt     5400

tctggtgggc agcagagacc tgctctgcca agttgtccag cagcagagtg gccctggcct     5460

gggcatcaca agccagtgat gctcctggga agaccaggtg gcaggtcgca gttgggtacc     5520

ttccattccc accacacaga ctctgggcct ccccgcaaaa tggctccaga attagagtaa     5580

ttatgagatg gtgggaacca gagcaactca ggtgcatgat acaaggagag gttgtcatct     5640

gggtagggca gagaggaggg cttgctcatc tgaacagggg tgtatttcat tccaggccct     5700

cagtctttgg caatggccac cctggtgttg gcatattggc cccactgtaa cttttggggg     5760

cttcccggtc tagccacacc ctcggatgga aagacttgac tgcataaaga tgtcagttct     5820

ccctgagttg attgataggc ttaatggtca ccctaaaaac acccacatat gcttttcgat     5880

ggaaccaggt aagttgacgc taaagttctt atggaaaaat acacacgcaa tagctaggaa     5940

aacacaggga aagaagagtt ctgagcaggg cctagtctta gccaatatta aaacatacta     6000

tgaagcctct gatacttaaa cagcatggcg ctggtacgta aatagaccaa tgcagttagg     6060

tggctctttc caagactctg gggaaaaaag tagtaaaaag ctaaatgcaa tcaatcagca     6120

attgaaagct aagtgagaga gccagagggc ctccttggtg gtaaaagagg gttgcatttc     6180

ttgcagccag aaggcagaga aagtgaagac caagtccaga actgaatcct aagaaatgca     6240

ggactgcaaa gaaattggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttaattttt     6300

aaaaagtttt tattgagata caagtcaata ccataaagct ctcacccttc taaagtgtac     6360

aattcagtgg tgtgagtata ttcataagat ttatacttgg tgtctattca taagacttat     6420

atccagcata ttcataacta gagccatatc acagatgcat tcatcataat aattccagac     6480

attttcatca ccctaaaagg aaaccctgaa acccattagc agtcattccc cattcctcca     6540

acccattctc tccctaatcc ctagaaacca ccaatctgct gtgtatttca tctattgcca     6600

acatttcata taaatggcat catacaaaaa aaaaaaaaaa aaaaaa                    6646


<210>  98
<211>  1731
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Asp Leu Tyr Ser Thr Pro Ala Ala Ala Leu Asp Arg Phe Val Ala 
1               5                   10                  15      


Arg Arg Leu Gln Pro Arg Lys Glu Phe Val Glu Lys Ala Arg Arg Ala 
            20                  25                  30          


Leu Gly Ala Leu Ala Ala Ala Leu Arg Glu Arg Gly Gly Arg Leu Gly 
        35                  40                  45              


Ala Ala Ala Pro Arg Val Leu Lys Thr Val Lys Gly Gly Ser Ser Gly 
    50                  55                  60                  


Arg Gly Thr Ala Leu Lys Gly Gly Cys Asp Ser Glu Leu Val Ile Phe 
65                  70                  75                  80  


Leu Asp Cys Phe Lys Ser Tyr Val Asp Gln Arg Ala Arg Arg Ala Glu 
                85                  90                  95      


Ile Leu Ser Glu Met Arg Ala Ser Leu Glu Ser Trp Trp Gln Asn Pro 
            100                 105                 110         


Val Pro Gly Leu Arg Leu Thr Phe Pro Glu Gln Ser Val Pro Gly Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Thr Ser Val Asp Leu Glu Asp Trp Met Asp Val 
    130                 135                 140                 


Ser Leu Val Pro Ala Phe Asn Val Leu Gly Gln Ala Gly Ser Gly Val 
145                 150                 155                 160 


Lys Pro Lys Pro Gln Val Tyr Ser Thr Leu Leu Asn Ser Gly Cys Gln 
                165                 170                 175     


Gly Gly Glu His Ala Ala Cys Phe Thr Glu Leu Arg Arg Asn Phe Val 
            180                 185                 190         


Asn Ile Arg Pro Ala Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His 
        195                 200                 205             


Trp Tyr His Gln Val Cys Leu Gln Gly Leu Trp Lys Glu Thr Leu Pro 
    210                 215                 220                 


Pro Val Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp Glu Gln Gly 
225                 230                 235                 240 


Cys Lys Lys Asp Ala Phe Ser Leu Ala Glu Gly Leu Arg Thr Val Leu 
                245                 250                 255     


Gly Leu Ile Gln Gln His Gln His Leu Cys Val Phe Trp Thr Val Asn 
            260                 265                 270         


Tyr Gly Phe Glu Asp Pro Ala Val Gly Gln Phe Leu Gln Arg Gln Leu 
        275                 280                 285             


Lys Arg Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro Thr Trp Asp 
    290                 295                 300                 


Leu Gly Asn Gly Ala Ala Trp His Trp Asp Leu Leu Ala Gln Glu Ala 
305                 310                 315                 320 


Ala Ser Cys Tyr Asp His Pro Cys Phe Leu Arg Gly Met Gly Asp Pro 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Pro Gly Leu Pro Arg Ala Gly Cys Ser Gly 
            340                 345                 350         


Leu Gly His Pro Ile Gln Leu Asp Pro Asn Gln Lys Thr Pro Glu Asn 
        355                 360                 365             


Ser Lys Ser Leu Asn Ala Val Tyr Pro Arg Ala Gly Ser Lys Pro Pro 
    370                 375                 380                 


Ser Cys Pro Ala Pro Gly Pro Thr Gly Ala Ala Ser Ile Val Pro Ser 
385                 390                 395                 400 


Val Pro Gly Met Ala Leu Asp Leu Ser Gln Ile Pro Thr Lys Glu Leu 
                405                 410                 415     


Asp Arg Phe Ile Gln Asp His Leu Lys Pro Ser Pro Gln Phe Gln Glu 
            420                 425                 430         


Gln Val Lys Lys Ala Ile Asp Ile Ile Leu Arg Cys Leu His Glu Asn 
        435                 440                 445             


Cys Val His Lys Ala Ser Arg Val Ser Lys Gly Gly Ser Phe Gly Arg 
    450                 455                 460                 


Gly Thr Asp Leu Arg Asp Gly Cys Asp Val Glu Leu Ile Ile Phe Leu 
465                 470                 475                 480 


Asn Cys Phe Thr Asp Tyr Lys Asp Gln Gly Pro Arg Arg Ala Glu Ile 
                485                 490                 495     


Leu Asp Glu Met Arg Ala Gln Leu Glu Ser Trp Trp Gln Asp Gln Val 
            500                 505                 510         


Pro Ser Leu Ser Leu Gln Phe Pro Glu Gln Asn Val Pro Glu Ala Leu 
        515                 520                 525             


Gln Phe Gln Leu Val Ser Thr Ala Leu Lys Ser Trp Thr Asp Val Ser 
    530                 535                 540                 


Leu Leu Pro Ala Phe Asp Ala Val Gly Gln Leu Ser Ser Gly Thr Lys 
545                 550                 555                 560 


Pro Asn Pro Gln Val Tyr Ser Arg Leu Leu Thr Ser Gly Cys Gln Glu 
                565                 570                 575     


Gly Glu His Lys Ala Cys Phe Ala Glu Leu Arg Arg Asn Phe Met Asn 
            580                 585                 590         


Ile Arg Pro Val Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His Trp 
        595                 600                 605             


Tyr Arg Gln Val Ala Ala Gln Asn Lys Gly Lys Gly Pro Ala Pro Ala 
    610                 615                 620                 


Ser Leu Pro Pro Ala Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp 
625                 630                 635                 640 


Glu Gln Gly Cys Met Asp Leu Tyr Ser Thr Pro Ala Ala Ala Leu Asp 
                645                 650                 655     


Arg Phe Val Ala Arg Arg Leu Gln Pro Arg Lys Glu Phe Val Glu Lys 
            660                 665                 670         


Ala Arg Arg Ala Leu Gly Ala Leu Ala Ala Ala Leu Arg Glu Arg Gly 
        675                 680                 685             


Gly Arg Leu Gly Ala Ala Ala Pro Arg Val Leu Lys Thr Val Lys Gly 
    690                 695                 700                 


Gly Ser Ser Gly Arg Gly Thr Ala Leu Lys Gly Gly Cys Asp Ser Glu 
705                 710                 715                 720 


Leu Val Ile Phe Leu Asp Cys Phe Lys Ser Tyr Val Asp Gln Arg Ala 
                725                 730                 735     


Arg Arg Ala Glu Ile Leu Ser Glu Met Arg Ala Ser Leu Glu Ser Trp 
            740                 745                 750         


Trp Gln Asn Pro Val Pro Gly Leu Arg Leu Thr Phe Pro Glu Gln Ser 
        755                 760                 765             


Val Pro Gly Ala Leu Gln Phe Arg Leu Thr Ser Val Asp Leu Glu Asp 
    770                 775                 780                 


Trp Met Asp Val Ser Leu Val Pro Ala Phe Asn Val Leu Gly Gln Ala 
785                 790                 795                 800 


Gly Ser Gly Val Lys Pro Lys Pro Gln Val Tyr Ser Thr Leu Leu Asn 
                805                 810                 815     


Ser Gly Cys Gln Gly Gly Glu His Ala Ala Cys Phe Thr Glu Leu Arg 
            820                 825                 830         


Arg Asn Phe Val Asn Ile Arg Pro Ala Lys Leu Lys Asn Leu Ile Leu 
        835                 840                 845             


Leu Val Lys His Trp Tyr His Gln Val Cys Leu Gln Gly Leu Trp Lys 
    850                 855                 860                 


Glu Thr Leu Pro Pro Val Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala 
865                 870                 875                 880 


Trp Glu Gln Gly Cys Lys Lys Asp Ala Phe Ser Leu Ala Glu Gly Leu 
                885                 890                 895     


Arg Thr Val Leu Gly Leu Ile Gln Gln His Gln His Leu Cys Val Phe 
            900                 905                 910         


Trp Thr Val Asn Tyr Gly Phe Glu Asp Pro Ala Val Gly Gln Phe Leu 
        915                 920                 925             


Gln Arg Gln Leu Lys Arg Pro Arg Pro Val Ile Leu Asp Pro Ala Asp 
    930                 935                 940                 


Pro Thr Trp Asp Leu Gly Asn Gly Ala Ala Trp His Trp Asp Leu Leu 
945                 950                 955                 960 


Ala Gln Glu Ala Ala Ser Cys Tyr Asp His Pro Cys Phe Leu Arg Gly 
                965                 970                 975     


Met Gly Asp Pro Val Gln Ser Trp Lys Gly Pro Gly Leu Pro Arg Ala 
            980                 985                 990         


Gly Cys Ser Gly Leu Gly His Pro  Ile Gln Leu Asp Pro  Asn Gln Lys 
        995                 1000                 1005             


Thr Pro  Glu Asn Ser Lys Ser  Leu Asn Ala Val Tyr  Pro Arg Ala 
    1010                 1015                 1020             


Gly Ser  Lys Pro Pro Ser Cys  Pro Ala Pro Gly Pro  Thr Gly Ala 
    1025                 1030                 1035             


Ala Ser  Ile Val Pro Ser Val  Pro Gly Met Ala Leu  Asp Leu Ser 
    1040                 1045                 1050             


Gln Ile  Pro Thr Lys Glu Leu  Asp Arg Phe Ile Gln  Asp His Leu 
    1055                 1060                 1065             


Lys Pro  Ser Pro Gln Phe Gln  Glu Gln Val Lys Lys  Ala Ile Asp 
    1070                 1075                 1080             


Ile Ile  Leu Arg Cys Leu His  Glu Asn Cys Val His  Lys Ala Ser 
    1085                 1090                 1095             


Arg Val  Ser Lys Gly Gly Ser  Phe Gly Arg Gly Thr  Asp Leu Arg 
    1100                 1105                 1110             


Asp Gly  Cys Asp Val Glu Leu  Ile Ile Phe Leu Asn  Cys Phe Thr 
    1115                 1120                 1125             


Asp Tyr  Lys Asp Gln Gly Pro  Arg Arg Ala Glu Ile  Leu Asp Glu 
    1130                 1135                 1140             


Met Arg  Ala Gln Leu Glu Ser  Trp Trp Gln Asp Gln  Val Pro Ser 
    1145                 1150                 1155             


Leu Ser  Leu Gln Phe Pro Glu  Gln Asn Val Pro Glu  Ala Leu Gln 
    1160                 1165                 1170             


Phe Gln  Leu Val Ser Thr Ala  Leu Lys Ser Trp Thr  Asp Val Ser 
    1175                 1180                 1185             


Leu Leu  Pro Ala Phe Asp Ala  Val Gly Gln Leu Ser  Ser Gly Thr 
    1190                 1195                 1200             


Lys Pro  Asn Pro Gln Val Tyr  Ser Arg Leu Leu Thr  Ser Gly Cys 
    1205                 1210                 1215             


Gln Glu  Gly Glu His Lys Ala  Cys Phe Ala Glu Leu  Arg Arg Asn 
    1220                 1225                 1230             


Phe Met  Asn Ile Arg Pro Val  Lys Leu Lys Asn Leu  Ile Leu Leu 
    1235                 1240                 1245             


Val Lys  His Trp Tyr Arg Gln  Val Ala Ala Gln Asn  Lys Gly Lys 
    1250                 1255                 1260             


Gly Pro  Ala Pro Ala Ser Leu  Pro Pro Ala Tyr Ala  Leu Glu Leu 
    1265                 1270                 1275             


Leu Thr  Ile Phe Ala Trp Glu  Gln Gly Cys Arg Gln  Asp Cys Phe 
    1280                 1285                 1290             


Asn Met  Ala Gln Gly Phe Arg  Thr Val Leu Gly Leu  Val Gln Gln 
    1295                 1300                 1305             


His Gln  Gln Leu Cys Val Tyr  Trp Thr Val Asn Tyr  Ser Thr Glu 
    1310                 1315                 1320             


Asp Pro  Ala Met Arg Met His  Leu Leu Gly Gln Leu  Arg Lys Pro 
    1325                 1330                 1335             


Arg Pro  Leu Val Leu Asp Pro  Ala Asp Pro Thr Trp  Asn Val Gly 
    1340                 1345                 1350             


His Gly  Ser Trp Glu Leu Leu  Ala Gln Glu Ala Ala  Ala Leu Gly 
    1355                 1360                 1365             


Met Gln  Ala Cys Phe Leu Ser  Arg Asp Gly Thr Ser  Val Gln Pro 
    1370                 1375                 1380             


Trp Asp  Val Met Pro Ala Leu  Leu Tyr Gln Thr Pro  Ala Gly Asp 
    1385                 1390                 1395             


Leu Asp  Lys Phe Ile Ser Glu  Phe Leu Gln Pro Asn  Arg Gln Phe 
    1400                 1405                 1410             


Leu Ala  Gln Val Asn Lys Ala  Val Asp Thr Ile Cys  Ser Phe Leu 
    1415                 1420                 1425             


Lys Glu  Asn Cys Phe Arg Asn  Ser Pro Ile Lys Val  Ile Lys Val 
    1430                 1435                 1440             


Val Lys  Gly Gly Ser Ser Ala  Lys Gly Thr Ala Leu  Arg Gly Arg 
    1445                 1450                 1455             


Ser Asp  Ala Asp Leu Val Val  Phe Leu Ser Cys Phe  Ser Gln Phe 
    1460                 1465                 1470             


Thr Glu  Gln Gly Asn Lys Arg  Ala Glu Ile Ile Ser  Glu Ile Arg 
    1475                 1480                 1485             


Ala Gln  Leu Glu Ala Cys Gln  Gln Glu Arg Gln Phe  Glu Val Lys 
    1490                 1495                 1500             


Phe Glu  Val Ser Lys Trp Glu  Asn Pro Arg Val Leu  Ser Phe Ser 
    1505                 1510                 1515             


Leu Thr  Ser Gln Thr Met Leu  Asp Gln Ser Val Asp  Phe Asp Val 
    1520                 1525                 1530             


Leu Pro  Ala Phe Asp Ala Leu  Gly Gln Leu Val Ser  Gly Ser Arg 
    1535                 1540                 1545             


Pro Ser  Ser Gln Val Tyr Val  Asp Leu Ile His Ser  Tyr Ser Asn 
    1550                 1555                 1560             


Ala Gly  Glu Tyr Ser Thr Cys  Phe Thr Glu Leu Gln  Arg Asp Phe 
    1565                 1570                 1575             


Ile Ile  Ser Arg Pro Thr Lys  Leu Lys Ser Leu Ile  Arg Leu Val 
    1580                 1585                 1590             


Lys His  Trp Tyr Gln Gln Cys  Thr Lys Ile Ser Lys  Gly Arg Gly 
    1595                 1600                 1605             


Ser Leu  Pro Pro Gln His Gly  Leu Glu Leu Leu Thr  Val Tyr Ala 
    1610                 1615                 1620             


Trp Glu  Gln Gly Gly Lys Asp  Ser Gln Phe Asn Met  Ala Glu Gly 
    1625                 1630                 1635             


Phe Arg  Thr Val Leu Glu Leu  Val Thr Gln Tyr Arg  Gln Leu Cys 
    1640                 1645                 1650             


Ile Tyr  Trp Thr Ile Asn Tyr  Asn Ala Lys Asp Lys  Thr Val Gly 
    1655                 1660                 1665             


Asp Phe  Leu Lys Gln Gln Leu  Gln Lys Pro Arg Pro  Ile Ile Leu 
    1670                 1675                 1680             


Asp Pro  Ala Asp Pro Thr Gly  Asn Leu Gly His Asn  Ala Arg Trp 
    1685                 1690                 1695             


Asp Leu  Leu Ala Lys Glu Ala  Ala Ala Cys Thr Ser  Ala Leu Cys 
    1700                 1705                 1710             


Cys Met  Gly Arg Asn Gly Ile  Pro Ile Gln Pro Trp  Pro Val Lys 
    1715                 1720                 1725             


Ala Ala  Val 
    1730     


<210>  99
<211>  4488
<212>  DNA
<213>  Homo sapiens

<400>  99
actttccttt cccctttcat aaaagcacag acctaacagc accctgggtg gaaacctctt       60

cagcatttgc ttggaatcag taagctaaaa acaaaatcaa ccgggacccc agcttttcag      120

aactgcaggg aaacagccat catgagtgag gtcaccaaga attccctgga gaaaatcctt      180

ccacagctga aatgccattt cacctggaac ttattcaagg aagacagtgt ctcaagggat      240

ctagaagata gagtgtgtaa ccagattgaa tttttaaaca ctgagttcaa agctacaatg      300

tacaacttgt tggcctacat aaaacaccta gatggtaaca acgaggcagc cctggaatgc      360

ttacggcaag ctgaagagtt aatccagcaa gaacatgctg accaagcaga aatcagaagt      420

ctagtcactt ggggaaacta cgcctgggtc tactatcact tgggcagact ctcagatgct      480

cagatttatg tagataaggt gaaacaaacc tgcaagaaat tttcaaatcc atacagtatt      540

gagtattctg aacttgactg tgaggaaggg tggacacaac tgaagtgtgg aagaaatgaa      600

agggcgaagg tgtgttttga gaaggctctg gaagaaaagc ccaacaaccc agaattctcc      660

tctggactgg caattgcgat gtaccatctg gataatcacc cagagaaaca gttctctact      720

gatgttttga agcaggccat tgagctgagt cctgataacc aatacgtcaa ggttctcttg      780

ggcctgaaac tgcagaagat gaataaagaa gctgaaggag agcagtttgt tgaagaagcc      840

ttggaaaagt ctccttgcca aacagatgtc ctccgcagtg cagccaaatt ttacagaaga      900

aaaggtgacc tagacaaagc tattgaactg tttcaacggg tgttggaatc cacaccaaac      960

aatggctacc tctatcacca gattgggtgc tgctacaagg caaaagtaag acaaatgcag     1020

aatacaggag aatctgaagc tagtggaaat aaagagatga ttgaagcact aaagcaatat     1080

gctatggact attcgaataa agctcttgag aagggactga atcctctgaa tgcatactcc     1140

gatctcgctg agttcctgga gacggaatgt tatcagacac cattcaataa ggaagtccct     1200

gatgctgaaa agcaacaatc ccatcagcgc tactgcaacc ttcagaaata taatgggaag     1260

tctgaagaca ctgctgtgca acatggttta gagggtttgt ccataagcaa aaaatcaact     1320

gacaaggaag agatcaaaga ccaaccacag aatgtatctg aaaatctgct tccacaaaat     1380

gcaccaaatt attggtatct tcaaggatta attcataagc agaatggaga tctgctgcaa     1440

gcagccaaat gttatgagaa ggaactgggc cgcctgctaa gggatgcccc ttcaggcata     1500

ggcagtattt tcctgtcagc atctgagctt gaggatggta gtgaggaaat gggccagggc     1560

gcagtcagct ccagtcccag agagctcctc tctaactcag agcaactgaa ctgagacaga     1620

ggaggaaaac agagcatcag aagcctgcag tggtggttgt gacgggtagg acgataggaa     1680

gacagggggc cccaacctgg gattgctgag cagggaagct ttgcatgttg ctctaaggta     1740

catttttaaa gagttgtttt ttggccgggc gcagtggctc atgcctgtaa tcccagcact     1800

ttgggaggcc gaggtgggcg gatcacgagg tctggagttt gagaccatcc tggctaacac     1860

agtgaaatcc cgtctctact aaaaatacaa aaaattagcc aggcgtggtg gctggcacct     1920

gtagtcccag ctacttggga ggctgaggca ggagaatggc gtgaacctgg aaggaagagg     1980

ttgcagtgag ccaagattgc gcccctgcac tccagcctgg gcaaactttc ctttcccctt     2040

tcataaaagc acagacctaa cagcaccctg ggtggaaacc tcttcagcat ttgcttggaa     2100

tcagtaagct aaaaacaaaa tcaaccggga ccccagcttt tcagaactgc agggaaacag     2160

ccatcatgag tgaggtcacc aagaattccc tggagaaaat ccttccacag ctgaaatgcc     2220

atttcacctg gaacttattc aaggaagaca gtgtctcaag ggatctagaa gatagagtgt     2280

gtaaccagat tgaattttta aacactgagt tcaaagctac aatgtacaac ttgttggcct     2340

acataaaaca cctagatggt aacaacgagg cagccctgga atgcttacgg caagctgaag     2400

agttaatcca gcaagaacat gctgaccaag cagaaatcag aagtctagtc acttggggaa     2460

actacgcctg ggtctactat cacttgggca gactctcaga tgctcagatt tatgtagata     2520

aggtgaaaca aacctgcaag aaattttcaa atccatacag tattgagtat tctgaacttg     2580

actgtgagga agggtggaca caactgaagt gtggaagaaa tgaaagggcg aaggtgtgtt     2640

ttgagaaggc tctggaagaa aagcccaaca acccagaatt ctcctctgga ctggcaattg     2700

cgatgtacca tctggataat cacccagaga aacagttctc tactgatgtt ttgaagcagg     2760

ccattgagct gagtcctgat aaccaatacg tcaaggttct cttgggcctg aaactgcaga     2820

agatgaataa agaagctgaa ggagagcagt ttgttgaaga agccttggaa aagtctcctt     2880

gccaaacaga tgtcctccgc agtgcagcca aattttacag aagaaaaggt gacctagaca     2940

aagctattga actgtttcaa cgggtgttgg aatccacacc aaacaatggc tacctctatc     3000

accagattgg gtgctgctac aaggcaaaag taagacaaat gcagaataca ggagaatctg     3060

aagctagtgg aaataaagag atgattgaag cactaaagca atatgctatg gactattcga     3120

ataaagctct tgagaaggga ctgaatcctc tgaatgcata ctccgatctc gctgagttcc     3180

tggagacgga atgttatcag acaccattca ataaggaagt ccctgatgct gaaaagcaac     3240

aatcccatca gcgctactgc aaccttcaga aatataatgg gaagtctgaa gacactgctg     3300

tgcaacatgg tttagagggt ttgtccataa gcaaaaaatc aactgacaag gaagagatca     3360

aagaccaacc acagaatgta tctgaaaatc tgcttccaca aaatgcacca aattattggt     3420

atcttcaagg attaattcat aagcagaatg gagatctgct gcaagcagcc aaatgttatg     3480

agaaggaact gggccgcctg ctaagggatg ccccttcagg cataggcagt attttcctgt     3540

cagcatctga gcttgaggat ggtagtgagg aaatgggcca gggcgcagtc agctccagtc     3600

ccagagagct cctctctaac tcagagcaac tgaactgaga cagaggagga aaacagagca     3660

tcagaagcct gcagtggtgg ttgtgacggg taggacgata ggaagacagg gggccccaac     3720

ctgggattgc tgagcaggga agctttgcat gttgctctaa ggtacatttt taaagagttg     3780

ttttttggcc gggcgcagtg gctcatgcct gtaatcccag cactttggga ggccgaggtg     3840

ggcggatcac gaggtctgga gtttgagacc atcctggcta acacagtgaa atcccgtctc     3900

tactaaaaat acaaaaaatt agccaggcgt ggtggctggc acctgtagtc ccagctactt     3960

gggaggctga ggcaggagaa tggcgtgaac ctggaaggaa gaggttgcag tgagccaaga     4020

ttgcgcccct gcactccagc ctgggcaaca gagcaagact ccatctcaaa aaaaaaaaaa     4080

aaaaaaaaaa agagttgttt tctcatgttc attatagttc attacagtta catagtccga     4140

aggtcttaca actaatcact ggtagcaata aatgcttcag gcccacatga tgctgattag     4200

ttctcagttt tcattcagtt cacaatataa ccaccattcc tgccctccct gccaagggtc     4260

ataaatggtg actgcctaac aacaaaattt gcagtctcat ctcattttca tccagacttc     4320

tggaactcaa agattaactt ttgactaacc ctggaatatc tcttatctca cttatagctt     4380

caggcatgta tttatatgta ttcttgatag caataccata atcaatgtgt attcctgata     4440

gtaatgctac aataaatcca aacatttcaa ctctgttaaa aaaaaaaa                  4488


<210>  100
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  101
<211>  3984
<212>  DNA
<213>  Homo sapiens

<400>  101
attttcctcc tcccaacgat tttaaattag tttcactttc cagtttcctc ttccttcccc       60

taaaagcaat tactcaaaaa cggagaaaac atcagctgat gcgtgcccta ctctcccacc      120

cctttatata gttccttcag tatttacttg aggcagacag gaagacttct gaagaacaaa      180

tcagcctggt caccagcttt tcggaacagc agagacacag agggcagtca tgagtgaggt      240

caccaagaat tccctggaga aaatccttcc acagctgaaa tgccatttca cctggaactt      300

attcaaggaa gacagtgtct caagggatct agaagataga gtgtgtaacc agattgaatt      360

tttaaacact gagttcaaag ctacaatgta caacttgttg gcctacataa aacacctaga      420

tggtaacaac gaggcagccc tggaatgctt acggcaagct gaagagttaa tccagcaaga      480

acatgctgac caagcagaaa tcagaagtct agtcacttgg ggaaactacg cctgggtcta      540

ctatcacttg ggcagactct cagatgctca gatttatgta gataaggtga aacaaacctg      600

caagaaattt tcaaatccat acagtattga gtattctgaa cttgactgtg aggaagggtg      660

gacacaactg aagtgtggaa gaaatgaaag ggcgaaggtg tgttttgaga aggctctgga      720

agaaaagccc aacaacccag aattctcctc tggactggca attgcgatgt accatctgga      780

taatcaccca gagaaacagt tctctactga tgttttgaag caggccattg agctgagtcc      840

tgataaccaa tacgtcaagg ttctcttggg cctgaaactg cagaagatga ataaagaagc      900

tgaaggagag cagtttgttg aagaagcctt ggaaaagtct ccttgccaaa cagatgtcct      960

ccgcagtgca gccaaatttt acagaagaaa aggtgaccta gacaaagcta ttgaactgtt     1020

tcaacgggtg ttggaatcca caccaaacaa tggctacctc tatcaccaga ttgggtgctg     1080

ctacaaggca aaagtaagac aaatgcagaa tacaggagaa tctgaagcta gtggaaataa     1140

agagatgatt gaagcactaa agcaatatgc tatggactat tcgaataaag ctcttgagaa     1200

gggactgaat cctctgaatg catactccga tctcgctgag ttcctggaga cggaatgtta     1260

tcagacacca ttcaataagg aagtccctga tgctgaaaag caacaatccc atcagcgcta     1320

ctgcaacctt cagaaatata atgggaagtc tgaagacact gctgtgcaac atggtttaga     1380

gggtttgtcc ataagcaaaa aatcaactga caaggaagag atcaaagacc aaccacagaa     1440

tgtatctgaa aatctgcttc cacaaaatgc accaaattat tggtatcttc aaggattaat     1500

tcataagcag aatggagatc tgctgcaagc agccaaatgt tatgagaagg aactgggccg     1560

cctgctaagg gatgcccctt caggcatagg cagtattttc ctgtcagcat ctgagcttga     1620

ggatggtagt gaggaaatgg gccagggcgc agtcagctcc agtcccagag agctcctctc     1680

taactcagag caactgaact gagacagagg aggaaaacag agcatcagaa gcctgcagtg     1740

gtggttgtga cgggtaggac gataggaaga cagggggccc caacctggga ttgctgagca     1800

gggaagcttt gcatgttgct ctaaggtaca tttttaaaga gttgtttttt ggccgggcgc     1860

agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacgaggtc     1920

tggagtttga gaccatcctg gctaacacag tgaaatcccg tctctactaa aaatacaaaa     1980

aattagccag gcgtggtggc tggcacctgt agtcccagct acttgggagg ctgaggcagg     2040

agaatggcgt gaacctggaa ggaagaggtt gcagtgagcc aagattgcgc ccctgcactc     2100

cagcctgggc aacagagcaa gactccatct caaaaaaaaa aaaaaaaaaa aaaaagagtt     2160

gttttctcat gttcattata gttcattaca gttacatagt ccgaaggtct tacaactaat     2220

cactggtagc aataaatgct tcaggcccac atgatgctga ttagttctca gttttcattc     2280

agttcacaat ataaccacca ttcctgccct ccctgccaag ggtcataaat ggtgactgcc     2340

taacaacaaa atttgcagtc tcatctcatt ttcatccaga cttctggaac tcaaagatta     2400

acttttgact aaccctggaa tatctcttat ctcacttata gcttcaggca tgtatttata     2460

tgtattcttg atagcaatac cataatcaat gtgtattcct gatagtaatg ctacaataaa     2520

tccaaacatt tcaactctgt taaaaaaaaa aatctgaagc tagtggaaat aaagagatga     2580

ttgaagcact aaagcaatat gctatggact attcgaataa agctcttgag aagggactga     2640

atcctctgaa tgcatactcc gatctcgctg agttcctgga gacggaatgt tatcagacac     2700

cattcaataa ggaagtccct gatgctgaaa agcaacaatc ccatcagcgc tactgcaacc     2760

ttcagaaata taatgggaag tctgaagaca ctgctgtgca acatggttta gagggtttgt     2820

ccataagcaa aaaatcaact gacaaggaag agatcaaaga ccaaccacag aatgtatctg     2880

aaaatctgct tccacaaaat gcaccaaatt attggtatct tcaaggatta attcataagc     2940

agaatggaga tctgctgcaa gcagccaaat gttatgagaa ggaactgggc cgcctgctaa     3000

gggatgcccc ttcaggcata ggcagtattt tcctgtcagc atctgagctt gaggatggta     3060

gtgaggaaat gggccagggc gcagtcagct ccagtcccag agagctcctc tctaactcag     3120

agcaactgaa ctgagacaga ggaggaaaac agagcatcag aagcctgcag tggtggttgt     3180

gacgggtagg acgataggaa gacagggggc cccaacctgg gattgctgag cagggaagct     3240

ttgcatgttg ctctaaggta catttttaaa gagttgtttt ttggccgggc gcagtggctc     3300

atgcctgtaa tcccagcact ttgggaggcc gaggtgggcg gatcacgagg tctggagttt     3360

gagaccatcc tggctaacac agtgaaatcc cgtctctact aaaaatacaa aaaattagcc     3420

aggcgtggtg gctggcacct gtagtcccag ctacttggga ggctgaggca ggagaatggc     3480

gtgaacctgg aaggaagagg ttgcagtgag ccaagattgc gcccctgcac tccagcctgg     3540

gcaacagagc aagactccat ctcaaaaaaa aaaaaaaaaa aaaaaaagag ttgttttctc     3600

atgttcatta tagttcatta cagttacata gtccgaaggt cttacaacta atcactggta     3660

gcaataaatg cttcaggccc acatgatgct gattagttct cagttttcat tcagttcaca     3720

atataaccac cattcctgcc ctccctgcca agggtcataa atggtgactg cctaacaaca     3780

aaatttgcag tctcatctca ttttcatcca gacttctgga actcaaagat taacttttga     3840

ctaaccctgg aatatctctt atctcactta tagcttcagg catgtattta tatgtattct     3900

tgatagcaat accataatca atgtgtattc ctgatagtaa tgctacaata aatccaaaca     3960

tttcaactct gttaaaaaaa aaaa                                            3984


<210>  102
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  103
<211>  7845
<212>  DNA
<213>  Homo sapiens

<400>  103
gcaaggacac acccacagct tacaccattg gctgctgttt agctccctta tataacactg       60

tcttggggtt taaacgtaac tgaaaatcca caagacagaa tagccagatc tcagaggagc      120

ctggctaagc aaaaccctgc agaacggctg cctaatttac agcaaccatg agtacaaatg      180

gtgatgatca tcaggtcaag gatagtctgg agcaattgag atgtcacttt acatgggagt      240

tatccattga tgacgatgaa atgcctgatt tagaaaacag agtcttggat cagattgaat      300

tcctagacac caaatacagt gtgggaatac acaacctact agcctatgtg aaacacctga      360

aaggccagaa tgaggaagcc ctgaagagct taaaagaagc tgaaaactta atgcaggaag      420

aacatgacaa ccaagcaaat gtgaggagtc tggtgacctg gggcaacttt gcctggatgt      480

attaccacat gggcagactg gcagaagccc agacttacct ggacaaggtg gagaacattt      540

gcaagaagct ttcaaatccc ttccgctata gaatggagtg tccagaaata gactgtgagg      600

aaggatgggc cttgctgaag tgtggaggaa aaaattatga acgggccaag gcctgctttg      660

aaaaggtgct tgaagtggac cctgaaaacc ctgaatccag cgctgggtat gcgatctctg      720

cctatcgcct ggatggcttt aaattagcca caaaaaatca caagccattt tctttgcttc      780

ccctaaggca ggctgtccgc ttaaatccag acaatggata tattaaggtt ctccttgccc      840

tgaagcttca ggatgaagga caggaagctg aaggagaaaa gtacattgaa gaagctctag      900

ccaacatgtc ctcacagacc tatgtctttc gatatgcagc caagttttac cgaagaaaag      960

gctctgtgga taaagctctt gagttattaa aaaaggcctt gcaggaaaca cccacttctg     1020

tcttactgca tcaccagata gggctttgct acaaggcaca aatgatccaa atcaaggagg     1080

ctacaaaagg gcagcctaga gggcagaaca gagaaaagct agacaaaatg ataagatcag     1140

ccatatttca ttttgaatct gcagtggaaa aaaagcccac atttgaggtg gctcatctag     1200

acctggcaag aatgtatata gaagcaggca atcacagaaa agctgaagag aattttcaaa     1260

aattgttatg catgaaacca gtggtagaag aaacaatgca agacatacat ttccactatg     1320

gtcggtttca ggaatttcaa aagaaatctg acgtcaatgc aattatccat tatttaaaag     1380

ctataaaaat agaacaggca tcattaacaa gggataaaag tatcaattct ttgaagaaat     1440

tggttttaag gaaacttcgg agaaaggcat tagatctgga aagcttgagc ctccttgggt     1500

tcgtctacaa attggaagga aatatgaatg aagccctgga gtactatgag cgggccctga     1560

gactggctgc tgactttgag aactctgtga gacaaggtcc ttaggcaccc agatatcagc     1620

cactttcaca tttcatttca ttttatgcta acatttacta atcatctttt ctgcttactg     1680

ttttcagaaa cattataatt cactgtaatg atgtaattct tgaataataa atctgacaaa     1740

atattagttg tgttcaacaa ttagtgaaac agaatgtgtg tatgcatgta agaaagagaa     1800

atcatttgta tgagtgctat gtagtagaga aaaaatgtta gttaactttg taggaaataa     1860

aacattggac ttacactaaa tgtttaattc attcatttta ttgtgaaata aaaataaaat     1920

ccttagctcc tccaccaact gaacagaccc tcttggccaa ggagacccca gaaaccttaa     1980

aaactaagtt tcccaaccat gacaagatga gagatcattc acacctcatt atattccctc     2040

ccttgctaac tgccattgga ctttttccac tgagttaaac agaaacccat ggaaaacaaa     2100

gaacagaaga ctcactcctt ggctgacttc acctagctca ctccacgtag cgccacagcc     2160

agactcccct cccctcttgc ggtttccaca tgacaactga tcagccttcc ctcctgataa     2220

gtgaccactg cccacagact ggttctggcc agtccatgga ggctgcacac agggtgcctc     2280

tatgtccttt gtttcacctt ttgatataga aaggctaatt ttgctgtatt ttaatgttaa     2340

gtctccacca cagagtgaac acagaatgca tgtgacatac atgtttacat accactattg     2400

tgtgactgcc cctcatgaat attcatagcc ccccataacc tgttaactat gtgtgtctag     2460

ccaatccacc aaccataaaa cttctgtaat accctccctt cctccaagag cctgcttttg     2520

gttgctgtgg taggctctgc ttcccaggct gcaggttgca ggagaggagg ctgcagtggc     2580

tcacgcctgt aatctcagca cttcgatggg acgaggcagg cagatcacct gaacccagga     2640

gttcgagagc agccttggca atggcaaaac caaccgtctc tacaaaaaat gcaaaaactt     2700

agctgggtgt ggtggcatgc acctgtagct tcagttccag ctactcagga ggctgaggtg     2760

agtggactgc tggagccagg gagttcgagg ctgcagtgtc gagatcttgc cactgcactc     2820

cattctggat gatagaacga gaccccatct caaaaaaaaa aaaagttctc tccaattgta     2880

tatagcttgt gattttatgt caacactatc aataaatagc tttcagtgca agaaaccaaa     2940

aatactgtaa taaacaggca catattcttc ccaaacctca tgcagtttac aatctagtga     3000

gagacacaga tagcagtaca gagtcaatta aaggttagtt ttcttcatga agatgtttta     3060

attttaattc aatgtgaaag ggttccaagg agtttatctt gttttatgcc attttatttg     3120

aagcactact tactaagtca tttgctgata ttaatctagt taaatcaaga aatattacat     3180

gaaaatgttg ctaaatcaga gatcatgggt aacaatcacc tttgattatg aataatcata     3240

ttttattgaa aggcaaggca caacaaataa taagaaggaa aaaataaata agcaatgtta     3300

ttgatctttc attctgtata tgttttgggg ggaatatact agtttctttt agtggctgta     3360

acaaattacc acaaacttgg tgacttaaaa tttcacagat ttactctttc ttacagttct     3420

ggaggtcaga agtctgaaat gggtttcaat gcaaggacac acccacagct tacaccattg     3480

gctgctgttt agctccctta tataacactg tcttggggtt taaacgtaac tgaaaatcca     3540

caagacagaa tagccagatc tcagaggagc ctggctaagc aaaaccctgc agaacggctg     3600

cctaatttac agcaaccatg agtacaaatg gtgatgatca tcaggtcaag gatagtctgg     3660

agcaattgag atgtcacttt acatgggagt tatccattga tgacgatgaa atgcctgatt     3720

tagaaaacag agtcttggat cagattgaat tcctagacac caaatacagt gtgggaatac     3780

acaacctact agcctatgtg aaacacctga aaggccagaa tgaggaagcc ctgaagagct     3840

taaaagaagc tgaaaactta atgcaggaag aacatgacaa ccaagcaaat gtgaggagtc     3900

tggtgacctg gggcaacttt gcctggatgt attaccacat gggcagactg gcagaagccc     3960

agacttacct ggacaaggtg gagaacattt gcaagaagct ttcaaatccc ttccgctata     4020

gaatggagtg tccagaaata gactgtgagg aaggatgggc cttgctgaag tgtggaggaa     4080

aaaattatga acgggccaag gcctgctttg aaaaggtgct tgaagtggac cctgaaaacc     4140

ctgaatccag cgctgggtat gcgatctctg cctatcgcct ggatggcttt aaattagcca     4200

caaaaaatca caagccattt tctttgcttc ccctaaggca ggctgtccgc ttaaatccag     4260

acaatggata tattaaggtt ctccttgccc tgaagcttca ggatgaagga caggaagctg     4320

aaggagaaaa gtacattgaa gaagctctag ccaacatgtc ctcacagacc tatgtctttc     4380

gatatgcagc caagttttac cgaagaaaag gctctgtgga taaagctctt gagttattaa     4440

aaaaggcctt gcaggaaaca cccacttctg tcttactgca tcaccagata gggctttgct     4500

acaaggcaca aatgatccaa atcaaggagg ctacaaaagg gcagcctaga gggcagaaca     4560

gagaaaagct agacaaaatg ataagatcag ccatatttca ttttgaatct gcagtggaaa     4620

aaaagcccac atttgaggtg gctcatctag acctggcaag aatgtatata gaagcaggca     4680

atcacagaaa agctgaagag aattttcaaa aattgttatg catgaaacca gtggtagaag     4740

aaacaatgca agacatacat ttccactatg gtcggtttca ggaatttcaa aagaaatctg     4800

acgtcaatgc aattatccat tatttaaaag ctataaaaat agaacaggca tcattaacaa     4860

gggataaaag tatcaattct ttgaagaaat tggttttaag gaaacttcgg agaaaggcat     4920

tagatctgga aagcttgagc ctccttgggt tcgtctacaa attggaagga aatatgaatg     4980

aagccctgga gtactatgag cgggccctga gactggctgc tgactttgag aactctgtga     5040

gacaaggtcc ttaggcaccc agatatcagc cactttcaca tttcatttca ttttatgcta     5100

acatttacta atcatctttt ctgcttactg ttttcagaaa cattataatt cactgtaatg     5160

atgtaattct tgaataataa atctgacaaa atattagttg tgttcaacaa ttagtgaaac     5220

agaatgtgtg tatgcatgta agaaagagaa atcatttgta tgagtgctat gtagtagaga     5280

aaaaatgtta gttaactttg taggaaataa aacattggac ttacactaaa tgtttaattc     5340

attcatttta ttgtgaaata aaaataaaat ccttagctcc tccaccaact gaacagaccc     5400

tcttggccaa ggagacccca gaaaccttaa aaactaagtt tcccaaccat gacaagatga     5460

gagatcattc acacctcatt atattccctc ccttgctaac tgccattgga ctttttccac     5520

tgagttaaac agaaacccat ggaaaacaaa gaacagaaga ctcactcctt ggctgacttc     5580

acctagctca ctccacgtag cgccacagcc agactcccct cccctcttgc ggtttccaca     5640

tgacaactga tcagccttcc ctcctgataa gtgaccactg cccacagact ggttctggcc     5700

agtccatgga ggctgcacac agggtgcctc tatgtccttt gtttcacctt ttgatataga     5760

aaggctaatt ttgctgtatt ttaatgttaa gtctccacca cagagtgaac acagaatgca     5820

tgtgacatac atgtttacat accactattg tgtgactgcc cctcatgaat attcatagcc     5880

ccccataacc tgttaactat gtgtgtctag ccaatccacc aaccataaaa cttctgtaat     5940

accctccctt cctccaagag cctgcttttg gttgctgtgg taggctctgc ttcccaggct     6000

gcaggttgca ggagaggagg ctgcagtggc tcacgcctgt aatctcagca cttcgatggg     6060

acgaggcagg cagatcacct gaacccagga gttcgagagc agccttggca atggcaaaac     6120

caaccgtctc tacaaaaaat gcaaaaactt agctgggtgt ggtggcatgc acctgtagct     6180

tcagttccag ctactcagga ggctgaggtg agtggactgc tggagccagg gagttcgagg     6240

ctgcagtgtc gagatcttgc cactgcactc cattctggat gatagaacga gaccccatct     6300

caaaaaaaaa aaaagttctc tccaattgta tatagcttgt gattttatgt caacactatc     6360

aataaatagc tttcagtgca agaaaccaaa aatactgtaa taaacaggca catattcttc     6420

ccaaacctca tgcagtttac aatctagtga gagacacaga tagcagtaca gagtcaatta     6480

aaggttagtt ttcttcatga agatgtttta attttaattc aatgtgaaag ggttccaagg     6540

agtttatctt gttttatgcc attttatttg aagcactact tactaagtca tttgctgata     6600

ttaatctagt taaatcaaga aatattacat gaaaatgttg ctaaatcaga gatcatgggt     6660

aacaatcacc tttgattatg aataatcata ttttattgaa aggcaaggca caacaaataa     6720

taagaaggaa aaaataaata agcaatgtta ttgatctttc attctgtata tgttttgggg     6780

ggaatatact agtttctttt agtggctgta acaaattacc acaaacttgg tgacttaaaa     6840

tttcacagat ttactctttc ttacagttct ggaggtcaga agtctgaaat gggtttcaat     6900

gagccaaagt caaggtattg atgacgctac actcctccgg aggctctagg cagatagcct     6960

tttccagctt ccagaggctg cctgaattct ttcatccatc ttaaaaacca acagtgtagt     7020

agcctcaaat ctctctctct gcttccttct tcacatctcc ttctctcctc tgactctttg     7080

cctctttctt ctaaggacgc accaggtcca cctgcataat ccagaataat tgccccatcc     7140

gcaaatcctt aatttaataa catctgcaaa gtcccttttg ctatgtaaag tagcatgttc     7200

acaggttctg gagacttggc catggatacg attgcggggg gggcattatt cttaccacag     7260

agcaccccaa gaaaatctcc aaattttggg cttccaatcc attttgcttc aattatttaa     7320

tatttttact ccttccagta gatactgatt tcatccattg cccttaagaa ggtaggacag     7380

agattatggc acatctcaca ttaaatgcta tattttcgtt ggaaatacat tttttgcttc     7440

aacttttatt ttaaattcaa gggtacatgt gcaggatgtt caggtttgtt acacaggtaa     7500

acgtgtgcca tggcggtttg ctgaacagat catcccatca ccaacagatc atcccattga     7560

gaggtgaagc cggctgggct tctgggttgg gtggggactt ggagaacttt tctgtctagc     7620

taaagtattg taaaatggac cagtcaacac tctgtaaaat ggaccaatca gctctctgta     7680

aaatggacca atcagcagga tgtgggtggg gccaagtaag ggaataaaag caggccaccc     7740

gagctggcag cggcaacccg ctcgggtccc cttccatgct gtggaagttt tgttctttcg     7800

ctctttcaat aaatcttgct gctgctcaaa aaaaaaaaaa aaaaa                     7845


<210>  104
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Met Ser Thr Asn Gly Asp Asp His 
            180                 185                 190         


Gln Val Lys Asp Ser Leu Glu Gln Leu Arg Cys His Phe Thr Trp Glu 
        195                 200                 205             


Leu Ser Ile Asp Asp Asp Glu Met Pro Asp Leu Glu Asn Arg Val Leu 
    210                 215                 220                 


Asp Gln Ile Glu Phe Leu Asp Thr Lys Tyr Ser Val Gly Ile His Asn 
225                 230                 235                 240 


Leu Leu Ala Tyr Val Lys His Leu Lys Gly Gln Asn Glu Glu Ala Leu 
                245                 250                 255     


Lys Ser Leu Lys Glu Ala Glu Asn Leu Met Gln Glu Glu His Asp Asn 
            260                 265                 270         


Gln Ala Asn Val Arg Ser Leu Val Thr Trp Gly Asn Phe Ala Trp Met 
        275                 280                 285             


Tyr Tyr His Met Gly Arg Leu Ala Glu Ala Gln Thr Tyr Leu Asp Lys 
    290                 295                 300                 


Val Glu Asn Ile Cys Lys Lys Leu Ser Asn Pro Phe Arg Tyr Arg Met 
305                 310                 315                 320 


Glu Cys Pro Glu Ile Asp Cys Glu Glu Gly Trp Ala Leu Leu Lys Cys 
                325                 330                 335     


Gly Gly Lys Asn Tyr Glu Arg Ala Lys Ala Cys Phe Glu Lys Val Leu 
            340                 345                 350         


Glu Val Asp Pro Glu Asn Pro Glu Ser Ser Ala Gly Tyr Ala Ile Ser 
        355                 360                 365             


Ala Tyr Arg Leu Asp Gly Phe Lys Leu Ala Thr Lys Asn His Lys Pro 
    370                 375                 380                 


Phe Ser Leu Leu Pro Leu Arg Gln Ala Val Arg Leu Asn Pro Asp Asn 
385                 390                 395                 400 


Gly Tyr Ile Lys Val Leu Leu Ala Leu Lys Leu Gln Asp Glu Gly Gln 
                405                 410                 415     


Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu Ala Leu Ala Asn Met Ser 
            420                 425                 430         


Ser Gln Thr Tyr Val Phe Arg Tyr Ala Ala Lys Phe Tyr Arg Arg Lys 
        435                 440                 445             


Gly Ser Val Asp Lys Ala Leu Glu Leu Leu Lys Lys Ala Leu Gln Glu 
    450                 455                 460                 


Thr Pro Thr Ser Val Leu Leu His His Gln Ile Gly Leu Cys Tyr Lys 
465                 470                 475                 480 


Ala Gln Met Ile Gln Ile Lys Glu Ala Thr Lys Gly Gln Pro Arg Gly 
                485                 490                 495     


Gln Asn Arg Glu Lys Leu Asp Lys Met Ile Arg Ser Ala Ile Phe His 
            500                 505                 510         


Phe Glu Ser Ala Val Glu Lys Lys Pro Thr Phe Glu Val Ala His Leu 
        515                 520                 525             


Asp Leu Ala Arg Met Tyr Ile Glu Ala Gly Asn His Arg Lys Ala Glu 
    530                 535                 540                 


Glu Asn Phe Gln Lys Leu Leu Cys Met Lys Pro Val Val Glu Glu Thr 
545                 550                 555                 560 


Met Gln Asp Ile His Phe His Tyr Gly Arg Phe Gln Glu Phe Gln Lys 
                565                 570                 575     


Lys Ser Asp Val Asn Ala Ile Ile His Tyr Leu Lys Ala Ile Lys Ile 
            580                 585                 590         


Glu Gln Ala Ser Leu Thr Arg Asp Lys Ser Ile Asn Ser Leu Lys Lys 
        595                 600                 605             


Leu Val Leu Arg Lys Leu Arg Arg Lys Ala Leu Asp Leu Glu Ser Leu 
    610                 615                 620                 


Ser Leu Leu Gly Phe Val Tyr Lys Leu Glu Gly Asn Met Asn Glu Ala 
625                 630                 635                 640 


Leu Glu Tyr Tyr Glu Arg Ala Leu Arg Leu Ala Ala Asp Phe Glu Asn 
                645                 650                 655     


Ser Val Arg Gln Gly Pro 
            660         


<210>  105
<211>  9878
<212>  DNA
<213>  Homo sapiens

<400>  105
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcgctgag cgcggagccg cccggtgatt      900

ggtgggggcg gaagggggcc gggcgccagc gctgcctttt ctcctgccgg gtagtttcgc      960

tttcctgcgc agagtctgcg gaggggctcg gctgcaccgg ggggatcgcg cctggcagac     1020

cccagaccga gcagaggcga cccagcgcgc tcgggagagg ctgcaccgcc gcgcccccgc     1080

ctagcccttc cggatcctgc gcgcagaaaa gtttcatttg ctgtatgcca tcctcgagag     1140

ctgtctaggt taacgttcgc actctgtgta tataacctcg acagtcttgg cacctaacgt     1200

gctgtgcgta gctgctcctt tggttgaatc cccaggccct tgttggggca caaggtggca     1260

ggatgtctca gtggtacgaa cttcagcagc ttgactcaaa attcctggag caggttcacc     1320

agctttatga tgacagtttt cccatggaaa tcagacagta cctggcacag tggttagaaa     1380

agcaagactg ggagcacgct gccaatgatg tttcatttgc caccatccgt tttcatgacc     1440

tcctgtcaca gctggatgat caatatagtc gcttttcttt ggagaataac ttcttgctac     1500

agcataacat aaggaaaagc aagcgtaatc ttcaggataa ttttcaggaa gacccaatcc     1560

agatgtctat gatcatttac agctgtctga aggaagaaag gaaaattctg gaaaacgccc     1620

agagatttaa tcaggctcag tcggggaata ttcagagcac agtgatgtta gacaaacaga     1680

aagagcttga cagtaaagtc agaaatgtga aggacaaggt tatgtgtata gagcatgaaa     1740

tcaagagcct ggaagattta caagatgaat atgacttcaa atgcaaaacc ttgcagaaca     1800

gagaacacga gaccaatggt gtggcaaaga gtgatcagaa acaagaacag ctgttactca     1860

agaagatgta tttaatgctt gacaataaga gaaaggaagt agttcacaaa ataatagagt     1920

tgctgaatgt cactgaactt acccagaatg ccctgattaa tgatgaacta gtggagtgga     1980

agcggagaca gcagagcgcc tgtattgggg ggccgcccaa tgcttgcttg gatcagctgc     2040

agaactggtt cactatagtt gcggagagtc tgcagcaagt tcggcagcag cttaaaaagt     2100

tggaggaatt ggaacagaaa tacacctacg aacatgaccc tatcacaaaa aacaaacaag     2160

tgttatggga ccgcaccttc agtcttttcc agcagctcat tcagagctcg tttgtggtgg     2220

aaagacagcc ctgcatgcca acgcaccctc agaggccgct ggtcttgaag acaggggtcc     2280

agttcactgt gaagttgaga ctgttggtga aattgcaaga gctgaattat aatttgaaag     2340

tcaaagtctt atttgataaa gatgtgaatg agagaaatac agtaaaagga tttaggaagt     2400

tcaacatttt gggcacgcac acaaaagtga tgaacatgga ggagtccacc aatggcagtc     2460

tggcggctga atttcggcac ctgcaattga aagaacagaa aaatgctggc accagaacga     2520

atgagggtcc tctcatcgtt actgaagagc ttcactccct tagttttgaa acccaattgt     2580

gccagcctgg tttggtaatt gacctcgaga cgacctctct gcccgttgtg gtgatctcca     2640

acgtcagcca gctcccgagc ggttgggcct ccatcctttg gtacaacatg ctggtggcgg     2700

aacccaggaa tctgtccttc ttcctgactc caccatgtgc acgatgggct cagctttcag     2760

aagtgctgag ttggcagttt tcttctgtca ccaaaagagg tctcaatgtg gaccagctga     2820

acatgttggg agagaagctt cttggtccta acgccagccc cgatggtctc attccgtgga     2880

cgaggttttg taaggaaaat ataaatgata aaaattttcc cttctggctt tggattgaaa     2940

gcatcctaga actcattaaa aaacacctgc tccctctctg gaatgatggg tgcatcatgg     3000

gcttcatcag caaggagcga gagcgtgccc tgttgaagga ccagcagccg gggaccttcc     3060

tgctgcggtt cagtgagagc tcccgggaag gggccatcac attcacatgg gtggagcggt     3120

cccagaacgg aggcgaacct gacttccatg cggttgaacc ctacacgaag aaagaacttt     3180

ctgctgttac tttccctgac atcattcgca attacaaagt catggctgct gagaatattc     3240

ctgagaatcc cctgaagtat ctgtatccaa atattgacaa agaccatgcc tttggaaagt     3300

attactccag gccaaaggaa gcaccagagc caatggaact tgatggccct aaaggaactg     3360

gatatatcaa gactgagttg atttctgtgt ctgaagttca cccttctaga cttcagacca     3420

cagacaacct gctccccatg tctcctgagg agtttgacga ggtgtctcgg atagtgggct     3480

ctgtagaatt cgacagtatg atgaacacag tatagagcat gaattttttt catcttctct     3540

ggcgacagtt ttccttctca tctgtgattc cctcctgcta ctctgttcct tcacatcctg     3600

tgtttctagg gaaatgaaag aaaggccagc aaattcgctg caacctgttg atagcaagtg     3660

aatttttctc taactcagaa acatcagtta ctctgaaggg catcatgcat cttactgaag     3720

gtaaaattga aaggcattct ctgaagagtg ggtttcacaa gtgaaaaaca tccagataca     3780

cccaaagtat caggacgaga atgagggtcc tttgggaaag gagaagttaa gcaacatcta     3840

gcaaatgtta tgcataaagt cagtgcccaa ctgttatagg ttgttggata aatcagtggt     3900

tatttaggga actgcttgac gtaggaacgg taaatttctg tgggagaatt cttacatgtt     3960

ttctttgctt taagtgtaac tggcagtttt ccattggttt acctgtgaaa tagttcaaag     4020

ccaagtttat atacaattat atcagtcctc tttcaaaggt agccatcatg gatctggtag     4080

ggggaaaatg tgtattttat tacatctttc acattggcta tttaaagaca aagacaaatt     4140

ctgtttcttg agaagagaat attagcttta ctgtttgtta tggcttaatg acactagcta     4200

atatcaatag aaggatgtac atttccaaat tcacaagttg tgtttgatat ccaaagctga     4260

atacattctg ctttcatctt ggtcacatac aattattttt acagttctcc caagggagtt     4320

aggctattca caaccactca ttcaaaagtt gaaattaacc atagatgtag ataaactcag     4380

aaatttaatt catgtttctt aaatgggcta ctttgtcctt tttgttatta gggtggtatt     4440

tagtctatta gccacaaaat tgggaaagga gtagaaaaag cagtaactga caacttgaat     4500

aatacaccag agataatatg agaatcagat catttcaaaa ctcatttcct atgtaactgc     4560

attgagaact gcatatgttt cgctgatata tgtgtttttc acatttgcga atggttccat     4620

tctctctcct gtactttttc cagacacttt tttgagtgga tgatgtttcg tgaagtatac     4680

tgtattttta cctttttcct tccttatcac tgacacaaaa agtagattaa gagatgggtt     4740

tgacaaggtt cttccctttt acatactgct gtctatgtgg ctgtatcttg tttttccact     4800

actgctacca caactatatt atcatgcaaa tgctgtattc ttctttggtg gagataaaga     4860

tttcttgagt tttgttttaa aattaaagct aaagtatctg tattgcatta aatataatat     4920

gcacacagtg ctttccgtgg cactgcatac aatctgaggc ctcctctctc agtttttata     4980

tagatggcga gaacctaagt ttcagttgat tttacaattg aaatgactaa aaaacaaaga     5040

agacaacatt aaaacaatat tgtttctaat tgctgaggtt tagctgtcag ttctttttgc     5100

cctttgggaa ttcggcatgg tttcatttta ctgcactagc caagagactt tacttttaag     5160

aagtattaaa attctaaaat tcaaaaaaaa aaaaaaaaaa tttccctgac atcattcgca     5220

attacaaagt catggctgct gagaatattc ctgagaatcc cctgaagtat ctgtatccaa     5280

atattgacaa agaccatgcc tttggaaagt attactccag gccaaaggaa gcaccagagc     5340

caatggaact tgatggccct aaaggaactg gatatatcaa gactgagttg atttctgtgt     5400

ctgaagttca cccttctaga cttcagacca cagacaacct gctccccatg tctcctgagg     5460

agtttgacga ggtgtctcgg atagtgggct ctgtagaatt cgacagtatg atgaacacag     5520

tatagagcat gaattttttt catcttctct ggcgacagtt ttccttctca tctgtgattc     5580

cctcctgcta ctctgttcct tcacatcctg tgtttctagg gaaatgaaag aaaggccagc     5640

aaattcgctg caacctgttg atagcaagtg aatttttctc taactcagaa acatcagtta     5700

ctctgaaggg catcatgcat cttactgaag gtaaaattga aaggcattct ctgaagagtg     5760

ggtttcacaa gtgaaaaaca tccagataca cccaaagtat caggacgaga atgagggtcc     5820

tttgggaaag gagaagttaa gcaacatcta gcaaatgtta tgcataaagt cagtgcccaa     5880

ctgttatagg ttgttggata aatcagtggt tatttaggga actgcttgac gtaggaacgg     5940

taaatttctg tgggagaatt cttacatgtt ttctttgctt taagtgtaac tggcagtttt     6000

ccattggttt acctgtgaaa tagttcaaag ccaagtttat atacaattat atcagtcctc     6060

tttcaaaggt agccatcatg gatctggtag ggggaaaatg tgtattttat tacatctttc     6120

acattggcta tttaaagaca aagacaaatt ctgtttcttg agaagagaat attagcttta     6180

ctgtttgtta tggcttaatg acactagcta atatcaatag aaggatgtac atttccaaat     6240

tcacaagttg tgtttgatat ccaaagctga atacattctg ctttcatctt ggtcacatac     6300

aattattttt acagttctcc caagggagtt aggctattca caaccactca ttcaaaagtt     6360

gaaattaacc atagatgtag ataaactcag aaatttaatt catgtttctt aaatgggcta     6420

ctttgtcctt tttgttatta gggtggtatt tagtctatta gccacaaaat tgggaaagga     6480

gtagaaaaag cagtaactga caacttgaat aatacaccag agataatatg agaatcagat     6540

catttcaaaa ctcatttcct atgtaactgc attgagaact gcatatgttt cgctgatata     6600

tgtgtttttc acatttgcga atggttccat tctctctcct gtactttttc cagacacttt     6660

tttgagtgga tgagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag     6720

aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg     6780

gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg     6840

ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa     6900

agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag     6960

ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc     7020

aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc     7080

aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg     7140

gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat     7200

gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc     7260

cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac     7320

gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa     7380

cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa     7440

gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac     7500

atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg     7560

aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc     7620

atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc     7680

ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg     7740

ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc     7800

cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct     7860

gctgttactt tccctgacat cattcgcaat tacaaagtca tggctgctga gaatattcct     7920

gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat     7980

tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga     8040

tatatcaaga ctgagttgat ttctgtgtct gaagttcacc cttctagact tcagaccaca     8100

gacaacctgc tccccatgtc tcctgaggag tttgacgagg tgtctcggat agtgggctct     8160

gtagaattcg acagtatgat gaacacagta tagagcatga atttttttca tcttctctgg     8220

cgacagtttt ccttctcatc tgtgattccc tcctgctact ctgttccttc acatcctgtg     8280

tttctaggga aatgaaagaa aggccagcaa attcgctgca acctgttgat agcaagtgaa     8340

tttttctcta actcagaaac atcagttact ctgaagggca tcatgcatct tactgaaggt     8400

aaaattgaaa ggcattctct gaagagtggg tttcacaagt gaaaaacatc cagatacacc     8460

caaagtatca ggacgagaat gagggtcctt tgggaaagga gaagttaagc aacatctagc     8520

aaatgttatg cataaagtca gtgcccaact gttataggtt gttggataaa tcagtggtta     8580

tttagggaac tgcttgacgt aggaacggta aatttctgtg ggagaattct tacatgtttt     8640

ctttgcttta agtgtaactg gcagttttcc attggtttac ctgtgaaata gttcaaagcc     8700

aagtttatat acaattatat cagtcctctt tcaaaggtag ccatcatgga tctggtaggg     8760

ggaaaatgtg tattttatta catctttcac attggctatt taaagacaaa gacaaattct     8820

gtttcttgag aagagaatat tagctttact gtttgttatg gcttaatgac actagctaat     8880

atcaatagaa ggatgtacat ttccaaattc acaagttgtg tttgatatcc aaagctgaat     8940

acattctgct ttcatcttgg tcacatacaa ttatttttac agttctccca agggagttag     9000

gctattcaca accactcatt caaaagttga aattaaccat agatgtagat aaactcagaa     9060

atttaattca tgtttcttaa atgggctact ttgtcctttt tgttattagg gtggtattta     9120

gtctattagc cacaaaattg ggaaaggagt agaaaaagca gtaactgaca acttgaataa     9180

tacaccagag ataatatgag aatcagatca tttcaaaact catttcctat gtaactgcat     9240

tgagaactgc atatgtttcg ctgatatatg tgtttttcac atttgcgaat ggttccattc     9300

tctctcctgt actttttcca gacacttttt tgagtggatg atgtttcgtg aagtatactg     9360

tatttttacc tttttccttc cttatcactg acacaaaaag tagattaaga gatgggtttg     9420

acaaggttct tcccttttac atactgctgt ctatgtggct gtatcttgtt tttccactac     9480

tgctaccaca actatattat catgcaaatg ctgtattctt ctttggtgga gataaagatt     9540

tcttgagttt tgttttaaaa ttaaagctaa agtatctgta ttgcattaaa tataatatgc     9600

acacagtgct ttccgtggca ctgcatacaa tctgaggcct cctctctcag tttttatata     9660

gatggcgaga acctaagttt cagttgattt tacaattgaa atgactaaaa aacaaagaag     9720

acaacattaa aacaatattg tttctaattg ctgaggttta gctgtcagtt ctttttgccc     9780

tttgggaatt cggcatggtt tcattttact gcactagcca agagacttta cttttaagaa     9840

gtattaaaat tctaaaattc aaaaaaaaaa aaaaaaaa                             9878


<210>  106
<211>  1302
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Met Ser Gln Trp Tyr Glu Leu Gln 
545                 550                 555                 560 


Gln Leu Asp Ser Lys Phe Leu Glu Gln Val His Gln Leu Tyr Asp Asp 
                565                 570                 575     


Ser Phe Pro Met Glu Ile Arg Gln Tyr Leu Ala Gln Trp Leu Glu Lys 
            580                 585                 590         


Gln Asp Trp Glu His Ala Ala Asn Asp Val Ser Phe Ala Thr Ile Arg 
        595                 600                 605             


Phe His Asp Leu Leu Ser Gln Leu Asp Asp Gln Tyr Ser Arg Phe Ser 
    610                 615                 620                 


Leu Glu Asn Asn Phe Leu Leu Gln His Asn Ile Arg Lys Ser Lys Arg 
625                 630                 635                 640 


Asn Leu Gln Asp Asn Phe Gln Glu Asp Pro Ile Gln Met Ser Met Ile 
                645                 650                 655     


Ile Tyr Ser Cys Leu Lys Glu Glu Arg Lys Ile Leu Glu Asn Ala Gln 
            660                 665                 670         


Arg Phe Asn Gln Ala Gln Ser Gly Asn Ile Gln Ser Thr Val Met Leu 
        675                 680                 685             


Asp Lys Gln Lys Glu Leu Asp Ser Lys Val Arg Asn Val Lys Asp Lys 
    690                 695                 700                 


Val Met Cys Ile Glu His Glu Ile Lys Ser Leu Glu Asp Leu Gln Asp 
705                 710                 715                 720 


Glu Tyr Asp Phe Lys Cys Lys Thr Leu Gln Asn Arg Glu His Glu Thr 
                725                 730                 735     


Asn Gly Val Ala Lys Ser Asp Gln Lys Gln Glu Gln Leu Leu Leu Lys 
            740                 745                 750         


Lys Met Tyr Leu Met Leu Asp Asn Lys Arg Lys Glu Val Val His Lys 
        755                 760                 765             


Ile Ile Glu Leu Leu Asn Val Thr Glu Leu Thr Gln Asn Ala Leu Ile 
    770                 775                 780                 


Asn Asp Glu Leu Val Glu Trp Lys Arg Arg Gln Gln Ser Ala Cys Ile 
785                 790                 795                 800 


Gly Gly Pro Pro Asn Ala Cys Leu Asp Gln Leu Gln Asn Trp Phe Thr 
                805                 810                 815     


Ile Val Ala Glu Ser Leu Gln Gln Val Arg Gln Gln Leu Lys Lys Leu 
            820                 825                 830         


Glu Glu Leu Glu Gln Lys Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys 
        835                 840                 845             


Asn Lys Gln Val Leu Trp Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu 
    850                 855                 860                 


Ile Gln Ser Ser Phe Val Val Glu Arg Gln Pro Cys Met Pro Thr His 
865                 870                 875                 880 


Pro Gln Arg Pro Leu Val Leu Lys Thr Gly Val Gln Phe Thr Val Lys 
                885                 890                 895     


Leu Arg Leu Leu Val Lys Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val 
            900                 905                 910         


Lys Val Leu Phe Asp Lys Asp Val Asn Glu Arg Asn Thr Val Lys Gly 
        915                 920                 925             


Phe Arg Lys Phe Asn Ile Leu Gly Thr His Thr Lys Val Met Asn Met 
    930                 935                 940                 


Glu Glu Ser Thr Asn Gly Ser Leu Ala Ala Glu Phe Arg His Leu Gln 
945                 950                 955                 960 


Leu Lys Glu Gln Lys Asn Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu 
                965                 970                 975     


Ile Val Thr Glu Glu Leu His Ser Leu Ser Phe Glu Thr Gln Leu Cys 
            980                 985                 990         


Gln Pro Gly Leu Val Ile Asp Leu  Glu Thr Thr Ser Leu  Pro Val Val 
        995                 1000                 1005             


Val Ile  Ser Asn Val Ser Gln  Leu Pro Ser Gly Trp  Ala Ser Ile 
    1010                 1015                 1020             


Leu Trp  Tyr Asn Met Leu Val  Ala Glu Pro Arg Asn  Leu Ser Phe 
    1025                 1030                 1035             


Phe Leu  Thr Pro Pro Cys Ala  Arg Trp Ala Gln Leu  Ser Glu Val 
    1040                 1045                 1050             


Leu Ser  Trp Gln Phe Ser Ser  Val Thr Lys Arg Gly  Leu Asn Val 
    1055                 1060                 1065             


Asp Gln  Leu Asn Met Leu Gly  Glu Lys Leu Leu Gly  Pro Asn Ala 
    1070                 1075                 1080             


Ser Pro  Asp Gly Leu Ile Pro  Trp Thr Arg Phe Cys  Lys Glu Asn 
    1085                 1090                 1095             


Ile Asn  Asp Lys Asn Phe Pro  Phe Trp Leu Trp Ile  Glu Ser Ile 
    1100                 1105                 1110             


Leu Glu  Leu Ile Lys Lys His  Leu Leu Pro Leu Trp  Asn Asp Gly 
    1115                 1120                 1125             


Cys Ile  Met Gly Phe Ile Ser  Lys Glu Arg Glu Arg  Ala Leu Leu 
    1130                 1135                 1140             


Lys Asp  Gln Gln Pro Gly Thr  Phe Leu Leu Arg Phe  Ser Glu Ser 
    1145                 1150                 1155             


Ser Arg  Glu Gly Ala Ile Thr  Phe Thr Trp Val Glu  Arg Ser Gln 
    1160                 1165                 1170             


Asn Gly  Gly Glu Pro Asp Phe  His Ala Val Glu Pro  Tyr Thr Lys 
    1175                 1180                 1185             


Lys Glu  Leu Ser Ala Val Thr  Phe Pro Asp Ile Ile  Arg Asn Tyr 
    1190                 1195                 1200             


Lys Val  Met Ala Ala Glu Asn  Ile Pro Glu Asn Pro  Leu Lys Tyr 
    1205                 1210                 1215             


Leu Tyr  Pro Asn Ile Asp Lys  Asp His Ala Phe Gly  Lys Tyr Tyr 
    1220                 1225                 1230             


Ser Arg  Pro Lys Glu Ala Pro  Glu Pro Met Glu Leu  Asp Gly Pro 
    1235                 1240                 1245             


Lys Gly  Thr Gly Tyr Ile Lys  Thr Glu Leu Ile Ser  Val Ser Glu 
    1250                 1255                 1260             


Val His  Pro Ser Arg Leu Gln  Thr Thr Asp Asn Leu  Leu Pro Met 
    1265                 1270                 1275             


Ser Pro  Glu Glu Phe Asp Glu  Val Ser Arg Ile Val  Gly Ser Val 
    1280                 1285                 1290             


Glu Phe  Asp Ser Met Met Asn  Thr Val 
    1295                 1300         


<210>  107
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  107
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900

cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960

tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020

ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080

gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140

gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200

gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260

tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320

gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380

gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440

gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500

aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560

catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620

acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680

ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740

ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800

cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860

atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920

aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980

cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040

ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100

tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160

gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220

catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280

tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340

caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atgctgagcg     2400

cggagccgcc cggtgattgg tgggggcgga agggggccgg gcgccagcgc tgccttttct     2460

cctgccgggt agtttcgctt tcctgcgcag agtctgcgga ggggctcggc tgcaccgggg     2520

ggatcgcgcc tggcagaccc cagaccgagc agaggcgacc cagcgcgctc gggagaggct     2580

gcaccgccgc gcccccgcct agcccttccg gatcctgcgc gcagaaaagt ttcatttgct     2640

gtatgccatc ctcgagagct gtctaggtta acgttcgcac tctgtgtata taacctcgac     2700

agtcttggca cctaacgtgc tgtgcgtagc tgctcctttg gttgaatccc caggcccttg     2760

ttggggcaca aggtggcagg atgtctcagt ggtacgaact tcagcagctt gactcaaaat     2820

tcctggagca ggttcaccag ctttatgatg acagttttcc catggaaatc agacagtacc     2880

tggcacagtg gttagaaaag caagactggg agcacgctgc caatgatgtt tcatttgcca     2940

ccatccgttt tcatgacctc ctgtcacagc tggatgatca atatagtcgc ttttctttgg     3000

agaataactt cttgctacag cataacataa ggaaaagcaa gcgtaatctt caggataatt     3060

ttcaggaaga cccaatccag atgtctatga tcatttacag ctgtctgaag gaagaaagga     3120

aaattctgga aaacgcccag agatttaatc aggctcagtc ggggaatatt cagagcacag     3180

tgatgttaga caaacagaaa gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta     3240

tgtgtataga gcatgaaatc aagagcctgg aagatttaca agatgaatat gacttcaaat     3300

gcaaaacctt gcagaacaga gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac     3360

aagaacagct gttactcaag aagatgtatt taatgcttga caataagaga aaggaagtag     3420

ttcacaaaat aatagagttg ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg     3480

atgaactagt ggagtggaag cggagacagc agagcgcctg tattgggggg ccgcccaatg     3540

cttgcttgga tcagctgcag aactggttca ctatagttgc ggagagtctg cagcaagttc     3600

ggcagcagct taaaaagttg gaggaattgg aacagaaata cacctacgaa catgacccta     3660

tcacaaaaaa caaacaagtg ttatgggacc gcaccttcag tcttttccag cagctcattc     3720

agagctcgtt tgtggtggaa agacagccct gcatgccaac gcaccctcag aggccgctgg     3780

tcttgaagac aggggtccag ttcactgtga agttgagact gttggtgaaa ttgcaagagc     3840

tgaattataa tttgaaagtc aaagtcttat ttgataaaga tgtgaatgag agaaatacag     3900

taaaaggatt taggaagttc aacattttgg gcacgcacac aaaagtgatg aacatggagg     3960

agtccaccaa tggcagtctg gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa     4020

atgctggcac cagaacgaat gagggtcctc tcatcgttac tgaagagctt cactccctta     4080

gttttgaaac ccaattgtgc cagcctggtt tggtaattga cctcgagacg acctctctgc     4140

ccgttgtggt gatctccaac gtcagccagc tcccgagcgg ttgggcctcc atcctttggt     4200

acaacatgct ggtggcggaa cccaggaatc tgtccttctt cctgactcca ccatgtgcac     4260

gatgggctca gctttcagaa gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc     4320

tcaatgtgga ccagctgaac atgttgggag agaagcttct tggtcctaac gccagccccg     4380

atggtctcat tccgtggacg aggttttgta aggaaaatat aaatgataaa aattttccct     4440

tctggctttg gattgaaagc atcctagaac tcattaaaaa acacctgctc cctctctgga     4500

atgatgggtg catcatgggc ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc     4560

agcagccggg gaccttcctg ctgcggttca gtgagagctc ccgggaaggg gccatcacat     4620

tcacatgggt ggagcggtcc cagaacggag gcgaacctga cttccatgcg gttgaaccct     4680

acacgaagaa agaactttct gctgttactt tccctgacat cattcgcaat tacaaagtca     4740

tggctgctga gaatattcct gagaatcccc tgaagtatct gtatccaaat attgacaaag     4800

accatgcctt tggaaagtat tactccaggc caaaggaagc accagagcca atggaacttg     4860

atggccctaa aggaactgga tatatcaaga ctgagttgat ttctgtgtct gaagtgtaag     4920

tgaacacaga agagtgacat gtttacaaac ctcaagccag ccttgctcct ggctggggcc     4980

tgttgaagat gcttgtattt tacttttcca ttgtaattgc tatcgccatc acagctgaac     5040

ttgttgagat ccccgtgtta ctgcctatca gcattttact actttaaaaa aaaaaaaaaa     5100

gccaaaaacc aaatttgtat ttaaggtata taaattttcc caaaactgat accctttgaa     5160

aaagtataaa taaaatgagc aaaagttgat                                      5190


<210>  108
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  109
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  109
ctttatcagg gagctgggac tgagtgactg cagccttcct agatcccctc cactcggttt       60

ctctctttgc aggagcaccg gcagcaccag tgtgtgaggg gagcaggcag cggtcctagc      120

cagttccttg atcctgccag accacccagc ccccggcaca gagctgctcc acaggcacca      180

tgaggatcat gctgctattc acagccatcc tggccttcag cctagctcag agctttgggg      240

ctgtctgtaa ggagccacag gaggaggtgg ttcctggcgg gggccgcagc aagagggatc      300

cagatctcta ccagctgctc cagagactct caaaagccac tcatctctgg agggattgct      360

caaagccctg agccaggcta gcacagatcc taaggaatca acatctcccg agaaacactc      420

tcctacggat gtgaatcaag agaacgtccc cagctttggc atcctcaagt atcccccgag      480

agcagaatag gtactccact tccggactcc tggactgcat taggaagacc tctttccctg      540

tcccaatccc caggtgcgca cgctcctgtt accctttctc ttccctgttc ttgtaacatt      600

cttgtgcttt gactccttct ccatcttttc tacctgaccc tggtgtggaa actgcatagt      660

gaatatcccc aaccccaatg ggcattgact gtagaatacc ctagagttcc tgtagtgtcc      720

tacattaaaa atataatgtc tctctctatt cctcaacaat aaaggatttt tgcatatgaa      780

tgaaaa                                                                 786


<210>  110
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Arg Ile Met Leu Leu Phe Thr Ala Ile Leu Ala Phe Ser Leu Ala 
1               5                   10                  15      


Gln Ser Phe Gly Ala Val Cys Lys Glu Pro Gln Glu Glu Val Val Pro 
            20                  25                  30          


Gly Gly Gly Arg Ser Lys Arg Asp Pro Asp Leu Tyr Gln Leu Leu Gln 
        35                  40                  45              


Arg Leu Phe Lys Ser His Ser Ser Leu Glu Gly Leu Leu Lys Ala Leu 
    50                  55                  60                  


Ser Gln Ala Ser Thr Asp Pro Lys Glu Ser Thr Ser Pro Glu Lys His 
65                  70                  75                  80  


Ser Pro Thr Asp Val Asn Gln Glu Asn Val Pro Ser Phe Gly Ile Leu 
                85                  90                  95      


Lys Tyr Pro Pro Arg Ala Glu 
            100             


<210>  111
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  111
ctttatcagg gagctgggac tgagtgactg cagccttcct agatcccctc cactcggttt       60

ctctctttgc aggagcaccg gcagcaccag tgtgtgaggg gagcaggcag cggtcctagc      120

cagttccttg atcctgccag accacccagc ccccggcaca gagctgctcc acaggcacca      180

tgaggatcat gctgctattc acagccatcc tggccttcag cctagctcag agctttgggg      240

ctgtctgtaa ggagccacag gaggaggtgg ttcctggcgg gggccgcagc aagagggatc      300

cagatctcta ccagctgctc cagagactct tcaaaagcca ctcatctctg gagggattgc      360

tcaaagccct gagccaggct agcacagatc ctaaggaatc aacatctccc gagaaacgtg      420

acatgcatga cttctttgtg ggacttatgg gcaagaggag cgtccagcca gactctccta      480

cggatgtgaa tcaagagaac gtccccagct ttggcatcct caagtatccc ccgagagcag      540

aataggtact ccacttccgg actcctggac tgcattagga agacctcttt ccctgtccca      600

atccccaggt gcgcacgctc ctgttaccct ttctcttccc tgttcttgta acattcttgt      660

gctttgactc cttctccatc ttttctacct gaccctggtg tggaaactgc atagtgaata      720

tccccaaccc caatgggcat tgactgtaga ataccctaga gttcctgtag tgtcctacat      780

taaaaatata atgtctctct ctattcctca acaataaagg atttttgcat tgaatgaaaa      840


<210>  112
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Arg Ile Met Leu Leu Phe Thr Ala Ile Leu Ala Phe Ser Leu Ala 
1               5                   10                  15      


Gln Ser Phe Gly Ala Val Cys Lys Glu Pro Gln Glu Glu Val Val Pro 
            20                  25                  30          


Gly Gly Gly Arg Ser Lys Arg Asp Pro Asp Leu Tyr Gln Leu Leu Gln 
        35                  40                  45              


Arg Leu Phe Lys Ser His Ser Ser Leu Glu Gly Leu Leu Lys Ala Leu 
    50                  55                  60                  


Ser Gln Ala Ser Thr Asp Pro Lys Glu Ser Thr Ser Pro Glu Lys Arg 
65                  70                  75                  80  


Asp Met His Asp Phe Phe Val Gly Leu Met Gly Lys Arg Ser Val Gln 
                85                  90                  95      


Pro Asp Ser Pro Thr Asp Val Asn Gln Glu Asn Val Pro Ser Phe Gly 
            100                 105                 110         


Ile Leu Lys Tyr Pro Pro Arg Ala Glu 
        115                 120     


<210>  113
<211>  4629
<212>  DNA
<213>  Homo sapiens

<400>  113
ggggctgagg gtggagagag gaagggaagg aagaaaaggg gagccttcct ggccagggta       60

accggcacta agaggcctca ctccaagccc ccgaggagcc tgtggtgggg ctggaggggg      120

ctgagggtgg agagaggaag ggaaggaaga aaaggggagc cttcctggcc agggtaaccg      180

gcactaagag gcctcactcc aagcccccga ggagcctgtg gtggggctgg agacccggct      240

caggcccctc caccaccctt aaagtcctca gaaggtggga actgaactgg cacaggatgg      300

gaaccggctg tgcgctggcc acttgatttt gccagctgcc ctgtaattca gctggtgagg      360

aaactgaggc acagactgag gtagaatgat tcgccagtca ctcagcaagt cagcagacgg      420

ggaggactga atcccagcct gagagcccga agcttgtatc cctgcaatac cgagccccaa      480

gcctgcgagc cccggtgccc atctctgagt taggccgtct tggaagggtt cccttcctcc      540

tacaagatgg tgtgtgagga gccttcaata cgacccgggg tgtaaagtgt ccaactctag      600

taggggcctg atggcatccc cgccgagtcc caggagagag agagaagacc ccttcctgga      660

gtccagggct cccgggaaga aacactggca tttgtccctt tgcttcggct tctggaggca      720

gagactctga gcccagggag agccttctgc agccccattt cctcaaaaat ccaacctgcc      780

caggtggcgg gtcatgagct gtgctcagga agctggaatc tgaccctggt ggcgtcgggc      840

ccagtctcca tggcagccga gcatttatta cccgggcctc cacccagctt ggcagacttt      900

agacttgagg ctggaggaaa gggaactgaa cgcggttctg ggagcagcaa gcccacgggt      960

agcagccgag gccccagaat ggccaagttt ctttcccaag accaaattaa tgacggaaat     1020

ggagagctgg atttctccac ttttctgacc attatgcaca tgcaaataaa acaagaagac     1080

ccaaagaaag aaattcttct agccatgttg atggtggaca aggagaagaa aggttacgtc     1140

atggcgtccg acctgcggtc aaaactcacg agtctggggg agaagctcac ccacaaggaa     1200

gtggatgatc tcttcaggga agcagatatc gaacccaatg gcaaagtgaa gtatgatgaa     1260

tttatccaca agatcaccct tcctggacgg gactattgaa ggaggagaat gggagagcct     1320

cccctgggcc tgaaaacttg gagcaattaa ttttttttaa aaagtgttct tttcacttgg     1380

gagagatggc aaacacagtg gcaagacaac attacccaac tatagaagag aggctaacta     1440

gcaacaataa tagatgattt cagccatggt atgagtagat ctttaataaa agatttgtat     1500

tgattttatt aactaccgtg agtccggccc tttcaagcat ggaaggagcc tgcggtttgg     1560

agtctggcct gggttccagt cctggctctg ctgcttccca ctgtgacttt gggcaaatca     1620

tttcactcct caaagccccc ccacacaagc tggattccca cttcttacct catggagcct     1680

gttgaggaag gattgagctg atgacttaag ggcaatctac caagagactt attctgtatt     1740

tgggggctag aaccatcttc catatttcca agattttcca agatgaagcc agtgctagct     1800

gagaagcagc aatgaacaga aagctgtaac acttatgaca acaattcttg cagtgccaga     1860

ggcccattta caaattctca tttccatctc aacagatata gtgacatagc tcaggctatt     1920

cattcataaa cacagagtgt agagtgaaaa cactagagtg aaaacacatg ctacaatgag     1980

gcagcatcag ctgagagcag gaagagcgat ctactttaca ccccacacca aaggaaacca     2040

gatgtgagct gctaaattga ctggccttgc agagctcaag aagggggctt ccaatgctgt     2100

gagaattccg agctgttccc tgggctctgt taacaggcag agaggttccg ggatggtctg     2160

ctcaagtggc ccacactggt cattgcctta agccacctcc ccaggactta cggagagaaa     2220

taaggggatg taaccagcaa tggccagggt acaacagccc tggaaaacag tagtaggagc     2280

actaggcttt ctgggagtcc atccagctgg agtggctttg agtgagttac acagctagaa     2340

ggtgccaggt tggtgctgcc agagattcag aggtgccata cacttgtcaa atctggatca     2400

ttcgtagtgc cagcacagtc ctaaaagggc tggagtacca caccaacaca ggtaggggtg     2460

cagggcttca agtacaaaga tttgcatcca tgtatgtatc aaaagtgggt tctctgggct     2520

gtggctttgt ctagtagtac cacagtggct aaagtagaag aaaaccaaat caaatgggat     2580

gtgtcttttg ggaggatgta caagacacaa atctttcact aggcaccggg cacagggaaa     2640

actgcaggga acaagagttg tagtgttagt gcaactgtct caacgatgct gtgtggcttc     2700

agacccaaac aaggccctga ggaaggagac tctcatttcc ccaagcataa ctgcaaggag     2760

aggaggaatt cctaggagcc aaagagtttt gtggggtgag ggtaaataaa tggcccaaat     2820

gccaactagg tgaagttgtg accatctggc tgggaagccc aggtccacac agtgtaggag     2880

cagatgtttt gtggggtctg aggtttacga gatttggctg ccttaagaat acaaaaacag     2940

aaatgcagaa tttctggggc tgctcctagg accagaacaa gtgaagggtc ctggtgctta     3000

aacttcatta ccttcatggt aaatccacca gagggccggt tagatgctgg ccccgccgag     3060

agaactgctg tcactttcag gcaaagctca aaggtcctag gcccacagtt cttttgagct     3120

ccagtcatgg acattaggaa gtaaatcctg cacagccaac ctggaatacc aaagattaga     3180

tgggagatag ataccaatga tttagatggc acaggaagag caagttctgg atataataaa     3240

tgagggtact ttccgtcaaa gcttttctat gtctatattt atcactgaat agtcccagta     3300

tggttttaaa gcaagtttta tgaatctcat ttgcctaaca ggaatctgaa atataacttg     3360

ccaaaaacac acagttggtg tggaatggtc attagaacct ggggctcctc ttcacggact     3420

ccctgctcat taagggattc agtggtccag agtctaagat cctattaagt gtttgattca     3480

aacctctacc cgaggaaggg ctgttacctt actcctggtc ctggtttcaa gctcattcct     3540

gaaattccag ctggtttctc tagcacctag tgttgtttac aagaaggcca cggtgctctt     3600

agcattcaaa ctgcagatac taaacagatg ctgtgattta ttaaagagtt agccatattt     3660

caacaagaaa gggaaatgat ggctatattc attacttacc tcaaagcatg ctgcaagaaa     3720

attagttagt tacttgtcat gctttgaaat ctctggatga aaggtgcttt ggaagcacaa     3780

accattatca cttgtctcat agggattgtc cccttgaaca tccagcagtg ttattttaca     3840

gaagacaaat taactgaagg cttttctttt attacatcta aagagctcta cataaacagg     3900

taacattcaa taggtaaaca atttttttcc aatgcatgta ataaatattt tcacttggta     3960

cttttataca aactgacatt gtctactata catttttaaa agccatttta ctggtttggc     4020

atgcggtatg gaaattctaa gagagaaagt tttaaggcaa tgaatcacag atttaagttc     4080

atggaattta tggtaacttt atctgtttat gtacattttc ccctttgtta aacaattaac     4140

agcagcacac tctgggacca ccagctattt tccctctctt tctgaaatct aagctttgta     4200

tttaattaaa aaacagaatt caacatctat tgataaaaca aaattcttac taaaataatt     4260

tcaaatgtgc tttaaaaagt cctgaagatc ttgaaagttt tatgtgttta aaattgaaat     4320

tgtctaaaaa aatgctcttt ccacattaat ttagttagga tatattttca ctccatttca     4380

gacacttgac tcaaaggaaa atctgccaaa gaatccgatt tttcagagct tacgtgaatc     4440

tttcctcagt aaagatacag aattgtgatc atgtctaaat aattagtaaa gcaattttaa     4500

tgctcaaaat agtcaaccaa gtatggcatg gttctggttc agattttttt tttttaagat     4560

gtatccaata acactcacga agtaattaaa agccacttta accctgctaa aaaaaaaaaa     4620

aaaaaaaaa                                                             4629


<210>  114
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ala Glu His Leu Leu Pro Gly Pro Pro Pro Ser Leu Ala Asp 
1               5                   10                  15      


Phe Arg Leu Glu Ala Gly Gly Lys Gly Thr Glu Arg Gly Ser Gly Ser 
            20                  25                  30          


Ser Lys Pro Thr Gly Ser Ser Arg Gly Pro Arg Met Ala Lys Phe Leu 
        35                  40                  45              


Ser Gln Asp Gln Ile Asn Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr 
    50                  55                  60                  


Phe Leu Thr Ile Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys 
65                  70                  75                  80  


Glu Ile Leu Leu Ala Met Leu Met Val Asp Lys Glu Lys Lys Gly Tyr 
                85                  90                  95      


Val Met Ala Ser Asp Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys 
            100                 105                 110         


Leu Thr His Lys Glu Val Asp Asp Leu Phe Arg Glu Ala Asp Ile Glu 
        115                 120                 125             


Pro Asn Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys Ile Thr Leu 
    130                 135                 140                 


Pro Gly Arg Asp Tyr 
145                 


<210>  115
<211>  4624
<212>  DNA
<213>  Homo sapiens

<400>  115
ggggctgagg gtggagagag gaagggaagg aagaaaaggg gagccttcct ggccagggta       60

accggcacta agaggcctca ctccaagccc ccgaggagcc tgtggtgggg ctggagaccc      120

ggctcaggcc cctccaccac ccttaaagtc ctcagaaggt gggaactgaa ctggcacagg      180

atgggaaccg gctgtgcgct ggccacttga ttttgccagc tgccctgtaa ttcagctggt      240

gaggaaactg aggcacagac tgaggtagaa tgattcgcca gtcactcagc aagtcagcag      300

acggggagga ctgaatccca gcctgagagc accgaagctt gtatccctgc aataccgagc      360

cccaagcctg cgagccccgg tgcccatctc tgagttaggc cgtcttggaa gggttccctt      420

cctcctacaa gatggtgtgt gaggagcctt caatacgacc cggggtgtaa agtgtccaac      480

tctagtaggg gcctgatggc atccccgccg agtcccagga gagagagaga agaccccttc      540

ctggagtcca gggctcccgg gaagaaacac tggcatttgt ccctttgctt cggcttctgg      600

aggcagagac tctgagccca gggagagcct tctgcagccc catttcctca aaaatccaac      660

ctgcccaggt ggcgggtcat gagctgtgct caggaagctg gaatctgacc ctggtggcgt      720

cgggcccagt ctccatggca gccgagcatt tattacccgg gcctccaccc agcttggcag      780

actttagact tgaggctgga ggaaagggaa ctgaacgcgg ttctgggagc agcaagccca      840

cgggtagcag ccgaggcccc agaatgagta caaggaatgc ttctccctgt atgacaagca      900

gcagaggggg aagataaaag ccaccgacct catggtggcc atgaggtgcc tgggggccag      960

cccgacgcca ggggaggtgc agcggcacct gcagacccac gggatagacg gaaatggaga     1020

gctggatttc tccacttttc tgaccattat gcacatgcaa ataaaacaag aagacccaaa     1080

gaaagaaatt cttctagcca tgttgatggt ggacaaggag aagaaaggtt acgtcatggc     1140

gtccgacctg cggtcaaaac tcacgagtct gggggagaag ctcacccaca aggaagtgga     1200

tgatctcttc agggaagcag atatcgaacc caatggcaaa gtgaagtatg atgaatttat     1260

ccacaagatc acccttcctg gacgggacta ttgaaggagg agaatgggag agcctcccct     1320

gggcctgaaa acttggagca attaattttt tttaaaaagt gttcttttca cttgggagag     1380

atggcaaaca cagtggcaag acaacattac ccaactatag aagagaggct aactagcaac     1440

aataatagat gatttcagcc atggtatgag tagatcttta ataaaagatt tgtattgatt     1500

ttattaacta ccgtgagtcc ggccctttca agcatggaag gagcctgcgg tttggagtct     1560

ggcctgggtt ccagtcctgg ctctgctgct tcccactgtg actttgggca aatcatttca     1620

ctcctcaaag cccccccaca caagctggat tcccacttct tacctcatgg agcctgttga     1680

ggaaggattg agctgatgac ttaagggcaa tctaccaaga gacttattct gtatttgggg     1740

gctagaacca tcttccatat ttccaagatt ttccaagatg aagccagtgc tagctgagaa     1800

gcagcaatga acagaaagct gtaacactta tgacaacaat tcttgcagtg ccagaggccc     1860

atttacaaat tctcatttcc atctcaacag atatagtgac atagctcagg ctattcattc     1920

ataaacacag agtgtagagt gaaaacacta gagtgaaaac acatgctaca atgaggcagc     1980

atcagctgag agcaggaaga gcgatctact ttacacccca caccaaagga aaccagatgt     2040

gagctgctaa attgactggc cttgcagagc tcaagaaggg ggcttccaat gctgtgagaa     2100

ttccgagctg ttccctgggc tctgttaaca ggcagagagg ttccgggatg gtctgctcaa     2160

gtggcccaca ctggtcattg ccttaagcca cctccccagg acttacggag agaaataagg     2220

ggatgtaacc agcaatggcc agggtacaac agccctggaa aacagtagta ggagcactag     2280

gctttctggg agtccatcca gctggagtgg ctttgagtga gttacacagc tagaaggtgc     2340

caggttggtg ctgccagaga ttcagaggtg ccatacactt gtcaaatctg gatcattcgt     2400

agtgccagca cagtcctaaa agggctggag taccacacca acacaggtag gggtgcaggg     2460

cttcaagtac aaagatttgc atccatgtat gtatcaaaag tgggttctct gggctgtggc     2520

tttgtctagt agtaccacag tggctaaagt agaagaaaac caaatcaaat gggatgtgtc     2580

ttttgggagg atgtacaaga cacaaatctt tcactaggca ccgggcacag ggaaaactgc     2640

agggaacaag agttgtagtg ttagtgcaac tgtctcaacg atgctgtgtg gcttcagacc     2700

caaacaaggc cctgaggaag gagactctca tttccccaag cataactgca aggagaggag     2760

gaattcctag gagccaaaga gttttgtggg gtgagggtaa ataaatggcc caaatgccaa     2820

ctaggtgaag ttgtgaccat ctggctggga agcccaggtc cacacagtgt aggagcagat     2880

gttttgtggg gtctgaggtt tacgagattt ggctgcctta agaatacaaa aacagaaatg     2940

cagaatttct ggggctgctc ctaggaccag aacaagtgaa gggtcctggt gcttaaactt     3000

cattaccttc atggtaaatc caccagaggg ccggttagat gctggccccg ccgagagaac     3060

tgctgtcact ttcaggcaaa gctcaaaggt cctaggccca cagttctttt gagctccagt     3120

catggacatt aggaagtaaa tcctgcacag ccaacctgga ataccaaaga ttagatggga     3180

gatagatacc aatgatttag atggcacagg aagagcaagt tctggatata ataaatgagg     3240

gtactttccg tcaaagcttt tctatgtcta tatttatcac tgaatagtcc cagtatggtt     3300

ttaaagcaag ttttatgaat ctcatttgcc taacaggaat ctgaaatata acttgccaaa     3360

aacacacagt tggtgtggaa tggtcattag aacctggggc tcctcttcac ggactccctg     3420

ctcattaagg gattcagtgg tccagagtct aagatcctat taagtgtttg attcaaacct     3480

ctacccgagg aagggctgtt accttactcc tggtcctggt ttcaagctca ttcctgaaat     3540

tccagctggt ttctctagca cctagtgttg tttacaagaa ggccacggtg ctcttagcat     3600

tcaaactgca gatactaaac agatgctgtg atttattaaa gagttagcca tatttcaaca     3660

agaaagggaa atgatggcta tattcattac ttacctcaaa gcatgctgca agaaaattag     3720

ttagttactt gtcatgcttt gaaatctctg gatgaaaggt gctttggaag cacaaaccat     3780

tatcacttgt ctcataggga ttgtcccctt gaacatccag cagtgttatt ttacagaaga     3840

caaattaact gaaggctttt cttttattac atctaaagag ctctacataa acaggtaaca     3900

ttcaataggt aaacaatttt tttccaatgc atgtaataaa tattttcact tggtactttt     3960

atacaaactg acattgtcta ctatacattt ttaaaagcca ttttactggt ttggcatgcg     4020

gtatggaaat tctaagagag aaagttttaa ggcaatgaat cacagattta agttcatgga     4080

atttatggta actttatctg tttatgtaca ttttcccctt tgttaaacaa ttaacagcag     4140

cacactctgg gaccaccagc tattttccct ctctttctga aatctaagct ttgtatttaa     4200

ttaaaaaaca gaattcaaca tctattgata aaacaaaatt cttactaaaa taatttcaaa     4260

tgtgctttaa aaagtcctga agatcttgaa agttttatgt gtttaaaatt gaaattgtct     4320

aaaaaaatgc tctttccaca ttaatttagt taggatatat tttcactcca tttcagacac     4380

ttgactcaaa ggaaaatctg ccaaagaatc cgatttttca gagcttacgt gaatctttcc     4440

tcagtaaaga tacagaattg tgatcatgtc taaataatta gtaaagcaat tttaatgctc     4500

aaaatagtca accaagtatg gcatggttct ggttcagatt tttttttttt aagatgtatc     4560

caataacact cacgaagtaa ttaaaagcca ctttaaccct gctaaaaaaa aaaaaaaaaa     4620

aaaa                                                                  4624


<210>  116
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Val Ala Met Arg Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu Val 
1               5                   10                  15      


Gln Arg His Leu Gln Thr His Gly Ile Asp Gly Asn Gly Glu Leu Asp 
            20                  25                  30          


Phe Ser Thr Phe Leu Thr Ile Met His Met Gln Ile Lys Gln Glu Asp 
        35                  40                  45              


Pro Lys Lys Glu Ile Leu Leu Ala Met Leu Met Val Asp Lys Glu Lys 
    50                  55                  60                  


Lys Gly Tyr Val Met Ala Ser Asp Leu Arg Ser Lys Leu Thr Ser Leu 
65                  70                  75                  80  


Gly Glu Lys Leu Thr His Lys Glu Val Asp Asp Leu Phe Arg Glu Ala 
                85                  90                  95      


Asp Ile Glu Pro Asn Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys 
            100                 105                 110         


Ile Thr Leu Pro Gly Arg Asp Tyr 
        115                 120 


<210>  117
<211>  4483
<212>  DNA
<213>  Homo sapiens

<400>  117
ggggctgagg gtggagagag gaagggaagg aagaaaaggg gagccttcct ggccagggta       60

accggcacta agaggcctca ctccaagccc ccgaggagcc tgtggtgggg ctggagaccc      120

ggctcaggcc cctccaccac ccttaaagtc ctcagaaggt gggaactgaa ctggcacagg      180

atgggaaccg gctgtgcgct ggccacttga ttttgccagc tgccctgtaa ttcagctggt      240

gaggaaactg aggcacagac tgaggtagaa tgattcgcca gtcactcagc aagtcagcag      300

acggggagga ctgaatccca gcctgagagc accgaagctt gtatccctgc aataccgagc      360

cccaagcctg cgagccccgg tgcccatctc tgagttaggc cgtcttggaa gggttccctt      420

cctcctacaa gatggtgtgt gaggagcctt caatacgacc cggggtgtaa agtgtccaac      480

tctagtaggg gcctgatggc atccccgccg agtcccagga gagagagaga agaccccttc      540

ctggagtcca gggctcccgg gaagaaacac tggcatttgt ccctttgctt cggcttctgg      600

aggcagagac tctgagccca gggagagcct tctgcagccc catttcctca aaaatccaac      660

ctgcccaggt ggcgggtcat gagctgtgct caggaagctg gaatctgacc ctggtggcgt      720

cgggcccagt ctccatggca gccgagcatt tattacccgg gcctccaccc agcttggcag      780

actttagact tgaggctgga ggaaagggaa ctgaacgcgg ttctgggagc agcaagccca      840

cgggtagcag ccgaggcccc agaatgacgg aaatggagag ctggatttct ccacttttct      900

gaccattatg cacatgcaaa taaaacaaga agacccaaag aaagaaattc ttctagccat      960

gttgatggtg gacaaggaga agaaaggtta cgtcatggcg tccgacctgc ggtcaaaact     1020

cacgagtctg ggggagaagc tcacccacaa ggaagtggat gatctcttca gggaagcaga     1080

tatcgaaccc aatggcaaag tgaagtatga tgaatttatc cacaagatca cccttcctgg     1140

acgggactat tgaaggagga gaatgggaga gcctcccctg ggcctgaaaa cttggagcaa     1200

ttaatttttt ttaaaaagtg ttcttttcac ttgggagaga tggcaaacac agtggcaaga     1260

caacattacc caactataga agagaggcta actagcaaca ataatagatg atttcagcca     1320

tggtatgagt agatctttaa taaaagattt gtattgattt tattaactac cgtgagtccg     1380

gccctttcaa gcatggaagg agcctgcggt ttggagtctg gcctgggttc cagtcctggc     1440

tctgctgctt cccactgtga ctttgggcaa atcatttcac tcctcaaagc ccccccacac     1500

aagctggatt cccacttctt acctcatgga gcctgttgag gaaggattga gctgatgact     1560

taagggcaat ctaccaagag acttattctg tatttggggg ctagaaccat cttccatatt     1620

tccaagattt tccaagatga agccagtgct agctgagaag cagcaatgaa cagaaagctg     1680

taacacttat gacaacaatt cttgcagtgc cagaggccca tttacaaatt ctcatttcca     1740

tctcaacaga tatagtgaca tagctcaggc tattcattca taaacacaga gtgtagagtg     1800

aaaacactag agtgaaaaca catgctacaa tgaggcagca tcagctgaga gcaggaagag     1860

cgatctactt tacaccccac accaaaggaa accagatgtg agctgctaaa ttgactggcc     1920

ttgcagagct caagaagggg gcttccaatg ctgtgagaat tccgagctgt tccctgggct     1980

ctgttaacag gcagagaggt tccgggatgg tctgctcaag tggcccacac tggtcattgc     2040

cttaagccac ctccccagga cttacggaga gaaataaggg gatgtaacca gcaatggcca     2100

gggtacaaca gccctggaaa acagtagtag gagcactagg ctttctggga gtccatccag     2160

ctggagtggc tttgagtgag ttacacagct agaaggtgcc aggttggtgc tgccagagat     2220

tcagaggtgc catacacttg tcaaatctgg atcattcgta gtgccagcac agtcctaaaa     2280

gggctggagt accacaccaa cacaggtagg ggtgcagggc ttcaagtaca aagatttgca     2340

tccatgtatg tatcaaaagt gggttctctg ggctgtggct ttgtctagta gtaccacagt     2400

ggctaaagta gaagaaaacc aaatcaaatg ggatgtgtct tttgggagga tgtacaagac     2460

acaaatcttt cactaggcac cgggcacagg gaaaactgca gggaacaaga gttgtagtgt     2520

tagtgcaact gtctcaacga tgctgtgtgg cttcagaccc aaacaaggcc ctgaggaagg     2580

agactctcat ttccccaagc ataactgcaa ggagaggagg aattcctagg agccaaagag     2640

ttttgtgggg tgagggtaaa taaatggccc aaatgccaac taggtgaagt tgtgaccatc     2700

tggctgggaa gcccaggtcc acacagtgta ggagcagatg ttttgtgggg tctgaggttt     2760

acgagatttg gctgccttaa gaatacaaaa acagaaatgc agaatttctg gggctgctcc     2820

taggaccaga acaagtgaag ggtcctggtg cttaaacttc attaccttca tggtaaatcc     2880

accagagggc cggttagatg ctggccccgc cgagagaact gctgtcactt tcaggcaaag     2940

ctcaaaggtc ctaggcccac agttcttttg agctccagtc atggacatta ggaagtaaat     3000

cctgcacagc caacctggaa taccaaagat tagatgggag atagatacca atgatttaga     3060

tggcacagga agagcaagtt ctggatataa taaatgaggg tactttccgt caaagctttt     3120

ctatgtctat atttatcact gaatagtccc agtatggttt taaagcaagt tttatgaatc     3180

tcatttgcct aacaggaatc tgaaatataa cttgccaaaa acacacagtt ggtgtggaat     3240

ggtcattaga acctggggct cctcttcacg gactccctgc tcattaaggg attcagtggt     3300

ccagagtcta agatcctatt aagtgtttga ttcaaacctc tacccgagga agggctgtta     3360

ccttactcct ggtcctggtt tcaagctcat tcctgaaatt ccagctggtt tctctagcac     3420

ctagtgttgt ttacaagaag gccacggtgc tcttagcatt caaactgcag atactaaaca     3480

gatgctgtga tttattaaag agttagccat atttcaacaa gaaagggaaa tgatggctat     3540

attcattact tacctcaaag catgctgcaa gaaaattagt tagttacttg tcatgctttg     3600

aaatctctgg atgaaaggtg ctttggaagc acaaaccatt atcacttgtc tcatagggat     3660

tgtccccttg aacatccagc agtgttattt tacagaagac aaattaactg aaggcttttc     3720

ttttattaca tctaaagagc tctacataaa caggtaacat tcaataggta aacaattttt     3780

ttccaatgca tgtaataaat attttcactt ggtactttta tacaaactga cattgtctac     3840

tatacatttt taaaagccat tttactggtt tggcatgcgg tatggaaatt ctaagagaga     3900

aagttttaag gcaatgaatc acagatttaa gttcatggaa tttatggtaa ctttatctgt     3960

ttatgtacat tttccccttt gttaaacaat taacagcagc acactctggg accaccagct     4020

attttccctc tctttctgaa atctaagctt tgtatttaat taaaaaacag aattcaacat     4080

ctattgataa aacaaaattc ttactaaaat aatttcaaat gtgctttaaa aagtcctgaa     4140

gatcttgaaa gttttatgtg tttaaaattg aaattgtcta aaaaaatgct ctttccacat     4200

taatttagtt aggatatatt ttcactccat ttcagacact tgactcaaag gaaaatctgc     4260

caaagaatcc gatttttcag agcttacgtg aatctttcct cagtaaagat acagaattgt     4320

gatcatgtct aaataattag taaagcaatt ttaatgctca aaatagtcaa ccaagtatgg     4380

catggttctg gttcagattt ttttttttta agatgtatcc aataacactc acgaagtaat     4440

taaaagccac tttaaccctg ctaaaaaaaa aaaaaaaaaa aaa                       4483


<210>  118
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  118

Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys Glu Ile Leu Leu 
1               5                   10                  15      


Ala Met Leu Met Val Asp Lys Glu Lys Lys Gly Tyr Val Met Ala Ser 
            20                  25                  30          


Asp Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys Leu Thr His Lys 
        35                  40                  45              


Glu Val Asp Asp Leu Phe Arg Glu Ala Asp Ile Glu Pro Asn Gly Lys 
    50                  55                  60                  


Val Lys Tyr Asp Glu Phe Ile His Lys Ile Thr Leu Pro Gly Arg Asp 
65                  70                  75                  80  


Tyr 
    


<210>  119
<211>  4655
<212>  DNA
<213>  Homo sapiens

<400>  119
ggggctgagg gtggagagag gaagggaagg aagaaaaggg gagccttcct ggccagggta       60

accggcacta agaggcctca ctccaagccc ccgaggagcc tgtggtgggg ctggagaccc      120

ggctcaggcc cctccaccac ccttaaagtc ctcagaaggt gggaactgaa ctggcacagg      180

atgggaaccg gctgtgcgct ggccacttga ttttgccagc tgccctgtaa ttcagctggt      240

gaggaaactg aggcacagac tgaggtagaa tgattcgcca gtcactcagc aagtcagcag      300

acggggagga ctgaatccca gcctgagagc accgaagctt gtatccctgc aataccgagc      360

cccaagcctg cgagccccgg tgcccatctc tgagttaggc cgtcttggaa gggttccctt      420

cctcctacaa gatggtgtgt gaggagcctt caatacgacc cggggtgtaa agtgtccaac      480

tctagtaggg gcctgatggc atccccgccg agtcccagga gagagagaga agaccccttc      540

ctggagtcca gggctcccgg gaagaaacac tggcatttgt ccctttgctt cggcttctgg      600

aggcagagac tctgagccca gggagagcct tctgcagccc catttcctca aaaatccaac      660

ctgcccaggt ggcgggtcat gagctgtgct caggaagctg gaatctgacc ctggtggcgt      720

cgggcccagt ctccatggca gccgagcatt tattacccgg gcctccaccc agcttggcag      780

actttagact tgaggctgga ggaaagggaa ctgaacgcgg ttctgggagc agcaagccca      840

cgggtagcag ccgaggcccc agaatggcca agtttctttc ccaagaccaa attaatgagt      900

acaaggaatg cttctccctg tatgacaagc agcagagggg gaagataaaa gccaccgacc      960

tcatggtggc catgaggtgc ctgggggcca gcccgacgcc aggggaggtg cagcggcacc     1020

tgcagaccca cgggatagac ggaaatggag agctggattt ctccactttt ctgaccatta     1080

tgcacatgca aataaaacaa gaagacccaa agaaagaaat tcttctagcc atgttgatgg     1140

tggacaagga gaagaaaggt tacgtcatgg cgtccgacct gcggtcaaaa ctcacgagtc     1200

tgggggagaa gctcacccac aaggaagtgg atgatctctt cagggaagca gatatcgaac     1260

ccaatggcaa agtgaagtat gatgaattta tccacaagat cacccttcct ggacgggact     1320

attgaaggag gagaatggga gagcctcccc tgggcctgaa aacttggagc aattaatttt     1380

ttttaaaaag tgttcttttc acttgggaga gatggcaaac acagtggcaa gacaacatta     1440

cccaactata gaagagaggc taactagcaa caataataga tgatttcagc catggtatga     1500

gtagatcttt aataaaagat ttgtattgat tttattaact accgtgagtc cggccctttc     1560

aagcatggaa ggagcctgcg gtttggagtc tggcctgggt tccagtcctg gctctgctgc     1620

ttcccactgt gactttgggc aaatcatttc actcctcaaa gcccccccac acaagctgga     1680

ttcccacttc ttacctcatg gagcctgttg aggaaggatt gagctgatga cttaagggca     1740

atctaccaag agacttattc tgtatttggg ggctagaacc atcttccata tttccaagat     1800

tttccaagat gaagccagtg ctagctgaga agcagcaatg aacagaaagc tgtaacactt     1860

atgacaacaa ttcttgcagt gccagaggcc catttacaaa ttctcatttc catctcaaca     1920

gatatagtga catagctcag gctattcatt cataaacaca gagtgtagag tgaaaacact     1980

agagtgaaaa cacatgctac aatgaggcag catcagctga gagcaggaag agcgatctac     2040

tttacacccc acaccaaagg aaaccagatg tgagctgcta aattgactgg ccttgcagag     2100

ctcaagaagg gggcttccaa tgctgtgaga attccgagct gttccctggg ctctgttaac     2160

aggcagagag gttccgggat ggtctgctca agtggcccac actggtcatt gccttaagcc     2220

acctccccag gacttacgga gagaaataag gggatgtaac cagcaatggc cagggtacaa     2280

cagccctgga aaacagtagt aggagcacta ggctttctgg gagtccatcc agctggagtg     2340

gctttgagtg agttacacag ctagaaggtg ccaggttggt gctgccagag attcagaggt     2400

gccatacact tgtcaaatct ggatcattcg tagtgccagc acagtcctaa aagggctgga     2460

gtaccacacc aacacaggta ggggtgcagg gcttcaagta caaagatttg catccatgta     2520

tgtatcaaaa gtgggttctc tgggctgtgg ctttgtctag tagtaccaca gtggctaaag     2580

tagaagaaaa ccaaatcaaa tgggatgtgt cttttgggag gatgtacaag acacaaatct     2640

ttcactaggc accgggcaca gggaaaactg cagggaacaa gagttgtagt gttagtgcaa     2700

ctgtctcaac gatgctgtgt ggcttcagac ccaaacaagg ccctgaggaa ggagactctc     2760

atttccccaa gcataactgc aaggagagga ggaattccta ggagccaaag agttttgtgg     2820

ggtgagggta aataaatggc ccaaatgcca actaggtgaa gttgtgacca tctggctggg     2880

aagcccaggt ccacacagtg taggagcaga tgttttgtgg ggtctgaggt ttacgagatt     2940

tggctgcctt aagaatacaa aaacagaaat gcagaatttc tggggctgct cctaggacca     3000

gaacaagtga agggtcctgg tgcttaaact tcattacctt catggtaaat ccaccagagg     3060

gccggttaga tgctggcccc gccgagagaa ctgctgtcac tttcaggcaa agctcaaagg     3120

tcctaggccc acagttcttt tgagctccag tcatggacat taggaagtaa atcctgcaca     3180

gccaacctgg aataccaaag attagatggg agatagatac caatgattta gatggcacag     3240

gaagagcaag ttctggatat aataaatgag ggtactttcc gtcaaagctt ttctatgtct     3300

atatttatca ctgaatagtc ccagtatggt tttaaagcaa gttttatgaa tctcatttgc     3360

ctaacaggaa tctgaaatat aacttgccaa aaacacacag ttggtgtgga atggtcatta     3420

gaacctgggg ctcctcttca cggactccct gctcattaag ggattcagtg gtccagagtc     3480

taagatccta ttaagtgttt gattcaaacc tctacccgag gaagggctgt taccttactc     3540

ctggtcctgg tttcaagctc attcctgaaa ttccagctgg tttctctagc acctagtgtt     3600

gtttacaaga aggccacggt gctcttagca ttcaaactgc agatactaaa cagatgctgt     3660

gatttattaa agagttagcc atatttcaac aagaaaggga aatgatggct atattcatta     3720

cttacctcaa agcatgctgc aagaaaatta gttagttact tgtcatgctt tgaaatctct     3780

ggatgaaagg tgctttggaa gcacaaacca ttatcacttg tctcataggg attgtcccct     3840

tgaacatcca gcagtgttat tttacagaag acaaattaac tgaaggcttt tcttttatta     3900

catctaaaga gctctacata aacaggtaac attcaatagg taaacaattt ttttccaatg     3960

catgtaataa atattttcac ttggtacttt tatacaaact gacattgtct actatacatt     4020

tttaaaagcc attttactgg tttggcatgc ggtatggaaa ttctaagaga gaaagtttta     4080

aggcaatgaa tcacagattt aagttcatgg aatttatggt aactttatct gtttatgtac     4140

attttcccct ttgttaaaca attaacagca gcacactctg ggaccaccag ctattttccc     4200

tctctttctg aaatctaagc tttgtattta attaaaaaac agaattcaac atctattgat     4260

aaaacaaaat tcttactaaa ataatttcaa atgtgcttta aaaagtcctg aagatcttga     4320

aagttttatg tgtttaaaat tgaaattgtc taaaaaaatg ctctttccac attaatttag     4380

ttaggatata ttttcactcc atttcagaca cttgactcaa aggaaaatct gccaaagaat     4440

ccgatttttc agagcttacg tgaatctttc ctcagtaaag atacagaatt gtgatcatgt     4500

ctaaataatt agtaaagcaa ttttaatgct caaaatagtc aaccaagtat ggcatggttc     4560

tggttcagat tttttttttt taagatgtat ccaataacac tcacgaagta attaaaagcc     4620

actttaaccc tgctaaaaaa aaaaaaaaaa aaaaa                                4655


<210>  120
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ala Ala Glu His Leu Leu Pro Gly Pro Pro Pro Ser Leu Ala Asp 
1               5                   10                  15      


Phe Arg Leu Glu Ala Gly Gly Lys Gly Thr Glu Arg Gly Ser Gly Ser 
            20                  25                  30          


Ser Lys Pro Thr Gly Ser Ser Arg Gly Pro Arg Met Ala Lys Phe Leu 
        35                  40                  45              


Ser Gln Asp Gln Ile Asn Glu Tyr Lys Glu Cys Phe Ser Leu Tyr Asp 
    50                  55                  60                  


Lys Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp Leu Met Val Ala Met 
65                  70                  75                  80  


Arg Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu Val Gln Arg His Leu 
                85                  90                  95      


Gln Thr His Gly Ile Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr Phe 
            100                 105                 110         


Leu Thr Ile Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys Glu 
        115                 120                 125             


Ile Leu Leu Ala Met Leu Met Val Asp Lys Glu Lys Lys Gly Tyr Val 
    130                 135                 140                 


Met Ala Ser Asp Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys Leu 
145                 150                 155                 160 


Thr His Lys Glu Val Asp Asp Leu Phe Arg Glu Ala Asp Ile Glu Pro 
                165                 170                 175     


Asn Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys Ile Thr Leu Pro 
            180                 185                 190         


Gly Arg Asp Tyr 
        195     


<210>  121
<211>  1220
<212>  DNA
<213>  Homo sapiens

<400>  121
gggagcgggc gagtaggagg gggcgccggg ctatatatat agcggctcgg cctcgggcgg       60

gcctggcgct cagggaggcg cgcactgctc ctcagagtcc cagctccagc cgcgcgcttt      120

ccgcccggct cgccgctcca tgcagccggg gtagagcccg gcgcccgggg gccccgtcgc      180

ttgcctcccg cacctcctcg gttgcgcact cctgcccgag gtcggccgtg cgctcccgcg      240

ggacgccaca ggcgcagctc tgccccccag cttcccgggc gcactgaccg cctgaccgac      300

gcacggccct cgggccggga tgtcggggcc cgggacggcc gcggtagcgc tgctcccggc      360

ggtcctgctg gccttgctgg cgccctgggc gggccgaggg ggcgccgccg cacccactgc      420

acccaacggc acgctggagg ccgagctgga gcgccgctgg gagagcctgg tggcgctctc      480

gttggcgcgc ctgccggtgg cagcgcagcc caaggaggcg gccgtccaga gcggcgccgg      540

cgactacctg ctgggcatca agcggctgcg gcggctctac tgcaacgtgg gcatcggctt      600

ccacctccag gcgctccccg acggccgcat cggcggcgcg cacgcggaca cccgcgacag      660

cctgctggag ctctcgcccg tggagcgggg cgtggtgagc atcttcggcg tggccagccg      720

gttcttcgtg gccatgagca gcaagggcaa gctctatggc tcgcccttct tcaccgatga      780

gtgcacgttc aaggagattc tccttcccaa caactacaac gcctacgagt cctacaagta      840

ccccggcatg ttcatcgccc tgagcaagaa tgggaagacc aagaagggga accgagtgtc      900

gcccaccatg aaggtcaccc acttcctccc caggctgtga ccctccagag gacccttgcc      960

tcagcctcgg gaagcccctg ggagggcagt gccgagggtc accttggtgc actttcttcg     1020

gatgaagagt ttaatgcaag agtaggtgta agatatttaa attaattatt taaatgtgta     1080

tatattgcca ccaaattatt tatagttctg cgggtgtgtt ttttaatttt ctggggggaa     1140

aaaaagacaa aacaaaaaac caactctgac ttttctggtg caacagtgga gaatcttacc     1200

attggatttc tttaacttgt                                                 1220


<210>  122
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210>  123
<211>  1985
<212>  DNA
<213>  Homo sapiens

<400>  123
actgtggcta agtgtgggga ccagacagga ctcgtggaga catccaggtg ctgaagcctt       60

cagctactgt ctcagttttt tgaagtttag caatggcgtc tttctctgct gagaccaatt      120

caactgacct actctcacag ccatggaatg agcccccagt aattctctcc atggtcattc      180

tcagccttac ttttttactg ggattgccag gcaatgggct ggtgctgtgg gtggctggcc      240

tgaagatgca gcggacagtg aacacaattt ggttcctcca cctcaccttg gcggacctcc      300

tctgctgcct ctccttgccc ttctcgctgg ctcacttggc tctccaggga cagtggccct      360

acggcaggtt cctatgcaag ctcatcccct ccatcattgt cctcaacatg tttgccagtg      420

tcttcctgct tactgccatt agcctggatc gctgtcttgt ggtattcaag ccaatctggt      480

gtcagaatca tcgcaatgta gggatggcct gctctatctg tggatgtatc tgggtggtgg      540

cttttgtgat gtgcattcct gtgttcgtgt accgggaaat cttcactaca gacaaccata      600

atagatgtgg ctacaaattt ggtctctcca gctcattaga ttatccagac ttttatggag      660

atccactaga aaacaggtct cttgaaaaca ttgttcagcc gcctggagaa atgaatgata      720

ggttagatcc ttcctctttc caaacaaatg atcatccttg gacagtcccc actgtcttcc      780

aacctcaaac atttcaaaga ccttctgcag attcactccc taggggttct gctaggttaa      840

caagtcaaaa tctgtattct aatgtattta aacctgctga tgtggtctca cctaaaatcc      900

ccagtgggtt tcctattgaa gatcacgaaa ccagcccact ggataactct gatgcttttc      960

tctctactca tttaaagctg ttccctagcg cttctagcaa ttccttctac gagtctgagc     1020

taccacaagg tttccaggat tattacaatt taggccaatt cacagatgac gatcaagtgc     1080

caacacccct cgtggcaata acgatcacta ggctagtggt gggtttcctg ctgccctctg     1140

ttatcatgat agcctgttac agcttcattg tcttccgaat gcaaaggggc cgcttcgcca     1200

agtctcagag caaaaccttt cgagtggccg tggtggtggt ggctgtcttt cttgtctgct     1260

ggactccata ccacattttt ggagtcctgt cattgcttac tgacccagaa actcccttgg     1320

ggaaaactct gatgtcctgg gatcatgtat gcattgctct agcatctgcc aatagttgct     1380

ttaatccctt cctttatgcc ctcttgggga aagattttag gaagaaagca aggcagtcca     1440

ttcagggaat tctggaggca gccttcagtg aggagctcac acgttccacc cactgtccct     1500

caaacaatgt catttcagaa agaaatagta caactgtgtg aaaatgtgga gcagccaaca     1560

agcaggggct cttaggcaat cacatagtga aagtttataa gaggatgaag tgatatggtg     1620

agcagcggac ttcaaaaact gtcaaagaat caatccagcg gttctcaaac ggtacacaga     1680

ctattgacat cagcatcacc tagaaacttg ttagaaatgc aaattctcaa gccgcatccc     1740

agacttgctg aatcggaatc tctgggggtt gggacccagc aagggcactt aacaaaccct     1800

cgtttctgat taatgctaaa tgtaagaatc attgtaaaca ttagttctat ttctatccca     1860

aactaagcta tgtgaaataa gagaagctac tttgttttta aatgatgttg aatatttgtc     1920

gatatttcca tcattaaatt tttccttagc attgtaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaa                                                                 1985


<210>  124
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 
    210                 215                 220                 


Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 
                325                 330                 335     


Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 
    450                 455                 460                 


Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 
465                 470                 475                 480 


Thr Val 
        


<210>  125
<211>  1984
<212>  DNA
<213>  Homo sapiens

<400>  125
ctgatttaca ggaactcaca ccagcgatca atcttcctta atttgtaact gggcagtgtc       60

ccgggccagc caatagctaa gactgccccc cccgcacccc accctccctg accctggggg      120

actctctact cagtctgcac tggagctgcc tggtgaccag aagtttggag tccgctgacg      180

tcgccgccca gatggcctcc aggctgaccc tgctgaccct cctgctgctg ctgctggctg      240

gggatagagc ctcctcaaat ccaaatgcta ccagctccag ctcccaggat ccagagagtt      300

tgcaagacag aggcgaaggg aaggtcgcaa caacagttat ctccaagatg ctattcgttg      360

aacccatcct ggaggtttcc agcttgccga caaccaactc aacaaccaat tcagccacca      420

aaataacagc taataccact gatgaaccca ccacacaacc caccacagag cccaccaccc      480

aacccaccat ccaacccacc caaccaacta cccagctccc aacagattct cctacccagc      540

ccactactgg gtccttctgc ccaggacctg ttactctctg ctctgacttg gagagtcatt      600

caacagaggc cgtgttgggg gatgctttgg tagatttctc cctgaagctc taccacgcct      660

tctcagcaat gaagaaggtg gagaccaaca tggccttttc cccattcagc atcgccagcc      720

tccttaccca ggtcctgctc ggggctgggg agaacaccaa aacaaacctg gagagcatcc      780

tctcttaccc caaggacttc acctgtgtcc accaggccct gaagggcttc acgaccaaag      840

gtgtcacctc agtctctcag atcttccaca gcccagacct ggccataagg gacacctttg      900

tgaatgcctc tcggaccctg tacagcagca gccccagagt cctaagcaac aacagtgacg      960

ccaacttgga gctcatcaac acctgggtgg ccaagaacac caacaacaag atcagccggc     1020

tgctagacag tctgccctcc gatacccgcc ttgtcctcct caatgctatc tacctgagtg     1080

ccaagtggaa gacaacattt gatcccaaga aaaccagaat ggaacccttt cacttcaaaa     1140

actcagttat aaaagtgccc atgatgaata gcaagaagta ccctgtggcc catttcattg     1200

accaaacttt gaaagccaag gtggggcagc tgcagctctc ccacaatctg agtttggtga     1260

tcctggtacc ccagaacctg aaacatcgtc ttgaagacat ggaacaggct ctcagccctt     1320

ctgttttcaa ggccatcatg gagaaactgg agatgtccaa gttccagccc actctcctaa     1380

cactaccccg catcaaagtg acgaccagcc aggatatgct ctcaatcatg gagaaattgg     1440

aattcttcga tttttcttat gaccttaacc tgtgtgggct gacagaggac ccagatcttc     1500

aggtttctgc gatgcagcac cagacagtgc tggaactgac agagactggg gtggaggcgg     1560

ctgcagcctc cgccatctct gtggcccgca ccctgctggt ctttgaagtg cagcagccct     1620

tcctcttcgt gctctgggac cagcagcaca agttccctgt cttcatgggg cgagtatatg     1680

accccagggc ctgagacctg caggatcagg ttagggcgag cgctacctct ccagcctcag     1740

ctctcagttg cagccctgct gctgcctgcc tggacttggc ccctgccacc tcctgcctca     1800

ggtgtccgct atccaccaaa agggctccct gagggtctgg gcaagggacc tgcttctatt     1860

agcccttctc catggccctg ccatgctctc caaaccactt tttgcagctt tctctagttc     1920

aagttcacca gactctataa ataaaacctg acagaccatg actttcaaaa aaaaaaaaaa     1980

aaaa                                                                  1984


<210>  126
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  127
<211>  1832
<212>  DNA
<213>  Homo sapiens

<400>  127
gctggctggc tccgcaggtc cgctgacgtc gccgcccaga tggcctccag gctgaccctg       60

ctgaccctcc tgctgctgct gctggctggg gatagagcct cctcaaatcc aaatgctacc      120

agctccagct cccaggatcc agagagtttg caagacagag gcgaagggaa ggtcgcaaca      180

acagttatct ccaagatgct attcgttgaa cccatcctgg aggtttccag cttgccgaca      240

accaactcaa caaccaattc agccaccaaa ataacagcta ataccactga tgaacccacc      300

acacaaccca ccacagagcc caccacccaa cccaccatcc aacccaccca accaactacc      360

cagctcccaa cagattctcc tacccagccc actactgggt ccttctgccc aggacctgtt      420

actctctgct ctgacttgga gagtcattca acagaggccg tgttggggga tgctttggta      480

gatttctccc tgaagctcta ccacgccttc tcagcaatga agaaggtgga gaccaacatg      540

gccttttccc cattcagcat cgccagcctc cttacccagg tcctgctcgg ggctggggag      600

aacaccaaaa caaacctgga gagcatcctc tcttacccca aggacttcac ctgtgtccac      660

caggccctga agggcttcac gaccaaaggt gtcacctcag tctctcagat cttccacagc      720

ccagacctgg ccataaggga cacctttgtg aatgcctctc ggaccctgta cagcagcagc      780

cccagagtcc taagcaacaa cagtgacgcc aacttggagc tcatcaacac ctgggtggcc      840

aagaacacca acaacaagat cagccggctg ctagacagtc tgccctccga tacccgcctt      900

gtcctcctca atgctatcta cctgagtgcc aagtggaaga caacatttga tcccaagaaa      960

accagaatgg aaccctttca cttcaaaaac tcagttataa aagtgcccat gatgaatagc     1020

aagaagtacc ctgtggccca tttcattgac caaactttga aagccaaggt ggggcagctg     1080

cagctctccc acaatctgag tttggtgatc ctggtacccc agaacctgaa acatcgtctt     1140

gaagacatgg aacaggctct cagcccttct gttttcaagg ccatcatgga gaaactggag     1200

atgtccaagt tccagcccac tctcctaaca ctaccccgca tcaaagtgac gaccagccag     1260

gatatgctct caatcatgga gaaattggaa ttcttcgatt tttcttatga ccttaacctg     1320

tgtgggctga cagaggaccc agatcttcag gtttctgcga tgcagcacca gacagtgctg     1380

gaactgacag agactggggt ggaggcggct gcagcctccg ccatctctgt ggcccgcacc     1440

ctgctggtct ttgaagtgca gcagcccttc ctcttcgtgc tctgggacca gcagcacaag     1500

ttccctgtct tcatggggcg agtatatgac cccagggcct gagacctgca ggatcaggtt     1560

agggcgagcg ctacctctcc agcctcagct ctcagttgca gccctgctgc tgcctgcctg     1620

gacttggccc ctgccacctc ctgcctcagg tgtccgctat ccaccaaaag ggctccctga     1680

gggtctgggc aagggacctg cttctattag cccttctcca tggccctgcc atgctctcca     1740

aaccactttt tgcagctttc tctagttcaa gttcaccaga ctctataaat aaaacctgac     1800

agaccatgac tttcaaaaaa aaaaaaaaaa aa                                   1832


<210>  128
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  129
<211>  1916
<212>  DNA
<213>  Homo sapiens

<400>  129
agggacctga aacacagaca aaaggaaaaa caggagggac aaggaggcag aactgagaga       60

ggaggggaca gagaggtgtc ctgggcctga ccccgcccac gagcttgaga aatgctcctg      120

ccccgggagg aggctcagca cagaaggagg aaggacagca cagctgacag ccgtactcag      180

gaagcttctg gatcctaggc ttatctccac agaggagaac acacaagcag cagagaccat      240

ggggcccctc tcagcccctc cctgcacaca gcgcatcacc tggaaggggg tcctgctcac      300

agcatcactt ttaaacttct ggaatccgcc cacaactgcc caagtcacga ttgaagccca      360

gccacccaaa gtttctgagg ggaaggatgt tcttctactt gtccacaatt tgccccagaa      420

tcttgctggc tacatttggt acaaagggca aatgacatac ctctaccatt acattacatc      480

atatgtagta gacggtcaaa gaattatata tgggcctgca tacagtggaa gagaaagagt      540

atattccaat gcatccctgc tgatccagaa tgtcacgcag gaggatgcag gatcctacac      600

cttacacatc ataaagcgac gcgatgggac tggaggagta actggacatt tcaccttcac      660

cttacaccca aagctgtcca agccctacat cacaatcaac aacttaaacc ccagagagaa      720

taaggatgtc ttaaccttca cctgtgaacc taagagtaag aactacacct acatttggtg      780

gctaaatggt cagagcctcc ctgtcagtcc cagggtaaag cgacccattg aaaacaggat      840

cctcattcta cccaatgtca cgagaaatga aacaggacct tatcaatgtg aaatacggga      900

ccgatatggt ggcatccgca gtgacccagt caccctgaat gtcctctatg gtccagacct      960

ccccagcatt tacccttcat tcacctatta ccgttcagga gaaaacctct acttgtcctg     1020

cttcgccgag tctaacccac gggcacaata ttcttggaca attaatggga agtttcagct     1080

atcaggacaa aagctctcta tcccccaaat aactacaaag catagtgggc tctatgcttg     1140

ctctgttcgt aactcagcca ctggcaagga aagctccaaa tccatcacag tcaaagtctc     1200

tgactggata ttaccctgaa ttctactagt tcctccaatt ccattttctc ccatggaatc     1260

acgaagagca agacccactc tgttccagaa gccctataag ctggaggtgg acaactcgat     1320

gtaaatttca tgggaaaacc cttgtacctg acatgtgagc cactcagaac tcaccaaaat     1380

gttcgacacc ataacaacag ctactcaaac tgtaaaccag gataacaagt tgatgacttc     1440

acactgtgga cagtttttcc aaagatgtca gaacaagact ccccatcatg ataaggctcc     1500

cacccctctt aaccgtcctt gctcatgcct gcctctttca cttggcagga taatgcagtc     1560

attagaattt cacatgtagt agcttctgag ggtaacaaca gagtgtcaga tatgtcatct     1620

caacctcaaa cttttacgta acatctcagg ggaaatgtgg ctctctccat cttgcataca     1680

gggctcccaa tagaaatgaa cacagagata ttgcctgtgt gtttgcagag aagatggttt     1740

ctataaagag taggaaagct gaaattatag tagagtctcc tttaaatgca cattgtgtgg     1800

atggctctca ccatttccta agagatacag tgtaaaacgt gacagtaata ctgattctag     1860

cagaataaaa catgtaccac atttgctaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         1916


<210>  130
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln Arg Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Thr Tyr Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Arg Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Arg Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Arg 
        115                 120                 125             


Asp Gly Thr Gly Gly Val Thr Gly His Phe Thr Phe Thr Leu His Pro 
    130                 135                 140                 


Lys Leu Ser Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Asn Lys Asp Val Leu Thr Phe Thr Cys Glu Pro Lys Ser Lys Asn Tyr 
                165                 170                 175     


Thr Tyr Ile Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg 
            180                 185                 190         


Val Lys Arg Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Asn Val Thr 
        195                 200                 205             


Arg Asn Glu Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly 
    210                 215                 220                 


Gly Ile Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
225                 230                 235                 240 


Leu Pro Ser Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn 
                245                 250                 255     


Leu Tyr Leu Ser Cys Phe Ala Glu Ser Asn Pro Arg Ala Gln Tyr Ser 
            260                 265                 270         


Trp Thr Ile Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile 
        275                 280                 285             


Pro Gln Ile Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg 
    290                 295                 300                 


Asn Ser Ala Thr Gly Lys Glu Ser Ser Lys Ser Ile Thr Val Lys Val 
305                 310                 315                 320 


Ser Asp Trp Ile Leu Pro 
                325     


<210>  131
<211>  2195
<212>  DNA
<213>  Homo sapiens

<400>  131
agggacctga aacacagaca aaaggaaaaa caggagggac aaggaggcag aactgagaga       60

ggaggggaca gagaggtgtc ctgggcctga ccccgcccac gagcttgaga aatgctcctg      120

ccccgggagg aggctcagca cagaaggagg aaggacagca cagctgacag ccgtactcag      180

gaagcttctg gatcctaggc ttatctccac agaggagaac acacaagcag cagagaccat      240

ggggcccctc tcagcccctc cctgcacaca gcgcatcacc tggaaggggg tcctgctcac      300

agcatcactt ttaaacttct ggaatccgcc cacaactgcc caagtcacga ttgaagccca      360

gccacccaaa gtttctgagg ggaaggatgt tcttctactt gtccacaatt tgccccagaa      420

tcttgctggc tacatttggt acaaagggca aatgacatac ctctaccatt acattacatc      480

atatgtagta gacggtcaaa gaattatata tgggcctgca tacagtggaa gagaaagagt      540

atattccaat gcatccctgc tgatccagaa tgtcacgcag gaggatgcag gatcctacac      600

cttacacatc ataaagcgac gcgatgggac tggaggagta actggacatt tcaccttcac      660

cttacacctg gagactccca agccctccat ctccagcagc aacttaaatc ccagggaggc      720

catggaggct gtgatcttaa cctgtgatcc tgcgactcca gccgcaagct accagtggtg      780

gatgaatggt cagagcctcc ctatgactca caggttgcag ctgtccaaaa ccaacaggac      840

cctctttata tttggtgtca caaagtatat tgcaggaccc tatgaatgtg aaatacggaa      900

cccagtgagt gccagccgca gtgacccagt caccctgaat ctcctcccaa agctgtccaa      960

gccctacatc acaatcaaca acttaaaccc cagagagaat aaggatgtct taaccttcac     1020

ctgtgaacct aagagtaaga actacaccta catttggtgg ctaaatggtc agagcctccc     1080

tgtcagtccc agggtaaagc gacccattga aaacaggatc ctcattctac ccaatgtcac     1140

gagaaatgaa acaggacctt atcaatgtga aatacgggac cgatatggtg gcatccgcag     1200

tgacccagtc accctgaatg tcctctatgg tccagacctc cccagcattt acccttcatt     1260

cacctattac cgttcaggag aaaacctcta cttgtcctgc ttcgccgagt ctaacccacg     1320

ggcacaatat tcttggacaa ttaatgggaa gtttcagcta tcaggacaaa agctctctat     1380

cccccaaata actacaaagc atagtgggct ctatgcttgc tctgttcgta actcagccac     1440

tggcaaggaa agctccaaat ccatcacagt caaagtctct gactggatat taccctgaat     1500

tctactagtt cctccaattc cattttctcc catggaatca cgaagagcaa gacccactct     1560

gttccagaag ccctataagc tggaggtgga caactcgatg taaatttcat gggaaaaccc     1620

ttgtacctga catgtgagcc actcagaact caccaaaatg ttcgacacca taacaacagc     1680

tactcaaact gtaaaccagg ataacaagtt gatgacttca cactgtggac agtttttcca     1740

aagatgtcag aacaagactc cccatcatga taaggctccc acccctctta accgtccttg     1800

ctcatgcctg cctctttcac ttggcaggat aatgcagtca ttagaatttc acatgtagta     1860

gcttctgagg gtaacaacag agtgtcagat atgtcatctc aacctcaaac ttttacgtaa     1920

catctcaggg gaaatgtggc tctctccatc ttgcatacag ggctcccaat agaaatgaac     1980

acagagatat tgcctgtgtg tttgcagaga agatggtttc tataaagagt aggaaagctg     2040

aaattatagt agagtctcct ttaaatgcac attgtgtgga tggctctcac catttcctaa     2100

gagatacagt gtaaaacgtg acagtaatac tgattctagc agaataaaac atgtaccaca     2160

tttgctaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                2195


<210>  132
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln Arg Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Thr Tyr Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Arg Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Arg Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Arg 
        115                 120                 125             


Asp Gly Thr Gly Gly Val Thr Gly His Phe Thr Phe Thr Leu His Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Ala Met Glu Ala Val Ile Leu Thr Cys Asp Pro Ala Thr Pro Ala Ala 
                165                 170                 175     


Ser Tyr Gln Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Arg 
            180                 185                 190         


Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Phe Ile Phe Gly Val Thr 
        195                 200                 205             


Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Ser 
225                 230                 235                 240 


Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Thr Phe Thr Cys Glu Pro Lys Ser Lys Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Asn Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg 
305                 310                 315                 320 


Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Ser 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Tyr Leu 
            340                 345                 350         


Ser Cys Phe Ala Glu Ser Asn Pro Arg Ala Gln Tyr Ser Trp Thr Ile 
        355                 360                 365             


Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile 
    370                 375                 380                 


Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ser Ser Lys Ser Ile Thr Val Lys Val Ser Asp Trp 
                405                 410                 415     


Ile Leu Pro 
            


<210>  133
<211>  1916
<212>  DNA
<213>  Homo sapiens

<400>  133
agggacctga aacacagaca aaaggaaaaa caggagggac aaggaggcag aactgagaga       60

ggaggggaca gagaggtgtc ctgggcctga ccccgcccac gagcttgaga aatgctcctg      120

ccccgggagg aggctcagca cagaaggagg aaggacagca cagctgacag ccgtactcag      180

gaagcttctg gatcctaggc ttatctccac agaggagaac acacaagcag cagagaccat      240

ggggcccctc tcagcccctc cctgcacaca gcgcatcacc tggaaggggg tcctgctcac      300

agcatcactt ttaaacttct ggaatccgcc cacaactgcc caagtcacga ttgaagccca      360

gccacccaaa gtttctgagg ggaaggatgt tcttctactt gtccacaatt tgccccagaa      420

tcttgctggc tacatttggt acaaagggca aatgacatac ctctaccatt acattacatc      480

atatgtagta gacggtcaaa gaattatata tgggcctgca tacagtggaa gagaaagagt      540

atattccaat gcatccctgc tgatccagaa tgtcacgcag gaggatgcag gatcctacac      600

cttacacatc ataaagcgac gcgatgggac tggaggagta actggacatt tcaccttcac      660

cttacacctg gagactccca agccctccat ctccagcagc aacttaaatc ccagggaggc      720

catggaggct gtgatcttaa cctgtgatcc tgcgactcca gccgcaagct accagtggtg      780

gatgaatggt cagagcctcc ctatgactca caggttgcag ctgtccaaaa ccaacaggac      840

cctctttata tttggtgtca caaagtatat tgcaggaccc tatgaatgtg aaatacggaa      900

cccagtgagt gccagccgca gtgacccagt caccctgaat ctcctccatg gtccagacct      960

ccccagcatt tacccttcat tcacctatta ccgttcagga gaaaacctct acttgtcctg     1020

cttcgccgag tctaacccac gggcacaata ttcttggaca attaatggga agtttcagct     1080

atcaggacaa aagctctcta tcccccaaat aactacaaag catagtgggc tctatgcttg     1140

ctctgttcgt aactcagcca ctggcaagga aagctccaaa tccatcacag tcaaagtctc     1200

tgactggata ttaccctgaa ttctactagt tcctccaatt ccattttctc ccatggaatc     1260

acgaagagca agacccactc tgttccagaa gccctataag ctggaggtgg acaactcgat     1320

gtaaatttca tgggaaaacc cttgtacctg acatgtgagc cactcagaac tcaccaaaat     1380

gttcgacacc ataacaacag ctactcaaac tgtaaaccag gataacaagt tgatgacttc     1440

acactgtgga cagtttttcc aaagatgtca gaacaagact ccccatcatg ataaggctcc     1500

cacccctctt aaccgtcctt gctcatgcct gcctctttca cttggcagga taatgcagtc     1560

attagaattt cacatgtagt agcttctgag ggtaacaaca gagtgtcaga tatgtcatct     1620

caacctcaaa cttttacgta acatctcagg ggaaatgtgg ctctctccat cttgcataca     1680

gggctcccaa tagaaatgaa cacagagata ttgcctgtgt gtttgcagag aagatggttt     1740

ctataaagag taggaaagct gaaattatag tagagtctcc tttaaatgca cattgtgtgg     1800

atggctctca ccatttccta agagatacag tgtaaaacgt gacagtaata ctgattctag     1860

cagaataaaa catgtaccac atttgctaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         1916


<210>  134
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln Arg Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Thr Tyr Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Arg Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Arg Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Arg 
        115                 120                 125             


Asp Gly Thr Gly Gly Val Thr Gly His Phe Thr Phe Thr Leu His Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Ala Met Glu Ala Val Ile Leu Thr Cys Asp Pro Ala Thr Pro Ala Ala 
                165                 170                 175     


Ser Tyr Gln Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Arg 
            180                 185                 190         


Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Phe Ile Phe Gly Val Thr 
        195                 200                 205             


Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu His Gly Pro Asp 
225                 230                 235                 240 


Leu Pro Ser Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn 
                245                 250                 255     


Leu Tyr Leu Ser Cys Phe Ala Glu Ser Asn Pro Arg Ala Gln Tyr Ser 
            260                 265                 270         


Trp Thr Ile Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile 
        275                 280                 285             


Pro Gln Ile Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg 
    290                 295                 300                 


Asn Ser Ala Thr Gly Lys Glu Ser Ser Lys Ser Ile Thr Val Lys Val 
305                 310                 315                 320 


Ser Asp Trp Ile Leu Pro 
                325     


<210>  135
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  135
acttccgggt tgggccgtgg gctggggagt cgtggaggcg cggtcctggt ccccacccgg       60

cgcgctggga ctcgcccgcc tcccgtctgt caccccctgc gcctcgccgg gacaacgggg      120

tgagggcatg ggggcgtggg gccccagcct atgttccccg cggcactggc gcggcggccg      180

cgccgaccga agtccgggac gggggagggg cccgagcgcc agcggccggg cgggagtctc      240

aggagcgggt tcccggtccc tgcaggcggc ctggcgggtg gcatcgagat ctgcatcacc      300

ttccccaccg agtacgtgaa gacgcagctg cagctggacg agcgctcgca cccgccgcgg      360

taccggggca tcggggactg cgtgcggcag acggttcgca gccatggcgt cctgggcctg      420

taccgcggcc ttagctccct gctctacggt tccatcccca aggcggccgt caggtttgga      480

atgttcgagt tcctcagcaa ccacatgcgg gatgcccagg gacggctgga cagcacgcgt      540

gggctgctgt gcggcctggg cgctggcgtg gccgaggccg tggtggtcgt gtgccccatg      600

gagaccatca aggtgaagtt catccacgac cagacctccc caaaccccaa gtacagagga      660

ttcttccacg gggttaggga gattgtgcgg gaacaagggc tgaaggggac gtaccagggc      720

ctcacagcca ctgtcctgaa gcagggctcg aaccaggcca tccgcttctt cgtcatgacc      780

tccctgcgca actggtaccg aggggacaac cccaacaagc ccatgaaccc tctgatcact      840

ggggtcttcg gagctattgc aggcgcagcc agtgtctttg gaaacactcc tctggatgtg      900

attaagaccc ggatgcaggg cctggaggcg cacaaatacc ggaacacgtg ggactgcggc      960

ttgcagatcc tgaagaagga ggggctcaag gcattctaca agggcactgt cccccgcctg     1020

ggccgggtct gcctggatgt ggccatagtg tttgtcatct atgatgaagt ggtgaagctg     1080

ctcaacaaag tgtggaagac ggactaagcc tagagaggcc gcaaggggac cgccccaggc     1140

accgccagag tgtcctgcta cctttgtctc acgattccag tgcagtagtg ccaaaaggcc     1200

ccttcccacg tccctcgagc tctgtagcct ggtctgtgca ttgtggctgt caaatccatg     1260

tgtcccccct gtggtctgtg tgtgacacca ccactgtgtc ccagtgtctg gcccagccat     1320

ggctggatgt gcatctggcc tatgaccctg tgcctgtgtt tcatgttctg tgtcacgtga     1380

ccctgtgccc cgcctcccgg ggtgcccgtg tggcctgggt cctcggccct gtagccctgg     1440

cccggtccca gtccggtgcc ttccaccctg ccctggccta ccacagctgc ctccgggcct     1500

cggcctggct tcaccgcatt ccaggggctg cagccccctg cttctcccgc cattggcctt     1560

aactggccct cgggccctct ctccgccccg gacagggtgg cacccaccac tctcaggacc     1620

accctgccaa ggcagaataa accggatcct gttgcagcct ccaaaaaaaa aaaaaaaaaa     1680


<210>  136
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Phe Pro Ala Ala Leu Ala Arg Arg Pro Arg Arg Pro Lys Ser Gly 
1               5                   10                  15      


Thr Gly Glu Gly Pro Glu Arg Gln Arg Pro Gly Gly Ser Leu Arg Ser 
            20                  25                  30          


Gly Phe Pro Val Pro Ala Gly Gly Leu Ala Gly Gly Ile Glu Ile Cys 
        35                  40                  45              


Ile Thr Phe Pro Thr Glu Tyr Val Lys Thr Gln Leu Gln Leu Asp Glu 
    50                  55                  60                  


Arg Ser His Pro Pro Arg Tyr Arg Gly Ile Gly Asp Cys Val Arg Gln 
65                  70                  75                  80  


Thr Val Arg Ser His Gly Val Leu Gly Leu Tyr Arg Gly Leu Ser Ser 
                85                  90                  95      


Leu Leu Tyr Gly Ser Ile Pro Lys Ala Ala Val Arg Phe Gly Met Phe 
            100                 105                 110         


Glu Phe Leu Ser Asn His Met Arg Asp Ala Gln Gly Arg Leu Asp Ser 
        115                 120                 125             


Thr Arg Gly Leu Leu Cys Gly Leu Gly Ala Gly Val Ala Glu Ala Val 
    130                 135                 140                 


Val Val Val Cys Pro Met Glu Thr Ile Lys Val Lys Phe Ile His Asp 
145                 150                 155                 160 


Gln Thr Ser Pro Asn Pro Lys Tyr Arg Gly Phe Phe His Gly Val Arg 
                165                 170                 175     


Glu Ile Val Arg Glu Gln Gly Leu Lys Gly Thr Tyr Gln Gly Leu Thr 
            180                 185                 190         


Ala Thr Val Leu Lys Gln Gly Ser Asn Gln Ala Ile Arg Phe Phe Val 
        195                 200                 205             


Met Thr Ser Leu Arg Asn Trp Tyr Arg Gly Asp Asn Pro Asn Lys Pro 
    210                 215                 220                 


Met Asn Pro Leu Ile Thr Gly Val Phe Gly Ala Ile Ala Gly Ala Ala 
225                 230                 235                 240 


Ser Val Phe Gly Asn Thr Pro Leu Asp Val Ile Lys Thr Arg Met Gln 
                245                 250                 255     


Gly Leu Glu Ala His Lys Tyr Arg Asn Thr Trp Asp Cys Gly Leu Gln 
            260                 265                 270         


Ile Leu Lys Lys Glu Gly Leu Lys Ala Phe Tyr Lys Gly Thr Val Pro 
        275                 280                 285             


Arg Leu Gly Arg Val Cys Leu Asp Val Ala Ile Val Phe Val Ile Tyr 
    290                 295                 300                 


Asp Glu Val Val Lys Leu Leu Asn Lys Val Trp Lys Thr Asp 
305                 310                 315             


<210>  137
<211>  1516
<212>  DNA
<213>  Homo sapiens

<400>  137
acttccgggt tgggccgtgg gctggggagt cgtggaggcg cggtcctggt ccccacccgg       60

cgcgctggga ctcgcccgcc tcccgtctgt caccccctgc gcctcgccgg gacaacgggg      120

cggcctggcg ggtggcatcg agatctgcat caccttcccc accgagtacg tgaagacgca      180

gctgcagctg gacgagcgct cgcacccgcc gcggtaccgg ggcatcgggg actgcgtgcg      240

gcagacggtt cgcagccatg gcgtcctggg cctgtaccgc ggccttagct ccctgctcta      300

cggttccatc cccaaggcgg ccgtcaggtt tggaatgttc gagttcctca gcaaccacat      360

gcgggatgcc cagggacggc tggacagcac gcgtgggctg ctgtgcggcc tgggcgctgg      420

cgtggccgag gccgtggtgg tcgtgtgccc catggagacc atcaaggtga agttcatcca      480

cgaccagacc tccccaaacc ccaagtacag aggattcttc cacggggtta gggagattgt      540

gcgggaacaa gggctgaagg ggacgtacca gggcctcaca gccactgtcc tgaagcaggg      600

ctcgaaccag gccatccgct tcttcgtcat gacctccctg cgcaactggt accgagggga      660

caaccccaac aagcccatga accctctgat cactggggtc ttcggagcta ttgcaggcgc      720

agccagtgtc tttggaaaca ctcctctgga tgtgattaag acccggatgc agggcctgga      780

ggcgcacaaa taccggaaca cgtgggactg cggcttgcag atcctgaaga aggaggggct      840

caaggcattc tacaagggca ctgtcccccg cctgggccgg gtctgcctgg atgtggccat      900

agtgtttgtc atctatgatg aagtggtgaa gctgctcaac aaagtgtgga agacggacta      960

agcctagaga ggccgcaagg ggaccgcccc aggcaccgcc agagtgtcct gctacctttg     1020

tctcacgatt ccagtgcagt agtgccaaaa ggccccttcc cacgtccctc gagctctgta     1080

gcctggtctg tgcattgtgg ctgtcaaatc catgtgtccc ccctgtggtc tgtgtgtgac     1140

accaccactg tgtcccagtg tctggcccag ccatggctgg atgtgcatct ggcctatgac     1200

cctgtgcctg tgtttcatgt tctgtgtcac gtgaccctgt gccccgcctc ccggggtgcc     1260

cgtgtggcct gggtcctcgg ccctgtagcc ctggcccggt cccagtccgg tgccttccac     1320

cctgccctgg cctaccacag ctgcctccgg gcctcggcct ggcttcaccg cattccaggg     1380

gctgcagccc cctgcttctc ccgccattgg ccttaactgg ccctcgggcc ctctctccgc     1440

cccggacagg gtggcaccca ccactctcag gaccaccctg ccaaggcaga ataaaccgga     1500

tcctgttgca gcctcc                                                     1516


<210>  138
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Phe Glu Phe Leu Ser Asn His Met Arg Asp Ala Gln Gly Arg Leu 
1               5                   10                  15      


Asp Ser Thr Arg Gly Leu Leu Cys Gly Leu Gly Ala Gly Val Ala Glu 
            20                  25                  30          


Ala Val Val Val Val Cys Pro Met Glu Thr Ile Lys Val Lys Phe Ile 
        35                  40                  45              


His Asp Gln Thr Ser Pro Asn Pro Lys Tyr Arg Gly Phe Phe His Gly 
    50                  55                  60                  


Val Arg Glu Ile Val Arg Glu Gln Gly Leu Lys Gly Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Thr Ala Thr Val Leu Lys Gln Gly Ser Asn Gln Ala Ile Arg Phe 
                85                  90                  95      


Phe Val Met Thr Ser Leu Arg Asn Trp Tyr Arg Gly Asp Asn Pro Asn 
            100                 105                 110         


Lys Pro Met Asn Pro Leu Ile Thr Gly Val Phe Gly Ala Ile Ala Gly 
        115                 120                 125             


Ala Ala Ser Val Phe Gly Asn Thr Pro Leu Asp Val Ile Lys Thr Arg 
    130                 135                 140                 


Met Gln Gly Leu Glu Ala His Lys Tyr Arg Asn Thr Trp Asp Cys Gly 
145                 150                 155                 160 


Leu Gln Ile Leu Lys Lys Glu Gly Leu Lys Ala Phe Tyr Lys Gly Thr 
                165                 170                 175     


Val Pro Arg Leu Gly Arg Val Cys Leu Asp Val Ala Ile Val Phe Val 
            180                 185                 190         


Ile Tyr Asp Glu Val Val Lys Leu Leu Asn Lys Val Trp Lys Thr Asp 
        195                 200                 205             


<210>  139
<211>  1699
<212>  DNA
<213>  Homo sapiens

<400>  139
agtttcccgg cccgcacggg gcgggctggg ggcggggcct ggctcggacc acgcggggcg       60

ggacctggag ctgacgcggc cgccccgccc ctgggaccat aaccggccgc cgccgccacc      120

gcggaccgag cgcggagttc tggagtctcg gacccgaagc cgccacaggg cgccccgcct      180

cccgcccgcc atgcccgcgc cccgcgcccc gcgcgctctg gcggccgccg cgcccgcgtc      240

cgggaaggcc aagctgacgc acccggggaa ggcgatcctg gcaggcggcc tggcgggtgg      300

catcgagatc tgcatcacct tccccaccga gtacgtgaag acgcagctgc agctggacga      360

gcgctcgcac ccgccgcggt accggggcat cggggactgc gtgcggcaga cggttcgcag      420

ccatggcgtc ctgggcctgt accgcggcct tagctccctg ctctacggtt ccatccccaa      480

ggcggccgtc aggtttggaa tgttcgagtt cctcagcaac cacatgcggg atgcccaggg      540

acggctggac agcacgcgtg ggctgctgtg cggcctgggc gctggcgtgg ccgaggccgt      600

ggtggtcgtg tgccccatgg agaccatcaa ggtgaagttc atccacgacc agacctcccc      660

aaaccccaag tacagaggat tcttccacgg ggttagggag attgtgcggg aacaagggct      720

gaaggggacg taccagggcc tcacagccac tgtcctgaag cagggctcga accaggccat      780

ccgcttcttc gtcatgacct ccctgcgcaa ctggtaccga ggggacaacc ccaacaagcc      840

catgaaccct ctgatcactg gggtcttcgg agctattgca ggcgcagcca gtgtctttgg      900

aaacactcct ctggatgtga ttaagacccg gatgcagggc ctggaggcgc acaaataccg      960

gaacacgtgg gactgcggct tgcagatcct gaagaaggag gggctcaagg cattctacaa     1020

gggcactgtc ccccgcctgg gccgggtctg cctggatgtg gccatagtgt ttgtcatcta     1080

tgatgaagtg gtgaagctgc tcaacaaagt gtggaagacg gactaagcct agagaggccg     1140

caaggggacc gccccaggca ccgccagagt gtcctgctac ctttgtctca cgattccagt     1200

gcagtagtgc caaaaggccc cttcccacgt ccctcgagct ctgtagcctg gtctgtgcat     1260

tgtggctgtc aaatccatgt gtcccccctg tggtctgtgt gtgacaccac cactgtgtcc     1320

cagtgtctgg cccagccatg gctggatgtg catctggcct atgaccctgt gcctgtgttt     1380

catgttctgt gtcacgtgac cctgtgcccc gcctcccggg gtgcccgtgt ggcctgggtc     1440

ctcggccctg tagccctggc ccggtcccag tccggtgcct tccaccctgc cctggcctac     1500

cacagctgcc tccgggcctc ggcctggctt caccgcattc caggggctgc agccccctgc     1560

ttctcccgcc attggcctta actggccctc gggccctctc tccgccccgg acagggtggc     1620

acccaccact ctcaggacca ccctgccaag gcagaataaa ccggatcctg ttgcagcctc     1680

caaaaaaaaa aaaaaaaaa                                                  1699


<210>  140
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Pro Ala Pro Arg Ala Pro Arg Ala Leu Ala Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ser Gly Lys Ala Lys Leu Thr His Pro Gly Lys Ala Ile Leu Ala Gly 
            20                  25                  30          


Gly Leu Ala Gly Gly Ile Glu Ile Cys Ile Thr Phe Pro Thr Glu Tyr 
        35                  40                  45              


Val Lys Thr Gln Leu Gln Leu Asp Glu Arg Ser His Pro Pro Arg Tyr 
    50                  55                  60                  


Arg Gly Ile Gly Asp Cys Val Arg Gln Thr Val Arg Ser His Gly Val 
65                  70                  75                  80  


Leu Gly Leu Tyr Arg Gly Leu Ser Ser Leu Leu Tyr Gly Ser Ile Pro 
                85                  90                  95      


Lys Ala Ala Val Arg Phe Gly Met Phe Glu Phe Leu Ser Asn His Met 
            100                 105                 110         


Arg Asp Ala Gln Gly Arg Leu Asp Ser Thr Arg Gly Leu Leu Cys Gly 
        115                 120                 125             


Leu Gly Ala Gly Val Ala Glu Ala Val Val Val Val Cys Pro Met Glu 
    130                 135                 140                 


Thr Ile Lys Val Lys Phe Ile His Asp Gln Thr Ser Pro Asn Pro Lys 
145                 150                 155                 160 


Tyr Arg Gly Phe Phe His Gly Val Arg Glu Ile Val Arg Glu Gln Gly 
                165                 170                 175     


Leu Lys Gly Thr Tyr Gln Gly Leu Thr Ala Thr Val Leu Lys Gln Gly 
            180                 185                 190         


Ser Asn Gln Ala Ile Arg Phe Phe Val Met Thr Ser Leu Arg Asn Trp 
        195                 200                 205             


Tyr Arg Gly Asp Asn Pro Asn Lys Pro Met Asn Pro Leu Ile Thr Gly 
    210                 215                 220                 


Val Phe Gly Ala Ile Ala Gly Ala Ala Ser Val Phe Gly Asn Thr Pro 
225                 230                 235                 240 


Leu Asp Val Ile Lys Thr Arg Met Gln Gly Leu Glu Ala His Lys Tyr 
                245                 250                 255     


Arg Asn Thr Trp Asp Cys Gly Leu Gln Ile Leu Lys Lys Glu Gly Leu 
            260                 265                 270         


Lys Ala Phe Tyr Lys Gly Thr Val Pro Arg Leu Gly Arg Val Cys Leu 
        275                 280                 285             


Asp Val Ala Ile Val Phe Val Ile Tyr Asp Glu Val Val Lys Leu Leu 
    290                 295                 300                 


Asn Lys Val Trp Lys Thr Asp 
305                 310     


